Digital Commons Network^™

Metadegron: Multimodal Feature-Integrated Protein Language Model For Predicting E3 Ligase Targeted Degrons, Mengqiu Zheng, Shaofeng Lin, Kunqi Chen, Ruifeng Hu, Liming Wang, Haodong Xu

Faculty, Staff and Student Publications

Protein degradation through the ubiquitin proteasome system at the spatial and temporal regulation is essential for many cellular processes. E3 ligases and degradation signals (degrons), the sequences they recognize in the target proteins, are key parts of the ubiquitin-mediated proteolysis, and their interactions determine the degradation specificity and maintain cellular homeostasis. To date, only a limited number of targeted degron instances have been identified, and their properties are not yet fully characterized. To tackle on this challenge, here we develop a novel deep-learning framework, namely MetaDegron, for predicting E3 ligase targeted degron by integrating the protein language model and comprehensive …

Dek::Aff2 Fusion-Associated Squamous Cell Carcinoma: A Case Series With Literature Review On An Emerging And Challenging Entity, Sara E Amin, James S Lewis, Julia A Bridge, Jen-Fan Hang, Udit Naik, Justin A Bishop, Karan Saluja

Faculty, Staff and Student Publications

Purpose: DEK::AFF2 fusion-associated squamous cell carcinoma (DEK::AFF2 SCC), also reported in the literature as low-grade papillary sinonasal (Schneiderian) carcinoma (LGPSC), is a rare, primarily bland-appearing, but locally aggressive neoplasm. Morphologically, these tumors can closely resemble sinonasal papilloma (SP), especially on small or limited biopsy, often leading to misdiagnosis. DEK::AFF2 SCC is devoid of the underlying mutually exclusive EGFR or KRAS driver mutations of SP, suggesting it may represent a distinct unique entity.

Methods: In this study, we conducted a retrospective search of "unusual" SP reported either as atypical, dysplastic, or suspicious for malignant transformation at our institution in the last …

Thrombectomy For Stroke With Large Infarct On Noncontrast Ct: The Tesla Randomized Clinical Trial, Ansaar T Rai, Ramesh Grandhi, Hugo Cuellar, Maxim Mokin, Jeffrey M Katz, Amer Alshekhlee, Muhammad A Taqi, Sameer A Ansari, Adnan H Siddiqui, Nobl Barazangi, Joey D English, Alberto Maud, Jawad Kirmani, Rishi Gupta, Dileep R Yavagal, Jason Tarpley, Dhruvil J Pandya, Marshall C Cress, Sushrut Dharmadhikari, Kaiz S Asif, Tareq Kass-Hout, Ajit S Puri, Nazli Janjua, Aniel Q Majjhoo, Aamir Badruddin, Randall C Edgell, Rakesh Khatri, Larry Morgan, Anmar Razak, Alicia Zha, Priyank Khandelwal, Nils Mueller-Kronast, Dennis J Rivet, Thomas Wolfe, Brian Snelling, Ali Sultan-Qurraie, Shao-Pow Lin, Rajkamal Khangura, Alejandro M Spiotta, Parita Bhuva, Sergio Salazar-Marioni, Eugene Lin, Abdul R Tarabishy, Edgar A Samaniego, Murali K Kolikonda, Mouhammad A Jumaa, Vivek K Reddy, Pankaj Sharma, Olvert A Berkhemer, Pieter-Jan Van Doormaal, Adriaan C G M Van Es, Wim H Van Zwam, Bart J Emmer, Ludo F Beenen, Charles B L M Majoie, Nancy Buderer, Michelle A Detry, Anna Bosse, Todd L Graves, Christina Saunders, Lucas Elijovich, Ashutosh Jadhav, Mary Patterson, Hannah Slight, Kristine Below, Sami Al Kasab, Tesla Investigators

Faculty, Staff and Student Publications

Importance: Recent large infarct thrombectomy trials used heterogeneous imaging modalities and time windows for patient selection. Noncontrast computed tomographic (CT) scan is the most common stroke imaging approach. It remains uncertain whether thrombectomy is effective for patients with large infarcts identified using noncontrast CT alone within 24 hours of stroke onset.

Objective: To evaluate the effect of thrombectomy in patients with a large infarct on a noncontrast CT scan within 24 hours of onset.

Design, setting, and participants: Open-label, blinded-end point, bayesian-adaptive randomized trial with interim analyses for early stopping (futility or success) or population enrichment, which was conducted at …

The Composite Projection Configuration That Contains 8 Projection Configurations Which Are Collectively Configured In An Octagonal Configuration., Punarjeewa Abeysekera

Defensive Publications Series

This paper describes a composite projection configuration that contains 8 projection configurations which are collectively configured in an octagonal configuration. The composite projection configuration consists of 8 identical projection configurations. Each projection configuration will contain a video projecting display, a convex lens stack and an angled beam splitter. The composite projection configuration, by collectively utilizing the 8 identical projection configurations, will have the capability to project 8 projections onto the field of view of the user. And the composite projection configuration, by collectively utilizing the 8 projections, will have the capability to combine the 8 projections into a one single …

Spherical Radius Hanger

Defensive Publications Series

A surface wellhead assembly having an inner tubular insertable into an outer tubular, is described. A tubing hanger is provided on an outer surface of the tubing head housing for sealing between the hanger and housing. The contact sealing of tubing hanger has a shepherd.

When the inner tubular member is landed, a portion of the shepherd radius adjacent to the outer taper seal of tubing housing tapers radially inward into sealing contact when the tubing hanger or tubing housing is not perfect perpendicular.

Enduring Heroism In The Face Of Inequality And Injustice: Who Steps Up And Why?, Carol D. Ryff

Heroism Science

Enduring heroism defined as persistent efforts to confront inequality and injustice is the focus of this article. Six exemplars are considered: Harriet Tubman, Crazy Horse, Jane Addams, Mohandas Gandhi, Nelson Mandela, Malcolm X. Similarities and differences in their pursuits are considered and linked to the larger literature on heroism. They are also contrasted with enduring anti-heroes to elevate roles of virtue and benevolence in long-term efforts to correct societal ills. What motivates enduring heroism is a central question. A hypothesis put forth is that distinct dimensions of eudaimonic well-being – especially, purpose in life, autonomy, environmental mastery, and personal growth …

Lucindy Wiggins

African American Funeral Programs

Mrs_Lucindy_Wiggins.pdf - Death Notice for Lucindy Wiggins.

Mr. Egell Wilcox

African American Funeral Programs

Mr_Egell_Wilcox.pdf - Death notice for Egell Wilcox

Cassandra Ra'na Mathis Wilcox

African American Funeral Programs

Cassandra_Ra'na_Mathis_Wilcox.pdf - Funeral program for Cassandra Ra'na Mathis Wilcox

Sgt. Theodore Garfield White

African American Funeral Programs

Sgt_Theodore_Garfield_RemainsReturned.pdf notice of Sgt. Theodore remains being returned to Statesboro by the United States Army

Synthesis And Characterization Of Uio-66-Nh2 (Zr) Metal–Organic Frameworks: Chitosan And Its Aminated Derivatives To Remove Toxic Cr (Vi) From Industrial Wastewater, Bassma M. Ali, Zainab Ali, Elen Emad, Ragaa Ahmed, Ayat Khasawneh, Khalideh Al Bkoor Alrawashdeh, Rebhi A. Damseh, Jalal A. Al-Tabbal, Kamel K. Al-Zboon, Petros Samaras, Yasser Dessouky, Kareem Tonbol

Blue Economy

This study used adsorbent hydrogel beads on chitosan coated with the commercially prepared metal-organic framework (MOF) and its aminated derivative to chromium (VI) ions from their aqueous solutions. Higher removal (%) and higher adsorption capacity values were recorded using chitosan and its aminated derivatives, UiO-66-NH₂ (Zr) (0.5 % CS) adsorbent (87 % and 95 mgg^-1), respectively, compared with those using CS adsorbent (86% and 93 mg/g using 1% CS); contact time was 180 min, with maximum removal (%) reaching 87% and maximum adsorption capacity of 95 mgg^-1. The pH of the studied medium was in …

Scientific Programs In The Arab Media - Reality And Gap, Najm Abed Khalaf Aleessawi

The article aimed to reveal the level of Arab media coverage of specialized scientific topics and to know the actual need for such programs, especially with the tremendous developments in various fields of life. The descriptive analytical approach was adopted, and a questionnaire tool was used, which was distributed to (205) Arab academics and researchers who were selected by a simple random sampling method. The study found that coverage of scientific programs in the Arab media at the local level is not at the required level. Social media platforms are the most widely used media means for accessing scientific programs …

Melanism In Polymorphic Terrestrial Snakes: A Meta-Analysis And Systematic Review, Ryan A. Martin

Faculty Scholarship

Background and Aim: Colour polymorphic populations constitute excellent model systems for testing ecological and evolutionary hypotheses, as alternate colourations are associated with differences in various biological, behavioural and life-history traits. Melanism is the most common and most obvious form of polymorphism. In reptiles in general (and snakes in particular), thermal melanism has been a popular hypothesis used to explain the appearance of black individuals. It suggests that a trade-off exists between superior thermoregulation and reduced protection through the loss of crypsis. Surprisingly, despite the growing body of literature available, to date, there are only two qualitative reviews on the evolutionary …

Community-Led Climate Preparedness And Resilience In Boston: New Evidence From Communities Of Color, Katsyris Rivera-Kientz, Rosalyn Negron, Lorena Estrada-Martínez, Nyingilanyeofori Hannah Brown, Chidimma Ozor Commer, Mahesh Admankar, Jessica Lillquist, Nicholas Johnson, Racheal Inegbedion, Paul Watanabe

Sustainable Solutions Lab

Communities of color have been historically excluded and marginalized in the ongoing conversations about climate preparedness and resilience at local, national, and global levels. Using focus groups composed of Boston communities of color (Asian American, Black, Latino, and Native American), this study aimed to understand their perspectives on climate change, providing in-depth knowledge of its impact and their views on preparedness and resilience. Research shows that these communities have long been concerned about climate change and emphasize the urgent need to improve climate preparedness. A multi-pronged approach is crucial: listening to communities of color to leverage local knowledge and leadership, …

University Ranks Among 'Great Colleges To Work For' For 15th Year, Clara Turnage

University of Mississippi News

OXFORD, Miss. – The University of Mississippi is again one of the nation's "Great Colleges to Work For," according to The Chronicle of Higher Education.

Hispanic Heritage Percussion Recital, Arkansas State University Department Of Music

Performance Programs

No abstract provided.

Scattering Spectroscopy Of Granular Media For Remote Sensing Applications, Chris H. Lee

Theses

The reflectance of a surface depends not only on the physical characteristics of the medium, but also on the geometry of how the surface is illuminated and viewed. Remote sensing data of a surface at multiple illumination and/or viewing angles can provide additional information that we can use to retrieve the physical properties of the surface and/or underlying medium as opposed to remotely sensed data at a single geometry. In this work, I characterized different aspects of angular reflectance, or scattering, spectroscopy of granular media for remote sensing applications. I applied polarimetry to various samples of olivine sand as a …

Activity 5: Reimagining A Space On Campus (In-Class), Ashley Baber

Ashley Baber, Better Citites: Urban Problem-Solving

No abstract provided.

Assignment 2: Op-Ed Writing Assignment Part 1, Ashley Baber

Ashley Baber, Better Citites: Urban Problem-Solving

No abstract provided.

Syllabus: Better Cities - Urban Problem Solving (Soc/Url 381), Ashley Baber

Ashley Baber, Better Citites: Urban Problem-Solving

No abstract provided.

Assignment 2, Part 2, Item 3: Op-Ed Assignment Part 2, Ashley Baber

Ashley Baber, Better Citites: Urban Problem-Solving

No abstract provided.

Assignment 6: Public Comment At A Community Meeting, Ashley Baber

Ashley Baber, Better Citites: Urban Problem-Solving

No abstract provided.

Leveraging Convolutional Neural Network (Cnn)-Based Auto Encoders For Enhanced Anomaly Detection In High-Dimensional Datasets, Aetsam Javad, Madiha Anjum, Hassan Ahmed, Arshad Ali, H. M. Shahzad, Hamayun Lhan, Abdulaziz M. Alshahrani

Business Faculty Publications

This study presents an Auto-Encoder Convolutional Neural Network (AECNNs) approach for anomaly detection in high-dimensional datasets. Unsupervised learning-based algorithms have a strong theoretical foundation and are widely used for anomaly detection in high-dimensional datasets, but some limitations significantly reduce their performance. This study proposes an algorithm to address these limitations. The proposed AECNN combines various convolutional layers, feature extraction, dimensionality reduction, and data preprocessing and was evaluated using accuracy, precision, recall, and F1-score. The performance of the proposed model was evaluated using a large real benchmark dataset. The proposed CNN-based autoencoder distinguished anomalies with an AUC score of 0.83 and …

Assignment 4: Urban Analysis, Ashley Baber

Ashley Baber, Better Citites: Urban Problem-Solving

No abstract provided.

Hydrogen-Peroxide Intercalated Expanded Graphite Facilitates Large Enhancement In Thermal Conductivity Of Polyetherimide/Graphite Nanocomposites, Fatema Tarranum, Swapneel Danayat, Avinash Nayal, Zarin Tasmin Mona, Roshan Sameer Annam, Keisha Walters, Jivtesh Garg

Chemical Engineering Faculty Publications and Presentations

In this work, we prepared expanded graphite (EG) filler using hydrogen peroxide (H₂O₂) as an oxidizing agent to study its impact on the thermal conductivity (k) of polyetherimide (PEI) composite, compared to EG prepared using sodium chlorate (NaClO₃). Sulfuric acid was used as the primary intercalating agent for both synthesis routes. The use of H₂O₂ prepared EG (EG-H₂O₂) led to a remarkable ∼4030% enhancement (9.5 Wm⁻¹K⁻¹) in k of the PEI/EG composite, while the use of NaClO₃ prepared EG (EG-NaClO …

The Extent And Burden Of High Multimorbidity On Older Adults In The Us: A Descriptive Analysis Of Medicare Beneficiaries, David A. Dorr, Sheila Markwardt, Michelle Bobo, Heather G. Allore, Anda Botoseneanu, Jason T. Newsom, Corey Nagel, Ana R. Quiñones

Psychology Faculty Publications and Presentations

Background:

The impact of multimorbidity (≥ 2 chronic diseases) on the well-being of older adults is substantial but variable. The burden of multimorbidity varies by the number and kinds of conditions, and timing of onset. The impact varies by age, race, ethnicity, socioeconomic status, and health indicators. Large scale longitudinal surveys linked to medical claims provide unique opportunities to characterize this variability. Methods We analyzed Medicare-linked Health and Retirement Study data for respondents 65 and older with 3 or more years of fee-for-service coverage (n = 17,199; 2000–2016). We applied standardized claims algorithms for operationalizing 21 chronic diseases. We compared …

Mutual Relationships Of Nanoconfined Hexoses: Impacts On Hydrodynamic Radius And Anomeric Ratios, Bridget L. Gourley, Mia R. Halliday, Samantha L. Miller, Christopher D. Gale, Jenna R. Deckard, Nancy E. Levinger

Chemistry & Biochemistry Faculty Publications

Although all hexose sugars share the same chemical formula, C6H12O6, subtle differences in their stereochemical structures lead to their various biological roles. Due to their prominent role in metabolism, hexose sugars are commonly found in nanoconfined environments. The complexity of authentic nanoconfined biological environments makes it challenging to study how confinement affects their behavior. Here, we present a study using a common model system, AOT reverse micelles, to study hexose sugars in nanoconfinement. We examine how reverse micelles affect the hexoses, how the hexoses affect reverse micelle formation, and the differences between specific hexoses: glucose, mannose, and galactose. We find …

Fifteen Years Of Findings: Advancements In Spring Dead Spot Research From 2009 To 2024, W. J. Hutchens, J. K. Anders, E. L. Butler, J. P. Kerns, D. S. Mccall, G. L. Miller, N. R. Walker

Horticulture Faculty Publications and Presentations

Spring dead spot (Ophiosphaerella spp.; SDS) is one of the most detrimental diseases to warm-season turfgrasses, particularly bermudagrass (Cynodon spp.), growing in climates where cold temperatures induce dormancy. The pathogen can infect the crowns, stolons, rhizomes, and roots of bermudagrass most of the year, but infection in the fall predisposes the turf to winter injury and plant death. Symptoms typically appear the following spring, making management of SDS challenging. Moreover, the biology, epidemiology, and management of SDS are not fully understood. Ample research has been conducted on SDS which was thoroughly summarized before 2009 by Tredway et al. …

Tree Diversity Across The Minneapolis-St. Paul Metropolitan Area In Relation To Climate And Social Vulnerability, Adrienne B. Keller, Leslie A. Brandt, Jeannine Cavender-Bares, Joseph F. Knight, Sarah E. Hobbie

Michigan Tech Publications

Urban tree canopy cover is often unequally distributed across cities such that more socially vulnerable neighborhoods often have lower tree canopy cover than less socially vulnerable neighborhoods. However, how the diversity and composition of the urban canopy affect the nature of social-ecological benefits (and burdens), including the urban forest's vulnerability to climate change, remains underexamined. Here, we synthesize tree inventories developed by multiple organizations and present a species-specific, geolocated database of more than 600,000 urban trees across the 7-county Minneapolis-St. Paul (MSP) metropolitan area in the Upper Midwest of the United States. We find that tree diversity across the MSP …

Comparing The Health Information Practices Of Sapphic People By Age Group And Generation, Vanessa Lynn Kitzie

Faculty Publications

This qualitative research examines how sapphic people (i.e., umbrella term inclusive of lesbian, bisexual, and pansexual trans femmes, mascs, nonbinary people, and ciswomen) in South Carolina navigate informational barriers within healthcare systems. An information practices lens that examines how sapphic people create, seek, use, and share information to achieve desired healthcare outcomes describes such navigation. The research focuses on how intersectional identities, with a particular emphasis on age and considerations of race/ethnicity, geography, and gender, mediate these practices and their outcomes. The research uses participant data from semi-structured interviews and focus groups with 34 sapphic people about their health information …