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Adjunctive Intravenous Argatroban Or Eptifibatide For Ischemic Stroke, Opeolu Adeoye, Peter Panagos, Stephanie Pizzella, Et Al.

2020-Current year OA Pubs

BACKGROUND: Intravenous thrombolysis is a standard treatment of acute ischemic stroke. The efficacy and safety of combining intravenous thrombolysis with argatroban (an anticoagulant agent) or eptifibatide (an antiplatelet agent) are unclear.

METHODS: We conducted a phase 3, three-group, adaptive, single-blind, randomized, controlled clinical trial at 57 sites in the United States. Patients with acute ischemic stroke who had received intravenous thrombolysis within 3 hours after symptom onset were assigned to receive intravenous argatroban, eptifibatide, or placebo within 75 minutes after the initiation of thrombolysis. The primary efficacy outcome, the utility-weighted 90-day modified Rankin scale score (range, 0 to 10, with …

Efficacy Of Parp Inhibitor Therapy After Targeted Braf/Mek Failure In Advanced Melanoma, Jordan Phillipps, George Nassief, Renee Morecroft, Tolulope Adeyelu, Andrew Elliott, Farah Abdulla, Ari Vanderwalde, Soo Park, Omar Butt, Alice Zhou, George Ansstas

2020-Current year OA Pubs

Modern advancements in targeted therapy and immunotherapy have significantly improved survival outcomes for advanced melanoma; however, there remains a need for novel approaches to overcome disease progression and treatment resistance. In recent years, PARPi therapy has shown great promise both as a single regimen and in combination with other therapeutics in melanoma. Here, we describe three unique cases of advanced BRAF V600 mutated melanoma that progressed on targeted BRAF/MEK agents that subsequently exhibited partial to near-complete responses to combinatory PARPi and BRAF/MEK inhibitors. This highlights both a potential synergy underlying this combinatory approach and its efficacy as a treatment option …

Regional Desynchronization Of Microglial Activity Is Associated With Cognitive Decline In Alzheimer's Disease, Artem Zatcepin, Samira Parhizkar, Et Al.

2020-Current year OA Pubs

BACKGROUND: Microglial activation is one hallmark of Alzheimer disease (AD) neuropathology but the impact of the regional interplay of microglia cells in the brain is poorly understood. We hypothesized that microglial activation is regionally synchronized in the healthy brain but experiences regional desynchronization with ongoing neurodegenerative disease. We addressed the existence of a microglia connectome and investigated microglial desynchronization as an AD biomarker.

METHODS: To validate the concept, we performed microglia depletion in mice to test whether interregional correlation coefficients (ICCs) of 18 kDa translocator protein (TSPO)-PET change when microglia are cleared. Next, we evaluated the influence of dysfunctional microglia …

[Discussions] Vol. 15 Iss. 2

Discussions

No abstract provided.

Societal Evolution: Descent Of Man, Chapter V And The Myth Of Progress, Jakob Hanschu

Discussions

No abstract provided.

Faculty Spotlight: Dr. Patricia Princehouse, Christopher Carr

Discussions

No abstract provided.

[Discussions] Vol. 15 Iss. 1

Discussions

No abstract provided.

A Comparative Analysis Of Media Responses To 1918-1919 Influenza Pandemic In Cleveland Oh, And St.Louis, Mo, Tarun Jella

Discussions

No abstract provided.

The International Legal Personality Of Non-State Armed Groups, Desiree Van Iersel

Discussions

No abstract provided.

Faculty Spotlight: Dr. Paul Iversen, Ryan Tatton

Discussions

No abstract provided.

[Discussions] Vol. 14 Iss. 4

Discussions

No abstract provided.

Euthanasia: A Cross-Cultural Analysis Of Right-To-Die Organzations And Euthanasia Legislature In The Netherlands And United States, Anjana Renganathan

Discussions

No abstract provided.

An Analysis Of Vaccine Hesitancy In The United States: Contributing Factors And Healthcare Response, Hannah Kent

Discussions

No abstract provided.

Exploring The Differences Between Bilinguals And Monolinguals In Non-Communicative Spatial Perspective-Taking Tasks, Shira Yellin

Discussions

No abstract provided.

Faculty Spotlight: Dr. Lee Hoffer, Viral Mistry

Discussions

No abstract provided.

[Discussions] Vol. 13 Iss. 3

Discussions

No abstract provided.

Flight Of The Eagle: Kawanabe Kyosai And His Influences, Jaques Gillis

Discussions

No abstract provided.

The Downside Of The Economic Miracle: China’S Economic Reform And The Increase In Sex Trafficking, Alexandra Sakellariou

Discussions

No abstract provided.

Force Dynamics In Political Discourse, Lauren Lucente

Discussions

No abstract provided.

Re-Fashioning The Field: On Gender And Computer Science, Jessica Nash

Discussions

No abstract provided.

Faculty Spotlight: Dr. Jessica Fox

Discussions

No abstract provided.

Cover And Forewords, Steven M. Schnell

The Geographical Bulletin

Cover and Forewords

Volume 52-2 Complete Issue, Steven M. Schnell

The Geographical Bulletin

Volume 52-2 Complete Issue

Interview: Jason Dittmer Interviewed By Steven M. Schnell, Editor, The Geographical Bulletin, Steven M. Schnell

The Geographical Bulletin

Jason Dittmer is from Jacksonville, Florida, received his PhD from Florida State University in 2003, and has taught at University College London in the United Kingdom since 2007. He is the author of Popular Culture, Geopolitics, and Identity (Rowman and Littlefield, 2010) and the co-editor of Mapping the End Times: American Evangelical Geopolitics and Apocalyptic Visions (Ashgate, 2010). He is married to the lovely Stephanie and has two cats. They all live in southeast London.

Increasing Public Participation In Municipal Solid Waste Reduction, Elizabeth J. O’Connell

The Geographical Bulletin

Municipal solid waste (MSW) presents environmental, social, and economic problems. Enlisting the public in reducing MSW has proven to be difficult in a variety of cultures and economies. Although the waste diversion practice of recycling is well-known, other waste minimization behaviors remain unknown and unpracticed by the majority of the population. There is room for improvement in waste minimization and waste diversion participation. This paper examines research into what motivates and what hinders participation in waste diversion and minimization practices by drawing out the common factors found in a wide spectrum of studies. Fear of the actual and perceived dangers …

Teaching Effectively And Efficiently: Strategies For Graduate Students, Zia Salim

The Geographical Bulletin

Teaching represents the moment at which graduate students reverse roles and take on the responsibility of educating others. Although having the opportunity to teach can greatly enhance the graduate student experience, for many graduate students a teaching assignment can entail having to find a balance between the competing demands of coursework, research, teaching, and their personal lives. This article begins with a description of some of the responsibilities that face graduate students who teach. The article then provides a variety of specific strategies that can help graduate students teach more effectively and efficiently, and concludes with brief thoughts on how …

Graduate Student Life In A Post-9/11 World: An Indian Graduate Student's Reflection In Finding Sanity And Staying With It, Aswin Subanthore

The Geographical Bulletin

The everyday lives of international graduate students are often assumed to be similar to their American-born colleagues and therefore rendered invisible. In a post-9/11 America, juggling various uncertainties including social conservatism in small college towns and immigration restrictions on employment can truly test the limits of an international graduate student’s sanity. However, student resources including international student groups can provide the space for a more comfortable dialogue between them and their American peers as well as among international students. This essay highlights some of the issues I have faced as an Indian graduate student, and provides pointers for other international …

Who Are You Married To? Balancing Graduate School And Marriage, Chris Labosier, Anna Labosier

The Geographical Bulletin

Stress is prevalent among graduate school students. Many universities and departments place a heavy burden upon their graduate students to complete large amounts of coursework, teach labs, grade student work, present at conferences, perform research for faculty, and many other responsibilities. Married graduate students face the competing demands of being both a graduate student and a spouse. This paper is a brief reflection on what it is like to be both a married graduate student and the spouse of a graduate student, a perspective rarely examined. Through these two perspectives, some coping strategies are identified. While competing demands are certainly …

Blissful Blundering: Embracing Deficiency And Surviving Graduate School, Emily Pabst

The Geographical Bulletin

Pursuing a graduate degree is often accompanied by overwhelming demands and expectations. When success is measured by one’s ability to develop a narrowed and exhaustive expertise, underdeveloped skills and deficiencies are often devalued and eschewed. T hough academia espouses lifelong learning, discordantly, it is not easily accepting of ignorance or inadequacy. This dismissal and rejection of inability furthers the unrealistic expectation of consummate mastery, exacerbating an already stressful situation and leading a person to isolate themselves from his or her ultimately inescapable ineptitudes. T hrough acceptance and engagement, inadequacies can be transformed from oppressive aggravations into pleasurable relaxations. Embracing one’s …

Can We Get A Pub From This? Reflections On Competition And The Pressure To Publish While In Graduate School, Nicholas Jon Crane, Zoe Pearson

The Geographical Bulletin

It is widely acknowledged that graduate students feel increasing pressure to be academically productive in measurable ways, notably through peer-reviewed publication. Many suggest that the drive for measurable productivity responds to changing structural constraints. In these reflections, we indicate that an unsupportive culture of graduate study is also shaped by our everyday actions. Our practices maintain and exacerbate the competition through which the drive to demonstrate propensity for academic productivity has arisen, and it is therefore at the level of practices that this culture might be changed. Through intra- and inter-university communication, we might alter the expectations within which we …