Digital Commons Network^™

Examining The Relationship Between Anxiety Severity And Autism-Related Challenges During Cognitive Behavioral Therapy For Children With Autism, Madeleine N Fuselier, Andrew G Guzick, Jafar Bakhshaie, Jeffrey J Wood, Philip C Kendall, Connor M Kerns, Brent J Small, Wayne K Goodman, Eric A Storch

Faculty, Staff and Students Publications

PURPOSE: Using data from a randomized clinical trial evaluating cognitive behavioral therapy (CBT) for children with autism and co-occurring anxiety, this study examined the relationship between autism features and anxiety symptoms throughout CBT.

METHODS: Two multilevel mediation analyses were run which examined the mediating role of changes in anxiety for changes in two core features of autism, (a) repetitive and restrictive behaviors (RRBs) and (b) social communication/interaction impairments, between pre- and post-treatment.

RESULTS: Indirect effects between time and autism characteristics were significant for both models, indicating that as anxiety changes, so do RRBs and social communication/interaction as the outcomes respectively. …

Rejection, Creation, And Abolitionist Futures: Sustaining Ecosystems Of Care Under Neoliberal Violence 1980-Present, Maya Phelps

Senior Honors Papers / Undergraduate Theses

The enforcement of the child welfare system through policies, funding practices, and ideologies is a national investment in the nuclear family as a critical social institution to the United States (US); this investment communicates to the broader population that conforming to this heteropatriarchal, white supremacist conception of family provides protection from state intervention to those who conform. My project interrogates child welfare’s enforcement of normative families, and the resistance from Black family formations and kinship based on their social position and its relation to power. Focusing on the period between 1980 and the present, I examine the ways Black family …

A Case Of Helix-Fixation Leadless Pacemaker Dislodgment And Retrieval: The Importance Of Achieving Appropriate Postimplant Impedance, Faris Haddadin, Gilad Birnbaum, Laith Alhuneafat, Ahmad Jabri, Owais Ulhaq, Irakli Giorgberidze, Hamid Afshar

Faculty, Staff and Students Publications

No abstract provided.

The Impact Of One Night Of Sleep Restriction On Perception Of Subsequent Aerobic Exercise Performance, Erin G. Meier

Senior Honors Projects, 2020-current

Introduction: Previous research has established that poor sleep quality negatively impacts aerobic exercise performance. A majority of that research has examined extreme sleep disruption like complete sleep deprivation or multiple nights of reduced sleep. Little research exists examining the effect of a singular night of sleep restriction (SR) on performance, and there is even less research on the associated perceptual feelings and outcomes from SR that may influence performance. Previous research from our laboratory has suggested that a single night of SR may impair performance, but did not account for sleep inertia or examine any perceptual factors. Therefore, the …

Improved Test Fixture For Collecting Microcontact Performance And Reliability Data, Turja Nandy, Ronald A. Coutu Jr., Rafee Mahbub

Electrical and Computer Engineering Faculty Research and Publications

Microelectromechanical systems (MEMS) ohmic contact switches are considered to be a promising candidate for wireless communication applications. The longevity of MEMS switches is directly related to the reliability and performance of microcontacts. In this work, an improved microcontact test fixture with high actuation rates (KHz) and highly precise position control (nm) and force (nN) control was developed. Here, we collected microcontact performance data from initial contact tests (ICT) and microcontact reliability data from cold switched tests (CST). To perform these tests with our test fixture, we fabricated MEMS microcontact test structures with relatively high Young’s modulus electroplated Nickel (Ni)-based, fixed–fixed …

Texture-Based Classification To Overcome Uncertainty Between Covid-19 And Viral Pneumonia Using Machine Learning And Deep Learning Techniques, Omar Farghaly, Priya Deshpande

Electrical and Computer Engineering Faculty Research and Publications

The SARS-CoV-2 virus, responsible for COVID-19, often manifests symptoms akin to viral pneumonia, complicating early detection and potentially leading to severe COVID pneumonia and long-term effects. Particularly affecting young individuals, the elderly, and those with weakened immune systems, the accurate classification of COVID-19 poses challenges, especially with highly dimensional image data. Past studies have faced limitations due to simplistic algorithms and small, biased datasets, yielding inaccurate results. In response, our study introduces a novel classification model that integrates advanced texture feature extraction methods, including GLCM, GLDM, and wavelet transform, within a deep learning framework. This innovative approach enables the effective …

Piezo1 Regulates Meningeal Lymphatic Vessel Drainage And Alleviates Excessive Csf Accumulation, Dongwon Choi, Eunkyung Park, Joshua Choi, Renhao Lu, Jin Suh Yu, Chiyoon Kim, Luping Zhao, James Yu, Brandon Nakashima, Sunju Lee, Dhruv Singhal, Joshua P Scallan, Bin Zhou, Chester J Koh, Esak Lee, Young-Kwon Hong

Faculty, Staff and Students Publications

Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into biological processes. Here, we find that Piezo1 is necessary for the proper development and function of meningeal lymphatic vessels and that activating Piezo1 through transgenic overexpression or treatment with the chemical agonist Yoda1 is sufficient to increase cerebrospinal fluid (CSF) outflow by improving lymphatic absorption and transport. The abnormal accumulation of CSF, which often leads to hydrocephalus and ventriculomegaly, currently lacks effective treatments. We discovered that meningeal lymphatics in mouse models of Down syndrome were incompletely developed and abnormally formed. Selective overexpression of …

Effects Of Serum Potassium On Mortality In Patients With St-Elevation Myocardial Infarction, Colton J Jensen, Jonathan K Nielsen, Matthew M Talbott, Danielle O'Connell, Vivek S Patel, Peyton A Armstrong, Zubaid Rafique, Lillian M Tia, Krishna K Paul, Dietrich V Jehle

Faculty, Staff and Students Publications

Introduction: Disturbances in potassium levels can induce ventricular arrhythmias and heighten mortality in patients with ST-elevation myocardial infarction (STEMI). This study evaluates the influence of sK levels on seven-day mortality and incidence of ventricular arrhythmias in STEMI patients to further improve clinical guidelines and outcomes.

Methods: This retrospective, propensity-matched study analyzed approximately 250,000 acute STEMI patients from 55 major academic medical centers/healthcare organizations (HCOs) in the US Collaborative Network of the TriNetX database. The sK levels recorded on the day of STEMI diagnosis were categorized into four cohorts: sK ≤ 3.4 (hypokalemia), 3.5 ≤ sK ≤ 4.5 (normal-control), 4.6 ≤ …

Immunotherapy Withdrawal By Step-Down To Mesalamine In Pediatric Patients With Ulcerative Colitis, Reka Szigeti, Richard Kellermayer

Faculty, Staff and Students Publications

OBJECTIVE: Parents and pediatric patients with ulcerative colitis (UC) who progressed to systemic immunotherapy are concerned about lifelong risks from such treatments. There is limited knowledge about withdrawal of such agents and step-down (SD) to enteral 5-aminosalicylic acid (mesalamine) before transitioning to adult care.

METHODS: We studied nine pediatric cases with moderate to severe UC who after a median of 2.18 years of clinical remission on systemic immunotherapy stepped down to oral mesalamine treatment.

RESULTS: Average follow-up time from SD was 3.49 years. Five patients (55.5%) had sustained remission (without any flare noted) after SD during follow-up. Sustained clinical remission …

Gut Development Following Insulin-Like Growth Factor-1 Supplementation To Preterm Pigs, Martin Bo Rasmussen, Kristine Holgersen, Stanislava Pankratova, Ole Bæk, Douglas G Burrin, Thomas Thymann, Per Torp Sangild

Faculty, Staff and Students Publications

BACKGROUND: Reduced insulin-like growth factor-1 (IGF-1) levels may contribute to impaired organ development in preterm infants. Using preterm pigs as a model, we hypothesized that IGF-1 supplementation improves health and gut development during the first three weeks of life.

METHODS: First, clinical and organ endpoints were compared between artificially-reared, cesarean-delivered preterm pigs and vaginally-delivered, sow-reared term pigs at 5, 9 and 19 days. Next, preterm pigs were treated with recombinant human IGF-1 for 19 days (2.25 mg/kg/day, systemically).

RESULTS: Relative to term pigs, preterm pigs had lower body weight, fat, bone contents, relative weights of liver and spleen and a …

Improving Adherence To Clinical Practice Guidelines For Managing Gastric Intestinal Metaplasia Among Gastroenterologists At A Us Academic Institution, Jake Jacob, Valentine Millien, Scott Berger, Ruben Hernaez, Gyanprakash A Ketwaroo, Avegail G Flores, Jason K Hou, Maria E Jarbrink-Sehgal, Natalia I Khalaf, Daniel G Rosen, Hashem B El-Serag, Mimi C Tan

Faculty, Staff and Students Publications

BACKGROUND: Clinical guidelines reserve endoscopic surveillance after a gastric intestinal metaplasia (GIM) diagnosis for high-risk patients. However, it is unclear how closely guidelines are followed in clinical practice. We examined the effectiveness of a standardized protocol for the management of GIM among gastroenterologists at a US hospital.

METHODS: This was a preintervention and postintervention study, which included developing a protocol and education of gastroenterologists on GIM management. For the preintervention study, 50 patients with GIM were randomly selected from a histopathology database at the Houston VA Hospital between January 2016 and December 2019. For the postintervention study, we assessed change …

The Interplay Of Casing Material And Detonation Wave Shock Parameters In Steel Witness Plate Dent Formation, Emily M. Johnson, Catherine E. Johnson

Mining Engineering Faculty Research & Creative Works

This Study Uses Both Experimentation and Simulation to Investigate How Varying Casing Material Around Cylindrical Composition-B Charges Affects Witness Plate Response and Diagnoses the Cause of the Differences in the Dents Produced. through Experimentation, It Was Found that Consistent Dents Are Produced from Repeated Tests and Characteristically Different Dents Are Produced by Charges with Different Casing Material. Charges Cased in Viscoelastic Materials Produced Shallower Dents Than Those Without Casing. Simulation Was Validated Against the Experimental Dents, and the Detonation Wave Parameters Were Measured for 25 Differently Cased Charges: 15 Metals and 10 Polymers. Regression Fit Relationships Were Derived Relating Dent …

A Study Of Cybersecurity Landscape In The United States: Trend, Regional Variations, And Socioeconomic Factors, Trang Thi Thu Horn

All-Inclusive List of Electronic Theses and Dissertations

The Internet has become an essential part of our daily lives. Cyberspace has emerged significantly with an enormous number of users, creating a lucrative hunting field for cybercriminals. The exponential growth of internet users and online activities, along with the increased sophistication of cybercrimes, is raising significant global concerns for individuals, organizations, and governments. This research aims to explore the cybersecurity landscape in the United States, investigate regional variations, and the potential impact of the COVID-19 pandemic on the number of cybercrimes. The study utilizes a mixed research method approach, including historical analysis and a Delphi study. Historical analysis studied …

Dimensional Regularization And Two-Loop Vacuum Polarization Operator: Master Integrals, Analytic Results, And Energy Shifts, Stefano Laporta, Ulrich D. Jentschura

Physics Faculty Research & Creative Works

We Present a Complete Reevaluation of the Irreducible Two-Loop Vacuum-Polarization Correction to the Photon Propagator in Quantum Electrodynamics, i.e. with an Electron-Positron Pair in the Fermion Propagators. the Integration is Carried Out by Reducing the Integrations to a Limited Set of Master Integrals, Which Are Calculated using Integration-By-Parts Identities. Dimensional Regularization is Used in D=4-2ϵ Dimensions, and On-Mass Shell Renormalization is Employed. the One-Loop Effect is Given to Order ϵ, to Be Combined with the 1/ϵ Divergence of the Two-Loop Amplitude. Master Integrals Are Given. Final Evaluations of Two-Loop Energy Shifts for 1S, 2S, and 2P States Are Done Analytically, …

Scalar Susceptibility Of A Diluted Classical Xy Model, Reece Beattie-Hauser, Thomas Vojta

Physics Faculty Research & Creative Works

We Analyze the Amplitude Fluctuations in a Diluted 3D Classical XY Model Near the Magnetic Phase Transition, motivated by the Unusual Localization Properties of the Amplitude (Higgs) Mode Recently Found at the Disordered Superfluid-Mott Glass Quantum Phase Transition. We Calculate the Amplitude Correlation Function and the Corresponding Scalar Susceptibility by Means of Monte Carlo Simulations. in Contrast to the Quantum Case, in Which the Scalar Susceptibility Was Found to Violate Naive Scaling, We Find that the Scalar Susceptibility of the Classical System Fulfills Naive Scaling (Employing the Clean Critical Exponents, as Expected from the Harris Criterion) as the Temperature is …

Critical Risk Assessment, Diagnosis, And Survival Analysis Of Breast Cancer, Shamiha Binta Manir, Priya Deshpande

Electrical and Computer Engineering Faculty Research and Publications

Breast cancer is the most prevalent type of cancer in women. Risk factor assessment can aid in directing counseling regarding risk reduction and breast cancer surveillance. This research aims to (1) investigate the relationship between various risk factors and breast cancer incidence using the BCSC (Breast Cancer Surveillance Consortium) Risk Factor Dataset and create a prediction model for assessing the risk of developing breast cancer; (2) diagnose breast cancer using the Breast Cancer Wisconsin diagnostic dataset; and (3) analyze breast cancer survivability using the SEER (Surveillance, Epidemiology, and End Results) Breast Cancer Dataset. Applying resampling techniques on the training dataset …

Characterizing Modulators Of Protease-Activated Receptors With A Calcium Mobilization Assay Using A Plate Reader, Jacob T. Derousse, Chris Dockendorff

Chemistry Faculty Research and Publications

Changes in calcium concentration in cells are rapidly monitored in a high-throughput fashion with the use of intracellular, fluorescent, calcium-binding dyes and imaging instruments that can measure fluorescent emissions from up to 1,536 wells simultaneously. However, these instruments are much more expensive and can be challenging to maintain relative to widely available plate readers that scan wells individually. Described here is an optimized plate reader assay for use with an endothelial cell line (EA.hy926) to measure the protease-activated receptor (PAR)-driven activation of G_αq signaling and subsequent calcium mobilization using the calcium-binding dye Fluo-4. This assay has been used to …

A Comparison Of Post-Operative Pain Management Following Lumbar Laminectomy Fusions Utilizing Tlip Or Intra-Operative Local Anesthesia Block, Lauren Eberhardt, Philip Zakko, Karen Childers, Daniel Park

Conference Presentation Abstracts

Background/Introduction: Spinal fusion patients suffer significant acute post-operative pain, potentially leading to chronic pain. Opioids are commonly used for peri-operative pain management despite significant side effects. The thoracolumbar interfascial plane (TLIP) and erector spinae plane (ESP) block, alternative analgesic options with rare side effects, have proven to reduce pain and opioid consumption compared to standard non-block care. This study aimed to determine if a significant difference exists between block groups with multi- and single level laminectomy fusions in post-operative and discharge opioid consumption and length of stay. Materials/Methods: A retrospective review was performed via data query for lumbar laminectomy fusion …

Diuretic Dose Ratio Is Associated With Reduced Hospital Length Of Stay In Acute Heart Failure, Sarah Galla, Yuying Xing, Lihua Qu, David A. Berger

Conference Presentation Abstracts

Background and Objectives: Congestive heart failure (CHF) is anticipated to affect eight million Americans by 2030. Treatment for CHF exacerbation is centered around IV diuretics. There are no current studies indicating an optimal initial diuretic dose in the Emergency Department (ED), and our objective is to test our hypothesis that higher diuretic dose ratio may shorten hospital length of stay (LOS). Methods: We conducted a retrospective cohort study of a large health system from 2016 to 2022. We included patients admitted from the ED with a primary diagnosis of “CHF exacerbation” with a history of CHF and prescribed diuretics. Exclusions …

Screen Positives For Potential St-Segment Elevation Myocardial Infarction: Door To Electrocardiogram By Sex And Race, Sarah Galla, Gautam Pathak, Dalia Owda, Amit Bahl, James Ziadeh, Susan Bork, Robert Swor, Karen Childers, Maya Yiadom, David A. Berger

Conference Presentation Abstracts

Background and Objectives: Detection of ST-segment elevation myocardial infarctions (STEMI) are dependent on early acquisition of an ECG. American Heart Association guidelines require performing an ECG within 10 min for patients presenting with symptoms warranting STEMI screening. A delay in ECG acquisition causes delays in diagnosis and treatment, which is associated with worsened outcomes. However, previous work has shown there is limited success at achieving a door to ECG (D2E) time of Methods: This is a retrospective chart review study in which D2E time was measured for patients positive for STEMI ECG screening criteria in a large health system with …

Using Age-Adjusted D-Dimer Vs Traditional D-Dimer To Rule Out Acute Aortic Syndrome, Jacob Nelson, Divyani Patel, Sylvia Kashat, Gorune Geloian, Karen Childers, David A. Berger, Brett Todd

Conference Presentation Abstracts

Background and Objectives: Acute aortic syndromes (AS), including aortic dissection, are rare and life-threatening diagnoses. Early diagnosis is critical as mortality increases by 1%–2% per hour after symptom onset. D-dimer (DD) Methods: In this retrospective chart review, we identified all patients who presented to any Emergency Department (ED) at a multicenter health system between 2012 and 2021, received a D-dimer test, and underwent CTA Dissection, CTA Coronary Study, or CTA Triple Rule-Out. Patients under the age of 18, pregnant, had prior dissection or thoracic aorta repair, or who presented altered/unresponsive were excluded. For patients with multiple presentations, the first visit …

Foster Children Facing Communication Disorders, Ashlyn Carter

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

The foster care system is alarmingly overpopulated, which leads to many foster children experiencing neglect of care in many issues they face, whether medical, speech, or mental conditions; which is unacceptable. These children already face so many trials and difficulties throughout life and deserve to receive care and treatment in these situations the same as any other child. The purpose of this research is to work to make sure children who are dealing with speech and communication disorders are having those issues recognized, being taken to treatment, and being given the opportunity to fix these things, thus helping to avoid …

How Engaged Are Infants And Toddlers While Picture Book Reading?, Zoe Lawless

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

Introduction: Literacy is a very important skill that begins to be acquired at birth. Most children start to develop pre-literacy skills by being read to by their parents or other adults around them. Being read aloud to can occur at many different ages and can start as early as infancy. As children grow, they interact and engage with books in different ways. This thesis aims to investigate the read-aloud behaviors of two different groups of young children, to reveal differences in engagement interactions among infants and young toddlers when being read picture books by their teacher.

Methods: The …

Effect Of Pre-Heating On Residual Stresses And Deformation In Laser-Based Directed Energy Deposition Repair: A Comparative Analysis, Usman Tariq, Sung Heng Wu, Muhammad Arif Mahmood, Michael M. Woodworth, Frank W. Liou

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Laser-Directed Energy Deposition (DED), a Metal Additive Manufacturing Method, is Renowned for its Role in Repairing Parts, Particularly When Replacement Costs Are Prohibitive. Ensuring that Repaired Parts Avoid Residual Stresses and Deformation is Crucial for Maintaining Functional Integrity. This Study Conducts Experimental and Numerical Analyses on Trapezoidal Shape Repairs, Validating Both the Thermal and Mechanical Models with Experimental Results. Additionally, the Study Presents a Methodology for Creating a Toolpath Applicable to Both the DED Process and Abaqus CAE Software. the Findings Indicate that Employing a Pre-Heating Strategy Can Reduce Residual Stresses by over 70% Compared to No Pre-Heating. However, Pre-Heating …

A Phylogenetic Analysis Of The Population Dynamics Of A Captive Colony Of Diploptera Punctata., Nick Peterson

Theses/Capstones/Creative Projects

The unique milk production of Diploptera punctata makes this species a promising model species in entomology for studying the evolution of milk production and for insect endocrinology. Despite this, the genetic diversity of captive populations of the species is not well studied. To better evaluate the captive diversity and population dynamics of Diploptera punctata at UNO we extracted the DNA of 20 random individuals and amplified their DNA using 4 different primers before cleaning the amplified products and sequencing the genes of the samples for use in both individual and concatenated phylogenetic trees. Our results indicate the UNO colony of …

The Anti-Diabetic Drug Metformin Disrupts Feeding And Sleeping Behaviors In Drosophila Melanogaster., Lucas Fitzgerald

College of Arts & Sciences Senior Theses

Dimethylbiguanide, also known as metformin, is the single most prescribed oral treatment for non-insulin dependent diabetes mellitus, or type 2 diabetes, in Western countries. The primary mechanism of action that metformin acts through is the activation of AMP kinase, an important regulator of energy homeostasis. While the anti-diabetic effects of metformin are well documented, its effects on feeding and sleeping behaviors are not well characterized. Using the model organism Drosophila melanogaster, the mean daily quantity of food consumed was measured and compared between groups treated with several dosages of metformin. Feeding interactions such as meal frequency and length were …

Interview With Elvira Serna, Elvira Serna, Rolando Serna

ANTH 4306/6306 Anthropology of Borders

No abstract provided.

"Not That Type Of Asian": Deconstructing The Model Minority Myth From A South Asian Perspective., Shraddha Patel

College of Arts & Sciences Senior Theses

The myth of the model minority is an essential aspect of the literature on Asian American racialization. However, dominant narratives of the concept largely focus on East Asians, with limited literature highlighting its unique impact on South Asians. In light of this, this qualitative study sought to illuminate where South Asian experiences align with, deviate from, or expand upon the themes observed in existing literature. Using interview data from 21 South Asian American participants from across the United States, we explored 1) identity and sense of belonging, 2) mental health as it pertains to expectations associated with the model minority …

A Revised Synthesis Of The Cationic Lipids Dmri And Mlri, Benjamin A. Kostic

College of Arts & Sciences Senior Theses

Lipid nanoparticles (LNPs) are an increasingly utilized method of intracellular delivery for nucleic acids. The COVID-19 vaccines from Moderna and Pfizer-BioNTech have used LNP technology to combat the recent global SARS-CoV-2 pandemic, saving millions of lives.^1,2 These vaccines consist of a lipid formulation that binds to the anionic phosphate groups of mRNAs and serves as an effective way to transport the nucleic acid across membranes into cells.⁹The mRNA encodes a viral protein. When introduced to cells, the viral protein is produced so that the immune system then can generate an appropriate antibody response.³ However, this approach …

The Influence Of Smoothness And Speed Of Stand-To-Sit Movement On Joint Kinematics, Kinetics, And Muscle Activation Patterns, Woohyoung Jeon, Xuanliang Neil Dong, Ashley Dalby, Chung-Hyun Goh

Health & Kinesiology Faculty Publications and Presentations

Background: Stand-to-sit (StandTS) is an important daily activity widely used in rehabilitation settings to improve strength, postural stability, and mobility. Modifications in movement smoothness and speed significantly influence the kinematics, kinetics, and muscle activation patterns of the movement. Understanding the impact of StandTS speed and smoothness on movement control can provide valuable insights for designing effective and personalized rehabilitation training programs.

Research question: How do the smoothness and speed of StandTS movement affect joint kinematics, kinetics, muscle activation patterns, and postural stability during StandTS?

Methods: Twelve healthy younger adults participated in this study. There were two StandTS conditions. In the …