Digital Commons Network^™

Rna G-Quadruplexes Function As A Tunable Switch Of Fus Phase Separation, Jenny L. Carey, Miyuki Hayashi, Emily A. Welebob, Laura R. Ganser, Huan Wang, Kerry Buckhaults, Jacquelyn A. Depierro, Zheng Shi, James Shorter, Sua Myong, Aaron R. Haeusler, Lin Guo

Department of Biochemistry and Molecular Biology Faculty Papers

Fused in sarcoma (FUS) undergoes liquid-liquid phase separation (LLPS) to support essential cellular functions, but aberrant phase transitions promote toxic aggregation in neurodegenerative disease. Short RNA oligonucleotides can reverse this behavior, yet the structural determinants that govern RNA activity remain poorly defined. Here, we identify RNA G-quadruplexes (rG4s) as tunable structural motifs that potently modulate FUS LLPS. rG4 activity depends on its concentration and is modulated by rG4 length and stability: increasing repeat number switches rG4s from inhibitor to nucleator of FUS assembly, whereas chemical modifications that stabilize rG4 enhance inhibitory function and render these activities resilient to ionic perturbation. …

To What Extent Could Quantum Computing Pose A Threat To Global Modern Data Security?, Aniket Maheshwari

Journal of Cybersecurity Education, Research and Practice

Quantum computing has emerged as a transformative technology with the potential to fundamentally disrupt modern cryptographic systems that underpin global data security. This paper examines the extent to which quantum computing could pose a threat to modern global data security by synthesising existing technical, institutional, and policy-oriented literature. Drawing on a narrative review of scholarly research, industry reports, and government frameworks, the analysis focuses on the implications of quantum algorithms such as Shor’s and Grover’s, which challenge the mathematical foundations of widely used cryptographic schemes. The findings suggest that while quantum computing presents a credible long-term threat to asymmetric encryption …

Skill-Based Occupational Connectivity And Local Labor Market Development, Xiaoyin Li, David H. Nason, Heather M. Stephens

Regional Research Institute Working Papers

Recent decades have witnessed significant economic transitions that have disrupted traditional economic activities and reshaped the labor force. Occupational connectivity, which captures how easily workers transition to other growing occupations, may be an important factor for local labor market resilience and development. Using county employment shares and a skill-based occupational matching matrix built upon O*NET data, this study explores how occupational connectivity affects local labor market outcomes. Our findings suggest that counties with higher levels of occupational connectivity are associated with better labor market outcomes and more stable population dynamics, even after accounting for local industry mix. These results highlight …

Enhancing Teaching Effectiveness Through Professional Development For Part-Time Nursing Faculty, Amanda Moss

Doctor of Nursing Practice Projects

Part-time nursing faculty play a vital role in nursing education; however, many institutions lack standardized professional development opportunities for part-time faculty, resulting in inconsistent preparation and teaching practices. This Doctor of Nursing Practice policy change project examined whether revising an institutional professional development policy to include part-time faculty and implementing a structured faculty development program would improve faculty preparedness, confidence, and comfort with evidence-based teaching practices and instructional strategies that support ACEN faculty development expectations. Guided by the Iowa Model–Revised of Evidence-Based Practice, Kotter’s Organizational Change Theory, and the Plan-Do-Study-Act (PDSA) framework, this quantitative policy change project was conducted over …

Parental Effects In Fall Webworm, Emma Sellers, Mykaela Tanino-Springsteen, Mayra Vidal, Dhaval Vyas, Gina Wimp, Mariana Abarca, Mattheau Comerford, Shannon Murphy

Data

The environment or experiences of a parent generation can impact the fitness of the next generation, a phenomenon known as parental effects. While a high-quality diet can directly benefit an individual and a low-quality diet can reduce fitness, a parental effect occurs only when there is a transgenerational response to these stimuli that manifests in the individual’s offspring. In dietary generalists, a parental effect could play an important role for offspring performance if the species experiences considerable variation in quality across host plants; positive parental effects may result from host matching between parents and offspring on high-quality host plants, whereas …

Editorial: Plant Responses To Abiotic Stress: Unraveling Complex Mechanisms Through Genomics And Physiology, Mizanur Rahman, Takashi Asaeda, Md Harun Rashid

School of Earth, Environmental, & Marine Sciences Faculty Publications

No abstract provided.

Christopher Nguyen V. Mary Johnson

2026 Decisions

USDC for the Eastern District of Pennsylvania

Quality Improvement Project The Impact Of The Interact “Stop And Watch Tool” In A Skilled Nursing Facility, Lorraine Hicks

Doctor of Nursing Practice Projects

Avoidable hospitalizations from skilled nursing facilities (SNF) contribute to increased healthcare costs, resident distress, and adverse health outcomes. Many readmissions result from delays in identifying and communicating early signs of resident deterioration. The purpose of this project was to implement an evidence-based intervention to recognize early changes in residents’ conditions, empower nursing staff to detect and promptly communicate concerns, and impact 30-day hospital readmission rates. Problems identified included delayed recognition of early changes in residents’ conditions, fragmented staff communication, and the absence of standardized reporting practices, which were associated with preventable hospital readmissions. A quasi-experimental pre-/post-intervention design guided by Jean …

Ecological Insights From Field And Laboratory Studies Of Akashiwo Sanguinea, Alexis L. Pasulka, Matthew J. Harke, Jaden Hansen, Ryan K. Walter, Eva Kokkino

Physics

Blooms of the dinoflagellate Akashiwo sanguinea occur in coastal ecosystems worldwide and can have significant ecological consequences. Along the central California coast, long-term oceanographic and harmful algal bloom observations indicate that A. sanguinea has exhibited seasonal blooms since approximately 2017, coinciding with negative upwelling anomalies and warm, stratified conditions characteristic of late summer and early fall. In laboratory experiments, three A. sanguinea strains isolated from different sites and/or environmental conditions along the central California coast exhibited variation in growth rates, temperature sensitivity, and transcriptional responses. Under the conditions tested in this study, one strain exhibiting higher maximum growth rates and …

Microglial Swell1 Deficiency Drives Male-Specific Seizure Vulnerability But Paradoxical Neuroprotection Through Impaired Phagocytosis, Abhijeet S Barath, Aastha Dheer, Laura Montier, Mekenzie M Peshoff, Emily Dale, Flavia Goche, Thanh Thanh Le Nguyen, Mastura Akter, Fangfang Qi, Dimitrios Kleidonas, Lauren Harris, Sarah A Jewanee, Anthony D Umpierre, Dale B Bosco, Koichiro Haruwaka, Rajan Sah, Long-Jun Wu, Rongzhuo Hua, Tejaswani Datla

The Brown Foundation: Institute of Molecular Medicine

The discovery of genes encoding the volume-regulated anion channel (VRAC) has enabled detailed exploration of its cell type-specific roles in the brain. LRRC8A (SWELL1) is the essential VRAC subunit. We observed seizure-induced, subunit-specific changes in microglial VRAC expression and investigated its function using conditional KO (cKO) of LRRC8A in microglia. SWELL1 cKO mice exhibited a male-specific increase in kainate-induced seizure severity, yet showed paradoxical neuroprotection against seizure-associated neuronal loss. Mechanistically, SWELL1 deletion led to a cell-autonomous reduction in microglial density and decreased release of VRAC-permeable neuroactive metabolites, including taurine, GABA, and glutamate in culture. Additionally, impaired phagocytic kinetics and reduced …

Integrating Spirituality In Management, Josep F. Mària Serrano S.J.

Journal of Management for Global Sustainability

No abstract provided.

Market Channel Preferences And Influencing Factors In The Traditional Rice Enterprise In Abra, Philippines, Kae Ann Marie P. Balingit

Journal of Management for Global Sustainability

This study examines the market channel preferences of traditional rice farmers and traders in Abra, Philippines, and identifies the socio-economic, institutional, and production factors influencing these choices. Using a mixed-methods approach, data were collected from 139 respondents through surveys and 52 qualitative interviews. Logistic regression and thematic analysis were employed to explain market behavior. Results show a strong preference for informal, direct-to-consumer channels, driven by immediate cash needs, low transaction costs, and institutional constraints. Production experience and farm scale increase the likelihood of participation in structured markets, while higher production frequency reduces it due to timing and market absorption limitations. …

Resúmenes, Iajbs Ateneo De Manila University

Journal of Management for Global Sustainability

No abstract provided.

Full Issue, Iajbs Ateneo De Manila University

Journal of Management for Global Sustainability

No abstract provided.

La Integración De La Espiritualidad En La Gestión, Josep. F. Mària Serrano S.J.

Journal of Management for Global Sustainability

No abstract provided.

[Excerpt From] A Nurse's Step-By-Step Guide To Writing A Dissertation Or Scholarly Project, Fourth Edition, Karen M. Roush

Sigma Publications: Book Excerpts

Packed with practical steps and tools, this updated fourth edition of A Nurse’s Step-by-Step Guide to Writing a Dissertation or Scholarly Project will help you plan, document, organize, and write your dissertation or scholarly project. Don’t go it alone; let author and fellow dissertation survivor Karen Roush help you get from square one to DONE.

Label-Flip Attack Detection Via Trust-Weighted Aggregation In Federated Learning For Underground Mine Security, Md Sazedur Rahman, Sanjay Madria, Samuel Frimpong

Computer Science Faculty Research & Creative Works

Underground mining operations are increasingly dependent on autonomous vehicles, robotic drilling systems, and intelligent inspection platforms operating in confined, GPS-denied tunnel environments. These systems rely on distributed perception models to interpret navigation cues, hazard warnings, and environmental signals in real time. While centralized deep learning can enhance model performance, transferring raw operational data across mining sites introduces serious confidentiality and security risks. Federated Learning (FL) offers a privacy-preserving alternative by enabling collaborative model training without sharing local datasets. However, deploying FL in underground mining introduces several critical challenges: (i) Training labels may be modified either maliciously by compromised clients or …

Dark-Matter-Deficient Twins: Fcc 224 And Fcc 240 As Possible Analogs Of Ngc 1052-Df2 And Df4, Maria Luísa Buzzo, Pieter Van Dokkum, Michael Hilker, Duncan A. Forbes, Aaron J. Romanowsky, Yimeng Tang

Faculty Research, Scholarly, and Creative Activity

The recent “bullet-dwarf” model proposes that high-velocity collisions between dwarf galaxies can produce stellar systems with overluminous globular clusters (GCs) and a deficiency of dark matter, as observed in the NGC 1052 group galaxies NGC 1052-DF2 and NGC 1052-DF4. We present a possible analog system in the outskirts of the Fornax cluster: the ultradiffuse galaxy FCC 224 and its close companion FCC 240. Using deep Very Large Telescope/MUSE integral field spectroscopy, we characterize their stellar populations, internal kinematics, and GC systems to test this formation scenario. Both galaxies exhibit low velocity dispersions. Interpreted with a standard mass estimator at the …

An Ai Perspective On Counseling Supervision, Emily A. Brinck, James L. Soldner, Hung Jen Kuo, Scott A. Sabella, Trenton J. Landon, Charles P. Bernacchio, Elizabeth A. Boland

Special Education and Rehabilitation Counseling Faculty Publications

The increased use of technology-assisted distance counseling practices is one result of COVID’s impact on behavioral health, including in counselor education and the delivery of supervision. First, technology-assisted distance supervision needed for “real time” communication grew. Furthermore, there is an emergence of artificial intelligence (AI) technologies that have the potential to contribute to aspects of supervision; however, current evidence remains emerging, context-dependent, and at times mixed, warranting cautious interpretation of their effectiveness. The article offers an overview of using AI in clinical supervision, examines the benefits and potential concerns of AI from different perspectives, and considers the significance of using …

Wangdu V. Kengmeni

All Decisions

In this civil action by a former landlord against former tenants for use and occupancy, the court reduced the judgment to account for the tenants' warranty of habitability counterclaim, finding that the basement of the single-family rental was uninhabitable for a significant period of time.

Vivid Realty Llc V. Jones

All Decisions

In this nonpayment proceeding involving a HUD-assisted unit, tenant moved pursuant to CPLR §408 for discovery of her tenant file and for an order to correct HPV violations at the premises. On discovery, the court held that tenant established ample need, citing the HUD Handbook Chapter 5 requirement that tenant files be available for tenant review; the court noted this right is not limited by CPLR §408's ample need standard, which is more readily established when a tenant must resort to a court motion to access her own file. All requested documents pertained directly to the central issue of rent …

Lorene Barksdale V. New American Funding Llc

2026 Decisions

USDC for the Western District of Pennsylvania

An Inf2-Dependent Actin-Mediated Step In Inositol 1,4,5-Trisphosphate Receptor Cluster Formation And Activity, Maite R. Zavala, Amrapali Ghosh, Suresh K. Joseph, Rajarshi Chakrabarti

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Intracellular calcium signaling plays a vital role in regulating various cellular processes including gene regulation, motility, metabolism, and cell death. Inositol 1,4,5-trisphosphate receptors (IP3Rs) on the endoplasmic reticulum (ER) are a major cation channel that regulates stimulus-induced calcium release from the ER. While several molecular players regulate the activity of IP3R, its regulation by actin filaments was uncharacterized. Here, we show that actin filaments polymerized by the specific actin nucleator INF2 facilitate agonist-induced IP3R activity. Our results demonstrate that INF2-mediated actin filaments regulate the formation and/or stability of IP3R clusters on the ER that have been previously shown to be …

The Road To Gerontocracy, Juan David Bohorquez Pacateque, Alonso Morales Sánchez Mejorada, Paul Alexander Villegas Muñoz

Journal of New Finance

The purpose of this article is to develop a reform proposal for current pension systems based on a robust political economy approach. The research is documentary, conducting critical analysis of texts and evidence collection from various pension schemes from a public choice perspective to elaborate a comparative institutional analysis. Pension schemes, being influenced by political processes, are susceptible to adopting institutions that are inefficient, so a politically and economically robust reform is proposed. In conclusion, taking into account that pension systems can be co-opted by the political process, it is not sufficient to propose financially sustainable schemes but also ones …

Enhancing Sleep Quality Through Sleep Hygiene Education Among Adults In A Faith-Based Community, Denielle Earle-Thompson

Doctor of Nursing Practice Projects

Background

Adults between 18 and 64 years of age require at least seven hours of sleep per night; however, many adults do not meet this recommendation, contributing to increased risks for chronic disease, impaired functioning, mood disturbances, and reduced quality of life. Poor sleep quality has been associated with weakened immunity, cardiovascular disease, diabetes, obesity, anxiety, depression, and decreased daytime performance. Obtaining adequate, good-quality sleep is essential for maintaining overall health and well-being. In faith-based communities, combining health education with spiritual support may provide a holistic approach that addresses both physical and emotional contributors to poor sleep.

Purpose

The purpose …

Numerical Study Of The Effect Of Embedded Radiation On Fluid Flow And Heat Transfer In A Porous Medium, Shaymaa M. Younus, Iman Al-Obaidi

Baghdad Science Journal

This takes a look at ambitions to investigate the two-dimensional flow pattern of fluids in a conductive medium constrained between two parallel horizontal plates under the influence of embedded radiation. The mathematical model is based entirely on the flow equations, including the continuity, momentum, energy, and diffusion equations. The machine is solved numerically the usage of the specific finite difference approach (ADE) to investigate the conduct of drift, temperature, and mass transfer below radiative outcomes. The study specializes in the impact of key dimensionless parameters, including the Reynolds number, Darcy number, Grashof number, Péclet number, radiation parameter, mixed radiation, and …

Digraph And Graph Of Regular Rings With Some Properties, Shahla Moayad Kaleel, Haitham Nashwan Mohammed, Ahmad Mohammed Alghamdi, Ahmed Mohammed Ali, Eman Sultan Almotairi

Baghdad Science Journal

During this century, a new research trend has emerged wherein algebraic concepts are combined with graph theory, such as zero divisors, clean rings, ideals, and regular rings. Continuing this trajectory, the regular ring graph has been studied in two forms: the undirected graph and the directed graph. The vertex set consists of all regular elements in the ring ℜ, denoted by ℜ(ℜ), where the undirected graph is denoted by Γ(ℜ(ℜ)) and the directed graph by Ψ(ℜ(ℜ)). This study focuses on the rings Z_n, where n = q, q², or 2q, and q is a prime number. In …

Intouch Week Of June 22, 2026, New York Medical College

InTouch

• Sixth Annual NYMC Golf Tournament Drives Support for Future Health Care Leaders
• Center for Disaster Medicine Receives NYS Funding
• Dean’s Faculty Awards Recognize Excellence in Teaching, Mentoring, and Service
• Football Associated with Nearly One in Five Brain Injuries in Youth Sports
• Touro College of Dental Medicine Hosts Its Ninth Annual Golf, Tennis and Mahjong Event
• Alumni Spotlight: Sumaita Mahmood, M.D./M.P.H. ’26, Receives National Public Health Award

Single Mothers: What Utahns Need To Know, Brie Sparks, Susan R. Madsen

Marketing and Strategy Faculty Publications

Single mothers represent a significant and growing share of families in Utah and across the United States, yet they face distinct structural, economic, and social challenges that impact both family well-being and broader community outcomes. While single mothers play a critical role as primary caregivers and contributors to the workforce, data show that they are disproportionately affected by poverty, barriers to education, employment instability, and mental health challenges. At the same time, research has found that when systems, policies, and communities effectively support parents raising children alone, outcomes improve for families as well as for the long-term strength of the …

Strategic Analysis Of The Robotic Surgery Market, Matthew Mavandi, Elif B. Dilden

Student Publications

Robotic-assisted surgery represents a rapidly growing segment of the US medical device market. This editorial applies Porter’s Five Forces, political, economic, social, and technological (PEST) analysis, and value, rarity, inimitability, and organization (VRIO) analysis, along with qualitative interpretation, to examine the competitive structure of the robotic surgery market. High development costs, extensive healthcare regulation, and limited technological supply have slowed competitive entry, but growing demand has intensified competitive pressure. The market appears to favor established firms because of high switching costs, existing long-term hospital relationships, and surgical familiarity with established robotic platforms. Existing firms may be positioned for continued growth …