Digital Commons Network^™

Ragopathies And The Rising Influence Of Raggtpases On Human Diseases, Irene Sambri, Marco Ferniani, Andrea Ballabio

Duncan NRI Faculty and Staff Publications

RagGTPases (Rags) play an essential role in the regulation of cell metabolism by controlling the activities of both mechanistic target of rapamycin complex 1 (mTORC1) and Transcription factor EB (TFEB). Several diseases, herein named ragopathies, are associated to Rags dysfunction. These diseases may be caused by mutations either in genes encoding the Rags, or in their upstream regulators. The resulting phenotypes may encompass a variety of clinical features such as cataract, kidney tubulopathy, dilated cardiomyopathy and several types of cancer. In this review, we focus on the key clinical, molecular and physio-pathological features of ragopathies, aiming to shed light on …

Hemodynamics Regulate Spatiotemporal Artery Muscularization In The Developing Circle Of Willis, Siyuan Cheng, Ivan Fan Xia, Renate Wanner, Javier Abello, Amber N Stratman, Stefania Nicoli

2020-Current year OA Pubs

Vascular smooth muscle cells (VSMCs) envelop vertebrate brain arteries and play a crucial role in regulating cerebral blood flow and neurovascular coupling. The dedifferentiation of VSMCs is implicated in cerebrovascular disease and neurodegeneration. Despite its importance, the process of VSMC differentiation on brain arteries during development remains inadequately characterized. Understanding this process could aid in reprogramming and regenerating dedifferentiated VSMCs in cerebrovascular diseases. In this study, we investigated VSMC differentiation on zebrafish circle of Willis (CoW), comprising major arteries that supply blood to the vertebrate brain. We observed that arterial specification of CoW endothelial cells (ECs) occurs after their migration …

Development And Operationalizing Of The Learning Experience Design Process To Create Integrated Stem Interventions, Vanessa Begat

LSU Doctoral Dissertations

Globally, the demand for people prepared to enter Science, Technology, Engineering and Math (STEM) careers is increasing. To help fill this demand, many formal and informal STEM educational interventions have been implemented in the K-12 domain. However, due to the lack of a clearly defined framework for documenting the nature and scope of the intervention (National Research Council, 2014), the interventions vary greatly in their success, sustainability, and replicability. This research is grounded in Educational Design Research and uses the principle of Learning Experience Design (LXD) to develop a framework for thoughtfully designing and documenting a STEM intervention. This framework …

Tsg-6+ Cancer-Associated Fibroblasts Modulate Myeloid Cell Responses And Impair Anti-Tumor Response To Immune Checkpoint Therapy In Pancreatic Cancer, Swetha Anandhan, Shelley Herbrich, Sangeeta Goswami, Baoxiang Guan, Yulong Chen, Sonali Jindal, Samuel W Andrewes, Liangwen Xiong, Ashwat Nagarajan, Sreyashi Basu, Derek Ng Tang, Jielin Liu, Jimin Min, Anirban Maitra, Padmanee Sharma

Faculty, Staff and Student Publications

Resistance to immune checkpoint therapy (ICT) presents a growing clinical challenge. The tumor microenvironment (TME) and its components, namely tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs), play a pivotal role in ICT resistance; however, the underlying mechanisms remain under investigation. In this study, we identify expression of TNF-Stimulated Factor 6 (TSG-6) in ICT-resistant pancreatic tumors, compared to ICT-sensitive melanoma tumors, both in mouse and human. TSG-6 is expressed by CAFs within the TME, where suppressive macrophages expressing Arg1, Mafb, and Mrc1, along with TSG-6 ligand Cd44, predominate. Furthermore, TSG-6 expressing CAFs co-localize with the CD44 expressing macrophages in the TME. …

Radiation Therapy With Or Without Cisplatin For Local Recurrences Of Endometrial Cancer: Results From An Nrg Oncology/Gog Prospective Randomized Multicenter Clinical Trial, Ann H Klopp, Danielle Enserro, Matthew Powell, Marcus Randall, Julian C Schink, Laura Holman, Christina L Kushnir, Floor Backes, Susan L Zweizig, Steven Waggoner, Kristin A Bradley, Lana Desouza Lawrence, Parviz Hanjani, Christopher J Darus, William Small, Higinia R Cardenes, Jonathan M Feddock, David S Miller

Faculty, Staff and Student Publications

Purpose: Pelvic recurrence is a frequent pattern of relapse for women with endometrial cancer. A randomized trial compared progression-free survival (PFS) after treatment with radiation therapy alone as compared with concurrent chemotherapy.

Materials and methods: Between February 2008 and August 2020, 165 patients were randomly assigned 1:1 to receive either radiation treatment alone or a combination of chemotherapy and radiation treatment. The primary objective of this study was to determine whether chemoradiation therapy was more effective than radiation therapy alone at improving PFS.

Results: The majority of patients had low-grade (1 or 2) endometrioid histology (82%) and recurrences confined to …

The Multifaceted Role Of Neutrophils In Nsclc In The Era Of Immune Checkpoint Inhibitors, Shucheng Miao, Bertha Leticia Rodriguez, Don L Gibbons

Faculty, Staff and Student Publications

Lung cancer is the most common cause of cancer-related death in both males and females in the U.S. and non-small-cell lung cancer (NSCLC) accounts for 85%. Although the use of first- or second-line immune checkpoint inhibitors (ICIs) exhibits remarkable clinical benefits, resistance to ICIs develops over time and dampens the efficacy of ICIs in patients. Tumor-associated neutrophils (TANs) have an important role in modulating the tumor microenvironment (TME) and tumor immune response. The major challenge in the field is to characterize the TANs in NSCLC TME and understand the link between TAN-related immunosuppression with ICI treatment response. In this review, …

Student Stress In Animal Science, Jayden Lynn Lawrence

Theses and Dissertations

Anecdotally, college students have high levels of stress when compared to the rest of the population. There have been many studies that support this idea in programs outside of animal science, but with the shift in animal science from students that have prior livestock experience to those that do not, it is important to acknowledge how this shift impacts the student population. By evaluating courses in animal science, and how they impact student stress it is possible to determine if the present-day curriculum causes any additional stress on students that have less prior experience. In the United States, a majority …

A Medievalist Myth-Making Crisis: Tolkien's Tychonic Cosmology, Kristine Larsen

Journal of Tolkien Research

During and after writing The Lord of the Rings, J.R.R. Tolkien became embroiled in a self-motivated crisis in world-building, endeavoring to ‘modernize’ his mythological cosmology to more accurately reflect the Earth as it exists as a planet orbiting the Sun in space. While Tolkien was ultimately never able to complete a ‘Copernican Revolution’ in his Secondary World, his efforts continued over twenty years through numerous drafts posthumously published in Morgoth’s Ring and The Nature of Middle-earth. This paper applies a particular vignette from our real-world cosmological crises – revisions of Tycho Brahe’s hybrid geo-heliocentric model by Jesuit astronomers …

Administrative Appeal Decision - Mohammad, Malik (2024-03-25)

Parole Administrative Appeal Decisions

No abstract provided.

On Emily Dickinson, Katelyn Confer

2024 Symposium

The following paper will explore the relationship between Emily Dickinson’s poetry, the circumstances of her life, and the historical context in which she lived to glean an understanding of how her mental health influenced her work. Selected poems by Dickinson will be reviewed and analyzed, along with a brief overview of nineteenth century attitudes towards female mental health with a particular emphasis on the medical diagnosis of female hysteria.

Anti-Transgender Care Bans: The Weaponization Of Disinformation And The Political Ploy To Erase Transgender Youth, Gretchen Delight Larmer

2024 Symposium

Since 2021, the United States has seen the introduction of over 1,000 bills targeting transgender rights and 2024 alone, has seen 133 bills introduced that aim to deny healthcare for transgender individuals. Such bills often prevent access to necessary healthcare, particularly gender-affirming care (GAC) for transgender youth. GAC for transgender youth can include care for mental wellness and puberty blockers which temporarily pause the puberty process. Legislators aim to deny transgender youth access to GAC by criminalizing any support given to youth accessing GAC as well as the medical or psychiatric provision of such care. GAC has been negatively and …

Atmospheres Of Ableism: A Phenomenological Exploration Of Everyday Encounters, Kelly Parke

2024 Symposium

Campbell and Nario-Redmond explain that ableism entails explicit and implicit biases that manifest at every level of social life. At the same time, Taussig describes ableism as "the atmosphere we breathe." Disability Studies scholarship has done much to identify how ableism operates in the everyday lives of disabled and non-disabled people alike; however, little work has been done to articulate it in terms of the atmospheric quality that Taussig discusses.

Building on Taussig's assessment of ableism in conjunction with Casey's similar articulation of the atmosphere of emotion, this paper addresses the findings of an online qualitative survey distributed to adults …

Please Don’T Break: Best Practices For Digitizing And Archiving Glass Plate Photographs, Ariel Hammond, Noelle Zocco, Alejandra Tomeo, Diego Jimenez

Journal of Western Archives

Glass plate photographs, taken primarily between 1860-1930, were meant to document and preserve imagery, however, these photographs developed directly on glass are increasingly prone to destruction. With recent advances in imaging techniques, metadata, and collections care, the preservation of glass photography has evolved. This paper is a snapshot of the current best practices for preserving, digitizing, and storing glass plate and lantern slide photographs. It also features a case study from the San Diego Natural History Museum Library & Archives, which digitized a collection of 2,000+ glass photographs depicting the earliest images of flora and fauna in San Diego County, …

Vol. 6 No. 1, Glen Goodknight

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Data Requirements For Whole-Farm Economic Analysis Of Grazing Alternatives, R O. Burton Jr

IGC Proceedings (1977-2023)

The purpose of this paper is to contribute to better communications among the agronomists, animal scientists, and agricultural economists on interdisciplinary teams, that wish to provide useful information to forage producers. This is accomplished by discussing major issues and data requirements for whole-farm economic analysis.

Native Grasslands Of Yugoslavia As A Potential For "Biologically High Quality Food" Production - To Be Preserved And Used For The Benefit Of All, Djordjevic-Milosevic Suzana, Negovanovic Dragan, Zakonovic Miodrag

IGC Proceedings (1977-2023)

Natural grasslands are the base of the livestock production in the hilly-mountainous regions of Yugoslavia. Poor economic power of the owners of these areas brought about a complete dying out of agricultural production in these regions in the last few years. In the same time, the lack of financial resources made it impossible for the farmers to use the fertilisers, protective and other chemical agents which result in a high degree of environmental preservation. Due to current economic policy at this time the population has moved out and there is no industrialisation. The revival of agriculture on the hilly-mountainous regions …

Some Economics Problems Of Range Resource Analysis In Free And Open Access Environment, E Tedonkeng Pamo

IGC Proceedings (1977-2023)

Economic analysis has been the traditional means by which the costs and benefits of rangeland conservation and sustained development have been identified. Conventional analysis has proved inadequate for dealing with the following realities : (1) open access in circumstances of poorly defined common-resource ownership tends to encourage over exploitation; (2) many costs of rangeland degradation involve externalities that will occur in the future; (3) the values of preservation and sustained management are substantial and can be translated into financial assistance; and (4) benefits from rangeland are not often appreciated because of lack of knowledge from rangeland. Recent approaches to economic …

Studies On The Distribution And Formation Of The Meadows In China, Feng Guojun, Zhang Xiujun, Zhu Libuo, Wei Shaocheng, Zhang Yongliang

IGC Proceedings (1977-2023)

The lowland meadows are distributed on the Northeast Plains in the temperate zone in China, and its area became less and less with an increase of longitude. There are some regularities for the distribution of montane meadows, sub-montane meadows and cold-alpinal meadows. And the distribution and formation for meadows are independent upon the zonal climate and their environmental soil moisture.

Sward Structure Under Continuous And Rotation Grazing, V Pavlu, J Velich

IGC Proceedings (1977-2023)

Sward structure under continuous (CG) and rotational (RG) grazing system was studied at an experimental pasture in the Jizerské hory mountains. Herbage mass and vertical distribution was assessed by cutting ten quadrats (0.1 x 0.5 m) and separated into grass, white clover, dandelion, other forbs and dead material. The proportions of grasses was higher at RG (on average 51% of the pasture mass) than at CG (41%). In the years with normal amount and distribution of precipitation the proportion of white clover was higher at CG (17%) than at RG (9%). The lack of summer precipitation damaged more significantly the …

Beef Cattle Production On Renovated Grass Pastures In Savannas Of Brazil, V.P B. Euclides, M.C M. Macedo, M P. Oliveira

IGC Proceedings (1977-2023)

A 3-year grazing trial was conducted, to study animal production on degraded grass pastures, renovated by two levels of fertilization. All paddocks were divided into halves: one received 1.5 t/ha of dolomitic limestone, 400 kg/ha of a fertilizer formula 0-16-18 and 50 kg/ha of microelements (FL1); and the other 3.0 t/ha , 800 kg/ha and 50 kg/ ha of the same fertilizers (FL2). Productivity on FL2 pastures was greater than that on FL1 pastures, averaging 565 and 395 kg of liveweight gain (LWG)/ha/year, respectively. For all grasses the productivity in both fertilizer treatments decreased linearly from the first to the …

Pasture Attributes And Live-Weight Gain Of Lambs Grazing With Different Supplementation Levels, P A. Martinez-Hernandez, M Meza-Nieto, J Perez-Perez, R Barcena, J G. Herrera

IGC Proceedings (1977-2023)

The purpose of this study was to determine pasture attributes, liveweight gain and stocking rate from a mixed pasture grazed by lambs recieving different supplementation levels. There were four treatments: in two, lambs grazed at 4 or 8% herbage allowance, no supplement; in the other two, lambs grazed at 4% herbage allowance plus a concentrate to cover 25 and 30 or 50 and 60% of estimated daily needs of metabolizable energy and crude protein. Pasture was of perennial and annual ryegrass, orchard grass and red clover. Pre and postgrazing forage mass, crude protein and dead material were not different (P …

Characteristics Of Grass Species In Pasture For High Producing Cows In Northern Japan, K Sudo, K Ochiai, T Ikeda

IGC Proceedings (1977-2023)

The prupose of this research was to investigate characteristics of grass species under different conditions appropriate to the intensive grazing system for high producing cows (8000 kg for a 305-day lactation) in northern Japan. Meadow fescue (Festuca elatior L.), timothy (Phleum pratense L.) and perennial ryegrass (Lolium perene L.) white clover (Trifolium repens L.) pastures were established and divided into two plots by difference of regulated plant height (meadow fescue and timothy) or of stocking intensity (perennial ryegrass). Each plot was 60m2 and was grazed when plant height reached 20cm or 30cm. Meadow fescue and perennial …

The Judicial Humorist (Ed. William L. Prosser, 1952), George John Miller

Florida Law Review

No abstract provided.

Advance To Barbarism (F. J. P. Veale, 1953), Justin C. Montgomery

Florida Law Review

No abstract provided.

Supreme Court And Supreme Court Law: A Symposium (Ed. Edmond Cahn, 1954), John R. Starrs

Florida Law Review

No abstract provided.

Role Of China’S Belt And The Road Initiative In Global Development Finance, Srinivasa Madhur

The Journal of International Relations, Peace Studies, and Development

China’s Belt and the Road Initiative (BRI), introduced in 2013 by China’s President Xi, has been a major milestone in global development finance. Resonating with the historical ‘Silk Road”, BRI attempts to connect many countries and continents around the world. Matching its humongous size of nearly $1 trillion, it covers about 165 countries around the world. Even as the BRI benefitted some of the recipient countries, it has built a mountain of debt among many developing countries. This paper suggests an efficient, equitable, and representative method of resolving the BRI debt-distress through the formation of a BRI Club, which should …

Impacts Of The Russo-Ukrainian Conflict On Food Security In Sub-Sahara Africa, Dare Isaac Akindoyin

The Journal of International Relations, Peace Studies, and Development

As an eccentric surprise to global food supply security, the invasion of Ukraine by Russia in February 2022 has the potential to undermine national and international initiatives to combat poverty and hunger. Africa, which is widely believed to be at the receiving end of globalization and development is at the mercy of food insecurity as a result of Ukraine unproved attacked by Russia. This research paper evaluates the impact of Russia's invasion of Ukraine on food security and food supply particularly in Sub-Sahara Africa. The time of the incursion and the two states involved in the conflict are two notable …

Natural Dialectics: Māori & Sioux Ecosophy Encounters The Rule Of Law, Robert T.F. Downes

The Journal of International Relations, Peace Studies, and Development

In the age of intensifying anthropogenic climate change, an ecosophical shift is required in the epistemological and ontological comprehension of the interrelations between the human and non-human worlds. This shift is essential for refining existing social scientific approaches to investigating and adjudicating questions of environmental governance, environmental justice, environmental sovereignty, in addition to advancing democratic counters to the effects of ecological degradation and environmental catastrophe that move beyond rigid political-economic constraints. This essay constitutes a novel engagement with discourses of radical democracy and radical ecology that applies the philosophical method of dialectical naturalism to an ecosophical interpretation of the human-nature …

9th Edition Introduction, Patrick Clairzier

The Journal of International Relations, Peace Studies, and Development

Over the last 300 years, the academic journal has grown to become a fundamental part of the process through which public and private institutions share their intellectual capital, communicate developments in their respective fields, and confer the status of the organization to their peers and the interested public at large. Although we currently exist in a social media world that has allowed for greater and broader connectivity, this interconnectedness and almost instantaneous access to information across these ubiquitous media platforms lack the scholarly scrutiny certain issues demand. Thus, this current issue of The Journal of International Relations, Peace Studies & …

Will I Even Teach Writing Anymore? An Examination Of First-Year Writing Faculty’S Responsibility To Teach About Or With Chatgpt, Danielle Derise

International Journal on Responsibility

In late November of 2022, faculty continuing to navigate the considerable teaching and research challenges posed by the ongoing COVID-19 pandemic were confronted with another existential problem: the juggernaut known as ChatGPT. This article will examine the academy’s response to this sudden intrusion of Large Language Models (LLMs) into classrooms, workplaces, and daily life, with a focus on interrogating the responsibility of and to instructors of first-year composition. I argue that the breathless calls to reinvent courses, assignments, and syllabus policies to “accommodate” LLMs play into a normative system and may pose additional barriers to success for students, including those …