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On The Two-Fold Fuzzy N-Refined Neutrosophic Rings For 2≤N≤3, Abdallah Shihadeh, Khaled Ahmad Mohammad Matarneh, Raed Hatamleh, Mowafaq Omar Al-Qadri, Abdallah Al-Husban Jun 2024

On The Two-Fold Fuzzy N-Refined Neutrosophic Rings For 2≤N≤3, Abdallah Shihadeh, Khaled Ahmad Mohammad Matarneh, Raed Hatamleh, Mowafaq Omar Al-Qadri, Abdallah Al-Husban

Neutrosophic Sets and Systems

The objective of this paper is to study the two-fold fuzzy algebra based on n-refined neutrosophic rings for some different special values of n, where we study some of the special elements in the case of two-fold 2-refined neutrosophic ring and 3-refined neutrosophic rings such as units, idempotents, and nilpotent elements. Also, we present the concept of two-fold ring homomorphism with its elementary properties.


On The Special Gamma Function Over The Complex Two-Fold Algebras, Nabil Khuder Salman Jun 2024

On The Special Gamma Function Over The Complex Two-Fold Algebras, Nabil Khuder Salman

Neutrosophic Sets and Systems

The concept of special functions plays an important role in mathematical analysis and physics as well. In this paper, we study some different types of the special Gamma function defined on the two-fold fuzzy complex field, where we combine the classical Gamma function with the two-fold fuzzy algebra defined on complex numbers. On the other hand, many elementary properties of this new special function will be determined in terms of theorems and proofs.


The Limits Of 2- Refined Neutrosophic, Yaser Ahmad Alhasan, Mohamed Elghazali Ali Mohieldin Mohamed, Raja Abdullah Abdulfatah Jun 2024

The Limits Of 2- Refined Neutrosophic, Yaser Ahmad Alhasan, Mohamed Elghazali Ali Mohieldin Mohamed, Raja Abdullah Abdulfatah

Neutrosophic Sets and Systems

this paper aims to present the limits of 2- refined neutrosophic, where we studied the of the neutrosophic factorization method and the neutrosophic rationalization method of the limits of 2- refined neutrosophic, we verified the results of these methods using the L'Hôpital's rule. Also We introduced some special limits and 2- refined neutrosophic trigonometric limits. In addition to clarifying this by solving appropriate numerical examples


Combined Topsis Technique For Magdm Based On The Distance Measures And Critic Under Single-Valued Neutrosophic Sets And Applications To Quality Evaluation Of Whole Process Engineering Consulting Service Modes, Xia Wang, Yingxia Hou, Jing Peng, Jiekun Hu, Yue Li, Qiang Cai, Guiwu Wei Jun 2024

Combined Topsis Technique For Magdm Based On The Distance Measures And Critic Under Single-Valued Neutrosophic Sets And Applications To Quality Evaluation Of Whole Process Engineering Consulting Service Modes, Xia Wang, Yingxia Hou, Jing Peng, Jiekun Hu, Yue Li, Qiang Cai, Guiwu Wei

Neutrosophic Sets and Systems

According to survey data released by the National Bureau of Statistics, from 2011 to 2022, the total output value of China's construction industry showed an increasing trend year by year. From 2018 to 2021, infrastructure investment has always maintained a positive growth, indicating that the current construction industry is in a rapid development stage. In order to improve the development quality of the construction industry as much as possible, it is of great significance to develop the whole Process engineering consulting service model. The quality evaluation of whole process engineering consulting service modes is MAGDM. The single-valued neutrosophic sets (SVNSs) …


Fusing Type -2 Neutrosophic In Decision-Making Methodology For Appreciation Blockchain Capabilities In Securing Environment Of Vehicles Fog: Practice Realistic Scenarios, Alaa Salem, Mona Mohamed Jun 2024

Fusing Type -2 Neutrosophic In Decision-Making Methodology For Appreciation Blockchain Capabilities In Securing Environment Of Vehicles Fog: Practice Realistic Scenarios, Alaa Salem, Mona Mohamed

Neutrosophic Sets and Systems

Right now, Contemporary technologies have become imperative in many domains to achieve societal safety. As is practiced in transportation systems through merging information and communication technologies (ICTs) in transportation to be an intelligent sector. As well Internet of Vehicles (IoVs) for facilitating communication between vehicles for safe driving. Similarly, fog computing in Vehicular Ad Hoc Networking (VANET) contributes significantly to addressing timing and latency issues by enabling cloud services for nearby vehicles. Nonetheless, there are hazards of cyber-attacks on vehicles in VFN, which makes it uneasy to disclose personal information to unidentified fog devices. Consequently, an online criminal might target …


Pentapartitioned Neutrosophic Subtraction Algebra, Rakhal Das, Suman Das Jun 2024

Pentapartitioned Neutrosophic Subtraction Algebra, Rakhal Das, Suman Das

Neutrosophic Sets and Systems

This paper aims to define the concepts of Semi-group and Pentapartitioned Neutrosophic Subtraction Algebra. We also examine a few of their fundamental characteristics. Additionally, we provide a few appropriate instances on Pentapartitioned Neutrosophic Subtraction Algebra.


On Nct- Set Theory, Dheargham Ali Abdulsada, L. A. A. Al-Swidi, Mustafa H. Hadi Jun 2024

On Nct- Set Theory, Dheargham Ali Abdulsada, L. A. A. Al-Swidi, Mustafa H. Hadi

Neutrosophic Sets and Systems

We introduce a new class of neutrosophic crisp set, and then it presented some operations via this sets like, ������ −intersection, ������ −union and algebraic ������−difference to arrive at the algebraic ring construction. Also, we introduce the ������ − points, which showed that a ������ –set is ������−union of its ������−points, and so did we introduced the concept of the function on this sets, called ������ – function and some of their important properties. Finally, we introduced the concept of the topology and some of the concepts entrusted to it, as an introduction to those spaces that can be studied …


Assessment Of Deep Learning Techniques For Bone Fracture Detection Under Neutrosophic Domain, Doaa El-Shahat, Ahmed Tolba Jun 2024

Assessment Of Deep Learning Techniques For Bone Fracture Detection Under Neutrosophic Domain, Doaa El-Shahat, Ahmed Tolba

Neutrosophic Sets and Systems

With the increasing strain on the health system, there is a growing need for automatic medical image diagnosis. Emerging technologies for medical diagnosis can help to achieve the goals of sustainable development. However, analyzing medical images can be challenging due to uncertain data, ambiguity, and impreciseness. To address this issue, we have developed a novel BoneNet-NS technique to classify fractures in X-ray bone images. The proposed approach is based on the power of deep learning (DL) and neutrosophic set (NS) to deal with aleatoric uncertainty. Moreover, we present two frameworks for integrating NS with DL models: BoneNet-NS1 and BoneNet-NS2. We …


Neutrosophic Spherical Sets In Mcdm, S. Bhuvaneshwari, C. Antony Crispin Sweety Jun 2024

Neutrosophic Spherical Sets In Mcdm, S. Bhuvaneshwari, C. Antony Crispin Sweety

Neutrosophic Sets and Systems

Decision-making plays a crucial role in achieving success across various scenarios, especially when confronted with complex issues inundated with abundant facts and information. Employing multi criteria decision-making (MCDM) methods and techniques becomes particularly indispensable in tackling such formidable challenges. This study introduces novel neutrosophic SWGM and SWAM accuracy functions, which enhance traditional aggregation operators. Furthermore, it introduces the CODAS technique tailored for addressing Multiple Attribute Group Decision Making problems utilizing the newly defined operators. To exemplify the proposed methodology, a supplier selection problem is examined.


The Indefinite Refined Neutrosophic Integrals By Parts, Yaser Ahmad Alhasan, Ahmad Abdullah Almekhlef, Mohamed Elghazali Ali Mohieldin Mohamed, Raja Abdullah Abdulfatah Jun 2024

The Indefinite Refined Neutrosophic Integrals By Parts, Yaser Ahmad Alhasan, Ahmad Abdullah Almekhlef, Mohamed Elghazali Ali Mohieldin Mohamed, Raja Abdullah Abdulfatah

Neutrosophic Sets and Systems

this article's goal is to present the indefinite refined neutrosophic integrals by parts. All situations where integration by parts can be used are covered, including the use of rotating integrals to solve recurring and non-terminating functions like the product of trigonometric and exponential functions. Furthermore, the Tabular method has been implemented in the computation of the indefinite refined neutrosophic integrals


A Robust Framework For Medical Diagnostics Based On Interval-Valued Q-Neutrosophic Soft Sets With Aggregation Operators, Enad Ghazi, Sinan O. Al-Salihi Jun 2024

A Robust Framework For Medical Diagnostics Based On Interval-Valued Q-Neutrosophic Soft Sets With Aggregation Operators, Enad Ghazi, Sinan O. Al-Salihi

Neutrosophic Sets and Systems

The best way to deal with complicated life scenarios that accompany the decision-making process is to update previous concepts constantly. Therefore, researchers must constantly discover powerful mathematical tools that suit the accompanying circumstances. In this regard, we combine both soft set, neutrosophic set, and interval setting under Q-two-dimensional universal information to introduce a new hybrid innovative model called interval valued-Q-neutrosophic soft sets. The core goal of this model is to keep the features of previous models like soft sets, neutrosophic sets, and Q-Fuzzy sets in dealing with the lack of uncertainty and neutrality associated with real-life issues. This new approach …


Evaluation Of The Shortest Path Based On The Traveling Salesman Problem With A Genetic Algorithm In A Neutrosophic Environment, Prasanta Kumar Raut, Siva Prasad Behera, Said Broumi, Arindam Dey, Mohamed Talea, Amarendra Baral Jun 2024

Evaluation Of The Shortest Path Based On The Traveling Salesman Problem With A Genetic Algorithm In A Neutrosophic Environment, Prasanta Kumar Raut, Siva Prasad Behera, Said Broumi, Arindam Dey, Mohamed Talea, Amarendra Baral

Neutrosophic Sets and Systems

In The traveling salesman problem (TSP) is an essential and the most popular conventional combinatorial optimization network problem in operations research, in which the TSP evaluates the shortest route or path in a network. In TSP, every node has been visited only once, excluding the starting node. In TSP, edge lengths are usually expressed to indicate journey time and expenses instead of distance from a location. The exact arc length can't be predicted because journey times and expenses vary depending on the amount of payload, climate, highway conditions, and so on. As a result, the Neutrosophic numbers introduce a new …


An Integrated Codas Method And Novel Surface-Based Weighted Distance Measures Under Neutrosophic Environment, Madineh Farnam, Gholam Hassan Shirdel, Majid Darehmiraki Jun 2024

An Integrated Codas Method And Novel Surface-Based Weighted Distance Measures Under Neutrosophic Environment, Madineh Farnam, Gholam Hassan Shirdel, Majid Darehmiraki

Neutrosophic Sets and Systems

Information theory provides suitable tools for solving practical problems, particularly multi-criteria decision-making (MCDM) problems under neutrosophic environments. Generally, a wide range of MCDM solution methods are constructed based on distance measures category. The defined distance measures for continuous neutrosophic numbers, especially its trapezoidal type, is very limited rather than discrete type. The main goals of this study is to come up with a way to add two new types of weighted distance measures based on meaningful surfaces: Euclidean and Hamming. To define these measures, all three components of the neutrosophic trapezoidal fuzzy number (truth, indeterminacy, and falsity membership functions) have …


A Hybrid Approach To Micro Vague Topological Space Via Neutrosophic Topological Space, Vargees Vahini T, Trinita Pricilla Jun 2024

A Hybrid Approach To Micro Vague Topological Space Via Neutrosophic Topological Space, Vargees Vahini T, Trinita Pricilla

Neutrosophic Sets and Systems

Plenty of topologists are exploring and discovering multiple forms of topological spaces. The chief objective of the current enquiry is to establish and evaluate an original hybrid topological space named Neutro sophic Micro Vague Topological Space. When contrasted with distinctive fuzzy sets, Neutrosophic Micro Vague sets give more adaptive framework for dealing with uncertainties and obscurity because they allow more nuanced portrayal of the multitude of the elements of inconsistencies. Some of the basic definitions and operations on Neutrosophic Micro Vague Sets are defined and examined with numerical examples. Furthermore,some of the basic algebraic properties of Neutrosophic Micro Vague Sets …


Neutrosophic Ranked Set Sampling Scheme For Estimating Population Mean: An Application To Demographic Data, Rajesh Singh, Anamika Kumari Jun 2024

Neutrosophic Ranked Set Sampling Scheme For Estimating Population Mean: An Application To Demographic Data, Rajesh Singh, Anamika Kumari

Neutrosophic Sets and Systems

The primary goal of this study is to address the limitations of classical statistics in handling am biguous or indeterminate data. The best alternative to classical and fuzzy statistics for handling such data uncertainty is neutrosophic statistics, which is a generalization of both. A generalization of classical statistics, neutrosophic statistics addresses hazy, ambiguous, and unclear information. To achieve this, this manuscript recommends the neutrosophic ranked set sampling approach. We have introduced neutrosophic estimators for estimating the mean of the finite population using auxiliary information under neutrosophic ranked set sampling to address the challenges of estimation of the population mean of …


Treesoft Approach For Refining Air Pollution Analysis: A Case Study, M. Myvizhi, Ahmed A. Metwaly, Ahmed M. Ali Jun 2024

Treesoft Approach For Refining Air Pollution Analysis: A Case Study, M. Myvizhi, Ahmed A. Metwaly, Ahmed M. Ali

Neutrosophic Sets and Systems

The ongoing research employs both the neutrosophic set and the Decision Making and Evaluation Method (DEMATEL) to analyze and determine the factors influencing supplier selection within the realm of Supply Chain Management (SCM). Recognized as a proactive strategy for enhancing performance and securing competitive advantages, DEMATEL guides this investigation. The study utilizes neutrosophic set Theory to refine overall assessments, introducing a novel scale to distinctly represent each value. Through a practical case study focusing on selecting the optimal supplier for a distribution company, the proposed methodology's application is illustrated. The research framework integrates a neutrosophic DEMATEL approach for data collection, …


On Generalized Difference Rough Ideal Statistical Convergence In Neutrosophic Normed Spaces, Manpreet Kaur, Meenakshi Chawla Jun 2024

On Generalized Difference Rough Ideal Statistical Convergence In Neutrosophic Normed Spaces, Manpreet Kaur, Meenakshi Chawla

Neutrosophic Sets and Systems

This article’s main goal is to provide and investigate a novel statistical convergence generalisation for generalized difference sequences in Neutrosophic Normed Spaces (NNS) called rough ideal statistical con vergence. The collection of approximate optimal statistical limit points and cluster points is defined, and their algebraic and topological features are examined. Additionally, we included the relationship for generalized dif ference sequences in NNS between rough I-statistical cluster points and rough I-statistical limit points.


A Survey On Neutrosophic Principles For Inventory Management Problem, Ankit Dubey, Arindam Dey, Said Broumi, Ranjan Kumar Jun 2024

A Survey On Neutrosophic Principles For Inventory Management Problem, Ankit Dubey, Arindam Dey, Said Broumi, Ranjan Kumar

Neutrosophic Sets and Systems

This paper presents a thorough assessment and classi cation of di erent uncertain environments used by researchers to analyze inventory management(IM) systems across various sectors, such as ABC anal ysis, Last In, First Out (LIFO), and batch tracking. Moreover, it introduces the concepts of the neutrosophic principle and fuzzy principle in inventory management. it also investigates the di culties associated with the traditional inventory model. The primary focus of the study lies in inventory management under the Neu trosophic principle, speci cally addressing uncertain demand and imprecise data. By shedding light on the potential of neutrosophic principle, this manuscript contributes …


On Rough Statistical Convergence In Neutrosophic Normed Spaces, Reena Antal, Meenakshi Chawla, Vijay Kumar Jun 2024

On Rough Statistical Convergence In Neutrosophic Normed Spaces, Reena Antal, Meenakshi Chawla, Vijay Kumar

Neutrosophic Sets and Systems

In this paper, we have presented rough statistical convergence of sequence on neutrosophic normed spaces as an important convergence criterion. As neutrosophication can handle partially dependent compo nents, partially independent components and even independent components involved in real-world problems. By examining some properties related to rough convergence in these spaces we provide some useful functional tools in the situations of inconsistency and indeterminacy in the real world. Further, we have established some equivalent conditions on the set of statistical limit points as well as on the set of cluster points in these spaces for rough statistically convergent sequences.


Neutrosophic Sets And Systems, Vol. 68,2024, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi Jun 2024

Neutrosophic Sets And Systems, Vol. 68,2024, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi

Neutrosophic Sets and Systems

the whole volume


New Horizons In Peripheral Artery Disease, John S.M. Houghton, Athanasios N. Saratzis, Rob D. Sayers, Victoria J. Haunton Jun 2024

New Horizons In Peripheral Artery Disease, John S.M. Houghton, Athanasios N. Saratzis, Rob D. Sayers, Victoria J. Haunton

Peninsula Medical School

Peripheral artery disease (PAD) is the lower limb manifestation of systemic atherosclerotic disease. PAD may initially present with symptoms of intermittent claudication, whilst chronic limb-threatening ischaemia (CLTI), the end stage of PAD, presents with rest pain and/or tissue loss. PAD is an age-related condition present in over 10% of those aged ≥65 in high-income countries. Guidelines regarding definition, diagnosis and staging of PAD and CLTI have been updated to reflect the changing patterns and presentations of disease given the increasing prevalence of diabetes. Recent research has changed guidelines on optimal medical therapy, with low-dose anticoagulant plus aspirin recommended in some …


Omicsmic: A Comprehensive Benchmarking Platform For Robust Comparison Of Imputation Methods In Mass Spectrometry-Based Omics Data, Weiqiang Lin, Jiadong Ji, Kuan-Jui Su, Chuan Qiu, Qing Tian, Lan-Juan Zhao, Zhe Luo, Chong Wu, Hui Shen, Hongwen Deng Jun 2024

Omicsmic: A Comprehensive Benchmarking Platform For Robust Comparison Of Imputation Methods In Mass Spectrometry-Based Omics Data, Weiqiang Lin, Jiadong Ji, Kuan-Jui Su, Chuan Qiu, Qing Tian, Lan-Juan Zhao, Zhe Luo, Chong Wu, Hui Shen, Hongwen Deng

Faculty, Staff and Student Publications

Mass spectrometry is a powerful and widely used tool for generating proteomics, lipidomics and metabolomics profiles, which is pivotal for elucidating biological processes and identifying biomarkers. However, missing values in mass spectrometry-based omics data may pose a critical challenge for the comprehensive identification of biomarkers and elucidation of the biological processes underlying human complex disorders. To alleviate this issue, various imputation methods for mass spectrometry-based omics data have been developed. However, a comprehensive comparison of these imputation methods is still lacking, and researchers are frequently confronted with a multitude of options without a clear rationale for method selection. To address …


Faculty Onboarding For Workforce Readiness And Belonging, Melissa M. Masaracchia, Scott D. Markowitz, Norah R. Janosy, Kim M. Strupp Jun 2024

Faculty Onboarding For Workforce Readiness And Belonging, Melissa M. Masaracchia, Scott D. Markowitz, Norah R. Janosy, Kim M. Strupp

2020-Current year OA Pubs

INTRODUCTION: An academic anesthesiology department benefits from recruiting faculty from various centers, from new graduates to experienced clinicians. Two critical objectives for a department are getting the faculty members up-to-speed thoroughly and efficiently and retaining the faculty members to benefit from their contributions over time. Onboarding plays a pivotal role in meeting both objectives. A successful onboarding process is critical to the enculturation of new employees into an existing work environment. Organizations focusing on improving onboarding practices increase overall success, decrease attrition, and enhance member performance and satisfaction. In this study, we examine our onboarding practices and then create structured …


Takotsubo Syndrome In Patients With Covid-19: A Systematic Review, Xiaojia Lu, Catherine Teng, Peng Cai, Jing Liang, Yanxuan Wang, Hawa Abu, Yuan Jia Wang, John E Madias, Kan Liu, Qi Liu, Pengyang Li Jun 2024

Takotsubo Syndrome In Patients With Covid-19: A Systematic Review, Xiaojia Lu, Catherine Teng, Peng Cai, Jing Liang, Yanxuan Wang, Hawa Abu, Yuan Jia Wang, John E Madias, Kan Liu, Qi Liu, Pengyang Li

2020-Current year OA Pubs

BACKGROUND: Respiratory conditions are major physical triggers of takotsubo syndrome (TTS) and portend worse outcomes. However, data on TTS in patients with coronavirus disease-2019 infection (COVID-19) are limited.

METHODS: We searched PubMed, Embase, and Cochrane Library databases for case reports for the period 2019-2022 describing TTS in patients with COVID-19 pneumonia (TTS-COVID). We summarized the clinical data and outcomes and compared them to those in patients with TTS with an acute respiratory disease other than COVID-19 as a trigger (TTS-acute respiratory disease) and those with TTS with no respiratory disease (TTS-no respiratory disease).

RESULTS: The mortality rate was higher in …


Chloride/Proton Antiporters Clc3 And Clc5 Support Bone Formation In Mice, Irina L Tourkova, Quitterie C Larrouture, Silvia Liu, Jianhua Luo, Katherine E Shipman, Kelechi M Onwuka, Ora A Weisz, Vladimir Riazanski, Deborah J Nelson, Matthew L Macdonald, Paul H Schlesinger, Harry C Blair Jun 2024

Chloride/Proton Antiporters Clc3 And Clc5 Support Bone Formation In Mice, Irina L Tourkova, Quitterie C Larrouture, Silvia Liu, Jianhua Luo, Katherine E Shipman, Kelechi M Onwuka, Ora A Weisz, Vladimir Riazanski, Deborah J Nelson, Matthew L Macdonald, Paul H Schlesinger, Harry C Blair

2020-Current year OA Pubs

Acid transport is required for bone synthesis by osteoblasts. The osteoblast basolateral surface extrudes acid by Na


Haptic Curing With Endolaser After Lens Tilt In The Yamane Technique, James C Liu, Arsham Sheybani Jun 2024

Haptic Curing With Endolaser After Lens Tilt In The Yamane Technique, James C Liu, Arsham Sheybani

2020-Current year OA Pubs

PURPOSE: To describe a case of intraocular lens (IOL) tilt following transscleral IOL fixation with the Yamane technique and subsequent correction of tilt using 810-nm endoscopic diode laser.

OBSERVATIONS: Our patient required lens exchange and secondary IOL implantation due to a dislocated 1-piece IOL in the bag causing iris chafe. After routine IOL fixation with the Yamane technique and a Zeiss CT Lucia 602 lens, the IOL tilted significantly in the immediate postoperative period. The lens tilt was subsequently corrected in the operating room using endolaser to melt and reshape (cure) the optic-haptic junction.

CONCLUSIONS: IOL tilt is a known …


Skeletal Abnormalities In Mice With Dnmt3a Missense Mutations, Austin Bell-Hensley, Diana C Beard, Kathryn Feeney, Hongjun Zheng, Yunhao Jiang, Xiyun Zhang, Jin Liu, Harrison Gabel, Audrey Mcalinden Jun 2024

Skeletal Abnormalities In Mice With Dnmt3a Missense Mutations, Austin Bell-Hensley, Diana C Beard, Kathryn Feeney, Hongjun Zheng, Yunhao Jiang, Xiyun Zhang, Jin Liu, Harrison Gabel, Audrey Mcalinden

2020-Current year OA Pubs

Overgrowth and intellectual disability disorders in humans are typified by length/height and/or head circumference ≥ 2 standard deviations above the mean as well as intellectual disability and behavioral comorbidities, including autism and anxiety. Tatton-Brown-Rahman Syndrome is one type of overgrowth and intellectual disability disorder caused by heterozygous missense mutations in the DNA methyltransferase 3A (DNMT3A) gene. Numerous DNMT3A mutations have been identified in Tatton-Brown-Rahman Syndrome patients and may be associated with varying phenotype severities of clinical presentation. Two such mutations are the R882H and P904L mutations which result in severe and mild phenotypes, respectively. Mice with paralogous mutations (Dnmt3a


Ethological Computational Psychiatry: Challenges And Opportunities, Ilya E Monosov, Jan Zimmermann, Michael J Frank, Mackenzie W Mathis, Justin T Baker Jun 2024

Ethological Computational Psychiatry: Challenges And Opportunities, Ilya E Monosov, Jan Zimmermann, Michael J Frank, Mackenzie W Mathis, Justin T Baker

2020-Current year OA Pubs

Studying the intricacies of individual subjects' moods and cognitive processing over extended periods of time presents a formidable challenge in medicine. While much of systems neuroscience appropriately focuses on the link between neural circuit functions and well-constrained behaviors over short timescales (e.g., trials, hours), many mental health conditions involve complex interactions of mood and cognition that are non-stationary across behavioral contexts and evolve over extended timescales. Here, we discuss opportunities, challenges, and possible future directions in computational psychiatry to quantify non-stationary continuously monitored behaviors. We suggest that this exploratory effort may contribute to a more precision-based approach to treating mental …


Prioritization Of Kidney Cell Types Highlights Myofibroblast Cells In Regulating Human Blood Pressure, Mahboube Ganji-Arjenaki, Zoha Kamali, International Consortium Of Blood Pressure; Soroush Sardari, Soroush Sardari, Martin De Borst, Harold Snieder, Ahmad Vaez Jun 2024

Prioritization Of Kidney Cell Types Highlights Myofibroblast Cells In Regulating Human Blood Pressure, Mahboube Ganji-Arjenaki, Zoha Kamali, International Consortium Of Blood Pressure; Soroush Sardari, Soroush Sardari, Martin De Borst, Harold Snieder, Ahmad Vaez

Faculty, Staff and Student Publications

INTRODUCTION: Blood pressure (BP) is a highly heritable trait with over 2000 underlying genomic loci identified to date. Although the kidney plays a key role, little is known about specific cell types involved in the genetic regulation of BP.

METHODS: Here, we applied stratified linkage disequilibrium score (LDSC) regression to connect BP genome-wide association studies (GWAS) results to specific cell types of the mature human kidney. We used the largest single-stage BP genome-wide analysis to date, including up to 1,028,980 adults of European ancestry, and single-cell transcriptomic data from 14 mature human kidneys, with mean age of 41 years.

RESULTS: …


Chagasin From Trypanosoma Cruzi As A Molecular Scaffold To Express Epitopes Of Tsa-1 As Soluble Recombinant Chimeras, Rosa Elena Cárdenas-Guerra, Octavio Montes-Flores, Edgar Ezequiel Nava-Pintor, Gerardo Reséndiz-Cardiel, Claudia Ivonne Flores-Pucheta, Yasmín Irene Rodríguez-Gavaldón, Rossana Arroyo, Maria Elena Bottazzi, Peter J Hotez, Jaime Ortega-López Jun 2024

Chagasin From Trypanosoma Cruzi As A Molecular Scaffold To Express Epitopes Of Tsa-1 As Soluble Recombinant Chimeras, Rosa Elena Cárdenas-Guerra, Octavio Montes-Flores, Edgar Ezequiel Nava-Pintor, Gerardo Reséndiz-Cardiel, Claudia Ivonne Flores-Pucheta, Yasmín Irene Rodríguez-Gavaldón, Rossana Arroyo, Maria Elena Bottazzi, Peter J Hotez, Jaime Ortega-López

Faculty, Staff and Students Publications

Trypanosoma cruzi is the causative agent of Chagas disease, a global public health problem. New therapeutic drugs and biologics are needed. The TSA-1 recombinant protein of T. cruzi is one such promising antigen for developing a therapeutic vaccine. However, it is overexpressed in E. coli as inclusion bodies, requiring an additional refolding step. As an alternative, in this study, we propose the endogenous cysteine protease inhibitor chagasin as a molecular scaffold to generate chimeric proteins. These proteins will contain combinations of two of the five conserved epitopes (E1 to E5) of TSA-1 in the L4 and L6 chagasin loops. Twenty …