Digital Commons Network^™

Study On Factors Influencing The Strong Chromatic Index Of Graphs Derived From Path Graphs, Star Graphs, And Cycle Graphs, Vikram St

Theses and Dissertations

Graph coloring is a major research area in Graph Theory that has a rich collection of research articles contributed by mathematicians across the world. This thesis focuses on a specific type of Graph coloring where the edges of a graph are colored by a principle called strong edge-coloring. There have been numerous research articles published on the least number of colors required to define such a coloring for a given graph G. This least number, χ′s (G), is called as the strong chromatic index of a graph G. Though conjectures stated as early as 1989 remain unsolved, there have been …

What Constitutes Adequate Control Of High Blood Pressure? Current Considerations, Donald E. Casey, Alexander J. Blood, Stephen D. Persell, Daniel Pohlman, Jeff D. Williamson

College of Population Health Faculty Papers

An estimated 45% of adult Americans currently have high blood pressure (HBP). Effective blood pressure (BP) control is essential for preventing major adverse events from cardiovascular and other vascular-related diseases, such as chronic kidney disease, stroke and dementia. A large and growing number of medical professional societies, health care organizations, and governmental agencies have now endorsed a clinical practice guideline-based target for adequate control of HBP to a systolic BP of less than 130 mm Hg. However, adequate BP control to this goal has been recently estimated to be as low as 30%. The first and most important steps to …

Internal Structure Of Incipient Soot From Acetylene Pyrolysis Obtained Via Molecular Dynamics Simulations, Khaled Mosharraf Mukut, Anindya Ganguly, Eirini Goudeli, Georgios Kelesidis, Somesh P. Roy

Mechanical Engineering Faculty Research and Publications

A series of reactive molecular dynamics simulations is used to study the internal structure of incipient soot particles obtained from acetylene pyrolysis. The simulations were performed using the ReaxFF potential at four different temperatures. The resulting soot particles are cataloged and analyzed to obtain statistics of their mass, volume, density, C/H ratio, number of cyclic structures, and other features. A total of 3324 incipient soot particles were analyzed in this study. Based on their structural characteristics, the incipient soot particles are classified into two classes, termed type 1 and type 2 incipient soot particles in this work. The radial distribution …

Development And Validation Of A Measure For Seeking Health Information In The Diabetes Online Community: Mixed Methods Study, Allyson S. Hughes, Sarah Beach, Spruhaa Vasistha, Nazanin M. Heydarian, Osvaldo F. Morera

School of Social Work Faculty Publications

Background

Individuals with chronic diseases often search for health information online. The Diabetes Online Community (DOC) is an active community with members who exchange health information; however, few studies have examined health information brokering in the DOC.

Objective

The aim of this study was to develop and validate the Attitudes Toward Seeking Health Information Online (ATSHIO) scale in a sample of adults with type 1 diabetes (T1D).

Methods

People with T1D were recruited through the DOC, specifically Facebook and Twitter. They were provided with a Qualtrics link to complete the survey. This was a mixed methods study that used thematic …

Urban-Rural Disparities In Food Insecurity And Weight Status Among Children In The United States, Jayna M Dave, Tzuan A Chen, Alexandra N Castro, Mamie A White, Elizabeth A Onugha, Sloane Zimmerman, Debbe Thompson

Children’s Nutrition Research Center Staff Publications

Place of residence (urban versus rural) is a contextual determinant of health that has received less attention in the food insecurity literature. The purpose of this study was to assess the urban–rural disparity in the prevalence of food insecurity and weight status among US children. Using data from the National Health and Nutrition Examination Survey (NHANES) 2013–2016 with three age groups of children (2–5, 6–11, and 12–17 years old), the associations of weight status and child and household food security status by urban–rural residence were examined using Rao–Scott Chi-square tests. Statistical significance was set at p < 0.05. Children living in urban areas were significantly more likely to experience household food insecurity (29.15%) compared to their rural counterparts (19.10%), among those aged 6–11 years. The associations between children’s weight status and child and household food security status were significant for children living in urban areas overall and different age groups but not for children living in rural areas. These trends were more pronounced in older age groups. Given the link between food insecurity and higher obesity rates, particularly among urban children, this study highlights the importance of incorporating food security interventions into future obesity prevention programs.

A Review Of Computational Fluid Dynamics Approaches Used To Investigate Lubrication Of Rolling Element Bearings, Farshid Sadeghi, Ujjawal Arya, Saeed Aamer, Andreas Meinel

School of Mechanical Engineering Faculty Publications

Optimizing bearing performance is based on effective lubrication, especially in high-speed machinery, where minimizing churning and drag losses is of significant importance. Over the past few decades, extensive research has been conducted into the better understanding of different aspects of bearing lubrication. These investigations have employed a combination of experimental methods and advanced computational fluid dynamics (CFD) models. This article provides a comprehensive overview of critical aspects of bearing lubrication, with a specific emphasis on recent advances in CFD models. Lubricant flow and distribution patterns are discussed while examining their impact on drag and churning losses. An extensive discussion is …

Effects Of Delay On Short-And Long-Term False Memories For Semantic And Phonological Lists, Ece Yuksel

Theses and Dissertations

The Deese/Roediger-McDermott (DRM) paradigm was developed to investigate false memory using lists of words related to an associated, non-present lure. The purpose of the present study was to examine the differences in memory errors for semantic and phonological lists across delays using the DRM paradigm. Previous studies have shown that the higher rates of false memories for semantic than phonological lists typically seen at longer delays is reversed for very short delays (McBride et al., 2019). Delays of 750 ms, 60 s, 90 s, and 2 min, were included to examine the false memory error rates in semantic and phonological …

A Wrong Made Right: A Qualitative Cross-Case Comparison Study Examining Program Influences On College Readiness, Persistence, And Student Success Outcomes At A Predominantly White University And Historically Black College, Richard Harper

Theses and Dissertations

The increase of underprepared students entering college decreases persistence and graduation rates at postsecondary institutions, ultimately declining degree attainment and social mobility of American citizens (U.S. Department of Education, 2016, McGuire, 2018). ACT, Inc. (2017) data suggests that overwhelming percentages of high school graduates are academically underprepared and are not college-ready. Moreover, an overwhelming number of academically underprepared students come from historically underrepresented populations. To help increase access and college readiness among these populations, specialized programs and services must be implemented to ensure these students are successful at the college level. The Dr. Charles W. Donaldson Scholars Academy is a …

Oral Sebetralstat For On-Demand Treatment Of Hereditary Angioedema Attacks, Marc A Riedl, H James Wedner, Et Al.

2020-Current year OA Pubs

BACKGROUND: Approved on-demand treatments for hereditary angioedema attacks need to be administered parenterally, a route of administration that is associated with delays in treatment or withholding of therapy.

METHODS: In this phase 3, double-blind, three-way crossover trial, we randomly assigned participants at least 12 years of age with type 1 or type 2 hereditary angioedema to take up to two oral doses of sebetralstat (300 mg or 600 mg) or placebo for an angioedema attack. The primary end point, assessed in a time-to-event analysis, was the beginning of symptom relief, defined as a rating of "a little better" on the …

Caregiver Recruitment Strategies For Interventions Designed To Optimize Transitions From Hospital To Home: Lessons From A Randomized Trial, Diane E Holland, Catherine E Vanderboom, Jay Mandrekar, William S Harmsen, Brystana G Kaufman, Cory Ingram, Joan M Griffin

Faculty, Staff and Students Publications

Challenges to recruitment of family caregivers exist and are amplified when consent must occur in the context of chaotic healthcare circumstances, such as the transition from hospital to home. The onset of the COVID-19 pandemic during our randomized controlled trial provided an opportunity for a natural experiment exploring and examining different consent processes for caregiver recruitment. The purpose of this publication is to describe different recruitment processes (in-person versus virtual) and compare diversity in recruitment rates in the context of a care recipient's hospitalization. We found rates of family caregiver recruitment for in-person versus virtual were 28% and 23%, respectively …

Evaluating The Quality Of Serial Em Sections With Deep Learning, Mahsa Bank Tavakoli, Josh L Morgan

2020-Current year OA Pubs

Automated image acquisition can significantly improve the throughput of serial section scanning electron microscopy (ssSEM). However, image quality can vary from image to image depending on autofocusing and beam stigmation. Automatically evaluating the quality of images is, therefore, important for efficiently generating high-quality serial section scanning electron microscopy (ssSEM) datasets. We tested several convolutional neural networks for their ability to reproduce user-generated evaluations of ssSEM image quality. We found that a modification of ResNet-50 that we term quality evaluation Network (QEN) reliably predicts user-generated quality scores. Running QEN in parallel to ssSEM image acquisition therefore allows users to quickly identify …

Development Of A Group-Based Behaviour Change Intervention For People With Severe Obesity Informed By The Social Identity Approach To Health, The Progroup Team, Shokraneh Moghadam, Laura Hollands, Raff Calitri, Dawn Swancutt, Jenny Lloyd, Lily Hawkins, Rod Sheaff, Sarah Dean, Steve Perry, Ross Watkins, Jonathan Pinkney, Mark Tarrant

Peninsula Medical School

Introduction: Interventions to support behaviour change in people living with chronic health conditions increasingly use patient groups as the mode of delivery, but these are often designed without consideration of the group processes that can shape intervention outcomes. This article outlines a new approach to designing group-based behaviour change interventions that prioritizes recipients' shared social identity as group members in facilitating the adoption of established behaviour change techniques (BCTs). The approach is illustrated through an example drawn from research focused on people living with severe obesity. Methods: A prioritization process was undertaken in collaboration with stakeholders, including behaviour change experts, …

Context-Dependent T-Box Transcription Factor Family: From Biology To Targeted Therapy, Zerui Zhang, Junqing Jiang, Dian Hu, Jiaqian Zhang, Zhangfan Wu, Yufei Wang, Wenjie Huang, Limin Xia

Faculty, Staff and Student Publications

T-BOX factors belong to an evolutionarily conserved family of transcription factors. T-BOX factors not only play key roles in growth and development but are also involved in immunity, cancer initiation, and progression. Moreover, the same T-BOX molecule exhibits different or even opposite effects in various developmental processes and tumor microenvironments. Understanding the multiple roles of context-dependent T-BOX factors in malignancies is vital for uncovering the potential of T-BOX-targeted cancer therapy. We summarize the physiological roles of T-BOX factors in different developmental processes and their pathological roles observed when their expression is dysregulated. We also discuss their regulatory roles in tumor …

Proton Magnetic Resonance Spectroscopy (1h-Mrs) As A Potential Tool To Predict Overall Survival In Diffuse Midline Glioma, Esther L. Pavao

Electronic Theses and Dissertations Archive

Proton magnetic resonance spectroscopy (1H-MRS) offers a reliable clinically feasible tool for non-invasive monitoring of tumor metabolism. However, methods for analyzing tumor metabolism using 1H-MRS often lack standardization and rely heavily on manual data processing. This study used 1H-MRS to non-invasively quantify tumor metabolites associated with dysregulated metabolic pathways in patients diagnosed with diffuse intrinsic pontine glioma (DIPG). 1H-MRS technique allowed for the identification of specific metabolic alterations to DIPG that could potentially offer insights into disease progression and therapeutic targets. Utilizing advanced biomedical engineering tools and techniques, we calculated median overall survival lengths at specific metabolic thresholds. The analysis …

Examining The Regulation Of Traf4 In Extraembryonic Stem Cells And Tissues, Hannah Alexis Nelson-Lannom

Electronic Theses and Dissertations Archive

Mitogen-activated protein kinase kinase kinase 4 (MAP3K4) promotes fetal and placental growth by regulating growth-promoting pathways. Mice lacking MAP3K4 kinase activity exhibit placental insufficiency and fetal growth restriction. Upstream pathways activating MAP3K4 may represent key mechanisms to induce growth. We have previously shown that the MAP3K4 binding partner tumor necrosis factor receptor-associated factor 4 (TRAF4) promotes MAP3K4 activity in the embryo. However, the role of TRAF4 and its association with MAP3K4 in the placenta is unknown. Our analysis of single-cell RNA-Seq data showed that Traf4 is one of the most abundant Trafs in the mouse placenta and is coexpressed with …

2024 July 4 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Comorbidity Of Disordered Eating And Depression: Examining Intersectional Inequities And Cardiometabolic Health Consequences Across The Life Course, Franklin Hunter Mcguire

Brown School Graduate Student Theses and Dissertations

Traditional epidemiologic research has often neglected the degree to which interlocking systems of oppression may (1) describe the distribution of population health inequities and (2) moderate health exposure-outcome associations. Grounded in an intersectional framework, this three-aim dissertation used an intersectional multilevel modeling approach (i.e., intersectional MAIHDA) and US nationally representative data to answer a series of intersectionality-informed research questions relevant to disordered eating, depression, and cardiometabolic health. With data from the National Health and Nutrition Examination Survey, Aim 1 quantified the population distribution of weight loss-oriented disordered eating behaviors (DEBs) among US adults across intersectional groups defined by race/ethnicity, sex/gender, …

How Household Economic Stress Matters: Family Functioning And Child Externalizing And Internalizing Behaviors, Jun-Hong Chen

Brown School Graduate Student Theses and Dissertations

This dissertation investigates the multifaceted dynamics of long-term economic stress and its association with subsequent caregiver psychological well-being and children's internalizing and externalizing behaviors. For a comprehensive measure of household economic stress, this dissertation delves into the severity, duration, and fluctuation of economic stress, considering diverse income and asset profiles. The research framework utilizes and integrates a range of existing theories to create a context for understanding the intricate interplay between economic stress, caregiver mental health, and children's behavioral outcomes. Data are drawn from the Panel Study of Income Dynamics, which includes both information about household economic stress and child …

Muscle Weakness And Mitochondrial Stress Occur Before Severe Metastasis In A Novel Mouse Model Of Ovarian Cancer Cachexia, Luca J. Delfinis, Leslie M. Olgilvie, Shahrzad Khajehzadehshoushtar, Shivam Ghandi, Madison C. Garabotti, Arshdeep K. Thuhan, Kathy Matuszewska, Madison Pereira, Ronald G. Jones Iii, Arthur J. Cheng, Thomas J. Hawke, Nicholas P. Greene, Kevin Murach, Jeremy A. Simpson, Jim Petrick, Christopher G.R. Perrry

Health, Human Performance and Recreation Faculty Publications and Presentations

Objectives

Methods

Intersectional Analysis Of Vaccination Inequity Among Individuals With Disabilities In The United States During Covid-19 Pandemic, Philip Ndoki Ndoki

Walden Dissertations and Doctoral Studies

This study was an investigation of how disability status, types, sociodemographic indicators, and reasons for not receiving vaccinations influenced COVID-19 vaccination rates among individuals with disabilities in the United States. Despite efforts, vaccination disparities persisted, necessitating an understanding of barriers to uptake. Using intersectionality theory and the social determinants of health framework, this study examined the impact of marginalized identities and structural inequalities. Key questions included the association between disability status and vaccination uptake, differences among disability types moderated by sociodemographic factors, and the interaction between disability status and reasons for not vaccinating. Household Pulse Survey data from the US …

Machine Learning-Guided Design Of Nanolubricants For Minimizing Energy Loss In Mechanical Systems, Kollol Sarker Jogesh, Md. Aliahsan Bappy

Mechanical Engineering Faculty Publications

This study explores the significant potential of machine learningguided design in optimizing nanolubricants, focusing on their application in reducing friction and wear in mechanical systems. Utilizing neural networks and genetic algorithms, the research demonstrates how advanced computational techniques can accurately predict and enhance the tribological properties of nanolubricants. The findings reveal that nanolubricants, particularly those containing graphene and carbon nanotubes, exhibit marked improvements in reducing friction coefficients and wear rates compared to traditional mineral oil-based lubricants. Additionally, the enhanced thermal stability and load-carrying capacity of these nanolubricants contribute to substantial energy savings and increased operational efficiency. The study underscores the …

The Overlapping Etymology Of Documents, Records, Archives, And Data In Archival Science And Their Re-Conveyance In The Digital Domain Space, Lekoko Kenosi

All Works

The digital transformations currently happening on the net, in cloud computing, and now through generative AI tools- have far-reaching consequences for many disciplines. These transformations have been crosscutting and reconvening boundaries that hitherto defined the information science fields- including their glossaries. This presentation will examine the often overlapping- and sometimes confusing- key archival science terms of documents, records, and data and their etymological metamorphosis within a short period of time due to extraordinary developments in the digital domain space. The presenter concludes with remarks on the ease of archival access, or the lack of it, in a complicated digital world.

Conservation And Management Of Chondrichthyans In The Mediterranean Sea: Gaps, Overlaps, Inconsistencies, And The Way Forward, Jason Lowther, Lydia Koehler, Ioannis Giovos, Jennifer M. Pytka, Monica Barone, Camille Loth, Dimitirios K. Moutoploulos, Simone Niedermuller, Carlotta Mazzoldi

School of Law, Humanities and Social Sciences

Over one third of sharks, rays and chimaeras (chondrichthyans) are threatened with extinction globally. In the Mediterranean Sea, more than half of chondrichthyan species face this risk, although a variety of international, regional, and national rules and regulations apply directly and indirectly targeting management and conservation for these species. In this work, we provide an overview of relevant legislation and policies in the region, which regulate, inter alia, commercial fisheries, while highlighting through cases studies how implementation in practice at national level looks like. Horizontal gaps and inconsistencies that hinder chondrichthyan management in the region are also illustrated. Furthermore, we …

Reported Incidence Of Infections Caused By Pathogens Transmitted Commonly Through Food: Impact Of Increased Use Of Culture-Independent Diagnostic Tests - Foodborne Diseases Active Surveillance Network, 1996-2023, Hazel J. Shah, Rachel H. Jervis, Katie Wymore, Tamara Rissman, Bethany Laclair, Michelle M. Boyle, Kirk Smith, Sarah Lathrop, Suzanne Mcguire, Rosalie Trevejo, Marcy Mcmillian, Stic Harris, Joanna Zablotsky Kufel, Kennedy Houck, Carey E. Lau, Carey J. Devine, Dave Boxrud, Daniel L. Weller

Pathology Research and Scholarship

Reducing foodborne disease incidence is a public health priority. This report summarizes preliminary 2023 Foodborne Diseases Active Surveillance Network (FoodNet) data and highlights efforts to increase the representativeness of FoodNet. During 2023, incidences of domestically acquired campylobacteriosis, Shiga toxin-producing Escherichia coli infection, yersiniosis, vibriosis, and cyclosporiasis increased, whereas those of listeriosis, salmonellosis, and shigellosis remained stable compared with incidences during 2016-2018, the baseline used for tracking progress towards federal disease reduction goals. During 2023, the incidence and percentage of infections diagnosed by culture-independent diagnostic tests (CIDTs) reported to FoodNet continued to increase, and the percentage of cases that yielded an …

Optimizing Associative Memory In Autistic And Non-Autistic Adults: Retrieval Practice, Post-Retrieval Feedback, And Gesture, Brianna E. Cairney

LSU Doctoral Dissertations

Associative memory—or the ability to form a memory representation linking two previously unrelated concepts—is a critical aspect of learning. This work provides insight into strategies that can be used to support associative memory, their underlying mechanisms, and their effectiveness in autistic and non-autistic learners. Chapter 1 demonstrates that iconic gestures can be used as a tool to enhance associative memory by increasing word concreteness and imageability. This effect was eliminated when the iconic gestures were interspersed with ambiguous nonsense gestures, suggesting a boundary on these benefits that depends on listener expectations regarding gesture clarity. However, it remains unknown whether gestures …

Impact Of Isotype On The Mechanism Of Action Of Agonist Anti-Ox40 Antibodies In Cancer: Implications For Therapeutic Combinations, Jane E Willoughby, Lang Dou, Sabyasachi Bhattacharya, Heather Jackson, Laura Seestaller-Wehr, Laura Bover, Kerry L Cox, Tom Murray, Mel John, Hong Shi, Paul Bojczuk, Junping Jing, Heather Niederer, Andrew J Shepherd, Laura Hook, Stephanie Hopley, Tatyana Inzhelevskaya, Chris A Penfold, C Ian Mockridge, Vikki English, Sara J Brett, Roopa Srinivasan, Christopher Hopson, James Smothers, Axel Hoos, Elaine Paul, Stephen L Martin, Peter J Morley, Niranjan Yanamandra, Mark S Cragg

Faculty, Staff and Student Publications

BACKGROUND: OX40 has been widely studied as a target for immunotherapy with agonist antibodies taken forward into clinical trials for cancer where they are yet to show substantial efficacy. Here, we investigated potential mechanisms of action of anti-mouse (m) OX40 and anti-human (h) OX40 antibodies, including a clinically relevant monoclonal antibody (mAb) (GSK3174998) and evaluated how isotype can alter those mechanisms with the aim to develop improved antibodies for use in rational combination treatments for cancer.

METHODS: Anti-mOX40 and anti-hOX40 mAbs were evaluated in a number of in vivo models, including an OT-I adoptive transfer immunization model in hOX40 knock-in …

Hur Controls Glutaminase Rna Metabolism, Douglas Adamoski, Larissa M Dos Reis, Ana Carolina Paschoalini Mafra, Felipe Corrêa-Da-Silva, Pedro Manoel Mendes De Moraes-Vieira, George A Calin

Faculty, Staff and Student Publications

Glutaminase (GLS) is directly related to cell growth and tumor progression, making it a target for cancer treatment. The RNA-binding protein HuR (encoded by the ELAVL1 gene) influences mRNA stability and alternative splicing. Overexpression of ELAVL1 is common in several cancers, including breast cancer. Here we show that HuR regulates GLS mRNA alternative splicing and isoform translation/stability in breast cancer. Elevated ELAVL1 expression correlates with high levels of the glutaminase isoforms C (GAC) and kidney-type (KGA), which are associated with poor patient prognosis. Knocking down ELAVL1 reduces KGA and increases GAC levels, enhances glutamine anaplerosis into the TCA cycle, and …

Genomic Determinants Of Response And Resistance To Inotuzumab Ozogamicin In B-Cell All, Yaqi Zhao, Nicholas J Short, Hagop M Kantarjian, Ti-Cheng Chang, Pankaj S Ghate, Walid Macaron, Beenu Thakral, Aaron H Phillips, Joseph Khoury, Guillermo Garcia-Manero, Wenchao Zhang, Yiping Fan, Hui Yang, Rebecca S Garris, Lewis F Nasr, Richard W Kriwacki, Kathryn G Roberts, Marina Konopleva, Elias J Jabbour, Charles G Mullighan

Faculty, Staff and Student Publications

Inotuzumab ozogamicin (InO) is an antibody-drug conjugate that delivers calicheamicin to CD22-expressing cells. In a retrospective cohort of InO-treated patients with B-cell acute lymphoblastic leukemia, we sought to understand the genomic determinants of the response and resistance to InO. Pre- and post-InO-treated patient samples were analyzed by whole genome, exome, and/or transcriptome sequencing. Acquired CD22 mutations were observed in 11% (3/27) of post-InO-relapsed tumor samples, but not in refractory samples (0/16). There were multiple CD22 mutations per sample and the mechanisms of CD22 escape included epitope loss (protein truncation and destabilization) and epitope alteration. Two CD22 mutant cases were post-InO …

Protein Sumoylation Promotes Camp-Independent Epac1 Activation, Wenli Yang, Fang C Mei, Wei Lin, Mark A White, Li Li, Sheng Pan

Faculty, Staff and Student Publications

Protein SUMOylation is a prevalent stress-response posttranslational modification crucial for maintaining cellular homeostasis. Herein, we report that protein SUMOylation modulates cellular signaling mediated by cAMP, an ancient and universal stress-response second messenger. We identify K561 as a primary SUMOylation site in exchange protein directly activated by cAMP (EPAC1) via site-specific mapping of SUMOylation using mass spectrometry. Sequence and site-directed mutagenesis analyses reveal that a functional SUMO-interacting motif in EPAC1 is required for the binding of SUMO-conjugating enzyme UBC9, formation of EPAC1 nuclear condensate, and EPAC1 cellular SUMOylation. Heat shock-induced SUMO modification of EPAC1 promotes Rap1/2 activation in a cAMP-independent manner. …

Genetically Engineering Glycolysis In T Cells Increases Their Antitumor Function, Raphaëlle Toledano Zur, Orna Atar, Tilda Barliya, Shiran Hoogi, Ifat Abramovich, Noga Ron-Harel

Faculty, Staff and Student Publications

BACKGROUND: T cells play a central role in the antitumor response. However, they often face numerous hurdles in the tumor microenvironment, including the scarcity of available essential metabolites such as glucose and amino acids. Moreover, cancer cells can monopolize these resources to thrive and proliferate by upregulating metabolite transporters and maintaining a high metabolic rate, thereby outcompeting T cells.

METHODS: Herein, we sought to improve T-cell antitumor function in the tumor vicinity by enhancing their glycolytic capacity to better compete with tumor cells. To achieve this, we engineered human T cells to express a key glycolysis enzyme, phosphofructokinase, in conjunction …