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Fcrider: A Recombinant Fc Nanoparticle With Endogenous Adjuvant Activities For Hybrid Immunization, Changchuin Mao, Karen Eberle, Xiaojie Chen, Yiming Zhou, Jun Li, Hong Xin, Wenda Gao Sep 2024

Fcrider: A Recombinant Fc Nanoparticle With Endogenous Adjuvant Activities For Hybrid Immunization, Changchuin Mao, Karen Eberle, Xiaojie Chen, Yiming Zhou, Jun Li, Hong Xin, Wenda Gao

School of Graduate Studies Faculty Publications

Active immunization (vaccination) induces long-lasting immunity with memory, which takes weeks to months to develop. Passive immunization (transfer of neutralizing antibodies) provides immediate protection, yet with high cost and effects being comparatively short-lived. No currently approved adjuvants are compatible with formulations to combine active and passive immunizations, not to mention their huge disparities in administration routes and dosage. To solve this, we engineered the Fc fragment of human IgG1 into a hexamer nanoparticle and expressed its afucosylated form in Fut8−/− CHO cells, naming it “FcRider.” FcRider is highly soluble with long-term stability, easily produced at high levels equivalent to those …


News Frames For Covid-19 – A Comparison Of Australian (Australian Broadcasting Corporation) And Vietnamese (Tuoi Tre Online) Online News Services In Two Key Weeks In 2020, Viet T. Le, Lelia Green Sep 2024

News Frames For Covid-19 – A Comparison Of Australian (Australian Broadcasting Corporation) And Vietnamese (Tuoi Tre Online) Online News Services In Two Key Weeks In 2020, Viet T. Le, Lelia Green

Research outputs 2022 to 2026

This article investigates the differences and similarities between the news frames used by online mainstream media in Vietnam and Australia when reporting COVID-19 in the early waves of the pandemic. The project uses constant comparative analysis to interrogate data gathered from two online news sources: ABC Online (Australian Broadcasting Corporation) in Australia, and Tuoi Tre Online in Vietnam. The article concludes that the Australian Broadcasting Corporation coverage focuses more on social, political and economic factors than is the case with Tuoi Tre Online, which foregrounds civic responsibility in response to the COVID-19 epidemic. The Australian Broadcasting Corporation highlights how COVID-19 …


Density-Dependence Inside A Marine Protected Area Increases Natural Mortality And Stunts The Growth Of A Spiny Lobster, Emma-Jade Tuffley, Simon De Lestang Sep 2024

Density-Dependence Inside A Marine Protected Area Increases Natural Mortality And Stunts The Growth Of A Spiny Lobster, Emma-Jade Tuffley, Simon De Lestang

Fisheries Research Articles

Sustainable fisheries management often requires the modelling of stocks under unfished conditions, when the influence of population densities on animal growth and mortality can be substantial. This can be especially true for species such as spiny rock lobster, which are very habitat specific. Using western rock lobster (Panulirus cygnus) tag-recapture data from adjacent and similar fished and unfished areas, the key life history parameters of natural mortality and growth were examined and compared under different population density scenarios. In an area representative of virgin biomass levels, lobsters exhibited reduced growth rates and a substantially higher rate of natural mortality …


Mechanistic Study Of Dna Ligase Iv-Mediated Double-Strand Break Repair In Non-Homologous End Joining, Tasmin Naila, Alan E. Tomkinson Sep 2024

Mechanistic Study Of Dna Ligase Iv-Mediated Double-Strand Break Repair In Non-Homologous End Joining, Tasmin Naila, Alan E. Tomkinson

Biomedical Sciences ETDs

Non-homologous end joining (NHEJ) is a crucial double-strand break repair pathway in mammalian cells, resolving DNA damage from ionizing radiation and during V(D)J recombination. Although DNA Ligase IV is the only mammalian DNA ligase involved in NHEJ, it functions as a single-turnover enzyme in vitro. Recent cryo-electron microscopy (cryo-EM) studies revealed two LigIV molecules at the NHEJ synapse, supporting the hypothesis that two ligase molecules are needed for DSB repair by NHEJ. This study aims to validate this hypothesis by providing evidence for coordinated ligation at optimal distance and polarity preference for catalytic activity by LigIV. We determined that coordination …


Effective Strategies Used By Business Leaders In Software As A Service Industry Faced With Disruptive Technologies., Agness Allagh Sep 2024

Effective Strategies Used By Business Leaders In Software As A Service Industry Faced With Disruptive Technologies., Agness Allagh

Walden Dissertations and Doctoral Studies

Disruptive innovations such as artificial intelligence reshape marketplace dynamics and challenge traditional software as a service (SaaS) operations. Business leaders are concerned about business survival and struggle to develop effective strategies to maintain a competitive advantage and marketplace sustainability. Grounded in Teech and Pisano’s dynamic capabilities framework and Christensen’s theory of disruptive innovation, the purpose of this qualitative pragmatic inquiry study was to explore effective strategies adopted by business leaders in some SaaS industries to gain or sustain a competitive advantage when facing disruptive innovations. Seven participants in the study were SaaS industry executives in Australia, California, and New York …


Bipoc Counseling And Health Service Psychology Graduate Students’ Experience Of Racism And Sense Of Belonging: A Conditional Mediation Analysis Of Coping And Social Support, Erica Pinney Sep 2024

Bipoc Counseling And Health Service Psychology Graduate Students’ Experience Of Racism And Sense Of Belonging: A Conditional Mediation Analysis Of Coping And Social Support, Erica Pinney

Dissertations

This study sought to understand the relationship between experiences of racism within academic settings and sense of belonging to the field of Counseling/Health Service Psychology (C/HSP) for BIPOC graduate students. Further, this study sought to understand the potential mediating role of engagement coping in this relationship, as well as the conditional effect of high, neutral, or low perception of race-related social support from faculty/peers. Two-hundred forty-nine BIPOC C/HSP students responded to survey questions measuring frequency of racial/ethnic microaggressions, sense of belonging to C/HSP, engagement styles of coping with racism (Education/Advocacy and Resistance), and perception of availability of racism-related social support …


In Pursuit Of Racial Equity: The Role Of Women Presidents And Senior Leadership Teams In Higher Education, Lisa Castillo Richmond Sep 2024

In Pursuit Of Racial Equity: The Role Of Women Presidents And Senior Leadership Teams In Higher Education, Lisa Castillo Richmond

Dissertations

Colleges and universities are of the place and time in which they exist, reflecting the prevailing racial, income, and wealth inequities across society. As a result, the history of higher education in the United States tells both a story of opportunity and advancement, as well as one of exclusion, separation, and inequality. The expansion of access over time has also been accompanied by racial and socioeconomic stratification by institution type and disparities in college completion rates (Carnevale & Strohl, 2013; Fry, 2013). Today, issues of racial and socioeconomic equity continue to pose significant barriers for students. Additionally, women remain stubbornly …


Identify Best Preceptor Strategies For New Graduate Pediatric Float Pool Nurses With Learning Disabilities, Janna Berg Sep 2024

Identify Best Preceptor Strategies For New Graduate Pediatric Float Pool Nurses With Learning Disabilities, Janna Berg

EBP Fellowship

No abstract provided.


Building And Sustaining Flu Vaccine Acceptance And Trust In The Black Community Through Partnerships With Churches, Salons, And Barbershops, Henry Nuss, Lois Privor-Dumm, Chinonso Ukachukwu, Laura Lee Hall Sep 2024

Building And Sustaining Flu Vaccine Acceptance And Trust In The Black Community Through Partnerships With Churches, Salons, And Barbershops, Henry Nuss, Lois Privor-Dumm, Chinonso Ukachukwu, Laura Lee Hall

School of Public Health Faculty Publications

Despite the benefits of flu vaccines, Black adults continue to experience lower vaccination rates in the United States. Contributing factors include lack of access to health care and trusted information about vaccines. The National Minority Quality Forum's Center for Sustainable Health Care Quality and Equity collaborated with church pastors, barbers, and hair stylists to disseminate a survey to their communities to assess barriers/facilitators to flu vaccine uptake. The population (n = 262) was mostly Black (93%), female (77%), between the age of 50-64 (39%) and vaccinated (73%). The most common reasons cited by respondents for being vaccinated were personal health, …


Conducting Comparative Effectiveness, Multisite Palliative Care And Advance Care Planning Trials: Lessons Learned And Future Directions From Pcori-Funded Studies, Areej El-Jawahri, Brittany Waterman, Susan Enguidanos, Lisa Gibbs, Victor Navarro, Maren Olsen, Jennifer Temel, Annette Totten, Corita R. Grudzen Sep 2024

Conducting Comparative Effectiveness, Multisite Palliative Care And Advance Care Planning Trials: Lessons Learned And Future Directions From Pcori-Funded Studies, Areej El-Jawahri, Brittany Waterman, Susan Enguidanos, Lisa Gibbs, Victor Navarro, Maren Olsen, Jennifer Temel, Annette Totten, Corita R. Grudzen

Department of Medicine Faculty Papers

The Patient-Centered Outcomes Research Institute (PCORI) funded multiple large-scale comparative effectiveness clinical trials evaluating palliative care (PC) and advance care planning (ACP) healthcare delivery models. This article provides an overview of the most common barriers our investigative teams encountered while implementing these trials and the strategies we utilized to overcome these challenges, with particular attention to identifying research partners for multisite trials; addressing contracting and regulatory issues; creating a team governance structure; training and engaging study staff across sites; recruiting, consenting, and enrolling study participants; collecting PC and ACP data and study outcomes; and managing multisite collaborations. The goal of …


Experiences Of School Climate Among Sexual Minority Students Of Color, Brandon Westerman Sep 2024

Experiences Of School Climate Among Sexual Minority Students Of Color, Brandon Westerman

Dissertations

Since the 1980’s educational research regarding sexual minority students has continued to expand. Researchers have found that school climate can have a profound impact on sexual minority students’ outcomes, including their mental health and academic success. However, much of the research on the effects of school climate upon sexual minority students consists of studies that are predominantly composed of White participants, or the researchers do not address other aspects of participant identity. Based on the concept of intersectionality, it is known that an individual’s experiences are shaped by all their identities, not just a singular one. The purpose of this …


Treatment Of Acute Myeloid Leukemia In The Community Setting, Taha Al-Juhaishi, Servillano Dela Cruz, Rohan Gupta, Gina Keiffer, Vicki Morrison, Iuliana Shapira, Ashley Woods, Kelly Norsworthy, Romeo Angelo De Claro, Marc Theoret, Ravin Garg, Elizabeth Dianne Pulte Sep 2024

Treatment Of Acute Myeloid Leukemia In The Community Setting, Taha Al-Juhaishi, Servillano Dela Cruz, Rohan Gupta, Gina Keiffer, Vicki Morrison, Iuliana Shapira, Ashley Woods, Kelly Norsworthy, Romeo Angelo De Claro, Marc Theoret, Ravin Garg, Elizabeth Dianne Pulte

Kimmel Cancer Center Faculty Papers

The treatment landscape for acute myeloid leukemia (AML) is rapidly changing. Many new agents and lower-intensity regimens have been approved and can be safely used by hematologists and oncologists in both academic and community settings. The US Food and Drug Administration (FDA) held a virtual symposium on AML treatment in the community in November 2022. Several members of the FDA, along with practicing hematologists and oncologists in both academic and community settings, participated in the symposium. The goal of the symposium was to discuss challenges and opportunities in the treatment of patients with AML in community oncology settings. A summary …


Early Childhood Foundations Of Adolescents' Critical Consciousness In Under-Resourced And Minoritized Communities: The Roles Of Prosocial Behavior And Cognitive Self-Regulation In Middle Childhood, Zahra F. Naqi-Hasnain Sep 2024

Early Childhood Foundations Of Adolescents' Critical Consciousness In Under-Resourced And Minoritized Communities: The Roles Of Prosocial Behavior And Cognitive Self-Regulation In Middle Childhood, Zahra F. Naqi-Hasnain

Dissertations

As Black and Latino teens from under-resourced backgrounds remain vulnerable to oppressive forces, critical consciousness has emerged as a developmental asset that involves understanding, reflecting upon, and acting against inequitable social structures. However, scholars have yet to determine how critical consciousness may fit into a developmental framework, leaving unanswered questions regarding the roots of adolescents’ critical consciousness. By integrating sociopolitical and developmental frameworks, this dissertation empirically examined how early environmental factors and individual competencies set the stage for critical consciousness during adolescence, via prosocial and self-regulatory skills during middle childhood. Longitudinal data were drawn from the Chicago School Readiness Project …


Green Turtle Nesting Activity On Yeniyurt Beach, Hatay, Türkiye: Six-Year Results (2017–2022), Bektaş Sönmez Sep 2024

Green Turtle Nesting Activity On Yeniyurt Beach, Hatay, Türkiye: Six-Year Results (2017–2022), Bektaş Sönmez

Turkish Journal of Zoology

Conducting long-term conservation and monitoring activities for sea turtles provides a more precise depiction of their population status compared to studies conducted across a single year. The frequency of the nesting activity may fluctuate dramatically over time, depending on the environmental conditions. This study aimed to examine the nest count, female abundance, and reproductive output of green turtles on Yeniyurt beach in the eastern Mediterranean between 2017 and 2022. The beach was surveyed annual monitoring at consistent intervals. Temporal variations in the number of nests and the abundance of females were analyzed using the Mann-Kendall and Sen Slope tests. A …


2024-2025 Performance Forum - September 6, 2024, Samuel Dionisio, Jacob Lomboy, Sheng Yuan Kuan Sep 2024

2024-2025 Performance Forum - September 6, 2024, Samuel Dionisio, Jacob Lomboy, Sheng Yuan Kuan

Performance Forum

No abstract provided.


Size Fractionation Informs Microbial Community Composition And Interactions In The Eastern Tropical North Pacific Ocean, Madeleine A. Thompson, David L. Valentine, Xuefeng Peng Sep 2024

Size Fractionation Informs Microbial Community Composition And Interactions In The Eastern Tropical North Pacific Ocean, Madeleine A. Thompson, David L. Valentine, Xuefeng Peng

Faculty Publications

Marine microorganisms are drivers of biogeochemical cycles in the world’s oceans, including oxygen minimum zones (OMZs). Using a metabarcoding survey of the 16S rRNA gene, we investigated prokaryotic communities, as well as their potential interactions with fungi, at the coastal, offshore, and peripheral OMZ of the eastern tropical North Pacific. Water samples were collected along a vertical oxygen gradient, and large volumes were filtered through three size fractions, 0.22, 2, and 22 µm. The changes in community composition along the oxygen gradient were driven by Planctomycetota, Bacteroidota, Verrucomicrobiota, and Gammaproteobacteria; most are known degraders of marine polysaccharides and usually associated …


Bauer Recognized For Research Achievement By American Chemical Society, Brooks Payette Sep 2024

Bauer Recognized For Research Achievement By American Chemical Society, Brooks Payette

UNH Today Archive

No abstract provided.


Records Management Practices And Service Delivery: A Case Of Academic Registrar's Department At The All-Saints University Lango, Kenneth Abong, David Luyombya Sep 2024

Records Management Practices And Service Delivery: A Case Of Academic Registrar's Department At The All-Saints University Lango, Kenneth Abong, David Luyombya

School of Nursing & Midwifery, East Africa

The delivery of services in an academic department relies on its ability to manage records through good records management practices. This study was carried out to examine the records management practices in the Academic Registrar’s Department (ARD) of All Saints University Lango (ASUL) and how they impact service delivery. The objectives were to examine the types of records kept, records management practices, and the associated challenges and recommend strategies for improvement. The study used a case study design with a qualitative approach that was employed in the study. Purposive and convenient sampling was carried out on the study participants. Data …


The Effect Of Franchise No-Poaching Restrictions On Worker Earnings, Brian Callaci, Matthew Gibson, Sérgio Pinto, Marshall Steinbaum, Matt Walsh Sep 2024

The Effect Of Franchise No-Poaching Restrictions On Worker Earnings, Brian Callaci, Matthew Gibson, Sérgio Pinto, Marshall Steinbaum, Matt Walsh

Upjohn Institute Working Papers

We evaluate the nationwide impact of the Washington State attorney general’s 2018-2020 enforcement campaign against no-poach clauses in franchising contracts, which prohibited worker movement across locations within a chain. Implementing a staggered difference-in-differences research design using Burning Glass Technologies job vacancies and Glassdoor salary reports from numerous industries, we estimate a 6 percent increase in posted annual earnings from the job vacancy data and a 4 percent increase in worker-reported earnings.


Effects Of Microplastics On Aquatic Organisms: A Comprehensive Review, Sedat Gündoğdu, İrem Nur Yeşi̇lyurt, Zohaib Abbas, Makbule Baylan Sep 2024

Effects Of Microplastics On Aquatic Organisms: A Comprehensive Review, Sedat Gündoğdu, İrem Nur Yeşi̇lyurt, Zohaib Abbas, Makbule Baylan

Turkish Journal of Zoology

Microplastics (MPs) are pervasive pollutants that pose significant threats to marine ecosystems. This review examines the impact of MPs on marine organisms, highlighting key areas of concern and knowledge gaps.The aim of this paper is to synthesize recent findings on the occurrence and biological impacts of MPs in marine environments. For this purpose a total of 171 studies conducted in different geographical regions were examined in order to ascertain the interaction of numerous vertebrate and invertebrate taxonomic groups with microplastic. Based on this analysis the pathways through which MPs enter marine ecosystems and their interactions with marine organisms were examined. …


Summer Daily Activity Patterns Of Mountain Rock Lizards Of The Balkan Peninsula (Dinarolacerta Spp.), Katarina Ljubisavljević, Nataša Tomašević Kolarov, Aleksandar Urošević, Lidija Leković, Snežana Vuksanović, Tanja D. Vukov Sep 2024

Summer Daily Activity Patterns Of Mountain Rock Lizards Of The Balkan Peninsula (Dinarolacerta Spp.), Katarina Ljubisavljević, Nataša Tomašević Kolarov, Aleksandar Urošević, Lidija Leković, Snežana Vuksanović, Tanja D. Vukov

Turkish Journal of Zoology

We studied the daily activity patterns of Dinarolacerta rock lizards, endemic to the Dinaric mountains of the Western Balkans, during the summer season. The study was conducted in Montenegro at four sites for D. mosorensis and three sites for D. montenegrina. The air temperature at which the lizards were observed varied significantly both within and between species and decreased with altitude, while the temperature of the rocky ground was more stable and higher than air temperature at each study site. Males and females of both species displayed similar activity patterns, while immatures tended to be active at the time when …


Study Of Avian Migration Patterns Using Stable Isotope Analysis In The Galite Archipelago, Tunisia, Hsan Ben Jemaa, Said Nouira, François Fourel, Ilham Bentaleb Sep 2024

Study Of Avian Migration Patterns Using Stable Isotope Analysis In The Galite Archipelago, Tunisia, Hsan Ben Jemaa, Said Nouira, François Fourel, Ilham Bentaleb

Turkish Journal of Zoology

This research employed stable isotope analysis to investigate the migratory patterns and geographic origins of the Eleonora's falcon (Falco eleonorae) and its associated prey species within the Galite Archipelago, Tunisia. Feathers collected from both juvenile and adult falcons, along with their prey, were analysed for deuterium isotopic composition using the "Isorix" package in R, which facilitated the geographic assignment based on stable isotope ratios. The results demonstrated no significant difference in deuterium values (δ2H) between adult and juvenile falcons, indicating a lack of geographical variation in moulting locations among the different age groups. However, the isotopic data for adult falcons …


Dietary Observations Of Adult Pleurodema Nebulosum (Anura: Leptodactylidae) From Argentina, Gabriel Natalio Castillo, Cynthia J. González- Rivas Sep 2024

Dietary Observations Of Adult Pleurodema Nebulosum (Anura: Leptodactylidae) From Argentina, Gabriel Natalio Castillo, Cynthia J. González- Rivas

Turkish Journal of Zoology

This study is the first to examine the diet composition of adult Pleurodema nebulosum specimens based on an analysis of the gastrointestinal contents of 78 individuals. Analyzed herein were 40 specimens from a site disturbed due to anthropogenic action and 38 from a protected area in Argentina. Differences were found in the trophic consumption at both sites. In the protected area, P. nebulosum presented an active foraging mode, with a diet specialized in prey items from the Formicidae family. At the disturbed site, this amphibian showed a sit-and-wait foraging mode, with a generalist diet where it consumes Hemiptera and Coleoptera. …


Multimodal Mixing Convolutional Neural Network And Transformer For Alzheimer’S Disease Recognition, Junde Chen, Yun Wang, Adnan Zeb, M. D. Suzauddola, Yuxin Wen Sep 2024

Multimodal Mixing Convolutional Neural Network And Transformer For Alzheimer’S Disease Recognition, Junde Chen, Yun Wang, Adnan Zeb, M. D. Suzauddola, Yuxin Wen

Engineering Faculty Articles and Research

Early recognition of Alzheimer’s disease (AD) and its precursor state, mild cognitive impairment (MCI), is pivotal in interrupting the progression of the disease and providing suitable treatment. Recent development in deep learning techniques has drawn great research attention for improving the efficacy of AD recognition. However, numerous current methods solely utilize data from a single auxiliary domain, limiting their ability to harness valuable intrinsic insights from multiple domains. To cope with the challenge, this paper is devoted to establishing an innovative multimodal medical data fusion model, termed as MMDF, to perform Alzheimer’s disease recognition. Multimodal data including clinical records and …


“Get Out Of The House Before It Kills You”: Haunted Housewives And The Feminist Gothic In Ira Levin’S Rosemary’S Baby And The Stepford Wives, Sarah Jeffries Sep 2024

“Get Out Of The House Before It Kills You”: Haunted Housewives And The Feminist Gothic In Ira Levin’S Rosemary’S Baby And The Stepford Wives, Sarah Jeffries

Master's Theses

Ira Levin’s works Rosemary’s Baby and The Stepford Wives have been cultural touchstones since their releases in 1967 and 1972, respectively, with their legacy as iconic American horror stories cemented by successful film adaptations. At the surface level, these stories can be read as tales about unfortunate housewives that face unusual horrors. Rosemary Woodhouse finds herself trapped in a gothic New York City apartment building, the Bramford, where her husband and neighbors collude to force her to carry and birth Satan’s son, like a perverse Virgin Mary. Joanna Ebert is similarly stuck in suburban Stepford, Connecticut where she discovers the …


Sadomasochistic Sensations: A Phenomenological Analysis Of Black Ontology, Embodiment, And Transcendence, Sam Forrey Sep 2024

Sadomasochistic Sensations: A Phenomenological Analysis Of Black Ontology, Embodiment, And Transcendence, Sam Forrey

Master's Theses

Over the past fifteen years, feminists have challenged the notion that sexual sadomasochism perpetuates racial and gender-based violence, and instead claim that the practice can be a powerful site to control and subvert oppression. In this thesis, I contribute to this growing discourse and argue that sensations experienced during practices of Black sexual sadomasochism and attention to the feelings and affects that arise from them can be used to mediate Black being in a violently antiblack United States. Through applications of Black feminist thought, Black anti-humanism, and phenomenology, I claim that antiblack oppression denies Black people the experience of tactile …


The Skin Microbiome And Cutaneous T-Cell Lymphoma, Gail Hillary Lantaca Enriquez Sep 2024

The Skin Microbiome And Cutaneous T-Cell Lymphoma, Gail Hillary Lantaca Enriquez

Master's Theses

Skin microbiota is associated with disease activity in cutaneous T-cell lymphoma (CTCL). A common treatment for CTCL, narrowband ultraviolet B (nbUVB) phototherapy, has shown to shape the skin microbiome in association with disease improvement in other skin disorders such as atopic dermatitis. To assess the effect of nbUVB phototherapy on the skin microbiome, we performed a longitudinal analysis of skin samples of CTCL patients receiving nbUVB. We found that the treatment led to increased bacterial diversity and reduced abundances of Staphylococcus aureus and Staphylococcus lugdunensis, both bacteria known to be pathogenic. These findings imply that nbUVB treatment changes the skin …


Mental Health Care And Psychological Help-Seeking In Correctional Officers, Natasha Charles Mcqueen Sep 2024

Mental Health Care And Psychological Help-Seeking In Correctional Officers, Natasha Charles Mcqueen

Walden Dissertations and Doctoral Studies

Correctional officers face significant mental health challenges due to the high-stress and often traumatic nature of their work environments. This qualitative study used the conservation of resources (COR) theory to underpin exploration of correctional officers’ perceptions of mental health care and psychological help-seeking within personal, organizational, and societal contexts. In-depth interviews were conducted with six correctional officers, three males and three females, to gather detailed insights regarding their perceptions of mental health care and their help-seeking behaviors. Data were analyzed using manual thematic coding, NVivo, and natural language processing tools, to ensure a comprehensive and objective analysis. Key findings were …


Strategies Information Technology Project Managers Use To Enhance Information Technology Projects, Aaron Tobi Ogunjeminiyi Sep 2024

Strategies Information Technology Project Managers Use To Enhance Information Technology Projects, Aaron Tobi Ogunjeminiyi

Walden Dissertations and Doctoral Studies

Information technology (IT) projects are crucial for driving organizational growth, innovation, and competitiveness. However, when IT projects fail, they significantly threaten stakeholders, organizations, employees, and communities. These failures can severely impact performance, waste resources, erode stakeholder trust, and disrupt operations. Grounded in the theory of planned behavior, the purpose of this qualitative pragmatic inquiry was to explore strategies IT project managers used to enhance IT project’s success. The participants comprised six IT project managers of six telecommunication companies in North America with a proven record of successful project implementation. Data collection was through semistructured interviews and analyzed using thematic analysis. …


A Systematic Review Of Phenibut Withdrawals, Christopher Stewart, Hunter Simonsen, Savitha K. Satyasi, Nauman Ashraf, Suporn Sukpraprut-Braaten Sep 2024

A Systematic Review Of Phenibut Withdrawals, Christopher Stewart, Hunter Simonsen, Savitha K. Satyasi, Nauman Ashraf, Suporn Sukpraprut-Braaten

Student Publications

Phenibut is an anxiolytic agent that was originally used as a treatment for anxiety, depression, post-traumatic stress disorder (PTSD), and insomnia. It is a gamma-aminobutyric acid (GABA) mimetic, which stimulates GABA receptors in the brain. This increases the inhibitory effects of GABA leading to a greater chance of a sedative response and risk for abuse. It is not currently registered in Western countries but is easily accessible online as a supplement. This is a systematic review of case reports of phenibut patients with withdrawal symptoms published in the PubMed database between January 2010 and October 2023. Following the inclusion criteria …