Digital Commons Network^™

Health Risk Factors Of Female African American Informal Caregivers For Alzheimer’S Disease Patients In Low-Income Communities, Rosaline Elaine Elliott

Walden Dissertations and Doctoral Studies

By 2050, 152 million people worldwide, primarily low-income populations, will have Alzheimer's disease (AD). African American (AA) women informal caregivers are primary caregivers in low-income neighborhoods, and they suffer from burnout and poor health, including physical and mental fatigue, despair, anxiety, hypertension, and stressors that can lead to heart attacks, strokes, or premature mortality. The Informal Caregiver Integrative Model (ICIM) theoretical framework was used to survey 120 participants using SurveyMonkey was administered to collect data for this cross-sectional quantitative study. The multiple hierarchical regression analyses revealed caregiving appraisal had no significant impact on burnout. A higher quality of the caregiver-care …

Successful Strategies Used By Information Technology Talent Acquisition Managers To Retain Niche Employees, Lucie Tuttle

Walden Dissertations and Doctoral Studies

Ineffective retention strategies for niche information technology (IT) employees can negatively impact business technological capabilities. Talent acquisition managers who struggle to retain niche IT employees beyond 2 years are at a high risk of business instability. Grounded in the job characteristics model, job characteristics theory, and expectancy theory, the purpose of this pragmatic qualitative inquiry was to explore strategies IT talent acquisition managers use to retain niche employees beyond 2 years. The participants were six IT talent acquisition managers who had effectively implemented strategies to retain niche employees beyond 2 years. Data were collected using semistructured interviews, public websites, and …

Policy Tools For Youth Development In African American Communities, Adedapo Oladipo Adeyanju

Walden Dissertations and Doctoral Studies

Many African American adolescents live in disadvantaged neighborhoods due to decades-long segregationist housing policies. Living in these settings have isolated them from mainstream society and put them at risk for developmental issues and engagement in risky behaviors and violent crime as young adults. The purpose of this study was to examine past experiences of public housing beneficiaries exposed to concentrated poverty and their perceptions of how their neighborhood characteristics affect adolescent development. Research questions examined how housing policies have inhibited development or isolated Black youths to specific housing programs, affecting their opportunities to be better citizens. The theoretical framework for …

Parents’ Perception Of Family Dynamics When Their Children Use Video Games Excessively, Joseph Benjamin Collins

Walden Dissertations and Doctoral Studies

Excessive video game use among youth has been linked to communication problems within families and disrupted family dynamics, notably reducing time spent with family members and reinforcing withdrawal from family activities and other recreational pursuits. While quantitative research has addressed the connection between children’s excessive video gaming and its negative impact on family dynamics, a deeper understanding of parents' perceptions remained needed. This study aimed to explore how parents described family dynamics when their children engaged in excessive gaming, using attachment theory as the theoretical framework. Data were collected through semistructured interviews with 12 parents, and thematic analysis was used …

Strategies For Implementing Organizational Change In The Construction Industry, Ivette Dejesus

Walden Dissertations and Doctoral Studies

Construction business leaders are concerned with failed change initiatives as they have the potential to affect profitability. Grounded in five-P theory, the purpose of this qualitative multiple case study was to explore the strategies that some leaders in construction companies use to implement change initiatives successfully. The participants consisted of five business leaders from three construction companies who have successfully implemented change initiatives within their organization. Data were collected using semi-structured interviews and a collection of organizational documents. Through thematic analysis, five themes emerged: (a) goal setting and planning, (b) effective communication, (c) stakeholder involvement, (d) effective resource and cost …

Stakeholder Expectations Using Co-Teaching To Improve Mathematics Instruction For Students With Disabilities, Leslie Wigginton Schnars

Walden Dissertations and Doctoral Studies

When special education was first introduced into the general education environment, students were served in separate classrooms. Throughout the years, special education services have evolved and students with mild to moderate disabilities are now educated alongside their non-disabled peers. The foundation of the social interdependence theory is that outcomes are often determined by individual interactions and the interdependence structured in specific situations. For this interdependence to be present, more than one person must be involved and changes in one person must impact change in the others participating. This is part of the foundation of co-teaching. While there is a great …

Volunteer Engagement Strategies To Increase Use Of Knowledge Assets In Small Nonprofits, Samantha Tyler

Walden Dissertations and Doctoral Studies

Volunteers play a critical role in supporting nonprofit organizations, and when engaged, volunteers drive organizational growth and positive social impact. Small nonprofit volunteer workforce leaders are concerned with volunteer engagement to mitigate attrition and increase knowledge assets, ensuring quality organization performance. Grounded in stakeholder theory and supported by Vroom’s expectancy theory and knowledge transfer theory, the purpose of this qualitative single case study was to explore volunteer engagement strategies that leaders of a small nonprofit organization used to increase knowledge assets and organization performance. The participants were three leaders of a single western U.S. nonprofit organization: one executive director and …

Video Spotlight - Using Search Limiters, Diamond R. Williams

Libraries' Documents

No abstract provided.

Know Your Library - Production Studio, Diamond R. Williams

Libraries' Documents

No abstract provided.

Know Your Library - Podcast Studio, Diamond R. Williams

Libraries' Documents

No abstract provided.

Power, Voice, And Agency: Empowering Adolescent Girls And Young Women Through Multiple Interventions For Evidence-Informed Contraceptive Decisions, Evalin Karijo, Karen Austrian, Miriam Temin, Mame Soukeye Mbaye

Adolescents and Young People

This blog is part of a series in partnership with Population Council, Reproductive Health Supplies Coalition (RHSC), and Population Services International (PSI), to recognize World Contraception Day 2024. It was originally published on the Council's website.

Body, Loss, Memory And Healing: Three Emerging Emirati Women Artists, Ioannis Galanopoulos Papavasileiou, Aysha Al Dhaheri, Mariam Al Mansoori, Sara Alqardaeai

All Works

The UAE is rapidly transforming into a global cultural hub with the establishment of prominent institutions such as the Sheikh Zayed National Museum, the Louvre, and the Guggenheim in Abu Dhabi. Sharjah hosts the Exposure International Photo Festival and an art biennale, with a historic district featuring numerous museums and galleries. Dubai is home to Art Dubai, a leading international art fair in the Middle East, and recently hosted the World Expo and COP28. These developments not only highlight the UAE as a dynamic business hub driven by the petroleum and energy sectors but also position it as an attractive …

Mental Health During The Covid-19 Pandemic In Trinidad: An Analysis Of Depression, Anxiety, And Stress Among Essential Workers, Bernadette Marson, Gerard A. Hutchinson

Journal of Social, Behavioral, and Health Sciences

Research shows that some essential workers, such as healthcare workers, social workers, and first responders (including police officers, paramedics, and firefighters), are at greater risk for developing both short- and long-term mental health problems (Berger et al., 2012; Canady, 2022; Grey et al., 2020; Haugen et al., 2012; Mohamed et al., 2022; Petrie et al., 2018). The most prevalent of these include anxiety, depression, and stress, as well as other social and cognitive problems—with stress causing harmful effects on mental health and potentially resulting in anxiety and depression, which may then disrupt an individual’s social relationships, family life, and work. …

Evaluating The Impact Of A Year-Long External Mentorship Pilot Program In Classical Hematology, Zoya Qureshy, Pooja Nair, Sara K Vesely, Allison A King, Alfred I Lee, Nathan T Connell, Annette Von Drygalski, Ida Wong-Sefidan, Martina C Murphy, Ronak H Mistry, Rebecca L Zon, Erin G Reid, Josel Fritz, Soo J Park

2020-Current year OA Pubs

Effective mentorship is a pivotal factor in shaping the career trajectory of trainees interested in classical hematology (CH), which is of critical importance due to the anticipated decline in the CH workforce. However, there is a lack of mentorship opportunities within CH compared with medical oncology. To address this need, a year-long external mentorship program was implemented through the American Society of Hematology Medical Educators Institute. Thirty-five hematology/oncology fellows interested in CH and 34 academically productive faculty mentors from different institutions across North America were paired in a meticulous process that considered individual interests, experiences, and background. Pairs were expected …

Intracranial Aneurysms In Sickle Cell Disease Are Associated With Hemodynamic Stress And Anemia, Yan Wang, Jared S Garland, Slim Fellah, Martin N Reis, Matthew S Parsons, Kristin P Guilliams, Melanie E Fields, Amy E Mirro, Josiah B Lewis, Chunwei Ying, Rachel A Cohen, Monica L Hulbert, Allison A King, Yasheng Chen, Jin-Moo Lee, Hongyu An, Andria L Ford

2020-Current year OA Pubs

Although hemodynamic stress plays a key role in aneurysm formation outside of sickle cell disease (SCD), its role is understudied in patients with SCD. We hypothesized that tissue-based markers of hemodynamic stress are associated with aneurysm presence in a prospective SCD cohort. Children and adults with SCD, with and without aneurysms, underwent longitudinal brain magnetic resonance imaging/magnetic resonance angiography (MRA) to assess cerebral blood flow (CBF) and oxygen extraction fraction (OEF). Baseline characteristics were recorded. In the subgroup of adults, stepwise mixed-effect logistic regression examined clinical variables, CBF, and OEF as predictors of aneurysm presence. Cumulative rates of new aneurysm …

The Trim4 E3 Ubiquitin Ligase Degrades Tpl2 And Is Modulated By Oncogenic Kras, Sapana Bansod, Paarth B Dodhiawala, Yutong Geng, Ashenafi Bulle, Peng Liu, Lin Li, Reid Townsend, Patrick M Grierson, Jason M Held, Hema Adhikari, Kian-Huat Lim

2020-Current year OA Pubs

Loss-of-function mutations in the C terminus of TPL2 kinase promote oncogenesis by impeding its proteasomal degradation, leading to sustained protein expression. However, the degradation mechanism for TPL2 has remained elusive. Through proximity-dependent biotin identification (BioID), we uncovered tripartite motif-containing 4 (TRIM4) as the E3 ligase that binds and degrades TPL2 by polyubiquitination of lysines 415 and 439. The naturally occurring TPL2 mutants R442H and E188K exhibit impaired TRIM4 binding, enhancing their stability. We further discovered that TRIM4 itself is stabilized by another E3 ligase, TRIM21, which in turn is regulated by KRAS. Mutant KRAS recruits RNF185 to degrade TRIM21 and …

Burden Of Diabetes Mellitus In The Medically Underserved Rio Grande Valley, John M. Gaddis, Elias Arellano, Kassandra Pulido, Tyler Torres, Dominic Chau-Zanetti, Natasha N. Quailes, Andres Suarez Parraga

School of Medicine Publications

Introduction

Diabetes mellitus (DM) encompasses metabolic disorders characterized by elevated blood sugar. This study aimed to evaluate the prevalence and associated metrics of DM in the Rio Grande Valley (RGV), a low-income and medically underserved region in the United States, and compare these metrics to the national averages from 2012 to 2022.

Methods

A retrospective cross-sectional analysis was conducted using publicly accessible data from the Centers for Medicare and Medicaid Services (CMS). Metrics analyzed included DM prevalence, average principal cost, rates of emergency department visits, hospitalizations, screenings, and prevalence of obesity. Data from the RGV counties were compared to national …

Neuroprotective Effects Of Magnesium: Implications For Neuroinflammation And Cognitive Decline, Veer Patel, Nuraly S. Akimbekov, William B. Grant, Carolyn Dean, Xiaoqian Fang, Mohammed S. Razzaque

School of Medicine Publications

Neurodegenerative diseases, which are characterized by progressive neuronal loss and cognitive decline, are a significant concern for the aging population. Neuroinflammation, a shared characteristic of these diseases, is implicated in their pathogenesis. This article briefly summarizes the role of magnesium, an essential mineral involved in numerous enzymatic reactions and critical for neuronal bioactivity, in the context of neuroinflammation and cognitive decline. The potential neuroprotective effects of magnesium, including the mechanisms of neuroprotection by magnesium through maintaining neuronal ion homeostasis, reducing inflammation, and preventing excitotoxicity, are also described. Additionally, we discuss the impact of inadequate magnesium on neuroinflammation and its potential …

Kclc’S The Tower Launches ‘The Lion’S Den’, Josh Calloni

Lindenlink (2012- )

No abstract provided.

Fall 2024 Panel And Networking Reception, Nyls Family And Matrimonial Society

Student Organizations

September 24, 2024

Brief Of Criminal Law Scholars As Amici Curiae In Support Of Petitioner, Ira P. Robbins

Amicus Briefs & Court Filings

Amici are law professors who teach and research criminal law and procedure. They have no personal interests in this case. Their sole interest is in the protection and preservation of the constitutional rights of criminal defendants.

Cd103+ Cdc1 Dendritic Cell Vaccine Therapy For Osteosarcoma Lung Metastases, Yuanzheng Yang, Yifan Zhou, Jian Wang, You Zhou, Stephanie S Watowich

Faculty, Staff and Student Publications

Background: We generated a CD103+DC vaccine using K7M3 OS cell lysates (cDCV) and investigated its ability to induce regression of primary tumors, established lung metastases, and a systemic immune response. Methods: A bilateral tumor model was used to assess cDCV therapy efficacy and systemic immunity induction. K7M3 cells were injected into mice bilaterally. Right-sided tumors received PBS (control) or cDCV. Left-sided tumors were untreated. Tumor growth was compared between the vaccine-treated and untreated tumor on the contralateral side and compared to the control group. The immune cell profiles of the tumors, and tumor-draining lymph nodes (TdLNs) and spleen were evaluated. …

In Vivo Crispr Screens Identify Mga As An Immunotherapy Target In Triple-Negative Breast Cancer, Xu Feng, Chang Yang, Yuanjian Huang, Dan Su, Chao Wang, Ling Yin, Siting Li, Zhen Chen, Dandan Zhu, Shimin Wang, Shengzhe Zhang, Jie Zhang, Huimin Zhang, Litong Nie, Min Huang, Jae-Il Park, Traver Hart, Dadi Jiang, Kuirong Jiang, Junjie Chen

Faculty, Staff and Student Publications

Understanding the mechanisms underlying immune evasion is crucial for developing novel anticancer modalities. To systematically uncover tumor-intrinsic genetic modulators involved in immune escape in tumor microenvironment, we performed genome-scale in vivo CRISPR screens in two syngeneic models and later expanded up to seven syngeneic models with a focused validation library. These data help us better understand tumor immune evasion and pave the way for developing effective therapeutics. Importantly, we uncovered that Mga depletion elicited an antitumor immune response and inhibited tumor growth in triple-negative breast cancer. Our findings suggest that Mga may play a role in modulating the tumor immune …

Stimulation Of An Entorhinal-Hippocampal Extinction Circuit Facilitates Fear Extinction In A Post-Traumatic Stress Disorder Model, Ze-Jie Lin, Xue Gu, Wan-Kun Gong, Mo Wang, Yan-Jiao Wu, Xin-Rong Wu, Michael X Zhu, Lu-Yang Wang, Quanying Liu, Ti-Fei Yuan, Wei-Guang Li, Tian-Le Xu

Faculty, Staff and Student Publications

Effective psychotherapy of post-traumatic stress disorder (PTSD) remains challenging owing to the fragile nature of fear extinction, for which the ventral hippocampal CA1 (vCA1) region is considered as a central hub. However, neither the core pathway nor the cellular mechanisms involved in implementing extinction are known. Here, we unveil a direct pathway, where layer 2a fan cells in the lateral entorhinal cortex (LEC) target parvalbumin-expressing interneurons (PV-INs) in the vCA1 region to propel low-gamma-band synchronization of the LEC-vCA1 activity during extinction learning. Bidirectional manipulations of either hippocampal PV-INs or LEC fan cells sufficed for fear extinction. Gamma entrainment of vCA1 …

Predictors Of Transition From Child And Adolescent Bipolar Not Otherwise Specified To Bipolar I Disorder, A Longitudinal 3.9-Year Study., María Ribeiro-Fernández, Azucena Díez-Suárez, Kiki D Chang, Cesar A Soutullo

Faculty, Staff and Student Publications

Background: Children and adolescents with subthreshold manic symptoms not meeting full DSM criteria for bipolar I or II disorder (BP-I or BP-II) are classified as unspecified bipolar disorder (formerly bipolar not otherwise specified: BP-NOS). Factors associated with transition from BP-II or NOS to BP-I may predict the progression of the disorder. Our objective is to analyze factors associated with transition to BP-I in a Spanish sample of youth with BP-NOS or BP-II.

Methods: We included all youth diagnosed with BP before 18 years of age presenting to our clinic (October 1999-December 2014). We assessed clinical factors that may predict transition …

Experiences Of Integrating Social Prescribing Link Workers Into Primary Care In England: Bolting On, Fitting In Or Belonging, Stephanie Tierney, Debra Westlake, Geoff Wong, Amadea Turk, Steven Markham, Jordan Gorenberg, Joanne Reeve, Caroline Mitchell, Kerryn Husk, Sabi Redwood, Catherine Pope, Beccy Baird, Kamal R. Mahtani

Peninsula Medical School

Background: Following the 2019 NHS Long-Term Plan, link workers (LWs) have been employedacross primary care in England to deliver social prescribing (SP).Aim: To understand and explain how the LW role is being implemented in primary care in England.Design and setting: Realist evaluation undertaken in England.Method: Focused ethnographies around seven LWs from different parts of England. As part of this,we interviewed 61 patients and 93 professionals from healthcare and the voluntary, community andsocial enterprise (VCSE) sector. We reinterviewed 41 patients, seven LWs and a LW manager 9-12months after their first interview.Results: We developed four concepts around how LWs are integrated (or …

How Valid Is The Lca Data For Composite Materials? ~ A Data Quality Assessment Approach, Badr Moutik, John Summerscales, Jasper Graham-Jones, Richard Pemberton

School of Engineering, Computing and Mathematics

- Sustainability as a priority: Central to the growth of the composite industry.- Regulatory impact: Increasing regulations include sustainability mandates for composite products.- Role of LCA: Life cycle assessment is critical for evaluating environmental sustainability in material selection and manufacturing. • Growing research: LCA studies on composites have surged, showing an annual growth rate of over 20%. • Variability and uncertainty concerns: Significant discrepancies in LCA data per unit weight of composite materials highlight risks of inaccuracies.

Prevalence And Progression Of Albuminuria After Smoking Cessation: A Uk Biobank Cohort Study, Debasish Kar

Peninsula Medical School

No abstract provided.

Knowledge And Confidence Of Obstetrics And Gynecology Residents In The Evaluation And Management Of Heavy Menstrual Bleeding Due To Inherited Bleeding Disorders., Patricia S. Huguelet, Irmel A. Ayala, Laurel Beaty, Christina Bemrich-Stolz, Claudia Borzutzky, Tazim Dowlut-Mcelroy, Sweta Gupta, Kendra Hutchens, Corinna L. Schultz, Lakshmi Srivaths, Maria C. Velez, Neeraja Swaminathan

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Heavy menstrual bleeding (HMB) is common, and 20-30% of patients presenting with HMB are diagnosed with an inherited bleeding disorder (IBD). Despite the frequent association of HMB with bleeding disorders, specific learning objectives on this topic are lacking for Obstetrics and Gynecology (OBGYN) residents.

OBJECTIVE: We sought to determine the exposure of OBGYN residents to didactics, clinical training, and confidence in evaluation and management of patients with HMB due to IBDs.

METHODS: Prospective survey of OBGYN residents through email solicitation. Residents were invited to complete an anonymous 26-item survey, querying residents' confidence in evaluation and management of HMB in …

Codesigning A Clinical Prediction Model For Aboriginal Perinatal Mental Health Using Glassbox Ai And Aboriginal Wisdom And Lived Experience, Guanjin Wang, Hachem Bennamoun, Wai Hang Kwok, Rhonda Marriott, Roz Walker, Jayne Kotz

Research outputs 2022 to 2026

Perinatal mental health is vital for mothers, infants, and families. Aboriginal mothers, despite their strengths, face greater mental health disparities due to colonisation and trauma. Traditional screening methods lack cultural sensitivity. The Baby Coming You Ready (BCYR) program offers a culturally sensitive assessment with promising pilot results. To support health professionals, an AI solution using the Explainable Boosting Machine (EBM) is proposed, trained with Aboriginal lived experiences. This model identifies maternal protective and risk factors, offering interpretable predictions for holistic culturally sensitive care.