Digital Commons Network^™

Do Public Accommodations Laws Compel “What Shall Be Orthodox”?: The Role Of Barnette In 303 Creative Llc V. Eleni, Linda C. Mcclain

Faculty Scholarship

This article addresses the U.S. Supreme Court's embrace, in 303 Creative LLC v. Elenis, of a First Amendment objection to state public accommodations laws that the Court avoided in Masterpiece Cakeshop v. Colorado Civil Rights Commission: such laws compel governmental orthodoxy. These objections invoke West Virginia Board of Education v. Barnette 's celebrated language: "If there is any fixed star in our constitutional constellation, it is that no official, high or petty, can prescribe what shall be orthodox in politics, nationalism, religion or other matters of opinion or force citizens to confess by word or act their faith …

Nivel De Apego Al Tratamiento Farmacológico En Pacientes Con Diabetes Mellitus Tipo 2, Antes Y Después De Una Intervención Educativa, Nora C. Soriano-Becerril, Ana R. Gómez-Fernández, Sergio A. Bonilla-Becerril, José G. Suárez-García

Revista de la ALAD

Antecedentes: El apego al tratamiento farmacológico en la diabetes es una estrategia efectiva para retrasar sus complicaciones. Objetivo: Comparar el nivel de apego al tratamiento en pacientes con diabetes tipo 2 (DT2) antes y después de una intervención educativa. Material y métodos: Se estudiaron 185 pacientes del IMSS con DT2 y con media de edad de 61.15 ± 12.16 años (el 60% mujeres). Se recabaron variables sociodemográficas y se aplicó la escala Morisky-Green de apego al tratamiento farmacológico antes de la intervención. Se efectuó una intervención educativa explicando la importancia del apego al tratamiento farmacológico. Treinta días después se aplicó …

Intervención Psicoeducativa Asistida Por Whatsapp Para Mejorar La Calidad De Vida Y Autoeficacia En Adultos Mayores Con Diabetes Tipo 2, Cristian Richards-Ramírez, Rebeca M.E. Guzmán-Saldaña, Cintia Ramírez-Alvarado, Luis I. Ledesma-Amaya, Abel Lerma, Lilián E. Bosques-Brugada, Ma. Luisa Escamilla-Gutiérrez

Revista de la ALAD

Antecedentes: La diabetes tipo 2 representa una de las principales causas de morbilidad en adultos mayores y afecta significativamente su calidad de vida y capacidades de autocuidado. En este contexto, es fundamental implementar estrategias psicoeducativas accesibles que fortalezcan la autoeficacia y promuevan un manejo integral de la enfermedad. Objetivo: Evaluar el efecto de una intervención psicoeducativa combinada con mensajería instantánea (WhatsApp) sobre la calidad de vida, autoeficacia, y control glucémico en adultos mayores con diabetes tipo 2. Material y métodos: Se utilizó un diseño preexperimental de caso único (n = 1), con medidas repetidas (pretest, postest y seguimiento), en una …

Ask The Professor How Will The Recent U.S. Supreme Court Decision In Jarkesy Impact Past, Current And Future Sec, Cftc And Sro Enforcement Actions?, Ronald Filler

Articles & Chapters

No abstract provided.

Vaso-Lock For Sutureless Anastomosis In A Pig Arteriovenous Loop Model, Xiaowei Li, Emma R Young, Cameron Martin, Joseph G Ribaudo, Mohamed Zaghloul, Sophia Roberts, Rodrigo Meade, Batool Arif, William R Moritz, Sarah Madira, Jonathon B Schofield, Mohamed A Zayed, Justin M Sacks, Et Al.

2020-Current year OA Pubs

A vascular anastomosis is a critical surgical skill that involves connecting blood vessels. Traditional handsewn techniques can be challenging and resource intensive. To address these issues, we have developed a unique sutureless anastomotic device called Vaso-Lock. This intraluminal device connects free vascular ends using anchors to maintain traction and enable a rapid anastomosis. We tested the anastomotic capability of Vaso-Locks in a pig common carotid-internal jugular arteriovenous model. The use of Vaso-Lock allowed us to accomplish this procedure in less than 10 min, in contrast to the approximately 40 min required for a handsewn anastomosis. The Vaso-Lock effectively maintained patency …

Clinician-Perceived Barriers To Cervical Cancer Screening Before And During The Covid-19 Pandemic At Three Us Healthcare Systems, Veronica M Boratyn, Gaia Pocobelli, Steven J Atlas, Cheryl R Clark, Sarah Feldman, Gina Kruse, Anne Marie Mccarthy, Meghan Rieu-Werden, Michelle I Silver, Noel O Santini, Jasmin A Tiro, Jennifer S Haas

2020-Current year OA Pubs

INTRODUCTION: The COVID-19 pandemic posed serious challenges to cancer screening delivery, including cervical cancer. While the impact of the pandemic on deferred screening has been documented, less is known about how clinicians experienced barriers to screening delivery, and, in particular, the role of pre-pandemic barriers to changes reported during the pandemic.

METHODS: Survey of clinicians who performed ≥ 10 cervical cancer screening tests in 2019 from Mass General Brigham, Kaiser Permanente Washington, and Parkland Health, the healthcare systems participating in the Population-based Research to Optimize the Screening Process (PROSPR II) consortium (administered 10/2020-12/2020, response rate 53.7 %).

RESULTS: Prior to …

Origins Of Cancer: Ain't It Just Mature Cells Misbehaving?, Charles J Cho, Jeffrey W Brown, Jason C Mills

2020-Current year OA Pubs

A pervasive view is that undifferentiated stem cells are alone responsible for generating all other cells and are the origins of cancer. However, emerging evidence demonstrates fully differentiated cells are plastic, can be coaxed to proliferate, and also play essential roles in tissue maintenance, regeneration, and tumorigenesis. Here, we review the mechanisms governing how differentiated cells become cancer cells. First, we examine the unique characteristics of differentiated cell division, focusing on why differentiated cells are more susceptible than stem cells to accumulating mutations. Next, we investigate why the evolution of multicellularity in animals likely required plastic differentiated cells that maintain …

Feasibility Of Simulation Free Abdominal Stereotactic Adaptive Radiotherapy Using An Expedited Pre-Plan Workflow, Alex T Price, Joshua P Schiff, Alice Silberstein, Robbie Beckert, Tianyu Zhao, Geoffrey D Hugo, Pamela P Samson, Eric Laugeman, Lauren E Henke

2020-Current year OA Pubs

BACKGROUND AND PURPOSE: Improved hounsfield-unit accuracy of on-board imaging may lead to direct-to-unit treatment approaches We aimed to demonstrate the feasibility of using only a diagnostic (dx) computed tomography (CT)-defined target pre-plan in an

MATERIALS AND METHODS: Eight patients with abdominal treatment sites (five pancreatic cancer, three oligometastases) were treated using an integrated adaptive O-Ring gantry system. Each patient's target was delineated on a dxCT. The target only pre-plan served primarily to seed the ART process. During the ART session, all structures were delineated. All simulated cases were treated to 50 Gy in 5 fractions to a planning target optimization …

Dlg1 Functions Upstream Of Sdccag3 And Ift20 To Control Ciliary Targeting Of Polycystin-2, Csenge K Rezi, Tao Cheng, Jeffrey H Miner, Moe R Mahjoub, Et Al.

2020-Current year OA Pubs

Polarized vesicular trafficking directs specific receptors and ion channels to cilia, but the underlying mechanisms are poorly understood. Here we describe a role for DLG1, a core component of the Scribble polarity complex, in regulating ciliary protein trafficking in kidney epithelial cells. Conditional knockout of Dlg1 in mouse kidney causes ciliary elongation and cystogenesis, and cell-based proximity labeling proteomics and fluorescence microscopy show alterations in the ciliary proteome upon loss of DLG1. Specifically, the retromer-associated protein SDCCAG3, IFT20, and polycystin-2 (PC2) are reduced in the cilia of DLG1-deficient cells compared to control cells. This phenotype is recapitulated in vivo and …

Evaluation Of Markers Of Immunity In Different Metastatic Immune Microenvironments Suggests More Suppression Within Breast To Liver Metastases In Breast Cancer, Robert Hsu, Foluso O Ademuyiwa, Et Al.

2020-Current year OA Pubs

PURPOSE: Programmed death receptor ligand-1 (PD-L1) expression and tumor mutational burden (TMB) are approved screening biomarkers for immune checkpoint inhibition (ICI) in advanced triple negative breast cancer. We examined these biomarkers along with characterization of the tumor microenvironment (TME) between breast tumors (BrTs), axillary metastases (AxMs), liver metastases (LvMs), non-axillary lymph node metastases, and non-liver metastases to determine differences related to site of metastatic disease.

METHODS: 3076 unpaired biopsies from breast cancer patients were analyzed using whole transcriptome sequencing and NextGen DNA depicting TMB within tumor sites. The PD-L1 positivity was determined with VENTANA PD-L1 (SP142) assay. The immune cell …

Snapshot Of U.S. Federal Cases Against Violent Qanon Adherents, Seamus Hughes, Camden Carmichael, Clara Braun

Reports, Projects, and Research

QAnon refers to an anti-establishment conspiracy theory that is promoted by a decentralized online community and has morphed into a real-world movement. Originating on online message boards, the conspiracy that is credited with the formation of QAnon largely began with a post called “the Calm Before the Storm” by an anonymous user known as “Q.” The individual claimed to be a high-level government official with a security clearance level Q who had access to classified information. Though the ideology has evolved over time, central to the QAnon conspiracy theory is the belief that the world is run by a cabal …

Screening For Insider Threats In Us Law Enforcement: A National Sample Of Department Policies And Practices Plain Language Summary, Erin M. Kearns, Sadaf Hashimi, Jessica Huff, Justin Nix, Natalie Cotton

Reports, Projects, and Research

For this project, we conducted multi-pronged formative research on insider threats in U.S. law enforcement. Our main objective was to better understand current policies and procedures to screen for and identify insider threats in the hiring process and among active officers.

Screening For Insider Threats In Us Law Enforcement: A National Sample Of Department Policies And Practices State Of Practice Guide, Erin M. Kearns, Sadaf Hashimi, Jessica Huff, Justin Nix, Natalie Cotton

Reports, Projects, and Research

For decades, violent extremist groups in the U.S. have encouraged their members to infiltrate law enforcement agencies. While there are anecdotal examples of insider threats in law enforcement, we do not have a systematic understanding of whether these are isolated incidents or indicative of a more pervasive issue. To address this gap, the current project took a multi-method approach to examining department-level policies and procedures around screening and hiring.

The State of Practice Report is the major deliverable from this grant focused on multi-pronged formative research on insider threats in U.S. law enforcement. Broadly, we were interested in the extent …

Implementation Strategies To Improve Hiv Care Cascade Outcomes In Low- And Middle-Income Countries: A Systematic Review From 2014 To 2021, Sita Lujintanon, Ingrid Eshun-Wilson, Noelle Le Tourneau, Laura Beres, Sheree Schwartz, Stefan Baral, Ryan Thompson, Ashley Underwood, Branson Fox, Elvin H Geng, Christopher G Kemp

2020-Current year OA Pubs

INTRODUCTION: In low- and middle-income countries (LMICs), which are disproportionately affected by the HIV epidemic and manage limited resources, optimized implementation strategies are needed to enhance the efficiency of the HIV response. Assessing strategy usage to date could identify research gaps and inform future implementation efforts. We conducted a systematic review to describe the features and distributions of published implementation strategies attempting to improve HIV treatment service delivery and outcomes.

METHODS: We searched PubMed, Embase, and CINAHL and screened abstracts and full texts published between 1 January 2014 and 27 August 2021, for English-language studies conducted in LMICs that described …

Phase 1b Study To Assess The Safety, Tolerability, And Clinical Activity Of Pamiparib In Combination With Temozolomide In Patients With Locally Advanced Or Metastatic Solid Tumors, Agostina Stradella, Haeseong Park, Et Al.

2020-Current year OA Pubs

BACKGROUND: Pamiparib is a potent, selective, poly (ADP-ribose) polymerase 1/2 inhibitor that demonstrates synthetic lethality in cells with breast cancer susceptibility gene mutations or other homologous recombination deficiency. This two-stage phase 1b study (NCT03150810) assessed pamiparib in combination with temozolomide (TMZ) in adult patients with histologically confirmed locally advanced and metastatic solid tumors.

METHODS: Oral pamiparib 60 mg was administered twice daily. During the dose-escalation stage, increasing doses of TMZ (40-120 mg once daily pulsed or 20-40 mg once daily continuous) were administered to determine the recommended dose to be administered in the dose-expansion stage. The primary objectives were to …

Liver Disease And Transplantation In Telomere Biology Disorders: An International Multicenter Cohort, Yunzu Michele Wang, Steven K Brennan, Sakil Kulkarni, Et Al.

2020-Current year OA Pubs

BACKGROUND: Patients with telomere biology disorders (TBD) develop hepatic disease, including hepatitis, cirrhosis, and hepatopulmonary syndrome. No specific treatment exists for TBD-related liver disease, and the role of liver transplantation (LT) remains controversial. Our study objectives were to describe the clinical characteristics, management, and outcomes in patients with TBD-related liver disease, and their LT outcomes.

METHODS: Data from 83 patients with TBD-associated liver disease were obtained from 17 participating centers in the Clinical Care Consortium of Telomere-Associated Ailments and by self-report for our retrospective, multicenter, international cohort study.

RESULTS: Group A ("Advanced") included 40 patients with advanced liver disease. Of …

Replication And Reliability Of Parkinson's Disease Clinical Subtypes, Therese V Cash, Christina N Lessov-Schlaggar, Erin R Foster, Peter S Myers, Joshua J Jackson, Baijayanta Maiti, Paul T Kotzbauer, Joel S Perlmutter, Meghan C Campbell

2020-Current year OA Pubs

BACKGROUND: We recently identified three distinct Parkinson's disease subtypes: "motor only" (predominant motor deficits with intact cognition and psychiatric function); "psychiatric & motor" (prominent psychiatric symptoms and moderate motor deficits); "cognitive & motor" (cognitive and motor deficits).

OBJECTIVE: We used an independent cohort to replicate and assess reliability of these Parkinson's disease subtypes.

METHODS: We tested our original subtype classification with an independent cohort (N = 100) of Parkinson's disease participants without dementia and the same comprehensive evaluations assessing motor, cognitive, and psychiatric function. Next, we combined the original (N = 162) and replication (N = 100) datasets to test …

Niu Constitution And Bylaws & Fs Bylaws 2024-07-01, Northern Illinois University

University Council Archives

No abstract provided.

Rrh Library Newsletter, Summer 2024, Libraries At Rochester Regional Health

Rochester Regional Health authored publications and proceedings

Newsletter sections include: Database Upgrade: Trip Pro; Update: Nursing Point of Care Tools; NOVELny Databases; Library Website Survey; Don't Pay for Articles!

Gene Expression Networks Regulated By Human Personality, Coral Del Val, Elisa Díaz De La Guardia-Bolívar, Igor Zwir, Pashupati P Mishra, Alberto Mesa, Ramiro Salas, Guillermo F Poblete, Gabriel De Erausquin, Emma Raitoharju, Mika Kähönen, Olli Raitakari, Liisa Keltikangas-Järvinen, Terho Lehtimäki, Claude Robert Cloninger

2020-Current year OA Pubs

Genome-wide association studies of human personality have been carried out, but transcription of the whole genome has not been studied in relation to personality in humans. We collected genome-wide expression profiles of adults to characterize the regulation of expression and function in genes related to human personality. We devised an innovative multi-omic approach to network analysis to identify the key control elements and interactions in multi-modular networks. We identified sets of transcribed genes that were co-expressed in specific brain regions with genes known to be associated with personality. Then we identified the minimum networks for the co-localized genes using bioinformatic …

Alcohol Milestones And Internalizing, Externalizing, And Executive Function: Longitudinal And Polygenic Score Associations, Sarah E Paul, David A A Baranger, Joshua J Jackson, Aaron J Gorelik, Alexander S Hatoum, Michael Strube, Andrey P Anokhin, Arpana Agrawal, Kathleen K Bucholz, Ryan Bogdan, Et Al.

2020-Current year OA Pubs

BACKGROUND: Although the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, the directionality of these associations, specificity to stages of alcohol involvement, and extent of shared genetic liability remain unclear. We estimate longitudinal associations between transitions among alcohol milestones, behavioral phenotypes, and indices of genetic risk.

METHODS: Data came from the Collaborative Study on the Genetics of Alcoholism (

RESULTS: Externalizing phenotypes (e.g. conduct disorder symptoms) were associated with future initiation and drinking problems (hazard ratio (HR)⩾1.16). Internalizing (e.g. social anxiety) was associated with hazards for progression from first drink to severe …

A Personalized Semi-Automatic Sleep Spindle Detection (Psasd) Framework, Mohammadmehdi Kafashan, Gaurang Gupte, Paul Kang, Orlandrea Hyche, Anhthi H Luong, G V Prateek, Yo-El S Ju, Ben Julian A Palanca

2020-Current year OA Pubs

BACKGROUND: Sleep spindles are distinct electroencephalogram (EEG) patterns of brain activity that have been posited to play a critical role in development, learning, and neurological disorders. Manual scoring for sleep spindles is labor-intensive and tedious but could supplement automated algorithms to resolve challenges posed with either approaches alone.

NEW METHODS: A Personalized Semi-Automatic Sleep Spindle Detection (PSASD) framework was developed to combine the strength of automated detection algorithms and visual expertise of human scorers. The underlying model in the PSASD framework assumes a generative model for EEG sleep spindles as oscillatory components, optimized to EEG amplitude, with remaining signals distributed …

A Word From The Writing Team (July 2024), Pam Walter, Mfa

A Word From the Writing Team (Newsletter)

This issue includes:

• Publication Spotlight
• Join Us for Summer Writing Time
• For FY24-25, the Open Access Publishing Fund Process is Changing
• Jefferson has Funding Agreements with Specific Publishers
• The OPWPC Canvas Page Offers Helpful Tools
• Scott Memorial Library Archive Renovations are Done!

Natural Variation In Yeast Reveals Multiple Paths For Acquiring Higher Stress Resistance, Amanda N. Scholes, Tara N. Stuecker, Stephanie E. Hood, Cader J. Locke, Carson L. Stacy, Qingyang Zhang, Jeffrey A. Lewis

Biological Sciences Faculty Publications and Presentations

Background

Organisms frequently experience environmental stresses that occur in predictable patterns and combinations. For wild Saccharomyces cerevisiae yeast growing in natural environments, cells may experience high osmotic stress when they first enter broken fruit, followed by high ethanol levels during fermentation, and then finally high levels of oxidative stress resulting from respiration of ethanol. Yeast have adapted to these patterns by evolving sophisticated “cross protection” mechanisms, where mild ‘primary’ doses of one stress can enhance tolerance to severe doses of a different ‘secondary’ stress. For example, in many yeast strains, mild osmotic or mild ethanol stresses cross protect against severe …

Ai-Assisted Study In Post Pandemic Disruptions Of Operations And Supply Chain Management Practices, Raouf G. Ghattas, Andrew Burnstine

Faculty and Staff Publications & Presentations

The presentation explored the nature of the Fashion Industry group, the disruptions, the impact on the industry as a whole, in terms of Profitability, Consumer preference, Demand, Logistics and Inventory positions, then discuss the mitigations adopted by each industry group, and finally strategies for the way forward.

The presentation explored the nature of the Fashion Industry group, the disruptions, the impact on the industry as a whole, in terms of Profitability, Consumer preference, Demand, Logistics and Inventory positions, then discuss the mitigations adopted by each industry group, and finally strategies for the way forward.

Genetic Correlations Between Liver Fat Content, Metabolic Health, And Adiposity Distribution In The Fels Longitudinal Study, Ariana L. Garza, Miryoung Lee, John Blangero, Cici X. Bauer, Stefan A. Czerwinski, Audrey C. Choh

School of Medicine Publications

Highlights

• Steatosis and all other related phenotypes examined were significantly heritable.

• Liver fat showed significant genetic correlation with various phenotypes.

• The strongest genetic correlation of liver fat was with insulin resistance.

• Glucose homeostasis phenotypes were also genetically correlated to adiposity traits.

Abstract

Background and aims

Hepatic steatosis is known to be heritable, but its genetic basis is mostly uncharacterized. Steatosis is associated with metabolic and adiposity features; recent studies hypothesize that shared genetic effects between these traits could account for some of the unexplained heritability. This study aimed to quantify these genetic associations in a family-based sample of non-Hispanic white …

Adherence To Governance Patterns: How Institutional Work And Knowledge Dissemination Influence The Institutionalization Of Brazilian Industrial Clusters?, Mácio Jacometti, Sandro A. Gonçalves, Leandro Bonfim, Luiz C. Oliveira

Faculty Journal Articles

Purpose – This article examines how the institutional work of inducing agents and the dissemination of knowledge among induced immersed actors have influenced adherence to governance standards in Brazilian industrial clusters.

Theoretical framework – We use institutional theory to frame the relationships between embedded firms through regulatory, normative, and cultural-cognitive pillars and the view of field-level agents engaged in institutional work, who share knowledge to induce adherence to governance standards.

Design/methodology/approach – We adopted a mixed methods research design, examining 96 companies in three Brazilian industrial clusters. We used WABA analysis to test our model within and between clusters using …

Do Sociologists Put Enough Emphasis On The Use Of Available Data In Teaching Research Methods? Observations From A Teacher And A Student, Alexis Rei, Roger Clark

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

Book Review: The Mindful Body: Thinking Our Way To Chronic Health, Michele Hoffnung, Emily Stier Adler

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

Contraceptive Use Among Women Experiencing Intimate Partner Violence And Reproductive Coercion: The Moderating Role Of Ptsd And Depression, Jessica L. Zemlak, Lea Marineau, Tiara C. Willie, Helena Addison, Gabrielle Edwards, Trace S. Kershaw, Kamila A. Alexander

College of Nursing Faculty Research and Publications

Women experiencing reproductive coercion (RC) report more unintended pregnancies and mental health symptoms that can influence contraceptive use patterns. We examined associations between RC and contraceptive use among intimate partner violence (IPV) exposed women aged 18–35 (N = 283). We tested depression, post-traumatic stress disorder (PTSD), and co-morbid depression and PTSD as effect modifiers. Though no association was found between RC and contraception, PTSD significantly modified this relationship. Among Black women (n = 112), those reporting RC and either PTSD or comorbid PTSD and depression were less likely to use partner-independent contraception compared to those reporting RC without …