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Design And Implementation Of Error Estimators For Finite Element Eigenvalue Problems, Gabriel Esteban Pinochet Soto

Dissertations and Theses

We present three publications, all encompassed under the umbrella of a posteriori error estimation theory for eigenvalue problems for finite element discretizations. The central objective of the research is the development of a general framework for the study of reliable estimation of eigenvalues and eigenspaces. We introduce applications to problems of theoretical interest as well as problems arising in real-life scenarios, such as optical fibers. The first paper focuses on the implementation of a dual-weighted residual error estimator for a nonselfadjoint eigenvalue problems arising from the study of leaky modes in optical fibers---Maxwell's equations, Perfectly Matched Layers, and a conforming …

Serum-Derived Albumin As A Cryoprotective Agent For The Long-Term Storage Of Red Blood Cells: A Preliminary Examination, Thomas Bailey-Schmidt, Christine V Saunders, Chloë E George, Thomas G Scorer, Lynn M R Mccallum, Tracey E Madgett

School of Biomedical Sciences

BACKGROUND: Cryopreservation extends the shelf life of red blood cells (RBC) from weeks to years, offering major advantages for blood banking logistics, especially in remote environments. However, current glycerol-based methods, though effective, are limited in scope due to complex post-thaw washing and incompatibility with routine clinical workflows. This study evaluated plasma-derived albumin as a potential alternative cryoprotective agent (CPA) for human RBC.

STUDY DESIGN AND METHODS: Donor-derived RBC were suspended in 25% w/v bovine serum albumin (BSA) prepared in various diluents and tested for biocompatibility and cryoprotective efficacy under rapid freezing (immersion in liquid nitrogen) and gradual freezing with storage …

Risk Factors And Prevention Strategies For Complex Regional Pain Syndrome Following Fractures: A Scoping Review, Tina Tran, Brian H. Tran, Tatum R. Dam, Ank A. Agarwal, Moorice Caparó

Student Publications

Complex regional pain syndrome (CRPS) is a neuropathic pain disorder characterized by pain disproportionate to the severity of the inciting injury, persisting beyond the expected period of tissue healing. CRPS can significantly impact functional outcomes, but despite increasing research, risk factors and preventive strategies remain incompletely characterized. The objective is to map the existing evidence on risk factors and preventive strategies for CRPS following fracture, including trauma-related, surgical, and patient-related contributors, and identify gaps in current prevention and risk stratification approaches. A comprehensive search of PubMed, Embase, and Scopus was conducted from database inception through March 17, 2026. Eligible studies …

Cohort Study Of Opioid Utilization In Post-Tonsillectomy Pediatric Patients, Sainiteesh Maddineni, Varun Vendra, Hareem Khan, Noor Ali, Tulio Valdez, Anna Messner, Iram Ahmad

Faculty, Staff and Students Publications

Objectives: Prospective observational cohort study at a tertiary care academic center to evaluate the post-operative use of oxycodone in pediatric tonsillectomy patients and caregiver knowledge of opioid disposal.

Methods: Pediatric patients 6-18 years old undergoing tonsillectomy were enrolled. Patients were excluded if they required prolonged inpatient care, had a history of organ transplantation, chronic pain or narcotic use, congenital or chromosomal disorders, inability to take acetaminophen or ibuprofen, and other significant medical diagnoses that could potentially alter postoperative pain management. All patients were prescribed a standard amount of oxycodone to be used for breakthrough pain in addition to ibuprofen and …

A Systematic Literature Review On Data-Efficient And Adaptive Learning Techniques For Encrypted Traffic Classification Under Modern Protocols, Muntakimur Rahaman, Azwan Mahmud, Azlan Abd Aziz, Osama M. S. Abujawa, Ji-Jian Chin

School of Engineering, Computing and Mathematics

Recent studies suggest that few-shot and zero-shot learning methods, drawing on meta-learning, self-supervised approaches and metric-learning ideas, can classify encrypted traffic (TLS 1.3 and QUIC) with competitive accuracy across different protocol conditions. This systematic literature review (SLR) investigates 22 studies selected from an initial pool of 500 papers using PRISMA 2020, focusing on current methodologies for non-stationary network traffic classification, with particular attention to few-shot, zero-shot, and meta-learning approaches. The research addresses four questions: (1) Which approaches have been employed for non-stationary network traffic classification and threat detection? (2) How do hybrid or cross-domain models improve adaptation, detection and overall …

Early Neurodevelopmental Outcomes In A Child With Tuberous Sclerosis Complex Treated With Everolimus And Vigabatrin, Sarah Ml Wilson, Megan Samuels, Luana Pimentel, Shelley Varnado, Claire Sartwell, Rosleen Mansour, Deborah Pearson, Hope Northrup, Mary Kay Koenig

Faculty, Staff and Student Publications

Objectives: To report early neurodevelopmental outcomes in a child with Tuberous Sclerosis Complex (TSC) treated with everolimus and vigabatrin.

Methods: The authors report a five-year-old girl with Tuberous Sclerosis Complex who was initiated on vigabatrin at seven weeks old to treat infantile spasms and on everolimus at two months of age to treat a subependymal giant cell astrocytoma. Neuropsychological assessments were conducted in this patient at 12, 24, and 36 months using the Bayley-III and Vineland-II.

Results: On the Bayley-III, the patient had a high average cognitive composite score at 12 months and a high average language composite score at …

Durand V. Nelson

All Decisions

In this no-grounds holdover, the tenant moved to dismiss, arguing the apartment was subject to VAWA, requiring specific notices. The court denied this, finding an issue of fact regarding whether the premises was a covered housing accommodation. The tenant also claimed non-receipt of a GCEL notice with the petition, but the court found it was attached electronically and the petition restated the small landlord exemption. Finally, the tenant sought dismissal for insufficient small landlord information, but the landlord's cross-motion to amend the petition to include co-owner details was granted, as no prejudice was shown. All tenant's motions to dismiss were …

Raymond Zhuang V. Pena

All Decisions

The Civil Court dismissed this no-grounds holdover because the lease lacked a conditional limitation permitting the landlord to terminate the tenancy early. The court found the relevant lease provisions did not "provide that the term of the lease will automatically expire upon the lapse of time fixed in the notice," as required. Without a valid conditional limitation, the landlord lacked a cause of action, citing Fourth Hous. Co., Inc v Bowers and 1900 Albermarle, LLC v Solon.

Mejia V. Rosas

All Decisions

In this holdover, the court grants respondent's motion to dismiss where the petition pleaded alternate theories of occupancy: either the tenant had no rights, or was a licensee and therefore failed to comply with RPAPL 741(4). This case is useful to distinguish the holding in Kew Gardens v. Bucheli, 69 Misc 3d 129(A) (App Term, 2d Dept 2020), which allows pleading inconsistent theories under certain circumstances.

Pfas Toxicity: What’S True, What’S Not, And What Really Matters, Jamie C. Dewitt, Ian T. Cousins, Gretta Goldenman, Dorte Herzke, Rainer Lohmann, Mark Miller, Carla A. Ng, Martin Scheringer, Xenia Trier, Zhanyun Wang

Graduate School of Oceanography Faculty Publications

A substantial body of evidence exists demonstrating that exposure to per- and polyfluoroalkyl substances (PFASs) poses a risk to human health. Data from epidemiological studies of those exposed occupationally or environmentally demonstrate adverse health risks, and these health effects are concordant with data from toxicological studies. Systematic reviews, conducted by agencies, organizations, and independent scientists that synthesize and integrate these data streams, have concluded that a range of health risks arise from PFAS exposure, including different types of cancer, especially kidney and testicular cancer, metabolic alterations such as increased liver enzymes and increased cholesterol, immune dysfunction such as reduced vaccination …

Politainment And Celebrity Officials In Online Journalism: A Study Of Kompas.Com And Public Discourse In Indonesia, Dewi Y. Cahyani

JURNAL KOMUNIKASI INDONESIA

This study examines how politainment shapes the news coverage of public officials with celebrity backgrounds (celebrity officials) in Indonesia's post-electoral governance context. Focusing on Kompas.com during the first six months of the Prabowo–Gibran administration, the study integrates theories and concepts of politainment, celebrity politics, and the public sphere to address a gap in global scholarship. Existing research has largely focused on Western democracies, electoral campaigns, and social media platforms, while paying limited attention to how politainment operates within professional online journalism in emerging democracies. Using a mixed-method approach that combines quantitative content analysis of 102 news articles with qualitative framing …

Design And Analysis Of Hydrogen Fuel Cell Powered Aircraft Using Wuads Design Code, Baiming Zhang, Duyen Nguyen, Mike Kiely, Ramesh Agarwal

Mechanical Engineering and Materials Science Independent Study

This report presents the application and validation of the Washington University Aircraft Design Software (WUADS) using the Dornier 228 as a representative short- to mediumrange aircraft case study. The objective of this work is to improve the reliability of the WUADS model by testing its ability to reproduce the geometry, weight, aerodynamic performance, stability characteristics, and mission behavior of an existing aircraft with known design and performance data. The Dornier 228 was selected because of its regional aircraft configuration and its relevance to future hydrogen fuel-cell aircraft studies. In this work, key aircraft parameters, including fuselage dimensions, wing geometry, passenger …

Biodegradable Pcl–Plga Electrospun Nanofibers For Localized Cancer Therapy, Rahul Tiwari, Pranav, Joel Delossantos, Eswara N.H.K. Ghali, Luis Chavez, Vishal Sharad Chaudhari, Songyang Han, Subhash Chauhan, Murali Yallapu

School of Medicine Publications

Localized chemotherapy offers a promising strategy to improve therapeutic efficacy while minimizing the systemic toxicity of conventional cancer treatment, particularly following tumor resection. Electrospun nanofibers are well suited for this purpose due to their high porosity, extracellular matrix-mimicking architecture, and capacity for localized drug release. In this study, electrospun nanofibers based on PCL and PLGA were developed for localized cancer therapy. Three distinct nanofibrous architectures were fabricated: PCL nanofibers, PCL−PLGA blended nanofibers, and PCL−PLGA multilayered (tetra-layered) nanofibers, and their encapsulation efficiency was determined by high-performance liquid chromatography (HPLC). Scanning electron microscopy confirmed uniform, bead-free nanofibrous morphologies, while Fourier transform infrared …

Preserving The Harvest: How To Preserve Chokecherries, Callahan K. Adams, Andrea Schmutz

All Current Publications

A treasured wild fruit in Utah and across the Intermountain West, chokecherries offer both cultural heritage and culinary versatility. With proper handling and research-tested preservation methods, you can safely transform them into delicious jellies, syrups, and more. Whether using a steam juicer or stovetop method, following tested recipes and adjusting for elevation ensures both safety and quality. This fact sheet provides information and recipes to safely preserve chokecherries.

Assessment Of The Bioremediation Potentials Of Biosurfactant-Producing Bacterial Strains Recovered From Spent Engine Oil-Contaminated Environments In Southwest Nigeria, Nafisa Mohammed Babayola, Nasiru Bright Lecky, Chinweizu Obioma Onumaegbu, Olufunmiso Olusola Olajuyigbe, Martins Ajibade Adefisoye

Journal of Environmental Science and Sustainable Development

Environmental pollution from hydrocarbons and their derivatives is predominantly of anthropogenic origin, occurring mainly during mining, transportation, and storage. This often in an annual release of substantial amounts of pollutants into the environment. The effective restoration of petroleum-contaminated environments requires a series of interventions to remediate soil to its natural state. This study aimed to isolate and characterize biosurfactant-producing bacterial strains with potential bioremediation capabilities to assess the potential application for remediating soils polluted with spent engine oil in the Remo district, Ogun State. Bacterial isolates were recovered from soil samples collected from spent engine oil contaminated sites, using standard …

Spontaneous Isolated Celiac Artery Dissection - A Case Report, Marina Takawy, Yousef Waly, Mohanad Shehadeh, Mostafa Najim, Richard Alweis

Advances in Clinical Medical Research and Healthcare Delivery

Introduction: Spontaneous isolated celiac artery dissection (SICAD) is a rare condition, with an unpredictable natural history. It typically affects middle aged men with risk factors including hypertension and smoking. It can remain asymptomatic, and for many patients is detected as an incidental finding. The increasing number of reported cases over the past decade has been attributed to advances in imaging modalities. Management strategies vary depending on presentation. Case presentation: We describe a case of SICAD with atypical demographics. A 77-year-old female with no smoking history presented with progressively worsening abdominal pain. Contrast-enhanced CT revealed an isolated celiac artery dissection. She …

Toxoplasmosis-Associated Immune Reconstitution Inflammatory Syndrome In A Patient With Newly Diagnosed Hiv/Aids, Shivam Singh, Divya Samat Md, Viraj Shah, Kelly Brenan-Rothschild, Anthony Donato

Advances in Clinical Medical Research and Healthcare Delivery

Background: Cerebral toxoplasmosis is a common cause of central nervous system (CNS) lesions in advanced HIV, and initiation of antiretroviral therapy (ART) can precipitate immune reconstitution inflammatory syndrome (IRIS). Toxoplasma-related IRIS is rare but poses significant diagnostic and therapeutic challenges. Case Presentation: We report a 40-year-old male with advanced HIV (CD4 <35 cells/mm3, viral load 540,000 copies/mL) who initially presented with seizures and multiple ring-enhancing supratentorial lesions. Serology and cerebrospinal fluid (CSF) polymerase chain reaction (PCR) confirmedToxoplasma gondii, and he was treated with high-dose sulfamethoxazole-trimethoprim, dexamethasone, and ART. A lymph node biopsy revealed granulomatous inflammation with intracellularHistoplasmaspecies. One month later, following brief interruption of anti-toxoplasma therapy, he developed recurrent seizures and radiographic progression despite ART adherence. Repeat evaluation excluded other infections or malignancy. Brain biopsy confirmedT. gondii, and IRIS was diagnosed. The patient improved with re-initiation of high-dose anti-toxoplasma therapy, corticosteroids, and seizure prophylaxis. Discussion: This case illustrates paradoxical toxoplasmosis-associated IRIS in the context of advanced HIV and concurrent opportunistic infection. Early recognition, exclusion of alternative diagnoses, and continuation of ART with targeted antimicrobial therapy are essential. Conclusion: Clinicians should maintain a high index of suspicion for IRIS in HIV patients with CNS …

Ultrasound-Guided Epidural Caudal Block For Lumbar Spinal Stenosis In A Patient With Severe Scoliosis: A Case Report, Theresia Chandra Tania Novy, Daniel Hadimartana, Maria Jessica Yaputri

Advances in Clinical Medical Research and Healthcare Delivery

Background: Lumbar spinal stenosis (LSS) is a common degenerative condition in the elderly characterized by narrowing of the spinal canal that leads to neural compression and symptoms such as low back pain, neurogenic claudication, and sensory disturbances. LSS may coexist with degenerative lumbar scoliosis (DLS), which can further complicate clinical presentation and management. While surgical treatment is often considered for severe cases, nonsurgical interventions remain important treatment options, particularly for elderly patients with comorbidities. Case Presentation: We report the case of a 69-year-old male presenting with chronic low back pain for more than two years, accompanied by radiating pain, numbness, …

Appendiceal Neuroendocrine Tumor: A Case Report, Daniel Zipfel, Thomas Russo, Mathew Devine

Advances in Clinical Medical Research and Healthcare Delivery

Neuroendocrine tumors (NETs) are rare neoplasms that most commonly occur in the gastrointestinal tract, lungs, and pancreas but may arise anywhere where there are neuroendocrine cells within the body. When neuroendocrine tumors metastasize to the liver, patients present with carcinoid syndrome, a group of symptoms characterized by flushing, diarrhea, and right-sided heart disease. However, many NETs do not cause carcinoid syndrome, sometimes leading to a unique clinical presentation. Patients may present with symptoms of appendicitis, ovarian torsion, or be completely asymptomatic. We report a case of a 25-year-old male with a Grade 1 neuroendocrine tumor of the appendix, who underwent …

Checkpoint Inhibitor–Associated Autoimmune Diabetes Following Pd-1 Blockade: Severe Diabetic Ketoacidosis After Pembrolizumab, Divya Samat, Osadebamwen Osaghae, Shivam Singh, Mohammad Abu Tineh, Anthony Donato

Advances in Clinical Medical Research and Healthcare Delivery

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy by enhancing antitumor T-cell activity through blockade of inhibitory pathways including programmed cell death protein 1 (PD-1) and its ligand (PD-L1). Loss of immune tolerance can lead to immune-related adverse events (irAEs), including endocrine toxicities. Checkpoint inhibitor–associated autoimmune diabetes (CIADM) is rare but clinically significant because it often presents abruptly with diabetic ketoacidosis (DKA) and profound insulin deficiency. We describe an 81-year-old male with stage III clear-cell renal cell carcinoma who developed abrupt-onset autoimmune diabetes 8 weeks after initiating adjuvant pembrolizumab. The patient presented with severe hyperglycemia and high anion-gap metabolic acidosis …

Intravenous Phenytoin-Induced Purple Glove Syndrome With Transient Hyperpigmentation: A Rare Adverse Drug Reaction In An Elderly Patient, Aarthi Ma, Revanth R

Advances in Clinical Medical Research and Healthcare Delivery

Background: Purple Glove Syndrome (PGS) is an uncommon but potentially serious adverse effect of intravenous (IV) phenytoin, characterized by limb pain, swelling, and purple-blue discoloration near the injection site. Although self-limiting in most cases, it can progress to ischemia or necrosis. Case Presentation: A 68-year-old male with a prior cerebrovascular accident (CVA) and coronary artery disease (CAD) was admitted for seizure management. He received IV phenytoin 100 mg thrice daily. By the evening of Day 1, he developed pain, edema, and purplish discoloration at the right wrist, followed by hyperpigmentation on the left palm and right-hand nails. IV …

Invasive Non-Typhoidal Salmonella Enterocolitis And Bacteraemia With Negative Initial Stool Culture Following Consumption Of ``Ceviche''- A Case Report, Maria Vasnaik, Nimrat Kaur Sandhu, Justin Nistico

Advances in Clinical Medical Research and Healthcare Delivery

Salmonellosis is a global public health concern, mainly presenting with non-specific signs and symptoms of gastrointestinal illness associated with the consumption of contaminated chicken, meat, eggs, unpasteurized milk, raw fruits and vegetables irrigated with fecally contaminated water. While non-typhoidal serotypes are known to cause mild, self-resolving symptoms, typhoidal serotypes such as Salmonella typhi and paratyphi may present with severe symptoms, including hyperpyrexia, bloody stools, osteomyelitis, and other symptoms. Such diseases are relatively uncommon in developed countries due to improved hygiene practices and are most often related to travel to endemic countries. Although vaccination against the disease has been recommended for …

A Case Of Reversible Acute Kidney Injury And Life-Threatening Gastrointestinal Bleed With Colitis In A Patient Receiving Tucatinib For Her2-Positive Breast Cancer, Geetha Keshav, Shanzae Naeem, Jalila Jafri

Advances in Clinical Medical Research and Healthcare Delivery

This case report describes the complex clinical course of a 73-year-old female with HER2-positive breast cancer enrolled in the CompassHER2 RD trial who developed acute kidney injury (AKI) requiring emergent hemodialysis shortly after initiation of tucatinib. In addition to severe renal dysfunction, the patient experienced a life-threatening lower gastrointestinal (GI) bleed in the setting of suspected drug-induced colitis and profound thrombocytopenia while receiving combination therapy with trastuzumab emtansine (T-DM1). Although tucatinib has demonstrated promising efficacy in improving outcomes for patients with high-risk HER2-positive disease, serious renal and gastrointestinal complications remain uncommon and underreported. This case underscores the importance of early …

Beyond The Algorithm: Empowering Clinicians And Researchers To Thrive In The Age Of Ai, Milan Sheth, Justin S. Brathwaite

Advances in Clinical Medical Research and Healthcare Delivery

Artificial intelligence (AI) is rapidly reshaping clinical research and healthcare delivery, yet meaningful adoption depends less on technical mastery and more on cultivating AI literacy among clinicians and research staff. Building a foundational understanding of concepts such as supervised learning, bias, and model validation enables professionals to interpret and apply AI-generated insights with confidence. Familiarity grows through exposure to AI-enabled electronic medical record systems, interdisciplinary collaboration with data scientists and informaticists, and small pilot projects that demonstrate workflow fit and real-world value. Prioritizing transparency, explainability, and ethical considerations ensures that AI augments clinical decision-making. Practical applications already span oncology research, …

Solutions To Dismantling Osteopathic Bias In American Medicine, Mathew Devine, Richard Terry

Advances in Clinical Medical Research and Healthcare Delivery

No abstract provided.

Addressing Doscrimination: Examining Bias Against Osteopathic Physicians, Sophia M. Valerino

Advances in Clinical Medical Research and Healthcare Delivery

Osteopathic medicine arose as a response to the limitations of conventional medical practices of the time. It emphasizes the body's innate ability to heal and the importance of holistic care and has since evolved into a rigorous and evidence-based system that parallels allopathic education in scope, standards, and licensure. Nevertheless, osteopathic physicians (DOs) continue to face systemic bias across multiple areas. This article examines the historical context and current manifestations of discrimination against DOs, highlighting disparities in residency selection, research participation, academic leadership, and media portrayal. Despite clear evidence showing comparable performance between DOs and MDs in clinical care and …

Vitamin D Deficiency And Risk Of Cognitive Decline And Dementia: Implications And Prevention Strategies, Auda Fares

Advances in Clinical Medical Research and Healthcare Delivery

Emerging evidence suggests a link between vitamin D deficiency and an increased risk of cognitive impairment and dementia, including Alzheimer's disease (AD). This paper reviews the epidemiological evidence, explores potential mechanisms underlying this association, and discusses implications for prevention strategies. Current supplementation strategies may not be fully effective due to individual variability. Personalized interventions based on genetic factors and routine vitamin D status testing in older adults are proposed as future directions for optimizing the impact of vitamin D supplementation in dementia prevention.

Nationwide Analysis Of Catheter-Directed Thrombolysis Versus Anticoagulation In Sub-Massive Pulmonary Embolism, Ayushma Acharya, Swarup Sharma Rijal, Anthony Donato

Advances in Clinical Medical Research and Healthcare Delivery

Background: Data on the real-world effectiveness and safety of catheter-directed thrombolysis (CDT) versus anticoagulation in sub-massive pulmonary embolism (PE) remain limited.

Objective: The aim of this study was to assess the differences in in-hospital mortality, length of stay (LOS), complications and healthcare resource utilization between catheter directed thrombolysis and anticoagulation in sub-massive pulmonary embolism using the National Inpatient Sample (NIS) dataset from 2016–2022.

Methods: The National Inpatient Sample (2016–2022) was queried to identify hospitalizations for sub-massive pulmonary embolism (PE) with cor pulmonale. Patients receiving CDT were compared to those treated with anticoagulation alone. We excluded patients with shock, ventilator …

Decoupled Dependency Management Architecture, Aman Singh, Kenny Maclean

Defensive Publications Series

This paper describes a technique for physically segregating machine-generated dependency metadata from human-authored build logic using a "Sidecar Architecture" within a build system environment. The system includes an automated sidecar module containing a structured data dictionary, a primary human-maintained build configuration that imports this dictionary, and an integration logic macro that merges these external components with user-defined components to construct a final dependency graph.

Gci-312 — Adaptive Agricultural Microclimate Conditioning System For Arid Environments, Michael Victor Caldwell Mr.

Defensive Publications Series

GCI‑312 is an open‑source, prototype‑ready adaptive agricultural microclimate conditioning system integrating electrostatic‑assisted droplet deposition, vortex atomization, pulsed evaporative cooling, environmental telemetry, and root‑zone thermal stabilization to experimentally reduce convective moisture loss and crop heat stress in arid environments. This disclosure provides full build and test specifications so a reader can assemble a 10×10 ft test cell and begin staged experiments immediately. The project targets substantial irrigation demand reductions under arid heat‑stress conditions (experimental targets: 20–30% irrigation reduction; exploratory upper target if all subsystems validate: up to 30–50% reduction) and documents clear hypotheses, test metrics, kill criteria, pivot paths, energy accounting, …