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Articles 328951 - 328980 of 5161263
Full-Text Articles in Entire DC Network
Salary Report, 2024 September, Eastern Michigan University
Salary Report, 2024 September, Eastern Michigan University
EMU Salary Reports
No abstract provided.
A History Of The Usda Forest Service Aviation Program : Firefighting Missions, United States Forest Service
A History Of The Usda Forest Service Aviation Program : Firefighting Missions, United States Forest Service
Books on Smokejumping
This United States government publication is a history of the many uses of aviation personnel and equipment by the United States Forest Service from the first request for aerial reconnaissance in 1919 to developments in infrared technology from the 1990s forward. Of particular interest to this collection is Chapter 4, which focuses on the history of smokejumping in the United States Forest Service.
This publication was originally posted online by the United States Forest Service. Other documents may be found through their publications site at: https://www.fs.usda.gov/about-agency/publications.
Shareholder Agreements In India: An Unsettled Jurisprudence., Vikramaditya S. Khanna
Shareholder Agreements In India: An Unsettled Jurisprudence., Vikramaditya S. Khanna
Book Chapters
Shareholder agreements (SAs) are becoming more common around the world as the ownership of companies become more concentrated. Larger investors— in particular, private equity investors— often document their understandings about their investments in increasingly sophisticated SAs. India has also witnessed a rise in SAs, usually with foreign private equity players, which reflects a level of sophistication and formality in contract negotiations that was not always present when such agreements were between family or affinity groups. This has placed increasing pressure on Indian case law to evolve in response to these agreements.
This chapter explores that response and finds that it …
Environmental Contributions To Cognitive Development: The Role Of Cognitive Stimulation, Divyangana Rakesh, Katie A. Mclaughlin, Margaret Sheridan, Kathryn L. Humphreys, Maya L. Rosen
Environmental Contributions To Cognitive Development: The Role Of Cognitive Stimulation, Divyangana Rakesh, Katie A. Mclaughlin, Margaret Sheridan, Kathryn L. Humphreys, Maya L. Rosen
Neuroscience: Faculty Publications
Early environmental experiences influence children's cognitive and neural development. In particular, cognitive stimulation, defined as environmental inputs that engage the senses and provide learning opportunities for children, fosters acquisition of knowledge across various cognitive domains. Low levels of cognitive stimulation in early life may restrict learning opportunities, contributing to lasting consequences for neural development and later academic and occupational achievement. This review delves into the role of cognitive stimulation in neural development and related cognitive performance, available tools for measuring cognitive stimulation in various settings, and offers insights into future research directions. In addition, variability in cognitive stimulation, often linked …
2024-September-01-Meet Dr. Shelby Brooks Assistant Professor Of Pharmacy Practice, Bill Gatton College Of Pharmacy, East Tennessee State University, University Marketing And Communication, East Tennessee State University
2024-September-01-Meet Dr. Shelby Brooks Assistant Professor Of Pharmacy Practice, Bill Gatton College Of Pharmacy, East Tennessee State University, University Marketing And Communication, East Tennessee State University
ETSU News
Listen to her interview on our college podcast, White Coat Radio.
(Sept. 1, 2024)—ETSU Bill Gatton College of Pharmacy welcomes Dr. Shelby Brooks, from Asheville, North Carolina, who is serving as Assistant Professor of Pharmacy Practice. Her clinical interests include cardiology (specifically anticoagulation/antiplatelets, post stroke management, dyslipidemia, and coronary artery disease), cirrhosis management, and pharmacy resident training.
Brooks graduated from the University of Tennessee College of Pharmacy in 2019 then went on to complete a 24-month Pharmacotherapy Residency Program at the University of Tennessee Medical Center. During her time in residency, she focused on inpatient and outpatient family medicine practice, …
2024-September-01-Meet Kaitlyn (Phillips '22) North Assistant Professor Of Pharmacy Practice, Bill Gatton College Of Pharmacy, East Tennessee State University, University Marketing And Communication, East Tennessee State University
2024-September-01-Meet Kaitlyn (Phillips '22) North Assistant Professor Of Pharmacy Practice, Bill Gatton College Of Pharmacy, East Tennessee State University, University Marketing And Communication, East Tennessee State University
ETSU News
Listen to her interview on our college podcast, White Coat Radio.
(Sept. 1, 2024)—Dr. Kaitlyn (Phillips '22) North is from Erwin, Tennessee, and graduated from the Class of 2022. She is an Assistant Professor in Pharmacy Practice and in the Department of Family Medicine at James H. Quillen College of Medicine specializing in chronic disease state management and primary care.
North is serving as a clinical pharmacist faculty member at ETSU Family Physicians of Kingsport. She completed her postgraduate training at an ambulatory care-focused PGY1 residency program at Tandem Health--University of South Carolina, and the PGY2 residency program in Ambulatory …
Birds Of A Feather: Resolving Stellar Mass Assembly With Jwst/Nircam In A Pair Of Kindred Z ∼ 2 Dusty Star-Forming Galaxies Lensed By The Plck G165.7+67.0 Cluster, Patrick S. Kamieneski, Brenda L. Frye, Rogier A. Windhorst, Kevin C. Harrington, Min S. Yun, Allison Noble, Massimo Pascale, Nicholas Foo, Seth H. Cohen, Rolf A. Jansen, Timothy Carleton, Anton M. Koekemoer, Christopher N.A. Willmer, Jake S. Summers, Nikhil Garuda, Reagen Leimbach, Benne W. Holwerda, Justin D.R. Pierel, Eric F. Jiménez-Andrade, S. P. Willner, Belén Alcalde Pampliega, Amit Vishwas, William C. Keel, Q. Daniel Wang, Cheng Cheng, Dan Coe, Christopher J. Conselice, Jordan C.J. D’Silva, Simon P. Driver, Norman A. Grogin, Tyler Hinrichs, James D. Lowenthal
Birds Of A Feather: Resolving Stellar Mass Assembly With Jwst/Nircam In A Pair Of Kindred Z ∼ 2 Dusty Star-Forming Galaxies Lensed By The Plck G165.7+67.0 Cluster, Patrick S. Kamieneski, Brenda L. Frye, Rogier A. Windhorst, Kevin C. Harrington, Min S. Yun, Allison Noble, Massimo Pascale, Nicholas Foo, Seth H. Cohen, Rolf A. Jansen, Timothy Carleton, Anton M. Koekemoer, Christopher N.A. Willmer, Jake S. Summers, Nikhil Garuda, Reagen Leimbach, Benne W. Holwerda, Justin D.R. Pierel, Eric F. Jiménez-Andrade, S. P. Willner, Belén Alcalde Pampliega, Amit Vishwas, William C. Keel, Q. Daniel Wang, Cheng Cheng, Dan Coe, Christopher J. Conselice, Jordan C.J. D’Silva, Simon P. Driver, Norman A. Grogin, Tyler Hinrichs, James D. Lowenthal
Astronomy: Faculty Publications
We present a new parametric lens model for the G165.7+67.0 galaxy cluster, which was discovered with Planck through its bright submillimeter flux, originating from a pair of extraordinary dusty star-forming galaxies (DSFGs) at z ≈ 2.2. Using JWST and interferometric mm/radio observations, we characterize the intrinsic physical properties of the DSFGs, which are separated by only ∼1″ (8 kpc) and a velocity difference ΔV ≲ 600 km s−1 in the source plane, and thus are likely undergoing a major merger. Boasting intrinsic star formation rates SFRIR = 320 ± 70 and 400 ± 80 M ⊙ yr−1, stellar masses of …
Detailed Study Of A Rare Hyperluminous Rotating Disk In An Einstein Ring 10 Billion Years Ago, Daizhong Liu, Natascha M. Förster Schreiber, Kevin C. Harrington, Lilian L. Lee, Patrick S. Kamieneski, Richard I. Davies, Dieter Lutz, Alvio Renzini, Stijn Wuyts, Linda J. Tacconi, Reinhard Genzel, Andreas Burkert, Rodrigo Herrera-Camus, Belén Alcalde Pampliega, Amit Vishwas, Melanie Kaasinen, Q. Daniel Wang, Eric F. Jiménez-Andrade, James Lowenthal, Nicholas Foo, Brenda L. Frye, Jinyi Shangguan, Yixian Cao, Guido Agapito, Alex Agudo Berbel, Capucine Barfety, Andrea Baruffolo, Derek Berman, Martin Black, Marco Bonaglia, Runa Briguglio, Luca Carbonaro
Detailed Study Of A Rare Hyperluminous Rotating Disk In An Einstein Ring 10 Billion Years Ago, Daizhong Liu, Natascha M. Förster Schreiber, Kevin C. Harrington, Lilian L. Lee, Patrick S. Kamieneski, Richard I. Davies, Dieter Lutz, Alvio Renzini, Stijn Wuyts, Linda J. Tacconi, Reinhard Genzel, Andreas Burkert, Rodrigo Herrera-Camus, Belén Alcalde Pampliega, Amit Vishwas, Melanie Kaasinen, Q. Daniel Wang, Eric F. Jiménez-Andrade, James Lowenthal, Nicholas Foo, Brenda L. Frye, Jinyi Shangguan, Yixian Cao, Guido Agapito, Alex Agudo Berbel, Capucine Barfety, Andrea Baruffolo, Derek Berman, Martin Black, Marco Bonaglia, Runa Briguglio, Luca Carbonaro
Astronomy: Faculty Publications
Hyperluminous infrared galaxies (HyLIRGs) are the rarest and most extreme starbursts and found only in the distant Universe (z ≳ 1). They have intrinsic infrared (IR) luminosities LIR ≥ 1013 L⊙ and are commonly found to be major mergers. Recently, the Planck All-Sky Survey to Analyze Gravitationally-lensed Extreme Starbursts project (PASSAGES) searched ~104 deg2 of the sky and found ~20 HyLIRGs. We describe a detailed study of PJ0116-24, the brightest (μLIR ≈ 2.6 × 1014 L⊙, magnified with μ ≈ 17) Einstein-ring HyLIRG in the southern sky, at z = 2.125, with observations from the near-IR integral-field spectrograph VLT/ERIS and …
Outsourcing Electricity Market Design, Joshua C. Macey
Outsourcing Electricity Market Design, Joshua C. Macey
University of Chicago Law Review
A basic principle of virtually every regulation to improve grid reliability and reduce power sector emissions is that market participants change their behavior when regulations make it more expensive to engage in socially harmful activities. To give a concrete example, a carbon tax assumes that increasing the costs of emitting carbon dioxide will lead market participants to reduce energy consumption and switch to less carbon-intensive resources.
But this assumption does not apply to large parts of the electricity industry, where investor-owned utilities are often able to pass the costs of climate and reliability rules on to captive ratepayers. The underlying …
Mutually Assured Democracy: Cooperating Under The Compact Clause To Combat Partisan Gerrymandering, Samuel P. Leroy
Mutually Assured Democracy: Cooperating Under The Compact Clause To Combat Partisan Gerrymandering, Samuel P. Leroy
University of Chicago Law Review
No abstract provided.
Editor's Note, Joseph Drew Editor-In-Chief
Editor's Note, Joseph Drew Editor-In-Chief
Comparative Civilizations Review
Although the International Society for the Comparative Study of Civilizations was formally launched in 1961 via a scholarly conference convened in Salzburg, Austria, which brought together many of the world’s leading experts on the subject under the sponsorship of the Austrian government and UNESCO, regular annual meetings for those interested in comparative civilizations have been held subsequently by the society variously in North America, South America, Asia or Europe almost every year since that time.
Former Iscsc President Wayne Bledsoe: An Appreciation, Michael Palencia-Roth
Former Iscsc President Wayne Bledsoe: An Appreciation, Michael Palencia-Roth
Comparative Civilizations Review
About three weeks before Wayne Bledsoe died on the 2nd of June 2024, at 83, my wife Elaine and I commented to each other that we simply had to get in touch with him and Deb again, for too much time had passed since we had seen each other. We did not know that he was ill, and so the news of his death surprised and distressed us.
Cognosis And The Evolution Of Civilization, Ken Baskin
Cognosis And The Evolution Of Civilization, Ken Baskin
Comparative Civilizations Review
From the time when the complex states such as Egypt or Sumer emerged roughly 5,000 years ago, the civilizations they represent have generally become more populous, more socially varied, wealthier, and more technologically advanced. As a result, the innovations they produced would begin to change the conditions in which they existed, and their cultures have had to evolve to adapt to this ongoing change. For instance, the cultures of Bronze Age Egypt and the Iron Age Han Dynasty had to be quite different, even though both were agricultural societies. And, of course, the Electronic Age cultures of the United States …
Is Donald Trump A Modern-Day Catiline?, Jamie González-Ocaña
Is Donald Trump A Modern-Day Catiline?, Jamie González-Ocaña
Comparative Civilizations Review
Could the story of a failed Roman politician who organized a plot to seize the Roman republic in 63 BCE be a metaphor for Donald Trump’s political persona — his initial presidential run against the establishment, his rhetorical effort to overthrow the status quo and the natural order of things in national politics, the love affair Trump has always had with the struggling working-class voters (with the “forgotten” Americans), his constant testing the Constitutional limits of our republican system of government? Could both figures be symptoms of times when a republic is in crisis and reminders of the perils that …
Niccolò Longobardo And The Early Modern Encounter Of Europe With China, Yu Liu
Niccolò Longobardo And The Early Modern Encounter Of Europe With China, Yu Liu
Comparative Civilizations Review
Writing in 1962 about the founding fathers of the early modern Jesuit China mission, Jesuit historian George H. Dunne famously called them the generation of giants “who, breaking with the dominant spirit of their times and recalling a distant past, restored the concept of cultural adaptation to a central position in the world mission of Christianity.”
Seventeen Crises In Western Civilization That Have Arisen Since The Dark Ages: A Cognition Science-Oriented Approach, Andrew Targowski
Seventeen Crises In Western Civilization That Have Arisen Since The Dark Ages: A Cognition Science-Oriented Approach, Andrew Targowski
Comparative Civilizations Review
The purpose of this article is to synthesize those crises in the unfolding of Western civilization that are controlled by human knowledge and wisdom. The methodology is transdisciplinary, utilizing a cognitive science-oriented, big-picture view of civilization and main conflicts. The crises are investigated across three time periods; the Dark Ages (from the fifth to the fourteenth century), Modern Times (from the fifteenth to the twentieth century), and the present century. The findings reveal that today Western civilization faces seventeen significant crises. Knowledge is not sufficient to solve these crises; we need to employ knowledge-based wisdom. This approach presents a new …
What Lessons Can Be Learned From The United Nations Preventive Deployment Mission In North Macedonia, On The Border Of Two Civilizations: Nothing Fails Like Success?, Mary Frances Lebamoff
What Lessons Can Be Learned From The United Nations Preventive Deployment Mission In North Macedonia, On The Border Of Two Civilizations: Nothing Fails Like Success?, Mary Frances Lebamoff
Comparative Civilizations Review
Preventive deployment as a conflict prevention tool has not recurred in the past several decades, despite the broadly acclaimed success of the United Nations Preventive Deployment in Macedonia, UNPREDEP 1995-1999, and of its predecessor missions, UNPROFOR/Macedonia, and UNPROFOR/M 1992-1995.
The United Nations in particular has continued with mainly first- and second-generation peacekeeping, peacemaking and peacebuilding actions even on civilizational borders. What may best explain why there has been no other engagement in preventive deployment missions? There has been much emphasis placed formally and informally on early warning, detection, mitigation, and prevention of conflict. There have also been increasing numbers of …
Book Review: Liberalism, Realism, Or … Integralism? Perusing John J. Mearsheimer’S Book The Great Delusion, Vlad Alalykin-Izvekov
Book Review: Liberalism, Realism, Or … Integralism? Perusing John J. Mearsheimer’S Book The Great Delusion, Vlad Alalykin-Izvekov
Comparative Civilizations Review
The paper presents an analysis of the scholarly views of prominent American political scholar John J. Mearsheimer as set forth in his book The Great Delusion (Yale University Press, 2019). It also offers analysis of other existing approaches, as well as elaborates on a new Integralistic Paradigm which has a potential to integrate the field of International Relations (IR) Theory.
Amnesty Law And The State’S Obligation To Prosecute Serious Crimes: The Case Of Lebanon, Mireille Rebeiz
Amnesty Law And The State’S Obligation To Prosecute Serious Crimes: The Case Of Lebanon, Mireille Rebeiz
Denver Journal of International Law & Policy
According to the Amnesties, Conflict, and Peace Agreement dataset, 320 amnesties were adopted in the context of armed internal and international conflicts to military coups, civil unrest, and political crises since 1990: 75% of amnesties adopted were related to conflict, and 49% of peace agreements adopted in the same period included amnesty provisions.
These high numbers clearly indicate that amnesties are not a legal tool of the past, and that they continue to be widely used especially in the Global South.
In the context of transitional justice, they may be negotiated to end violence or help move from an authoritarian …
Satirical Deepfakes, Surreal Dreamscapes & Nostalgic Pixels: The Rapid Evolution And Cultural Commentary Of Ai-Aesthetics, Andrew Smith, James Hutson
Satirical Deepfakes, Surreal Dreamscapes & Nostalgic Pixels: The Rapid Evolution And Cultural Commentary Of Ai-Aesthetics, Andrew Smith, James Hutson
Faculty Scholarship
The rapid evolution of visual aesthetics driven by AI, shared globally through the internet and social media, has dramatically accelerated what once took centuries to develop. This article explores the unique visual tropes emerging from AI-generated content, characterized by surreal, uncanny, and often unsettling imagery. Examples range from the Dor Brothers' stylized narrative videos to horrifying depictions of transformations, such as people morphing into motorcycles. The article contextualizes this aesthetic within historical developments in creative experimentation, drawing parallels with David Bowie's unconventional approach to sound creation in the 1970s. It also considers how AI-driven art, free from copyright constraints in …
Ai Satire And Digital Dystopia: The Dor Brothers Crafting Imperfection And Political Commentary In Contemporary Video Art, James Hutson, Andrew Smith
Ai Satire And Digital Dystopia: The Dor Brothers Crafting Imperfection And Political Commentary In Contemporary Video Art, James Hutson, Andrew Smith
Faculty Scholarship
The Dor Brothers' AI-generated video content exemplifies an inflection point in digital creativity, where technological limitations are repurposed as aesthetic tools. Drawing on recent interviews with Yonatan Dor, this article explores the innovative techniques of the brothers, such as masking visual imperfections with retro filters and embracing the unpredictability of AI outputs. Through generating numerous clips and meticulously editing selections, they create a unique aesthetic that juxtaposes surrealism with a gritty realism, often reminiscent of early CCTV or VHS footage. Their work not only transcends the typical "morphing face" trope of AI videos but also engages in satire, using deepfake-like …
Bridging Disciplines With Ai-Powered Coding: Empowering Non-Stem Students To Build Advanced Apis In The Humanities, Daniel Plate, James Hutson
Bridging Disciplines With Ai-Powered Coding: Empowering Non-Stem Students To Build Advanced Apis In The Humanities, Daniel Plate, James Hutson
Faculty Scholarship
The integration of AI-powered coding assistants, such as Cursor AI, GitHub Copilot, and Replit’s Ghostwriter AI, represents a transformative shift in programming education, particularly for non-STEM students. These tools democratize coding by enabling natural language code generation, intelligent error correction, and context-aware assistance within familiar coding environments. This article explores how these technologies empower educators across disciplines to introduce basic and advanced coding concepts to humanities students, a demographic traditionally underserved in programming education. By leveraging AI, instructors can teach non-STEM students the foundational principles of coding and guide them through the development of sophisticated projects, such as building APIs …
Contemplating Existence: Ai And The Meaning Of Life, Emily Barnes, James Hutson
Contemplating Existence: Ai And The Meaning Of Life, Emily Barnes, James Hutson
Faculty Scholarship
This article explores the intersection of artificial intelligence (AI) with existential philosophy, examining how AI technologies influence human conceptualizations of purpose and meaning. Despite rapid advancements in AI, the domain's implications for existential thought remain underexplored. By integrating interdisciplinary perspectives from psychology, philosophy, and AI ethics, this study elucidates how AI can shape, challenge, or enhance our understanding of life's purpose. It investigates theoretical frameworks and practical implementations of AI engaging in existential questions, analyzing both the capabilities and limitations of AI systems such as ChatGPT in simulating human existential thought. The ethical implications of AI's role in existential inquiries …
Mvar: A Mouse Variation Registry., Baha El Kassaby, Francisco Castellanos, Matthew Gerring, Govindarajan Kunde-Ramamoorthy, Carol J Bult
Mvar: A Mouse Variation Registry., Baha El Kassaby, Francisco Castellanos, Matthew Gerring, Govindarajan Kunde-Ramamoorthy, Carol J Bult
Faculty Research 2024
The Mouse Variation Registry (MVAR) resource is a scalable registry of mouse single nucleotide variants and small indels and variant annotation. The resource accepts data in standard Variant Call Format (VCF) and assesses the uniqueness of the submitted variants via a canonicalization process. Novel variants are assigned a unique, persistent MVAR identifier; variants that are equivalent to an existing variant in the resource are associated with the existing identifier. Annotations for variant type, molecular consequence, impact, and genomic region in the context of specific transcripts and protein sequences are generated using Ensembl's Variant Effect Predictor (VEP) and Jannovar. Access to …
Tuberculosis In Otherwise Healthy Adults With Inherited Tnf Deficiency., Andrés A Arias, Anna-Lena Neehus, Masato Ogishi, Vincent Meynier, Adam Krebs, Tomi Lazarov, Angela M Lee, Carlos A Arango-Franco, Rui Yang, Julio Orrego, Melissa Corcini Berndt, Julian Rojas, Hailun Li, Darawan Rinchai, Lucia Erazo-Borrás, Ji Eun Han, Bethany Pillay, Khoren Ponsin, Matthieu Chaldebas, Quentin Philippot, Jonathan Bohlen, Jérémie Rosain, Tom Le Voyer, Till Janotte, Krishnajina Amarajeeva, Camille Soudée, Marion Brollo, Katja Wiegmann, Quentin Marquant, Yoann Seeleuthner, Danyel Lee, Candice Lainé, Doreen Kloos, Rasheed Bailey, Paul Bastard, Narelle Keating, Franck Rapaport, Taushif Khan, Marcela Moncada-Vélez, María Camila Carmona, Catalina Obando, Jesús Alvarez, Juan Carlos Cataño, Larry Luber Martínez-Rosado, Juan P Sanchez, Manuela Tejada-Giraldo, Anne-Sophie L'Honneur, María L Agudelo, Lizet J Perez-Zapata, Diana M Arboleda, Juan Fernando Alzate, Felipe Cabarcas, Alejandra Zuluaga, Simon J Pelham, Armin Ensser, Monika Schmidt, Margarita M Velásquez-Lopera, Emmanuelle Jouanguy, Anne Puel, Martin Krönke, Stefano Ghirardello, Alessandro Borghesi, Susanta Pahari, Bertrand Boisson, Stefania Pittaluga, Cindy S Ma, Jean-François Emile, Luigi D Notarangelo, Stuart G Tangye, Nico Marr, Nico Lachmann, Hélène Salvator, Larry S Schlesinger, Peng Zhang, Michael S Glickman, Carl F Nathan, Frédéric Geissmann, Laurent Abel, José Luis Franco, Jacinta Bustamante, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis
Tuberculosis In Otherwise Healthy Adults With Inherited Tnf Deficiency., Andrés A Arias, Anna-Lena Neehus, Masato Ogishi, Vincent Meynier, Adam Krebs, Tomi Lazarov, Angela M Lee, Carlos A Arango-Franco, Rui Yang, Julio Orrego, Melissa Corcini Berndt, Julian Rojas, Hailun Li, Darawan Rinchai, Lucia Erazo-Borrás, Ji Eun Han, Bethany Pillay, Khoren Ponsin, Matthieu Chaldebas, Quentin Philippot, Jonathan Bohlen, Jérémie Rosain, Tom Le Voyer, Till Janotte, Krishnajina Amarajeeva, Camille Soudée, Marion Brollo, Katja Wiegmann, Quentin Marquant, Yoann Seeleuthner, Danyel Lee, Candice Lainé, Doreen Kloos, Rasheed Bailey, Paul Bastard, Narelle Keating, Franck Rapaport, Taushif Khan, Marcela Moncada-Vélez, María Camila Carmona, Catalina Obando, Jesús Alvarez, Juan Carlos Cataño, Larry Luber Martínez-Rosado, Juan P Sanchez, Manuela Tejada-Giraldo, Anne-Sophie L'Honneur, María L Agudelo, Lizet J Perez-Zapata, Diana M Arboleda, Juan Fernando Alzate, Felipe Cabarcas, Alejandra Zuluaga, Simon J Pelham, Armin Ensser, Monika Schmidt, Margarita M Velásquez-Lopera, Emmanuelle Jouanguy, Anne Puel, Martin Krönke, Stefano Ghirardello, Alessandro Borghesi, Susanta Pahari, Bertrand Boisson, Stefania Pittaluga, Cindy S Ma, Jean-François Emile, Luigi D Notarangelo, Stuart G Tangye, Nico Marr, Nico Lachmann, Hélène Salvator, Larry S Schlesinger, Peng Zhang, Michael S Glickman, Carl F Nathan, Frédéric Geissmann, Laurent Abel, José Luis Franco, Jacinta Bustamante, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis
Faculty Research 2024
Severe defects in human IFNγ immunity predispose individuals to both Bacillus Calmette–Guérin disease and tuberculosis, whereas milder defects predispose only to tuberculosis1 . Here we report two adults with recurrent pulmonary tuberculosis who are homozygous for a private loss-of-function TNF variant. Neither has any other clinical phenotype and both mount normal clinical and biological inflammatory responses. Their leukocytes, including monocytes and monocyte-derived macrophages (MDMs) do not produce TNF, even after stimulation with IFNγ. Blood leukocyte subset development is normal in these patients. However, an impairment in the respiratory burst was observed in granulocyte–macrophage colony-stimulating factor (GM-CSF)-matured MDMs and alveolar macrophage-like …
Altered Rna Export By Sf3b1 Mutants Confers Sensitivity To Nuclear Export Inhibition., Sana Chaudhry, Felipe Beckedorff, Shaista Shabbir Jasdanwala, Tulasigeri M Totiger, Maurizio Affer, Abimbola Eunice Lawal, Skye Montoya, Francesco Tamiro, Olivia Tonini, Alexandra Chirino, Andrew Adams, Anya K Sondhi, Stephen Noudali, Alyssa Mauri Cornista, Miah Nicholls, Jumana Afaghani, Paola Robayo, Daniel Bilbao, Stephen D Nimer, Jose Antonio Rodríguez, Shruti Bhatt, Eric Wang, Justin Taylor
Altered Rna Export By Sf3b1 Mutants Confers Sensitivity To Nuclear Export Inhibition., Sana Chaudhry, Felipe Beckedorff, Shaista Shabbir Jasdanwala, Tulasigeri M Totiger, Maurizio Affer, Abimbola Eunice Lawal, Skye Montoya, Francesco Tamiro, Olivia Tonini, Alexandra Chirino, Andrew Adams, Anya K Sondhi, Stephen Noudali, Alyssa Mauri Cornista, Miah Nicholls, Jumana Afaghani, Paola Robayo, Daniel Bilbao, Stephen D Nimer, Jose Antonio Rodríguez, Shruti Bhatt, Eric Wang, Justin Taylor
Faculty Research 2024
SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of XPO1 inhibitors, selinexor and eltanexor, in high-risk myelodysplastic neoplasms (MDS) revealed responders were enriched with SF3B1 mutations. Given that XPO1 (Exportin-1) is a nuclear exporter responsible for the export of proteins and multiple RNA species, this led to the hypothesis that SF3B1-mutant cells are sensitive to XPO1 inhibition, potentially due to altered splicing. Subsequent RNA sequencing after XPO1 inhibition in SF3B1 wildtype and mutant cells showed increased nuclear retention of RNA transcripts and increased alternative splicing in the SF3B1 mutant cells particularly of genes that impact apoptotic …
Point Of Care Ultrasounds Obtained By Novice Physician Assistant Residents (Pocus On Par), Kristine L. Jeffers, Jared Cohen, Eric Chin, Nicholas Thompson, Seshidar Tekmal, Robyn Lombardo, Jessica Barlow, Amie Billstrom, James Aden, Melissa Myers
Point Of Care Ultrasounds Obtained By Novice Physician Assistant Residents (Pocus On Par), Kristine L. Jeffers, Jared Cohen, Eric Chin, Nicholas Thompson, Seshidar Tekmal, Robyn Lombardo, Jessica Barlow, Amie Billstrom, James Aden, Melissa Myers
Physician Assistant Studies Faculty Research and Publications
Introduction
The integration of Point of Care Ultrasound (POCUS) into the care of trauma patients, specifically the E-FAST, has improved the accuracy of initial diagnoses and improved time to surgical intervention in critically ill patients. Physician assistants (PAs) are critically important members of any military trauma resuscitation team and are often team leaders in a pre-hospital setting. They may receive training in ultrasound but there are little data to support their use or evaluate their effectiveness in using POCUS. We designed a study to evaluate the image quality of an E-FAST Exam performed by Emergency Medicine Physician Assistant (EMPA) Fellows …
Growing Oaten Hay On Frost Prone Paddocks, Department Of Primary Industries And Regional Development, Western Australia
Growing Oaten Hay On Frost Prone Paddocks, Department Of Primary Industries And Regional Development, Western Australia
Grains and other field crops factsheets
Growing oaten hay on frost-prone paddocks minimises the frost risk because it is cut soon after flowering, avoiding the frost sensitive period. If severe frost damage occurs to other crops, baling them for hay may reduce economic loss.
Oats are much more tolerant than other cereals to frost events that occur during vegetative growth and flowering.