Digital Commons Network^™

Iron Oxide Nanozymes Enhanced By Ascorbic Acid For Macrophage-Based Cancer Therapy, Zhongchao Yi, Xiaoyue Yang, Ying Liang, Sheng Tong

Markey Cancer Center Faculty Publications

In recent years, using pharmacological ascorbic acid has emerged as a promising therapeutic approach in cancer treatment, owing to its capacity to induce extracellular hydrogen peroxide (H2O 2) production in solid tumors. The H2 O 2 is then converted into cytotoxic hydroxyl free radicals (HO•) by redox-active Fe2+ inside cells. However, the high dosage of ascorbic acid required for efficacy is hampered by adverse effects such as kidney stone formation. In a recent study, we demonstrated the efficient catalytic conver- sion of H2 O2 to HO• by wüstite (Fe 1−xO) nanoparticles (WNPs) through a heterogenous Fenton reaction. Here, we explore …

Framework And Methodology For Risk-Based Bridge And Tunnel Asset Management: Objective Risk Assessment And Network Level Evaluation, David Y. Yang, Arash Khosravifar, Diane Moug, Avinash Unnikrishnan

Civil and Environmental Engineering Faculty Publications and Presentations

This report presents the results of the project on establishing a general framework and methodology for risk-based bridge and tunnel asset management. The research was carried out at Portland State University in collaboration with engineers and officials at Oregon Department of Transportation (ODOT) and Federal Highway Administration (FHWA). The primary goal of the research is to achieve risk-based transportation asset management based on (a) objective and consistent risk assessment and (b) effective prioritization and optimization of intervention strategies. Volume I of this report presents methods and findings in the base phase (Phase I) of the project, which is focused on …

Using Duckweed As A Green Manure, Nicholas Gosling

UNH Today Archive

No abstract provided.

Researchers Propose Equitable Solution For Allocating Welfare Funds, Aaron Sanborn

UNH Today Archive

No abstract provided.

Physical Activity, Sleep, And Depressive Symptoms Among Cognitively Impaired Older Adults Without Dementia, Debbie Chung

ETD Collection

Depressive symptoms are commonly experienced by older adults experiencing cognitive decline or dementia symptoms. Research is sparse in understanding modifiable drivers of depression among older adults with or without dementia. The current study examines the interplay between insomnia, physical activity, and depressive symptoms among cognitively impaired individuals without dementia. We performed a hierarchical regression analysis to investigate these relationships using the Health and Retirement Study (n=1208). Depressive symptoms and insomnia are based on the self-report, and a negative binomial model to evaluate these relationships with incidence rate ratios (IRRs) and 95% confidence intervals examined this interaction. Holding everything else constant, …

Variations Of Inflammatory Markers Levels (Esr And Crp) In The Perioperative Period Of Total Knee Arthroplasty, Khalil Ibrahim Sadiq, Mohamedbakir Abbas Abdulzahra, Rafid Mousa Jaffar

Iraqi National Journal of Medicine

Background: The preferred method of treatment for severe osteoarthritis of the knee is total knee arthroplasty (TKA). TKA has been linked to a significant increase in inflammatory markers such as erythrocyte sedimentation rate (ESR)—a test that measures how quickly red blood cells settle to the bottom of a test tube—and C-reactive protein (CRP)—a protein made by the liver that increases when there’s inflammation in the body. Aim: Assessment of the typical time trend and physiological kinetics of CRP and ESR during the early postoperative period over 4 weeks Methods: The study was conducted in the Basrah arthroplasty center, from June …

The Moderating Effect Of Leadership Style On The Relationship Between Perceptions Of Organizational Justice And The Performance Appraisal Satisfaction Of Sport Employees, Jeffrey S. White

LSU Doctoral Dissertations

This dissertation is an examination of how leadership style influences the relationship between sport employee perceptions of organizational justice and their satisfaction with performance appraisals. Sport employees are integral to the sport ecosystem, contributing to the physical, mental, and professional development of athletes, the operational success.

Focusing on these crucial constructs, the purpose of this study is to examine the moderating effect of leadership style on the relationship between organizational justice and performance appraisal satisfaction among sport employees. This quantitative empirical research utilizes PLS-SEM and multiple regression analysis with an aim to confirm the relationship between organizational justice and PAS …

Leveraging The Genomic Tools To Explore The Molecular Basis Of Salinity Tolerance In Rice And Soybean, Rajat Pruthi

LSU Doctoral Dissertations

Salinity stress significantly challenges agricultural productivity, particularly affecting major crops like rice and soybean. This research investigates the genetic basis of salt tolerance in both crops through high-resolution genetic mapping, genome-wide association studies (GWAS), and RNA-Seq analysis. In rice, we examined quantitative trait loci (QTLs) associated with salt tolerance at the seedling and flowering stages using a population of advanced backcrossed introgression lines (ILs). A genetic map, constructed with 14,230 polymorphic SNP markers, identified distinct QTLs and candidate genes for salt tolerance at both stages, suggesting differential genetic controls. Notable genes such as OsHAK13 and OsCYP21-4 were upregulated under salt …

Elementary Science Teachers' Experiences: A Case Study On The Use Of Science+Cyber Curriculum, Laurie Salvail

LSU Doctoral Dissertations

The field of science education in the United States has undergone a major reform since 2015. A little more than twelve years ago, work began on constructing a framework for elementary, middle, and high school science education. This framework emphasized the shift from science being merely a memorization of facts to experiences that include science and engineering practices applied through crosscutting concepts and focused on core ideas in the field of science. With new standards teachers also have to overcome a) not having adequate time available to devote to science instruction b) lack of updated instructional materials aligned to the …

The Role Of Sexual Network Core Groups In Disease Epidemics, Jason Janeaux

LSU Doctoral Dissertations

Sexually transmitted infections (STIs) remain an economic and social burden, non-discriminately affecting sexually active individuals worldwide. The unique transmission of STIs is dependent upon host and pathogen life histories, as well as the underlying network structure of the host population. Within a population there is a group of individuals, the core group, that maintains STI presence and helps sustain ongoing transmission both within the core group and in the surrounding population. While the presence of these core groups is well documented, the criteria for inclusion into a sexual core group is not. In this dissertation, I explore common factors that …

The Role Of Pharmacy In Supporting Safe And Effective Transitions Of Care, Laressa Bethishou

Pharmacy Faculty Articles and Research

Goal To inform pharmacists and pharmacy technicians of the importance of and processes for conducting transitions of care when patients are moving among healthcare settings.
Summary A narrative review of recent events and research into transitions of care (TOCs) — the movement of patients from one healthcare setting to another. To be conducted safely and effectively, the entire patient care team must optimize patient care and communicate up-to-date information among its members. As the medication experts on the healthcare team, pharmacists are well poised to receive and share information that impacts medication use and patient safety. Pharmacy technicians can play …

Impact Of Efavirenz On Hormone-Positive Breast Cancer Survival In Women Living With Hiv, Arthur T Johnson, Taolo Ntloedibe, Jose Euberto Mendez Reyes, Mogomotsi S Matshaba, Scott L Dryden-Peterson, Elizabeth Y Chiao

Center for Medical Ethics and Health Policy Staff Publications

Women living with HIV and breast cancer have poorer survival than HIV-negative women. Efavirenz-estrogen interactions are documented; however, the survival impact is unknown. Survival between women with estrogen-receptor positive breast cancer taking efavirenz (n = 38) and nonefavirenz regimens (n = 51) were compared. The 5-year overall-survival was 48.9% [95% confidence interval (CI) 33.0-72.2 and 51.1% (95% CI 34.0-76.8)] in the efavirenz and nonefavirenz groups, respectively suggesting efavirenz is unlikely driving poorer survival in women living with HIV and estrogen-receptor positive breast cancer.

No. 104 An Order Continuing The Asian Carp Advisory Commission, Bill Lee

Executive Orders

No abstract provided.

Gender Apartheid: Oppression Of Women Should Be Made A Crime Against Humanity – Feminist Academic Explains Why, Penelope Andrews

Other Publications

No abstract provided.

Langerhans Cell Histiocytosis: Nacho Update On Progress, Chaos, And Opportunity On The Path To Rational Cures, Simon Bomken, Patrick Campbell, Matthew Collin, Barbara Degar, Eli L Diamond, Olive S Eckstein, Nader El-Mallawany, Mark Fluchel, Gaurav Goyal, Michael M Henry, Michelle Hermiston, Michael Hogarty, Michael Jeng, Rima Jubran, Joseph Lubega, Ashish Kumar, Stephan Ladisch, Kenneth L Mcclain, Miriam Merad, Qing-Sheng Mi, D Williams Parsons, Erin Peckham-Gregory, Jennifer Picarsic, Zachary D Prudowsky, Barrett J Rollins, Peter H Shaw, Birte Wistinghausen, Carlos Rodriguez-Galindo, Carl E Allen, North American Consortium For Histiocytosis

Faculty, Staff and Students Publications

Langerhans cell histiocytosis (LCH) is a myeloid neoplastic disorder characterized by lesions with CD1a-positive/Langerin (CD207)-positive histiocytes and inflammatory infiltrate that can cause local tissue damage and systemic inflammation. Clinical presentations range from single lesions with minimal impact to life-threatening disseminated disease. Therapy for systemic LCH has been established through serial trials empirically testing different chemotherapy agents and durations of therapy. However, fewer than 50% of patients who have disseminated disease are cured with the current standard-of-care vinblastine/prednisone/(mercaptopurine), and treatment failure is associated with long-term morbidity, including the risk of LCH-associated neurodegeneration. Historically, the nature of LCH-whether a reactive condition versus …

Alexithymia Profiles And Depression, Anxiety, And Stress, David A. Preece, Ashish Mehta, Kate Petrova, Pilleriin Sikka, Ethan Pemberton, James J. Gross

Research outputs 2022 to 2026

Background: Alexithymia is a multidimensional trait comprised of difficulties identifying feelings, difficulties describing feelings, and externally orientated thinking. It is regarded as an important risk factor for emotional disorders, but there are presently limited data on each specific facet of alexithymia, or the extent to which deficits in processing negative emotions, positive emotions, or both, are important. In this study, we address these gaps by using the Perth Alexithymia Questionnaire (PAQ) to comprehensively examine the relationships between alexithymia and depression, anxiety, and stress symptoms. Methods: University students (N = 1250) completed the PAQ and the Depression Anxiety Stress Scales-21. Pearson …

Setd3 Is A Mechanosensitive Enzyme That Methylates Actin On His73 To Regulate Mitochondrial Dynamics And Function

Faculty, Staff and Students Publications

Mitochondria, which act as sensors of metabolic homeostasis and metabolite signaling, form a dynamic intracellular network that continuously changes shape, size and localization to respond to localized cellular energy demands. Mitochondrial dynamics and function depend on interactions with the F-actin cytoskeleton that are poorly understood. Here, we show that SET domain protein 3 (SETD3), a recently described actin histidine methyltransferase, directly methylates actin at histidine-73 and enhances F-actin polymerization on mitochondria. SETD3 is a mechano-sensitive enzyme that is localized on the outer mitochondrial membrane and promotes actin polymerization around mitochondria. SETD3 loss of function leads to diminished F-actin around mitochondria …

Associations Of Ambulatory Blood Pressure Measurements With High-Sensitivity Troponin And Natriuretic Peptide Levels In Sprint, Elaine Wu, Minjae Lee, Paul E Drawz, Vijay Nambi, Christie M Ballantyne, Anthony A Killeen, Joachim H Ix, Michael G Shlipak, Simon B Ascher

Faculty, Staff and Students Publications

Background: Nighttime blood pressure (BP) has greater prognostic importance for cardiovascular disease (CVD) than daytime BP, but less is known about nighttime and daytime BP associations with measures of subclinical CVD.

Methods: Among 897 Systolic Blood Pressure Intervention Trial Study (SPRINT) participants with 24-hour ambulatory BP monitoring obtained near the 27-month study visit, 849 (95%) had N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) measured at the 24-month study visit. Multivariable linear regression analyses were performed to evaluate the associations of nighttime and daytime BP with cardiac biomarker levels.

Results: The mean age was 69 ± 12 …

Pure Epidural Extraosseous Cavernous Hemangioma With Thoracic Myelopathy: Case Report And Review Of Literature, Jeffrey Chen, Jeffrey Treiber, Alfonso Fuentes

Faculty, Staff and Students Publications

Introduction: Pure epidural spinal cavernous hemangiomas are rare, benign vascular tumors that account for approximately 4% of all spinal epidural tumors. Due to their dumbbell shape and propensity for foraminal invasion, they are often misdiagnosed and inadequately treated. We present a case of a 58-year-old male with extra-osseous cavernous hemangioma to better aid in diagnosis and management of these lesions.

Case presentation: A 58-year-old male presented with chronic lower back pain, progressive lower extremity weakness, T10 sensory level, absent lower extremity proprioception, hyperreflexia, and an episode of bowel incontinence. Imaging demonstrated T7-T10 homogenous dorsal epidural mass causing cord signal change. …

That Is Just Scratching The Surface, Abdullah Niazi

Faculty Research - Newspaper and Magazine Articles

The Cabinet Committee on Implementation that was the precursor for the CCIR held 37 meetings from 23rd July, 2019 to 9th July, 2020. The purpose of this compilation is to Capture institutional memory in a systematic and coherent manner, to have readily available reference material and a guideline for follow up.

Establishing Updated Safety Standards For Independent (99)(M)Tc-Maa Spect/Ct Treatment Planning In Radioembolization, Taehyung Kim, Ripal Gandhi, Ranjini Tolakanahalli, Raul Herrera, Michael Chuong, Alonso Gutierrez, Diane Alvarez

All Publications

Purpose: Significant improvements within radioembolization imaging and dosimetry permit the development of an accurate and personalized pretreatment plan using technetium 99m-labeled macroaggregated albumin (99mTc-MAA) and single-photon emission computed tomography (SPECT) combined with anatomical CT (SPECT/CT). Despite these potential advantages, the clinical transition to pretreatment protocols with SPECT/CT is hindered by their unknown safety constraints. This study aimed to address this issue by establishing novel dose limits for 99mTc-MAA SPECT/CT to enable quantitative pretreatment planning.

Methods and materials: Stratification criteria to determine images most viable for dosimetry analysis were created from a cohort of 85 patients. SPECT/CT, cone beam CT, and …

Hypertensive Retinopathy As A Predictor Of Coronary Artery Disease In Elderly Hypertensive Patients With Angina Pectoris: A Comparative Study, Heba Abdulilah Ali Albayati, Firas Shanshal

Iraqi National Journal of Medicine

Background: In exploring novel avenues to assess cardiac health, this study investigates the potential of retinal vascular signs (RVS) as an effective tool for predicting coronary artery disease (CAD) in elderly hypertensive patients who present with angina pectoris. Considering the rising prevalence of cardiac disorders, there is an increasing interest in using noninvasive imaging modalities for early cardiovascular disease detection. This study conducts a comprehensive analysis to establish a direct correlation between retinal microvascular alterations and the development of heart disease in hypertensive patients. Methods: A total of 70 elderly hypertensive patients with acute angina underwent coronary angiograms and were …

Insight On Colonoscopy Findings In Southern Iraq: Retrospective Study From A Tertiary Center, Zeinab Kamil Dhahi, Loma Ahmed Al Mansory

Iraqi National Journal of Medicine

Background: Colonoscopy is the most trusted diagnostic tool in the screening and diagnosis of colorectal cancer and other colorectal diseases. Aim: This study intends to present the results of colonoscopic procedures carried out in Center for Digestive and Liver Disease and Surgery in Basrah Methods: Retrospective evaluation of 698 consecutive subjects who underwent screening or diagnostic colonoscopy at Basra Center for Liver Disease and Digestive System between 2014 and February 2020 was conducted. The primary outcome measure was the rate of adenoma detection, calculated alternately as the total number of detected neoplastic lesions divided by the number of subjects screened …

Outcome Of Endoscopic Cartilage Tympanoplasty In Anteriorly Extended Tympanic Membrane Perforation, Ahmed Fadhil Hasan, Amjed Hayder Ali Altaee, Saif Mohammed Hussein

Iraqi National Journal of Medicine

Background: The study was conducted to assess hearing improvement and graft uptake rate in patients with an anteriorly extended tympanic membrane perforation who underwent endoscopic cartilage tympanoplasty. Aim: The study aims to assess the efficacy of endoscopic cartilage tympanoplasty in repairing an anteriorly extended tympanic membrane perforation. Methods: A total of 135 patients aged between 10 and 63 years with an anteriorly extended tympanic membrane perforation were included in this study. Patients with an active middle ear disease and ossicular abnormality were excluded. Pure-tone audiometry was performed preoperatively at 500, 1000, 2000, and 4000 Hz, and the air-bone gap (ABG) …

Versatility Of Radial Artery Fascio-Cutaneous Free Flap For Head And Neck Reconstruction, Abdulrahman Miran, Rana Kamal Ibrahim

Iraqi National Journal of Medicine

Background: Reconstruction of the head and neck has made significant progress with the advent of microsurgery. The radial artery free flap is a workhorse flap in head and neck reconstruction due to its high-quality tissue that conforms to the complex and vital structures in this region. Aim: This study aims to assess the versatility and pliability of the radial artery free flap in the reconstruction of head and neck defects. Methods: A retrospective study was conducted over a six-year period (2017 to 2022) in Erbil, the capital of the Kurdistan region in Iraq, at Maryamana and PAR private hospitals. Twelve …

Comparative Analyses Of Immune Marker Levels In Seronegative And Seropositive Iraqi Rheumatoid Arthritis Patients, Ahmed Aledany, Eman Tariq Ali Altaee, Ali Nazar Mohammed, Falah Hassan Shari Alsukainy

Iraqi National Journal of Medicine

Background: Rheumatoid arthritis (RA) comprises an inflammation-based condition with a clinical phenotype that is mainly reliant on the occurrence of rheumatoid factor and anti-citrullinated protein antibodies. Literature indicates that seronegativity might be accompanied by higher severity of clinical symptoms, while higher disease activity, based on the recent classification criteria should also be associated with seronegativity. Aim: This investigation targets the identification of more efficient immune markers of RA seropositivity as well as examining the possibility that the latter is associated with lower severity. Methods: Serum samples from 128 RA patients, 106 seropositive and 22 seronegative, were analyzed using ELISA to …

Culturally Relevant Music Remedies For At-Risk Students, José Valentino Ruiz-Resto, Chris Shelton

Faculty Publications

This article presents a comprehensive review of the existing literature on the impact of social media on mental health. With the rapid growth and widespread adoption of social media platforms, concerns regarding their potential influence on individuals' psychological well-being have emerged. Drawing from a diverse range of studies, this review explores the various dimensions through which social media can affect mental health, including self-esteem, body image, loneliness, depression, anxiety, and addictive behaviors. The findings reveal both positive and negative outcomes, highlighting the complex relationship between social media use and mental health. Additionally, this article discusses the underlying mechanisms and potential …

The Patriarchal Framework Of Extreme Religious Cult Communities And The Post-Exit Affect On Families, Pamala M. Schievelbein

Masters Theses

The Lies We Keep is a screenplay about Pinnacle, a patriarchal cult community that employs mind control and narcotics to subjugate the women in the community. They follow a false religious doctrine and community framework that were created during the Victorian era when the Mormons migrated west and ended their culture of polygamy to avoid prosecution. This thesis brings to light the many facets of extreme religious cults and their daily lives within a controlling framework including specific gender roles, abuse, manipulation, and inequality. Government intervention and Freedom of Religion are also discussed in parallel to the Branch Davidians in …

Decision-Making Considering Power Consumption And Preference For New Energy Under Dual-Credit Policy, Fang Li, Tianhao Dong

Journal of System Simulation

Abstract: To explore the production decision-making problem of the electrification transformation in the domestic automobile industry faced by automobile manufacturers, different decision-making models under two production scenarios are constructed for the secondary supply chain composed of manufacturers and retailers under the background of a dual-credit policy. The electric energy consumption of new energy vehicles and consumers' preference for new energy are introduced. The Stackelberg game is applied to obtain the optimal production decision and income analysis of each member in the supply chain under different decision modes in different production scenarios. The results show that the in-depth implementation of the …

Specific Patterns Of Endogenous Functional Connectivity Are Associated With Harm Avoidance In Obsessive-Compulsive Disorder, Merage Ghane, Lucas Trambaiolli, Michele A Bertocci, Freddyson J Martinez-Rivera, Henry W Chase, Tyler Brady, Alex Skeba, Simona Graur, Lisa Bonar, Satish Iyengar, Gregory J Quirk, Steven A Rasmussen, Suzanne N Haber, Mary L Phillips

Faculty, Staff and Student Publications

Background: Individuals with obsessive-compulsive disorder (OCD) show persistent avoidance behaviors, often in the absence of actual threat. Quality-of-life costs and heterogeneity support the need for novel brain-behavior intervention targets. Informed by mechanistic and anatomical studies of persistent avoidance in rodents and nonhuman primates, our goal was to test whether connections within a hypothesized persistent avoidance-related network predicted OCD-related harm avoidance (HA), a trait measure of persistent avoidance. We hypothesized that 1) HA, not an OCD diagnosis, would be associated with altered endogenous connectivity in at least one connection in the network; 2) HA-specific findings would be robust to comorbid symptoms; …