Digital Commons Network^™

Evaluating The Impact Of A 2-Week Peer Enhanced E-Placement (Peep) On Pre-Registration Physiotherapy Students’ Attitudes, Self-Perceived Confidence, And Competence In Delivering Telerehabilitation., Christie Robinson, Sarah Buckingham, Jennifer Freeman

School of Health Professions

The COVID-19 pandemic brought about rapid digital transformation of physiotherapy practice and education. Previous studies have suggested a lack of knowledge, beliefs, and clinical acceptance of telerehabilitation as barriers to implementation and sustainability of telerehabilitation. Providing pre-registration specific teaching and practical experience of telerehabilitation may improve physiotherapy student confidence and competence in delivering telerehabilitation and support clinical acceptance of telerehabilitation in practice. A 2-week Peer Enhanced E-Placement (PEEP) was developed and evaluated to explore its impact on third year physiotherapy student attitudes, and perceived competence and confidence in delivering telerehabilitation. Students completed a Likert scale questionnaire, immediately pre and post …

Advancing Influence In Social Networks Based On Game Theory, Adedamola Adesokan

Electrical and Computer Engineering ETDs

Online Social Networks (OSNs) have become part of our everyday life, as a means of interacting with people, sharing content, attending events, etc. Influencers are professional OSN users, who have a large loyal audience and use the OSNs to market various goods or services based on brand partnerships. In this thesis, we introduce a novel mechanism to enable OSN users to become influencers by strategically deciding their activity within the OSN. Initially, the concepts of social coordinates and social communities are proposed. Then, a non-cooperative game is introduced to enable the users to make optimal decisions regarding their activity in …

Type I Conventional Dendritic Cells Facilitate Immunotherapy In Pancreatic Cancer, Krishnan K Mahadevan, Allison M Dyevoich, Yang Chen, Bingrui Li, Hikaru Sugimoto, Kathleen M Mcandrews, Huamin Wang, Shabnam Shalapour, Stephanie S Watowich, Raghu Kalluri

Faculty, Staff and Student Publications

Inflammation and tissue damage associated with pancreatitis can precede or occur concurrently with pancreatic ductal adenocarcinoma (PDAC). We demonstrate that in PDAC coupled with pancreatitis (ptPDAC), antigen-presenting type I conventional dendritic cells (cDC1s) are specifically activated. Immune checkpoint blockade therapy (iCBT) leads to cytotoxic CD8+ T cell activation and elimination of ptPDAC with restoration of life span even upon PDAC rechallenge. Using PDAC antigen-loaded cDC1s as a vaccine, immunotherapy-resistant PDAC was rendered sensitive to iCBT with elimination of tumors. cDC1 vaccination coupled with iCBT identified specific CDR3 sequences in the tumor-infiltrating CD8+ T cells with potential therapeutic importance. This study …

Kibra Anchoring The Action Of Pkmζ Maintains The Persistence Of Memory, Panayiotis Tsokas, Changchi Hsieh, Rafael E Flores-Obando, Matteo Bernabo, Andrew Tcherepanov, Christian Thomas, James E Cottrell, Joachim Kremerskothen, Harel Z Shouval, Karim Nader, André A Fenton, Todd C Sacktor

Faculty, Staff and Student Publications

How can short-lived molecules selectively maintain the potentiation of activated synapses to sustain long-term memory? Here, we find kidney and brain expressed adaptor protein (KIBRA), a postsynaptic scaffolding protein genetically linked to human memory performance, complexes with protein kinase Mzeta (PKMζ), anchoring the kinase's potentiating action to maintain late-phase long-term potentiation (late-LTP) at activated synapses. Two structurally distinct antagonists of KIBRA-PKMζ dimerization disrupt established late-LTP and long-term spatial memory, yet neither measurably affects basal synaptic transmission. Neither antagonist affects PKMζ-independent LTP or memory that are maintained by compensating PKCs in ζ-knockout mice; thus, both agents require PKMζ for their effect. …

Author Correction: Plasmonic Nano-Aperture Label-Free Imaging Of Single Small Extracellular Vesicles For Cancer Detection, Nareg Ohannesian, Mohammad Sadman Mallick, Jianzhong He, Yawei Qiao, Nan Li, Chad Tang, Wayne L Hofstetter, Alexei Goltsov, Manal M Hassan, Kelly K Hunt, Steven H Lin, Wei-Chuan Shih

Faculty, Staff and Student Publications

No abstract provided.

Randomized Controlled Trial Of Enteral Vitamin D Supplementation (Vides) In Infants <28 Weeks Gestational Age Or <1000 G Birth Weight: Study Protocol, Lindsay F Holzapfel, Matthew Rysavy

Faculty, Staff and Student Publications

BACKGROUND: Vitamin D is necessary to develop healthy lungs and other organs early in life. Most infants born before 28 weeks' gestation have low vitamin D levels at birth and a limited intake during the first month. Enteral vitamin D supplementation is inexpensive and widely used. The appropriate supplementation regimen for extremely preterm infants is controversial, and the effect of different regimens on their blood levels and outcomes is unclear.

METHODS: Randomized, blinded comparative effectiveness trial to compare two vitamin D supplementation regimens for inborn infants(400 IU/day with established feedings) or increased supplementation (800 IU/day with any feedings) during the …

Aging- And Alcohol-Associated Spatial Transcriptomic Signature In Mouse Acute Pancreatitis Reveals Heterogeneity Of Inflammation And Potential Pathogenic Factors, Jiajing Li, Qiang Shen, Jennifer M Bailey-Lundberg, Zhongming Zhao, Daniel Kraushaar, Patricia Castro, Yanna Cao, W Jim Zheng, Tien C Ko

Faculty, Staff and Student Publications

The rapidly aging population is consuming more alcohol, leading to increased alcohol-associated acute pancreatitis (AAP) with high mortality. However, the mechanisms remain undefined, and currently there are no effective therapies available. This study aims to elucidate aging- and alcohol-associated spatial transcriptomic signature by establishing an aging AAP mouse model and applying Visium spatial transcriptomics for understanding of the mechanisms in the context of the pancreatic tissue. Upon alcohol diet feeding and caerulein treatment, aging mice (18 months) developed significantly more severe AAP with 5.0-fold increase of injury score and 2.4-fold increase of amylase compared to young mice (3 months). Via …

Online Teacher-Student Rapport In Higher Education, Joshua Fitzgerald

Theses and Dissertations

Rapport developed between teachers and students in a typical classroom setting can provide students with a more positive school experience, an increase in learning and performance, and added feelings of social belonging (Cook, et al., 2018). Online learning is associated with many advantages like a more comfortable setting for students to participate (Majewska & Zvobgo, 2023), but also includes disadvantages like feelings of isolation (Phirangee & Malec, 2020) which can result in rapport being more difficult to develop. Established rapport during online educational settings can yield a multitude of positive outcomes for online students and teachers alike. These outcomes include …

Unified Worldline Treatment Of Yukawa And Axial Couplings, F. Bastianelli, O. Corradini, J. P. Edwards, D. G. C. Mckeon, C. Schubert

School of Engineering, Computing and Mathematics

We provide a worldline representation of the one-loop effective action for a Dirac particle coupled to external scalar, pseudoscalar, vector and axialvector fields. Extending previous work by two of the authors on the pure vector-axialvector case to all four couplings, it allows one to treat the real and the imaginary parts of the effective action in a unified manner, at the price of having a non-Hermitian Hamiltonian. Unlike existing worldline representations, our new worldline action contains terms with an odd number of Grassmann fields, leading to ordering problems that in the worldline formalism are usually encountered only in curved space. …

The Electric Seaway, Keri Collins, Simon Ussher, Amir Bordbar, Marcin Roszkowski, Anthony Wilson

School of Engineering, Computing and Mathematics

No abstract provided.

Teaching Bioinformatics Through The Analysis Of Sars-Cov-2: Project-Based Training For Computer Science Students, Blaž Zupan

Faculty, Staff and Students Publications

MOTIVATION: We learn more effectively through experience and reflection than through passive reception of information. Bioinformatics offers an excellent opportunity for project-based learning. Molecular data are abundant and accessible in open repositories, and important concepts in biology can be rediscovered by reanalyzing the data.

RESULTS: In the manuscript, we report on five hands-on assignments we designed for master's computer science students to train them in bioinformatics for genomics. These assignments are the cornerstones of our introductory bioinformatics course and are centered around the study of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). They assume no prior knowledge of molecular …

Python Tooth-Inspired Fixation Device For Enhanced Rotator Cuff Repair, Iden Kurtaliaj, Ethan D Hoppe, Yuxuan Huang, David Ju, Jacob A Sandler, Donghwan Yoon, Guy M Genin

2020-Current year OA Pubs

Rotator cuff repair surgeries fail frequently, with 20 to 94% of the 600,000 repairs performed annually in the United States resulting in retearing of the rotator cuff. The most common cause of failure is sutures tearing through tendons at grasping points. To address this issue, we drew inspiration from the specialized teeth of snakes of the Pythonoidea superfamily, which grasp soft tissues without tearing. To apply this nondamaging gripping approach to the surgical repair of tendon, we developed and optimized a python tooth-inspired device as an adjunct to current rotator cuff suture repair and found that it nearly doubled repair …

Extracorporeal Membrane Oxygenation For Respiratory Failure: A Narrative Review, John C Grotberg, Daniel Reynolds, Bryan D Kraft

2020-Current year OA Pubs

Extracorporeal membrane oxygenation support for respiratory failure in the intensive care unit continues to have an expanded role in select patients. While acute respiratory distress syndrome remains the most common indication, extracorporeal membrane oxygenation may be used in other causes of refractory hypoxemia and/or hypercapnia. The most common configuration is veno-venous extracorporeal membrane oxygenation; however, in specific cases of refractory hypoxemia or right ventricular failure, some patients may benefit from veno-pulmonary extracorporeal membrane oxygenation or veno-venoarterial extracorporeal membrane oxygenation. Patient selection and extracorporeal circuit management are essential to successful outcomes. This narrative review explores the physiology of extracorporeal membrane oxygenation, …

The Lived Experience Of Stigmatization Due To Chemotherapy-Induced Hair Loss For Young Women With Cancer Who Attend College, Challna Blair

Walden Dissertations and Doctoral Studies

This study investigated the stigmatization experienced by young women in college due to chemotherapy-induced hair loss. Previous research primarily focused on older women, adolescents, and men, leaving a gap in understanding the impact on young college-age women. Using Goffman’s theory of stigma and Giorgi’s descriptive phenomenological method, six young women were interviewed confidentially. The primary research question asked what is the experience of stigma in young women in college who have hair loss during or following chemotherapy cancer treatment? The study revealed that these women often faced being ostracized by peers, received minimal family support, and experienced distressing scrutiny from …

Manufacturing Strategies For Optimizing Supply Chains And Mitigating Disruption, Rudolph Smith

Walden Dissertations and Doctoral Studies

Shifts in consumer demands, access to raw materials, and rapid growth can influence supply chain performance. Tool and Die (T&D) manufacturing leaders tend to be concerned with ineffective supply chains, which can harm firms’ competitiveness and profitability. Grounded in Porter’s Value Chain theory, the purpose of this qualitative pragmatic inquiry was to identify and explore strategies that some leaders in the U.S. tool and die industry use to manage supply chains successfully. The participants were five T&D manufacturing leaders in the eastern United States who successfully managed T&D supply chains. Data were collected using purposeful sampling via semistructured interviews and …

Interval Training Using A Slide Board Is Superior To Cycloergometer Regarding Aerobic Capacity And Specific Fitness In Elite Ice Hockey Players, Robert Roczniok, Artur Terbalyan, Daria Manilewska, Grzegorz Mikrut, Tomas Mika, Petr Stastny

Baltic Journal of Health and Physical Activity

Introduction: Ice hockey is a physically demanding sport that requires a combination of aerobic and anaerobic capacities, as well as specific on-ice skills. This study aimed to compare the effectiveness of individualized interval training on a slide board with training on a cyclo-ergometer, focusing on aerobic capacity and specific fitness in elite ice hockey players. Materials and Methods: Thirty players were randomly divided into an experimental (slide board) and a control (cyclo-ergometer) group. Both groups underwent a 6-week training program with the same intensity and volume. Results: The results showed that both forms of training led to significant improvements in …

Creation/Extension Of Software-Defined Fabric Using Networking Llms With Augmented Learning, Prakash C Jain, Sanjay K Hooda

Defensive Publications Series

Large Language Models (LLMs) can be used in a variety of environments to enhance user experience/understanding of information related to different scenarios. However, in the context of software-defined fabric management and/or design tasks, an LLM may provide responses to fabric management/design queries that may be of limited use to a network operator. Proposed herein are techniques for augmenting dynamic runtime information (e.g., topology, configuration, events, etc.) of a software-defined fabric to an LLM using a vector database to enable the LLM to provide recommendations to a user/administrator of the fabric that are based on the context as opposed to providing …

Table Of Contents, Nicholas Conti

The Journal of Business, Entrepreneurship & the Law

No abstract provided.

Rights In Conflict: Examining Investment Treaty Arbitration And Intellectual Property Rights In The Wake Of Russia’S Invasion Of Ukraine, Grace Klutke

The Journal of Business, Entrepreneurship & the Law

This article examines how the armed Ukraine-Russia conflict opened a doorway for a wave of international arbitration via corporate actions against Russia for violating BIT obligations. To provide context for the suggested BIT arbitration against Russia, this article begins with a brief discussion of the historical background of this conflict and investor-state treaty arbitration. This article next pivots to analyze the applicability of investor-state treaty arbitration to compensate lost IP investments in three parts. Part I considers how investor-state treaty arbitration function with ongoing armed conflict and which investors may initiate investor-state treaty claims. Next, Part II reports on the …

Box Office Knockout: The Future Of Theaters In An Industry Racing To Outpace Them, Jakob Stokes

The Journal of Business, Entrepreneurship & the Law

This article examines the historical and contemporary impacts of antitrust measures in the film industry, focusing on the significant Paramount Decrees which initially aimed to dismantle the monopolistic practices of the "Big Five" and "Little Three" studios. It discusses the evolution of these decrees and their relevance in today's landscape dominated by a new set of major players. The article further explores the current debate surrounding the shortening of the cinematic window of exclusivity, delving into the implications of various premium video on demand services, such as Disney Premier Access, and the arguments both for and against shortened windows. It …

The Legal Liabilities Of Twitch, Amazon’S Livestreaming Subsidiary, Jean Fang

The Journal of Business, Entrepreneurship & the Law

Amazon’s Twitch is the leader of the video game streaming market, controlling 76% of this market in the Americas and Europe. The video gaming market is rapidly expanding, exceeding its entertainment counterparts, including music and film, by wide margins in profits; experts valued the global gaming market at $229.39 billion in 2022 and expect it to grow to $401.32 billion by 2027. Amazon paid $1 billion to acquire Twitch in 2014 in a business move to capture the views of the gaming audience; on Twitch, popular streamers broadcast themselves playing video games to thousands of devoted fans. Based on recent …

Can Online-Only Businesses Constitute Places Of Public Accommodation Under Title Iii Of The Ada?, Nicholas Conti

The Journal of Business, Entrepreneurship & the Law

Central to this article is the significant Disability Rights Movement, which aimed to provide equal opportunity and equal access to people with disabilities, while rallying against negative stereotypes and advocating for institutional change. In Martinez v. Cot’n Wash, Inc., the California Court of Appeal for the Second District applied a strict method of textual interpretation to decide that, absent any nexus to a physical location or storefront, a website by itself cannot constitute a place of public accommodation under Title III of the ADA. Part II provides an overview of the Americans with Disabilities Act, focusing on a modern conflict …

Going Cashless: Privacy Implications For Gun Control In A Digital Economy, Liza Goldenberg

The Journal of Business, Entrepreneurship & the Law

This paper will examine how, given the United States’ shift toward a cashless economy, the country’s top credit-card companies’ potential decision to implement a new merchant code for firearm-related transactions as a method of gun control will backfire, jeopardizing consumer privacy and leading to unregulated transactions through cryptocurrencies. Since the majority of gun violence stems from firearm transactions not involving credit cards, credit-card companies should abandon the new merchant code that dissuades Americans from exercising their fundamental rights. The American economy should focus on slowing the shift toward a digital economy so that federal and state governments can implement legislation …

Unfairly Interchangeable: A Guide For Litigating The Alter Ego Doctrine And Proposal To Codify The Doctrine In California, Nazgole Hashemi

The Journal of Business, Entrepreneurship & the Law

This article details various aspects of the “alter ego” doctrine to promote a better and more thorough understanding amongst practitioners. Part II details the substantive aspects of the doctrine, i.e., the two prongs—unity of interest and ownership and whether a corporation’s separate existence would promote injustice or perpetuate fraud. It also analyzes whether and when reverse piercing is recognized in California. Part III describes the procedural aspects of the doctrine, including how and when to pursue it in litigation, while also providing practical litigation tips. Part IV sets forth the author’s proposal for the California legislature to codify the doctrine …

Death, Taxes, And Clean Energy: How The Inflation Reduction Act Harnesses Tax Law To Revitalize American Clean Energy, James A. Ferguson

The Journal of Business, Entrepreneurship & the Law

This article explores the nature and impact of the IRA’s historic tax reform on U.S. clean energy markets, emphasizing its significance for businesses, American workers, the global community, and the climate. It begins with an overview of federal tax credits for clean energy, comparing German and American approaches to incentivizing clean energy investments. The article then details five key provisions of the IRA, including extensions of the ITC and PTC, creation of new credits, transferability of tax credits, prevailing wage and apprenticeship requirements, and additional tax credits for domestic content and siting. It further analyzes the IRA’s practical implications for …

Applicability Of Discharge Exceptions To Corporate Debtors In Subchapter V: A “Death Blow” To Rescuing Small Businesses, Robert J. Landry Iii

The Journal of Business, Entrepreneurship & the Law

On August 23, 2019, the Small Business Reorganization Act of 2019 (SBRA) was signed into law, adding a new subchapter to Chapter 11 for small business debtors, i.e. “Subchapter V”. The underlying driver for SBRA was a concern that while most Chapters 11 cases are small business debtors, most small business debtors face difficulty successfully reorganizing under Chapter 11. SBRA is intended to streamline Chapter 11 reorganization for small business debtors by making the process quicker and cheaper. However, SBRA arguably curtailed the scope of discharge when a plan is confirmed without the consent of the creditors for corporate small …

Assessing The Benefits Of Simulations And War Games For Homeland Security Enterprise Workforce Development, David Schanzer, Daveed Gartenstein-Ross

NCITE Envision Conference

Slides for the presentation presented at the ENVISION24 Conference Session 8: Lighting Talks: Transformative Workforce Development

Workforce And Professional Development Project: Building Capacity In Hse-Focused Business Analysis Application, A. Erin Bass

NCITE Envision Conference

Slides for the presentation presented at the ENVISION24 Conference Session 8: Lighting Talks: Transformative Workforce Development

Two Lessons In Prevention: What Practitioners Need To Know To Support The Families, Karyn Sporer

NCITE Envision Conference

Slides for the presentation presented at the ENVISION24 Conference Session 8: Lighting Talks: Transformative Workforce Development

Psychological Trauma In Terrorism Research (Pt2r): Identifying Risk Factors And Intervention Points For Work-Related Psychosocial Trauma, Matthew Crayne

NCITE Envision Conference

Slides for the presentation presented at the ENVISION24 Conference Session 8: Lighting Talks: Transformative Workforce Development