Digital Commons Network^™

Family Size And Child Migration: Do Daughters Face Greater Trade-Offs Than Sons?, Christine Ho, Yutao Wang, Sharon Xuejing Zuo

Research Collection School Of Economics

We show that, conditional on family size, rural boys and girls are equally likely to migrate with parents in China. Nevertheless, daughters’ migration may still be compromised because they tend to have more siblings in societies with strong son preference, and larger families are more likely to leave all children behind. We find that a one unit increase in sibship size decreases the probability that a daughter migrates by 12.5 percentage points—with stronger effects when migration restrictions are more stringent—but has negligible effects on sons. The results suggest that gender-neutral migration constraints may generate gendered family size trade-offs.

(Trade) War And Peace: How To Impose International Trade Sanctions, Gustavo De Souza, Naiyuan Hu, Haishi Li, Yuan Mei

Research Collection School Of Economics

What is the most cost-efficient way to impose trade sanctions against Russia? We build a quantitative model of international trade with input–output connections. Sanctioning countries choose import tariffs to simultaneously maximize their income and minimize Russia's income, with different weights placed on these objectives. We find, first, that for countries with low willingness to pay for sanctions against Russia, the most cost-efficient sanction is an approximately 20% tariff on all Russian products. Second, if countries are willing to pay at least US$0.70 for each US$1 drop in Russian welfare, an embargo on Russia's mining and energy products is the most …

Impact Of Sars-Cov-2 (Covid-19) Infections On Mental Health Diagnoses In Youth With Chronic Illness, Molly Mcvoy, Rina Hung, Irina Bransteter, David W. Miller, Jeffrey A. Dusek, Martha Sajatovic

Faculty Scholarship

Objective: Stressors from the COVID-19 pandemic and limited availability of mental health care services have negatively impacted youth mental health in a significant way. In the first year of the pandemic, global prevalence of anxiety and depression increased by roughly 25% in pediatric populations. While the general trend is clear, this research aimed to explore the added mental health burden of acute COVID-19 on pediatric patients with chronic conditions and describe the differences in mental health outcomes between pediatric patients with 2 common chronic conditions (asthma and diabetes) to better understand specific factors that may increase susceptibility to mental health …

Beyond Machines: Exploring Human Identity In The Times Of Ai, Germán H. Alférez

Achieve

Secular conflicting worldviews constantly influence our students with assumptions regarding human life, reality, origins, deity, the universe, purpose, truth, values, meaning, and destiny. In this presentation, we will review the concept of worldview and discuss major worldviews with a special emphasis on transhumanism. We will study how, as Adventist educators, we can help our students develop a reliable Biblical worldview from which they can pursue their vocation, make decisions, and prepare for eternity.

Theoretical And Experimental Study Of Thermoradiative Cells For Space Power Generation, Andrew Schaefer

Theses

Reliable power production is always a core element when engineers design a space mission. Typically, III-V solar arrays are used due to their high efficiency, radiation tolerance, and overall reliability. One downside of photovoltaics involves the need for incident light from the Sun. There are many places in the solar system and beyond that do not have access to sustained, high concentration solar radiation. As missions fly farther from the Sun, the available light power decreases with the inverse square of the distance. This means that missions past Jupiter are only receiving one tenth the solar power compared to Earth. …

The Performance Relationship Between The Eq-5d-5l Composite "Anxiety/Depression" Dimension And Anxiety And Depression Symptoms In A Large, General Population Sample, Emily Stella Scott, Erica I. Lubetkin, Mathieu F. Janssen, John N. Yfantopolous, Gouke J. Bonsel, Juanita A. Haagsma

Publications and Research

Purpose

This cross-sectional study aims to understand the relationship between responses on the Anxiety/Depression (A/D) dimension of the EQ-5D-5L and symptoms of anxiety and depression on the GAD-7 and PHQ-9 instruments. In doing so, we investigate the comparative performance of the dimension between diagnostic groups (i.e. anxiety (GAD-7); depression (PHQ-9); anxiety & depression versus none). We additionally investigate the discriminatory performance between sub-populations based on gender, age, education and self-reported chronic conditions.

Methods

19,902 general population participants completed a health survey in May/June 2020, from five European countries and the United States. Performance of A/D was calculated using the Area …

Effects Of Titanium Particulates On Concrete Compressive Strength, Ryan Christopher Brunello

Construction Management

Titanium has the potential to increase the compressive strength of concrete. This experiment investigates the impact of titanium admixture on concrete compressive strength, using three different forms of titanium: shavings, flakes, and powder. This experiment goes further, evaluating the effects of varying proportions of titanium admixture, ranging from 1% - 5% by the weight of cement, resulting in 15 different concrete test cylinders and one additional cylinder as the control variable with no titanium admixture. This experiment aims to identify the optimal recipe for concrete mix with titanium admixture which can provide valuable insight to the industry as to how …

Response Of ¹¹B Enriched Zrb2 Ultra-High Temperature Ceramic To Neutron Irradiation At Elevated Temperatures, Yan Ru Lin, Takaaki Koyanagi, David J. Sprouster, Christian M. Petrie, William Fahrenholtz, Greg Hilmas, Yutai Katoh

Materials Science and Engineering Faculty Research & Creative Works

ZrB₂, an ultra-high temperature ceramic (UHTC) is being considered for use in fusion reactor first-wall structures, yet its response to irradiation remains poorly understood. This study employed scanning/transmission electron microscopy (S/TEM), synchrotron X-ray diffraction (XRD), finite element calculations, and thermal property measurements to thoroughly investigate the neutron-irradiation effects on ¹¹B-enriched ZrB₂. Neutron irradiations were conducted at 220 °C and 620 °C, with a neutron fluence of 2.2 x 1025 neutron/m2 (energy > 0.1 MeV), resulting in 3.9 dpa and 4200 appm He. The study revealed the unusual prevalence of prism loops and a > c anisotropic lattice …

Study Of The Structure Of Zn And Na Borophosphate Glasses Using X-Ray And Neutron Scattering Techniques, Uwe Hoppe, Parker T. Freudenberger, Richard K. Brow, Jozef Bednarčik, Alex C. Hannon

Materials Science and Engineering Faculty Research & Creative Works

The atomic structures of Zn and Na borophosphate glasses were studied using X-ray and neutron scattering techniques. Peaks assigned to the B−O, P−O, and O−O distances confirm that only BO₄ units co-exist with the PO₄ tetrahedra. The Zn−O and Na−O coordination numbers are found to be a little larger than four. The narrowest peaks of the Zn−O first-neighbor distances exist for the glasses along a line connecting the Zn (PO₃)₂ and BPO₄ compositions (50 mol% P₂O₅), which is explained by networks of ZnO₄, BO₄, and PO …

Value Of Electrical Heavy Civil Machinery In The American Construction Industry, Kaston Wong

Construction Management

Every day the construction industry is releasing an unhealthy amount of greenhouse gases into the atmosphere. The consequences may seem trivial at first because the planet is slowly deteriorating, and it is not easily discernable on a day-to-day basis; however, similar to constantly taking care of one’s home, one must take care of the planet. On the other hand, the difference between degradation of a home and planet is that the pollution released into the world is irreversible; therefore, we need to be even more conscientious of the environment. As the construction industry continues to grow, the need for heavy …

The 10 Commandments Of Endo-Bentall Repair, Mehrdad Ghoreishi

All Publications

No abstract available

Exploit The Potential Clinical Benefit Of Using Proton Arc Therapy For Esophageal Cancer, Peilin Liu, Xiaoda Cong, Raymond Dalfsen, Martin Soukup, James E. Dolan, Shupeng Chen, Craig Stevens, Rohan Deroniyagala, Xiaoqiang Li, Xuanfeng Ding

Conference Presentation Abstracts

No abstract provided.

Quantitative Evaluation Of Gantry Rotation Perturbation Effects On Spot-Scanning Arc Therapy (Sparc), Peilin Liu, Lewei Zhao, Gang Liu, Xiaoda Cong, Xiaoqiang Li, Xuanfeng Ding

Conference Presentation Abstracts

Purpose: To quantitatively assess the impact of random gantry rotation perturbations on spot-scanning arc (SPArc) therapy.

Methods:

To simulate random gantry rotation perturbations, the initial gantry angle of SPArc treatment plans was modified using an in-house script. Four cases from different disease sites include brain, lung, liver and prostate were selected to evaluate. Original SPArc plans (SPArc_org) were developed through iterative processes, including control point re-sampling, redistribution of control points & energy layers, energy layer filtration, and re-sampling. Considering potential limitations, rotation perturbations of 1mm and 2mm were applied to al SPArc_org plans to generate perturbed SPArc …

A Multifactorial Study Of Factors Influencing Self-Health Behaviors In Dementia, Elizabeth Malkin

Dissertations

The global increase in dementia cases presents a significant public health challenge, particularly given the absence of a cure and the rising healthcare burden on individuals and society. This study aims to examine the influence of knowledge, beliefs, and motivation on self-health behaviors to mitigate the risk of dementia among individuals residing in the United States. With the use of an online survey, the study utilized the U.S. normed MCLHB-DRR scale and supplemental questions about knowledge of risk factors and degree of closeness to family members with dementia to determine whether (1) more closely related relatives (first-degree relatives) and those …

Infertility’S Impact On Couples’ Functioning, Elizabeth Sanders

Dissertations

Historically, infertility has been a taboo topic of discussion and is often avoided in conversation because of the stigmatization of the diagnosis. According to the World Health Organization (2022), infertility affects 186 million individuals globally. However, there seems to be a gap in the research as it pertains to the psychological well-being and treatment of men and women diagnosed with this condition. While it has become less of a feared topic, it still is not discussed or researched enough, thus further exacerbating the gap in research on mental health and treatment options. The following dissertation completed a critical review of …

Transformational Leadership Teams And Implementing Multi-Tiered Systems Of Support [Mtss] In The Context Of An Urban All-Male Catholic High School: Bridging The Gap To Academic Identity And Student Efficacy, Markeise R. Russell

Dissertations

This study explored the implementation of Multi-Tiered Systems of Support (MTSS) at Garfield High School, an urban all-male Catholic high school in Chicago. The study aimed to understand the perceptions and experiences of school leaders and stakeholders in facilitating MTSS implementation. Using Tony Wagner's 4C Framework of Context, Culture, Conditions, and Competencies, the researcher assessed the current state ("As-Is") of the MTSS and envisioned the desired future state ("To-Be"). A qualitative research design was employed, involving interviews, focus groups, and document analysis to gather in-depth insights from administrators, teachers, and support staff. The purpose of the study was to identify …

Evaluation Of Educator Outcomes Of Teaching Social-Emotional Learning, Mindfulness, And Life Skills, Gary Mccarthy

Dissertations

There have been many studies documenting the benefits of social – emotional (SEL) instruction for students, but fewer on how teaching SEL curriculums may alleviate teacher burnout. I used a mixed methods research design to investigate the impact of teaching social-emotional learning, mindfulness, and life skills through The Leader in Me (LiM), a K-12 whole-school improvement model based on The 7 Habits of Highly Effective People on educators. The outcomes of surveys and interviews indicated that most educators in my study reported personal and professional benefits from teaching and modeling the program. My recommendations include further implementation of SEL, Mindfulness, …

Tev Analysis Of A Source-Rich Region With The Hawc Observatory: Is Hess J1809-193 A Potential Hadronic Pevatron?, A. Albert, R. Alfaro, C. Alvarez, J. C. Arteaga-Velázquez, D. Avila Rojas, R. Babu, E. Belmont-Moreno, A. Bernal, M. Breuhaus, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, J. Cotzomi, E. De La Fuente, D. Depaoli, N. Di Lalla, R. Diaz Hernandez, B. L. Dingus, M. A. Duvernois, C. Espinova, K. L. Fan, K. Fang, B. Fick, N. Fraija, J. A. Garcia-Gonzalez, F. Garfias, A. Gonzalez Munoz, M. M. Gonzalez, J. A. Goodman, S. Groetsch, J. P. Harding, S. Hernandez-Cadena, I. Herzog, D. Huang, F. Hueyotl-Zahuantitla, P. Huntemeyer, A. Iriarte, V. Joshi, S. Kaufmann, A. Lara, J. Lee, H. Leon Vargas, A. L. Longinotti, G. Luis-Raya, K. Malone, J. Martines-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Montes, J. A. Morales-Soto, E. Moreno, M. Mostafa, L. Nellen, M. Newbold, M. U. Nisa, R. Noriega-Papaqui, M. Osorio, Y. Perez Araujo, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, E. Ruiz-Velasco, H. Salazar, A. Sandoval, M. Schneider, J. Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Urena-Mena, E. Varela, Xiaojie Wang, I. J. Watson, E. Willox, S. Yun-Carcamo, H. Zhou

Physics Faculty Research & Creative Works

HESS J1809-193 is an unidentified TeV source, first detected by the High Energy Stereoscopic System (H.E.S.S.) collaboration. The emission originates in a source-rich region that includes several supernova remnants (SNRs) and pulsars including SNR G11.1+0.1, SNR G11.0-0.0, and the young radio pulsar PSR J1809-1917. Originally classified as a pulsar wind nebula candidate, recent studies show the peak of the TeV region overlapping with a system of molecular clouds. This resulted in the revision of the original leptonic scenario to look for alternate hadronic scenarios. Marked as a potential PeVatron candidate, this region has been studied extensively by H.E.S.S. due to …

Performance Of The Hawc Observatory And Tev Gamma-Ray Measurements Of The Crab Nebula With Improved Extensive Air Shower Reconstruction Algorithms, A. Albert, R. Alfaro, C. Alvarez, A. Andrés, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, A. Bernal, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, F. Carreón, S. Casanova, U. Cotti, J. Cotzomi, S. Coutiño De León, E. De La Fuente, C. De Leon, D. Depaoli, N. Di Lalla, R. Diaz Hernandez, B. L. Dingus, M. A. Duvernois, K. Engel, T. Ergin, C. Espinoza, K. L. Fan, K. Fang, N. Fraija, S. Fraija, J. A. Garcia-Gonzalez, F. Garfias, H. Goksu, M. M. Gonzalez, J. A. Goodman, S. Groetsch, J. P. Harding, S. Hernandez-Cadena, I. Herzog, J. Hinton, D. Huang, F. Hueyotl-Zahuantitla, P. Huntemeyer, A. Iriarte, S. Kaufmann, A. Lara, J. Lee, H. Leon Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, J. Martinez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Montes, E. Moreno, M. Mostafa, L. Nellen, M. U. Nisa, R. Noriega-Papaqui, L. Olivera-Nieto, N. Omodei, M. Osorio-Archila, Y. Perez Araujo, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, A. Sandoval, M. Schneider, G. Schwefer, J. Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Urena-Mena, E. Varela, Xiaojie Wang, I. J. Watson, K. Whitaker, E. Willox, H. Wu, S. Yu, S. Yun-Carcamo, H. Zhou

Physics Faculty Research & Creative Works

The High-Altitude Water Cherenkov (HAWC) Gamma-Ray Observatory, located on the side of the Sierra Negra volcano in Mexico, has been fully operational since 2015. The HAWC collaboration has recently significantly improved their extensive air shower reconstruction algorithms, which has notably advanced the observatory performance. The energy resolution for primary gamma rays with energies below 1 TeV was improved by including a noise-suppression algorithm. Corrections have also been made to systematic errors in direction fitting related to the detector and shower plane inclinations, O ( 0 .° 1 ) biases in highly inclined showers, and enhancements to the core reconstruction. The …

Observation Of The Galactic Center Pevatron Beyond 100 Tev With Hawc, A. Albert, R. Alfaro, C. Alvarez, A. Andrés, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, A. Bernal, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, U. Cotti, J. Cotzomi, S. Coutiño De León, E. De La Fuente, C. De Leon, D. Depaoli, N. Di Lalla, R. Diaz Hernandez, B. L. Dingus, M. A. Duvernois, J. C. Diaz-Velez, K. Engel, T. Ergin, C. Espinoza, K. L. Fan, K. Fang, N. Fraija, S. Fraija, J. A. Garcia-Gonzalez, F. Garfias, H. Goksu, M. M. Gonzalez, J. A. Goodman, S. Groetsch, J. P. Harding, S. Hernandez-Cadena, I. Herzog, J. Hinton, D. Huang, F. Hueyotl-Zahuantitla, T. B. Humensky, P. Huntemeyer, A. Iriarte, S. Kaufmann, D. Kieda, A. Lara, W. H. Lee, J. Lee, H. Leon Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, O. Martinez, J. Martinez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Montes, J. A. Morales-Soto, E. Moreno, M. Mostafa, M. Najafi, L. Nellen, M. Newbold, M. U. Nisa, R. Noriega-Papaqui, L. Olivera-Nieto, N. Omodei, M. Osorio-Archila, Y. Perez Araujo, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, A. Sandoval, M. Schneider, G. Schwefer, J. Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Urena-Mena, E. Valera, Xiaojie Wang, Z. Wang, I. J. Watson, E. Willox, H. Wu, S. Yu, S. Yun-Carcamo, H. Zhou

Physics Faculty Research & Creative Works

We report an observation of ultrahigh-energy (UHE) gamma rays from the Galactic center (GC) region, using 7 yr of data collected by the High-Altitude Water Cherenkov (HAWC) Observatory. The HAWC data are best described as a point-like source (HAWC J1746-2856) with a power-law spectrum ( d N / d E = ϕ E / 26 TeV γ ), where γ = −2.88 ± 0.15stat − 0.1sys and ϕ = 1.5 x 10⁻¹⁵ (TeV cm² s)⁻¹ ± 0.3 stat − 0.13 sys + 0.08 sys extending from 6 to 114 TeV. We find no evidence of a spectral …

Cover Crop And Wheel-Track Effects On Soil Properties Under Cotton Production In Eastern Arkansas, Shelby G. Lebeau, Kristofor R. Brye, Michael Daniels, Lisa S. Wood

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Repetitive use of heavy farm machinery in cultivated agriculture may cause soil compaction that can adversely affect soil-health-related properties. Cover crops (CC) are well-documented to alleviate problems associated with compaction and improve overall soil health in time. The objective of this field study was to evaluate the cumulative effects of CC treatment (i.e., with ≥ 6 years cereal rye [Secale cereale L.] CC and ≥ 4 years with no cover crop [NCC]) and sample/measurement placement (i.e., in the bed [B] and in the wheel-track [WT] and no-wheel-track [NWT] furrow) on near-surface soil physical-, chemical-, and infiltration-related properties in an …

Against: Adoption Of New Technologies In Radiation Oncology Must Be Evidence-Based, Xuanfeng Ding

Conference Presentation Abstracts

No abstract provided.

Behind Armor Blunt Trauma: Liver Injuries Using A Live Animal Model, Narayan Yoganandan, Alok Shah, Brian D. Stemper, Lewis Somber, Valeta Carol Chancey, Joseph Mcentire

Biomedical Engineering Faculty Research and Publications

Introduction

While the 44-mm clay penetration criterion was developed in the 1970s for soft body armor applications, and the researchers acknowledged the need to conduct additional tests, the same behind the armor blunt trauma displacement limit is used for both soft and hard body armor evaluations and design considerations. Because the human thoraco-abdominal contents are heterogeneous, have different skeletal coverage, and have different functional requirements, the same level of penetration limit does not imply the same level of protection. It is important to determine the regional responses of different thoraco-abdominal organs to better describe human tolerance and improve the current …

The Shriners Children's Standard Gait Model (Scgm), Karen M. Kruger, Patrick Fischer, Sam Augsburger, Jing Feng, Jean-Francois Girouard, Daniel L. Gregory, Logan Johnson, Bruce A. Macwilliams, Mark L. Mcmulkin, Bradley Nelson, Spencer Warshauer, Prabhav Saraswat, Ross S. Chafetz

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Ataxia Telangiectasia And Rad3-Related (Atr) Inhibitor Camonsertib Dose Optimization In Patients With Biomarker-Selected Advanced Solid Tumors (Tresr Study), Elisa Fontana, Ezra Rosen, Elizabeth K Lee, Martin Højgaard, Niharika B Mettu, Stephanie Lheureux, Benedito A Carneiro, Gregory M Cote, Louise Carter, Ruth Plummer, Devalingam Mahalingam, Adrian J Fretland, Joseph D Schonhoft, Ian M Silverman, Marisa Wainszelbaum, Yi Xu, Danielle Ulanet, Maria Koehler, Timothy A Yap

Faculty, Staff and Student Publications

BACKGROUND: Camonsertib is a selective oral inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase with demonstrated efficacy in tumors with DNA damage response gene deficiencies. On-target anemia is the main drug-related toxicity typically manifesting after the period of dose-limiting toxicity evaluation. Thus, dose and schedule optimization requires extended follow-up to assess prolonged treatment effects.

METHODS: Long-term safety, tolerability, and antitumor efficacy of 3 camonsertib monotherapy dosing regimens were assessed in the TRESR study dose-optimization phase: 160 mg once daily (QD) 3 days on, 4 days off (160 3/4; the preliminary recommended Phase II dose [RP2D]) and two step-down groups of …

Identification Of Hypoxia-Alcamhigh Macrophage- Exhausted T Cell Axis In Tumor Microenvironment Remodeling For Immunotherapy Resistance, Zhenzhen Xun, Huanran Zhou, Mingyi Shen, Yao Liu, Chengcao Sun, Yanhua Du, Zhou Jiang, Liuqing Yang, Qing Zhang, Chunru Lin, Qingsong Hu, Youqiong Ye, Leng Han

Faculty, Staff and Student Publications

Although hypoxia is known to be associated with immune resistance, the adaptability to hypoxia by different cell populations in the tumor microenvironment and the underlying mechanisms remain elusive. This knowledge gap has hindered the development of therapeutic strategies to overcome tumor immune resistance induced by hypoxia. Here, bulk, single-cell, and spatial transcriptomics are integrated to characterize hypoxia associated with immune escape during carcinogenesis and reveal a hypoxia-based intercellular communication hub consisting of malignant cells, ALCAM

Ensemble Pretrained Language Models To Extract Biomedical Knowledge From Literature, Zhao Li, Qiang Wei, Liang-Chin Huang, Jianfu Li, Yan Hu, Yao-Shun Chuang, Jianping He, Avisha Das, Vipina Kuttichi Keloth, Yuntao Yang, Chiamaka S Diala, Kirk E Roberts, Cui Tao, Xiaoqian Jiang, W Jim Zheng, Hua Xu

Faculty, Staff and Student Publications

OBJECTIVES: The rapid expansion of biomedical literature necessitates automated techniques to discern relationships between biomedical concepts from extensive free text. Such techniques facilitate the development of detailed knowledge bases and highlight research deficiencies. The LitCoin Natural Language Processing (NLP) challenge, organized by the National Center for Advancing Translational Science, aims to evaluate such potential and provides a manually annotated corpus for methodology development and benchmarking.

MATERIALS AND METHODS: For the named entity recognition (NER) task, we utilized ensemble learning to merge predictions from three domain-specific models, namely BioBERT, PubMedBERT, and BioM-ELECTRA, devised a rule-driven detection method for cell line and …

Improving Large Language Models For Clinical Named Entity Recognition Via Prompt Engineering, Yan Hu, Qingyu Chen, Jingcheng Du, Xueqing Peng, Vipina Kuttichi Keloth, Xu Zuo, Yujia Zhou, Zehan Li, Xiaoqian Jiang, Zhiyong Lu, Kirk Roberts, Hua Xu

Faculty, Staff and Student Publications

IMPORTANCE: The study highlights the potential of large language models, specifically GPT-3.5 and GPT-4, in processing complex clinical data and extracting meaningful information with minimal training data. By developing and refining prompt-based strategies, we can significantly enhance the models' performance, making them viable tools for clinical NER tasks and possibly reducing the reliance on extensive annotated datasets.

OBJECTIVES: This study quantifies the capabilities of GPT-3.5 and GPT-4 for clinical named entity recognition (NER) tasks and proposes task-specific prompts to improve their performance.

MATERIALS AND METHODS: We evaluated these models on 2 clinical NER tasks: (1) to extract medical problems, treatments, …

Target Engagement And Immunogenicity Of An Active Immunotherapeutic Targeting Pathological Α-Synuclein: A Phase 1 Placebo-Controlled Trial, Pepijn Eijsvogel, Pinaki Misra, Luis Concha-Marambio, Justin D Boyd, Shuang Ding, Lauren Fedor, Yueh-Ting Hsieh, Yu Shuang Sun, Madeline M Vroom, Carly M Farris, Yihua Ma, Marieke L De Kam, Igor Radanovic, Maurits F J M Vissers, Dario Mirski, Ghazal Shareghi, Mohammad Shahnawaz, Wolfgang Singer, Philip Kremer, Geert Jan Groeneveld, Hui Jing Yu, Jean-Cosme Dodart

Faculty, Staff and Student Publications

Investigational therapeutics that target toxic species of α-synuclein (αSyn) aim to slow down or halt disease progression in patients with Parkinson's disease (PD). Here this 44-week, randomized, placebo-controlled, double-blind, single-center phase 1 study investigated safety, tolerability and immunogenicity of UB-312, an active immunotherapeutic targeting pathological αSyn, in patients with PD. The primary outcome measures were adverse event frequency and change in anti-αSyn antibody titers in blood and cerebrospinal fluid (CSF). Exploratory outcomes were changes in clinical scales and biomarker-based target engagement as measured by seed amplification assays. Twenty patients were randomized 7:3 (UB-312:placebo) into 300/100/100 μg or 300/300/300 μg (weeks …

Mechanistic Insights Into Metabolic Function Of Dynamin-Related Protein 1, Xin Li, Katherine Pham, Jazmin Ysaguirre, Iqbal Mahmud, Lin Tan, Bo Wei, Long J Shao, Maryam Elizondo, Rabie Habib, Fathima Elizondo, Hiromi Sesaki, Philip L Lorenzi, Kai Sun

Faculty, Staff and Student Publications

Dynamin-related protein 1 (DRP1) plays crucial roles in mitochondrial and peroxisome fission. However, the mechanisms underlying the functional regulation of DRP1 in adipose tissue during obesity remain unclear. To elucidate the metabolic and pathological significance of diminished DRP1 in obese adipose tissue, we utilized adipose tissue-specific DRP1 KO mice challenged with a high-fat diet. We observed significant metabolic dysregulations in the KO mice. Mechanistically, DRP1 exerts multifaceted functions in mitochondrial dynamics and endoplasmic reticulum (ER)-lipid droplet crosstalk in normal mice. Loss of function of DRP1 resulted in abnormally giant mitochondrial shapes, distorted mitochondrial membrane structure, and disrupted cristae architecture. Meanwhile, …