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Resting State Electroencephalographic Brain Activity In Neonates Can Predict Age And Is Indicative Of Neurodevelopmental Outcome, Amir Ansari, Kirubin Pillay, Emad Arasteh, Anneleen Dereymaeker, Gabriela Schmidt Mellado, Katrien Jansen, Anderson M. Winkler, Gunnar Naulaers, Aomesh Bhatt, Sabine Van Huffel

School of Medicine Publications

Objective: Electroencephalography (EEG) can be used to estimate neonates' biological brain age. Discrepancies between postmenstrual age and brain age, termed the brain age gap, can potentially quantify maturational deviation. Existing brain age EEG models are not well suited to clinical cot-side use for estimating neonates' brain age gap due to their dependency on relatively large data and pre-processing requirements.

Methods: We trained a deep learning model on resting state EEG data from preterm neonates with normal neurodevelopmental Bayley Scale of Infant and Toddler Development (BSID) outcomes, using substantially reduced data requirements. We subsequently tested this model in two independent datasets …

Development And Validation Of A Plasmalogen Score As An Independent Modifiable Marker Of Metabolic Health: Population Based Observational Studies And A Placebo-Controlled Cross-Over Study, Habtamu B. Beyene, Kevin Huynh, Tingting Wang, Sudip Paul, Michelle Cinel, Natalie A. Mellett, Gavriel Olshansky, Thomas G. Meikle, Gerald F. Watts, John Blangero

School of Medicine Publications

Background

Decreased levels of circulating ethanolamine plasmalogens [PE(P)], and a concurrent increase in phosphatidylethanolamine (PE) are consistently reported in various cardiometabolic conditions. Here we devised, a plasmalogen score (Pls Score) that mirrors a metabolic signal that encompasses the levels of PE(P) and PE and captures the natural variation in circulating plasmalogens and perturbations in their metabolism associated with disease, diet, and lifestyle.

Methods

We utilised, plasma lipidomes from the Australian Obesity, Diabetes and Lifestyle study (AusDiab; n = 10,339, 55% women) a nationwide cohort, to devise the Pls Score and validated this in the Busselton Health Study (BHS; n = …

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After Sars-Cov-2 Infection, Elizabeth R. Unger, Jin-Mann S. Lin, Lauren E. Wisk, Huihui Yu, Michelle L'Hommedieu, Helen Lavretsky, Juan Carlos C. Montoy, Michael A. Gottlieb, Kristin L. Rising, Nicole L. Gentile, Michelle Santangelo, Arjun K. Venkatesh, Robert M. Rodriguez, Mandy J. Hill, Rachel E. Geyer, Efrat R. Kean, Sharon Saydah, Samuel A. Mcdonald, Ryan Huebinger, Ahamed H. Idris, Jocelyn Dorney, Bala Hota, Erica S. Spatz, Kari A. Stephens, Robert A. Weinstein, Joann G. Elmore

Department of Emergency Medicine Faculty Papers

IMPORTANCE: Chronic symptoms reported following an infection with SARS-CoV-2, such as cognitive problems, overlap with symptoms included in the definition of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

OBJECTIVE: To evaluate the prevalence of ME/CFS-like illness subsequent to acute SARS-CoV-2 infection, changes in ME/CFS symptoms through 12 months of follow-up, and the association of ME/CFS symptoms with SARS-CoV-2 test results at the acute infection-like index illness.

DESIGN, SETTING, AND PARTICIPANTS: This prospective, multisite, longitudinal cohort study (Innovative Support for Patients with SARS-CoV-2 Infections Registry [INSPIRE]) enrolled participants from December 11, 2020, to August 29, 2022. Participants were adults aged 18 to 64 …

Understanding Differential Reductions In Undernutrition Among Districts In Rwanda Through The Perspectives Of Mid-Level And Community Actors On Policy Commitment And Policy Coherence, Elyse Iruhiriye, Edward A. Frongillo Ph.D., Deanna K. Olney, Emmanuel Niyongira, Simeon Nanama, Christine E. Blake Ph.D., Rd, Eugene Rwibasira, Paul Mbonyi

Faculty Publications

Understanding the drivers of improvements in child undernutrition at only the national level can mask subnational differences. This paper aimed to understand the contributions of factors in the enabling environment to observed differences in stunting reduction between districts in Rwanda. In 2017, we conducted 58 semi-structured interviews with mid-level actors (n = 38) and frontline workers (n = 20) implementing Rwanda's multi-sectoral nutrition policy in five districts in which stunting decreased (reduced districts) and five where it increased or stagnated (non-reduced districts) based on Rwanda's 2010 and 2014/15 Demographic and Health Surveys. Mid-level actors are government officials and service providers …

Causes And Consequences Of Mitotic Chromosome Missegregation In Human Pluripotent Stem Cells, Chenhui Deng

Dartmouth College Ph.D Dissertations

Mitosis is a fundamental process that ensures the equal distribution of replicated chromosomes, which carry an organism's genetic material, into two daughter cells. The fidelity of mitosis is paramount, as errors in chromosome segregation result in aberrant chromosome numbers, including gains or losses, a state termed aneuploidy. Aneuploidy impacts a broad range of human conditions, including being one of the major hurdles in early human development where it is the primary cause of miscarriages and birth defects. Strikingly, more than 70% of human preimplantation embryos are aneuploid with mitotic chromosome segregation errors being the most common source of aneuploidy. However, …

Gaze In Context: Individual And Group Differences In Real-World Visual Attention, Amanda J. Haskins

Dartmouth College Ph.D Dissertations

When exploring a real-world scene, individuals direct their gaze to selectively attend, leaving a trace of their informational priorities. What drives this information selection, and what causes individuals to prioritize information differently from one another? In this dissertation, I aim to understand the influences that guide visual attention as individuals explore real-world environments and to characterize patterns of visual attention that differ among individuals and among groups with neurodevelopmental conditions. In Chapter 1, I introduce a novel eyetracking paradigm, in which participants can actively explore immersive, naturalistic scene photospheres via headmounted virtual reality. Using this paradigm, I demonstrate that naturalistic …

Endovascular Versus Medical Therapy In Posterior Cerebral Artery Stroke: Role Of Baseline Nihss Score And Occlusion Site, Italo Linfante, Guilherme Dabus

All Publications

Background: Acute ischemic stroke with isolated posterior cerebral artery occlusion (iPCAO) lacks management evidence from randomized trials. We aimed to evaluate whether the association between endovascular treatment (EVT) and outcomes in iPCAO acute ischemic stroke is modified by initial stroke severity (baseline National Institutes of Health Stroke Scale [NIHSS]) and arterial occlusion site.

Methods: Based on the multicenter, retrospective, case-control study of consecutive iPCAO acute ischemic stroke patients (PLATO study [Posterior Cerebral Artery Occlusion Stroke]), we assessed the heterogeneity of EVT outcomes compared with medical management (MM) for iPCAO, according to baseline NIHSS score (≤6 versus >6) and occlusion site …

Assessing The Knowledge And Awareness Of Us Oncologists Regarding The Specialty Of Oral Medicine, Alessandro Villa

All Publications

Objectives: This cross-sectional study aimed to assess the awareness among United States (US) oncologists about oral medicine (OM) as a specialty of dentistry, and their collaboration with OM providers.

Methods: An online survey was conducted, inviting 1350 US oncologists, with data collected on demographics, practice background, comfort level with diagnosing and treating oral conditions, referral practices for oral conditions, and more.

Results: Of the invited 1350 oncologists, 192 responded (14% response rate). Among respondents, 46% were familiar with the OM specialty. Of these, 73% had previously sought consultation from OM specialists. The primary reasons for referral included dental clearance before …

Smokejumper Magazine, July 2024, National Smokejumper Association

Smokejumper and Static Line Magazines

This issue of the National Smokejumper Association (NSA) Smokejumper Magazine, contains the following articles: Message from the President; A Tribute to a Smokejumper; Down the Yukon Alone; North Cascades Pararescue Operations, 1957-1989; What Happened to America's Middle Class?; How Bobby Montoya Saved My Life; GAC Goats; The Burning of Ruth; Gone But Not Forgotten: South Canyon Fire; Just Keep Them From Burning the Place Down; Remembrances; The Failures of Fire, Law Enforcement, and Other Agencies at the Lahaina, Maui, Fire; Sounding Off; Blazing A New Trail; Reflections on Wildland Firefighting; Odds and Ends; Notes from the Ranks; May 1981 Redding …

Increased Co2 Levels During The First Half Of Incubation At High Altitude Modifies Embryonic Development Of Fertile Leghorn Breeder Eggs, Marco A. Juarez-Estrada, Erik I. Lopez-Ruiz, Sonia Lopez-Cordova, G. Tellez-Isaias, Omar F. Prado-Rebolledo

Political Science Faculty Publications and Presentations

The exchange of oxygen (O₂) and carbon dioxide (CO₂) within an incubator has a significant impact on embryonic development (ED) and hatching processes. This study examines the influence of non-ventilation (NV) conditions during the first ten days of incubation at high altitudes on Leghorn hens hatching eggs. Five hundred four hatching eggs were equally divided into three treatment groups and placed in twelve incubators (R = 4). The first group was subjected to standard ventilated conditions (V) during the setting phase. The ventilation inlet holes of the remaining incubators in the NV treatments were closed with …

Green Bond Premiums In The Asia-Pacific And European Markets, Parath Wongaree, Chiyachantana N. Chiraphol, Kuan Yong David Ding, Wasin Siwasarit

Research Collection Lee Kong Chian School Of Business

We examine green bond premiums in the primary and secondary bond markets in the Asia-Pacific and Europe. In both regions, green bond yields are significantly lower than those of conventional bonds in the primary market, indicating that a green bond premium exists. Asia-Pacific investors in the secondary market are more willing to accept lower yields than European ones. We find that green bonds have a lower risk than conventional bonds. Investment grade issuers, financial sector issuers, and local currency green bonds are associated with lower yields due to their stronger reputation, higher credit ratings, and absence of foreign exchange risk.

Competing With The Platform: Complementor Positioning And Cross-Platform Response To Entry, Aldona Kapacinskaite, Ahmadreza Mostajabi

Research Collection Lee Kong Chian School Of Business

Research SummaryThis study contrasts traditional entry dynamics with platform owner entry into a complementor market and examines cross-platform complementor response to competition with the platform. Generalists experience low repositioning cost and are more likely to shift effort away, while specialists focus their effort on the focal platform. We examine Apple's “Files” app entry and find support for our hypotheses: generalists shift effort toward the competing platform, while specialists double down on the focal platform. Moreover, empirically comparing Apple's entry with that of other large firms, we find that only the platform owner elicits a strong complementor response. This article contributes …

Smokejumper Obituary: Clithero, Robert M. “Bob” (Missoula 1959), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Independent Associations With Early Mortality After Open Repair Of Crawford Extent Iv Thoracoabdominal Aortic Aneurysms, Hiruni S Amarasekara, Marc R Moon, Scott A Lemaire, Joseph S Coselli

Faculty, Staff and Students Publications

Objective: We aimed to identify outcomes and factors that independently associate with early mortality after open repair of Crawford extent IV thoracoabdominal aortic aneurysms, defined as aneurysms confined to the segment below the diaphragm.

Methods: This retrospective analysis included 721 extent IV thoracoabdominal aortic aneurysm repairs performed in our institution from 1986 to 2021. Indications for repair were aneurysm without dissection in 627 cases (87.0%) and aortic dissection in 94 cases (13.0%). Overall, 466 patients (64.6%) were symptomatic preoperatively; 124 (17.2%) procedures were performed in patients with acute presentation, including 58 (8.0%) ruptured aneurysms.

Results: Operative death occurred after 49 …

Plozasiran (Aro-Apoc3) For Severe Hypertriglyceridemia: The Shasta-2 Randomized Clinical Trial, Stephen J Nicholls, Robert S Rosenson, Karen Modesto, Javier San Martin, Jennifer Hellawell, Christie M Ballantyne

Faculty, Staff and Students Publications

Importance: Severe hypertriglyceridemia (sHTG) confers increased risk of atherosclerotic cardiovascular disease (ASCVD), nonalcoholic steatohepatitis, and acute pancreatitis. Despite available treatments, persistent ASCVD and acute pancreatitis-associated morbidity from sHTG remains.

Objective: To determine the tolerability, efficacy, and dose of plozasiran, an APOC3-targeted small interfering-RNA (siRNA) drug, for lowering triglyceride and apolipoprotein C3 (APOC3, regulator of triglyceride metabolism) levels and evaluate its effects on other lipid parameters in patients with sHTG.

Design, setting, and participants: The Study to Evaluate ARO-APOC3 in Adults With Severe Hypertriglyceridemia (SHASTA-2) was a placebo-controlled, double-blind, dose-ranging, phase 2b randomized clinical trial enrolling adults with sHTG at 74 …

Smile Brighter, Michigan: Inside The Mda Public Education Campaign, Rich Evans

The Journal of the Michigan Dental Association

The Michigan Dental Association's (MDA) Public Education Campaign, active for over three decades, aims to improve oral health and encourage visits to MDA-member dentists across Michigan. Funded by member dues, the campaign uses digital advertising and the smilemichigan.com website to educate the public. Key initiatives include the Find-A-Dentist tool, the "Healthy Mouth, Healthy Body" program, and various community outreach efforts. Upcoming features include the "Story Behind Every Smile" campaign, highlighting personal stories about the impact of dental health. By promoting proactive oral care, the MDA supports better overall health for Michigan residents.

Look To Your Ada, Mda For Health, And Wellness Help, Michelle C. Dziurgot Dds

The Journal of the Michigan Dental Association

This month, MDA Journal Editor Michelle C. Dziurgot, DDS, highlights dentists' mental health challenges, emphasizing the support available through the ADA and MDA. She references a 2021 survey showing high depression rates among dentists and lists depression symptoms. The ADA provides resources and a confidential health and wellness program. Similarly, the MDA offers the Member Assistance Program with counseling services for dentists and their families. Dziurgot urges dentists to seek help and not ignore their feelings, noting the persistent stress from the pandemic and the importance of utilizing available support.

The Mda Forensic Dental Team Needs More Volunteers, Patrick Houlihan Dds

The Journal of the Michigan Dental Association

The Michigan Dental Association Forensic Dental Identification Team (MDA-FDIT) urgently needs more volunteers. In this article, learn of their impressive record of service to the public and the profession, which has been widely recognized for the important role it plays in the identification of both individual victims and those of mass disasters. Formed in the early 1980s, MDA-FDIT plays a crucial role in identifying disaster victims using dental records. The team has been instrumental in identifying victims from incidents like the 1987 Northwest Flight 255 crash and has assisted in various mass-casualty situations, including 9/11 and Hurricane Katrina. MDA-FDIT works …

Dentistry And The Law: Unpaid Internships In Your Office: What You Should Know, Daniel Schulte Jd

The Journal of the Michigan Dental Association

A reprint of a previous Journal column, Mr. Schulte discusses how unpaid internships require careful legal consideration. Interns must primarily benefit educationally from their tasks to avoid being classified as employees, necessitating compensation. Office work typically performed by employees must not be assigned to interns. Patient consent is required to observe dental procedures, and interns must receive HIPAA training. Exposure to hazardous materials should be avoided, adhering to laws like Michigan’s Occupational Safety and Health Act. Proper training and task limitations ensure compliance and a beneficial internship experience.

The New Professional: The Important Role Of Organized Dentistry In Early Career Success, Amrita Patel Dds

The Journal of the Michigan Dental Association

As a new dentist, navigating the professional world requires more than clinical skills; involvement in organized dentistry is crucial. It fosters personal and professional growth, provides continuous learning through seminars and workshops, and offers networking and mentorship opportunities. Additionally, it serves as a collective voice advocating for the profession’s interests, influencing policies, and fostering leadership development. Membership grants access to practice resources and support services, helping new dentists navigate challenges and build successful careers. Ultimately, organized dentistry creates a supportive community, essential for early career success.

J Mich Dent Assoc July 2024

The Journal of the Michigan Dental Association

Every month, the Journal of the Michigan Dental Association provides news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. It is the primary publication reaching Michigan dentists.

The July issue of the Michigan Dental Association (MDA) journal focuses on the member and public value of the association's Public Education Campaign through a cover story "Smile Brighter Michigan!". It also features articles on:

• How to get value from your MDA membership

• Joining the MDA Forensic Dental Team

• A new professional column, News you need, an editorial and regular department articles covering MDA …

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Mda Services: Five Tips To Recruit, Retain Good Employees, Reva Darling

The Journal of the Michigan Dental Association

In a competitive labor market, retaining and recruiting dental staff is challenging. Key strategies include offering health insurance, pre-tax benefit options, and retirement plans, which attract long-term employees. Providing vision insurance and discounts on auto and home insurance can further enhance employee satisfaction. Updating pay scales and utilizing temporary services like Stynt can also aid in filling staff positions.

Reimagining Utopia In Post-Utopian China: Chinese Science Fiction And The Reinvention Of Cultural Tradition, Dan Luo

Theses and Dissertations

Despite the end of China’s socialist dream in the late 1970s, utopian expressions about the nation’s rise and progress have continued to emerge in official and popular imaginaries. These expressions find an outlet in the newly popularized sci-fi genre, and especially in literary experiments that evoke cultural resources ranging from premodern and early modern historical and literary records of scientific achievements to figures, tropes, and myths in classical tales, vernacular novels, and ethnic traditions. These experiments at times validate and support, and at times challenge and subvert the nationalist, progressive, and utopian narratives of the state. This dissertation investigates the …

Sexual Quality Of Life In Sexual And Gender Minority Women After Cancer, Heather Schneider Miles

Theses and Dissertations

Sexual quality of life (SQoL) is a critical aspect of well-being, encompassing physical, emotional, and social dimensions. For sexual and gender minority women (SGMW)—lesbian, bisexual, transgender, or queer—cancer presents unique challenges. This dissertation examined the relationships between cancer treatment symptoms, social support, and communication with the cancer care team (CCT) on SQoL among SGMW survivors of breast, gynecological, and colorectal cancers. Quantitative data from 37 participants were collected using PROMIS® measures, assessing demographics, treatment history, post-treatment symptoms, perceived social support, and communication with the CCT. Additionally, in-depth interviews with five participants provided qualitative insights into their experiences and the meaning …

Trust In Governance System (Tgs) In The Hotel Context: Scale Development And Validation, Swechchha Subedi

Theses and Dissertations

The purpose of this study was to conceptualize trust in governance systems (TGS) within the hotel context, develop a scale to measure it, and validate its effects on hotel investment decisions. The study focused on the perspectives of hotel leadership which includes the owners, operators, and investors in the United States. The study employed a mixed-methods approach, exploratory sequential research design. Initially, the governance system within the hotel industry was conceptualized, and trust in governance was defined. The scale development phase involved generating items and dimensions through literature review, expert review, and pilot testing. The final scale included multiple dimensions …

Centralized Finance And Decentralized Finance, Leili Pour Rostami

Theses and Dissertations

This dissertation explores different facets of financial markets, focusing on the interplay between decentralized finance, traditional banking systems, and private market relationship lending. By examining these diverse areas, we aim to provide a comprehensive understanding of how emerging financial instruments and market behaviors interact with traditional financial systems. Decentralized Finance (DeFi) offers an escape from the challenges of centralized finance (CeFi). The first essay explores whether and how returns on DeFi instruments, particularly cryptocurrencies, manage to evade the traditional “rules” in response to exogenous central bank monetary policy shocks. The findings reveal that crypto abnormal returns decline significantly with shocks, …

Accessory Eyes And Dynamic Color Change In Palaemon Vulgaris, Nicholas Raymond Steichmann

Theses and Dissertations

Eyes are physiologically costly organs to produce and maintain, making the development of secondary eyes intriguing. Caridean shrimp possess reflecting superposition primary eyes, but some species across fourteen families possess an additional pair of eyes called accessory eyes along the dorso-posterior margin of the primary eyes. Secondary eyes are found in lizards, lampreys, and insects, where they often function as illumination detectors. Some shrimps may use accessory eyes to signal endocrine organs in their eyestalks to alter the pigmentation of their carapace providing better camouflage through disruptive coloration. To investigate the role of accessory eyes in dynamic color change we …

Saved By Naloxone: The Path To Sobriety?, Marli Rose-Firillo Fichtner

Theses and Dissertations

Beginning in the early 2000s, lawmakers sought to mitigate harm and reduce mortality rates by enacting various policies and increasing community outreach, such as educating society about the dangers of opioids. These efforts can be divided into two broad categories: Drug use prevention and harm reduction. Research has been conducted on both of these strategies, utilizing retrospective analysis on outcomes including crime and mortality, among others. It is of great interest to understand which policies are most effective. NALs are an example of harm reduction because they reverse overdoses should they occur. Preemptive naloxone distribution reduces the likelihood of fatal …

Leaf Development In The Reproductive Phase Of Arabidopsis: Investigating The Mechanics Of Cauline Leaf Identity And Bract Suppression, Darren Paul Manuela

Theses and Dissertations

Leaves in the reproductive phase subtend inflorescences or flowers and exhibit diverse morphological modifications specialized for reproductive success, such as attracting pollinators, protecting flowers/fruit, and photosynthesis. Using the model organism Arabidopsis, we investigated the development of these specialized leaves. In Arabidopsis, uniquely shaped cauline leaves subtend inflorescences, protect young floral buds and exhibit increased photosynthetic activity crucial for seed production. As form affects function, we analyzed gene expression patterns by RT-qPCR and GUS reporter genes in cauline leaves and examined mutant phenotypes with defective cauline leaf morphology. Our results reveal that redundant miR156-targeted SPLs function to promote cauline leaf identity …

Scenic Design: Learning How To Think Outside The Black Box, Ashley Jensen

Theses and Dissertations

During my time in the scenic design MFA program at the University of South Carolina, the most important thing I learned is how little I knew before starting this journey. This thesis will explore the challenges I faced and the growth I experienced through the pain of it all. I will demonstrate what I learned by going through each design process step-by-step, and how I became a better artist for it.