Digital Commons Network^™

The Ire1Α/Xbp1 Pathway Sustains Cytokine Responses Of Group 3 Innate Lymphoid Cells In Inflammatory Bowel Disease, Siyan Cao, Jose L. Fachi, Kaiming Ma, Alina Ulezko Antonova, Qianli Wang, Zhangying Cai, Randal J. Kaufman, Matthew A. Ciorba, Parakkal Deepak, Marco Colonna

2020-Current year OA Pubs

Group 3 innate lymphoid cells (ILC3s) are key players in intestinal homeostasis. ER stress is linked to inflammatory bowel disease (IBD). Here, we used cell culture, mouse models, and human specimens to determine whether ER stress in ILC3s affects IBD pathophysiology. We show that mouse intestinal ILC3s exhibited a 24-hour rhythmic expression pattern of the master ER stress response regulator inositol-requiring kinase 1α/X-box-binding protein 1 (IRE1α/XBP1). Proinflammatory cytokine IL-23 selectively stimulated IRE1α/XBP1 in mouse ILC3s through mitochondrial ROS (mtROS). IRE1α/XBP1 was activated in ILC3s from mice exposed to experimental colitis and in inflamed human IBD specimens. Mice with Ire1α deletion …

Implications Of Varying Levels Of Social Support And Peer Involvement On The Success Of Baccalaureate Level Nursing Students, Jeana R. Wilcox

Dissertations

Nursing programs must be able to recruit and successfully train future nurses in a timely manner. However, some students, appearing adequately prepared in application materials, do not move successfully through baccalaureate nursing education, pass the licensing exam, and enter the nursing profession. Nursing students enter into a strictly prescribed curriculum leaving little time for traditional college environment socialization. Unveiling factors leading to greater persistence to degree attainment will ultimately lead to more nursing graduates needed to counter the current nursing shortage. One Midwestern program recently (2003-2004) lost 28% of incoming junior-level nursing students in the first two semesters (C. Horton, …

Front Matter

The Bridge

No abstract provided.

Red Boots And Lunch Bucket: Remembrances Of A Rural School, John Wolter Nielsen

The Bridge

No abstract provided.

Review: Anders Rasmussen, Civil War Settlers: Scandinavians, Citizenship, And American Empire, Svea Larson

The Bridge

No abstract provided.

Can Beggars Be Choosers? Adaptive Variation In Reproductive Investment Strategies Shapes Family Conflict And Cooperation In Wild Songbirds, Kelly Lynn O'Neil

Electronic Theses and Dissertations Archive

In this dissertation, I investigate the adaptive function of behavioral plasticity related to reproductive strategies in wild songbirds. Specifically, I uncover how various social, physiological, and environmental factors shape dynamics of conflict and cooperation between parents and offspring and among siblings. I performed 2 multi-year field experiments in which I cross-fostered nestlings between broods of wild songbirds, manipulating nestling size asymmetries (in Carolina wrens) and brood size (in prothonotary warblers) while including relevant controls. I observed nests during two developmental stages and used an intricate scoring protocol to quantify nestling begging dynamics, parental feeding decisions, and the distribution of food …

Shakespeare’S Economies Of Hospitality: Broken Comedies, Bad Hosts, And Troublesome Guests, John Henry Sauls

Electronic Theses and Dissertations Archive

Abstract Examining four Shakespeare plays for moments of hospitality and inhospitality, the question must be asked, “Is hosting and guesting necessary to maintain strong community?” In this exploration, hospitality is examined in four of Shakespeare’s plays, tracing its effects on the communities within those plays, showing that without hospitable performance, community falters and may eventually break apart. Such exploration of what goes well and not so well with hospitality offers a wealth of insight into cultural studies. Specific characters from these four plays are crucial to this study, as they provide concrete examples of human interactions gone awry and then …

Relationship Satisfaction For Significant Partners Of The Incarcerated: An Interpretative Phenomenological Analysis, Carrie Elizabeth Lund

Electronic Theses and Dissertations Archive

The United States incarcerates more individuals than any other country in the world (The Sentencing Project, 2023). Because of this, it is imperative that counseling professionals understand the lived experiences of those impacted by incarceration. Though research exists focusing on the effects of incarceration on children and families, there is still only a small body of research dedicated to understanding how incarceration impacts significant partners of the incarcerated. This study examined the lived experiences of eight significant partners of the incarcerated (SPIs) to better understand the ways in which incarceration impacted their romantic relationship satisfaction. Through the use of Interpretative …

Comparing Perceptions Of The Roles Of School Librarians Among Educators Using The Future Ready School Librarian Framework, Ellen Felicia Warden

Electronic Theses and Dissertations Archive

This non-experimental quantitative casual comparative survey study surveyed a sample (n=186) of public elementary (n=90), middle (n=69), and high school (n=57) school administrators (n=57), educators (n=62), and librarians (n=67) from 38 school districts across the state of Tennessee, regarding their perceptions of school librarians’ roles defined in the constructs of the Future Ready Schools – Librarian Framework. Results were analyzed via a one-way MANOVA and post hoc testing, and statistically significant differences in perceptions of the school librarian’s role were identified within the constructs of Use of Space and Time (p =<.001), Personalized Professional Learning (p=.025), Robust Infrastructure (p=.007), and Budget & Resources (p=.020). Statistical significance within these constructs is prevalent amongst comparison groups including the school librarian's role. Educators/teachers scored fulfillment perception higher than administrators and school librarians across all constructs. In contrast, school librarians scored fulfillment perception lower than other groups across all constructs, regardless of whether statistically significant results were found. Results implicate a need for changes to school librarian pre-service and future training to better prepare those entering and working the role to meet the expectations outlined within the Future Ready Schools Librarian Framework. Suggestions for future research and study limitations are also provided.

We’S Tied Boss: The Lived Experiences Of Black Professional Staff At A Historically White Institution During The Black Lives Matter Movement, Angela Smith Kuykendoll

Electronic Theses and Dissertations Archive

Although research has been conducted on the lived experiences of Black student affairs professionals and academic advisors at Historically White Institutions (HWIs), the literature is scant in its representation of the larger body of Black Professional Staff (BPS) and their experiences. BPS are undervalued and disregarded and are a vital part of the fabric of HWIs. Drawing on Critical Race Theory in Education, anti-Black racism, and plantation politics, the purpose of this critical race methodology study was to describe how Black Professional Staff experienced and navigated racism at an HWI in the context of the Black Lives Matter movement (BLM). …

Culturally Sustaining Pedagogy And Curricular Decision-Making In Elementary Art Education, Adeline Lynn White

Electronic Theses and Dissertations Archive

Contemporary art education fails to meet the needs of an increasingly diverse student population in K–12 schools. Although there is an increased understanding and awareness that culture must become essential to the art education of students, there is a gap in research on how art educators individually and collectively create culturally sustaining curricula and how it is implemented into the classroom and received by students. This holistic multiple-case study addresses the lack of culturally sustaining pedagogy (CSP) in the curricula used by art educators across the United States by examining how five elementary art educators designed opportunities to center student …

Perceptions Of Mattering Among General Education Teachers: Replication, Validation, And Extension Of The Fundamental Elements Of Mattering Scale For Teachers (Fems-T), Kailey B. Thornton

Electronic Theses and Dissertations Archive

This study aims to replicate, validate, and extend previous research on mattering in general education teachers. Specifically, this study sought to explore the psychometric properties of the Fundamental Elements of Mattering Scale for Teachers (FEMS-T; Wilfong, 2021). Participants completed demographic questions as well as questions related to their feelings of mattering as a teacher (N = 343). The study confirmed the factor structure of a streamlined 24-item FEMS-T, which exhibited better fit than the original 40 items identified by Wilfong (2021). The FEMS-T also demonstrated internal reliability and convergent validity with the Workplace Mattering Scale (WMS; Jung & Heppner, 2017). …

Studying Ketocarotenoid Metabolism In Cell Culture, Amir Hosein Sanjari Nia

Electronic Theses and Dissertations Archive

This study examines the conversion of carotenoids to ketocarotenoids, essential for bright plumage in birds, a trait crucial in sexual selection. We used DF-1 avian cells genetically engineered to express BDH1L, CYP2J19, and TTC39B, key enzymes in this conversion. The genetic modifications and enzyme activity were verified via PCR genotyping and RT-qPCR. These cells were treated with yellow carotenoids (zeaxanthin, β-carotene, lutein) and their conversion to red ketocarotenoids (astaxanthin, canthaxanthin, alpha-doradexanthin) was analyzed using High- Performance Liquid Chromatography (HPLC). The study also assessed the impact of antioxidant treatments and mitochondrial uncouplers on this process. Results indicated that the inclusion of …

Three Essays In Stock Price Crash Risk And Institutional Trading, Hung Dong Cao

Electronic Theses and Dissertations Archive

Despite a longstanding debate over the pros and cons of imposing legal liability on corporate directors and officers, there is limited research on how managerial litigation affects a firm’s future stock price crash risk. Essay 1 examines how the change in Nevada corporate law in 2001, which lowers the legal liability of corporate managers of Nevada-incorporated firms, affects the likelihood of future stock price crashes. We find that such a legal change leads to a decrease in stock price crash risk, and the effect is more pronounced for small, young, and weakly governed firms. Further analysis indicates that the decrease …

Official' Obliteration. Text And Image Destruction In Pre-Amarna Eighteenth Dynasty Theban Tombs, Margaret Deane

Electronic Theses and Dissertations Archive

This dissertation examines the phenomenon of memory sanction erasures against high official in pre-Amarna Eighteenth Dynasty Theban tombs. Memory sanctions are defined as the intentional erasure of the owners’ names, titles, and images on the decorated surfaces of their monuments. Over the course of the Eighteenth Dynasty, from the reign of Hatshepsut through the early years of Amenhotep IV, at least 21 officials fell victim to memory sanction erasures as attested from their decorated tomb chapels preserved in the Theban necropolis. The first goal of this dissertation is to systematically record each erasure currently present in the 21 tombs with …

Methods For The Analysis Of Diffusible Signaling Factors For The Determination Of Elution Activity, Structural Stability And Biological Activity, Brian Hoffman

Electronic Theses and Dissertations Archive

Biofilms pose a threat to public health. The National Institutes of Health estimate that biofilms are linked to 65-80% of hospital-related infections. Biofilms are a complex network of bacterial cells contained within an extracellular matrix and are 10-1000 times more resistant to common antibiotic treatments. Bacteria within a biofilm utilize a form of intercellular communication known as quorum sensing to regulate many cellular functions including the secretion of the extracellular matrix and dispersal of planktonic cells. Compounds known as diffusible signaling factors (DSF) regulate the formation/degradation of the extracellular matrix. One family of DSF consist of medium chain fatty acid …

Impact Of Parent Reported Adverse Experiences And Other Family Stressors On Child Development And Home Visitation Participation Among Immigrant Families, Fithi Andom

Brown School Graduate Student Theses and Dissertations

This dissertation examines variations in early childhood developmental and socioemotional health as well as level of participation in home visitation among recent immigrant families according to reports of adverse experiences (including poverty, intimate partner violence (IPV), and prior history of child protective services (CPS) involvement), maternal depression, and parent–child relationship measures. The period of early childhood is dependent on positive parenting to support optimum development, but parenting may be particularly sensitive to the detrimental influences of adverse experiences. Less is known about how the relationship between parenting, adverse experiences, and child development may differ for immigrant families. Home visitation has …

Creating Sustainable School And Home Gardens: Welcoming Pollinators, Kaitlin Cambell, Rita Hagevik, Kathy Cabe Trundle

All Current Publications

This fact sheet is part of a series about creating sustainable school and home gardens. It focuses on welcoming pollinators to the garden by providing a safe and effective habitat, and lists recommended plantings and resources.

Soil Organic Matter Components And Characteristics Of Forest Soil In Spruce And Sycamore Plantations In The Temperate Region, Samuel Obeng Apori, Michelle Giltrap, Julie Dunne, Furong Tian Nanolab Research Centre, Focas Research Institute

Articles

The stability of soil organic matter (SOM) that governs soil organic carbon (SOC) storage depends on its characteristics and components, but little is known about how tree species in forest ecosystems affect SOM components and characteristics. In this study, we used FTIR spectroscopy to investigate plantations of two ecologically and economically significant tree species—namely, spruce (Picea spp.) and sycamore (Acer pseudoplatanus)—in order to determine how the different litter inputs and root-microbe interactions of these two plantations affect the functional groups, components, and characteristics of their SOM. Soil samples were taken from the topsoil (0–10 cm) and subsoil (10–20 cm). In …

Beyond The Task: Developing A Tool To Measure Workplace Characteristics That Affect Cognitive Load And Learning, Sarah Blissett, Sebastian Rodriguez, Atif Qasim, Patricia O'Sullivan

Department of Medicine Faculty Papers

PURPOSE: Educators lack tools to measure the workplace characteristics that learners perceive to affect learning. Without a tool that encompasses the social, organizational, and physical components of workplace learning environments (WLEs), it is challenging to identify and improve problematic workplace characteristics. Using echocardiography WLE, this study developed a tool to measure workplace characteristics that cardiology fellows perceive to affect learning.

METHOD: The Workplace-Cognitive Load Tool (W-CLT) was developed, which encompasses 17 items to measure workplace characteristics that could affect perceived cognitive load and learning. Exploratory factor analysis was used to identify the most parsimonious structure. A total of 646 cardiology …

Addressing Or Reinforcing Injustice? Artificial Amnion And Placenta Technology, Loss-Sensitive Care And Racial Inequities In Preterm Birth, Sophie L Schott, Faith Fletcher, Alice Story, April Adams

Center for Medical Ethics and Health Policy Staff Publications

No abstract provided.

Emotional First Aid Kit Design, Wenxi Qi

Theses

In contemporary society, the shift towards holistic well-being has highlighted the critical importance of emotional health in maintaining overall quality of life. Research indicates that emotional health issues now pose a greater threat to individual well-being and productivity than physical ailments. Despite this, there exists a significant gap in awareness and emphasis between physical and emotional health across various sectors, contributing significantly to the prevalence of mental health issues. This research paper introduces the "Emotional First Aid Kit," a novel design concept aimed at addressing emotional distress in everyday scenarios similar to conventional first aid kits managing physical injuries. The …

A Systematic Review To Determine The Effect Of Strategies To Sustain Chronic Disease Prevention Interventions In Clinical And Community Settings: Study Protocol, Edward Riley-Gibson, Byron J Powell, Et Al.

2020-Current year OA Pubs

BACKGROUND: The primary purpose of this review is to synthesise the effect of strategies aiming to sustain the implementation of evidenced-based interventions (EBIs) targeting key health behaviours associated with chronic disease (i.e. physical inactivity, poor diet, harmful alcohol use, and tobacco smoking) in clinical and community settings. The field of implementation science is bereft of an evidence base of effective sustainment strategies, and as such, this review will provide important evidence to advance the field of sustainability research.

METHODS: This systematic review protocol is reported in accordance with the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) checklist. Methods …

Renal Artery Stenosis: Evaluation, Workup, Imaging, And Intervention, Praveen Sankrithi, Paul Grebe

Aurora GME

No abstract provided.

A Common Polymorphism In The Intelectin-1 Gene Influences Mucus Plugging In Severe Asthma, Jamie L Everman, Kaharu Sumino, David S. Gierada, Et Al.

2020-Current year OA Pubs

By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical significance of intelectin-1 (ITLN-1) in the development of pathologic airway mucus in asthma. Through analyses of human airway epithelial cells we find that ITLN1 gene expression is highly induced by interleukin-13 (IL-13) in a subset of metaplastic MUC5AC

Imaging Features Of Primary Intracranial Sarcoma With Dicer1 Mutation: A Multicenter Case Series, Rami W Eldaya, Richard J Fagan, Samir A Dagher, Angshumoy Roy, Sonika Dahyia, Gregory N Fuller, Max Wintermark, Matthew S Parsons, Thierry A G M Huisman

Faculty, Staff and Student Publications

Primary intracranial sarcoma, DICER1-mutant, is a rare, recently described entity in the fifth edition of the WHO Classification of CNS Tumors. Given the entity's rarity and recent description, imaging data on primary intracranial sarcoma, DICER1-mutant, remains scarce. In this multicenter case series, we present detailed multimodality imaging features of primary intracranial sarcoma, DICER1-mutant, with emphasis on the appearance of the entity on MR imaging. In total, 8 patients were included. In all 8 patients, the lesion demonstrated blood products on T1WI. In 7 patients, susceptibility-weighted imaging was obtained and demonstrated blood products. Primary intracranial sarcoma, DICER1-mutant, …

Downregulation Of Mirlet7 Mirna Family Promotes Tc17 Differentiation And Emphysema Via De-Repression Of Rorγt, Phillip A Erice, Xinyan Huang, Matthew J Seasock, Matthew J Robertson, Hui-Ying Tung, Melissa A Perez-Negron, Shivani L Lotlikar, David B Corry, Farrah Kheradmand, Antony Rodriguez

Faculty, Staff and Students Publications

Environmental air irritants including nanosized carbon black (nCB) can drive systemic inflammation, promoting chronic obstructive pulmonary disease (COPD) and emphysema development. The let-7 microRNA (Mirlet7 miRNA) family is associated with IL-17-driven T cell inflammation, a canonical signature of lung inflammation. Recent evidence suggests the Mirlet7 family is downregulated in patients with COPD, however, whether this repression conveys a functional consequence on emphysema pathology has not been elucidated. Here, we show that overall expression of the Mirlet7 clusters, Mirlet7b/Mirlet7c2 and Mirlet7a1/Mirlet7f1/Mirlet7d, are reduced in the lungs and T cells of smokers with emphysema as well as in mice with …

Techniques For Determining The Location Of Networking Equipment Operated In Mobile Communication Networks, Anshul Tanwar

Defensive Publications Series

Proposed herein is a novel technique to determine the location of networking equipment (e.g., routers, switches, etc.) used in mobile communication networks, such as cellular Fourth Generation (4G) and/or Fifth Generation (5G) communication networks. Once the location of a particular piece of networking equipment is known, this location can then be exported or collected by a central controller, which can utilize the location for various purposes, such as performing further validation of the location of the equipment to confirm that the equipment is being used at a location for which its use is allowed by the equipment manufacturer.

Collaborative Printing For Ground Printers, Hp Inc

Defensive Publications Series

This disclosure relates to the field of ground printers (Fig. 1). These units are used to draws lines on the floor, by moving while printing what architects and engineers project in their computer and transform digital plans into real floorplan, accelerating constructions building and speeding up their job.

A method is disclosed to create a collaborative printing mode to reduce the printing time and ensure job printing completion. Several ground printers will share the same job, print different areas and update their progress so the control system knows the areas that are already printed.

A central processor will …

The Legality Of Liberation: Exploring The Right To Organized Armed Resistance Against The U.S. State By Afro-Descendants Under International Human Rights Law, Laura Molik

Northwestern Law Journal des Refusés

No abstract provided.