Digital Commons Network^™

Office Discipline Referral Narratives, Context, And Categorization, Deanna M. Bush

Education Dissertations

This two-part qualitative study examined the experiences of students with disabilities (SWD) in the middle school discipline. Phase one was a qualitative document analysis study that examined school discipline for SWD through the lens of Critical Disability Theory (CDT), Multi-Tiered Systems of Support (MTSS), Constructivist Learning Theory, and the Vulnerable Decision Point model (VDP) in a midsize suburban district in Washington state. The study explored alignment of ODR teacher-written narratives with behavioral categories assigned to the ODR at the time of issue to determine variance based on behavior category or student disability status. Phase two a semi-structured interview (shown on …

Chromatin Insulators Homie And Nhomie Can Interact With Distant Copies Either Together Or Separately, With Distinct Outcomes For Enhancer-Promoter Interactions, Miki Fujioka, Wenfan Ke, Paul Schedl, James B. Jaynes

Department of Biochemistry and Molecular Biology Faculty Papers

Chromatin insulators, a.k.a. boundary elements, separate regions of the chromosome with distinct chromatin characteristics, including distinct histone modifications. This activity affects gene expression by allowing chromatin domains to be stably regulated and maintained. Insulators also block enhancer-promoter interactions and, somewhat paradoxically, facilitate other interactions, particularly when they stitch together distant regions of the chromosome by pairing with specific partners. Here we explore how long-range interactions facilitated by insulator pairing are affected by the presence of two potentially competing partners. Our results show that when two partners are present, they can reduce each other's effects on distant gene expression, suggesting that …

Climate Deregulation Under Trump 2: Will It Have Any Durable Impact?, John D. Graham

Duke Environmental Law & Policy Forum

Following through on his 2024 campaign pledges, President Donald Trump is dismantling President Biden's aggressive climate policies, including federal regulatory controls on the major sectors of the economy that account for most greenhouse gas emissions in the US. Although it is too early to make a definitive assessment of what Trump will accomplish, I present evidence that Trump is taking a more creative, radical, and legally sophisticated approach to climate deregulation in his second administration than was attempted in his first administration. I evaluate how durable climate deregulation may be. A major weakness in Trump's agenda is the lack of …

The Civil Liability Gap For Oil Spills Caused By Non-State Armed Groups: The Case Of The Mv Sounion Tanker In The Red Sea, Emery Hansell

Duke Environmental Law & Policy Forum

On August 21, 2024, the Greek-flagged oil tanker MV SOUNION ("Sounion") was attacked by Houthis as it passed through the Red Sea. The Houthis, a rebel group that controls large swaths of Yemen, then set the ship ablaze, threatening to spill roughly 1 million barrels of crude oil into the water. The cleanup was anticipated to cost $20 billion. The question thus arises: who would—and who should—pay for that cleanup? At the moment, there is no effective solution.

As an initial matter, current international law focuses on State liability and is therefore unlikely to require the Houthis—as a non-State actor—to …

Phasing Out A Way Of Life: How Decarbonization Affects Coal Dependent Communities, Alex Loeb

Duke Environmental Law & Policy Forum

As member states seek to comply with European Union industry rationalization directives that will force mines that cannot compete with free-market prices without subsidies to close, domestic governments across Europe will face competing pressure from civil society. Many traditional European mining communities are dependent on the coal industry and will resist the phase out of its position in the European energy mix. In Asturias, Spain, the phase out of non-competitive coal mines has had devastating impacts on former mining towns, as they struggle to transition to a coal-free economy. After phasing out coal, Asturias has struggled with unemployment and significant …

Journal Staff

Duke Environmental Law & Policy Forum

No abstract provided.

Usa V. Daniel Wheeler

2026 Decisions

USDC for the Middle District of Pennsylvania

New Research Finds 'Hidden Housing' Along Lakes, Beth Potier

UNH Today Archive

No abstract provided.

Synthesis And Characterization Of Synergistic Bioactive– Organometallic Condensation Polymers, Francesca Isabel Mosca

Electronic Theses and Dissertations 2020 - Present

This research focuses on the synthesis and structural characterization of polymers with anticipated anticancer and antiviral properties by combining metal-containing Lewis acids, organotin dichlorides (R2SnCl2), Group 4 metallocene dichlorides (Cp2TiCl2, Cp2ZrCl2 and Cp2HfCl2), and triphenyl Group 15 metal dichlorides (Ph3AsCl2, Ph3SbCl2 and Ph3BiCl2), with biologically active Lewis bases, lamivudine, a synthetic nucleoside, and camphoric acid, a dicarboxylic acid, to achieve synergistic effect.

Five classes of polymers were synthesized using interfacial polymerization: lamivudine and organotin dichlorides, lamivudine and Group 4 metallocene dichlorides, camphoric acid and triphenyl Group 15 metal dichlorides, camphoric acid and organotin dichlorides, and camphoric acid and Group 4 …

A Machine Learning Framework For Contractor Scope Matching Using Profile Characteristics And Work Package Vector Similarity, Pedro Fonseca, Sergei Chuprov

Computer Science Faculty Publications

This paper presents a machine learning-based framework for predicting contractor performance in the construction industry by integrating contractor profile information with work package characteristics. The proposed approach addresses procurement challenges arising from the misalignment between contractor expertise and assigned scopes, a key contributor to cost overruns and schedule delays. Unlike existing models that rely on aggregated project-level indicators, the framework enables scope-aware performance prediction by leveraging the Work Breakdown Structure (WBS) to capture similarity among work packages. Contractor profiles are encoded using historical performance data, while WBS elements are vectorized to quantify scope similarity and contextualize predictions. Experimental results demonstrate …

Case Study Answers Are Not Elementary: How A Positive Outlier K-5 School Beat The Odds, Douglas Aaron Ferguson

Education Dissertations

There are a limited number of case studies of positive outlier elementary schools, otherwise known as schools that are beating the odds, and more of such studies are needed in order to effectively replicate positive problem-solving solutions. Positive outlier schools and districts, the focus of this dissertation, are those that score significantly above demographically similar schools and districts on standardized state testing. For example, none of the existing case studies highlight organizational culture as a key factor despite the fact that many of the more targeted topically focused studies cite school culture as a top factor. Additionally, the longest running …

Monoclonal Antibodies Targeting Pcdh7 Inhibit Tumor Growth And Enhance Immune Responses In Kras-Mutant Non-Small Cell Lung Cancer, Nicole Novaresi, Poorva Ghosh, Shayna Thomas-Jardin, Hui Deng, Xuejun Fan, Zhiqiang Ku, Wei Xiong, Xiaorong Zhou, Jingfei Zhu, Huiyu Li, Mahesh S Padanad, Bethany Smith, Chul Ahn, John D Minna, Zhiqiang An, Ningyan Zhang, Kathryn A O'Donnell

The Brown Foundation: Institute of Molecular Medicine

We identified an important oncogenic role for protocadherin 7 (PCDH7), a cell surface protein frequently overexpressed in lung adenocarcinoma and associated with poor clinical outcome. Pcdh7 depletion reduces tumor burden and prolongs survival in KrasLSL-G12D; Tp53fl/fl mice. These findings nominate this cell surface protein as an actionable therapeutic target and highlight the therapeutic potential of PCDH7 inhibition for non–small cell lung cancer. We report the development and characterization of high-affinity anti-PCDH7 monoclonal antibodies (mAbs) that inhibit downstream mitogen-activated protein kinase (MAPK) pathway activation and suppress tumor growth in multiple mutant KRAS–driven models. A lead mAb (mAb7) sensitized tumors …

Amc-F1 Regulates Mitochondria-Autophagy Crosstalk Independent Of Nutrient Stress, Yuqin Wang, Raksha K Rao, Trung Vu, Ayano Sekine, Zhengmei Mao, Nami Mccarty

The Brown Foundation: Institute of Molecular Medicine

Mitochondria and autophagy are fundamental yet distinct regulators of cellular homeostasis. Here, we identify AMC-F1 (Autophagy-Mitochondria Coupling Factor 1; formerly TRIM44) as a central integrator of mitochondrial bioenergetics and autophagy. Using Amcf1 knockout and knock-in mouse models, we demonstrate that AMC-F1 bidirectionally regulates these pathways: its loss reduces mitochondrial respiration and autophagic flux, whereas its overexpression promotes mitochondrial elongation and increases autophagy independently of nutrient stress. Transcriptomic analyses reveal AMC-F1-dependent regulation of mitochondrial biogenesis programs that engage autophagy, involving mitochondrial respiratory chain complex genes under basal conditions and mitochondrial organization factors under starvation-induced autophagy. Although dispensable under homeostasis, this coupling …

Statistical Methods In Research, Horahenage Dixon Vimalajeewa

UNL Faculty Course Portfolios

This course portfolio documents the design, delivery, assessment, student-learning evidence, and reflective evaluation of STAT 801A-700: Statistical Methods in Research, an online asynchronous service course designed to introduce students from diverse disciplinary backgrounds to foundational statistical reasoning and applied data analysis. The course is a non-calculus-based introduction to statistical methods used to answer research questions, with emphasis on collecting, organizing, describing, analyzing, and drawing conclusions from data. The course also emphasizes applications relevant to biology, agriculture, and other research-oriented fields. This is an online distance course aimed to develop students’ understanding of basic probability and statistical concepts, recognize the importance …

Course Portfolio: Elements Of Physics Phys 151, Evan A. Rich

UNL Faculty Course Portfolios

This course portfolio documents the instructional design, teaching methods, and ongoing assessment efforts for PHYS 151: Elements of Physics, an algebra-based introductory physics course at the University of Nebraska-Lincoln. The course serves a broad undergraduate population, including architecture, construction management, and life science majors. The portfolio describes the teaching framework that integrates pre-lecture video preparation, active in-class engagement through iClicker questions, and collaborative weekly recitation sections, all unified around a structured six-step problem-solving approach. A central concern of the course is building students’ self-efficacy in physics, particularly among those with math anxiety or limited preparation. Two assessments are reported: a …

Automated Physical Activity Support For Adults And Youth From Low-Income Communities: Single-Arm Pilot Study., Jordan A. Carlson, Frank T. Materia, Mallory Moon, Suryeon Ryu, Cory Yeager, Chelsea Steel, Kacee Shields, Harpreet Singh Gill, Jannette Berkley-Patton, Delwyn Catley

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Mobile health (mHealth) interventions are growing in popularity, but less research has focused on low-income families, particularly interventions integrating wearable devices with automated personalized messages.

OBJECTIVE: We tested a preliminary wearable-integrated mHealth intervention with initial personalization elements among adults and youth from low-income urban communities, focusing on feasibility, acceptability, and preliminary evidence of physical activity behavior.

METHODS: Participants were 83 adults and 31 youth recruited through community health events held in low-income urban communities. Using a single-arm pre-post design, participants were enrolled into a 7-week beta-version mHealth intervention that integrated a Garmin activity monitor with automated text messages. Messages …

Targeted Reflex Rna Sequencing For Enhanced Variant Classification On Exome And Genome Sequencing Improves Patient Outcomes, Sydney Lau, Mei Ling Chong, Jason Chibuk, Hongzheng Dai, Wilson C W Wu, Christina Peroutka, Laura Famularo, Alexander Y Kim, Bailey Hummel, Sarah Dugan, Tinsley Douglas, Linyan Meng, Fan Xia, Christine M Eng

Faculty, Staff and Students Publications

RNA sequencing (RNA-seq) has been utilized to provide functional evidence regarding the impact of splicing variants. This study explores the utility of targeted reflex RNA-seq to inform classification of predicted splicing variants identified through clinical exome sequencing (ES) and genome sequencing (GS). A retrospective analysis was conducted on consecutive ES/GS cases completed at a single center in which targeted reflex RNA-seq was performed following identification of eligible variants. There were 131 cases (4.1%) that had at least one RNA-seq eligible variant reported, with eight of these cases having two unique eligible variants. Of the 139 eligible variants, 125 were classified …

Histone Deacetylase Enzyme Activity Is Not The Universal Anticancer Target Of Hdac Inhibitors, Wenbo Li, Hyun-Hwan Jeong, Chengchuang Song, Panpan Liu, Yingjie Chang, Hao Fang, Udhaya Kumar S, Yuxiang Sun, M James You, Dongyin Guan, Zhandong Liu, Leng Han, Xuben Hou, Zheng Sun

Faculty, Staff and Students Publications

Histone deacetylase inhibitors (HDIs) are approved for treating hematologic cancers and are currently being evaluated in hundreds of clinical trials for various cancers and other diseases, although their mechanisms of action remain poorly understood. Here, our unbiased bioinformatics analyses found that, for most cancer types, expression levels or genetic variants of histone deacetylase (HDACs) do not consistently correlate with carcinogenesis, do not predict cancer patient survival, and do not associate with cellular responses to HDIs. Whole-genome CRISPR library screens did not identify HDACs as genes affecting cellular responses to HDIs. Overexpression of dominant-negative Class I HDACs causes similar protein hyperacetylation …

Uncovering Dkk1 As A Therapeutically Relevant Target In Aggressive Er+ Breast Cancer Using A Novel Antiestrogen, Kristen Young

Dissertations

Over 70 percent of breast cancers are estrogen receptor-positive (ERα+), meaning that the hormone estrogen drives tumor growth. Although first-line targeted therapies that directly block ERα from hormone-dependent pathologies are initially effective, almost half of patients ultimately progress. These patients show high mutational rates to the ESR1 gene that encodes for ERα. A hotspot missense tyrosine to serine mutation at position 537 (Y537S) initiates hormone-independent, allele-specific transcriptional programs that increase metastasis. While next-generation ERα-targeted therapies show promise, benefits are often limited compared to standard-of-care. Understanding the mechanisms of action used by the Y537S ESR1 breast cancer cells to evade therapeutic …

Disease-Causing Mfn2 Mutants Impair Mitochondrial Fission Dynamics By Distinct Drp1 Dysregulation, Daniel Lagos, Pamela R. De Santiago, Nicolás Pérez-Bravo, Benjamín Cartes-Saavedra, Josefa Vial-Brizzi, Diego Troncoso-Chandía, Oliver Podmanicky, Rita Horvath, Verónica Eisner

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Mitochondria undergo fusion and fission. While DRP1 regulates fission, fusion is controlled by OPA1, MFN1, and MFN2. The balance between these processes and the crosstalk between machineries remains poorly understood. MFN2 mutations cause Charcot-Marie-Tooth disease type 2 A (CMT2A), affecting mitochondrial fusion and morphology. However, their role in fission is unclear. Using skin fibroblasts from CMT2A patients (L248H and M376V MFN2 mutations) and wild-type mouse embryonic fibroblasts expressing these variants, we studied how MFN2 mutations impact mitochondrial dynamics beyond fusion. We analyzed mitochondrial morphology and dynamics by live-cell confocal microscopy and tested fusion/fission protein levels, oxygen consumption rate (OCR), extracellular …

Recommendations For Disclosure Of Artificial Intelligence In Scientific Writing And Publishing: A Regional Anesthesia And Pain Medicine Modified Delphi Study, Michael Gofeld, Hannah Lonsdale, Brittani Bungart, Christopher P Cheng, Garrett W Burnett, Lichy Han, Matthew Wiles, Steve Coppens, Thomas Joseph, Kristin L Schreiber, Thomas Volk, Richard D Urman, Vesela P Kovacheva, Christopher L Wu, Edward R Mariano, Vivian H Y Ip

Faculty, Staff and Student Publications

Introduction: The use of artificial intelligence (AI) in the scientific process is advancing at a remarkable speed, thanks to continued innovations in large language models. While AI provides widespread benefits, including editing for fluency and clarity, it also has drawbacks, including fabricated content, perpetuation of bias, and lack of accountability. The editorial board of Regional Anesthesia & Pain Medicine (RAPM) therefore sought to develop best practices for AI usage and disclosure.

Methods: A steering committee from the American Society of Regional Anesthesia and Pain Medicine used a modified Delphi process to address definitions, disclosure requirements, authorship standards, and editorial oversight …

Why Are Some Children Under 24 Months Still Undernourished In Urban And Peri-Urban Vientiane? A Mixed-Methods Study, Kethmany Ratsavong, Dirk Essink, Pamela J. Wright Phd, Ms, Med, Rn, Cen, Somphou Sayasone, Sengchanh Kounnavong, Jacqueline E. Broerse

Publications

Child undernutrition remains a significant public health challenge in many low and middle-income countries (LMICs), including Lao PDR, where high levels persist even in urban areas with generally available and accessible food. This study aimed to explore factors underlying the persistently high rates of undernutrition among young children in urban (Saysetha) and peri-urban (Pakgneum) districts of the Vientiane Capital in Lao PDR. A cross-sectional survey employed a sequential explanatory mixed-methods approach, combining a structured questionnaire of 333 mother-child pairs for quantitative analysis with semi-structured interviews of 47 caregivers for qualitative insights. The prevalence of malnutrition among children under 24 months …

Detectability Of Polarized Γ-Ray Emission From Blazar Flares With Cosi, Garrett A. Latiolais, Jorge Otero-Santos, Michela Negro, Lea Marcotulli, Mohammad Ali Boroumand, Savitri Gallego, Tiffany Lewis, Et Al.

Michigan Tech Publications

We investigate the detectability of polarized γ-ray emission from blazar flares with the Compton Spectrometer and Imager (COSI). Using 17 yr of Fermi Large Area Telescope observations, we analyze light curves for 1413 blazars and identify a maximum of 787 sources with flaring episodes through Bayesian block analysis. For each flare, we estimate the minimum detectable polarization (MDP99%) in the COSI energy band (0.2–5 MeV) using instrument response functions under a range of spectral assumptions and background conditions. Under baseline background levels (1 count s⁻¹) and assuming that blazar flare statistics in the MeV band are comparable to …

Decoding Growth Hormone Actions On Human Growth Plate Stem Cells

Faculty, Staff and Student Publications

The epiphyseal growth plate is the key target of growth hormone (GH) therapy. Although growth plate stem cells are well defined in mice, their presence in humans was unclear. Using rare surgical specimens, the study by Chu et al. reveals conserved, GH-responsive stem cells in the human pubertal growth plate.

Racism In The Science And Practice Of Psychotherapy, Richard E. Redding, Craig L. Frisby

Psychology Faculty Articles and Research

We discuss a recent controversy that occurred in The Cognitive Behavioural Therapist over whether Lilienfeld’s critical views on microaggressions theory and research reflect racist beliefs, as alleged by some. This is one of many recent examples of a profoundly antiscientific practice whereby racism allegations chill scientific debate and open inquiry on important research issues. This produces an overtly politicized science that has a corrosive effect on scientific progress and ultimately the useful application of research in clinical practice. The microaggressions controversy provides an especially useful vehicle for challenging this state of affairs given the widespread application of microaggressions theory, including …

Quantitatively Hyper-Positive Real Rational Functions Iii, Daniel Alpay, Izchak Lewkowicz

Mathematics, Physics, and Computer Science Faculty Articles and Research

Hyper-Positive Real, matrix-valued, rational functions are associated with absolute stability (the Lurie problem). Here, quantitative subsets of Hyper-positive functions, related through nested inclusions, are introduced. Structurally, this family of functions turns out to be matrix-convex and closed under inversion. A state-space characterization of these functions through a corresponding Kalman-Yakubovich-Popov Lemma, is given. Technically, the classical Linear Matrix Inclusions, associated with passive systems, are here substituted by Quadratic Matrix Inclusions.

Participants’ And Physiotherapists’ Views On The Delivery Of A Randomised Controlled Feasibility Trial Investigating A Bespoke Dynamic Elastomeric Fabric Orthosis For Women With Chronic Pelvic Girdle Pain: A Qualitative Exploration, Bradley Halliday, Jennifer Freeman, Sarah Chatfield, Lee Cameron, Kirsty Carter, Joanne Hosking, Jill Shawe

School of Health Professions

Background: Chronic pregnancy-related pelvic girdle pain (PPGP) affects approximately 10–30% of postpartum women beyond 3 months. Such pain is typically recalcitrant to standard care. A dynamic elastomeric fabric orthosis (DEFO) is one option. A feasibility randomised controlled trial (fRCT) assessed the feasibility and acceptability of trial design, interventions and data collection. The aim of this qualitative sub-study was to explore the experience of women participating in the feasibility trial, and physiotherapists delivering the trial intervention. Methods: An embedded qualitative study within a fRCT. The fRCT randomised participants to either control (standard care involving advice and exercise) or intervention (standard care …

A Scoping Review Of Ai Literacy: Implications For Governance And Public Policy, Anabel Quan-Haase, Katharine Willis, Hillary Anderson, Selena Gignac, Takuya Maeda

School of Art, Design and Architecture

AI literacy can be situated at the intersection of other types of literacy such as media literacy anddigital literacy, but the concept is distinct. What complicates our understanding of AI literacy is thatAI is highly opaque and black-box, creating obstacles to grasping what these systems are doing andhow (Burrell, 2016; Petrovčič, et al. 2024). This requires an interdisciplinary effort in conceptualizingand mapping AI literacy. Based on our analyses of the current literature, we see five different typesof conceptualizations of AI literacy:1.Competency-based approaches: focused on skills, knowledge, and ethical use of AI.2.Awareness-oriented approaches: centered on recognizing the presence and influence of …

The Employment Situation Of Veterans: May 2026, Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

The May 2026 employment report highlights improving labor conditions for U.S. veterans, with unemployment declining from 3.6% in April to 3.2% in May..pdf) Despite this progress, Post-9/11 veterans experienced a slight increase to 4.1%. Younger veterans continue to face higher unemployment rates than their nonveteran peers, while older veterans maintain relatively low rates. Long-term unemployment remains a concern, with over half of unemployed veterans out of work for 15 weeks or more. Unemployment decreased across most demographic groups, including women and minority veterans, often falling below nonveteran rates, indicating gradual but uneven improvement in veterans’ employment outcomes nationwide.

Chatgpt, Where Should I Go? A Qualitative Exploration Of How Large Language Models Are Experienced As Support For Travel Planning, Mohammad Amin Kuhail, Asbjørn Følstad, Saifeddin Alimamy

All Works

Large language models (LLMs) are increasingly used for travel planning. Yet, little is known about how travellers experience and interact with such language models. This qualitative study explores how users employ LLMs to plan trips, drawing on the hedonic/pragmatic model of user experience to examine functional and affective dimensions. We collected data from 104 participants with prior experience using LLMs for travel advice through open-ended questionnaire responses. Thematic analysis revealed three key insights: (1) users value the pragmatic benefits of LLMs, such as efficiency, clarity, and confidence in decision-making, while also appreciating hedonic qualities, including inspiration, enjoyment, and authenticity; (2) …