Digital Commons Network^™

Targeting Igf2 To Reprogram The Tumor Microenvironment For Enhanced Viro-Immunotherapy, Min Hye Noh, Jin Muk Kang, Alexandra A Miller, Grace Nguyen, Minxin Huang, Alberto J Bueso-Perez, Kimberly A Rivera-Caraballo, Yoshihiro Otani, Eunju Kim, Seung-Hee Yoo, Yuanqing Yan, Yeshavanth Banasavadi-Siddegowda, Hiroshi Nakashima, E Antonio Chiocca, Balveen Kaur, Zhongming Zhao, Tae Jin Lee, Ji Young Yoo

Faculty, Staff and Student Publications

BACKGROUND: The FDA approval of oncolytic herpes simplex-1 virus (oHSV) therapy underscores its therapeutic promise and safety as a cancer immunotherapy. Despite this promise, the current efficacy of oHSV is significantly limited to a small subset of patients largely due to the resistance in tumor and tumor microenvironment (TME).

METHODS: RNA sequencing (RNA-Seq) was used to identify molecular targets of oHSV resistance. Intracranial human and murine glioma or breast cancer brain metastasis (BCBM) tumor-bearing mouse models were employed to elucidate the mechanism underlying oHSV therapy-induced resistance.

RESULTS: Transcriptome analysis identified IGF2 as one of the top-secreted proteins following oHSV treatment. …

Implementation Of A Dyadic Nomenclature For Monogenic Diseases, Courtney Thaxton, Leslie G Biesecker, Marina Distefano, Melissa Haendel, Ada Hamosh, Emma Owens, Sharon E Plon, Heidi L Rehm, Jonathan S Berg

Center for Medical Ethics and Health Policy Staff Publications

A core task when establishing the strength of evidence for a gene's role in a monogenic disorder is determining the appropriate disease entity to curate. Establishing this concept determines which evidence can be applied and quantified toward the final gene-disease validity, variant pathogenicity, or actionability classification. Genes with implications in more than one phenotype can necessitate a process of lumping and splitting, disease reorganization, and updates to disease nomenclature. Reappraisal of the names that are used as labels for disease entities is therefore a necessary and perpetual process. The Clinical Genome Resource (ClinGen), in collaboration with representatives from Monarch Disease …

Assessing Nurse Educators' Competencies For Adopting Blended Learning In The Skills Labs In Uganda's Public Nursing Schools, Eva Kakonge Nampiima, Mathias M Bwanika Ulumba, Musisi Badru, Grace Nakate

School of Nursing & Midwifery, East Africa

Blended learning has become an integral part of nursing education, offering a blend of online and face-to-face instruction that enhances learning experiences, particularly within skills labs. However, the effectiveness of blended learning largely depends on the competencies of nurse educators in utilizing digital tools and methodologies. This study assessed the competencies of nurse educators in Uganda's public nursing schools concerning blended learning adoption. Data was collected from 40 randomly selected nursing educators in 4 public nursing schools in Uganda. The findings indicate significant inadequacies: only 25% are proficient with Learning Management Systems (LMS) like Moodle, 20% can effectively use platforms …

Prospective Exploratory Evaluation Of Cepheid Xpert Mycobacterium Tuberculosis Host Response Cartridge: A Focus On Adolescents And Young Adults, Marva Seifert, Donald G. Catanzaro, Michael Gracia, Naomi Hillery, Sabira Tahseen, Faisal Masood, Uzma Majeed, Rebecca E. Colman, Rehan Syed, Antonino Catanzaro, Timothy Rodwell

Biological Sciences Faculty Publications and Presentations

Background. An accurate, rapid, non-sputum-based triage test for diagnosing tuberculosis (TB) is needed. Methods. A prospective evaluation of the Cepheid GeneXpert Mycobacterium tuberculosis Host Response cartridge (Xpert- MTB-HR), a prototype blood-based host response mRNA signature assay, among individuals presenting with TB-like symptoms was performed in Pakistan and results were compared to 3 reference standards: Xpert MTB/RIF Ultra, bacteriological confirmation (Xpert MTB/RIF Ultra and/or culture positivity), and composite clinical diagnosis (clinician diagnosis, treatment initiation, Xpert MTB/RIF Ultra, and/or culture positivity). Analyses were conducted both for the entire study cohort and separately in the adolescent and young adult cohort (aged 10–24 years). …

Stat3-Mediated Atg7 Expression Regulates Anti-Tumor Immunity In Mouse Melanoma, Sarah M Zimmerman, Erin Suh, Sofia R Smith, George P Souroullas

2020-Current year OA Pubs

Epigenetic modifications to DNA and chromatin control oncogenic and tumor-suppressive mechanisms in melanoma. Ezh2, the catalytic component of the Polycomb Repressive Complex 2 (PRC2), which mediates methylation of lysine 27 on histone 3 (H3K27me3), can regulate both melanoma initiation and progression. We previously found that mutant Ezh2

Efficacy Of Parp Inhibitor Therapy After Targeted Braf/Mek Failure In Advanced Melanoma, Jordan Phillipps, George Nassief, Renee Morecroft, Tolulope Adeyelu, Andrew Elliott, Farah Abdulla, Ari Vanderwalde, Soo Park, Omar Butt, Alice Zhou, George Ansstas

2020-Current year OA Pubs

Modern advancements in targeted therapy and immunotherapy have significantly improved survival outcomes for advanced melanoma; however, there remains a need for novel approaches to overcome disease progression and treatment resistance. In recent years, PARPi therapy has shown great promise both as a single regimen and in combination with other therapeutics in melanoma. Here, we describe three unique cases of advanced BRAF V600 mutated melanoma that progressed on targeted BRAF/MEK agents that subsequently exhibited partial to near-complete responses to combinatory PARPi and BRAF/MEK inhibitors. This highlights both a potential synergy underlying this combinatory approach and its efficacy as a treatment option …

Judicial Preview Oleh Mahkamah Konstitusi Sebagai Upaya Preventif Perlindungan Hak Konstitusional (Studi Komperasi Dengan Mahkamah Konstitusi Chili), Elisabeth Sihaloho, Fifiana Wisnaeni

Jurnal Hukum & Pembangunan

The existence of the Constitutional Court as stated in the provisions of Article 24C of the 1945 Constitution has established the dignity of the Constitutional Court's position as a Guardian of the Constitution which is understood as a judicial institution that protects the constitutional rights of Indonesia citizens. This research is aimed at solving the problem of the constitutional rights of Indonesia citizens who are often injured through legal products in the form of laws. Therefore, this study focuses on studying, analyzing and comparing how the context of judicial preview or can be understood as a test of a draft …

Arbitrase Dan Media Sosial (Arbitration And Social Media), Suar Sanubari

Jurnal Hukum & Pembangunan

This article discusses the use of social media among arbitration actors. Social media have evolved since its inception. In the beginning, social networks were used to stay in touch with friends and family. Now the trend is to follow influencers. The boundaries between personal and professional use have become blurry. Social media are more regulated and supervised now, especially due to privacy and national security concerns. The social media adoption landscape has matured with increasing adoption by all generations. The use of social media can give rise to questions about ethical conduct or even the integrity of the arbitration proceedings. …

Kenyon Collegian - September 5, 2024

The Kenyon Collegian

No abstract provided.

Rural Adolescent Attitudes And Use Of Helmets While Riding Atvs, Motorcycles And Dirt Bikes, Charles A. Jennissen, Sehansa R. Karunatilaka, Brianna J. Iverson, Devin E. Spolsdoff, Kristel M. Wetjen, Brenda Vergara, Shannon R. Landers, Pam J. Hoogerwerf

Student Publications

Background: Head injuries are the most common cause of death in some motorized vehicles for which helmet use can significantly decrease the risk. Our objective was to determine rural adolescents' attitudes regarding helmets and their use while riding ATVs, motorcycles and dirt bikes.

Methods: A convenience sample of 2022 Iowa FFA (formerly Future Farmers of America) Leadership Conference attendees were surveyed. After compilation, data were imported into the statistical program, R ( https://www.R-project.org/ ). Descriptive statistics, contingency table, logistic regression and non-parametric alternatives to ANOVA analyses were performed.

Results: 1331 adolescents (13-18 years) participated. One half lived on a farm, …

Speechmatch—A Novel Digital Approach To Supporting Communication For Neurodiverse Groups, Rohit Shankar

Peninsula Medical School

Communication can be a challenge for a significant minority of the population. Those with intellectual disability, autism, or Stroke survivors can encounter significant problems and stigma in their communication abilities leading to worse health and social outcomes. SpeechMatch (https://www.speechmatch.com/) is a digital App which is a pragmatic mobile language training platform that teaches individuals to “match” critical components of conversation and looks to provides subjects with immediate visual feedback to shape identification and expression of emotion in speech. While it has been used in autistic people there has been no systematic exploration of its strengths and weaknesses. Further, it's potential …

Regional Desynchronization Of Microglial Activity Is Associated With Cognitive Decline In Alzheimer's Disease, Artem Zatcepin, Samira Parhizkar, Et Al.

2020-Current year OA Pubs

BACKGROUND: Microglial activation is one hallmark of Alzheimer disease (AD) neuropathology but the impact of the regional interplay of microglia cells in the brain is poorly understood. We hypothesized that microglial activation is regionally synchronized in the healthy brain but experiences regional desynchronization with ongoing neurodegenerative disease. We addressed the existence of a microglia connectome and investigated microglial desynchronization as an AD biomarker.

METHODS: To validate the concept, we performed microglia depletion in mice to test whether interregional correlation coefficients (ICCs) of 18 kDa translocator protein (TSPO)-PET change when microglia are cleared. Next, we evaluated the influence of dysfunctional microglia …

[Discussions] Vol. 15 Iss. 2

Discussions

No abstract provided.

Societal Evolution: Descent Of Man, Chapter V And The Myth Of Progress, Jakob Hanschu

Discussions

No abstract provided.

Faculty Spotlight: Dr. Patricia Princehouse, Christopher Carr

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[Discussions] Vol. 15 Iss. 1

Discussions

No abstract provided.

A Comparative Analysis Of Media Responses To 1918-1919 Influenza Pandemic In Cleveland Oh, And St.Louis, Mo, Tarun Jella

Discussions

No abstract provided.

The International Legal Personality Of Non-State Armed Groups, Desiree Van Iersel

Discussions

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Faculty Spotlight: Dr. Paul Iversen, Ryan Tatton

Discussions

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[Discussions] Vol. 14 Iss. 4

Discussions

No abstract provided.

Euthanasia: A Cross-Cultural Analysis Of Right-To-Die Organzations And Euthanasia Legislature In The Netherlands And United States, Anjana Renganathan

Discussions

No abstract provided.

An Analysis Of Vaccine Hesitancy In The United States: Contributing Factors And Healthcare Response, Hannah Kent

Discussions

No abstract provided.

Exploring The Differences Between Bilinguals And Monolinguals In Non-Communicative Spatial Perspective-Taking Tasks, Shira Yellin

Discussions

No abstract provided.

Faculty Spotlight: Dr. Lee Hoffer, Viral Mistry

Discussions

No abstract provided.

[Discussions] Vol. 13 Iss. 3

Discussions

No abstract provided.

Flight Of The Eagle: Kawanabe Kyosai And His Influences, Jaques Gillis

Discussions

No abstract provided.

The Downside Of The Economic Miracle: China’S Economic Reform And The Increase In Sex Trafficking, Alexandra Sakellariou

Discussions

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Force Dynamics In Political Discourse, Lauren Lucente

Discussions

No abstract provided.

Re-Fashioning The Field: On Gender And Computer Science, Jessica Nash

Discussions

No abstract provided.

Faculty Spotlight: Dr. Jessica Fox

Discussions

No abstract provided.