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Clinical Outcomes And Complication Rates When Using Lyoplant Onlay Between Serial Craniectomy And Cranioplasty: A Single-Center Experience, Nathaniel Neavling, Manisha Koneru, Hamail Iqbal, Joseph Ifrach, Clint Badger, Corey Mossop, Ajith Thomas, Daniel Tonetti

Research Day

Introduction: Decompressive craniectomy is a pervasive treatment modality for malignant ischemic stroke and traumatic injury. Usage of dural substitute onlay during craniectomy closure is largely determined by provider preference. Complication rates and clinical outcomes associated with Lyoplant (Aesculap, Center Valley, PA, USA) onlay is currently not well characterized. Here, we examined the rate of complications and clinical outcomes in craniectomies performed with either Lyoplant or another dural substitute.

Methods: Patients undergoing cranioplasty following either ischemic stroke or traumatic injury at a single site were analyzed between December 2013 and June 2023. Mann-Whitney U tests and Fisher’s exact tests were performed …

Premature Closure Of The Ductus Arteriosus As A Cause Of Intrauterine Fetal Demise: A Case Report, Amélie Harpey, Walter Kobasa, Noel Anupol

Research Day

INTRODUCTION

The ductus arteriosus (DA) is a cardiac structure present in utero, allowing for the bypass of the pulmonary circulation during fetal development. The DA closes within 24-48 hours of birth. DA patency is maintained in utero by a low oxygen gradient in the blood, endothelial NO production, and prostaglandins E1 and E21. Premature closure of the DA is a rare condition and can be idiopathic, a result of abnormal levels of circulating prostaglandins, or secondary to maternal ingestion of non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, or polyphenol-rich foods2. Prenatal closure of the DA can lead to cardiovascular dysfunction, resulting in …

Quantifying Pthlh And Ihh Gene Expression In The Growth Plate Forming And Non-Forming Ends Of The Mouse Metatarsal, Maria Biancaniello, Sherrie Wallace, Sarah Doelp, Kelsey M. Kjosness, Philip Reno

Research Day

INTRODUCTION: The Parathyroid hormone-related protein (PTHrP, the product of the Pth-like hormone, Pthlh, gene)/Indian hedgehog (Ihh) feedback loop is a fundamental regulator of skeletal growth plates. The chondrocytes within the growth plate undergo the sequential resting, proliferative, and hypertrophic stages before being replaced by bone. Just prior to undergoing hypertrophy, pre-hypertrophic chondrocytes express Ihh, which signals back to resting cells to promote the expression of Pthlh. PTHrP then signals proliferating chondrocytes to limit their differentiation to hypertrophy and maintain a pool of mitotic cells in the growth plates of typical long bones. However, the metatarsals (MT) do not grow like …

Improvement In Coma Recovery Scale-Revised Score Following Trendelenburg Positioning In Syndrome Of The Trephined: A Case Report, Jesus Alvarado Salinas, Kayla Davenport, Ranjeev Chabra, Mithra B. Maneyapanda

Research Day

Disclosures: None

Setting: Inpatient Rehabilitation Facility

Patient: 44-year-old woman status post decompressive hemicraniectomy with suspected syndrome of the trephined.

Case Description: The patient sustained a non-traumatic brain injury secondary to ruptured right posterior communicating artery aneurysm. She required aneurysm coiling and right decompressive hemicraniectomy. Her course was complicated by right hemispheric strokes, seizures, and hydrocephalus requiring ventriculoperitoneal shunt (VPS) placement. She was admitted to inpatient rehabilitation for a specialized disorder of consciousness (DOC) program 6 weeks after the initial bleed. Her initial Coma Recovery Scale-Revised (CRS-R) score was a 3 of 23 indicating unresponsive wakefulness syndrome (UWS).

Assessment/Results: Patient remained …

Vesicular Eruption In A Woman With Systemic Lupus Erythematosus, Shane B. Devine, Harold Essenfeld, Katrina Hansen

Research Day

Introduction

Bullous systemic lupus erythematosus (BSLE) is a rare autoimmune blistering disorder that presents as a vesiculobullous eruption in around 5% of patients with a known diagnosis of systemic lupus erythematosus (SLE). The incidence of BSLE is greater in middle aged, African-American females. In some cases, BSLE is the initial clinical presentation leading to a SLE diagnosis. The development of BSLE may be associated with active extra-cutaneous manifestations of SLE, so a prompt diagnosis of BSLE is crucial to prevent any further complications of SLE. We present a case of a vesicular eruption in a woman with a previous diagnosis …

Childhood Obesity Treatment And Approach Quality Improvement Project, Kimberly Townsend, Autumn Dye

Research Day

Introduction

Childhood obesity has become an important public health issue in the United States. Obesity is defined as a BMI at or above the 95th percentile for age and sex. Childhood obesity can be associated with many comorbidities and adverse effects, including type 2 diabetes, hypertension, nonalcoholic fatty liver disease, obstructive sleep apnea, and dyslipidemia.

Methods

The data was taken from data collected throughout 2023 and 2024 from the AAP QI project on childhood obesity and treatment. The data was collected from charts at PCOM’s Lancaster Avenue clinic. Additional methods will include a literature review to outline the importance of …

Treatment Of Rosacea During Pregnancy: A Literature Review, Emily M. Garelick, Margaret C. Hurley, Lauren Noto-Bell

Research Day

Rosacea is a chronic inflammatory skin condition that affects the face and presents in many forms, including pustules, papules, painful erythema, edema, and more. The pathogenesis of rosacea is largely undetermined, but general mechanisms include immune dysregulation, neurovascular reactivity, skin barrier dysfunction and demodex infestation, genetics, and certain environmental triggers. Rosacea is commonly exacerbated during pregnancy, but the lack of treatments that are safe for a developing fetus poses a problem for patients and their physicians. The go-to treatment for rosacea consists of a variety of topical and oral antibiotics and anti-inflammatory medications that are typically not recommended for use …

The Prevalence Of Demodex Folliculorum And Brevis Colonization In Patients Presenting With Blepharitis To An Outpatient Resident Clinic, David Broytman, Eric Rosenberg, Alanna Nattis, Ryan Kent, Vinh Ngo

Research Day

Purpose: To examine the prevalence of Demodex in two large, tertiary care, outpatient resident clinic settings; meanwhile, exploring demographic variables, use of ocular medications, and OTC cosmetic products with respect to prevalence. Lastly, analyze potential inadequacies in the rate of treatment amongst patients in the resident clinic setting.

Methods: A cross-sectional non-randomized, prospective study investigating the prevalence of Demodex folliculorum (DF) and brevis (DB) in patients presenting with blepharitis, and in control patients without clinical evidence of dry eye blepharitis syndrome (DEBS). Epilation of one eyelash from each lid was performed and studied under high power light microscopy. Each patient …

Analyses Of The Correlation Of Hpv Vaccination And Oropharyngeal Cancer/Lesion In Men: From Allofus Research Database, Anna M. Terzian, Ahmad B. Cader, Qian Chen

Research Day

Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. It is most well-known as the leading cause of cervical cancer. However, there is a rising prevalence of HPV-related oropharyngeal cancers, particularly in men from high-income countries. Therefore, it is urgent to advocate prevention. This study aims to understand the correlation between the HPV vaccination and reduced HPV-related oropharyngeal cancer development. Additionally, many factors, such as race, income, risky sexual behavior, smoking, and recreational drugs are worth analyzing to appreciate their role in cancer development. This study was conducted using the AllofUs research database. The keywords included …

Challenges In Capacity: A Case Report Exploring Social Determinants Of Health And Psychiatric Illness, Hunter Smith, Jacob Light, Jenys Allende

Research Day

I. Introduction

An assessment of capacity is a critical part of the surgical consent process in order to ensure that the patient understands the risks, benefits, and alternatives to treatment. When a patient refuses life-saving care, it is essential to evaluate them to determine their capacity for decision-making. While there are specific components to a capacity evaluation, the capacity assessment process can be clouded by other factors in the patient’s history. The purpose of this case study is to illuminate the myriad challenges faced by surgeons assessing capacity in patients with complex social and psychiatric backgrounds.

II. Case

A 53-year-old …

Postoperative Stomach Volvulus And Pancreatitis Following A Sleeve Gastrectomy, Shane B. Devine, Sam J. King, Bradley J. Chatterton, Kurt Knepley

Research Day

Introduction

The laparoscopic vertical sleeve gastrectomy is the most common bariatric procedure performed globally. The greater curvature and fundus of the stomach are stapled off and removed, forming a narrower and less distensible stomach, resulting in reduced caloric intake. Postoperative complications include gastroesophageal reflux disease, leakage of the staple line, intraluminal and intra-abdominal bleeding and porto-mesenteric vein thrombosis. Additionally, gastric obstruction has been reported as a complication in 0.2-4% of cases. Most obstructions are due to either mechanical narrowing or malrotation of the sleeve caused by improper alignment of the staples. We present a patient with gastric outlet obstruction missed …

Double Crush Syndrome Presenting As Foot Drop Due To A Peroneal Neuropathy And An L5 Radiculopathy: A Case Report, James Petrera, Ronald Lincow

Research Day

Introduction: The purpose of this research is to describe a patient who presented with double crush syndrome that originally presented with signs and symptoms of a peroneal neuropathy at the fibular head. However, Electromyography (EMG) later confirmed an L5 lumbar radiculopathy. In this case report, we aim to present a rare occurrence which has been recognized, however, very few detailed reports exist.

Case Description: This is a case report of a 77-year-old male farmer who presented to the private practice with complaints of right foot-drop and bilateral low back pain. These symptoms began after falling off a ladder about 2 …

Academic Degree Bias Among Speaking And Leadership Roles At The American Academy Of Orthopaedic Surgeons Annual Meeting 2016-2021, Lucas Bartlett, Alton Daley, Adam Kazimierczak, Brandon Klein, Casey Humbyrd, Adam Bitterman, Randy Cohn

Research Day

Objective: This study examined the proportion of osteopathic physicians (DO) across various speaking and leadership roles at recent American Academy of Orthopaedic Surgeons (AAOS) annual meetings.

Design: Meeting programs from the AAOS were publicly accessed and compiled between 2016 and 2021. Two categories of AAOS meeting participants were created. Invited speaker and faculty roles included moderators of symposia and program committee members while authors of presented papers were classified into academic roles. The proportion of DOs in each role type (invited speaker, academic) were recorded for each meeting program. The representation of DO's in these roles were then examined longitudinally …

Protein Kinase C Epsilon Peptide Inhibitor Conjugated With Myristic Acid And Trans-Activator Of Transcription Attenuates Myocardial Ischemia-Reperfusion Injury In A Porcine In Vivo Model, Logan T. Clair, Sunit G. Singh, Tameka C. Dean, Desmond Boakye Tanoh, Kayla Harrell, Arjun Nair, Cameron Stinson, Annam Humayun, Qian Chen, Robert J. Barsotti, Lindon H. Young

Research Day

Protein Kinase C epsilon (PKCε) signaling is known to mediate superoxide production from mitochondrial and uncoupled endothelial nitric oxide synthase sources in myocardial ischemia-reperfusion (I/R) injury. Previously, PKCε peptide inhibitor conjugated with myristic acid and trans-activator of transcription (N-Myr-Tat-CC-EAVSLKPT [PKCε-]; Myr-Tat-PKCε-) exhibited profound reduction in infarct size compared to Myr-PKCε- or Tat-PKCε- in ex vivo rat hearts♰. This study aims to evaluate the effects of Myr-Tat-PKCε- in porcine myocardial I/R in vivo compared to a scrambled control peptide.

Male Yorkshire castrated pigs (38-54kg) were subjected to regional I(1hr)/R(3hrs) via catheter-balloon in the left anterior descending coronary artery (LAD) at the …

Management Of Large Bladder Calculi Utilizing Dual-Action Percutaneous Lithotripsy Via Suprapubic Tube Sheath: A Novel Technique, Kayla G. Meyer, Kristofer Muzzi, Nicole Ambrose, Zachary Snow, Zachariah Taylor, Teodora Schellato, Noah R. May

Research Day

Introduction:

Development of bladder calculi is a common occurrence in patients with poor bladder emptying or retained foreign bodies within the bladder. These calculi cause irritative voiding symptoms and increase the likelihood of refractory urinary tract infections. Many techniques exist to treat bladder calculi, including endoscopic and open-surgical approaches. We present a novel technique to treat exceptionally large or difficult-to-treat bladder calculi.

Methods:

The study included three patients with bladder calculi ranging from 1.3 cm to 6.8 cm. The novel technique involved percutaneous access to the bladder using a suprapubic tube (SPT) trocar and sheath, enabling the use of a …

Comparing Practice Patterns In Acute Ischemic Priapism Management, Sami Musallam, Kayla Meyer, Noah May

Research Day

Introduction:

While AUA guidelines recommend a specific protocol for managing acute ischemic priapism, its implementation varies between emergency department (ED) providers and urologists. The absence of well-established dosing guidelines for phenylephrine further compounds its variability. Our study aims to assess the divergence in practice patterns between ED staff and urologists in the management of priapism, with a particular focus on the use of corporal blood gas and intracavernosal (IC) phenylephrine injection.

Methods:

We queried Epic electronic health records (EHR) from four Philadelphia area community hospitals for ED encounters with priapism ICD-10 codes between January 2018 and February 2023. Exclusions included …

Surgically Treated Ischial Tuberosity Avulsion Fractures In Adolescents: Risks And Outcomes Of Three Fixation Constructs, Brendan A. Williams, Matthew Titus, Nathan Chaclas, Kathleen J. Maguire, J. Todd Lawrence

Research Day

Background:

Avulsion fractures of the ischial tuberosity (AFIT) are uncommon injuries that sometimes require operative fixation for significant displacement and/or associated neurologic symptoms. Various fixation methods have been utilized, including screws, suture anchors, and cortical suspensory buttons. The purpose of this study is to review a consecutive series of surgically managed AFITs at a single institution and compare outcomes among fixation strategies. We hypothesized there would be no difference in outcomes between fixation types.

Methods:

We conducted a retrospective review of all patients treated operatively at a single institution from 2010-2022 for AFIT identified by CPT code (27215). We collected …

Body Mass Index Does Not Predict Injury Pattern Or Outcome After Motorcycle Crash, Madison E. Morgan, Lindsay Periera, Anthony Allsbrook, Jennifer Q. To, Odessa R. Pulido, Hannah Shin, Alison Muller, Adrian Ong, Christopher A. Butts, Maxwell A. Braverman

Research Day

Introduction: The obesity epidemic plagues the United States, affecting approximately 42% of the population. The relationship of obesity with injury severity and outcomes has been poorly studied among motorcycle collisions (MCC). This study aimed to compare injury severity, mortality, injury regions, and hospital and intensive care unit length of stay (LOS) between obese and normal-weight MCC patients.

Methods: Trauma registries from three Pennsylvania Level 1 trauma centers were queried for adult MCC patients (January 1, 2016-December 31, 2020). Obesity was defined as adult patients with body mass index 30 kg/m2 and normal weight was defined as body mass index/m2 but …

Naltrindole Inhibits Phorbol 12-Myristate 13-Acetate-Induced Superoxide Release By A Novel Mechanism Related To Reduced Intracellular Calcium Levels In Polymorphonuclear Leukocytes, Jennifer Dang, Cameron Stinson, Devani Johnson, Mai A. Le, Logan Clair, James Ramsarran, Desmond B. Tanoh, Annam Humayun, Alexandra Barrera, Juliet Melnik, Tameka Dean, Qian Chen, Robert J. Barsotti, Lindon H. Young

Research Day

Introduction:

We recently showed that naltrindole (NTI) 100-200µM attenuated phorbol 12-myristate 13-acetate (PMA) induced polymorphonuclear leukocytes (PMNs) superoxide (SO) release by a novel mechanism of action (MOA) devoid of opioid receptors. We hypothesize that NTI’s novel MOA is a reduction of intracellular calcium (Ca2+). To test this hypothesis, we conducted PMA-induced PMN SO release using KB-R7943(KB). KB is known to reduce intracellular Ca2+ via inhibition of reverse mode Na+/Ca2+ exchanger and is used as a positive control to attenuate PMA-induced PMN SO release. Naloxone (NX), a broad-spectrum opioid receptor antagonist, is used as a negative control and should have no …

Pituitary Apoplexy Presenting With Acute Onset Complete 3rd Cranial Nerve Palsy, Justin M. George, Yoona Choe, Matthew J. Boyle, Peter Maduka

Research Day

INTRODUCTION: Pituitary adenomas, arising from the pituitary adenohypophyseal cell, are commonly classified by cell type, size, and hormone secretion. Approximately 48% are macroadenomas (≥10 mm), with around 53% being prolactinomas. Despite their frequency, only 1 in 1100 individuals show clinical symptoms, making detection challenging. These adenomas pose an additional risk, with up to 27.6% developing apoplexy—a medical emergency due to acute hemorrhage or infarction leading to gland necrosis. Symptoms vary widely, including sudden headache, altered mental status, visual impairment, ophthalmoplegia, or hormonal dysfunction, depending on mass effect compression. Less commonly, the tumor invades the cavernous sinus, causing cranial nerve palsies. …

Uncommon Presentation Of A Chronic Recurrent Symptomatic Encapsulated Calcified Post-Operative Paraspinal Lumbar Hematoma: A Case Report, Shaan Sadhwani, Timothy Edwards, Antonio J. Almeda-Lopez, Brendan Swenney, Walter C. Peppelman, William J. Beutler

Research Day

Purpose:

This report highlights the uncommon presentation of postoperative recurrent calcified lumbar paraspinal hematoma. In doing so, we explore the details surrounding this phenomenon and describe the operative management utilized.

Background:

Paraspinal hematoma can be a common complication following spine surgery. However, most of these hematomas are asymptomatic and reabsorbed. There is a paucity of literature that describes the recurrence of these hematomas in a chronic setting and management when this situation is encountered. This case report describes a patient with a chronic recurrent calcified paraspinal hematoma that first developed over 4 years and then reoccurred 11 years later at …

Comparative Analysis Of Caffeine Therapy Guidelines In Neonates, Abigail E. Vangorder, Brandon Poterjoy

Research Day

INTRODUCTION:

Clinical guidelines are utilized in the effort to practice evidence-based medicine. Despite caffeine citrate’s common use in the treatment of apnea of prematurity (AOP) in neonates, there is not a commonly adopted clinical guideline for caffeine therapy. We aim to explore how variation in cited sources influences variation in published recommendations for caffeine therapy in the treatment of apnea of prematurity.

METHODS:

We utilized comparative analysis to identify qualitative variances in clinical guidelines for caffeine therapy to treat apnea of prematurity (AOP) in neonates and bibliometric analysis to identify to what degree citations vary or overlap between clinical guidelines. …

Adjunctive Therapies In The Management Of Tibial Stress Fractures: A Systematic Review Of The Literature, Hunter Smith, Joshua Rogers, Merrick Wetzler

Research Day

I. Introduction

Tibial stress fractures are common overuse injuries that are a source of pain, disability, and missed time from athletic activity. There are established protocols currently for return-to-play programs, but little consensus on the use of adjunctive modalities during the recovery period to reduce the recovery period. The purpose of this review is to summarize the results of randomized controlled literature evaluating the effectiveness of modalities to reduce time to healing in posteromedial tibial stress fractures.

II. Methods

A systematic search of PubMed, EMBASE, and Google Scholar was conducted between September 2022 and July 2023, following PRISMA guidelines. The …

The Role Of Ppars During Coxiella Burnetii Infection, Kaitlin C. O'Boyle, Maria Biancaniello, Minal Mulye

Research Day

Introduction

The obligate intracellular bacterium, Coxiella burnetii is transmitted to humans via inhalation of contaminated aerosols and subsequently causes Q fever. Coxiella persists in modified phagolysosomes termed Coxiella-containing vacuoles (CCV) within the alveolar macrophages it infects. Acutely, Q fever presents as a flu-like illness; however, chronic infection is often characterized by non-curable endocarditis. Q fever endocarditis can develop years after the initial infection, indicating the bacterium's ability to survive long-term. While the specific host cell pathways Coxiella targets to achieve this long-term survival remain unknown, our lab has demonstrated that Coxiella actively manipulates host lipid storage organelles known as …

Lasers And Topical Therapies For The Treatment Of Rosacea: A Systematic Review, Jane Mundadan, Margaret Chou, Maria J. Karim, Jessica Labadie, Robin Ashinoff

Research Day

Rosacea, a multifaceted skin condition characterized by facial redness, visible blood vessels, and acne-like bumps, lacks a definitive cure. Treatment options encompass oral medications, topical creams, and laser therapy. To assess the efficacy of combining laser procedures with topical treatments, a systematic review was conducted following PRISMA guidelines. The search, which included databases like PubMed and Embase, identified 496 studies, of which 8 met inclusion criteria.

These studies, involving a total of 200 patients aged between 33.8 to 51.1 years, utilized various combinations of laser therapy and topical agents. Most commonly used lasers included pulsed dye laser (PDL), potassium titanyl …

Effects Of Mitoquinone And Dexrazoxane On Doxorubicin’S Anti-Tumor Efficacy, Le Mai An, Aakash Belsare, James Huang, Juliet Melnik, Meagan Lyons, Lloyd Yan, Lindon H. Young, Robert J. Barsotti, Qian Chen

Research Day

Introduction

Doxorubicin (DOX) is a well-known chemotherapy drug for various cancers, including breast cancer. However, DOX-induced cardiotoxicity set a significant barrier limiting its clinical application. Dexrazoxane (Dex) is the only FDA-approved drug to protect the heart against DOX-associated damage. Nonetheless, it is still arguable if Dex induces secondary malignancy. Our lab previously showed that pretreating H9c2 myoblast with a mitochondrial-targeted antioxidant, mitoquinone (MitoQ), demonstrated significantly higher cell viability than cotreatment with DOX. Still, whether MitoQ pretreatment or cotreatment would potentiate DOX’s efficacy on cancer cells is unclear. Furthermore, it is intriguing to evaluate if MitoQ’s effects on DOX’s anti-tumor capacity …

Role Of Lipid Droplets And Prostaglandine2 In Coxiella Burnetii Intracellular Growth, Maria Biancaniello, Nell Guarino, Christabelle Ayensu-Asiedu, Steve Wooten, Minall Mulye

Research Day

Coxiella burnetii is an obligate intracellular bacterium that typically infects livestock. In humans, inhalation of Coxiella results in Q fever presented as atypical pneumonia, which may relapse after a prolonged latent period, leading to potentially fatal endocarditis. Our goal is to determine the mechanisms Coxiella employs to survive long-term in the host. While the bacterium initially infects alveolar macrophages, in endocarditis patients, Coxiella is found in foamy macrophages that are rich in neutral lipid storage organelles called lipid droplets (LDs). Our previous studies show that Coxiella manipulates host LD metabolism via the Type 4 Secretion System (T4SS), a major virulence …

Improving Iol Calculators’ Total Corneal Astigmatism Predictions With Deep Learning, Jason Fink, Mathieu Gauvin, Chirag Shah, Mark Cohen, Avi Wallerstein

Research Day

Precise intraocular lens (IOL) selection plays a critical role in optimizing surgical outcomes for patients undergoing IOL surgery. Traditionally, only the anterior corneal astigmatism (ACA) was considered during IOL selection. However, the posterior corneal astigmatism (PCA), also significantly impacts vision, though it is more challenging to measure directly. Advancements in deep learning offer a promising solution. By analyzing existing ACA measurements, deep learning algorithms can predict total corneal astigmatism (TCA) with high accuracy, effectively inferring PCA and enabling more precise IOL selection.

We employed a multivariate linear regression neural network (NN) and evaluated its performance through R-squared and root mean …

Increasing Motivation In Stem Education: A Self-Talk Classroom Intervention, Tiffany L. Copeland, Richard Allen, Sofia Pham, Kristin Gagnier

Research Day

INTRODUCTION: This study examines a social-emotional learning intervention that teaches positive self-talk to high school students from underrepresented minority groups in science, technology, engineering, and math (STEM). The setting of this study is a place-based program that immerses students in hands-on STEM activities while located in Philadelphia’s life science hub. Before taking a science assessment, students will learn to say self-talk statements such as “I will give my best effort” and “I can achieve a high score.”

METHODS: This mixed method quasi-experimental design compares pre- and post-program data using an ANOVA. Student science performance will be measured using a probe …

Sleep Quality Monitoring With Wearable Devices After Primary Total Knee Arthroplasty, Yash P. Chaudhry, Hunter Hayes, Efstratios Papadelis, Thomas Muzzonigro, Mark Lagreca, Kenneth Wojnowski, John Hobbs, Jackson Harvi, Andrew Star

Research Day

INTRODUCTION:

Patients undergoing total knee arthroplasty (TKA) are often subjected to immediate postsurgical pain and disruption of sleep. Recent studies have explored the role of postoperative sleep disruption using subjective assessments, however the literature on objective markers of sleep quality remain sparse. The aim of this pilot study was to assess objective measures of sleep quality in the immediate postoperative period following TKA.

METHODS:

Patients undergoing primary unilateral TKA at a level two medical center were enrolled in a prospective study in which they wore wearable sleep tracking devices (WHOOP, USA) for at least a week prior to surgery and …