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Prevalence And Risk Factors Of Surgical Site Infections In Hospitals Across Al Madinah Al Munawwarah, Saudi Arabia: A Retrospective Cohort Study, Atheer M. Aljohani, Danah O. Sandaqji, Rana A. Alahmadi, Raha Z. Ishqi, Manal A. Alanazi, Shouq N. Aloufi, Husain I. Sandugji

Saudi Medical Journal

Objectives: To determine the prevalence of surgical site infection (SSI) and identify associated risk factors in hospitals in Al Madinah Al Munawwarah, Saudi Arabia.

Methods: We conducted a retrospective cohort study of 363 adult surgical patients from major hospitals in Madinah between 2023 and 2024. We analyzed medical records using descriptive statistics, bivariate analysis, and multivariable logistic regression.

Results: The overall SSI rate was 5.2% (95% confidence interval [CI]: 3.3–7.9%). Infection types comprised superficial incisional (57.9%), deep incisional (36.8%), and organ/space infections (5.3%). Significant risk factors included younger age (adjusted odds ratio [aOR] = 0.94 per year, p = 0.014), …

A Predictive Model For Cytomegalovirus Infection Using Routine Hematological And Biochemical Parameters: A Pilot Study, Ahmad A. Shaikh, Mofareh H. Alabdaly, Nabil A. Ageeli, Sultan Z. Alasmari, Adel M. Abo Mansour, Mohammed H. Makkawi

Saudi Medical Journal

Objective: To examine whether hematological and biochemical parameters assist in diagnosing cytomegalovirus (CMV) infections and differentiating between CMV-G and CMV-M. Cytomegalovirus causes distinct hematological changes that can serve as markers for diagnosis.

Methods: A retrospective analysis was conducted on 54 patients infected with CMV (25 CMV-G and 29 CMV-M) and 82 healthy controls. Age, gender, and routine hematological and biochemical parameters were evaluated. Receiver operating characteristics (ROC) analysis and logistic regression were used for data analysis.

Results: In comparison to controls, laboratory findings of patients with CMV-G revealed characteristic decreases in red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), and …

Safety And Efficacy Of Adalimumab Biosimilar In Psoriasis And Hidradenitis Suppurativa: A Clinical Experience, Raneem H. Najjar, Sarah O. Alrashid, Rnda F. Almahfouz, Hadeel T. Alzahrani, Majed Y. Aleissa, Alanoud R. Hakami

Saudi Medical Journal

Objectives: To evaluate the clinical experience, safety, and effectiveness of adalimumab biosimilars in patients with psoriasis and hidradenitis suppurativa.

Methods: We conducted a retrospective, single-center observational study between March and September 2024 using electronic medical records from King Abdulaziz Medical City and King Abdullah Specialized Children's Hospital, Riyadh, Saudi Arabia. Pediatric and adult patients with psoriasis or hidradenitis suppurativa who switched to adalimumab biosimilars between 2016 and 2022 were included. Variables included demographics, disease characteristics, prior therapies, biosimilar use, and adverse events.

Results: A total of 57 (93% adults; 50.9% female) patients were included. Obesity was present in 35.1%, and …

Immunoinformatic Based Development Of A Multi-Epitope Precision Vaccine Targeting Glycoprotein And Rdrp Of Oropouche Virus: An Innovative Approach To Counter Emerging Public Health Threats, Mohammed Alissa, Muhammad Suleman

Saudi Medical Journal

Objectives: To design high immunogenic vaccine against the Oropouche virus (OROV). The OROV is a neglected arbovirus endemic to Central and South America, causes oropouche fever, which can progress to severe complications such as meningitis and hemorrhagic symptoms.

Methods: We utilized immunoinformatic and molecular dynamic simulation approaches to design highly immunogenic vaccines against OROV. This observational study, carried out between January and August 2024 in Saudi Arabia. As it involves an in-silico method, ethical consent was not required.

Results: Docking analysis confirmed the stable interaction of the designed vaccines with human toll-like receptors (TLR)-3, producing binding scores of –300.78, –306.19, …

Comparison Of The Effects Of Incubator And Radiant Environments On Physiological Criteria And Pain-Stress Levels During Heel Lance In Neonates In The Neonatal Intensive Care Unit: A Randomized Controlled Trial, Sezin Gürsu, Birsen Karaca Saydam, Oğuzhan Kalkanlı

Saudi Medical Journal

Objectives: To compare the effects of incubator and radiant heat on physiological criteria and pain-stress levels during heel prick procedures in newborns in the neonatal intensive care unit (NICU).

Methods: This randomized controlled quasi-experimental study was conducted between June and December 2023 with newborns diagnosed with IHB hospitalized at a NICU in Turkey. Prior to the heel prick procedure, 72 newborns (gestational age: 37–41 weeks) were randomly and equally assigned to either a radiant heater or an incubator setting. Physiological parameters (temperature, SpO₂, heart rate [HR]) and pain-stress scores of the newborns were measured and compared in both …

Etiology, Management, And Outcomes Of Hospitalized Heart Failure Patients: A Single-Center Study, Adil I. Jumani, Ghada A. Rashwan, Hadiza O. Ibrahim, Safaa M. Almohdar, Khaled M. Alfakih

Saudi Medical Journal

Objectives: To describe the clinical characteristics, etiologies, management patterns, and outcomes of hospitalized heart failure patients in a tertiary care military hospital in United Arab Emirates (UAE), and to benchmark guideline directed medical therapy (GDMT) uptake and care models against regional and international registries.

Methods: We retrospectively reviewed all consecutive patients admitted with a primary diagnosis of heart failure between January and December 2024, at Zayed Military Hospital, UAE. Clinical data were extracted from electronic medical records. The GDMT adherence was assessed according to the 2022 American Heart Association (AHA)/ American College of Cardiology (ACC) and 2023 European Society of …

Identification Of Risk Factors For Renal Insufficiency In Primary Membranous Nephropathy, Lin Qi, Bolong Fang, Xiao Fang, Yamin Yu, Yunqiang Wang

Saudi Medical Journal

Objectives: To identify possible evidence linking certain characteristics associated with primary membranous nephropathy (PMN) to renal failure progression in patients diagnosed with PMN and to establish probable evidence of an association between PMN and other risk factors leading to end-stage renal failure.

Methods: A historical investigation was carried out including 436 subjects with PMN, with or without renal insufficiency, who were treated at the No. 82 Division Defense Medical Center of the People's Liberation Army and Liaocheng People's Medical Center during January 2020 and December 2023. Binary logistic regression study was applied to determine possible hazard elements. Binary logistic regression …

Evaluation Of Raqeem Health Information System In Primary Healthcare Centers In Makkah, Saudi Arabia, Using The Delone And Mclean Information System Success Model, Ali M. Alzahrani, Holly C. Felix

Saudi Medical Journal

Objectives: To evaluate the implementation of Raqeem, a new Electronic Health Information Systems (EHIS) implemented at primary healthcare centers (PHCs) in Makkah. Implementing EHIS requires huge investments, making evaluation of systems success important.

Methods: In this cross-sectional survey design study, a developed questionnaire guided by DeLone and McLean Information System success model (D&M model) was used to collect data from PHCs' providers. Descriptive and structural equation modeling (SEM) techniques were performed to describe and examine the association between the model's constructs and assess Raqeem success.

Results: A total of 490 providers submitted completed records and were included in this study. …

Molecular Mechanisms Of Diffuse Large B-Cell Lymphoma And The Complexities Of Tumor Development, Wael I. Alzahrani

Saudi Medical Journal

Diffuse large B-cell lymphoma (DLBCL), the most prevalent aggressive non-Hodgkin lymphoma, exhibits substantial molecular heterogeneity and arises from germinal center or post-germinal center B cells through recurrent genetic and epigenetic dysregulation of critical signaling pathways. Aberrations involving BCL6, MYC, MYD88, and components of B cell receptor and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κ B) signaling play central roles in lymphomagenesis, treatment resistance, and clinical outcomes. Gene expression profiling has defined major molecular subgroups in DLBCL, including germinal center B cell–like and activated B cell–like tumors, that show distinct pathogenesis and prognosis. High-risk entities, such as double- and …

Integrating Traditional And Complementary Medicine Into Saudi Primary Care: A Literature Review In Light Of The Who 2025–2034 Strategy, Abeer Al Shahrani

Saudi Medical Journal

Complementary and alternative medicine (CAM) is widely practiced in Saudi Arabia, particularly for health promotion and chronic diseases management. Despite cultural acceptance and high utilization, CAM remains largely unintegrated within the formal healthcare system, particularly in primary care settings. The newly adopted World Health Organization (WHO) Traditional, complementary, and integrative medicine (TCIM) Strategy 2025–2034 offers a global framework for evidence-based, culturally appropriate integration of TCIM into national systems. This review evaluates the status of CAM in Saudi Arabia in light of strategic objectives outlined in the WHO Strategy: building the evidence base, ensuring quality and safety, integrating into health systems, …

Interleukin-6 Inhibition For Patients With Acute Myocardial Infarction: A Systematic Review And Meta-Analysis, Mohammed Y. Alasmary, Mohammed J. Almalki, Faisal H. Almalki, Waleed D. Khubzan, Mohammed H. Rajab, Mohammed S. Almalki, Hussam A. Almalki, Omar M. Alsuwat, Hussam M. Alghannami

Saudi Medical Journal

Objective: To explore the outcomes associated with interleukin-6 (IL-6) pathway blockade, using tocilizumab, in patients with ST-elevation myocardial infarction (STEMI) and non (NSTEMI). Acute myocardial infarction (AMI) denotes myocardial necrosis due to ischemia and presents in distinct electrocardiographic phenotypes. Inflammation driven by IL-6 contributes to ischemia-reperfusion injury, with tocilizumab showing promise in reducing myocardial damage and improving outcomes.

Methods: This work followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Framework and was registered in international prospective register of systematic reviews (PROSPERO). Relevant studies were identified through structured searches of PubMed, MEDLINE, the Cochrane Library, and Google Scholar up …

Effect Of Anesthetic Agents On Middle Ear Pressure: Systematic Review And Meta-Analysis, Nasser Almujaiwel, Reem Alkublan, Latifah Almakoshi

Saudi Medical Journal

Objective: To assess and compare the effects of these agents on middle ear pressure (MEP). Anesthetic agents can significantly alter MEP, which is a critical factor in middle ear surgeries that require stability to prevent complications. Different anesthetics, including inhalational and intravenous agents, have varying effects on MEP.

Methods: A systematic search was conducted across PubMed, Embase, the Cochrane Library, and Scopus, following preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. Studies that evaluated MEP changes before and after anesthesia using tympanometry were included. Relevant data, such as anesthetic type, patient demographics, MEP measurements, and reported complications, were …

The Impact Of Exercise Intervention On Pulmonary And Physical Function In Patients With Cystic Fibrosis: A Comprehensive Systematic Review, Abdullilah Alghamdi, Muroj Al-Attas, Abrar Radhi, Amnah Alfaqih, Bashair Aljabri, Rawan Alharbi, Sumayyah Alsubaie, Raneem Aljawaied, Sarah Alenazi, Ahlam Mazi, Ebtehal Qulisy

Saudi Medical Journal

Objective: To evaluate the effect of various exercise interventions on lung function, specifically forced expiratory volume in 1 second (FEV₁), maximum inspiratory pressure (MIP), and maximum expiratory pressure (MEP), as well as on cardiorespiratory fitness (peak oxygen uptake [VO₂peak]), and muscle strength (handgrip strength). The review also considers factors such as patient adherence, follow-up duration, and statistical significance to inform clinical practice.

Methods: This systematic review followed preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines and was prospectively registered in international prospective register of systematic reviews. PubMed, Google Scholar, OVID, and Web of Science …

Diagnostic Timeliness And Pre-Implant Nonverbal Development In Thai Children With Severe-To-Profound Sensorineural Hearing Loss: A 2017–2024 Retrospective Review, Wanpen Ritthita, Sureelak Sutchritpongsa, Pat Rojmahamongol, Prakasit Wannapaschaiyong

Journal of Child Science

Background: Congenital severe-to-profound sensorineural hearing loss (SNHL) may compromise early development, and timely cochlear implantation (CI) is essential; however, data from low- and middle-income countries, where universal newborn hearing screening is limited and referral is delayed, remain scarce. This study describes diagnostic timeliness and CI referral in Thai children with congenital severe-to-profound SNHL, and reports age-stratified pre-implant nonverbal developmental profiles as secondary contextual descriptive data. Methods: A retrospective chart review was conducted at Siriraj Hospital, Bangkok, Thailand. Children with congenital severe-to-profound SNHL who underwent pre-CI developmental or non-verbal cognitive assessments between January 2017 and December 2024 were enrolled. Data on …

Central Congenital Hypothyroidism In A Preterm Infant Born To A Mother With Graves’ Disease: A Case Report, Aliyyah M. Khuzaini, Hani A. Zulkeflee, Nur A. Zulkefli, Ain Najmy A. Zairy, Siti Farah A. Roslan

Journal of Child Science

Background: Central congenital hypothyroidism (CCH) is an uncommon but potentially underdiagnosed condition, particularly in infants born to mothers with autoimmune thyroid disease. Case Presentation: We report a case of central congenital hypothyroidism in a preterm baby born to a mother with hyperthyroidism, diagnosed three years prior to conception. She developed thyrotoxicosis at 30 weeks of pregnancy requiring Lugol’s iodine, carbimazole and propranolol. She subsequently developed pre-eclampsia and went into preterm Labour at 31 weeks of gestation. Her Thyroid Stimulating Hormone (TSH) receptor antibody levels were high, while anti-peroxidase and anti-thyroglobulin antibodies were negative. The cord TSH level at birth was …

Enhancing Visual-Spatial And Social Communication Skills In Children With Autism Through The Autistic Ready To Play Program, Adidsuda Fuengfoo, Nipontorn Saengthongsri, Pentrakarn Saengthongsri, Netsai Thongchamrat, Nutchanat Promiam, Montika Rattanaruengsin, Lutlawan Lamomsai, Pongpun Jinpla

Journal of Child Science

Background: Autism Spectrum Disorder (ASD) is characterized by deficits in social communication and repetitive behavioral patterns. Leveraging the strong visual learning abilities of children with ASD, the Autistic Ready to Play (ARP) program was developed to improve visual-spatial skills, spatial reasoning, and social communication through structured, play-based activities. Objective: This study aims to identify the impacts of the ARP program on language, social communication, sensory perception, physical health, and behavioral dimensions in autistic children. Methods: This study included 99 children with ASD, aged 4–10 years, who were randomly assigned to three groups. Group 1 received standard developmental care, while Groups …

Pharmacovigilance For Health Management: A National Profile Of Methylphenidate Adverse Events In Thailand Using National Databases, Suwapat Sukthas, Pornpan Soontorntham, Surasak Saokaew

Journal of Health Research

Background: Methylphenidate, a Schedule II psychostimulant, is indicated for ADHD in children ≥6 years when other measures fail, with unclear adult indications beyond narcolepsy. Global use increases necessitate robust pharmacovigilance, especially in low/middle-income countries like Thailand where safety data is sparse. This study characterized methylphenidate-associated adverse events (AEs) in Thailand, analyzing product types and patient factors.

Methods: Spontaneous Thai Vigibase™ reports (2005-2024) were analyzed alongside national distribution data. AEs were MedDRA-coded and stratified by age, sex, indication, formulation (original/generic; immediate/extended-release), allergy history, and comorbidities. Reporting Odds Ratios (RORs) identified safety signals. Serious AEs followed WHO criteria.

Results: Among 424 patients …

Cure Sickle Cell Initiative Recommendations On Common Data Elements For Sickle Cell Disease Gene Therapy Trials, Sophie Lanzkron, Victoria H. Coleman-Cowger, Alexis A. Thompson, C. Patrick Carroll, Traci Clemons, Michael Debaun, Julie Kanter, Punam Malik, Deepa Manwani, Francis John Pierciey, Mark C. Walters, Sherita Alai

Cardeza Foundation for Hematologic Research

The Cure Sickle Cell Initiative (CureSCi), created by the National Heart, Lung, and Blood Institute, has developed data standards to increase interoperability and meta-analysis of studies specifically investigating gene therapy for sickle cell disease (SCD). The aims of the CureSCi Common Data Elements (CDE) initiative are to facilitate the development of safe, effective, and accessible gene therapies. Five working groups (WGs) comprising people living with SCD, stakeholders, clinicians, and researchers reviewed current definitions used for SCD clinical studies, including those from the American Society of Hematology, US Food and Drug Administration, PhenX catalog of consensus measures for phenotypes and exposures, …

Pregnancy In Type I Interferon Receptor (Ifnar2) Knockout Sheep Challenges The Accepted Paradigm For Pregnancy Recognition In Ruminants, Christopher J. Davies, Evan K. Peterson, Aaron J. Thomas, Andrea L. Giles, Young-Min Lee, Irina A. Polejaeva, Heloisa M. Rutigliano

Veterinary Clinical and Life Science Faculty Publications

The effects of type I interferons, including interferon tau (IFNT), previously thought to be the signal for pregnancy recognition in ruminants, are mediated by the type I interferon receptor (IFNAR), a heterodimer comprised of IFNAR1 and IFNAR2. The genes encoding IFNAR were disrupted in fetal fibroblast cells using CRISPR/Cas9 and lambs were produced by somatic cell nuclear transfer (SCNT). Subsequently, a herd of IFNAR2^+/− sheep was developed and used to produce IFNAR2^−/− lambs. Functional knockout of IFNAR was confirmed by failure of fibroblast cell lines from IFNAR2^−/− sheep to respond to interferon alpha or IFNT in a …

Disability Rates Among South Asian Immigrants In The U.S. Vary By Country Of Origin, Sobia Mushtaq, Marc A. Garcia

Population Health Research Brief Series

South Asian immigrants are often grouped together in U.S. health data, masking significant differences in health outcomes across subgroups. This brief uses data from the American Community Survey (ACS) 5-Year Public Use Microdata Sample (N = 6,643,738; 2020–2024) to describe disability rates among foreign-born adults from India, Pakistan, and Bangladesh residing in the U.S. The authors find that while South Asian immigrants as a group have lower disability rates than U.S.-born adults, this average is driven largely by Indian immigrants, who make up about 79% of South Asians in the U.S. Among adults aged 65 and older, Bangladeshi immigrants have …

Craig Kimmel V. Massachusetts Bay Insurance Co

2026 Decisions

USDC for the District of New Jersey

Determinants Of Public-To-Private Transitions: Evidence From Firm-Level Selection Patterns, Joshua S. Wolfson

Economics Undergraduate Senior Theses

This paper considers which publicly traded firms are most likely to exit public markets through acquisition, and how those patterns differ between financial sponsors and strategic acquirers. Using a panel of 3,320 U.S. public firms from 2000 to 2024, I estimate discrete-time hazard models and find that lower valuation multiples, higher leverage, and stronger free cash flow predict going private. These characteristics vary for financial sponsors and strategic acquirers who select on different criteria. Strategic selection is driven mainly by leverage and valuation while private equity is also driven by free cash flow. These criteria are not stable over time, …

Distance And Trade Elasticity: The Red Sea Crisis As A Natural Experiment, Felix C. Feldman

Economics Undergraduate Senior Theses

This paper exploits the 2023 Houthi attacks on shipping through the Bab el-Mandeb Strait at the entrance to the Red Sea and the subsequent mass rerouting around the Cape of Good Hope to estimate modern-day elasticities with respect to effective trade cost. This event is unique among chokepoint disruptions as it did not lead to a complete blockage. Instead, many ships voluntarily rerouted away the area, but not all. This paper uses a structural approach to infer unobservable costs incurred by inframarginal Red Sea shippers. This paper combines a reduced-form gravity specification with a discrete route-choice model where ships select …

Exploring The Impact Of Leadership Development On The Sense Of Belonging Among Collegiate Black Men, Todd Lamont Jenkins

Theses and Dissertations

This qualitative case study used Strayhorn’s Sense of Belonging Model (2018) to examine how collegiate Black men experienced affirmation, connection, and mattering through participation in Leaders of the Free World (LFW), a culturally grounded program integrating mentoring, leadership development, and short term study abroad. Through semi structured interviews, a focus group, and document analysis, five themes emerged: (1) Global Exposure and Cultural Heritage, (2) Identity Development, (3) Academic Realignment, (4) Mentoring and Relationship Growth, and (5) Leadership Capacity Building. Findings show that LFW fostered the core belonging conditions Strayhorn (2018) identifies: psychological safety, meaningful relationships, validation, and institutional navigation support. …

U.S. Black Men’S Perceptions Of The Similarities And Interplay Among Mind-Body Practices, Spirituality, And Religion: A Qualitative Study, Khanh Pham

Theses and Dissertations

This qualitative study explored U.S. Black men’s perceptions of relations among mind-body practices (MBPs), spirituality, and religion to understand how these factors might influence Black men’s health. Reflexive thematic analysis was used to analyze data from individual semi-structured interviews with 18 Black male MBP instructors. Five themes were generated. The themes were (1) spirit(uality) is the foundation for Black men’s experience of life seen and unseen, (2) MBPs and religion are rooted in spirituality, (3) MBPs, religion, and Black culture share common characteristics, (4) MBPs and religion facilitate holistic wellbeing, and (5) confusion and negative perceptions about MBPs, spirituality, and …

Context-Sensitive Control-Flow Analysis For Non-Standard Language Semantics, Tim Whiting

Theses and Dissertations

Control-Flow Analysis (CFA) is a static technique for understanding the execution of higher-order programs without running the code. CFA aids in identifying bugs, assisting program comprehension, and exposing optimization opportunities. Constructing a CFA typically begins with an idealized evaluator--such as an abstract machine or interpreter--and proceeds by approximating components of evaluation to ensure that: (a) the analysis is sound (representing all possible behaviors), and (b) the analysis is guaranteed to terminate (finitely representable). These constraints necessitate a loss of precision, providing an approximation of the values that flow to program locations rather than exact execution traces. This imprecision causes the …

Testing The Moderating Effect Of Self-Compassion On The Relationship Between Perfectionism-Related Discrepancy And Perceived Social Support From Family, Marinne Hammond

Theses and Dissertations

Perfectionism involves an insistence on outstanding performance on tasks to an extreme level. More specifically, perfectionism-related discrepancy is when one subjectively sees a gap between their performance and their expectations for how they should perform. Perfectionism may be linked to mental health issues, such as anxiety, depression, eating disorders, and social disconnection. The perfectionism social disconnection model asserts that perfectionism can also lead to social withdrawal. Self-compassion involves the acceptance of imperfection; it has been associated with higher perceived social support and has also been shown to attenuate the relationship between perfectionism and psychological distress. This study aimed to further …

A Qualitative Study Of People With Aphasia And Their Experiences With The Bible, Marin Li

Theses and Dissertations

This phenomenological study explores the lived experiences of 4 individuals with aphasia (1 female, 3 male; 3 Catholic, 1 Lutheran) regarding their relationship with and engagement with the Bible. Participants completed three remote sessions via Zoom. In Session 1, participants completed the Test of Nonverbal Intelligence, Fourth Edition, (TONI-4), and the remote Quick Aphasia Battery (QAB). In Session 2, participants engaged in a semi-structured interview led by the researcher. In Session 3, the researchers presented preliminary analysis to receive feedback from participants. Student researchers coded interview transcriptions to develop a structured codebook. Five primary themes describe the participants' experiences with …

Automated Detection Of Bacterial Flagellar Motors, Eben J. Lonsdale

Undergraduate Honors Theses

With advances in cryogenic electron tomography, the ability to study bacterial structures in their cellular context has improved. However, 3D images of bacteria, called tomograms, have a low signal-to-noise ratio. This makes annotating structures of interest difficult, as traditional computer vision models struggle with tomograms and manual annotation is time consuming. We build on the results of the BYU Kaggle competition to create an ensemble model capable of automatically annotating flagellar models with nearly around 85% accuracy.

Positive Partner Support And Veteran Well-Being: How Capitalization Support Strengthens Military Veterans And Partnerships, Maryann Dona Samson

Dissertations and Theses

Among military veterans, the transition to civilian life is often marked by elevated distress and burnout, low job satisfaction, and a lack of perceived psychological safety. Social support, especially from intimate partners, can serve as a critical protective factor. While most support literature focuses on stress-buffering in adverse contexts, positive social support, such as responsiveness to shared positive experiences (i.e., capitalization support), is a powerful though understudied process. This dissertation investigates the role of partner capitalization support, which is the responsiveness shown by a romantic partner when one shares good news, as a source of stress reduction, resilience, and relational …