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Articles 33871 - 33900 of 5206397
Full-Text Articles in Entire DC Network
Back Cover, Taylor-Dawn Francis
Constitutional Inferences On Emerging Technologies: Analyzing Government Overreach, The Fourth Amendment, And Democratic Process In The Age Of Artificial Intelligence, Alan To
McNair Research Journal SJSU
The rapid adoption of artificial intelligence (AI) and machine learning (ML)
technologies by federal agencies presents novel constitutional questions that
existing legal doctrine has not yet adequately addressed. This paper
examines the emerging constitutional dimensions of the 2026 conflict
between Anthropic and the Department of Defense (DOD), in which the
Pentagon demanded unrestricted use of Anthropic's AI model Claude for
domestic mass surveillance and autonomous weapons systems, ultimately
designating Anthropic a supply chain risk when the company refused.
Drawing on three salient constitutional frameworks, specifically the Fourth
Amendment doctrine established in Kyllo v. United States (2001) and
Carpenter v. United …
Words Can Hurt: A Review Of Racial Microaggressions And Their Effects On Cortisol Level, Edgar Perez-Lopez
Words Can Hurt: A Review Of Racial Microaggressions And Their Effects On Cortisol Level, Edgar Perez-Lopez
McNair Research Journal SJSU
The study examines the impact of racial microaggressions on cortisol levels,
highlighting inconsistent findings across various research methodologies.
Microaggressions--subtle discriminatory actions--are linked to stress and
can raise cortisol levels, a hormone released in response to stress. Some
studies suggest that frequent microaggressions blunt cortisol response,
making it less available for future stressors, while others reported increased
cortisol levels. The divergence in results may be due to differences in
research designs, such as cross-sectional, interpersonal research, or
nomothetic, versus longitudinal, intrapersonal research, or idiographic
approaches. Combined, the results of each type of research proves chronic
and acute impact of microaggressions. The …
Platonic Affection, Philia, And Trans-Philosophy, Kai Parker
Platonic Affection, Philia, And Trans-Philosophy, Kai Parker
McNair Research Journal SJSU
In this article, I review the heteronormative social conventions of cisgender
men and women's abilities to build and maintain friendships vis-.vis
traditional Western gender roles. It divides the philosophical concept of
Plato’s “platonic love” as fully realized Eros from the basic social
interpretation of “platonic” relationships as connections devoid of sexual or
romantic feelings. Aristotle's definitions of friendship, divided into the three
categories of pleasure, utility, and virtue, are compared to friendships
cisgender men and women form with others of the same orientation. Men's
friendships are found to more often fall into friendships of utility and
pleasure, while women's friendships …
The Relationship Between Gender, Platonic Physical Affection, And Interpersonal Sensitivity, Mariam Malik
The Relationship Between Gender, Platonic Physical Affection, And Interpersonal Sensitivity, Mariam Malik
McNair Research Journal SJSU
Interpersonal sensitivity (IS), also known as emotional maturity or empathy,
is characterized by recognizing emotions and displaying empathy, which
are important social skills. Understanding the factors that are associated
with interpersonal sensitivity can provide the foundation for research
revolving around improving interpersonal sensitivity, and in turn,
improving social skills. Platonic physical affection (PPA), such as holding
hands and hugging, is a social variable often associated with those close to
one another (e.g., friends and family). However, the exhibition and
receptivity to this social variable may differ across cultures and genders.
This study aimed to see if there is a relationship …
Front Matter, Maria Cruz
Bridging Interprofessional Gaps: A Pilot Study On Aac And Asl Training For Allied Health Profession Students, Angela M. Riccelli, Danielle Osmelak, Leslie Guca, Keith Werosh, Valerie Coolman, Rebecca Kvasnicka
Bridging Interprofessional Gaps: A Pilot Study On Aac And Asl Training For Allied Health Profession Students, Angela M. Riccelli, Danielle Osmelak, Leslie Guca, Keith Werosh, Valerie Coolman, Rebecca Kvasnicka
Journal of Applied Disciplines
Interprofessional education (IPE) is recognized as a critical component of health professions training, equipping future clinicians with the skills necessary for collaborative practice and patient-centered care. However, students in speech-language pathology, occupational therapy, and physical therapy programs often have limited exposure to individuals who rely on Augmentative and Alternative Communication (AAC) or American Sign Language (ASL). This study evaluated the impact of a grant-funded, AAC- and ASL-focused IPE event at Governors State University on students’ self-reported interprofessional competencies. Using the Interprofessional Collaborative Competencies Attainment Survey (ICCAS-R) developed by Archibald, D., Trumpower, D., and MacDonald, C.J., in 2009 and revised in …
The Art Of Martin Wong, And The Traditions He Drew From, Janie Mendosa
The Art Of Martin Wong, And The Traditions He Drew From, Janie Mendosa
IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt
Martin Wong was a singular figure in the art world, drawing from diverse influences including Pan-Asian traditions, Western modernism, social realism, and the emerging graffiti movement. As a queer artist who lived in urban New York City to San Francisco's Chinatown, he existed on the margins.
Refining A Flow Injection Analysis Method For Trace Concentrations Of Iron In Seawater, Brooke I. Stafford, Liam W. Hodgson, Noah S. Schuhmann, Elijah J. Vestal, Claire P. Till
Refining A Flow Injection Analysis Method For Trace Concentrations Of Iron In Seawater, Brooke I. Stafford, Liam W. Hodgson, Noah S. Schuhmann, Elijah J. Vestal, Claire P. Till
IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt
Iron is an essential micronutrient required for the growth of phytoplankton, the base of the oceanic food chain. Iron exists in the ocean in extremely low concentrations, limiting primary productivity in ~⅓ of the surface ocean, and can be affected by physical processes such as upwelling of water masses, and by biological and chemical processes within the water. In order to further our understanding of iron availability in the ocean, here we refine and improve our understanding of an analytical method to measure nanomolar iron in seawater. The method used is an adaptation of Lohan et al. (2006), a flow …
Interrogating Settler Narratives Of Erasure In The Schatz Tree Farm Archives, Sangeeta Sarkar
Interrogating Settler Narratives Of Erasure In The Schatz Tree Farm Archives, Sangeeta Sarkar
IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt
In 1987, L. W. Schatz donated a 385-acre parcel of land to Cal Poly Humboldt to be used as an experimental station, outdoor classroom, and demonstration area for forestry educators and students. Previous student research and other institutional narratives have extensively documented the history of this land from a settler perspective. However, this documentation contains few mentions of the Indigenous history of the landscape. Through literature review and archival research, this paper critically analyzes settler colonial narratives around the Schatz Tree Farm and the ways in which they contribute to Indigenous erasure. The predominant forms of narrative erasure in settler …
Exploring The Relationship Between Tree Dbh And Lichen Cover On Coast Redwood, Grace M. Personeus, Sierra Gittleman, Alisa A. Zarattini
Exploring The Relationship Between Tree Dbh And Lichen Cover On Coast Redwood, Grace M. Personeus, Sierra Gittleman, Alisa A. Zarattini
IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt
We investigated the relationship between Diameter at Breast Height (DBH) and lichen cover on coast redwood (Sequoia sempervirens) to see if larger trees had higher percentages of cover. We measured cover using 10 cover classes on the southeastern and southwestern sides of trees in a secondary growth forest. We found a significant relationship between DBH and cover, yet no significant difference between the two sides measured. We suggest that further research with a larger sample size and more varied age classes will provide further insight into the relationship.
Allosteric And Uncompetitive Inhibition Of Yeast Alcohol Dehydrogenase Identified By Enzyme Kinetics, Dylan Jeremy Harrison, Jenny A. Cappuccio
Allosteric And Uncompetitive Inhibition Of Yeast Alcohol Dehydrogenase Identified By Enzyme Kinetics, Dylan Jeremy Harrison, Jenny A. Cappuccio
IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt
Enzyme kinetics is a powerful technique used to quantify the rate at which an enzyme converts a substrate into a product and to identify potential inhibitors. In this study, kinetic analysis was employed to assess the activity of yeast alcohol dehydrogenase (YADH) in the presence and absence of sweeteners commonly found in alcoholic beverages. YADH catalyzes the oxidation of ethanol to acetaldehyde using NAD⁺ as a cofactor; the reduction to NADH can be monitored spectrophotometrically at 340 nm. Based on structural similarities to the ribose moiety of NAD⁺, it was hypothesized that sucrose and sucralose could directly interact with the …
Full Issue, The Press At Cal Poly Humboldt
Full Issue, The Press At Cal Poly Humboldt
IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt
No abstract provided.
Narrative, Identity, And Liminality Of Player Development Personnel In Ncaa Power 4 Conferences: Supporting Athlete Identity Development And Navigating Role Evolution In The Nil Implementation Era, Joseph L. Herman Ii
Journal of Issues in Intercollegiate Athletics
Derived from a larger study, this article examines Player Development Personnel (PDPs) in NCAA Power 4 (P4) conferences as they support athlete identity development and navigate role evolution during the NIL implementation era. Although academic advisors and support staff have long contributed to athlete development, limited scholarship has examined how PDPs understand their professional identities, responsibilities, and institutional constraints in NIL-era athletics. Guided by the Narrative, Identity, and Liminality Model (NILM), MNF, and institutional logics, this study situates PDP work within an ecosystem shaped by commercialization, racialized narratives, and organizational expectations (McLean & Syed, 2015; Southall et al., 2008). Semi-structured …
Educating Ncaa Student-Athletes To Mitigate Social Media Risks: Results From An Intervention Pilot Program, Ksenia Power, Nataliya Bredikhina, Bomin Paek
Educating Ncaa Student-Athletes To Mitigate Social Media Risks: Results From An Intervention Pilot Program, Ksenia Power, Nataliya Bredikhina, Bomin Paek
Journal of Issues in Intercollegiate Athletics
With the introduction of the NCAA’s Name, Image, and Likeness (NIL) policy in July 2021, student-athletes have become increasingly reliant on social media for personal branding and monetization. However, prior research suggests that excessive social media use can negatively impact student-athletes’ well-being, highlighting the need for targeted digital literacy education. Addressing these concerns, this study designed and evaluated an online intervention, “Student-Athlete Training for Online Resilience Management” (STORM), aimed at improving student-athletes’ perceived knowledge and confidence in navigating social media-related risks. Using two waves of survey data (N = 117), the study assessed changes in perceived knowledge of social …
Big Fish Or Little Pond? National Evidence On The Relationship Between Transferring And Athletic Performance Within Division I Men's College Basketball, Kendall Cole, Francis A. Pearman Ii, Saurabh Khanna
Big Fish Or Little Pond? National Evidence On The Relationship Between Transferring And Athletic Performance Within Division I Men's College Basketball, Kendall Cole, Francis A. Pearman Ii, Saurabh Khanna
Journal of Issues in Intercollegiate Athletics
Beginning with the introduction of the transfer portal in 2018, the National Collegiate Athletic Association (NCAA) has made several policy changes that have made transferring both easier and more desirable among student athletes, particularly in Division I (DI) revenue-generating sports. Yet, little is known about the relationship between transferring and student athletes’ athletic performance. Using individual- and team-level data on all DI men’s college basketball student athletes from the 2018-19 season through the 2023-24 season, we examine the relationship between transferring and athletic performance, specifically one’s points per game, minutes per game, and number of games started per season. Results …
Online Harassment And Mental Health Among Collegiate Student-Athletes: Findings From An Ncaa Division I Conference Survey, M. Courtney Hughes, Michelle K. Demaray, Emily A. Skiba, Sarah E. Warriner
Online Harassment And Mental Health Among Collegiate Student-Athletes: Findings From An Ncaa Division I Conference Survey, M. Courtney Hughes, Michelle K. Demaray, Emily A. Skiba, Sarah E. Warriner
Journal of Issues in Intercollegiate Athletics
Social media is central to college athletics, yet public visibility can expose collegiate student-athletes to online harassment, a risk the NCAA has recently highlighted by documenting sizable volumes of abusive, discriminatory, and betting-related content directed at athletes and officials. This study surveyed 85 NCAA Division I student-athletes from ten universities across the Mid-American Conference and assessed social-media behaviors, online harassment exposure, depression, and anxiety. Most athletes used social media 1–3 hours/day, 78% enabled name-mention alerts, and platforms commonly used included Instagram (98.8%) and X (65.9%). Online harassment was reported via social posts (9.4%), direct messages (4.7%), and texts (3.5%), with …
“Where’S This Energy When They’Re Killing Us!?”: Black Sport Media, Disruptions Of Linked Fate, And The Plantation Politics Of Protection, Sayvon Jl Foster
“Where’S This Energy When They’Re Killing Us!?”: Black Sport Media, Disruptions Of Linked Fate, And The Plantation Politics Of Protection, Sayvon Jl Foster
Journal of Issues in Intercollegiate Athletics
Following the viral interaction between Nyck Harbor and the Texas State Trooper, Black sport media figures dominated the discourse surrounding the incident. By centering Black sport media figures as sources of discursive authority, this study illuminates the role of (Black) sport media in shaping the understanding and response to experiences of Black college athletes. Using Thompson’s (2022) abductive thematic content analysis, commentary from eight prominent Black sport media voices - Bomani Jones, Stephen A. Smith, Ryan Clark, Cam Newton, Von Miller, Marcellus Wiley, Jason Whitlock, and Etan Thomas - was analyzed. With Dawson's (1994) Linked Fate Theory (LFT) as the …
Understanding Parents Perceptions Concerning Division I Student-Athlete Mental Health, Jonathan M. Casper, Jason Bocarro, Marie Amidon
Understanding Parents Perceptions Concerning Division I Student-Athlete Mental Health, Jonathan M. Casper, Jason Bocarro, Marie Amidon
Journal of Issues in Intercollegiate Athletics
Collegiate student-athletes (SAs) frequently underreport mental health concerns and are less likely to seek professional support compared to their non-athlete peers. Given the substantial emotional and academic support parents provide, this study examined NCAA Division I parents’ perceptions of their student-athletes’ mental health and overall well-being, as well as their awareness and perceptions of available mental health services. An online survey (N = 178) was administered across two Division I universities. Parents reported considerable concern regarding mental exhaustion, anxiety, academic pressures, and future planning. They also identified sport-specific stressors, including relationships with coaches, playing time, team dynamics, and injuries. Although …
2nd National Research Day Lebanese Medical Schools
2nd National Research Day Lebanese Medical Schools
MEAMS Middle East Annals of Medical Sciences - Saint Joseph University of Beirut
No abstract provided.
The Association Between Generative Artificial Intelligence Use And Students' Critical Thinking Performance In Uae Higher Education, Halima Omar
Thesis/ Dissertation Defenses
The rapid integration of Artificial Intelligence (AI) into higher education has reshaped how students engage with learning, raising critical questions about its influence on higher-order cognitive development. This topic is particularly prominent in the United Arab Emirates (UAE), where national priorities emphasize technological dominance and the development of a knowledge-based economy that demands the cultivation of graduates’ critical thinking competencies. Despite widespread AI adoption, empirical evidence linking patterns of AI use to critical thinking performance remains scarce. This dissertation fulfils this gap by examining the relationship between AI use and critical thinking among UAE higher education students, with particular attention …
Neuromuscular Responses During Vigorous Intensity Heart Rate-Clamp Cycling Exercise, Clara J. Mitchinson, Pasquale J. Succi, Brian Benitez, Djadmann Gustave, Minyoung Kwak, Erik Snell, Haley C. Bergstrom
Neuromuscular Responses During Vigorous Intensity Heart Rate-Clamp Cycling Exercise, Clara J. Mitchinson, Pasquale J. Succi, Brian Benitez, Djadmann Gustave, Minyoung Kwak, Erik Snell, Haley C. Bergstrom
Journal for Sports Neuroscience
Introduction: Electromyography (EMG) and mechanomyography (MMG) provide non-invasive assessments of neuromuscular function and fatigue during dynamic exercise. This study examined neuromuscular fatigue and cycling performance through changes in power output (PO), total work (TW), EMG and MMG, amplitude (AMP) and mean power frequency (MPF) during three, heart rate (HR)-Clamp trials in the vigorous range (77-95% HRmax). Methods: Ten men (mean±SD, 25.9±5.0yr, 74.9±15.0kg, HRmax=178±12b×min-1) performed a cycle ergometer graded exercise test, followed by three separate HR-Clamp trials at 77%HRmax (HRL, time to exhaustion [TLim]=58.5±4.6 min, range=45.3-60.0min), 86%HRmax (HRM …
A Professional Development Course On Data-Driven Dynamical Systems At A Primarily Undergraduate Institution: Part A - Scientific Content, Alessandro M. Selvitella, Jeffrey R. Anderson
A Professional Development Course On Data-Driven Dynamical Systems At A Primarily Undergraduate Institution: Part A - Scientific Content, Alessandro M. Selvitella, Jeffrey R. Anderson
CODEE Journal
In the age of data-driven decision making, ordinary differential equations (ODEs) remain a powerful and interpretable framework for modeling dynamic processes, especially when integrated with modern tools from statistical learning and data-driven dynamical systems. Yet, general undergraduate and graduate curricula do not typically address key opportunities in data-driven dynamical systems.
This first paper in a series focuses on the mathematical and methodological core of a professional development course first developed in the academic year 2025-2026 at a Primarily Undergraduate Institution, Purdue University Fort Wayne. The curriculum developed in this course emphasized how regression, regularization, and sparse identification can be used …
Impact Of Insurance On In-Hospital Mortality And Other Outcomes Among Patients With Acs And Cardiogenic Shock: A Nationwide Analysis From 2022., Renzo Aller, Aura Calderon
Impact Of Insurance On In-Hospital Mortality And Other Outcomes Among Patients With Acs And Cardiogenic Shock: A Nationwide Analysis From 2022., Renzo Aller, Aura Calderon
Research Symposium
Introduction: Insurance coverage may significantly affect access to timely and advanced cardiovascular therapeutic interventions within the United States. Among individuals experiencing acute myocardial infarction (AMI) accompanied by cardiogenic shock (CS), variations based on the primary payer may play a role in subsequent in-hospital outcomes. We conducted a retrospective analysis to determine whether insurance status correlates with in-hospital mortality and other outcomes among patients with AMI and CS, utilizing the NIS database.
Methods: ACS patients in the 2022 NIS were categorized as STEMI or NSTE-ACS using appropriate ICD‐10 codes. Patients with both types of ACS and cardiogenic shock were included in …
The Triple Threat: Hiv, Nonadherence, And Substance Use Driving Premature Coronary Events, Jose J. Loayza Pintado, Taiwo Ajani, Angelica Lopez Jesus, Aura Calderon, Jose Pena
The Triple Threat: Hiv, Nonadherence, And Substance Use Driving Premature Coronary Events, Jose J. Loayza Pintado, Taiwo Ajani, Angelica Lopez Jesus, Aura Calderon, Jose Pena
Research Symposium
Background: People living with HIV (PLWH) experience nearly double the risk of premature atherosclerotic cardiovascular disease and often present with acute coronary syndromes at younger ages [1]. Chronic inflammation, immune activation, and drug–drug interactions between antiretrovirals and antiplatelet agents further contribute to accelerated atherosclerosis and poor outcomes after percutaneous coronary intervention (PCI) [2,3]. Importantly, in-stent restenosis (ISR) remains disproportionately frequent in PLWH despite modern drug-eluting stents, with medication nonadherence compounding risk [4]. We present a young woman with HIV and recurrent myocardial infarction due to rapid ISR, underscoring the impact of inflammation, adherence, and pharmacologic interactions on secondary prevention.
Case …
Survival Outcomes And Tumor Site Distribution By Molecular Subtype In Breast Cancer Patients Under 40, Muhammad Noorani, Shubhank Goyal, Sierra Viduarri, Aura Calderon, Christine Pham, Shweta Singh, Mutaaz Ahmed, Anupam Dhasmana, Swati Dhasmana, Murali Yallapu, Shubash Chauhan, Diane Nguyen, Sidketa Fofana, Sheema Khan
Survival Outcomes And Tumor Site Distribution By Molecular Subtype In Breast Cancer Patients Under 40, Muhammad Noorani, Shubhank Goyal, Sierra Viduarri, Aura Calderon, Christine Pham, Shweta Singh, Mutaaz Ahmed, Anupam Dhasmana, Swati Dhasmana, Murali Yallapu, Shubash Chauhan, Diane Nguyen, Sidketa Fofana, Sheema Khan
Research Symposium
Background: Screening guidelines for breast cancer typically begin at age 40, leaving younger women at risk for delayed detection. The survival outcomes and tumor site patterns by subtype in this younger population remain underexplored. Our analysis leverages comprehensive national data to fill this critical knowledge gap, offering one of the most detailed evaluations to date of molecular subtype distribution, prognostic disparities, and anatomical presentation in women under 40.
Methods: Using the SEER 18 registry, we identified 5,026 female patients diagnosed under age 40 with invasive breast cancer in 2018. This year was selected for the most recent data available on …
Severe Cold Agglutinin Hemolytic Anemia Secondary To Mycoplasma Pneumoniae And Epstein-Barr Virus Co-Infection In An Elderly Patient, Aura Mc Calderon, Jose Loayza, Luis Salcedo, Ivan Mogollon, Asmik Asatrian
Severe Cold Agglutinin Hemolytic Anemia Secondary To Mycoplasma Pneumoniae And Epstein-Barr Virus Co-Infection In An Elderly Patient, Aura Mc Calderon, Jose Loayza, Luis Salcedo, Ivan Mogollon, Asmik Asatrian
Research Symposium
Introduction: Cold autoimmune hemolytic anemia (AIHA) is an uncommon, complement-mediated hemolysis typically driven by IgM autoantibodies; secondary forms are often infection-related. Severe, transfusion-refractory presentations are rare in older adults. We present an elderly patient with Mycoplasma pneumoniae and Epstein–Barr virus co-infection complicated by life-threatening cold agglutinin hemolysis.
Case report: Upon admission, a 79-year-old male patient presented with a one-week history of fatigue, pyrexia, nasal congestion, and dyspnea; examination findings revealed pallor, bibasilar crackles, and mild splenomegaly. Laboratory investigations indicated the presence of severe hemolytic anemia accompanied by compensatory reticulocytosis and thrombocytosis (hemoglobin 5.5 g/dL, hematocrit 17.2%, MCV 100 fL, reticulocytes …
Iptacopan-Responsive Pnh With Pancytopenia: Hematologic Normalization And Dose Adjustment For Transaminitis, Aura Mc Calderon, Jose Loayza, Francisco Arias, Catherine Matos, Bharat Peddinani, Diane Nguyen
Iptacopan-Responsive Pnh With Pancytopenia: Hematologic Normalization And Dose Adjustment For Transaminitis, Aura Mc Calderon, Jose Loayza, Francisco Arias, Catherine Matos, Bharat Peddinani, Diane Nguyen
Research Symposium
Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem-cell disorder driven by loss of GPI-anchored complement regulators (CD55, CD59), leading to complement-mediated intravascular hemolysis, cytopenias, and thrombosis. We report a new PNH diagnosis in a young woman with severe pancytopenia who achieved hematologic improvement on oral iptacopan, requiring dose adjustments for mild liver enzyme elevation.
Case Report: On February 27, 2025, a 38-year-old female patient exhibited symptoms of progressive fatigue, dyspnea, and jaundice. Initial laboratory assessments indicated the presence of severe hemolytic anemia accompanied by pancytopenia, hemoglobin level recorded at 4.7 g/dL, white blood cell count at 1.6×10³/µL (absolute …
Expression And Functional Significance Of The G Protein–Coupled Estrogen Receptor (Gper) In Breast Cancer Subtypes, Sierra E. Vidaurri, Shweta Singh, Valerie E. Ledezma, Rajasekhar Baru, Emma Garza, Francisco Flores, Muhammad Noorani, Shubhank Goyal, Aura Calderon, Alexander Lim, Anupam Dhasmana, Swati Dhasmana, Murali Yallapu, Subhash Chauhan, Diane Nguyen, Sheema Khan
Expression And Functional Significance Of The G Protein–Coupled Estrogen Receptor (Gper) In Breast Cancer Subtypes, Sierra E. Vidaurri, Shweta Singh, Valerie E. Ledezma, Rajasekhar Baru, Emma Garza, Francisco Flores, Muhammad Noorani, Shubhank Goyal, Aura Calderon, Alexander Lim, Anupam Dhasmana, Swati Dhasmana, Murali Yallapu, Subhash Chauhan, Diane Nguyen, Sheema Khan
Research Symposium
Background: The G protein–coupled estrogen receptor (GPER) mediates rapid non-genomic estrogen signaling and has been implicated in breast cancer progression and aggressiveness. However, its expression patterns across molecular subtypes and its direct functional contribution to tumor behavior remain incompletely defined. The objective of this study was to comprehensively characterize GPER expression in breast cancer tissues and to functionally validate its role in regulating tumor cell proliferation and migration using genetic modulation approaches.
Methods: GPER expression was evaluated in breast cancer cell lines and patient tumor tissues using immunohistochemistry (IHC), Western blotting, and RT-PCR. Tumors were classified into Luminal A, Luminal …