Digital Commons Network^™

The Macrophage Landscape Across The Lifespan Of A Human Cardiac Allograft, Xiao Li, Diwakar Turaga, Rich G Li, Chang-Ru Tsai, Julianna N Quinn, Yi Zhao, Ruby Wilson, Katherine Carlson, Jun Wang, Joseph A Spinner, Edward J Hickey, Iki Adachi, James F Martin

Faculty, Staff and Student Publications

Background: Much of our knowledge of organ rejection after transplantation is derived from rodent models.

Methods: We used single-nucleus RNA sequencing to investigate the inflammatory myocardial microenvironment in human pediatric cardiac allografts at different stages after transplantation. We distinguished donor- from recipient-derived cells using naturally occurring genetic variants embedded in single-nucleus RNA sequencing data.

Results: Donor-derived tissue resident macrophages, which accompany the allograft into the recipient, are lost over time after transplantation. In contrast, monocyte-derived macrophages from the recipient populate the heart within days after transplantation and form 2 macrophage populations: recipient MP1 and recipient MP2. Recipient MP2s have cell …

An Unexpected Path For Malat1 In Neurons: Trafficking Out Of The Nucleus For Translation, Bradley W Wright, Jeremy E Wilusz

Faculty, Staff and Students Publications

The Malat1 (metastasis-associated lung adenocarcinoma transcript 1) long noncoding RNA is highly and broadly expressed in mammalian tissues, accumulating in the nucleus where it modulates expression and pre-mRNA processing of many protein-coding genes. In this issue of Genes & Development, Xiao and colleagues (doi:10.1101/gad.351557.124) report that a significant fraction of Malat1 transcripts in cultured mouse neurons are surprisingly exported from the nucleus. These transcripts are packaged with Staufen proteins in RNA granules and traffic down the lengths of neurites. They then can be released in a stimulus-dependent manner to be locally translated into a microprotein that alters neuronal gene …

Feasibility, Acceptability And Preliminary Effect Of A Community-Led Hiv Self-Testing Model Among Adolescent Girls And Young Women In Rural Northern Uganda: A Quasi-Experimental Study Protocol, Ronald Olum, Elvin H Geng, Freddy E Kitutu, Philippa M Musoke

2020-Current year OA Pubs

BACKGROUND: Adolescent girls and young women (AGYW) in sub-Saharan Africa face a disproportionately higher HIV/AIDS burden despite the global decline in incidence. Existing interventions often fail to adequately address their unique social, economic, and cultural challenges, limiting access to essential HIV/AIDS services, including HIV testing. Emerging evidence indicates that HIV self-testing, a user-friendly and confidential method, enhances HIV diagnosis and linkage to care by targeting these barriers. This study aims to assess the feasibility, acceptability, and preliminary impact of a peer-delivered, community-health worker (CHW)-facilitated HIV self-testing intervention for AGYW in Northern Uganda.

METHODS: This mixed-methods quasi-experimental implementation science study will …

Graded Decisions In The Human Brain, Tao Xie, Markus Adamek, Hohyun Cho, Matthew A Adamo, Anthony L Ritaccio, Jon T Willie, Peter Brunner, Jan Kubanek

2020-Current year OA Pubs

Decision-makers objectively commit to a definitive choice, yet at the subjective level, human decisions appear to be associated with a degree of uncertainty. Whether decisions are definitive (i.e., concluding in all-or-none choices), or whether the underlying representations are graded, remains unclear. To answer this question, we recorded intracranial neural signals directly from the brain while human subjects made perceptual decisions. The recordings revealed that broadband gamma activity reflecting each individual's decision-making process, ramped up gradually while being graded by the accumulated decision evidence. Crucially, this grading effect persisted throughout the decision process without ever reaching a definite bound at the …

Molecular Insights Into The Prototypical Single-Stranded Dna-Binding Protein From E. Coli, Nina J Bonde, Alexander G Kozlov, Michael M Cox, Timothy M Lohman, James L Keck

2020-Current year OA Pubs

The SSB protein of

On The Heating Of The Slow Solar Wind By Imbalanced Alfvén-Wave Turbulence From 0.06 To 1 Au: Parker Solar Probe And Solar Orbiter Observations, Sofiane Bourouaine, Jean C. Perez, Benjamin D G Chandran, Vamsee K. Jagarlamudi, Nour E. Raouafi, Jasper S. Halekas

Faculty Publications

In this work we analyze plasma and magnetic field data provided by the Parker Solar Probe and Solar Orbiter missions to investigate the radial evolution of the heating of Alfvénic slow wind by imbalanced Alfvén-wave (AW) turbulent fluctuations from 0.06 to 1 au. in our analysis we focus on slow solar-wind intervals with highly imbalanced and incompressible turbulence (i.e., magnetic compressibility C B = δ B/B ≤ 0.25, plasma compressibility C n = δ n/n ≤ 0.25, and normalized cross helicity σ c ≥ 0.65). First, we estimate the AW turbulent dissipation rate from the wave energy equation and find …

Response To Comments On The Tolerance To Clostridioides Difficile Spores To Sodium Hypochlorite Disinfection, Humaira Ahmed, Lovleen Tina Joshi

Peninsula Dental School

No abstract provided.

Full-Body Stretches, Gabriela Murza

All Current Publications

This one-page guide provides stretching ideas for the whole body. A QR code is also included to access a video that you can follow as you move through the different stretching activities.

Comprehensive Proteogenomic Characterization Of Rare Kidney Tumors, Ginny Xiaohe Li, Yize Li, Nataly Naser Al Deen, Feng Chen, Wagma Caravan, Andrew Houston, Siqi Chen, Li Ding, Et Al.

2020-Current year OA Pubs

Non-clear cell renal cell carcinomas (non-ccRCCs) encompass diverse malignant and benign tumors. Refinement of differential diagnosis biomarkers, markers for early prognosis of aggressive disease, and therapeutic targets to complement immunotherapy are current clinical needs. Multi-omics analyses of 48 non-ccRCCs compared with 103 ccRCCs reveal proteogenomic, phosphorylation, glycosylation, and metabolic aberrations in RCC subtypes. RCCs with high genome instability display overexpression of IGF2BP3 and PYCR1. Integration of single-cell and bulk transcriptome data predicts diverse cell-of-origin and clarifies RCC subtype-specific proteogenomic signatures. Expression of biomarkers MAPRE3, ADGRF5, and GPNMB differentiates renal oncocytoma from chromophobe RCC, and PIGR and SOSTDC1 distinguish papillary RCC …

Ciliary Tip Actin Dynamics Regulate Photoreceptor Outer Segment Integrity, Roly Megaw, Abigail Moye, Zhixian Zhang, Fay Newton, Fraser Mcphie, Laura C Murphy, Lisa Mckie, Feng He, Melissa K Jungnickel, Alex Von Kriegsheim, Peter A Tennant, Chloe Brotherton, Christine Gurniak, Alecia K Gross, Laura M Machesky, Theodore G Wensel, Pleasantine Mill

Faculty, Staff and Students Publications

As signalling organelles, cilia regulate their G protein-coupled receptor content by ectocytosis, a process requiring localised actin dynamics to alter membrane shape. Photoreceptor outer segments comprise an expanse of folded membranes (discs) at the tip of highly-specialised connecting cilia, into which photosensitive GPCRs are concentrated. Discs are shed and remade daily. Defects in this process, due to mutations, cause retinitis pigmentosa (RP). Whilst fundamental for vision, the mechanism of photoreceptor disc generation is poorly understood. Here, we show membrane deformation required for disc genesis is driven by dynamic actin changes in a process akin to ectocytosis. We show RPGR, a …

Artificial Intelligence (Ai) Generated Templates, N/A

Defensive Publications Series

The technology described herein is directed to artificial intelligence (AI) model-generated templates that can be used by content creators to generate at least a portion of digital content, such as advertisements. The AI-generated templates allow for content creators to generate templates that meet a threshold digital content criteria without having to manually write formulas to generate the digital content. The AI model can generate templates based on feed data, natural language inputs related to the digital content to be generated, and/or existing group templates. The output of the model includes template formulas that can be used to generate portions of …

Composable Microled Monitors, Hp Inc

Defensive Publications Series

With advancements in microLED display technology, it will soon be possible to make microLED-based screens in smaller sizes. Just as for their larger LED-based cousins, it should be possible to eliminate bezels, and in doing so allow large displays to be constructed from smaller tiles. In such systems there is a need to simplify setup for consumers and to make the configuration obvious to the user and available to the operating system. In addition, it may be necessary to disguise the joints between adjacent panels.

Accordingly, we propose a desktop computer monitor constructed by end-users from a set of Lego-like …

Full Issue: Volume 20, Number 1 - Spring 2024

Jefferson Surgical Solutions

A publication for friends and colleagues of Jefferson’s Department of Surgery

In This Issue

Cover Story Nader Hanna, MD, Named Inaugural Chief of the Division of Surgical Oncology - Page 1

Overview Our Jefferson Bicentennial: Thank You Dr. George McClellan - Page 2

Leadership Jefferson Health Names Enterprise Surgeon Leaders - Page 2

Clinical Integration New Center Offers State-of-the-Art Treatment for Chest Wall Disorders - Page 3

Please Welcome New Faculty - Page 3

Those Who Give Paying it Forward: Grateful Alumna Funds Surgical Pilot Grants - Page 4

News in Brief News in Brief - Page 4

News In Brief

Jefferson Surgical Solutions

Talar Tatarian, MD, served as Program Chair for The Women’s Leadership in Surgery Society (WLISS) annual meeting in Washington, D.C. last September. She was joined by three of our residents – Drs. Fari Fall, Sneha Alaparthi, and Isheeta Madeka.

Keshava Rajagopal, MD, PhD, was awarded a $125,000 grant from the W.W. Smith Charitable Trust for the project entitled “Allosteric modulation of beta2-adrenergic receptor to enhance cardiac function.”

Michelle Hughes, MSN, RN, CBRN, was recently certified as one of the first certified burn nurses by the American Burn Association (ABA). Hughes is the Burn Nurse Coordinator at the …

Paying It Forward: Grateful Alumna Funds Surgical Pilot Grants

Jefferson Surgical Solutions

Knowing Jefferson’s reputation for training successful surgeons, Shaheen Timmapuri, MD, MBA, was thrilled to match in surgery at Jefferson Medical College, now Sidney Kimmel Medical College, in 2000. Although it’s been nearly 20 years since she completed her residency, she still vividly recalls the quality of her experience.

Dr. Timmapuri notes that she not only received an excellent clinical education, but also learned valuable lessons in compassion, respect, teamwork and integrity. She also remembers a specific incident that helped her achieve her goal of becoming a pediatric surgeon.

“This was before residency included a mandatory year of research,” she explains. …

Judicial Antagonism To Executive Power: An Analysis Of Emerging Doctrinal Trends In Federal Courts, Kyle James

Political Analysis

Kyle James is a senior Political Science major at Seton Hall University and the Executive Editor of Political Analysis. Following graduation, he will be attending Wake Forest University School of Law as a JD candidate. He aspires to practice securities, antitrust, and regulatory law in Washington D.C. or North Carolina. His research interests include federal courts, civil procedure, and administrative law. This paper was conceived in response to recent judicial decisions that have upended traditional understandings of the administrative state.

Unitary Executive Theory, Audrey Espinosa

Political Analysis

Audrey Espinosa is a third year Political Science major in the 3+3 Law Program at Seton Hall University. She plans to pursue a career as a lawyer and is currently interested in researching constitutional and ideological politics. Her paper on the Unitary Executive Theory was inspired by the Constitutional Law class that she took in the Fall 2023 semester with Professor Pallitto. The topic was briefly covered in class texts and discussions, and she wanted to further explore the theory and argue against its principles with references to books, academic journals, and Supreme Court cases. She plans to pursue a …

Absolute Presidency: History And Framework Of American Executive Government, Garrett Mershimer

Political Analysis

Garrett is a senior seeking a Bachelor of Arts Degree in Political Science. His research interests include American Politics but also cover topics such as church-state relations, the subject of his senior thesis. When writing this paper in the first half of his junior year, he was inspired to explore the true authority and discretionary powers of the President within the executive branch.

Putin's Pivot: Understanding The Evolution Of Russia's Anti-Western Stance, Nicole Fernandez

Political Analysis

Nicole Fernandez is a first-generation student who majors in political science and minors in criminal justice. She aspires to become an attorney who practices immigration law. During her senior thesis class, the topic of Russian-American relations immediately captured her interest, as she watched a documentary detailing Putin's evolving interactions with the last five American presidents the summer before. Witnessing the dynamic shifts in these relationships over time piqued her curiosity about Russia's increasingly anti-Western stance. This interest was further fueled by ongoing geopolitical conflicts. Although her research interests lie in Latin American relations with the US, delving into an unchartered …

What Does ‘Sex’ Mean To You? The Rainbow Bench Gives Their Opinion. A Discussion On Textualism By Amicus Curiae Briefs Written By Nonprofits In Bostock V. Clayton County, Isabella Rojas

Political Analysis

Isabella Rojas is a recent Magna Cum Laude graduate of Seton Hall University Class of 2023, holding a B.A. in Political Science. She is an incoming J.D. Candidate at Rutgers Law School. Ms. Rojas hopes to pursue a career in legal academia while continuing research in LGBTQ+ scholarship. The objective of her research was to critically analyze the influence of the nonprofit sector on the interpretation of legal text. Her thesis was inspired by her interest in judicial interpretation and the philosophical framework underlying court opinions.

Secularization And Women's Liberation: An Analysis Of Women's Freedoms In The Modern Era, Anna Humphrey

Political Analysis

Anna Humphrey, Seton Hall University class of 2024, is a senior Political Science major with minors in Spanish and Environmental Studies. Anna is a member of the Communications Committee for Adelante Latino/a Student Organization and is a Statistics Tutor at the Math Learning Lab on campus. After graduation, she hopes to work in legislative analysis or lobbying. She is primarily interested in environmental and immigration policy. Her thesis paper was inspired by both Professor Jeffrey Togman's research on the rise of atheism and her passion for women's rights.

Like, Follow, And Subscribe: The Potential Effect Of Social Media On The 2024 Elections, Nyada Bryant

Political Analysis

Nyada Bryant is a political science major with a minor in sociology who will be graduating in the spring of 2024. After graduation, she intends on going to graduate school and getting her masters in diplomacy as she would like to seek a career in that field of study or international affairs. For her senior thesis class, she had to focus on the 2024 election and decided to examine tactics that politicians were utilizing on social media. Thus, this paper delves into political communication, reliability and longevity in the digital world.

Table Of Contents, N/A N/A

Political Analysis

No abstract provided.

New Faculty

Jefferson Surgical Solutions

Abdelsalam Elshaikh, MD, has joined the Division of Vascular Medicine. Dr. Elshaikh is a graduate of the University of Gezira Faculty of Medicine in Sudan. He then went on to complete an internal medicine internship at Beaumont Health in Dearborn, MI, and his internal medicine residency at St. Luke’s University Health Network in Bethlehem, PA. Following residency, he worked as a hospitalist for two years before completing a vascular medicine fellowship at the University Hospitals of Cleveland Medical Center. He cares for patients at the Jefferson Vascular Center in Center City.

Rakesh M. Suri, MD, DPhil, has joined …

New Center Offers State-Of-The-Art Treatment For Chest Wall Disorders

Jefferson Surgical Solutions

Patients with chest wall conditions and injuries can now obtain comprehensive care through the Jefferson Center for Chest Wall Disorders.

Led by Olugbenga Okusanya, MD, Associate Professor of Surgery, the Center offers innovative procedures for Pectus Excavatum, Thoracic Outlet Syndrome (TOS), Slipping Rib Syndrome, as well as rib and sternum fractures and several other non-cancerous chest wall conditions.

“The center formalizes our team-based approach to getting the best outcomes for patients,” Dr. Okusanya explains.

Dr. Okusanya routinely collaborates closely with his partners in thoracic surgery: Drs. Nathaniel Evans, Tyler Grenda, and John Jacobs. The team also includes trauma surgeons Drs. …

Jefferson Health Names Enterprise Surgeon Leaders, Charles J. Yeo

Jefferson Surgical Solutions

The past nine years have brought a series of mergers and acquisitions that dramatically expanded the physical footprint and clinical resources of Jefferson Health. What started as an academic medical center in Center City Philadelphia has grown to a robust network of 17 hospitals and physician practices serving patients in five Delaware Valley counties, and beyond.

Jefferson Health’s growth has fueled new opportunities to improve patient care, clinical research and medical education. Achieving those goals requires thoughtful integration of people, processes and technology—with strong leadership to guide the journey.

In January, Jefferson Health formally named an Enterprise Surgeon Leader for …

Our Jefferson Bicentennial: Thank You Dr. George Mcclellan, Charles J. Yeo

Jefferson Surgical Solutions

1824 was a leap year. Lord Byron died in Missolonghi, Greece. Beethoven’s Ninth Symphony premiered in Vienna. And a surgeon, Dr. George McClellan, five years out of medical school himself, had the vision and aspiration to make Philadelphia the only U.S. city with two medical schools. McClellan was a Yale graduate (chemistry, 1815) attended Penn Med (’19) and due to the politics of the time and his ties to the Presbyterian church, chose to affiliate this new Philadelphia medical school via a charter with Jefferson College – a prior log cabin school located 312 miles away – in the sleepy …

Nader Hanna, Md, Named Inaugural Chief Of The Division Of Surgical Oncology

Jefferson Surgical Solutions

In January, Jefferson Health and the Sidney Kimmel Medical College, in collaboration with the Sidney Kimmel Cancer Center, named Nader Hanna, MD, as the inaugural chief of the Division of Surgical Oncology and Vice Chair for Cancer Services in the Department of Surgery. Dr. Hanna is also serving as the Enterprise Surgeon Leader for Surgical Oncology (see article on page 2).

The newly created division shares faculty members and advanced practice clinicians with other divisions covering complex general surgical oncology and breast surgery, as well as melanoma, gastrointestinal, colorectal, peritoneal and endocrine surgical oncology specialties, among others.

In his new …

Aluminum Extendable Battery Tray For Commercial Vehicle Battery Enclosure, Salahuddin Mohammad

Defensive Publications Series

Extendable battery enclosures may enable a commercial truck to not only swap the batteries/enclosures, but also to add more battery enclosures based on customer requirements and wheelbase limitations. Using an aluminum extendable battery structure, a commercial truck may house more battery capacity for higher range with adding minimal weight to the overall truck weight when compared to using steel battery structures. This may be relevant to payload and gross vehicle weight rating limitations applicable to commercial trucks.

Visa Ai Agnostic Intelligent Routing (Vaair), Renato Marques Dos Santos, Vinicius Amorim Ferreria De Castro

Defensive Publications Series

The present disclosure relates to an AI-based technique to optimize international transactions/global money movements process. The technique recites generating a query message based on the transaction information received from the sender device. The technique further recites transmitting the query message to the plurality of transaction channels in order to receive the response from the plurality of transaction channels based on the request. Finally, the technique recites identifying the optimal transaction channels among the plurality of transaction channels based on the response from the plurality of transaction channels and transmitting the optimal transaction channels to the sender device.