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An American Nightmare: Ida B. Wells-Barnett And Gothic America, Jasper Dwaine St Bernard Ii Jul 2024

An American Nightmare: Ida B. Wells-Barnett And Gothic America, Jasper Dwaine St Bernard Ii

Electronic Theses and Dissertations Archive

This portfolio attempts, through the examination of her literary and social/political environment, to position Ida B. Wells-Barnett within the longer tradition of black writers who utilized the gothic to make sense of the black experience in America. It was through this means that these writers attempted to reflect back to this nation the horrific nature of black oppression. The first chapter interrogates where Wells-Barnett lands in this line. She was born toward the end of legal enslavement and came into her writing career during an era of racialized violence that many hoped, she argued, would reestablish, or maintain, the racial …


Research Support Services, Post Award Team, Research Management – Challenges, Aideen O'Byrne, Caroline Mcgowan Jul 2024

Research Support Services, Post Award Team, Research Management – Challenges, Aideen O'Byrne, Caroline Mcgowan

Research and Innovation - Other

In this presentation we outline some of the broad and specific challenges faced by TU Dublin's Research Support Services, Post Award team, when working with funded research projects.


Research Support Services, Post Award Team, Research Management – Best Practice, Aideen O'Byrne, Caroline Mcgowan Jul 2024

Research Support Services, Post Award Team, Research Management – Best Practice, Aideen O'Byrne, Caroline Mcgowan

Research and Innovation - Other

In this presentation we explain the Post Award services available within TU Dublin's Research Support Services, outlining a number of best practices for research management.


The Value Of Using Validated Competency-Based Assessments Across The Career Span Of An Athletic Trainer, Matthew Drescher, Lindsey Eberman Jul 2024

The Value Of Using Validated Competency-Based Assessments Across The Career Span Of An Athletic Trainer, Matthew Drescher, Lindsey Eberman

Clinical Practice in Athletic Training

No abstract provided.


Perceptions And Use Of The Athletic Training Milestones In Education: A Report From The Aate Research Network, Cailee E. Welch Bacon, Barton E. Anderson, Julie M. Cavallario, Bonnie L. Van Lunen, Lindsey E. Eberman Jul 2024

Perceptions And Use Of The Athletic Training Milestones In Education: A Report From The Aate Research Network, Cailee E. Welch Bacon, Barton E. Anderson, Julie M. Cavallario, Bonnie L. Van Lunen, Lindsey E. Eberman

Clinical Practice in Athletic Training

The Athletic Training Milestones (AT Milestones) were developed as an evaluation tool to capture the breadth and depth of athletic training knowledge, skills, and behavior. However, it is unclear whether athletic training programs are implementing this tool or how they are implementing it to gauge the clinical progression of students or residents in athletic training. We aimed to explore the perceptions and use of the AT Milestones among educators in athletic training programs. We used a cross-sectional, web- based survey with open-ended questions to collect data from athletic training programs on if and how they implement the AT Milestones at …


Standardized Patient Evaluation Tool: A Valid Measure Of The Core Competencies, Lindsey E. Eberman, Jessica Edler Nye Jul 2024

Standardized Patient Evaluation Tool: A Valid Measure Of The Core Competencies, Lindsey E. Eberman, Jessica Edler Nye

Clinical Practice in Athletic Training

No abstract provided.


The Development, Implementation, And Value Of The Athletic Training Milestones For Assessing Progressive Clinical Behaviors, Hollie Walusz, Eric Sauers, Mark Laursen, Forrest Pecha Jul 2024

The Development, Implementation, And Value Of The Athletic Training Milestones For Assessing Progressive Clinical Behaviors, Hollie Walusz, Eric Sauers, Mark Laursen, Forrest Pecha

Clinical Practice in Athletic Training

No abstract provided.


Mr. Joel Palmer Jul 2024

Mr. Joel Palmer

African American Funeral Programs

No abstract provided.


Activity: Students Find Conceptual Errors In Ai Output, Janie Brennan Jul 2024

Activity: Students Find Conceptual Errors In Ai Output, Janie Brennan

Generative AI Teaching Activities

Instructor asks ChatGPT questions related to a key concept to find one where ChatGPT has conceptual errors. Ask students to find the errors and explain them.


Nanoscale Mineral Formation At Environmental Interfaces, Ping-I Chou Jul 2024

Nanoscale Mineral Formation At Environmental Interfaces, Ping-I Chou

McKelvey School of Engineering Graduate Student Theses & Dissertations

Water scarcity represents a formidable challenge for human. Exponential population growth and industrial advancements further intensify the demand for potable water. Mineral nucleation at the nanoscale plays a central role in the strategic management of freshwater’s production and quality. In natural groundwater and surface water, the interactions between water and minerals, including earth-abundant iron (hydr)oxides and manganese (Mn) (hydr)oxides, control the mobilization and stabilization of heavy metals, harmful anions, and nutrients, thereby influencing water quality and environmental health. In an engineered context such as membrane desalination, the most widely utilized technique for desalinating seawater, the nucleation and growth of minerals …


Book Review: Skies Of Thunder: The Deadly World War Ii Mission Over The Roof Of The World, Heather Venable Jul 2024

Book Review: Skies Of Thunder: The Deadly World War Ii Mission Over The Roof Of The World, Heather Venable

Parameters Bookshelf – Online Book Reviews

Author: Caroline Alexander

Reviewed by Dr. Heather Venable, course director, Airpower Strategy and Operations, Air Command and Staff College

Dr. Heather Venable, course director, Airpower Strategy and Operations, at the Air Command and Staff College, insightfully analyzes multifaceted author and translator Caroline Alexander’s latest history of the China-Burma-India Theater. Venable overviews the book’s four main elements and the two structural topics—the “ ‘Hump’ of the Himalayas” and the land bridge. She praises the author’s “beguiling human and geographical detail” that “brings the CBI Theater to life while casting a critical eye on the human frailties of her research subjects.”


Book Review: Info Ops: From World War I To The Twitter Era, José De Arimatéia Da Cruz Jul 2024

Book Review: Info Ops: From World War I To The Twitter Era, José De Arimatéia Da Cruz

Parameters Bookshelf – Online Book Reviews

Editors: Ofer Fridman, Vitaly Kabernik, and Francesca Granelli

Reviewed by Dr. José de Arimatéia da Cruz, Department of Homeland Defense and Security Issues, Center for Strategic Leadership, US Army War College

Dr. José de Arimatéia da Cruz calls Info Ops a “must-read for any future combatant commander concerned about how our enemies use information and communication technologies within a contested environment to advance their causes and wreak havoc within an increasingly polarized society.” He overviews the book’s topics, including World War I and World War II, social media, Soviet Union propaganda, and even Israel and Hamas, and discusses their immediate …


Medicaid Coverage As A Critical Component In Care Coordination And Continuity In Health Care Access During Reentry For Justice-Involved Individuals In Maryland, Bernard Bendenkaga Alenda Jul 2024

Medicaid Coverage As A Critical Component In Care Coordination And Continuity In Health Care Access During Reentry For Justice-Involved Individuals In Maryland, Bernard Bendenkaga Alenda

Walden Dissertations and Doctoral Studies

Incarcerated individuals in the United States have a high disease burden. Moreover, most of them are released from incarceration without health coverage. The problem is that most incarcerated people in Maryland return to the community from incarceration without health coverage and cannot access health care. The purpose of this qualitative study was to understand how Medicaid enrollment staff and managers of the Medicaid program perceive the experiences and challenges of justice-involved individuals in navigating the Medicaid system in Maryland. The study was grounded in the behavioral model for vulnerable populations. The main research question aimed at understanding how the enrollment …


Exploration Of Therapists' Use Of Bibliotherapy As A Clinical Strategy For Military Children, Destiny Huff Jul 2024

Exploration Of Therapists' Use Of Bibliotherapy As A Clinical Strategy For Military Children, Destiny Huff

Walden Dissertations and Doctoral Studies

Military-connected children face unique life stressors related to their parents serving in the military. Therapists play an integral role in supporting these families. Specifically, research on therapists’ use of bibliotherapy as a clinical strategy to support these children’s needs is recommended. Bibliotherapy uses written material such as books, stories, and poems to address clients’ needs. The purpose of this interpretive descriptive qualitative study was to explore therapists’ use of bibliotherapy as a clinical strategy to address the unique stressors faced by military children ages 3-8 years old. Shrodes’s model of bibliotherapy was used as the theoretical framework. Data were collected …


Use Of A Community-Based Mentoring Program To Reduce Juvenile Delinquency And Crime In Adolescents, Andida Prince Jul 2024

Use Of A Community-Based Mentoring Program To Reduce Juvenile Delinquency And Crime In Adolescents, Andida Prince

Walden Dissertations and Doctoral Studies

The risk factors of juvenile delinquency and crime fail to acknowledge the systemic injustices, environmental stressors, and challenges youths bring to mentoring programs. Community-based mentoring programs are in place to assist with deterrence and reduction of juvenile delinquency and crime. The purpose of this qualitative study was to understand delinquency and crime in adolescents through the theoretical lens of social control theory. The goal was to explore the theories and understand what can be done to counteract the risk factors from the perspective of mentoring professionals. The research questions focused on community-based mentoring programs’ role in an adolescent’s life and …


Relationship Between Geographic Location, Race, And Socioeconomic Status On Adolescent Male Hpv Vaccination In The United States, Stacy Herb Jul 2024

Relationship Between Geographic Location, Race, And Socioeconomic Status On Adolescent Male Hpv Vaccination In The United States, Stacy Herb

Walden Dissertations and Doctoral Studies

Human papillomavirus (HPV) represents the most prevalent sexually transmitted infection in the United States. Despite readily available safe and effective vaccines and established knowledge of influencing factors, HPV vaccination rates in the United States remain suboptimal, particularly among adolescent males. This quantitative study addressed this gap by investigating the association between geographic location, race, and socioeconomic status with HPV vaccination uptake in adolescent males. A secondary data analysis was conducted using the 2022 National Immunization Survey (NIS)—Teen, comprised of 22,667 adolescent males. The fundamental cause theory served as the theoretical framework, guiding the exploration of why a safe and effective …


Association Of High Fibrinogen To Albumin Ratio With Long-Term Mortality In Patients With Spontaneous Intracerebral Hemorrhage, Shiping Chen, Yu Zhang, Yangchun Xiao, Xin Cheng, Liyuan Peng, Yixin Tian, Tiangui Li, Jialing He, Pengfei Hao, Weelic Chong, Yang Hai, Chao You, Fang Fang Jul 2024

Association Of High Fibrinogen To Albumin Ratio With Long-Term Mortality In Patients With Spontaneous Intracerebral Hemorrhage, Shiping Chen, Yu Zhang, Yangchun Xiao, Xin Cheng, Liyuan Peng, Yixin Tian, Tiangui Li, Jialing He, Pengfei Hao, Weelic Chong, Yang Hai, Chao You, Fang Fang

Department of Medical Oncology Faculty Papers

BACKGROUND: The association between fibrinogen-to-albumin ratio (FAR) and in-hospital mortality in patients with spontaneous intracerebral hemorrhage (ICH) has been established. However, the association with long-term mortality in spontaneous ICH remains unclear. This study aims to investigate the association between FAR and long-term mortality in these patients.

METHODS: Our retrospective study involved 3,538 patients who were diagnosed with ICH at West China Hospital, Sichuan University. All serum fibrinogen and serum albumin samples were collected within 24 h of admission and participants were divided into two groups according to the FAR. We conducted a Cox proportional hazard analysis to evaluate the association …


Auditor-Firm Conflict: Theoretical Concepts Application And Analysis Of The Power Dynamics Involved, Idowu Eferakeya Jul 2024

Auditor-Firm Conflict: Theoretical Concepts Application And Analysis Of The Power Dynamics Involved, Idowu Eferakeya

Journal of Accounting Auditing and Business

This study undertakes a theoretical analysis of the auditor-firm conflict. It relied on  the review of literature methodology  contextualized on  auditor’s appointment ,  firm economic pressure , management bargaining power, auditor’s fear of losing a firm, firm’s management economic power over the auditor, auditor’s personal attributes and moral reasoning, auditor’s tenure, audit fees, audit market competitiveness, non-audit services, audit firm size and the firm’s financial condition. The study relied on Goldman and Barlev model, exchange and dependency theories to explain the likely power positions in the auditor-firm relationship. Deductively the study based on the contexts indicated the presence of an …


Kindergarten Through Third-Grade Teachers’ Perceptions Of Implementing The Science Of Teaching Reading Practices, Shari Yvonne Ehly Jul 2024

Kindergarten Through Third-Grade Teachers’ Perceptions Of Implementing The Science Of Teaching Reading Practices, Shari Yvonne Ehly

Walden Dissertations and Doctoral Studies

In 2019, declines in reading achievement across Texas motivated changes for teacher recertification, which required 60-hour professional development in the science of teaching reading (STR). The problem this study addressed was the challenges K-Grade 3 reading teachers encountered when implementing the recently adopted Reading Academy content at a large urban school in Texas. The purpose of this basic qualitative project study was to explore the challenges K through Grade 3 reading teachers encountered when implementing the recently adopted Reading Academy content at a large urban school in Texas. The implementation science conceptual framework guided this study on the fidelity of …


Instrumental Variable And Colocalization Analyses Identify Endotrophin And Htra1 As Potential Therapeutic Targets For Coronary Artery Disease, Paul C Lee, In-Hyuk Jung, Shreeya Thussu, Ved Patel, Ryan Wagoner, Kendall H Burks, Junedh Amrute, Jared S Elenbaas, Chul Joo Kang, Erica P Young, Philipp E Scherer, Nathan O Stitziel Jul 2024

Instrumental Variable And Colocalization Analyses Identify Endotrophin And Htra1 As Potential Therapeutic Targets For Coronary Artery Disease, Paul C Lee, In-Hyuk Jung, Shreeya Thussu, Ved Patel, Ryan Wagoner, Kendall H Burks, Junedh Amrute, Jared S Elenbaas, Chul Joo Kang, Erica P Young, Philipp E Scherer, Nathan O Stitziel

2020-Current year OA Pubs

Coronary artery disease (CAD) remains a leading cause of disease burden globally, and there is a persistent need for new therapeutic targets. Instrumental variable (IV) and genetic colocalization analyses can help identify novel therapeutic targets for human disease by nominating causal genes in genome-wide association study (GWAS) loci. We conducted cis-IV analyses for 20,125 genes and 1,746 plasma proteins with CAD using molecular trait quantitative trait loci variant (QTLs) data from three different studies. 19 proteins and 119 genes were significantly associated with CAD risk by IV analyses and demonstrated evidence of genetic colocalization. Notably, our analyses validated well-established targets …


Bayesian Sequential Monitoring Strategies For Trials Of Digestive Cancer Therapeutics, Guillaume Mulier, Ruitao Lin, Thomas Aparicio, Lucie Biard Jul 2024

Bayesian Sequential Monitoring Strategies For Trials Of Digestive Cancer Therapeutics, Guillaume Mulier, Ruitao Lin, Thomas Aparicio, Lucie Biard

Faculty, Staff and Student Publications

Background: New therapeutics in oncology have presented challenges to existing paradigms and trial designs in all phases of drug development. As a motivating example, we considered an ongoing phase II trial planned to evaluate the combination of a MET inhibitor and an anti-PD-L1 immunotherapy to treat advanced oesogastric carcinoma. The objective of the paper was to exemplify the planning of an adaptive phase II trial with novel anti-cancer agents, including prolonged observation windows and joint sequential evaluation of efficacy and toxicity.

Methods: We considered various candidate designs and computed decision rules assuming correlations between efficacy and toxicity. Simulations were conducted …


Safety And Effectiveness Of Using Disposable Ultrasonic Shears To Coagulate 5–7 Mm Blood Vessels: Protocol For A Prospective, Multicenter, Randomized, Parallel Controlled, Non-Inferiority Clinical Trial, Xipeng Wang, Chengqiang Li, Junqiang Fan, Jian Hu, Mingsong Wang Jul 2024

Safety And Effectiveness Of Using Disposable Ultrasonic Shears To Coagulate 5–7 Mm Blood Vessels: Protocol For A Prospective, Multicenter, Randomized, Parallel Controlled, Non-Inferiority Clinical Trial, Xipeng Wang, Chengqiang Li, Junqiang Fan, Jian Hu, Mingsong Wang

Faculty, Staff and Student Publications

BACKGROUND: The ultrasonic scalpel is widely used during surgery. It is safe and effective to close the pulmonary artery branch vessels of 7 mm or below with an ultrasonic energy device as reported. However, there have been no multicenter randomized clinical trial to assess the safety and effectiveness of using ultrasonic scalpel to coagulate 5-7 mm blood vessels in thoracic surgery.

METHODS: This is a prospective, multicenter, randomized, parallel controlled, non-inferiority clinical trial. A total of 144 eligible patients planning to undergo lung or esophageal surgery will be randomly allocated to the experimental group and the control group. The investigational …


Exploration Of A Potential Door Endpoint For Hospital-Acquired Bacterial Pneumonia And Ventilator-Associated Bacterial Pneumonia Using Six Registrational Trials For Antibacterial Drugs, Tori Kinamon, Ursula Waack, Mark Needles, Daniel Rubin, Deborah Collyar, Scott R Evans, Thomas L Holland, Jessica Howard-Anderson, Henry Chambers, Vance G Fowler, Sumati Nambiar, Peter Kim, Helen W Boucher, Ramya Gopinath Jul 2024

Exploration Of A Potential Door Endpoint For Hospital-Acquired Bacterial Pneumonia And Ventilator-Associated Bacterial Pneumonia Using Six Registrational Trials For Antibacterial Drugs, Tori Kinamon, Ursula Waack, Mark Needles, Daniel Rubin, Deborah Collyar, Scott R Evans, Thomas L Holland, Jessica Howard-Anderson, Henry Chambers, Vance G Fowler, Sumati Nambiar, Peter Kim, Helen W Boucher, Ramya Gopinath

Faculty, Staff and Student Publications

BACKGROUND: Desirability of outcome ranking (DOOR) is an innovative approach to clinical trial design and analysis that uses an ordinal ranking system to incorporate the overall risks and benefits of a therapeutic intervention into a single measurement. Here we derived and evaluated a disease-specific DOOR endpoint for registrational trials for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP).

METHODS: Through comprehensive examination of data from nearly 4000 participants enrolled in six registrational trials for HABP/VABP submitted to the Food and Drug Administration (FDA) between 2005 and 2022, we derived and applied a HABP/VABP specific endpoint. We estimated the probability that …


Interlaboratory Comparison Of Branched Gdgt Temperature And Ph Proxies Using Soils And Lipid Extracts, Brgdgts Round Robin, Cindy De Jonge, Francien Peterse, Klaas G.J. Nierop, Thomas M. Blattmann, Marcelo Alexandre, Salome Ansanay-Alex, Thomas Austin, Mathieu Babin, Edouard Bard, Thorsten Bauersachs, Jerome Blewett, Brenna Boehman, Isla S. Castañeda, Junhui Chen, Martina L.G. Conti, Sergio Contreras, Julia Cordes, Nina Davtian, Bart Van Dongen, Bella Duncan, Felix J. Elling, Valier Galy, Shaopeng Gao, Jens Hefter, Kai Uwe Hinrichs, Mitchell R. Helling, Mariska Hoorweg, Ellen Hopmans, Arnaud Huguet, Guodong Jia, Cornelia Karger, Brendan J. Keely, Stephanie Kusch, Hui Li, Jie Liang, Julius S. Lipp, Weiguo Liu, Hongxuan Lu, Kai Mangelsdorf, Hayley Manners, Alfredo Martinez Garcia, Guillemette Menot, Gesine Mollenhauer, B. David A. Naafs, Sebastian Naeher, Lauren K. O'Connor, Ethan M. Pearce, Ann Pearson Jul 2024

Interlaboratory Comparison Of Branched Gdgt Temperature And Ph Proxies Using Soils And Lipid Extracts, Brgdgts Round Robin, Cindy De Jonge, Francien Peterse, Klaas G.J. Nierop, Thomas M. Blattmann, Marcelo Alexandre, Salome Ansanay-Alex, Thomas Austin, Mathieu Babin, Edouard Bard, Thorsten Bauersachs, Jerome Blewett, Brenna Boehman, Isla S. Castañeda, Junhui Chen, Martina L.G. Conti, Sergio Contreras, Julia Cordes, Nina Davtian, Bart Van Dongen, Bella Duncan, Felix J. Elling, Valier Galy, Shaopeng Gao, Jens Hefter, Kai Uwe Hinrichs, Mitchell R. Helling, Mariska Hoorweg, Ellen Hopmans, Arnaud Huguet, Guodong Jia, Cornelia Karger, Brendan J. Keely, Stephanie Kusch, Hui Li, Jie Liang, Julius S. Lipp, Weiguo Liu, Hongxuan Lu, Kai Mangelsdorf, Hayley Manners, Alfredo Martinez Garcia, Guillemette Menot, Gesine Mollenhauer, B. David A. Naafs, Sebastian Naeher, Lauren K. O'Connor, Ethan M. Pearce, Ann Pearson

School of Geography, Earth and Environmental Sciences

Ratios of glycerol dialkyl glycerol tetraethers (GDGT), which are membrane lipids of bacteria and archaea, are at the base of several paleoenvironmental proxies. They are frequently applied to soils as well as lake- and marine sediments to generate records of past temperature and soil pH. To derive meaningful environmental information from these reconstructions, high analytical reproducibility is required. Based on submitted results by 39 laboratories from across the world, which employ a diverse range of analytical and quantification methods, we explored the reproducibility of brGDGT-based proxies (MBT′5ME, IR, and #ringstetra) measured on four soil samples and …


Tissue-Specific Effects Of Temperature And Salinity On The Cell Cycle And Apoptosis In The Nile Tilapia (Oreochromis Niloticus)., Rachel M. Palmer, Arika Sandbach, Bradley A. Buckley Jul 2024

Tissue-Specific Effects Of Temperature And Salinity On The Cell Cycle And Apoptosis In The Nile Tilapia (Oreochromis Niloticus)., Rachel M. Palmer, Arika Sandbach, Bradley A. Buckley

Biology Faculty Publications and Presentations

The Nile Tilapia (Oreochromis niloticus) evolved in warm, freshwater rivers, but possesses a broad physiological tolerance to a range of environmental conditions. Due to this hardiness and resilience, this species has been successfully introduced to regions widely outside of its native range. Here, we examine the impact of temperature and salinity variation on this species at the sub-lethal level. Specifically, Nile Tilapia were exposed to two temperatures (21 °C or 14 °C) and three salinities (0, 16, 34 ppt) for 1-h. Given their native habitat, the 21 °C / 0 ppt exposure was considered the control condition. Both cell cycle …


Targeted Co-Expression Networks For The Study Of Traits, A Gómez-Pascual, G Rocamora-Pérez, L Ibanez, J A Botía Jul 2024

Targeted Co-Expression Networks For The Study Of Traits, A Gómez-Pascual, G Rocamora-Pérez, L Ibanez, J A Botía

2020-Current year OA Pubs

Weighted Gene Co-expression Network Analysis (WGCNA) is a widely used approach for the generation of gene co-expression networks. However, networks generated with this tool usually create large modules with a large set of functional annotations hard to decipher. We have developed TGCN, a new method to create Targeted Gene Co-expression Networks. This method identifies the transcripts that best predict the trait of interest based on gene expression using a refinement of the LASSO regression. Then, it builds the co-expression modules around those transcripts. Algorithm properties were characterized using the expression of 13 brain regions from the Genotype-Tissue Expression project. When …


Working (Around/Within/Against) Prior Appropriation: Diverse Hydrosocial Practices To Secure Water For Rivers, Alida Cantor, Jillian Farley, Thien-Kim Bui, Zachary Boyce Jul 2024

Working (Around/Within/Against) Prior Appropriation: Diverse Hydrosocial Practices To Secure Water For Rivers, Alida Cantor, Jillian Farley, Thien-Kim Bui, Zachary Boyce

Geography Faculty Publications and Presentations

Water scarcity in the Western US, through the lens of political ecology, can be understood as inextricably shaped by power dynamics, governance structures, and legal practices of resource allocation. Water allocation in the region is determined largely by the legal doctrine of Prior Appropriation, the 'first in time, first in right' principle. However, prior appropriation is fundamentally based in anthropocentric and settler colonial assumptions, and in light of drought, climate change, and shifting social and environmental values, the system has been critiqued as inadequate to meet contemporary water challenges. Despite challenging historical legacies, water managers in the Western US are …


Trackins (Trk-Targeting Drugs): A Novel Therapy For Different Diseases, George N Chaldakov, Luigi Aloe, Stanislav G Yanev, Marco Fiore, Anton B Tonchev, Manlio Vinciguerra, Nikolai T Evtimov, Peter Ghenev, Krikor Dikranian Jul 2024

Trackins (Trk-Targeting Drugs): A Novel Therapy For Different Diseases, George N Chaldakov, Luigi Aloe, Stanislav G Yanev, Marco Fiore, Anton B Tonchev, Manlio Vinciguerra, Nikolai T Evtimov, Peter Ghenev, Krikor Dikranian

2020-Current year OA Pubs

Many routes may lead to the transition from a healthy to a diseased phenotype. However, there are not so many routes to travel in the opposite direction; that is, therapy for different diseases. The following pressing question thus remains: what are the pathogenic routes and how can be they counteracted for therapeutic purposes? Human cells contain >500 protein kinases and nearly 200 protein phosphatases, acting on thousands of proteins, including cell growth factors. We herein discuss neurotrophins with pathogenic or metabotrophic abilities, particularly brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), pro-NGF, neurotrophin-3 (NT-3), and their receptor Trk (tyrosine receptor …


Whole Cervix Imaging Of Collagen, Muscle, And Cellularity In Term And Preterm Pregnancy, Wenjie Wu, Zhexian Sun, Hansong Gao, Yuan Nan, Stephanie Pizzella, Haonan Xu, Josephine Lau, Yiqi Lin, Hui Wang, Pamela K Woodard, Hannah R Krigman, Qing Wang, Yong Wang Jul 2024

Whole Cervix Imaging Of Collagen, Muscle, And Cellularity In Term And Preterm Pregnancy, Wenjie Wu, Zhexian Sun, Hansong Gao, Yuan Nan, Stephanie Pizzella, Haonan Xu, Josephine Lau, Yiqi Lin, Hui Wang, Pamela K Woodard, Hannah R Krigman, Qing Wang, Yong Wang

2020-Current year OA Pubs

Cervical softening and dilation are critical for the successful term delivery of a fetus, with premature changes associated with preterm birth. Traditional clinical measures like transvaginal ultrasound and Bishop scores fall short in predicting preterm births and elucidating the cervix's complex microstructural changes. Here, we introduce a magnetic resonance diffusion basis spectrum imaging (DBSI) technique for non-invasive, comprehensive imaging of cervical cellularity, collagen, and muscle fibers. This method is validated through ex vivo DBSI and histological analyses of specimens from total hysterectomies. Subsequently, retrospective in vivo DBSI analysis at 32 weeks of gestation in ten term deliveries and seven preterm …


Quality Assessment Of Life Cycle Inventory Data For Fibre-Reinforced Polymer Composite Materials, Badr Moutik, John Summerscales, Jasper Graham-Jones, Richard Pemberton Jul 2024

Quality Assessment Of Life Cycle Inventory Data For Fibre-Reinforced Polymer Composite Materials, Badr Moutik, John Summerscales, Jasper Graham-Jones, Richard Pemberton

School of Engineering, Computing and Mathematics

Composite industry growth, driven by the demand for lightweight and high-performance structures, has intensified challenges and inquiries regarding its lifecycle environmental impact, catalysing an increase in Life Cycle Assessment (LCA) studies. These studies have revealed significant concerns about the quality and reliability of Life Cycle Inventory (LCI) data, highlighting the risk of inaccuracies that could undermine LCA outcomes and produce misleading conclusions. This situation underscores the critical need for stringent data quality assurance. This study aims to critically assess LCI data quality for composite materials to enhance reliability and utility of LCA in promoting sustainable industry development. Objectives include reviewing …