Digital Commons Network^™

Retinoblastoma Malignance And Exosome Mechanisms Facilitating Optic Nerve Head Metastatic Niche Formation, Cui Shi

Dissertations, Theses, and Capstone Projects

Retinoblastoma (RB) is a rare pediatric ocular tumor that occurs before five years of age and it is the most common intraocular cancer of childhood with more than 300 children in the United States and 8000 diagnosed globally each year. RB arises from the proliferation of cone photoreceptor precursor cells in the retina as a result of mutations in the RB1 gene. The influence of RB secreted factors on cells in the retinal environment has not been fully elucidated. Cancer cell released exosomes have been shown to transform their microenvironment through transfer of metastasis promoting molecular cargo. Cancer cell extracellular …

The Film, The Stadium And The Jail: The Post-Industrial Transformation Of Downtown Durham, Seth Rose

Dissertations, Theses, and Capstone Projects

By the late 1980s, Durham, North Carolina’s downtown-based industrial economy had been replaced by a powerful knowledge economy in the city’s peripheries. Downtown Durham’s vast array of tobacco and textiles manufacturing buildings stood empty, along with most of its commercial spaces, offices and sidewalks. This thesis argues that the local development of two major public works, a baseball stadium (the Durham Bulls Athletic Park) and a jail (the Durham County Detention Center), conceived and constructed on similar timelines in close physical proximity, was indicative of how—and for whom—city and county officials envisioned a revitalized downtown. The first chapter examines the …

The Effects Of Environmental Changes On The Biodiversity And Macroecological Patterns Of Bird Assemblages In The United States, Marlen Acosta Alamo

Dissertations, Theses, and Capstone Projects

The current restructuring of species assemblages and global loss of biodiversity result from species-specific responses to anthropogenic changes in climate and land cover. I investigated the effect of these two drivers on the seasonal distribution and biodiversity of birds in the United States and how human-induced habitat loss impacts macroecological patterns such as the species-area and the abundance-occupancy relationships. In Chapter 1, I examined the existence of a correlation between breeding and wintering geographic distributions of birds with different migratory strategies and the effect of changes in climate and the proportion of crop-pasture and urban land cover on this correlation. …

A Machine Learning Approach To Discovering Physical Models Of Galaxy Formation, Festa Bucinca

Dissertations, Theses, and Capstone Projects

Galaxies are the breathtakingly beautiful starry islands of the Universe. The process of galaxy formation involves the transformation from simple initial conditions in the early Universe to the complex galaxy structures we observe today. Spanning an immense spatial range and tremendous time scales - from the vastness of the Universe to the scale of individual stars - the physics of galaxy formation is both complex and crucial for understanding the Universe we live in. However, despite significant advancements, our theoretical understanding of galaxy formation remains incomplete.

In the era of big data available from hydrodynamical simulations and observations, Machine Learning …

Structural Insights Into Bacterial Helicase Loading At A Replication Origin By Cryogenic Electron Microscopy, Abhipsa Shatarupa

Dissertations, Theses, and Capstone Projects

DNA replication is a meticulously regulated and intricate process crucial for cellular viability. Replicative helicases, essential for unwinding DNA during replication, rely on helicase loader proteins for efficient loading and assembly at replication origins. In Escherichia coli, the replicative helicase DnaB forms a complex with six copies of the bacteriophage Lambda λP loader, resulting in a B₆P₆ conformation. The conformation of the BP complex, with a 6:6 stoichiometry, indicates that the isolated DnaB is initially captured by λP (B₆P₆) through its carboxy-terminal domain lassos/grappling hooks, serving as an early intermediate before transitioning …

Variability In Associations Among Seabirds And Marine Mammals: Causes And Consequences, Samantha A. Monier

Dissertations, Theses, and Capstone Projects

Marine predators today face multifaceted stressors from changing climate to changing prey availability, and these changes are occurring at unprecedented speeds. Any alteration to a species’ environment has the potential to disrupt social networks and thus, how animals obtain and transfer information. Interspecific social interactions in the form of local enhancement and facilitation are a critical, but not yet well-understood, component of seabird foraging; of immediate concern is that anthropogenic changes may be altering the quantity and quality of positive species interactions, with consequences for the species involved.

While we know these interactions are not immutable, less is known about …

Bodies That Traverse: Colonial Fantasies Of Oriental Incorporations In Late Medieval England, Soojung Choe

Dissertations, Theses, and Capstone Projects

“Bodies that Traverse: Colonial Fantasies of Oriental Incorporations in Late Medieval England” shows how a picture of a proto-colonialist England arises from popular romances of the period, particularly those featuring the Crusades and the “Orient,” or the fictional Near East, as its central narrative locus. While the historical Crusades to the Holy Land mainly took place between the eleventh and twelfth centuries, English fictional writing on the Crusades flourished in the “post-crusade” period of 1200–1450. My project argues that the Orient in these writings, especially popular vernacular romances, serves as a colonial ‘contact zone,’ a fetishized site for England to …

Active Galactic Nuclei - The Arrhythmic Beat Of A Galactic Heart, Henry James Best V

Dissertations, Theses, and Capstone Projects

Active Galactic Nuclei (AGN) are generally believed to be supermassive black holes (SMBHs) at the center of galaxies which are actively accreting material from the host galaxy. Through this process, they emit radiation across the electromagnetic spectrum both as a smooth continuum and emission lines. However, there is a great variety of the signals we observe–some faint, some bright, some variable and others steady. The wide array of signals produced by AGN is believed to encode both the geometry and the physics surrounding these SMBHs, making them a valuable target for understanding the high gravity limit, their feedback mechanisms to …

Winning The War While Losing Their Souls: The Crisis Of Honor And Discipline Within The French Army In Algeria, Thomas A. Schellhammer

Dissertations, Theses, and Capstone Projects

From 1939 to 1962, the French military fought in continuous conflicts. In 1961, in the midst of the Algerian War, these wars would result in military coup attempts and mutiny, as well as the formation of a breakaway terrorist group of army officers known as the Organisation de l’Armée Secrete (OAS), dedicated to the political overthrow and assassination of President of France Charles de Gaulle. While both the insurrectionists and the OAS and its adherents were ultimately unsuccessful, for members of a stable, functioning military to even contemplate such dire political action, these events illustrated a profound breach of military …

Historiography Of The Body And Corporeality In Indonesian Theatre: The Search For Decolonial Aesthetics, Mohamad Ugoran Prasad

Dissertations, Theses, and Capstone Projects

A study on Indonesian theatre historiography, this dissertation explores how and why the body and corporeality serve as the dominant means of theatre-making in Indonesia. Tracing and locating the bodily practice in theatre and performance from Indonesian independence until the turn of the twenty-first century, it locates the frictional relationship between the body and corporeality with modernity and the coloniality of language. That friction occurs in the process of adapting and translating modern theatre in the 1950s as much as during the heyday of folk popular theatre in the 1960s, preferring the body and corporeality as a refuge from ideological, …

Understanding Primate Immunity To African Trypanosomes Through The Characterization Of Trypanosome Lytic Factor Formation And Function, Sara Fresard

Dissertations, Theses, and Capstone Projects

African trypanosomes cause an annual loss of over 1 billion USD due to their economic and agricultural burden in Sub-Saharan Africa. These parasites are unicellular, extracellular parasites, that infect humans, cattle, and other livestock. Humans and some non-human primates are protected against most species of trypanosomes due to an innate immunity factor, Trypanosome Lytic Factor (TLF). This modified High Density Lipoprotein (HDL) contains two unique proteins, Haptoglobin Related Protein (HPR), a ligand to a trypanosome surface receptor, and Apolipoprotein-L1 (APOL1), the lytic component. Our overall goal is to use our understanding of primate immunity to create genetically modified cattle that …

Intimate Partner Violence And Negotiation During Covid-19: Stressors, Resources, And Perception, Victoria P. Diamond

Dissertations, Theses, and Capstone Projects

Intimate partner violence (IPV) is a serious public health concern that affects millions across the globe. The COVID-19 pandemic created unforeseen stress, and necessitated safety policies that required social isolation, often extended exposure to one’s intimate partner, and an inability to access stress-reduction resources. These factors, along with many others, lead to an abrupt increase in IPV in many couples. Using the couple-adapted family stress model (ABCX), the current study examines both previously defined (e.g., emotional dysregulation, stress, unemployment, communication issues) and COVID-19 specific risk (e.g., quarantine, unprecedented social isolation, fear of contracting COVID-19) and protective factors (e.g., meaning in …

Future Land, Futures Lost: Planning The Crisis On The Louisiana Coast, Sheehan Moore

Dissertations, Theses, and Capstone Projects

South Louisiana is rapidly losing coastal land to the combined forces of subsidence, sea-level rise, and worsening storms, accelerated by the effects of flood control engineering and extractive industrial development. With erosion threatening homes and industry alike, the state has marshaled a response on a massive economic and geographic scale: its Coastal Master Plan recommends $50 billion in river sediment diversions, barrier island restoration, and other projects over fifty years. This dissertation is about the emergence of Louisiana’s coast as a place from this knot of human and environmental relations, as an object for governance and a container for political …

The Beautiful And The Bullshit: Speaker And Listener Mental Representations Influence Bullshit Receptivity, Ryan Tracy

Dissertations, Theses, and Capstone Projects

Bullshit is a topic that has enjoyed an explosion of attention in both cognitive and social psychological research domains. While the picture painted thus far suggests that receptivity to such statements (i.e., perceiving meaning where none exists) hinges upon an individual’s ability to engage in reflective (vs. reflexive) cognitive processing, little attention has been paid to how purveyors of bullshit influence one’s willingness to engage with the message. This is critical to explore, given the status of misinformation in today’s media climate. A critical step involved in determining characteristics of speakers that predict bullshit receptivity is to understand how people …

Some New Properties Of Random Groups In The Density And Few-Relator Models, Anastasiia Chorna

Dissertations, Theses, and Capstone Projects

In this dissertation, we delve into the subjects that lie in the intersection of random group theory and first-order theory, or as traditionally referred to in the field, the first-order theory of free groups (Sela (2006) and Kharlampovich and Myasnikov (2006), among others). In particular, we establish the following two findings. First, we demonstrate that for fixed k > 2, among finitely generated groups, those without finite index subgroups of index k are prevalent in the density model (as discussed in Chapter 3). Second, we show that a first-order universal sentence in the language of groups is almost surely true in …

The Epigenetic Impact Of Dietary Choline On Growth Outcomes Of Children Exposed To Gestational Diabetes Mellitus, Ismail Kadam

Dissertations, Theses, and Capstone Projects

Maternal insulin resistance and hyperglycemia lead to gestational diabetes mellitus (GDM) which can cause fetal hyperinsulinemia, ultimately leading to excessive fetal growth associated with macrosomia and increased adiposity at birth. Increased placental macronutrient transport and epigenetic changes in growth and metabolic genes affected by GDM contribute to fetal overgrowth and can result in complications such as overweight/obesity, insulin resistance/type 2 diabetes, cardiovascular disease risk factors, as well as cognitive impairment later in life. Choline, an essential nutrient, participates in lipid and energy metabolism by providing methyl groups for DNA methylation and thus may overcome the hypomethylation of growth and metabolic …

Cognitive Flexibility And Stability In Bilingual Older Adults, Lia Pazuelo

Dissertations, Theses, and Capstone Projects

Lifelong bilingual individuals develop expertise in language-switching, requiring a delicate balance between cognitive stability—safeguarding goals from interference—and cognitive flexibility—adapting goals to changing demands. While some studies demonstrate the transferability of these skills to non-linguistic tasks, signifying bilingualism's impact on cognitive processes, others find no direct correlation between non-linguistic task-switching and bilingualism. Our study investigated the cognitive processes underlying bilingual speakers' performance on a switching task, exploring whether varying degrees of bilingual experience in older adults result in different tendencies towards stability (e.g., lower mixing cost and response congruency effect) or flexibility (e.g., smaller switching costs). By treating the bilingual experience …

Establishing A Murine Model Of Malaria-Associated Acute Kidney Injury And Demonstrating The Contribution Of Extrinsic Apoptosis To Tubular Necrosis, Johanna Bensalel-Lyampe

Dissertations, Theses, and Capstone Projects

Malaria-associated acute kidney injury (MAKI) is a form of severe malaria (SM), which is usually caused by Plasmodium falciparum infection. Until recently, the impact of this particular complication of SM was severely underestimated and research in this area has been neglected. There is in fact a high prevalence (40-60%) of MAKI in SM patients and the associated risk of mortality and development of comorbidities is high. Furthermore, pediatric patients that recover often develop long-term complications such as chronic kidney disease or neurocognitive defects. The need for adjunctive therapies and early diagnostic biomarkers specific to this SM complication is critical but …

Living Color: Aesthetic Surfaces And Political Life In Brazil, Samuel E. Novacich

Dissertations, Theses, and Capstone Projects

This dissertation is about the manipulation of appearances – of both the human body and the built environment – in Rio de Janeiro, Brazil. Focused on Afro-aesthetic makeup and tanning practices as well as urban renewal projects, this ethnographic study reveals how the making over of both the skin and the urban landscape shape social inequalities and contribute to productions of race, gender, and national belonging. While some of the aesthetic technologies examined herein may be characterized as “bottom up” – or as the self-fashioning tactics of marginalized Afro-Brazilians – others constitute “top down” infrastructural interventions led by the state …

Just Transitions: Critical Exploration Of Environmental Policy And Decision-Making Through The Lens Of Lived Stories, Mariya Marinova

Dissertations, Theses, and Capstone Projects

This research explores perspectives on just transition, what transitional policies and practices are already set in motion, the conditions necessary to achieve it, and how this knowledge can inform environmental policy. Focusing on West Virginia, it employs qualitative methodology with open-ended interviews and develops life sketches of transitions to demonstrate how deeply intertwined just transition is with the lives of the people in places marked by extractive industries. Combining guiding principles from environmental and landscape justice, energy justice, feminist energy systems framework, and place attachment theory, the findings reveal that just transitions need to be transformative, focusing on understanding how …

Misrecognition And Misrepresentation: A Critical Analysis Of The Trajectory Of Migrant Students - F1 Students, In The U.S., Domitila Dos Santos Bicudo

Dissertations, Theses, and Capstone Projects

The influx of migrant students in the United States is reported to have increased considerably between 2022 and 2023. They are a significant asset to higher education in the U.S. and are authorized to study by the Department of Homeland Security. Despite their migratory legality, restrictions in their category as F1 students place them in a position of significant vulnerability and injustice This research analyzed how migrant students navigated and negotiated their mobility from the beginning to the end of their F1 visa status, examining their perseverance in staying on a challenging pathway toward a different migratory status or a …

Competitive And Noncompetitive Credit Assignment To Reward Cues In The Lateral Orbitofrontal Cortex, Mihwa Kang

Dissertations, Theses, and Capstone Projects

This dissertation investigates the mechanisms underlying variations in credit assignment to reward cues, with a focus on the lateral orbitofrontal cortex (lOFC). The lOFC has long been implicated in signaling reward expectancies, with controversy as to whether it signals the economic value of future outcomes, their sensory features to guide behavior or both. However, whether the lOFC signals the relative (competition-dependent) or absolute (contiguity-dependent) credit of cues is unknown. To address this, I employed a combination of novel behavioral assays, in-vivo electrophysiological recordings and optogenetic stimulation in rats. In Chapter 2, I tested the suitability of a self-initiating variant of …

“Hattak Vpi Homma” Mvt Miha Nanta Fehna? What Does “Native American” Really Mean?, Alex R. Steers-Mccrum

Dissertations, Theses, and Capstone Projects

Indigenous identities in North America are much more complex than generally assumed. No single definition of “Native (American),” “(American) Indian,” or related terms provides a set of necessary and sufficient conditions that accurately or usefully describe all and only the right individuals and communities. I argue that understanding Native identities in the contemporary context requires examining multiple interconnected dimensions of Nativeness, articulated here as Enrollment and Recognition, Tribal Ethnicities, Native Race, Indian Panethnicity, and Indigenous Nationhood.

In the U.S., Indigenous identities are usually oversimplified as either Enrollment in a Recognized Tribe or as Native Race. While both of these aspects …

Meconium: A Potential Means To Predicting Later-Life Cognition, Leah Duran

Dissertations, Theses, and Capstone Projects

Maternal perinatal stress is a commonly experienced, yet chronically undiagnosed condition (CDC, 2010). Literature has suggested that perinatal stress exposure has long lasting implications of the developing child both physically and mentally (Behrman et al., 2007; Hobel et al., 2008; Bowman et al., 2004; Polanska et al., 2017; Van de Bergh et. al, 2020). The use of meconium in the clinical setting has become one that serves a purpose of detection in medical conditions like in utero drug exposure. Using meconium as a predictor for brain behavior, however, is still an emerging concept in the literature. It is quickly gaining …

Interplay Of Magnetic Impurities And Superconductivity In Topological Materials, Didier Ndengeyintwali

Dissertations, Theses, and Capstone Projects

The interplay of superconductivity and magnetism has been a long-standing topic of interest since the discovery of superconductivity. In recent years it has been shown that topological superconductivity, which has promising applications such as in topological quantum computing, could result from such interplay. Motivated by the later results I study the effect of magnetic impurities in superconducting doped topological insulators, such as Iron based topological superconductors. I show that topological character of parent materials could lead to modifications in the structure of magnetic impurity induced in-gap states. Moreover, the superconductivity induced interaction between magnetic impurities in doped topological insulator would …

The Truth And Other Fictions: The Nuance Of Truth In Medieval Literature, Mark-Allan Donaldson

Dissertations, Theses, and Capstone Projects

This dissertation, “The Truth and Other Fictions,” is an exploration of the functional relationship between fiction and truth. It discusses truth as a type of nuanced information which may exist in a variety of forms (i.e., objective truth, narrative truth, emotional truth, cultural truth, etc.) and explores how these truths may be created or communicated through the medium of literature. The dissertation also explores how fiction, either narrative or structural, assists in said creation and communication of truth and in some cases is the necessary component to these processes. The Middle Ages and its literature provide the ideal staging ground …

“Community Thinking Spaces”: Exploring The Openings And Possibilities Of A School-Based Intergenerational Community Of Practice, Lucy A. Robins

Dissertations, Theses, and Capstone Projects

This exploratory case study examines the possibilities of creating generative, collaborative, intergenerational learning communities within a traditional public 6-12 school in the United States, as an antidote to the ideologies of adultism, systems of whiteness, and settler colonial logics. The study is situated within a single public school site, where I have been a science teacher and teacher leader for the past eight years. The school, which self-identifies as a “progressive” public school, serves to reify the history of schools as sites for control through what I term a “we know best” ideology. This ideology serves to dismiss and devalue …

The Seat Of Singular Gene Choice: Dissecting The Role Of Odorant Receptor Enhancer Elements That Lead To Mammalian Olfactory System Expression, Alessandro M. Rosa

Dissertations, Theses, and Capstone Projects

Odorant receptors (ORs) were first identified in 1991 and the initial data strongly suggested that ORs were part of a large superfamily of G-protein-coupled receptors. Within a few years of the discovery of the OR superfamily, it became clear that each OR allele was exclusively expressed in olfactory sensory neurons (OSN), and that this singular expression leads to cellular identity. Many studies over the past thirty years have sought to unlock the mysteries of the mechanism for monoallelic and monogenic OR gene activation and expression in OSNs, however no definitive model for singular gene expression has emerged.

Using a series …

Brain Injury And Psychosocial Trauma: Outcomes Among Justice-Involved Individuals, Mahathi D. Kosuri

Dissertations, Theses, and Capstone Projects

Justice-involved individuals experience disproportionately high rates of both traumatic brain injuries (TBI) and psychosocial traumas. However, these traumas have yet to be conceptualized together, leaving a chasm of research on how they interact and influence this population. The current study was the first to measure the effects of TBIs as well as psychosocial trauma among justice-involved men, within the context of executive functioning, history of justice involvement, and recidivism. A sample of men (N=95) from a private correctional facility were given the Ohio State University Traumatic Brain Injury Questionnaire (OSU-TBI-ID), the Lifetime Stressor Checklist- Revised (LSC-R), along with …

Ethnoracial Inequality In Egalitarian Sweden: Swedish Exceptionalism And Racial Legacies, Beiyi Hu

Dissertations, Theses, and Capstone Projects

Ethnoracial Inequality in Egalitarian Sweden: Swedish Exceptionalism and Racial Legacies investigates the persistence of ethno-racial disparities in Sweden, a country often celebrated for its humanitarianism, egalitarianism, and tolerance. I explore several key questions: How do ethnic and racial minorities, as well as majority Swedes, perceive and understand race and ethno-racial inequalities in a country that does not officially recognize race? What sociohistorical legacies and institutionalized practices have contributed to contemporary ethnoracial inequalities in Sweden? And for ethnic and racial minorities, what are their day-to-day experiences of racism? Combining analysis of governmental data and in-depth interviews as well as exploratory spatial …