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Articles 373741 - 373770 of 5167462
Full-Text Articles in Entire DC Network
Manga In Bookstores, Claire L. Curry
Manga In Bookstores, Claire L. Curry
Student Research Symposium
In recent years, manga has seen a surge in popularity. This research seeks to provide insights into the role of manga in U.S. bookstores and its implications for reader discovery. Through observations at bookstores in the Portland area, including Books with Pictures, Kinokuniya, Powell’s, and Barnes and Noble, it was examined how manga is presented to readers. Factors considered include manga’s physical placement in the store and surrounding sections as well as shelving methods and categorizations like genre labels, particularly for manhwa, manhua, and light novels. Display tables, end caps, and shelf talkers also demonstrate an unique way for bookstores …
Impact Of Mindfulness-Oriented Recovery Enhancement On Pain And Disability In Patients With Chronic Lumbosacral Radiculopathy: Results From An Rct, Danielle Zuzero
Impact Of Mindfulness-Oriented Recovery Enhancement On Pain And Disability In Patients With Chronic Lumbosacral Radiculopathy: Results From An Rct, Danielle Zuzero
Student Research Symposium
Lumbosacral Radiculopathy (LR), also known as sciatica, is a common type of radiating neurologic pain in the lower extremities with an estimated lifetime prevalence as high as 43%. The goal of this randomized control trial was to determine the impact of virtually delivered Mindfulness-Oriented Recovery Enhancement (MORE) on patients with LR. Participants were randomized to MORE sessions or treatment-as-usual (TAU) for 8 consecutive weeks, pain intensity was collected daily via email. At baseline and follow-up visits, participants completed questionnaires of disability, quality of life, depression, mindful interpretation of pain, and train mindfulness. Patients undergoing MORE sessions had greater improvement in …
Examining The Role Of Rgs2 In The Maintenance Of Diapause After Anoxic Stress In Embryos Of The Annual Killifish Austrofundulus Limnaeus, Patrick Clouser
Examining The Role Of Rgs2 In The Maintenance Of Diapause After Anoxic Stress In Embryos Of The Annual Killifish Austrofundulus Limnaeus, Patrick Clouser
Student Research Symposium
Austrofundulus limnaeus live in ephemeral ponds of Venezuela. They have evolved a unique life history that includes embryonic diapause, a period of developmental dormancy, metabolic arrest, and reduced protein synthesis. Diapausing embryos are resistant to environmental stress and survive months without oxygen (anoxia). A. limnaeus’ anoxia tolerance is an important survival mechanism as they can be buried in anoxic soil during development. Analysis of RNAseq data from diapausing A. limnaeus embryos show significant down-regulation of RGS2 transcripts in anoxic embryos. RGS2 regulates G-protein receptor signaling by inhibiting associated Ga-proteins and can inhibit protein synthesis. I hypothesis that …
Neuroscience Educational Interventions For Mental Health Management Within The Neurodiverse Population: A Working Model, Kadi Rae Smith, C.K. Miller, Bill Griesar, Jeff Leake
Neuroscience Educational Interventions For Mental Health Management Within The Neurodiverse Population: A Working Model, Kadi Rae Smith, C.K. Miller, Bill Griesar, Jeff Leake
Student Research Symposium
Sociological and environmental factors such as economic disparity and cultural marginalization hinder access to educational and medical resources and must be taken into account to ensure accurate diagnoses, effective self-regulation and mental health management for neurodiverse individuals, and offset disparities in access to healthcare and education. Arbitrary attachment of stigma to traits commonly associated with neurodivergence perpetuate neuro-myths1 that have dire consequences when internalized, informing individuals’ development and sense of self. Neuroscience outreach done by NW Noggin is an active model for engaging communities with limited resources and a greater need for services to offset economic disparity. Integrated arts programming …
Locating Vitamin D Receptors (Vdrs) In Annual Killifish, Austrofundulus Limnaeus, Rosalia N. Tanori, Amie L. Romney, Jason E. Podrabsky
Locating Vitamin D Receptors (Vdrs) In Annual Killifish, Austrofundulus Limnaeus, Rosalia N. Tanori, Amie L. Romney, Jason E. Podrabsky
Student Research Symposium
Austrofundulus limnaeus, a species of annual killifish found in unpredictable temporary habitats in South America, has a profound ability to survive long periods without water and oxygen. This tolerance is associated with the ability to enter metabolic dormancy associated with diapause. Entrance into diapause and tolerance of environmental stress is governed by an interplay of genetic and environmental factors. The vitamin D receptor (VDR) is among these factors and plays a crucial role in determining if an embryo will enter diapause or actively develop. My work aims to identify the genomic locations of VDR proteins in the A. limnaeus genome …
Impact Of Intersecting Vulnerabilities On Functional Outcome And Health-Related Quality Of Life After Traumatic Brain Injury: A Prospective Cohort Study, Rekesh Subedi, Tatiana Hoyos-Gomez, Luis Tinoco-Garcia, John Cervantes Cervantes
Impact Of Intersecting Vulnerabilities On Functional Outcome And Health-Related Quality Of Life After Traumatic Brain Injury: A Prospective Cohort Study, Rekesh Subedi, Tatiana Hoyos-Gomez, Luis Tinoco-Garcia, John Cervantes Cervantes
Student Research Symposium
Traumatic Brain Injury (TBI) is a critical public health issue that disproportionately affects select vulnerable populations, including race/ethnic minorities, low-income individuals, and those without health insurance. Despite high incidences of TBI and its considerable impact on morbidity and mortality, research is limited in addressing how the intersectionality of vulnerabilities contributes to outcomes post-TBI. This literature review aims to synthesize existing knowledge regarding Social determinants of health (SDH) on TBI outcomes, focusing on functional recovery and health-related quality of life (HRQOL). This study will use a prospective cohort research design where TBI patients at Oregon Health and Science University (OHSU) will …
Work And Psychological Recovery Experiences Of Asian American And Pacific Island Workers In Higher Education, Christine M. Beceril
Work And Psychological Recovery Experiences Of Asian American And Pacific Island Workers In Higher Education, Christine M. Beceril
Student Research Symposium
Individuals from Asian, Asian American, and Pacific Islander (AAPI) backgrounds constitute the largest and fastest-growing minority group in the U.S. job market - comprising 6.7% of the U.S. population and expected to reach 15% by 2065 (United States Census Bureau, 2022). Despite their rapid growth, there has been a scarcity of literature in industrial-organizational psychology, with limited research on how AAPI workers engage in psychological recovery after work. This is a critical, yet unexplored area as previous research on psychological recovery from work has been investigated with homogenous White samples. Additionally, AAPI workers play integral roles in the U.S. higher …
Analyzing Intensifying Storm Events Correlation To Landslide Frequency In Portland’S West Hills, Aurora Villa Juan
Analyzing Intensifying Storm Events Correlation To Landslide Frequency In Portland’S West Hills, Aurora Villa Juan
Student Research Symposium
As the Pacific Northwest climate changes, extreme weather, such as intensifying storms, and a shift in the type of precipitation experienced with warmer winters causing more precipitation to fall as rain instead of snow, may lead to an increased frequency of landslides. There have been several recent landslides in Portland, noticeable to the public, particularly in areas of high elevation such as Council Crest, which stands at 1,073 feet. Additionally, residents of neighboring homes have observed changes in the landscape, including those on private properties. To better safeguard both public and private property, comprehensive research and mitigation efforts are required. …
Annual Killifish: Eye Development And Retinal Cell Regeneration, Carmen Z. Rodriguez
Annual Killifish: Eye Development And Retinal Cell Regeneration, Carmen Z. Rodriguez
Student Research Symposium
Vertebrate eye development is highly conserved. Current models have allowed the understanding of gene expression patterns that support eye development, but lack the context of extreme environmental conditions that challenge these fundamental programs. Typical vertebrate life spans can be years, but annual killifish, Austrofundulus limnaeus, are able to complete their entire adult lifespan in only weeks. Thus, A. limnaeus is a strong model for age-related macular degeneration. A. limnaeus also experiences embryonic diapause; a period of developmental dormancy. Developing/diapausing embryos of A. limnaeus are resistant to environmental stresses such as hypoxia/anoxia that would cause irreparable damage to vital organs, such …
Selection During Reproduction In Mimulus Guttatus, Desmond C. Willson, Karla De Lima Berg, Mitch Cruzan
Selection During Reproduction In Mimulus Guttatus, Desmond C. Willson, Karla De Lima Berg, Mitch Cruzan
Student Research Symposium
A lack of genomic studies examining gametophytic selection and selective embryo abortion—which occur during the reproduction of angiosperms—leaves questions regarding the adaptive and evolutionary effects of these processes. Analyzing deviations from Mendelian segregation offers an avenue for identifying loci targeted by GS and SEA, and their contributions to purging of genetic load. However, other selective processes such as meiotic drive and cytonuclear interactions, as well as pollen and ovule abortion, can cause distortion. To distinguish the effects of GS and SEA from other causes of distortion, we will perform reciprocal crosses between highly homozygous and highly heterozygous individuals of Mimulus …
Self-Balancing Robot Leg, Ben Bolen
Self-Balancing Robot Leg, Ben Bolen
Student Research Symposium
Research in the Agile and Adaptive Robotics Lab involves the creation of biomimetic robots. To this end, we developed a self-balancing robot leg actuated with braided pneumatic actuators (BPAs)—a type of pneumatic artificial muscle. These BPAs, akin to human muscles, exhibit properties such as high strength-to-weight ratio and tunable passive stiffness. An Inertial Measurement Unit (IMU) was placed on top of the tibia for feedback and the tibia and foot were connected with a hinge joint. The orientation of the ankle joint was controlled with an Arduino microcontroller sending commands to the proportional pressure valves supplying the BPAs. Leg balance …
Hide & Cru-Seq: Investigating Potential Crucivirus Hosts With Fluorescently Labeled Protein, Marcell Devaune Richard, Nacho De La Higuera, Jono Abshier, Ken Stedman
Hide & Cru-Seq: Investigating Potential Crucivirus Hosts With Fluorescently Labeled Protein, Marcell Devaune Richard, Nacho De La Higuera, Jono Abshier, Ken Stedman
Student Research Symposium
Cruciviruses are DNA viruses that contain a capsid protein that shares striking similarities to capsid proteins from RNA viruses. Formerly known as “RNA-DNA hybrid viruses”, this novel type of viruses suggest gene exchange between unrelated RNA and DNA viruses. However, the hosts of cruciviruses remain unknown. To investigate this groundbreaking virus genome further, utilization of the predicted viral host recognition domain (P-domain) fused to a thermal green protein and a histidine tag, allows investigation of crucivirus hosts in environments where these viruses have been discovered. Using cruciviruses that have been found in soil samples on the PSU campus, along with …
Birkhoff Summation Of Irrational Rotation: A Surprising Result For The Golden Mean, Heather L. Moore
Birkhoff Summation Of Irrational Rotation: A Surprising Result For The Golden Mean, Heather L. Moore
Student Research Symposium
This research lies at the intersection of number theory and dynamical systems. We study the statistics of constant rotations by irrational numbers and investigate the relations between those statistics and the continued fraction approximates of a given irrational number.
This poster, which accompanies a written thesis, presents a surprising result that the difference in a certain sums of constant rotations by the golden mean approaches exactly 1/5. Specifically, we focus on the Birkhoff sums of these rotations, with the number of terms equal to squared Fibonacci numbers. The proof relies on the properties of continued fraction approximants, Vajda's identity and …
The Cost Of Healthy Eating, Diana Prychyna, Miriam R. Elman, Joy Kim, Karen F. Miller, Deonni P. Stolldorf, Sean P. Collins, Bory Kea
The Cost Of Healthy Eating, Diana Prychyna, Miriam R. Elman, Joy Kim, Karen F. Miller, Deonni P. Stolldorf, Sean P. Collins, Bory Kea
Student Research Symposium
Background
Annually in the US, 15-20% of 1,000,000 Emergency Department visits for acute Heart Failure (HF) result in discharge, and patients often experience adverse health outcomes. The study, Get With the Guidelines in Emergency Department Patients With Heart Failure, utilized ‘Self-Care Coaches’ who meet participants via telehealth calls to discuss self-care maintenance after discharge; and offer provisions of resources, including a cookbook.
During calls, we observed gaps in self-care for retired older adults, living alone, and receiving food stamps from the federal SNAP program, who expressed struggles with affording an HF-friendly diet.
Objective
To investigate if the target population in …
Neutron Time Of Flight Spectrometry As A Diagnostic Tool For Inertial Electrostatic Confinement Fusion Plasmas, Andrew H. Dempsey, Erik J. Sanchez
Neutron Time Of Flight Spectrometry As A Diagnostic Tool For Inertial Electrostatic Confinement Fusion Plasmas, Andrew H. Dempsey, Erik J. Sanchez
Student Research Symposium
Inertial electrostatic confinement (IEC) is a method for achieving fusion of light nuclei wherein ions are injected into a spherically symmetric system of concentric electrodes. When the innermost electrode is held at negative high voltage with respect to the outer electrode, ions injected into the reactor at cathode (ground) potential accelerate toward the anode where they may undergo collisions with sufficient energy to overcome Coulomb repulsion and achieve nuclear fusion. The most commonly used IEC fusion fuels are deuterium-deuterium (D-D) and deuterium-tritium (D-T). Both fuels undergo fusion reactions that result in production of fast neutrons with distinct energies. Neutron production …
Toward The Development Of An Ultra-Fast, Bright Photoelectron Emission Source Using Tip Enhancement, Pei-Hsiang Yen, Erik J. Sanchez
Toward The Development Of An Ultra-Fast, Bright Photoelectron Emission Source Using Tip Enhancement, Pei-Hsiang Yen, Erik J. Sanchez
Student Research Symposium
With the advancement of technology, people are pursuing even higher-resolution analysis results from metrology tools. When results are provided with temporal information, one can add a new dimension to the results. This research involves the development of a new temporal electron source by utilizing tip enhancement, which necessitates the creation of a novel type of emitter that emits electrons on a femtosecond (fs) time scale. Due to the nature of the electron’s mass, under the influence of an electric field they move quickly. To achieve our goal is the design of a resonant nano antenna (or known as a nantenna) …
Mutagenetic Analysis Of The Minor Capsid Protein Vp3 Of The Archaeal Fusellovirus Ssv1, Laura Costal Lagarde
Mutagenetic Analysis Of The Minor Capsid Protein Vp3 Of The Archaeal Fusellovirus Ssv1, Laura Costal Lagarde
Student Research Symposium
Viruses, while often associated with disease, are integral to life and play an important role in the microbiome. Despite their importance in medical research, archaeal viruses, particularly those found in extreme environments, are not widely understood. The Sulfolobus Spindle-Shaped Viruses (SSVs) of the Fuselloviridae family are unique among viruses in that they do not kill their host, the archaeon Sulfolobus Solfataricus in volcanic hot springs, but rather slow its growth, allowing for halo assay assessments.The study focuses on the type virus SSV1, which is predominantly composed of the Major and Minor capsid proteins vp1 and vp3, respectively. Previous study has …
Under The Influence Of Parents: A Longitudinal Study Of Children’S Walking, Kyu Ri Kim, Jennifer Dill
Under The Influence Of Parents: A Longitudinal Study Of Children’S Walking, Kyu Ri Kim, Jennifer Dill
Student Research Symposium
Researchers have studied children's active travel; however, they have mostly been cross-sectional studies dealing with commuting to school and parental attitudes. To find ways to promote children's active travel, this longitudinal study uses panel data (two time periods) to examine how parents' actual walking and safety perception correlated with children’s walking. Using data from 240 children aged 4-16 and their parents in Portland, Oregon, we estimated a cross-lagged panel model (CLPM) to analyze the continuous relationships. We found that parents with more positive attitudes toward their walking walked more, and their children also walked more in both periods. In addition, …
Gangism: An 'Elementary Form Of Religious Life', Robert Northman
Gangism: An 'Elementary Form Of Religious Life', Robert Northman
Student Research Symposium
This study is intended to examine the question: could gangs be a form of religion? The study will examine Steven Cureton's ethnographic case study of a street gang as found in his work titled Hoover Crips (2008), where I will then analyze the findings within the sociological framework of Emile Durkheim’s theory of religion as set forth in his classic book titled Elementary Forms of Religious Life (1912).
This exploration faces challenges as the terms “gang” and “religion” are both hotly contested, and discussions on each have largely occurred independently, leaving a significant gap for this research to address. This …
Relationship Between Trunk Cross-Sectional Area Growth And Water Stress In Garry Oaks (Q. Garryana): A Species Of Conservation Concern, John Cochrane
Relationship Between Trunk Cross-Sectional Area Growth And Water Stress In Garry Oaks (Q. Garryana): A Species Of Conservation Concern, John Cochrane
Student Research Symposium
In the Pacific Northwest, Quercus garryana (Garry oak trees) support over 627 native species. Garry oak natural habitat was originally maintained by indigenous practices but has been reduced to 5-10% of its range due to change in land management strategies. To support oak conservation, we need to understand heat and water affect the growth and physiology of this species. In this study, we created a fixed linear model of trunk cross-sectional growth with water stress (Ψ), photosynthetic water-use efficiency (δ13C), and leaf Carbon-Nitrogen ratio. We collected branch samples from the canopies of 47-64 mature Garry oaks in the …
Story Of Your Lazy Function’S Life: A Bidirectional Demand Semantics For Mechanized Cost Analysis Of Lazy Programs, Laura Israel, Nicholas Coltharp
Story Of Your Lazy Function’S Life: A Bidirectional Demand Semantics For Mechanized Cost Analysis Of Lazy Programs, Laura Israel, Nicholas Coltharp
Student Research Symposium
Lazy evaluation is a powerful tool that enables better compositionality and potentially better performance in functional programming, but it is challenging to analyze its computation cost. Existing works either require manually annotating sharing, or rely on separation logic to reason about heaps of mutable cells. In this paper, we propose a bidirectional demand semantics that allows for reasoning about the computation cost of lazy programs without relying on special program logics. To show the effectiveness of our approach, we apply the demand semantics to a variety of case studies including insertion sort, selection sort, Okasaki's banker's queue, and the push …
Promoting Student Engagement In Research In An Undergraduate Language-Development Course, Mitchell Kloer, Isabelle Trujillo, Teresa Roberts, Carolyn Quam
Promoting Student Engagement In Research In An Undergraduate Language-Development Course, Mitchell Kloer, Isabelle Trujillo, Teresa Roberts, Carolyn Quam
Student Research Symposium
This presentation will provide student perspectives on benefits of incorporating inclusive research activities within an undergraduate Speech and Hearing Sciences course. In Speech and Language Development in Children (SPHR 372U), instructor Quam incorporates a research project focusing on an issue of equity, inclusion, and social justice. One overarching goal is to reduce barriers of access to scientific research and increase engagement for college students, particularly those from historically underrepresented groups. The project is segmented into 3 steps that mirror literature review, critical analysis, and proposal. The project is collaborative, iterative throughout the term, and each step in the research process …
Stem Students And Faculty See Value In A Classroom Belonging Exercise, Kaisa S. Holt, Elizabeth A. Runkel-Baez
Stem Students And Faculty See Value In A Classroom Belonging Exercise, Kaisa S. Holt, Elizabeth A. Runkel-Baez
Student Research Symposium
Enhancing belonging in undergraduate STEM classrooms are pivotal for student success. This study examines a belonging exercise's implementation and impact in multiple STEM courses from 2017 to 2019. Faculty perspectives were gathered from a survey of 92 respondents, indicating a high level of perceived benefit (92%). Coded responses highlighted shared experiences and diversity mindset promotion. 30% explicitly mentioned benefits for both students and instructors. Additionally, 76% of faculty saw potential of belonging exercises in their own classrooms. It is important to promote using belonging interventions and also understand how STEM students perceive their value and utility. Three focus groups with …
Describing Shen & Shen Ming Via A Hybrid Quantum Computational Model, Alex M. Cullen, Johnny Lemau
Describing Shen & Shen Ming Via A Hybrid Quantum Computational Model, Alex M. Cullen, Johnny Lemau
Student Research Symposium
Definitions for Traditional Chinese Medicine (TCM) terminology within the context of quantum biology (QB) have recently been proposed. These definitions aim to elucidate concepts such as qi meridians in TCM. Our study presents a hypothesis that seeks to provide an operational definition for Spirit (Shen) and Bright Spirit (Shen Ming) in TCM via a scoping review. We propose that Shen represents physical, phenomenological proto-consciousness/consciousness in the forms of computation, such as singular particles/bits/qubits, computers, organisms, or computational strategies, whereas Shen Ming may refer to emergent, quasi-physical meta-proto-consciousness/consciousness formed by coherent relationships of multiple orchestrated/integrated units of computation; manifesting itself as …
The Influence Of Soil Composition On Stormwater Retention And Runoff In Green Roofs At Portland State, Manuel Edrozo, Lily Green, Mitchell Mcdonald, Nicholas Olmos
The Influence Of Soil Composition On Stormwater Retention And Runoff In Green Roofs At Portland State, Manuel Edrozo, Lily Green, Mitchell Mcdonald, Nicholas Olmos
Student Research Symposium
The purpose of this study is to determine what soil composition is best for green roofs at Portland State; we aim to compare the current soil to the original substrate, to measure which composition retains the most water, and which filters out the most pollutants in stormwater runoff. Five different soil compositions were tested — original, current, layered mixed, solid mixed, and potting soils — and 1,000mL of high and low intensity rainfall (in/hr) was simulated for each of the mixtures. Water was allowed to filter through the soils for a predetermined time (10min for a high application rate and …
Systematic Comparison Of Reservoir Computing Frameworks, Nihar S. Koppolu, Christof Teuscher
Systematic Comparison Of Reservoir Computing Frameworks, Nihar S. Koppolu, Christof Teuscher
Student Research Symposium
In this poster, we present a systematic evaluation and comparison of five Reservoir computing (RC) software simulation frameworks, namely reservoirpy, RcTorch, pyRCN, pytorch-esn, and ReservoirComputing.jl. RC is a specific machine learning approach that leverages fixed, nonlinear systems to map signals into higher dimensions. Its unique strength lies in training only the readout layer, which reduces the training complexity. RC excels in temporal signal processing and is also well suited for various physical implementations. The increasing interest in RC has led to the proliferation of various RC simulation frameworks. Our RC simulation framework evaluation focuses on a feature comparison, documentation quality, …
Evaluating Equitable Success In Literary Spaces: A Portland Book Festival Case Study, Tia-Theo I. Thompson
Evaluating Equitable Success In Literary Spaces: A Portland Book Festival Case Study, Tia-Theo I. Thompson
Student Research Symposium
In 2015, data expressing the lack of diversity in literary institutions was made publicly available, yet equitable change remains slow. How do literary institutions achieve and evaluate successes in equity? Do certain factors expedite this transition?
In a three year Diversity and Inclusion plan (2019-2022), the Portland nonprofit, Literary Arts, drastically altered their internal and external practices to accommodate/introduce BIPoC writers, presenters, and employees. The equitability of this plan is assessed at the Portland Book Festival (PBF), 2023. Data concerning the identities, placement, and publications of Writers and Presenters at PBF is analyzed within the context of the goals set …
Reed Research Reactor Neutron Beam Characterization And Analysis, Vee Bartko, Jerry Newhouse
Reed Research Reactor Neutron Beam Characterization And Analysis, Vee Bartko, Jerry Newhouse
Student Research Symposium
Using neutron activation analysis of 99% pure gold foils, the authors characterize the neutron dose and shape of the neutron beam at the Reed Research Reactor (RRR). The experimental procedure followed extensive modeling in Monte Carlo N-Particle (MCNP) and Tool for Particle Simulation (TOPAS) simulations, in which the beam was projected to be roughly collimated. The shape, defined in terms of neutron flux, was measured by placing the foils directly on top of the neutron beam cap at powers of 1, 5, and 10 kilowatts. The flux was then converted to neutron dose via the Nuclear Regulatory Commission's neutron fluence …
The Longitudinal Relationship Between Socioeconomic Status, Child Separation Anxiety Symptoms, And School Achievement In 1st Grade, Filip-Bogdan Serban-Dragan
The Longitudinal Relationship Between Socioeconomic Status, Child Separation Anxiety Symptoms, And School Achievement In 1st Grade, Filip-Bogdan Serban-Dragan
Student Research Symposium
This informative poster highlights a study examining the association between child separation anxiety disorder (SAD) and school achievement, considering socioeconomic status (SES) and perceived financial stress. Data came from the Early Growth and Development Study (EGDS). Data from the kindergarten (age 6) and 1st grade (age 7) assessments in the adoptive families (N=360 adoptive triads) were analyzed.
By controlling for parent’s income, financial stress, child’s gender and by measuring children at two time points (6 and 7 years), our study aims to identify the specific contribution of separation anxiety on academic achievement, enhancing our understanding of this …
Improved Genome Maintenance And Dna Replication In The Anoxia Tolerant Annual Killifish, Riley A. Roth-Carter
Improved Genome Maintenance And Dna Replication In The Anoxia Tolerant Annual Killifish, Riley A. Roth-Carter
Student Research Symposium
Timely and faithful replication of the genome is a requirement for cell survival and proliferation, with errors in this process leading to cancers and cell death. DNA replication during exposure to stressful conditions can lead to increased mutational burden, with collapsed replication forks causing mutations leading to cancers due to loss of repair capabilities during these exposures. Learning how stressful DNA replication takes places can lead to a better understanding of how resistant cancers survive similar conditions, like hypoxic tumor microenvironment, direct irradiation, and DNA damaging chemotherapeutics. Using an extremophile model, Austrofundulus limnaeus, which can survive these genotoxic stressors could …