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Climate Change In Mississippi: A Journalistic Exploration Of Education And Activism, Kala Nance May 2024

Climate Change In Mississippi: A Journalistic Exploration Of Education And Activism, Kala Nance

Honors Theses

Climate Change in Mississippi: A Journalistic Exploration of Education and Activism takes an investigative, journalistic approach toward climate change in Mississippi. Specifically, how education and awareness have a direct impact on Mississippi industries, people and legislation. The project explored the level of acknowledgement of climate change across the state, and how certain individuals used advocacy to encourage education about climate change to raise awareness of the severity of the situation. This project includes interviews with university professors and researchers, non-profit organizations, educational groups and working individuals in some of Mississippi’s largest areas of employment. Additionally, this project draws on research …


"Ole Miss": A Case For The Name's Removal And Steps Toward Implementation, William Henderson May 2024

"Ole Miss": A Case For The Name's Removal And Steps Toward Implementation, William Henderson

Honors Theses

The purpose of this project is to provide one justification of why the University of Mississippi should cease its usage of its nickname, “Ole Miss,” and provide insight into what the next steps of the University should be. “Ole Miss” is a term that was installed with the intention of romanticizing the social order that the system of slavery provided in the Antebellum South. The attitudes toward plantation society that the name perpetuates pose several forms of harm to members of the University’s community. Institutions of higher learning maintain a special relationship with their students, which presents a strong obligation …


Manipulative, Dark, And Unethical Design Practices In Ui & Ux Design, Ryan Edward Brown May 2024

Manipulative, Dark, And Unethical Design Practices In Ui & Ux Design, Ryan Edward Brown

Honors Theses

This thesis examines the pervasive and detrimental effects of manipulative user interface and user experience design (UI/UX) practices on individuals and society. Focusing on three critical areas – accessibility, dark patterns, and polarization – the study employs a mixed-methods approach, combining findings from a comprehensive literature review, an analysis of specific design patterns and methods, and a survey of user experiences.
The literature review covers topics such as the importance of accessibility in design education, the prevalence of dark patterns in mobile and desktop sites, the role of personalization algorithms in shaping user experiences, and the formation of echo chambers …


Utilizing Journaling To Develop A Personalized And Efficient Musical Practice Regimen, Erin Kilpatrick May 2024

Utilizing Journaling To Develop A Personalized And Efficient Musical Practice Regimen, Erin Kilpatrick

Honors Theses

Musicians universally agree that practicing consistently is vital to improvement. However, a lot of young musicians do not understand how to practice effectively. There are many factors that influence practice time, focus, and overall learning. For the purpose of this research, I will define “efficient practicing” as any practice that increases development as a player and encourages the player to continue in pursuit of learning music. This encompasses physical aspects like ligature, reed, mouthpiece, and the horn itself, as well as more broad musicianship fundamentals such as developing a characteristic tone, building technique, and learning how to phrase appropriately, must …


Lasting Impact: Analyzing The Relationship Between Colonialism And Proxy War Onset, Sydney Rehm May 2024

Lasting Impact: Analyzing The Relationship Between Colonialism And Proxy War Onset, Sydney Rehm

Honors Theses

Proxy wars are a very specific subset of war that have increased in frequency. Researchers have studied why proxy wars occur, but there are less studies specifically on to what extent, if any, colonialism has on the onset of proxy wars. To fill this gap, I write a historical analysis of past proxy wars—specifically the Vietnam War (1955-1975), Lebanese Civil War (1975-1990), and Yemeni Civil War (2014-present)—to examine the effects of colonialism. Furthermore, I utilize my case studies to assess my argument’s limitations. I also utilize statistical analysis to determine the probability of proxy war if a country has a …


Get It Out Of My Head: The Psychological Effects Of Music In Strategic Advertising Practices, Brady Jonah Wood May 2024

Get It Out Of My Head: The Psychological Effects Of Music In Strategic Advertising Practices, Brady Jonah Wood

Honors Theses

For generations, music has served as a powerful marketing tool. When radio reigned supreme as the go-to source of household entertainment, savvy advertisers employed any means necessary to capture the listener's attention. Even today, music remains a powerful force in shaping culture, driving, and reinforcing consumer behavior.

This study aims to explore how brands leverage music in their advertisements to enhance consumers' recall of their products. By utilizing music as a marketing tool, advertisers can effectively ingrain their products in consumers' minds. Selected advertisements are examined to determine how the effect of advertising jingles can create a consistent and memorable …


Are We Ready: Envisioning An Inclusive Higher Education Program For Individuals With Intellectual And Developmental Disabilities At The University Of Mississippi, Bailey Beaird May 2024

Are We Ready: Envisioning An Inclusive Higher Education Program For Individuals With Intellectual And Developmental Disabilities At The University Of Mississippi, Bailey Beaird

Honors Theses

An inclusive higher education program (IHEP) exists for individuals with intellectual and developmental disabilities (I/DDs) to foster academic success, employment equipping, interpersonal skill development, and active participation and value validation in the community. Establishing an IHEP can benefit current university students, faculty, and staff, and individuals with I/DDs and their families to create a more informed, inclusive environment. The University of Mississippi (UM) does not currently have an IHEP. Therefore, my advocacy initiative seeks to provide an opportunity for individuals with I/DDs to receive a college education and experience at UM. For two and a half years, I independently researched …


Inotuzumab Ozogamicin For The Treatment Of Adult Acute Lymphoblastic Leukemia: Past Progress, Current Research And Future Directions, Nicholas J Short, Elias Jabbour, Nitin Jain, Hagop Kantarjian May 2024

Inotuzumab Ozogamicin For The Treatment Of Adult Acute Lymphoblastic Leukemia: Past Progress, Current Research And Future Directions, Nicholas J Short, Elias Jabbour, Nitin Jain, Hagop Kantarjian

Faculty, Staff and Student Publications

Inotuzumab ozogamicin (INO) is an anti-CD22 antibody-drug conjugate that was first evaluated in B-cell lymphomas but was subsequently shown to be highly effective in acute lymphoblastic leukemia (ALL). INO improved response rates and survival in a randomized study in adults with relapsed/refractory B-cell ALL, leading to its regulatory approval in the United States in 2017. While the formal approval for INO is as monotherapy in relapsed/refractory ALL, subsequent studies with INO administered in combination with chemotherapy and/or blinatumomab both in the frontline and salvage settings have yielded promising results. In this review, we discuss the clinical development of INO in …


Going Beyond The Margins: Photographs By Ming Smith, Isis A. Serna May 2024

Going Beyond The Margins: Photographs By Ming Smith, Isis A. Serna

Art & Art History ETDs

Ming Smith is a photographer who has been creating images since the early 1970s and trained with the artist collective Kamoinge Workshop. Throughout most of her career, Smith has been marginalized by art historians, critics, and museum curators. Since the early 2000s, Smith has only been included in museum exhibitions highlighting African-American female artists from 1960 to the present. Before this surge of interest in her work, the art world ignored and silenced her. However, Smith’s creative process allowed her to see and experience going beyond the struggle by being consistent in her strategy to do what she wanted on …


The Effects Of Light Cycle Disruption On The Reactive Oxygen Species Production In Zebrafish, Talia Sanders May 2024

The Effects Of Light Cycle Disruption On The Reactive Oxygen Species Production In Zebrafish, Talia Sanders

Honors College Theses

It has been proven that maintaining homeostasis is linked to regulation of circadian rhythms and the light cycles associated with them. Through investigation of zebrafish mitochondria subject to stress via unpredictable light cycle exposure, we previously studied the level of GSK3β protein as it relates to the health of the brain. The data has shown that when a brain undergoes stress, it results in the increased activation of GSK3β which leads to disruptions in circadian rhythm, inflammation, and cell death. Moreso, this overexpression results in reduced ATP production and lowered Complex 1 activity in the mitochondria. However, GSK3β activation is …


Evaluation Of Error Sources In Dynamic Multiple-Input Multiple-Output (Mimo) Tests, Odey Yousef May 2024

Evaluation Of Error Sources In Dynamic Multiple-Input Multiple-Output (Mimo) Tests, Odey Yousef

Civil Engineering ETDs

Dynamic testing of systems is used to characterize the relationship between inputs and outputs using frequency response functions (FRFs). Multiple input and multiple output (MIMO) techniques are crucial for realistic representation. In MIMO tests, environmental conditions are replicated by inverting the FRF matrix for input estimation. Steps include system identification, FRF inversion, input estimation, and input application. Each of these steps are nontrivial and require careful attention. Error sources manifest as error between desired and experimental outputs. Significant efforts to minimize this error exist, yet literature lacks a formal understanding of their origins. This research focuses on 3 of these …


Depositional Facies Analysis Of The Cotton Valley Group Sandstones Of The Blackburn Field, Northern Louisiana Using Well Logs And Cores; Implications For Carbon Sequestration, Frederick Owusu May 2024

Depositional Facies Analysis Of The Cotton Valley Group Sandstones Of The Blackburn Field, Northern Louisiana Using Well Logs And Cores; Implications For Carbon Sequestration, Frederick Owusu

Electronic Theses and Dissertations

The Cotton Valley Group (CVG) consists of tight sandstones with heterogeneous reservoir properties due to variations in depositional environments and diagenesis, spanning across eastern Texas through the Florida panhandle. It has served as a hydrocarbon target since the 1940s, and with recent technological advances, there is renewed exploration of the tight reservoirs within the group. Across northern Louisiana, the CVG has moderate to good reservoir properties, whereas those south extending westward across the Sabine uplift into east Texas decrease in porosity and permeability. With reservoir depletion coupled with its relatively simple mineralogy, these sandstone units may serve as good, localized …


Exploring The Mandelbrot Set, James Shirley May 2024

Exploring The Mandelbrot Set, James Shirley

Electronic Theses and Dissertations

The Mandelbrot set is a mathematical mystery. Finding its home somewhere be-
tween holomorphic dynamics and complex analysis, the Mandelbrot set showcases
its usefulness in fields across the many realms of math—ranging from physics to nu-
merical methods and even biology. While typically defined in terms of its bounded
sequences, this thesis intends to illuminate the Mandelbrot set as a type of param-
eterization of connectivity itself, specifically that of complex-valued rational maps
of the form z → z² + c. This fully illustrated guide to the Mandelbrot set merges
the worlds of intuition and theory with a series of …


Regulation Of Cerebral Blood Flow Boosts Precise Brain Targeting Of Vinpocetine-Derived Ionizable-Lipidoid Nanoparticles, Xufei Bian, Ling Yang, Dingxi Jiang, Adam J Grippin, Yifan Ma, Shuang Wu, Linchong Wu, Xiaoyou Wang, Zhongjie Tang, Kaicheng Tang, Weidong Pan, Shiyan Dong, Betty Y S Kim, Wen Jiang, Zhaogang Yang, Chong Li May 2024

Regulation Of Cerebral Blood Flow Boosts Precise Brain Targeting Of Vinpocetine-Derived Ionizable-Lipidoid Nanoparticles, Xufei Bian, Ling Yang, Dingxi Jiang, Adam J Grippin, Yifan Ma, Shuang Wu, Linchong Wu, Xiaoyou Wang, Zhongjie Tang, Kaicheng Tang, Weidong Pan, Shiyan Dong, Betty Y S Kim, Wen Jiang, Zhaogang Yang, Chong Li

Faculty, Staff and Student Publications

Despite advances in active drug targeting for blood-brain barrier penetration, two key challenges persist: first, attachment of a targeting ligand to the drug or drug carrier does not enhance its brain biodistribution; and second, many brain diseases are intricately linked to microcirculation disorders that significantly impede drug accumulation within brain lesions even after they cross the barrier. Inspired by the neuroprotective properties of vinpocetine, which regulates cerebral blood flow, we propose a molecular library design centered on this class of cyclic tertiary amine compounds and develop a self-enhanced brain-targeted nucleic acid delivery system. Our findings reveal that: (i) vinpocetine-derived ionizable-lipidoid …


La Teoría De Los Arquetipos De Northrop Frye, Invierno: Ironía Y Sátira, Marcos O. Cabobianco May 2024

La Teoría De Los Arquetipos De Northrop Frye, Invierno: Ironía Y Sátira, Marcos O. Cabobianco

STEM for Success Resources

En esta presentación Marcos Cabobianco habla de la estructura narrativa de la desintegración irónica y su relación con el sacrificio


Indigenous Leadership: Leading The Journey So Others Follow, Ophelia M. Sanchez May 2024

Indigenous Leadership: Leading The Journey So Others Follow, Ophelia M. Sanchez

Teacher Education, Educational Leadership & Policy ETDs

Leadership is a ceremony. All leaders need to envision a sense of purpose as the journey begins. I examined interactions among attitudes, perceptions, and decisions through Indigenous female leaders’ personally identified leadership styles and how to integrate Indigeneity for positive change in their environment. The purpose of this study was to help guide school leaders through initiating educational change and to give courage to Indigenous female leaders to continue to lead or step into leadership. In exploring these interactions, I examined Indigenous women’s leadership experiences, values, and beliefs. This study provided valuable insight to women of all ages, educators, school …


Vitamin C: Is It Relevant Or Obsolete In The Modern Era?, Suruchi Ramanujan, Kadakkal Radhakrishnan May 2024

Vitamin C: Is It Relevant Or Obsolete In The Modern Era?, Suruchi Ramanujan, Kadakkal Radhakrishnan

Student Scholarship

Purpose: In this review, we discuss the historic background of vitamin C, vitamin C’s physiology, its dietary sources, and how deficiency can manifest. We also discuss modern studies investigating the role of Vitamin C in immunity, in cardiovascular disease, and in chronic conditions. Summary: In the body, vitamin C acts as an essential cofactor in several enzymatic reactions including, but not limited to, neurotransmitter synthesis, hormone amidation, collagen synthesis, hypoxic transcription factor modification, and epigenetic modifications. Scurvy, caused by severe vitamin C deficiency, is an infamous disease recorded in historical documents, with patients presenting with joint ache, bleeding gums, depression, …


Securing The Skies: Safety-Constrained Decentralized Multi-Uav Coordination With Deep Reinforcement Learning, Jean-Elie Pierre May 2024

Securing The Skies: Safety-Constrained Decentralized Multi-Uav Coordination With Deep Reinforcement Learning, Jean-Elie Pierre

Electrical and Computer Engineering ETDs

In the dynamic landscape of autonomous aerial systems, the integration of uncrewed aerial vehicles (UAVs) has sparked a paradigm shift, offering unprecedented opportunities and challenges in collaborative decision-making and navigation. This thesis explores the application of multi-agent reinforcement learning (MARL) for the planning and coordination of UAVs in complex environments.

The first part of this thesis provides an introduction to single-agent reinforcement learning and MARL. We provide examples of the use of MARL for countering uncrewed aerial systems (C-UAS). We formulate the Counter-UAS problem as a multiagent partially observable Markov decision process (MAPOMDP), and we propose Multi-AGent partial observable deep …


Implementation Of Virtual Reality Motivated Physical Activity Via Omnidirectional Treadmill In A Supported Living Facility For Older Adults: A Mixed-Methods Evaluation.: Virtual Reality To Motivate Physical Activity For Older Adults, Hannah Louise Bradwell, Leonie Cooper, Rory Baxter, Simone Tomaz, Katie Jane Edwards, Anna C Whittaker, Ray B. Jones May 2024

Implementation Of Virtual Reality Motivated Physical Activity Via Omnidirectional Treadmill In A Supported Living Facility For Older Adults: A Mixed-Methods Evaluation.: Virtual Reality To Motivate Physical Activity For Older Adults, Hannah Louise Bradwell, Leonie Cooper, Rory Baxter, Simone Tomaz, Katie Jane Edwards, Anna C Whittaker, Ray B. Jones

School of Nursing and Midwifery

Virtual reality (VR) can support healthy ageing, but few devices have been trialed with frail older adults to increase physical activity. We conducted a preliminary mixed-methods implementation evaluation of an omnidirectional VR treadmill and a static VR experience with seven older adults over a six-week period in a supported living facility. Frequency of use and pre-post physical functioning measures were collected, mainly to establish technology suitability based on person characteristics. Diary entries following technology use, resident focus group and staff interview revealed technology acceptance and perceived potential for increasing physical activity, health and wellbeing through accessing virtual environments, which motivated …


Teaching Double Bass Through Lost Traditions Of The 18th Century, Tina Battaglia May 2024

Teaching Double Bass Through Lost Traditions Of The 18th Century, Tina Battaglia

Senior Honors Projects, 2020-current

Through learning how to improvise entire compositions from unfigured bass using stock classical schemata, this paper seeks to bring awareness to the technical and musical benefits of translating 18th century compositional keyboard etudes called partimenti into double bass etudes.


Dataset Of Weekly Intra-Treatment Diffusion Weighted Imaging In Head And Neck Cancer Patients Treated With Mr-Linac, Dina M El-Habashy, Kareem A Wahid, Renjie He, Brigid Mcdonald, Samuel J Mulder, Yao Ding, Travis Salzillo, Stephen Y Lai, John Christodouleas, Alex Dresner, Jihong Wang, Mohamed A Naser, Clifton D Fuller, Abdallah Sherif Radwan Mohamed, Joint Head And Neck Radiation Therapy-Mri Development Cooperative May 2024

Dataset Of Weekly Intra-Treatment Diffusion Weighted Imaging In Head And Neck Cancer Patients Treated With Mr-Linac, Dina M El-Habashy, Kareem A Wahid, Renjie He, Brigid Mcdonald, Samuel J Mulder, Yao Ding, Travis Salzillo, Stephen Y Lai, John Christodouleas, Alex Dresner, Jihong Wang, Mohamed A Naser, Clifton D Fuller, Abdallah Sherif Radwan Mohamed, Joint Head And Neck Radiation Therapy-Mri Development Cooperative

Faculty, Staff and Student Publications

Radiation therapy (RT) is a crucial treatment for head and neck squamous cell carcinoma (HNSCC); however, it can have adverse effects on patients' long-term function and quality of life. Biomarkers that can predict tumor response to RT are being explored to personalize treatment and improve outcomes. While tissue and blood biomarkers have limitations, imaging biomarkers derived from magnetic resonance imaging (MRI) offer detailed information. The integration of MRI and a linear accelerator in the MR-Linac system allows for MR-guided radiation therapy (MRgRT), offering precise visualization and treatment delivery. This data descriptor offers a valuable repository for weekly intra-treatment diffusion-weighted imaging …


The Impact Of Dual Credit On Student Success: A Mixed Methods Study At A Texas University, Jennifer D. Coker Goddard May 2024

The Impact Of Dual Credit On Student Success: A Mixed Methods Study At A Texas University, Jennifer D. Coker Goddard

Electronic Theses and Dissertations

In 2015, the number of students enrolled in dual credit coursework in United States (U.S.) schools had reached over 1.4 million, a 68% increase over the previous few years (Field, 2021). By this year, 88% of U.S. high schools offered dual credit programs, and 34% of students enrolled in dual credit coursework, indicating a steady growth in dual credit programming (Rhine, 2022). Furthermore, 27% of public high school students in Texas earned credit for dual credit coursework (Villarreal, 2017). Despite significant growth in dual credit coursework offerings, limited knowledge of the effectiveness of these programs in preparing students for post-secondary …


Fayetteville State University Spring Commencement May 11, 2024, Fayetteville State University May 2024

Fayetteville State University Spring Commencement May 11, 2024, Fayetteville State University

Graduation Exhibit

Program for Fayetteville State University Spring Commencement  May 11, 2024

Keynote Speaker: Jacqie Williams-Parker- CIAA Commissioner


Design And Analysis Of Passive Correlator Radio-Frequency Identification Tagging, Albert Kilgore May 2024

Design And Analysis Of Passive Correlator Radio-Frequency Identification Tagging, Albert Kilgore

McKelvey School of Engineering Graduate Student Theses & Dissertations

Radio Frequency Identification (RFID) is a technology used in many industries to locate and track assets. Passive RFID tags are popular because they are inexpensive and flexible, but they have limited accuracy. My thesis aims to improve the accuracy of passive RFID tags by investigating two solutions: (a) Using orthogonal RFID configuration and exploiting phase information available to an RFID reader, in addition to the received signal strength indicator (RSSI) metric; and (b) Designing a novel voltage multiplier-based correlator circuit that can be integrated directly onto the tag. To further reduce power consumption and silicon area, we propose an architecture …


A Framework For Filtering Irrelevant Notams, Roudha Abdulrahman May 2024

A Framework For Filtering Irrelevant Notams, Roudha Abdulrahman

Theses

The Notice to Airmen (NOTAM) system is essential for aviation safety, giving critical information on risks and operating limitations. However, the volume and complexity of NOTAM data complicate interpretation, which could compromise safety and efficiency. This study tries to address these issues by creating a predictive algorithm for analyzing NOTAM data and predicting whether to keep or remove them. The methodology combines effective machine learning algorithms to reveal insights that improve safety and operational efficiency. Using a dataset of NOTAM entries, multiple prediction algorithms are tested to forecast possible problems and enable proactive risk management. The study's findings help to …


Investigation Of Residual Mineral Content Of Bauxite Stockpiles, Saline Mining District, Arkansas, U.S.A., Melanie L. Ertons May 2024

Investigation Of Residual Mineral Content Of Bauxite Stockpiles, Saline Mining District, Arkansas, U.S.A., Melanie L. Ertons

Electronic Theses and Dissertations

The former mining town of Bauxite is in the Saline County Mining District, in central Arkansas. Bauxite is located approximately 40 km (25 mi) southwest of Little Rock just east of Benton, Arkansas. This area contains extensive deposits of bauxite ore and nepheline syenite previously mined by Aluminum Company of America using open pit and subsurface mining techniques. This study incorporates five bauxite stockpiles (SP1, Clay, SP2, SP3, SP4) with varying amounts of alumina content situated on approximately 10 acres of land within an area of the former mine recognized as Section 20. Over the past several years, there has …


A Narrative Inquiry Into Contingent Music Faculty Experiences, Herbert Midgley May 2024

A Narrative Inquiry Into Contingent Music Faculty Experiences, Herbert Midgley

Electronic Theses and Dissertations

The increasing reliance on short-term or contingent faculty reflects a shift away from tenure-track positions. Tenure-track faculty reduction is significant in academic disciplines such as music. This qualitative narrative inquiry study explored the professional experiences of contingent music faculty through semi-structured interviews. Narrative inquiry allows for individual participant voice in which this study examined participant relationships with faculty colleagues, employment experiences at higher education institutions, and working conditions. Implications of this study include new ways of understanding support structures from colleagues and institutions for contingent music faculty members, deeper perspective about the current state of teaching at their universities, and …


The Greenbeard Gene Tgrb1 Regulates Altruism And Cheating In Dictyostelium Discoideum, Mariko Katoh-Kurasawa, Peter Lehmann, Gad Shaulsky May 2024

The Greenbeard Gene Tgrb1 Regulates Altruism And Cheating In Dictyostelium Discoideum, Mariko Katoh-Kurasawa, Peter Lehmann, Gad Shaulsky

Faculty, Staff and Students Publications

Greenbeard genetic elements encode rare perceptible signals, signal recognition ability, and altruism towards others that display the same signal. Putative greenbeards have been described in various organisms but direct evidence for all the properties in one system is scarce. The tgrB1-tgrC1 allorecognition system of Dictyostelium discoideum encodes two polymorphic membrane proteins which protect cells from chimerism-associated perils. During development, TgrC1 functions as a ligand-signal and TgrB1 as its receptor, but evidence for altruism has been indirect. Here, we show that mixing wild-type and activated tgrB1 cells increases wild-type spore production and relegates the mutants to the altruistic stalk, whereas mixing …


Occupational Tasks Associated With Shoulder Pain And Upper Extremity Disability: A Cross-Sectional Study In The Johnston County Osteoarthritis Project, Elizabeth L Yanik, Carolina Alvarez, Rebecca J Cleveland, Amanda E Nelson, Yvonne M Golightly May 2024

Occupational Tasks Associated With Shoulder Pain And Upper Extremity Disability: A Cross-Sectional Study In The Johnston County Osteoarthritis Project, Elizabeth L Yanik, Carolina Alvarez, Rebecca J Cleveland, Amanda E Nelson, Yvonne M Golightly

2020-Current year OA Pubs

BACKGROUND: Shoulder pain is a leading cause of disability. Occupations requiring high upper extremity demands may put workers at greater risk of shoulder injury and resulting pain. We examined associations of occupation with shoulder pain and upper extremity disability in the Johnston County Osteoarthritis Project.

METHODS: Work industry and occupational tasks for the longest job held were collected from participants. At follow-up ranging from 4-10 years later, participants were asked about shoulder symptoms (pain, aching, or stiffness occurring most days of 1 month in the last year) and given a 9-item, modified Disabilities Arm Shoulder and Hand (DASH) questionnaire to …


Genome-Wide Epistatic Network Analyses Of Semantic Fluency In Older Adults, Qihua Tan, Weilong Li, Marianne Nygaard, Ping An, Mary Feitosa, Mary K Wojczynski, Joseph Zmuda, Konstantin Arbeev, Svetlana Ukraintseva, Anatoliy Yashin, Kaare Christensen, Jonas Mengel-From May 2024

Genome-Wide Epistatic Network Analyses Of Semantic Fluency In Older Adults, Qihua Tan, Weilong Li, Marianne Nygaard, Ping An, Mary Feitosa, Mary K Wojczynski, Joseph Zmuda, Konstantin Arbeev, Svetlana Ukraintseva, Anatoliy Yashin, Kaare Christensen, Jonas Mengel-From

2020-Current year OA Pubs

Semantic fluency impairment has been attributed to a wide range of neurocognitive and psychiatric conditions, especially in the older population. Moderate heritability estimates on semantic fluency were obtained from both twin and family-based studies suggesting genetic contributions to the observed variation across individuals. Currently, effort in identifying the genetic variants underlying the heritability estimates for this complex trait remains scarce. Using the semantic fluency scale and genome-wide SNP genotype data from the Long Life Family Study (LLFS), we performed a genome-wide association study (GWAS) and epistasis network analysis on semantic fluency in 2289 individuals aged over 60 years from the …