Digital Commons Network^™

Sand, Ice, And X-Rays: Developing Xct Methods For Frozen Samples And Refining Siliciclastic Facies Models For Perennially Ice-Covered Lakes, Utilizing Cores From Lake Fryxell, Mcmurdo Dry Valleys, Antarctica, Holly M. Levett

Earth and Planetary Sciences ETDs

Sedimentation in perennially ice-covered lakes (PICLs) is proposed to be bi-modal, with mud deposited by stream inflow and sand deposited on the ice cover by aeolian processes and then melting through by absorption of solar radiation. Here, we consider Lake Fryxell, a PICL in the McMurdo Dry Valleys, and several lake bed cores about 30 cm in length, to better understand PICL facies through time, using micro X-ray CT (XCT). Using XCT images along with sieve and laser granulometry data, we constrained the grain-size of PICL deposits to dominantly medium / fine sand with a coarse component. The presence of …

Critical Geospatial Data Science: Principles For Curating, Analyzing, And Sharing Geospatial Data, Daniel Beene

Geography ETDs

Critical geospatial data science (CGDS) offers principles for engaging with geospatial data, methods, and translation by pulling from critical epistemologies in geography. CGDS interrogates objective “truths” in science by actively engaging in critique of geospatial data and methodologies. Specifically, CGDS contends with the political context and motivations behind geospatial data science (GDS) while using GDS methods to understand how social-spatial arrangements manifest and are reinforced through data. CGDS explicitly aims to inform practices for criticality from within GDS and provides opportunities for multidisciplinary research that incorporates social theories, contextualizes geospatial data, and critically evaluates the effects and ethics of (under)representation …

Functional And Structural Analysis Of The Neimann-Pick Disease Type C Pathway To Include Caveolin-1, Anthony Michael Seat

Chemistry and Chemical Biology ETDs

Human disease is often thought of as an all or nothing prospect, either one has the disease or one does not. This does not bear out in clinical or personal experiences, instead demonstrating that disease occurs within a spectrum ranging from presumed unaffected to demonstrably and detrimentally affected.Neimann-Pick disease is one example of this spectrum look into diseased states, with multiple named versions of a phenotypically similar disease. We focus on Neimann-Picktype C (NPC), which is the result of a disruption in the efflux of cholesterol and sphingolipids from the endocytic pathway. NPC demonstrates this concept of a spectrum of …

Essays Analyzing Economic Consequences Of Caste Dynamics In India, Nikhil Ganvir

Economics ETDs

Scheduled Castes (SC) and Scheduled Tribes (ST) are historically disadvantaged communities that face discrimination on the grounds of their lower social positioning in society. This dissertation comprises 5 Chapters. Chapter 1 provides a brief outline regarding the stratification in India based on Caste and illustrates the importance of studying the economic consequences of caste-based discrimination in India. Chapter 2 analyses the effect of caste-based residential segregation in rural India and its effect on marginalized children's education outcomes. The results show that caste residential segregation dampens the education outcomes for children belonging to SC/ST communities with no discernable effects on students …

A Recreational Sport To Promote Interprofessional Education Among Health Science Center Student-Learners, Isabella Bernino, Cameron Samrai, Dylan Werner, Alyssa West, Vinh Tran

InterProfessional Education Research and Scholarship

This work seeks to disseminate the results of a series of interprofessional education (IPE) events focused around the team sport of spikeball held at the University of New Mexico Health Science Center. Physical therapy student-learners organized and implemented a bimonthly event over the course of two scholastic semesters to bring together other graduate learners from various health profession programs including medicine, nursing, emergency medical technician, dental hygienists, and others. The events offered an opportunity for peer-to-peer education among the various student-learners in an informal environment. The peer-to-peer format of the event is novel and significant, demonstrating a method to promote …

Quality Improvement: Supporting Vulnerable Patients In Medicaid Enrollment, Annslee J. Lowe, Sahana Ummadi, Riana R. Wurzburger

InterProfessional Education Research and Scholarship

Many patients experiencing homelessness also lack health insurance. These patients are often eligible for federal insurance programs, but lack the resources needed to enroll. Well-meaning clinicians and social workers generally do not have the time or resources to address these disparities. The lack of a centralized process for Medicaid enrollment for patients experiencing homelessness perpetuates adverse health outcomes due to multiple factors. 1) Lack of care: avoidance of seeking health care and minimal preventative care; 2) poor quality care: compared to patients with more resources; 3) lack of follow-up: in part due to unreliable contact information; and 4) “non-adherence”: often …

Diagnostic Evaluation Of Dizziness In Obstetric Triage, Annslee J. Lowe, Anna Shields

InterProfessional Education Research and Scholarship

Dizziness is a non-specific term used to describe various sensations of spinning, disequilibrium, imbalance, or near-syncope. The differential diagnosis for this symptom is rather extensive and includes potentially dangerous etiologies, which contributes to the significance of diagnostic evaluation. Dizziness is a frequent concern prompting pregnant patients to seek medical care, and the hemodynamic changes that occur in pregnancy further complicate clinical assessment in obstetric (OB) triage. While often familiar with dizziness as a symptom of hypertensive disorders of pregnancy, many OB triage providers experience uncertainty in working up other causes of dizziness. Root causes for uncertainty and the potential for …

The Intersection Of Covid-19 And Rural Health Infrastructure: Evidence From Rural New Mexicans, Maria Gaboldon-Parish, Kate Cartwright

InterProfessional Education Research and Scholarship

Rural communities experience notable health disparities compared to urban areas. These include an aging population with higher illness rates, worsened by inadequate healthcare infrastructure. Shortages in healthcare facilities, supplies, testing sites, and medical personnel further exacerbate these disparities, especially in remote areas. Addressing these challenges is crucial for equitable healthcare delivery and improving health outcomes statewide. Our goal is to analyze rural New Mexican residents’ perceptions of their community’s infrastructure and its interconnection with health. Key themes include (1) the disparities in community and public resources available, (2) limited access to healthcare facilities due to distance, staff shortages, and limited …

College Of Nursing And Dietetic Intern Ng Tube Placement Training And Nutrition Assessment/Formula Selection Interprofessional Education Activity - A Student Perspective, Kimberly Jaramillo, Josephine Titus, Amanda Dunn, Diana Gonzales-Pacheco

InterProfessional Education Research and Scholarship

Introduction

University of New Mexico College of Nursing (CON) students and College of Education and Health Sciences (COEHS) dietetic interns (DI) participated in an IPE activity to fulfill the Dietetic Internship (DI) competency for (NG) tube placement and CON clinical objectives.

Methods

Fourteen pre-licensure BSN students and seven DI graduate students participated in the IPE activity. CON students presented nursing roles during NG tube placement and answered questions regarding clinical experiences. In small groups, nursing students demonstrated NG tube placement procedures using simulation mannequins, which the dietetic interns then practiced.

The dietetic interns presented the role of registered dietitian nutritionists. …

Script Your Future 2024, Alexander Nihart, Nicholas Olivas, Kaitlyn Zbylut, Amy Bachyrycz, Melissa Martinez

InterProfessional Education Research and Scholarship

Script Your Future (SYF) is an annual campaign run by the National Consumers League (NCL) which promotes health outreach by health professions students. A number of focus areas are established each year, with the foundation being the promotion of medication adherence. The UNM College of Pharmacy student leaders, with assistance from the IPE office, called for students from all programs on the Health Science Center (HSC) campus to come together as a part of SYF.

This is extremely important because, as the NCL states, medication adherence is a cornerstone of effective disease treatment, with non-adherence being the cause of an …

Equitable Care During Incarceration, Lisa M. Taylor, Clarissa Spiro

InterProfessional Education Research and Scholarship

There are over 2 million people in the varied US detention centers including state and federal prisons, local jails, juvenile detention facilities, Indian Country jails, military prisons, immigration detention facilities, and civil commitment centers., with an estimated 9% living with diabetes where the US average is 10% (ADA position statement, 2021). The Metropolitan Detention Center (MDC) is the largest behavioral health provider in Albuquerque, outside of the corrections facilities, but this jail also has acute and chronic care access for inmates, as well as addiction medicine. The population is vulnerable to gaps in care and poor health outcomes due to …

Institution-Wide Strategy For Increasing Diversity In Healthcare Professions, Rhudovic Ramos, Anna Lee, Amy Greene

InterProfessional Education Research and Scholarship

The goal of this study is to describe and evaluate the federally funded health professions program at the University of New Mexico (UNM), the Undergraduate Student Scholars Program (USSP), which aims to support educationally or economically disadvantaged students interested in pursuing healthcare professions and working with medically underserved populations. The USSP is a yearly program that aims to support students with monthly career development workshops. Enrollment into the program requires an application process that includes short essay responses demonstrating their interests in healthcare. A post-program survey was sent to all participants in the 2023–2024 academic year upon completion of the …

Transcriptome-Wide Genetic Variations In The Legume Genus Leucaena For Fingerprinting And Breeding, Yong Han, Alexander Abair, Julian Van Der Zanden, Madhugiri Nageswara-Rao, Saipriyaa Purushotham Vasan, Roopali Bhoite, Marieclaire Castello, Donovan Bailey, Clinton K. Revell Dr, Chengdao Li, Daniel Real

Grain and Other Field Crops Research Articles

Leucaena is a versatile legume shrub/tree used as tropical livestock forage and in timber industries, but it is considered a high environmental weed risk due to its prolific seed production and broad environmental adaptation. Interspecific crossings between Leucaena species have been used to create non-flowering or sterile triploids that can display reduced weediness and other desirable traits for broad use in forest and agricultural settings. However, assessing the success of the hybridisation process before evaluating the sterility of putative hybrids in the target environment is advisable. Here, RNA sequencing was used to develop breeding markers for hybrid parental identification in …

Multiparametric Mri-Based Radiomic Models For Early Prediction Of Response To Neoadjuvant Systemic Therapy In Triple-Negative Breast Cancer, Rania M Mohamed, Bikash Panthi, Beatriz E Adrada, Medine Boge, Rosalind P Candelaria, Mary S Guirguis, Lei Huo, Ken-Pin Hwang, Anil Korkut, Jennifer K Litton, Tanya W Moseley, Sanaz Pashapoor, Miral M Patel, Brandy Reed, Marion E Scoggins, Jong Bum Son, Alastair Thompson, Debu Tripathy, Vicente Valero, Peng Wei, Jason White, Gary J Whitman, Zhan Xu, Wei Yang, Clinton Yam, Jingfei Ma, Gaiane M Rauch

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) is often treated with neoadjuvant systemic therapy (NAST). We investigated if radiomic models based on multiparametric Magnetic Resonance Imaging (MRI) obtained early during NAST predict pathologic complete response (pCR). We included 163 patients with stage I-III TNBC with multiparametric MRI at baseline and after 2 (C2) and 4 cycles of NAST. Seventy-eight patients (48%) had pCR, and 85 (52%) had non-pCR. Thirty-six multivariate models combining radiomic features from dynamic contrast-enhanced MRI and diffusion-weighted imaging had an area under the receiver operating characteristics curve (AUC) > 0.7. The top-performing model combined 35 radiomic features of relative difference between …

Patient-Reported Quality Of Life At Diagnosis In Adolescent And Young Adults With Cancer, Goldy C George, Clark Andersen, Xiaohui Tang, Elizabeth Rodriguez, Midhat Jafry, Sairah Ahmed, J Andrew Livingston, Michael E Roth, Michelle A T Hildebrandt

Faculty, Staff and Student Publications

Background: The overall landscape of health-related quality of life (HRQoL) has not been thoroughly investigated in adolescents and young adults (AYAs) with cancer. Data are also lacking on how well HRQoL at the time of cancer diagnosis can prognosticate long-term survival in AYA survivors.

Patients and methods: We included 3,497 survivors of AYA cancer (age 15-39 years at diagnosis) who completed the Short-Form 12 Health Survey (SF-12) HRQoL questionnaire at diagnosis. Physical component summary (PCS) and mental component summary (MCS) scores were generated, with scores < 50 representing poor HRQoL. Differences in HRQoL by patient characteristics and tumor type were investigated using violin plots and t tests/analysis of variance. The effect of HRQoL on overall survival was assessed using Kaplan-Meier plots and Cox proportional hazards models.

Results: Overall mean PCS and MCS scores in this racially/ethnically diverse cohort (64% White, 19% …

Real-World Evidence Study On The Early Use Of Cemiplimab In The Uk: React-Cemi (Real World Evidence Of Advanced Cscc Treatment With Cemiplimab), Juan Carlos Lopez-Baez

Faculty, Staff and Student Publications

BACKGROUND: Cemiplimab was licensed in the United Kingdom (UK) in 2019 for the treatment of patients with locally advanced and metastatic CSCC not suitable for curative surgery or radiotherapy (advanced CSCC [aCSCC]). No UK multi-center studies have investigated the real-world experience of cemiplimab post marketing authorization in aCSCC.

METHODS: This non-interventional retrospective study (10 UK centers) involved data collection from medical records of patients with aCSCC who initiated cemiplimab treatment between 2 July 2019 and 30 November 2020. The study period was a minimum of 12 and a maximum of 36 months post cemiplimab initiation. The primary objective was to …

Dansyl Fluorophore Functionalized Hierarchically Structured Mesoporous Silica Nanoparticles As Novel Latent Fingerprint Development Agents, Lais F A M Oliveira, Lais V A T Da Silva, Artur F Sonsin, Meclycia S Alves, Cristiane V Costa, Nicholas Ross, Thomas Zinn, Ticiano G Do Nascimento, Eduardo J S Fonseca, Alexandro M L De Assis, A Robert Hillman, Adriana S Ribeiro

Faculty, Staff and Student Publications

A nanostructured hybrid material based on mesoporous silica nanoparticles (MCM-41) functionalized with chitosan and a fluorescent dye (dansylglycine), designated MCM-41@Ch@DnsGly, was synthesized and characterized with a view to its application for the visualization of latent fingerprints. These nanoparticles were applied as latent fingerprint developers for marks on surfaces of diverse chemical composition, topography, optical characteristics, and spatially variant nature, typical of forensically challenging evidence. For quality assessment of the enhanced fingermarks, the developed images were analyzed holistically using the UK Home Office scale, forensic protocols and, in terms of their constituent features (minutiae), using forensic software. Across a substantive collection …

Learning To Express Reward Prediction Error-Like Dopaminergic Activity Requires Plastic Representations Of Time, Ian Cone, Claudia Clopath, Harel Z Shouval

Faculty, Staff and Student Publications

The dominant theoretical framework to account for reinforcement learning in the brain is temporal difference learning (TD) learning, whereby certain units signal reward prediction errors (RPE). The TD algorithm has been traditionally mapped onto the dopaminergic system, as firing properties of dopamine neurons can resemble RPEs. However, certain predictions of TD learning are inconsistent with experimental results, and previous implementations of the algorithm have made unscalable assumptions regarding stimulus-specific fixed temporal bases. We propose an alternate framework to describe dopamine signaling in the brain, FLEX (Flexibly Learned Errors in Expected Reward). In FLEX, dopamine release is similar, but not identical …

A Hybrid Epithelial/Mesenchymal State In Head And Neck Cancer: A Biomarker For Survival With Differential Prognosis By Self-Reported Race, Angela L Mazul, Thomas F Barrett, Graham Colditz, Anuraag S Parikh, Salma Ramadan, Jose P Zevallos, Jason T Rich, R Alex Harbison, Ryan S Jackson, Patrik Pipkorn, Paul Zolkind, Itay Tirosh, Sidharth V Puram

2020-Current year OA Pubs

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is the 6

METHODS: Given the overlap in gene expression between hybrid E/M malignant cells and cancer-associated fibroblasts, we utilized deconvolution of bulk RNA sequencing data from oral cavity and laryngeal squamous cell carcinoma tumors from The Cancer Genome Atlas. We utilized our previously collected single-cell profiles to generate inferred malignant profiles and then scored these for hybrid E/M. We then conducted a survival analysis on overall and disease-free survival among self-reported Black and White Americans.

FINDINGS: The hybrid E/M state was differentially associated with head and neck cancer survival by self-reported …

Thermodynamic Coupling Of The Tandem Rrm Domains Of Hnrnp A1 Underlie Its Pleiotropic Rna Binding Functions, Jeffrey D Levengood, Davit Potoyan, Srinivasa Penumutchu, Abhishek Kumar, Qianzi Zhou, Yiqing Wang, Alexandar L Hansen, Sebla Kutluay, Julien Roche, Blanton S Tolbert

2020-Current year OA Pubs

The functional properties of RNA binding proteins (RBPs) require allosteric regulation through interdomain communication. Despite the importance of allostery to biological regulation, only a few studies have been conducted to describe the biophysical nature by which interdomain communication manifests in RBPs. Here, we show for hnRNP A1 that interdomain communication is vital for the unique stability of its amino-terminal domain, which consists of two RNA recognition motifs (RRMs). These RRMs exhibit drastically different stability under pressure. RRM2 unfolds as an individual domain but remains stable when appended to RRM1. Variants that disrupt interdomain communication between the tandem RRMs show a …

Monoallelic De Novo Ajap1 Loss-Of-Function Variants Disrupt Trans-Synaptic Control Of Neurotransmitter Release, Vita Sereikaite, Li-Yuan Chen, Diego Fernandez-Fernandez, Pascal D Rem, Daniel Ulrich, Jochen Schwenk, Ziyang Chen, Elodie Le Monnier, Thorsten Fritzius, Sabrina M Innocenti, Valérie Besseyrias, Luca Trovò, Michal Stawarski, Emanuela Argilli, Elliott H Sherr, Bregje Van Bon, Erik-Jan Kamsteeg, Maria Iascone, Alba Pilotta, Maria R Cutrì, Mahshid S Azamian, Andrés Hernández-García, Seema R Lalani, Jill A Rosenfeld, Xiaonan Zhao, Tiphanie P Vogel, Herda Ona, Daryl A Scott, Peter Scheiffele, Kristian Strømgaard, Mehdi Tafti, Martin Gassmann, Bernd Fakler, Ryuichi Shigemoto, Bernhard Bettler

Faculty, Staff and Students Publications

Adherens junction–associated protein 1 (AJAP1) has been implicated in brain diseases; however, a pathogenic mechanism has not been identified. AJAP1 is widely expressed in neurons and binds to γ-aminobutyric acid type B receptors (GBRs), which inhibit neurotransmitter release at most synapses in the brain. Here, we show that AJAP1 is selectively expressed in dendrites and trans-synaptically recruits GBRs to presynaptic sites of neurons expressing AJAP1. We have identified several monoallelic AJAP1 variants in individuals with epilepsy and/or neurodevelopmental disorders. Specifically, we show that the variant p.(W183C) lacks binding to GBRs, resulting in the inability to recruit them. Ultrastructural analysis revealed …

To Evaluate Efficiency Of Various Coronary Artery Disease Risk Scores With Traditional Risk Factors In Patients Undergoing Coronary Angiography, Sharma Kamal, Panwar Jasraj, Patel Krutika, Parmar Devratsinh, Kalyani Maulik, Dhorajiya Dixit

Journal of the Saudi Heart Association

Objective:

To analyze and compare various cardiovascular disease risk scores in Western Indian patients undergoing Coronary angiogram (CAG).

Methods:

In this prospective cross-sectional study,1213 patients who underwent conventional coronary angiography; clinical risk profile and biochemical investigations were evaluated prior to undergoing CAG. Apart from the demographic information, 10-year absolute risk of having a major cardiovascular event (cardiovascular death, myocardial infarction or stroke) was calculated for each patient using various available Traditional Risk Scores (TRS). The population was divided in low, intermediate and high-risk categories for each of these scores.

Results:

Traditional cardiovascular risk factors like hypertension (41.8%) and diabetes mellitus-II …

Ultrasound-Guided Vs. Standard Coronary Access In Coronary Angiography: A Systematic Review And Meta-Analysis, Ibrahim Omer, Mohammed Bukhari, Mohammad Alsharif, Abdulrahman Alsamadani, Dinah Alahmadi, Ali Saleh Alsudais, Abdullah Abdulkareem, Hashem Alhashmi Alamir

Journal of the Saudi Heart Association

Objectives: Coronary angiography is a procedure performed during cardiac catheterization to define the coronary anatomy and determine the extent of coronary artery disease (CAD). The use of a cheap, relatively available tool like an ultrasound machine to assist in vascular access might reduce the risks associated with blind access. This study aimed to explore the efficacy and associated complications of ultrasound-guided coronary artery catheterization. Methods: This systematic review of randomized controlled trials (RCTs) was conducted according to the Preferred Reporting Item for Systematic Reviews and Meta-Analysis (PRISMA) and was registered in PROSPERO (CRD42022365518). A systematic search was performed for all …

Giardiasis: A Review Study In Iraq, Sarah Kamal Naser

Al-Ameed Journal for Medical Research and Health Sciences

Background: Giardia lamblia is the parasite that causes giardiasis, small intestine infection can result in severe issues and persistent symptoms, especially in children, giardiasis is a common diarrheal disease that can affect anyone everywhere in the world. It may not show any signs at all or it may result in symptoms like intermittent flatulence or persistent malabsorption, Giardia antigen  test,  molecular test for the presence of parasite DNA in feces, and identification of the organism in fresh stool or duodenal contents are all methods of diagnosis.

Aims: Finding the prevalence of giardiasis among cities is the purpose of this review …

Emotional Capital And Compassionate Educational Space: Reflection On One Undergraduate Course, Katerina Bodovski

Journal of Contemplative and Holistic Education

In this essay, I reflect upon my experience of creating and teaching a new undergraduate course, Students, Parents, Schools. I look at the course content and process through the lens of emotional capital. While being one of the themes in the course, emotional capital is also developed for the students within the class itself. I identified four aspects of the course that can be linked to building emotional capital: bringing focus to oneself; encouraging students to capitalize on their own experiences; building meaningful connections; and creating a non-punitive environment. I discuss each of the aspects, illustrating them where appropriate …

An Epidemiological Study Of Tinea Corporis In Al-Najaf City, Ahmed Rashad Rasool, Amel Mustafa Kamil, Dhakam Mohammed Abbas

Maaen Journal for Medical Sciences

Background: Dermatophytes are humans' and animals' primary causative agents in charge of cutaneous fungal infections. Understanding the epidemic behavior of dermatophytosis, such as Tinea corporis, which specifically affects the trunk, neck, and extremities, might aid in its prevention. Aim of the study: The study aims to determine the proportion of Tinea corporis and dermatophytosis, the clinical type distribution of dermatophytosis, and participant demographics for Tinea corporis. Method: a cross-sectional study focuses on individuals diagnosed with Tinea corporis in the three general hospitals in Al-Najaf City the study takes place from April 1st to July 31st. all cases with tinea corporis …

The Contributors, Contributors

Budhi: A Journal of Ideas and Culture

No abstract provided.

Babaylan Sing Back: Philippine Shamans And Voice, Gender, And Place, By Grace Nono, Agustin Martin G. Rodriguez

Budhi: A Journal of Ideas and Culture

No abstract provided.

The Baby On The Fire Escape: Creativity, Motherhood, And The Mind-Baby Problem, By Julie Phillips, Pamela Joy Mariano-Capistrano

Budhi: A Journal of Ideas and Culture

No abstract provided.

Radical Democracy In The Time Of Duterte, By Christopher Ryan Maboloc, Symel Noelin S. De Guzman-Daulat

Budhi: A Journal of Ideas and Culture

No abstract provided.