Digital Commons Network^™

Inorganic Pyrophosphate Plasma Levels In Patients With Ggcx-Associated Pxe-Like Phenotypes, Qiaoli Li, Catherine Troutman, Mary Peckiconis, Tamara Wurst, Sharon Terry

Department of Biochemistry and Molecular Biology Faculty Papers

ntroduction: Pseudoxanthoma elasticum (PXE) is an autosomal recessive ectopic calcification disorder clinically affecting the skin, eyes, and vascular system. Most cases of PXE are caused by inactivating pathogenic variants in the ABCC6 gene encoding a hepatic transmembrane efflux transporter, which facilitates the extracellular release of ATP, the precursor of inorganic pyrophosphate (PPi), a potent endogenous inhibitor of calcification. Pathogenic variants in GGCX, encoding γ-glutamyl carboxylase required for activation of vitamin K-dependent coagulation factors as well as matrix Gla protein (MGP) and Gla-rich protein (GRP), two inhibitors of ectopic calcification, have also been reported to cause cutaneous changes like those seen …

An Archaeological And Archaeoseismological Perspective On Earthquakes In The Coastal Cities Of Western Anatolia In The 3rd Millennium Bce: Settlement Abandonment And Changes In Social Structures, Ümi̇t Gündoğan

Turkish Journal of Earth Sciences

This study investigates the impact of the earthquakes that occurred in the first half of the 3rd millennium BCE on Western Anatolian settlements, aiming to determine the dates of the earthquakes that happened during the prehistoric period using the earthquake layers of the settlements and associated C14 data. The focus of the paper is the investigation of the effects of two earthquakes that occurred in the region during the first half of the 3rd millennium BCE on the settlements of the region. The first earthquake occurred around 2800 BCE and damaged settlements in the area of İzmir. Evidence of this …

Sequence Stratigraphy And Hydrocarbon Potential Of The Paleozoic Successions On The Arabian Platform And Southeast Türkiye, Muhi̇tti̇n Şenalp, Sema Teti̇ker

Turkish Journal of Earth Sciences

In 1989, the first prolific hydrocarbon reservoirs were discovered by Saudi Aramco in the highly porous and permeable friable continental sandstones (Unayzah reservoirs) and shallow marine carbonates (Khuff reservoirs) of the Paleozoic successions in south of Riyadh, Central Arabia. These successions were strongly affected by tectonic movements (Caledonian and Hercynian orogenesis) and Early and Late Paleozoic Gondwana glaciations. Therefore, some sections were fully eroded or significantly reduced in their thickness. The sequence stratigraphic interpretation of the Paleozoic successions helped to understand the depositional environments and regional distribution of the source, reservoir and cap rock facies in an improved palynologic studies. …

Top To Bottom Interactive Velocity Analysis Using Travel-Time Ellipses And First Break Times From Walkaway Vertical Seismic Profiling Data: A Synthetic Study, Cemal Erdemi̇r

Turkish Journal of Earth Sciences

An interactive velocity analysis method is introduced in this paper and its efficacy is tested on various walkaway vertical seismic profile (WVSP) modeled data sets. In WVSP surveys, interval velocity profiles are determined fairly accurately along the VSP borehole using first break travel time picks from the zero-offset VSP (ZVSP) data. However the accuracy of these vertical velocities fade away quickly as the source distance (offset) from the VSP borehole increases due to possible horizontal changes in the geology or dips of the horizons. If the layer boundaries are not known, a simple approach type of ray tracing using horizontally …

Coral Reef Protection Is Fundamental To Human Rights, Emma F. Camp, Irus Braverman, Genevieve Wilkinson, Christian R. Voolstra

Journal Articles

The intensifying loss of coral reefs from global climate change and local stressors has seen international commitments targeted at conservation and repair, for example the Kunming–Montreal Global Biodiversity Framework. Fulfilling these targets requires decisions to be made on where, when, and how to act, ultimately dictating where limited resources will be deployed. Every choice on action or inaction toward our ocean has direct and indivisible consequences not only for the health of marine ecosystems but also for the health of humans, particularly those who directly depend on marine habitats, both culturally and economically. The well-being of the environment, humans, and …

Doctors’ Day Celebration And Integration Of Homoeopathy With Mainstream Healthcare, Subhash Kaushik

Indian Journal of Research in Homoeopathy

National Doctors' Day is observed in India on July 1st to commemorate the birth and death anniversary of Bharat Ratna Awardee, Dr. Bidhan Chandra Roy, a distinguished physician, freedom fighter, and former Chief Minister of West Bengal, India . This year’s theme for National Doctors' Day was, "Healing Hands, Caring Hearts," highlights the commitment, compassion, and empathy that doctors bring to their practice, underscoring their vital role in saving and enhancing lives. Practised for over a century in India, Homoeopathy has long been known for its role in enhancing the lives of people, in terms of gentle, holistic healing and …

Homoeopathy In Bipolar Affective Disorder: A Review Of Research Evidence, Deepthi Gilla, K.P. Deepak, Sreeja Kr Nair, K.C. Muraleedharan

Indian Journal of Research in Homoeopathy

Background: Bipolar affective disorder (BPAD) is an episodic, chronic psychiatric disorder characterized by fluctuations in mood state and energy. It affects more than 1% of the world’s population. BPAD causes cognitive and functional impairment and raised mortality, particularly death by suicide. At present, although alternative therapies are not the first-line treatment of mood disorders, there is emerging evidence showing that such treatments are effective. Objective: The objective of this review is to synthesize existing research evidence and literature to determine the usefulness of homoeopathic medicines in the management of manic and depressive episodes of BPAD. Materials and Methods: Two authors …

Stability Study Of Homoeopathically Potentised Arsenicum Album In Hydrolytic Amber Glass Class Ii And High-Density Polyethylene Terephthalate Over Twelve Months, Marcia Pietroluongo, Thiago Frances Giuimarães, Thais De Barros Fernandes, Ana Paula Dos Santos Matos, Fortune Homsani, Adriana Passos Oliveira, Alessandra Lifsitch Viçosa, Carla Holandino Quaresma

Indian Journal of Research in Homoeopathy

Background: The Brazilian Homoeopathic Pharmacopoeia (BHP) recommends using glass amber Type I, II, or III as a primary container for storing homoeopathic liquid medicines. Although the glass has advantages, there are some disadvantages, such as fragility, weight, and the presence of silicate particles, which have been described as critical components involved with the generation of silicon microparticles detected in homoeopathic solutions. Objectives: The present study aimed to investigate the stability of hydroalcoholic solutions of Arsenicum album dynamised in two different vials: class II hydrolytic amber glass and amber high-density polyethylene terephthalate (PET). Materials and Methods: Two potencies of the Arsenicum …

A Pragmatic, Open-Label Study To Evaluate The Response Of Homoeopathic Treatment In Vitiligo, Divya Taneja, Renu Mittal, R. Bhuvaneswari, Akshaya Kumar Prusty, P. S. Chakraborty, Bharti Wadhwa, Lipipushpa Debata, Ashish P. Shivadikar, Nidhi Mahajan, Vaishali Shinde, Uttam Singh, Siva Prasad Goli, Renu Bala, Pooja Kumari, Anil Khurana, Raj Kumar Manchanda

Indian Journal of Research in Homoeopathy

Background: Homoeopathy is commonly used by patients suffering from vitiligo. The treatment response needs to be assessed on standardised scales in pragmatic settings. Objective: The study aimed to evaluate response to homoeopathic treatment in vitiligo severity and quality of life using the vitiligo area scoring index (VASI) score, Vitiligo European Task Force (VETF) score and dermatological life quality index (DLQI) score. Materials and Methods: This study was undertaken in dermatology outpatient departments at 11 research institutes of the Central Council for Research in Homoeopathy. Participants, in the age group 18–60 years, any gender, presenting with at least one vitiligo skin …

Polycystic Ovarian Syndrome And Homoeopathic Management: A Case Series, Padmalaya Rath, Priya Gautam, Amiyananda Dev Goswami, Shib Narayan Jana

Indian Journal of Research in Homoeopathy

Introduction: Polycystic ovary syndrome (PCOS) is a disorder of chronically abnormal ovarian function and hyperandrogenism (abnormally elevated androgen levels). It is manifested by irregular menstrual cycles, polycystic ovaries, acne, excess unwanted hair growth, obesity, etc. PCOS can affect a female’s fertility. The global prevalence of PCOS varies from 5% to 18%, with an average prevalence of 276·4 cases per 100,000 people in Europe. The prevalence of PCOS in India ranges from 3.7 to 22.5% depending on the population studied. Case Summary: This is a case series of five patients suffering from PCOS, assessed on the basis of intermenstrual duration, acne …

Ichthyosis Vulgaris Successfully Treated With Individualised Homoeopathic Medicine Dulcamara 200c – An Evidence-Based Case Report, Lalith Singh, Raja Manoharan, Sukanya Mitra, Rajib Purkait

Indian Journal of Research in Homoeopathy

Introduction: Ichthyosis vulgaris (IV) is a hereditary condition that often manifests in infancy but can also exist from birth. It is a recalcitrant disorder relapses often and even shows the least response to various therapeutic options. Extensive literature review have revealed a dearth of appropriate evidence-based documentation on treatment of ichthyosis in Homoeopathy. Case Summary: This is a case of IV in a 20-year-old male, manifested as widespread scaling and itching since childhood. Following homoeopathic principles, Dulcamara 200C was prescribed. Outcome related to impact on daily living (ORIDL) scale was used to evaluate the patient-reported outcome measure subjectively, and the …

Research Highlights, Annie Valentina

Indian Journal of Research in Homoeopathy

Research Highlights

Minutes, Faculty Affairs Committee Meeting, Friday, September 27, 2024, Faculty Affairs Committee

Faculty Affairs Committee Minutes

No abstract provided.

Integrating Data-Driven And Mechanism-Driven Modeling In Drug Discovery And Hepatotoxicity Evaluation, Xuelian Jia

Theses and Dissertations

The pharmacological activities and hepatotoxicity significantly influence the success or failure of new drugs during drug discovery and development. Traditional experimental methods, such as animal models, are costly and time-consuming for chemical testing. There is a great need to develop in vitro and computational modeling to help identify the pharmacological activities and hepatotoxicity potential in the early stage of drug discovery and safety evaluation. In this dissertation, new computational models and associated modeling frameworks were described for predicting the biological profile and hepatotoxicity of chemicals. Firstly, a novel data mining and Quantitative Structure-Activity Relationship (QSAR) workflow was developed to construct …

Mathematics Group Earns National Award During Inaugural Year, Marvis Herring

University of Mississippi News

OXFORD, Miss. – The Association for Women in Mathematics has honored the University of Mississippi with its 2024 Student Chapter Award for Community Outreach.

September 27, 2024 Minutes, Swosu Faculty Senate

Faculty Senate Minutes

No abstract provided.

Agreement On Emergency Liquidity Assistance: 27 September 2024, European Central Bank

Documents

No abstract provided.

Ao Spine-Dgou Osteoporotic Fracture Classification System: Internal Validation By The Ao Spine Knowledge Forum Trauma, Julian Scherer, Andrei Joaquim, Alex Vaccaro, Rishi Kanna, Mohammad El-Sharkawi, Masahiko Takahata, Mohamed M. Aly, Gaston Camino-Willhuber, Ulrich Spiegl, Cumhur Oner, Jose A. Canseco, Ratko Yurac, Lorin Michael Benneker, Eugen Cezar Popescu, Richard Bransford, Harvinder Cezar Chhabra, Frank Kandziora, Marko H. Neva, Klaus John Schnake

Rothman Institute Papers

Study Design: Cross-sectional survey.

Objectives: Injury classifications are important tools to identify fracture patterns, guide treatment-decisions and aid to identify optimal treatment plans. The AO Spine-DGOU Osteoporotic Fracture (OF) classification system was developed, and the aim of this study was to assess the reliability of this new classification system.

Methods: 23 Members of the AO Spine Knowledge Forum Trauma participated in the validation process. Participants were asked to rate 33 cases according to the OF classification at 2 time points, 4 weeks apart (assessment 1 and 2). The kappa statistic(κ) was calculated to assess inter-observer reliability and intra-rater reproducibility. The …

Longest Table Event To Promote Community And Conversation, Marvis Herring

University of Mississippi News

OXFORD, Miss. – Whether it's family dinner, brunch with friends or a work potluck, shared meals build a sense of community, and those dining experiences often spur thought-provoking conversations.

Noninvasive Multi-Cancer Detection Using Blood-Based Cell-Free Micrornas, Jason Zhang, Hallgeir Rui, Hai Hu

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Patients diagnosed with early-stage cancers have a substantially higher chance of survival than those with late-stage diseases. However, the option for early cancer screening is limited, with most cancer types lacking an effective screening tool. Here we report a miRNA-based blood test for multi-cancer early detection based on examination of serum microRNA microarray data from cancer patients and controls. First, a large multi-cancer training set that included 1,408 patients across 7 cancer types and 1,408 age- and gender-matched non-cancer controls was used to develop a 4-microRNA diagnostic model using 10-fold cross-validation. In three independent validation sets comprising a total of …

Fort Hays State University Tiger Weekly, September 27, 2024, University Relations

Tiger Weekly Newsletters

No abstract provided.

The Beacon, September 27, 2024, Beacon Staff

The Beacon, 2024-2025

Northwestern graduates return as RDs; 'Fowl' Play in Orange City Legislature; Pep band provides energy for fans; A cinematic journey of defying the odds; Katy Perry's underwhelming return; A short story of unexpected love; The importance of Suicide Prevention Month; Continuing leadership at NW as RDs; Ngages & NEDTalks take political twist; Egg-stra! Egg-stra!; Why are we so Divided?; Northwestern's Underrated Study Spot; Raider soccer faces changes to rosters; Men's tennis looks to dominate season; Sports betting is a campus craze across America; SAC hosts glow in the dark minigolf; Former President has life threatened;

Revealing Ultra-High-Energy Gamma-Ray Emission From The Ehwc J1825-134 Region With Hawc, Dezhi Huang, Dezhi Huang, Hazal Goksu, Hazal Goksu, A. Albert, R. Alfaro, C. Alvarez, A. Andrés, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, T. Capistrán, Y. Cárcamo, A. Carramiñana, F. Carreón, U. Cotti, J. Cotzomi, S. Coutino De Leon, E. De La Fuente, D. Depaoli, C. De Leon, R. Diaz Hernandez, J. C. Diaz-Velez, B. L. Dingus, M. Durocher, M. A. Duvernois, K. Engel, C. Espinoza, K. L. Fan, K. Fang, N. I. Fraija, J. A. Garcia-Gonzalez, F. Garfias, H. Goksu, M. M. Gonzalez, J. A. Goodman, S. Groetsch, J. P. Harding, S. Hernandez, I. Herzog, J. Hinton, D. Huang, F. Hueyotl-Zahuantitla, P. Huntemeyer, A. Iriarte, V. Joshi, S. Kaufmann, D. Kieda, A. Lara, J. Lee, W. H. Lee, H. Leon Vargas, J. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, J. Martinez-Castro, J. A. J. Matthews, P. Miranda-Romagnoli, J. Montes, J. A. Morales-Soto, M. Mostafa, L. Nellen, M. U. Nisa, R. Noriega-Papaqui, L. Olivera-Nieto, N. Omodei, Y. Perez Araujo, E. G. Perez-Perez, A. Pratts, C. D. Rho, D. Rosa-Gonzalez, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, A. Sandoval, M. Schneider, G. Schwefer, J. Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Urena-Mena, L. Villasenor, Xiaojie Wang, I. J. Watson, F. Werner, K. Whitaker, E. Willox, H. Wu, H. Zhou

Physics Faculty Research & Creative Works

Located in the southern field of view of the High-Altitude Water Cherenkov (HAWC) observatory, the eHWC J1825-134 region is one of the most complicated gamma-ray emission sites on the galactic plane. The region contains a few PeVatron candidates that can accelerate particles up to PeV energies. Disentangling the overlapping gamma-ray emission and associating it with accelerators is crucial to understand the mechanism of cosmic-ray acceleration and gamma-ray production near the accelerators. In this talk, I will present each of the gamma-ray sources resolved in this region using 1910 days of HAWC data, including their spectra. Also, we have studied their …

Fatigue-Resistant Mechanoresponsive Color-Changing Hydrogels For Vision-Based Tactile Robots, Jiabin Liu, Wei Li, Yu She, Sean Blanchard, Shaoting Lin

School of Industrial Engineering Faculty Publications

Mechanoresponsive color-changing materials that can reversibly and resiliently change color in response to mechanical deformation are highly desirable for diverse modern technologies in optics, sensors, and robots; however, such materials are rarely achieved. Here, a fatigue-resistant mechanoresponsive color-changing hydrogel (FMCH) is reported that exhibits reversible, resilient, and predictable color changes under mechanical stress. At its undeformed state, the FMCH remains dark under a circular polariscope; upon uniaxial stretching of up to six times its initial length, it gradually shifts its color from black, to gray, yellow, and purple. Unlike traditional mechanoresponsive color-changing materials, FMCH maintains its performance across various strain …

Selected U.S. Government Statistical Agencies And Their Data, Bert Chapman

Libraries Faculty and Staff Presentations

Provides introductory and detailed overview of U.S. Government agencies statistics. Includes examples of how an individual U.S. law authorizes government agencies to compile statistics for particular congressional committees and the general public. Statistics cover topics such as demography, defense, foreign assistance, economic growth, criminal justice, energy, Social Security, and Medicare.

Genomic And Socioeconomic Determinants Of Racial Disparities In Breast Cancer Survival: Insights From The All Of Us Program, Nubaira Rizvi, Hui Lyu, Leah Vaidya, Xiao Cheng Wu, Lucio Miele, Qingzhao Yu

School of Public Health Faculty Publications

Background: Breast cancer outcomes are worse among Black women in the U.S. compared to White women. While extensive research has focused on risk factors contributing to breast cancer; the role of genomic elements in health disparities between these racial groups remains unclear. This study aims to identify genomic variants and socioeconomic status (SES) determinants influencing racial disparities in breast cancer survival through multiple mediation analyses. Methods: Our investigation is based on the NIH-supported All of Us (AoU) program and analyzes 7452 female participants with malignant tumors of breast, including 5073 with genomic data. A log-rank test reveals significant racial differences …

Umn Morris Choirs Participate Virtually In International Choral Festival, Communications And Marketing

Campus News Archive

No abstract provided.

An Edge Platform Streamlining Connectivity Between Modern Edge Devices And Cloud, Anderson Carvalho

Theses

The numerous uses of cloud, fog, and edge computing in a variety of industries are thoroughly examined in this thesis, with a special emphasis on smart factories, smart cities, and smart agriculture. It starts with an introduction to cloud computing, going over its history, importance in contemporary digital infrastructures, and related security concerns. It emphasizes the value of cloud computing for processing and storing data while addressing issues like guaranteeing low latency applications and possible improvements from container technologies. The conversation then shifts to fog computing, going over its history, designs, and uses. It focuses on how fog computing might …

Information-Theoretic Modeling Of Categorical Spatiotemporal Gis Data, David Percy, Martin Zwick

Geology Faculty Publications and Presentations

An information-theoretic data mining method is employed to analyze categorical spatiotemporal Geographic Information System land use data. Reconstructability Analysis (RA) is a maximum-entropy-based data modeling methodology that works exclusively with discrete data such as those in the National Land Cover Database (NLCD). The NLCD is organized into a spatial (raster) grid and data are available in a consistent format for every five years from 2001 to 2021. An NLCD tool reports how much change occurred for each category of land use; for the study area examined, the most dynamic class is Evergreen Forest (EFO), so the presence or absence of …

Prompt And Accurate Grb Source Localization Aboard The Advanced Particle Astrophysics Telescope (Apt) And Its Antarctic Demonstrator (Adapt), Ye Htet, Marion Sudvarg, Jeremy Buhler, Roger Chamberlain, Wenlei Chen, James Buckley, Roger D. Chamberlain, Corrado Altomare, Matthew Andrew, Blake Bal, Richard G. Bose, Dana Braun, Eric Burns, Michael L. Cherry, Leonardo Di Venere, Jeffrey Dumonthier, Manel Errando, Stefan Funk

Computer Science Faculty Research & Creative Works

We characterize the performance of our computational pipeline for real-time gamma-ray burst (GRB) detection and localization aboard the Advanced Particle-astrophysics Telescope (APT) – a space-based observatory for MeV to TeV gamma-ray astronomy – and its smaller, balloon-borne prototype, the Antarctic Demonstrator for APT (ADAPT), whose scientific focus will be the detection of MeV transients. These instruments observe scintillation light from multiple Compton scattering and photoabsorption of gamma-ray photons across a series of CsI detector layers. We infer the incident angle of each photon's first scattering to localize its source direction to a Compton ring about the vector defined by its …