Digital Commons Network^™

Efficacy And Tolerability Of Brivaracetam In People With Intellectual Disability Compared To Those Without Intellectual Disability, Jon Allard, William Henley, Adrian Sellers, Emma O'Shaughnessy, Oliver Thomson, Brendan Mclean, Mary Parrett, Sanjeev Rajakulendran, Lance Watkins, Melissa Maguire, Shan Ellawela, Phil Tittensor, Arjune Sen, Rajiv Mohanraj, Manny Bagary, Sunil Ram, Allan Brown, Rohit Shankar

Peninsula Medical School

Introduction: In England, nearly a quarter of people with intellectual disability (PwID) have epilepsy. Though 70 % of PwID have pharmaco-resistant seizures only 10 % are prescribed anti-seizure medication (ASMs) licenced for pharmaco-resistance. Brivaracetam (BRV) licenced in 2016 has had nine post-marketing studies involving PwID. These studies are limited either by lack of controls or not looking at outcomes based on differing levels of ID severity. This study looks at evidence comparing effectiveness and side-effects in PwID to those without ID prescribed Brivaracetam (BRV). Methods: Pooled case note data for patients prescribed BRV (2016–2022) at 12 UK NHS Trusts were …

Detecting Anomalies In Blockchain Transactions Using Machine Learning Classifiers And Explainability Analysis, Mohammad Hasan, Mohammad Shahriar Rahman, Helge Janicke, Iqbal H. Sarker

Research outputs 2022 to 2026

As the use of blockchain for digital payments continues to rise, it becomes susceptible to various malicious attacks. Successfully detecting anomalies within blockchain transactions is essential for bolstering trust in digital payments. However, the task of anomaly detection in blockchain transaction data is challenging due to the infrequent occurrence of illicit transactions. Although several studies have been conducted in the field, a limitation persists: the lack of explanations for the model's predictions. This study seeks to overcome this limitation by integrating explainable artificial intelligence (XAI) techniques and anomaly rules into tree-based ensemble classifiers for detecting anomalous Bitcoin transactions. The shapley …

Graphene Oxide Decorated With Nickel Cobaltite Nanoparticles As An Adsorbent For Cationic Methyl Green Dye: Kinetic, Isotherm, And Thermodynamic Studies, Maryam Abdulsatar Abduljabar, Sundus Hadi Merza

Baghdad Science Journal

In this study, graphene oxide (GO) flakes were embellished with NiCo2O4 ‎‎(NC) nanoparticles by in situ deposition, and the produced composite (NC: ‎GO) was utilized as an adsorbent to remove methyl green dye (MG) from aqueous ‎solutions. The successful coating of graphene oxide with nickel cobaltite ‎nanoparticles (NC) was verified using FT-IR, SEM and X-ray diffraction (XRD) studies. ‎The crystalline particle sizes of NC nanoparticles and NC nanoparticles decorated ‎GO were 10.53 nm and 9.30 nm respectively. The impact of several experimental ‎factors, including time of contact, the dosage of adsorbent, and temperature were ‎investigated. The optimal contact time and …

Single Nucleotide Polymorphism (Snp) Rs2229569 With L Selectin Gene Expression In Iraqi Female During In Vitro Fertilization Program., Raghad Hameed Rashid, Asmaa M. Salih Almohaidi, Alia Hussain Ali

Baghdad Science Journal

Infertility is recognized as one of the leading reproductive health problems in various regions of the world. In vitro fertilization (IVF) is one of the most effective treatments for infertility. In the current research, the role of the selectin -L (SELL) gene, especially the rs2229569 polymorphism, has been determined in terms of implantation and expression level. This work involved 67 females who underwent an in vitro fertilization cycle, divided into two major groups: the implantation failure female group and the implantation success female group. Blood samples were collected from the females. After DNA extraction from blood sample then amplification by …

Investigation The Effect Of Thermal Agent On Physical Properties Of Pvc-Pva Blended, Zainab J. Neamah, Shatha H. Mahdi, Kareem A. Jasim

Baghdad Science Journal

In this study, the optical characteristics of polyvinyl chloride(PVC), polyvinyl alcohol (PVA) and binary PVA - PVC blend films at various concentrations PVA75% + PVC25%, PVA50% + PVC50%, and PVA25% + PVC 75% are examined in relation to temperature variations 25, 120 and 140 °C for 1 hour. The binary blend films of polyvinyl chloride and polyvinyl alcohol were produced using casting techniques. UV-visible spectroscopy used to determine the optical properties of the films in the wavelength range (200-900) nm, such as transmittance, absorbance, absorption coefficient and energy gap as well as the impact of temperature on these parameters, were …

Examining The Most Important Risk Factors For Predicting Youth Persistent And Distressing Psychotic-Like Experiences, Nicole R Karcher, Aristeidis Sotiras, Tara A Niendam, Elaine F Walker, Joshua J Jackson, Deanna M Barch

2020-Current year OA Pubs

BACKGROUND: Persistence and distress distinguish more clinically significant psychotic-like experiences (PLEs) from those that are less likely to be associated with impairment and/or need for care. Identifying risk factors that identify clinically relevant PLEs early in development is important for improving our understanding of the etiopathogenesis of these experiences. Machine learning analyses were used to examine the most important baseline factors distinguishing persistent distressing PLEs.

METHODS: Using Adolescent Brain Cognitive Development (ABCD) Study data on PLEs from 3 time points (ages 9-13 years), we created the following groups: individuals with persistent distressing PLEs (n = 305), individuals with transient distressing …

Reporte Border Fellows 2023, Márgara De León Cevallos, Aida Renee Amador, Javier Neftali Jiménez Quintana, Carla Ulloa Vázquez, Meritxell Calderón-Vargas, Carlos Foo-Kong, Psyché Calderón, Rebeca Cázarez Adame

Kroc IPJ Research and Resources

El propósito de este informe es proporcionar una descripción general de cada uno de los proyectos de los becarios y ubicarlos dentro del contexto más amplio de la región fronteriza Tijuana-San Diego.

Frontostriatal Salience Network Expansion In Individuals In Depression, Charles J Lynch, Evan M Gordon, Et Al.

2020-Current year OA Pubs

Decades of neuroimaging studies have shown modest differences in brain structure and connectivity in depression, hindering mechanistic insights or the identification of risk factors for disease onset

Structure Of A Truncated Human Glcnac-1-Phosphotransferase Variant Reveals The Basis For Its Hyperactivity, Hua Li, Balraj Doray, Benjamin C Jennings, Wang-Sik Lee, Lin Liu, Stuart Kornfeld, Huilin Li

2020-Current year OA Pubs

Mutations that cause loss of function of GlcNAc-1-phosphotransferase (PTase) lead to the lysosomal storage disorder mucolipidosis II. PTase is the key enzyme of the mannose 6-phosphate (M6P) targeting system that is responsible for tagging lysosomal hydrolases with the M6P moiety for their delivery to the lysosome. We had previously generated a truncated hyperactive form of PTase termed S1S3 which was shown to notably increase the phosphorylation level of secreted lysosomal enzymes and enhance their uptake by cells. Here, we report the 3.4 Å cryo-EM structure of soluble S1S3 lacking both transmembrane domains and cytosolic tails. The structure reveals a high …

Elemental Content And Safety Evaluation Of Wild-Harvested Australian Abalone (Haliotis Spp.) Viscera: Addressing Safety Concerns In Food Waste Upcycling, Wing H. Chung, Liezhou Zhong, Ryu Takechi, Ranil Coorey, Janet Howieson

Research outputs 2022 to 2026

Abalone viscera has been shown to be a valuable human nutraceutical, yet the food safety considerations of consuming whole abalone viscera have been largely overlooked. Hence, this research was conducted to investigate and evaluate elemental compositions and safety of it. The elemental data was compared to international food safety regulations and evaluated using the USEPA hazard index (HI) equation and HI-derived estimated upper limit (EDUL) equation, which EDUL allows comparison of novel foods with a large variety of similar existing products. To further demonstrate that food safety of upcycled food could be improved with simple processing, a risk mitigation trial …

Extracorporeal Membrane Oxygenation Support In Adult Patients With Calcium Channel Blocker Toxicity - An Elso Registry Analysis, Rakeshkumar Subramanian, Hariom Joshi, Amelia Roebuck, Tanvi Borse, Michelle Drouin

Hospital Medicine

Background: Calcium channel blocker (CCB) toxicity presents a significant mortality risk, highlighting the need for effective treatment strategies such as ECMO. This study analyzes ELSO registry data to determine the mortality rate in adults treated with ECMO for CCB toxicity and identifies clinical predictors of mortality.

Methods: A retrospective analysis of the ELSO registry from January 2016 to April 2023 was conducted, focusing on adults with CCB toxicity who received ECMO. Data collected included patient demographics, ECMO details, pre-ECMO clinical indicators, and in-hospital mortality. The analysis employed descriptive statistics to profile the patient population, with independent t-tests and chi-square tests …

Decoded Vision: Land, Bodies, And Ai In Syracuse -- Event Information, Lender Center For Social Justice

The Lender Center for Social Justice

A brief description of the “DeCoded Vision: Land, Bodies, and AI in Syracuse” conference event.

Nasogastric Tube Insertion Aid, Lauren S. Ark, Angela D. Biezins, Zachary B. Crum, Claire E. Nodine, Morgan N. Pope, Natsumi L. Shudo

Biomedical Engineering

The Nasogastric Tube Insertion Aid project, developed under the sponsorship of the BiCEP Program at California Polytechnic State University, aims to enhance the accuracy and efficiency of nasogastric (NG) tube placement. This initiative was inspired by challenges observed during the BiCEP summer program, where difficulties in NG tube insertions led to multiple attempts, increased patient discomfort, and serious medical risks, including lung punctures and brain trauma. The project's goal was to design an insertion aid that improves placement accuracy while being cost-effective and user-friendly for medical professionals. The device features an external tensioning mechanism that allows controlled deflection of the …

Precision Measurement Of The Absolute Energy Of The 2s3s 1S0 State In Neutral 9Be, K. J. Ahrendsen, T. Karani, W. D. Williams

Physics: Faculty Publications

We report on the absolute energy of the 2⁢��⁢3⁢��⁢1⁢��0 state in neutral 9Be. In doing so, we measure the transition frequencies of the 2⁢��2⁢1⁢��0→ 2⁢��⁢2⁢��⁢1⁢��∘1 and 2⁢��⁢2⁢��⁢1⁢��∘1→ 2⁢��⁢3⁢��⁢1⁢��0 transitions, also determining the absolute energy of the 2⁢��⁢2⁢��⁢1⁢��∘1 state. The results are obtained from a home-built hollow cathode discharge lamp using saturated absorption spectroscopy with laser frequencies referenced to a frequency comb. The transition frequencies are determined to be 1276080080⁢(50) and 363105650⁢(130) MHz for the 2⁢��2⁢1⁢��0→ 2⁢��⁢2⁢��⁢1⁢��∘1 and 2⁢��⁢2⁢��⁢1⁢��∘1→ 2⁢��⁢3⁢��⁢1⁢��0 transitions, respectively. The absolute energies are determined to be 42565.4498⁢(17) and 54677.350⁢(5) cm−1 for the 2⁢��⁢2⁢��⁢1⁢��∘1 and 2⁢��⁢3⁢��⁢1⁢��0 states, respectively. The …

Legal Hurdles And Pathways: The Evolution (Progress?) Of Climate Change Adjudication In Canada, Camille Cameron, Riley Weyman, Claire Nicholson

Dalhousie Law Journal

Citizens, civil society, and environmental justice organizations are increasingly turning to courts to find solutions to climate change challenges. As of November 2022, the number of climate change litigation cases throughout the world was at least 2.5 times higher than in 2017. A dominant wave of this litigation is one in which claimants assert that governments’ failures to take appropriate mitigation and adaptation measures violate claimants’ rights. We analyze this jurisprudence in this article, with a focus on the recent Ontario Superior Court of Justice decision in Mathur v Ontario. While the claims in this case were dismissed, it is …

Skin Necrosis Following Digital Wart Intralesional Injection Of Cantharidin, Sebastian Arango, Tristan Weir, Andrew Miller, Meredith Osterman

Department of Orthopaedic Surgery Faculty Papers

A right-hand-dominant female presented 5 weeks following a right middle finger intralesional cantharidin injection for a common wart by a dermatologist. The patient experienced progressive stiffness, blistering, swelling, pain, and ultimately, full-thickness skin necrosis surrounding the injection site. Careful debridement followed by a full-thickness skin graft was performed with no evidence of involvement of the germinal matrix or terminal extensor tendon. At the 7-month postoperative mark, the patient’s graft exhibited favorable healing and improved functionality that did not require further follow-up. Intralesional injection of cantharidin solutions for digital warts leads to progressive skin necrosis. Our case required prompt debridement and …

Analysis Of Patients Who Undergo Index Arthroscopy With Biopsy But Not Implantation For Staged Chondrocyte Cell Transplantation, Bryson R. Kemler, Emma E. Johnson, Brad M. Evert, Azra N. Dees, Alec M. Giakas, Adeeb Jacob Hanna, Taylor D'Amore, Kevin B. Freedman, Sommer Hammoud

Rothman Institute Papers

BACKGROUND: Autologous chondrocyte implantation (ACI) and matrix-induced autologous chondrocyte implantation (MACI) are 2-stage procedures requiring an index full-thickness cartilage biopsy. Only a portion of patients ultimately undergo second-stage ACI/MACI.

PURPOSE: To identify patients with articular cartilage defects who underwent arthroscopic debridement with biopsy for ACI/MACI and compare those who did with those who did not proceed with implantation within 2 years after biopsy. Additionally, the authors sought to identify why patients did not proceed with implantation.

STUDY DESIGN: Case-control study; Level of evidence, 3.

METHODS: Patients who underwent arthroscopy and autologous chondrocyte biopsy from January 1, 2015, to December 31, …

Panorama E Impacto De Las Feministas Jóvenes Organizadas En México: Revisión Rápida De Evidencias, Esperanza Basurto-Alcalde, Natalia E. Tenorio Tovar, Paulina Márquez González, Anel Julieta Bobadilla Negrete, Sonia Cruz Del Águila, Ricardo Regules-García

Adolescents and Young People

En México, mujeres feministas jóvenes están abriendo camino y poniendo en práctica enfoques radicales para abordar injusticias sociales como la violencia de género, la falta de atención en salud sexual y reproductiva y la discriminación por razones de Aunque las feministas jóvenes organizadas (OFJ) en México están mostrando una creciente capacidad para abogar por y lograr el cambio, hay poca evidencia sistematizada sobre las estrategias y el impacto de éstas. El objetivo general de esta Evaluación Rápida de Evidencias (REA, en inglés) es proporcionar una visión general del panorama, las estrategias y el impacto de las organizaciones de jóvenes feministas …

Overview And Impact Of Young Feminist Organizing In Mexico: Rapid Evidence Assessment, Esperanza Basurto-Alcalde, Natalia E. Tenorio Tovar, Paulina Márquez González, Anel Julieta Bobadilla Negrete, Sonia Cruz Del Águila, Ricardo Regules-García

Adolescents and Young People

In Mexico, young feminists and youth-led feminist movements are already leading the way and pursuing radical approaches to addressing social injustice, such as gender-based violence (GBV), lack of sexual and reproductive health care, and gender discrimination. Although young feminist organizations (YFOs) in Mexico are showing an increasing ability to advocate for and effect change, there is limited systematized evidence on YFO strategies and impact. This Rapid Evidence Assessment (REA) provides an overview of the YFO landscape strategies, and impact on policy and social change in Mexico from 2010 to 2023. Young feminists were defined as those aged 15 to 30. …

Rapid Evidence Assessment On The Landscape And Impact Of Young Feminist Organizing In Kenya, Chantalle Okondo, Beth Kangwana, S. Ndolo, N. Maina, Jerry Okal

Adolescents and Young People

Globally, adolescent girls, young women, and youth-led initiatives have been a crucial part of feminist and social justice struggles. In Kenya, young feminist activists, young feminist organizing / organizations (YFO) have been historically rooted in grassroots movements and are now being positioned and brought into formal spaces to play a vital role in rejuvenating, strengthening, and sustaining feminist activism. There continue to be power dynamics, systematic barriers, and harmful policies that underestimate, lock out, or disregard young feminists. This Rapid Evidence Assessment aims to provide an overview of the YFO landscape, strategies, impact on policy and social change, and challenges …

An Exploration Of The Landscape Of Young Feminist Organizing/Organizations (Yfo) In Kenya & Mexico, Jerry Okal, Ricardo Regules-García, Chantalle Okondo, Esperanza Basurto-Alcalde, Beth Kangwana

Adolescents and Young People

Over the last 10 years, numerous youth-led initiatives have emerged globally to address local development and social challenges. These initiatives focus on issues such as gender inequalities, women’s economic empowerment, gender-based violence (GBV), access to safe abortion, girls’ education, climate justice, and other social problems. The Population Council-Kenya and the Population Council-Mexico joined forces with young feminist organizations (YFOs), feminist academics, and other stakeholders to conduct participatory evaluation research. This research aimed to better understand the YFO landscape in Kenya and Mexico, including organization, operations, challenges, and shared experiences. The study provides an overview of youth-led feminist organizations in Kenya …

The Case For Adolescent Girls’ Rights And Investments In The Implementation Of The Pact For The Future And The 2030 Global Agenda: A Collection Of Global Data Insights, Girl Center

Adolescents and Young People

Globally, there has been notable progress in improving adolescent girls’ wellbeing over the past few decades. These strides have been majorly driven by commitments such as the Beijing Declaration and Platform for Action, the International Conference on Population and Development Program of Action, and the Sustainable Development Goals (SDGs). However, the progress has been uneven, especially in low- and middle-income countries—girls continue to be left behind and face gendered challenges in multiple aspects of their lives, including education, health, socio-economic aspects, digital technology use, among others, which hinder a healthy and effective transition to adulthood. Partnerships and multi-dimensional policies and …

Hereditary Spherocytosis Due To A Novel Variant, P.Q1034x, In The Beta Subunit Of The Spectrin Gene: A Case Report, Emmalee M. Kugler, Akash Patel, Faraz Afridi, Maria I. Scarano, Rafat Ahmed

Department of Emergency Medicine Faculty Papers

Background: Heterozygous pathogenic variants of SPTB cause hereditary spherocytosis (HS) in a quarter of cases. Case report: A 14-day-old male presenting with persistent anemia and hyperbilirubinemia was diagnosed with HS by increased red blood cell osmotic fragility and decreased fluorescence on the eosin-5′-maleimide binding test. For his failure to thrive and hypotonia, genetic sequencing revealed a de novo variant of the SPTB gene (p.Q1034X) on exon 15. This variant is predicted to cause loss of normal protein function either through protein truncation or nonsense-mediated mRNA decay. A variant of uncertain significance (p.R438W) in the chondroitin sulfate synthase 1 (CHSY1) gene …

Emergency Department Slit Lamp Interdisciplinary Training Via Longitudinal Assessment In Medical Practice, Samara Hamou, Shayan Ghiaee, Christine Chung, Maureen Lloyd, Kelly Khem, Xiao Zhang

Department of Emergency Medicine Faculty Papers

INTRODUCTION: Eye emergencies make up nearly 3% of US emergency department (ED) visits. While emergency physicians (EP) should diagnose and treat these ophthalmologic emergencies, many trainees report limited ocular exposure and insufficient training throughout their residency to confidently conduct a thorough slit-lamp exam.

METHODS: We created an interdisciplinary, simulation-based mastery learning (SBML) curriculum to teach emergency attending physicians how to operate the slit lamp with multimodal learning methodology at a tertiary academic center. The EPs first demonstrate their initial slit-lamp competency with a 20-item checklist, and they then review the necessary curricular content to pass their independent readiness test before …

Exploring Medical Student Experiences Of Trauma In The Emergency Department: Opportunities For Trauma-Informed Medical Education, Giselle Appel, Ahmed Shahzad, Kestrel Reopelle, Stephen Didonato, Frances Rusnack, Dimitrios Papanagnou

Department of Emergency Medicine Faculty Papers

PURPOSE: During the third-year emergency medicine (EM) clerkship, medical students are immersed in traumatic incidents with their patients and clinical teams. Trauma-informed medical education (TIME) applies trauma-informed care (TIC) principles to help students manage trauma. We aimed to qualitatively describe the extent to which students perceived the six TIME domains as they navigated critical incidents during their EM clerkship.

METHODS: We employed a constructivist, modified grounded theory approach to explore medical students' experiences. We used the critical incident technique to elicit narratives to better understand the six TIME domains as they naturally appear in the clerkship. Participants were asked to …

Digital Health Research Symposium: Closing Panel Commentary, Judd E. Hollander, Kristin L. Rising, Brian M. Dougan

Department of Emergency Medicine Faculty Papers

No abstract provided.

Endovascular Aneurysm Repair-First Strategy For Ruptured Abdominal Aortic Aneurysm Might Not Be Applicable To All Cases, Omkar Pawar, Anuja Sarode, Benjamin D. Colvard, Jae S. Cho

Faculty Scholarship

Background: We evaluate the relationship between the hospital case volume (HCV) and mortality outcomes after open aortic repair (OAR) and endovascular aortic repair (EVAR) of intact (iEVAR) and ruptured (rEVAR) abdominal aortic aneurysm (AAA) using a contemporary administrative database. Methods: The Healthcare Cost and Utilization Project Database for New York (2016) and New Jersey/Maryland/Florida (2016–2017) were queried using International Classification of Disease-10th edition to identify patients who had undergone OAR and EVAR. The hospitals were categorized into quartiles (Q) per overall (EVAR + OAR) volume, OAR-alone volume and EVAR-alone volume. Cox regression adjusted for confounding factors was used to estimate …

Association Of Glp-1 Receptor Agonists And Hepatocellular Carcinoma Incidence And Hepatic Decompensation In Patients With Type 2 Diabetes, Lindsey Wang, Nathan A. Berger, David C. Kaelber, Rong Xu

Faculty Scholarship

Background & aims: Hepatocellular carcinoma (HCC) is a leading cause of cancer death. HCC is preventable with about 70% of HCC attributable to modifiable risk factors. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), Food and Drug Administration–approved medications for treating type 2 diabetes mellitus (T2DM), have pleiotropic effects on counteracting risk factors for HCC. Here we evaluate the association of GLP-1RAs with incident HCC risk in a real-world population. Methods: This retrospective cohort included 1,890,020 patients with a diagnosis of T2DM who were prescribed GLP-1RAs or other non-GLP-1RA anti-diabetes medications and had no prior diagnosis of HCC. Incident (first-time) diagnosis of HCC …

The 2-Refined Neutrosophic Fraction Function And Its Integrals, Yaser Ahmad Alhasan, Suliman Sheen, Qusay Ahassan

Neutrosophic Sets and Systems

The goal of this article is to study the 2-refined neutrosophic fraction function and its integrals. We were defining the 2-refined neutrosophic fraction function and discussing Algorithm for finding the integral of the 2-refined neutrosophic proper rational function and introduce the integral of the 2-refined neutrosophic improper rational functions. Where each case was explained by given specific examples

A Novel And An Efficient Codas Technique To Solve Real-Life Magdm Problems In Fermatean Neutrosophic Environment, S. Bhuvaneshwari, C. Antony Crispin Sweety, Akanksha Singh, Said Broumi, Mohamed Talea, Prasanta Kumar Raut

Neutrosophic Sets and Systems

As a generalization of fuzzy sets and intuitionistic fuzzy sets, neutrosophic sets, and their combinations have been developed to represent uncertain, imprecise, incomplete, and inconsistent information existing in the real world. A neutrosophic set has the potential to be a general framework for uncertainty analysis in various spectra. On the other hand, the idea of Fermatean neutrosophic sets (FNSs) is the hybrid model of Fermatean fuzzy sets and neutrosophic sets, developed to enable the analytical management of ambiguous data from relatively typical real world decision-making scenarios. In this work, we develop an algorithm to compare the Fermatean neutrosophic set and …