Digital Commons Network^™

Il-8, Tnf-Α, And Il-17 In The Development Of Erosive Esophagitis And Symptom Perception In Gastroesophageal Reflux Disease (Gerd), Michael Austin Pradipta Lusida, Isna Mahmudah, Hafeza Aftab, Ratha-Korn Vilaichone, Yoshio Yamaoka, Hoda M Malaty, Muhammad Miftahussurur

Faculty, Staff and Students Publications

Background: The diverse clinical characteristics of erosive esophagitis (EE) and symptom perception in patients with gastroesophageal reflux disease (GERD) remain a major challenge in understanding their underlying pathogenesis. This study aimed to investigate the association between the levels of IL-8, TNF-α, and IL-17 in serum and the presence of erosive esophagitis and symptoms related to GERD. Method: We enrolled 65 subjects presenting with GERD symptoms. Based on the findings of upper endoscopy, the subjects were categorized into two groups: (1) erosive esophagitis (EE LA grades B-D) and (2) non-erosive esophagitis (normal-EE LA grade A). Symptom perception was assessed via GERD …

Table Of Contents

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Table of contents

Longitudinal Relations Between Parenting Practices And Prosocial Behaviors In Recent Immigrant Latino/A Adolescents: Familism Values And Ethnic Identity As Mediators, Sahitya Maiya, Gustavo Carlo, Alexandra N. Davis, Seth J. Schwartz, Jennifer B. Unger, Byron L. Zamboanga, Lourdes Baezconde-Garbanati, Daniel W. Soto, Elma I. Lorenzo-Blanco

Psychological Science Faculty Publications and Presentations

Introduction:

The present study investigated the mediating roles of familism values and ethnic identity in longitudinal associations between recent immigrant U.S. Latino/a adolescents' reports of their parents' (i.e., mothers' and fathers') use of social and material rewards and prosocial behaviors.

Methods:

Participants included 302 recent immigrant U.S. Latino/a adolescents (M age = 14.5 years at Time 1, range = 13–17 years, 53% male) recruited from Los Angeles and Miami. Participants self-reported on their perceptions of parents' use of social and material rewards (Time 1), familism values (Time 3), ethnic identity (Time 5), and multiple types of prosocial behaviors (Time …

Negative Effect Of Treatment With Mglur5 Negative Allosteric Modulator Afq056 On Blood Biomarkers In Young Individuals With Fragile X Syndrome, Dragana Protic, Stephanie Morris, Et Al.

2020-Current year OA Pubs

BACKGROUND: Fragile X syndrome, with an approximate incidence rate of 1 in 4000 males to 1 in 8000 females, is the most prevalent genetic cause of heritable intellectual disability and the most common monogenic cause of autism spectrum disorder. The full mutation of the Fragile X Messenger Ribonucleoprotein-1 gene, characterized by an expansion of CGG trinucleotide repeats (>200 CGG repeats), leads to fragile X syndrome. Currently, there are no targeted treatments available for fragile X syndrome. In a recent large multi-site trial, FXLEARN, the effects of the mGluR5 negative allosteric modulator, AFQ056 (mavoglurant), were investigated, but did not show …

Effects Of White Matter Hyperintensity Burden On Functional Outcome After Mild Versus Moderate-To-Severe Ischemic Stroke, Dong-Seok Gwak, Wi-Sun Ryu, Dawid Schellingerhout, Jinyong Chung, Hang-Rai Kim, Beom Joon Kim, Keun-Sik Hong, Jong-Moo Park, Man-Seok Park, Kang-Ho Choi, Tai Hwan Park, Kyungbok Lee, Sang-Soon Park, Kyusik Kang, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi-Sun Oh, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Jun Lee, Moon-Ku Han, Ji Sung Lee, Hee-Joon Bae, Dong-Eog Kim

Faculty, Staff and Student Publications

It is uncertain whether the prognostic power of white matter hyperintensity (WMH) on post-stroke outcomes is modulated as a function of initial neurological severity, a critical determinant of outcome after stroke. This multi-center MRI study tested if higher WMH quintiles were associated with 3-month poor functional outcome (modified Rankin Scale ≥ 3) for mild versus moderate-to-severe ischemic stroke. Mild and moderate-to-severe stroke were defined as admission National Institute of Health Stroke Scale scores of 1-4 and ≥ 5, respectively. Mean age of the enrolled patients (n = 8918) was 67.2 ± 12.6 years and 60.1% male. The association between WMH …

Cover And Forewords, Steven M. Schnell

The Geographical Bulletin

Cover and Forewords

Volume 55-2 Complete Issue, Steven M. Schnell

The Geographical Bulletin

Volume 55-2 Complete Issue

An Introduction To The Geography Of Tourism By Velvet Nelson, William C. Terry

The Geographical Bulletin

Geographers specializing in the study of tourism have long complained about the marginalization of the sub-discipline within the wider scope of geography. Those of us who teach tourism geography recognize tourism as an inherently geographical topic ripe for critical investigation in classrooms. Yet despite the obvious appeal, there have been few texts that attempt a comprehensive overview of tourism geography and none geared directly at an undergraduate audience while also striking the right tone and level of engagement required to fulfill the task. I have personally heretofore eschewed the use of textbooks in teaching tourism geography in part because I …

Improved Monitoring Of Forest Disturbance And Succession Using An Optimized Satellite Image Index, Matthew Klotzbach, Jonathan Thayn

The Geographical Bulletin

Landscape- to continental-scale studies of forest disturbance and recovery typically rely on satellite image-based indices of vegetation condition. A recently proposed disturbance index that accentuates patches of disturbed forest has been used to detect fire and insect defoliation scars, but until now it has not been used to assess recovery over time. We used a weighted version of the index to emphasize canopy differences caused by fire while minimizing other differences that may exist in the imagery to monitor succession following the 1988 fires in Yellowstone National Park. Spectral estimates of moisture levels were the most important difference between burned …

Interview: Kimi Eisele, Steven M. Schnell

The Geographical Bulletin

Kimi Eisele1 is a writer, dancer/choreographer, performer, director, visual artist, and educator based in Tucson, Arizona. Drawing on her MA in geography and a long-standing interest in place and space, she creates works that engage local landscapes, including ecosystems, political systems, and human communities. In 1997, while a graduate student in geography at the University of Arizona, she founded you are here: the journal of creative geography, an interdisciplinary outlet for place-based writing and art, a publication that is still going strong.

Championing The City Motto: An Analysis Of Edmonton’S Un/Official Slogan, Nathan Bunio, Elvin Wyly

The Geographical Bulletin

This article examines urban slogans using a case study of Edmonton’s unofficial motto; “City of Champions.” We will be exploring the decision-making process regarding the city slogan, specifically who creates and adopts a city slogan, and what the relationship is between a city’s slogan and its residents. The analysis focuses on events in 2003, when the Edmonton Economic Development Corporation suggested creating a new slogan for the City, prompting a debate over whether to keep or discard the old slogan: “City of Champions.” We carried out a historical case study, using newspaper articles, blogs, and city documents, to gauge public …

Spatial Crime Displacement On Chicago’S South Side, David Melsness, Ryan Weichelt

The Geographical Bulletin

This research examines the effects of population displacement after the demolition of the Robert Taylor Homes (in Chicago’s 2nd Police District) on crime in neighboring police districts that serve impoverished, racially segregated, high-crime neighborhoods where many former residents relocated. The objective is to analyze possible relationships between the demolition of the housing project and crime trends of murder, robbery, and total reported index crime in surrounding police districts and police beats through the use of hotspot analysis.

Dr. Ernest Patti, Mark Naison

Bronx African American History Project (BAAHP)

Summarized by Lauren Payne

Dr. Ernest Patti, an ER attending physician at St. Barnabas Hospital in the Bronx, shared his experiences during the COVID-19 pandemic. He detailed the hospital's transition from a Level 1 to a Level 2 trauma center due to resource constraints. Patty described the increased patient volume, with over 100,000 patients annually, and the emotional toll of treating critically ill COVID-19 patients without visitors. He highlighted the community's support, including food donations and personal protective equipment. Patti also mentioned the loss of colleagues and the importance of teamwork in managing the pandemic.

Unveiling The Risks Of Speeding Behavior By Investigating The Dynamics Of Driver Injury Severity Through Advanced Analytics., Mouyid Islam, Parisa Hosseini, Anahita Kakhani, Mohammad Jalayer, Deep Patel

Henry M. Rowan College of Engineering Departmental Research

Single-vehicle crashes, particularly those caused by speeding, result in a disproportionately high number of fatalities and serious injuries compared to other types of crashes involving passenger vehicles. This study aims to identify factors that contribute to driver injury severity in single-vehicle crashes using machine learning models and advanced econometric models, namely mixed logit with heterogeneity in means and variances. National Crash data from the Crash Report Sampling System (CRSS) managed by the National Highway Traffic Safety Administration (NHTSA) between 2016 and 2018 were utilized for this study. XGBoost and Random Forest models were employed to identify the most influential variables …

Argentina: Crisis, Conurbano Y Literatura. Cuatro Novelas Del Primer Decenio Del Siglo Veintiuno Y Su Relación Con La Crisis Y El Espacio Bonaerense, Luciano Martínez

Spanish Faculty Works

Este artículo analiza cuatro novelas argentinas contemporáneas: Turdera ( 2003) de Ángela Pradelli, Barrefondo (2010) de Félix Bruzzone, La virgen cabeza (2009) de Gabriela Cabezón Cámara y Las viudas de los jueves (2005) de Claudia Piñeiro. El enfoque se centra en utilizar la noción de ‘crisis’ como referente y marco interpretativo para comprender la complejidad de representar literariamente la realidad argentina contemporánea y sus procesos de exclusión social. Desde la perspectiva del conurbano bonaerense, estos textos ofrecen una visión matizada de las crisis recurrentes en Argentina, explorando cómo afectan identidades y espacios. Las narrativas de estos autores no solo traducen …

Generating Assignments In Science Methods Using Research-Based Transparency: Challenging Preservice Teachers To Do Likewise, University Of Northern Iowa, Crystal Bruxvoort

University Faculty Publications and Creative Works

North Central-Association for Science Teacher Education (NC-ASTE) regional meeting

Computational Immune Synapse Analysis Reveals T-Cell Interactions In Distinct Tumor Microenvironments., Victor G Wang, Zichao Liu, Jan Martinek, Ali Foroughi Pour, Jie Zhou, Hannah Boruchov, Kelly Ray, Karolina Palucka, Jeffrey Chuang

Faculty Research 2024

The tumor microenvironment (TME) and the cellular interactions within it can be critical to tumor progression and treatment response. Although technologies to generate multiplex images of the TME are advancing, the many ways in which TME imaging data can be mined to elucidate cellular interactions are only beginning to be realized. Here, we present a novel approach for multipronged computational immune synapse analysis (CISA) that reveals T-cell synaptic interactions from multiplex images. CISA enables automated discovery and quantification of immune synapse interactions based on the localization of proteins on cell membranes. We first demonstrate the ability of CISA to detect …

Global Burden Of Bacterial Antimicrobial Resistance 1990–2021: A Systematic Analysis With Forecasts To 2050, Gbd 2021 Antimicrobial Resistance Collaborators, Geminn Louis C. Apostol

Ateneo School of Medicine and Public Health Publications

Background

Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed estimates for several WHO regions by country. To date, there have been no studies that produce comprehensive estimates of AMR burden across locations that encompass historical trends and future forecasts.

Methods

We estimated all-age and age-specific deaths and disability-adjusted life-years (DALYs) attributable to and associated with bacterial AMR for 22 pathogens, 84 pathogen–drug combinations, and 11 infectious syndromes in 204 countries and territories from …

Msgt Thomas Mack Jr

African American Funeral Programs

No abstract provided.

Trophic Niche Of A Nonnative Invader And Environmental Drivers Of Its Increasing Populations In The Coastal Everglades, Grace Kahmann, Jennifer S. Rehage, Jordan A. Massie, James A. Nelson, Rolando O. Santos, Natasha M. Viadero, W. Ryan James, Ross E. Boucek, Derek P. Crane, Ryan J. Rezek

Marine Science

The Florida Everglades is a critically important, but highly threatened ecosystem that is becoming increasingly susceptible to the invasion of non-native species. This study investigated the ecological role of the invasive peacock eel (Macrognathus siamensis) within this ecosystem using 15 years of electrofishing data and stable isotope analysis. We investigated the population trends of peacock eels at the marsh-mangrove ecotone of the Shark River Estuary, the environmental factors contributing to their abundance, and the potential interactions they may have with native fish assemblages and coastal food webs. We used stable isotope analysis to provide insights into the basal resource contribution …

Longtime Ole Miss Supporters Fund New Student, Faculty Endowments, Tina H. Hahn

University of Mississippi News

OXFORD, Miss. – Rosemary and Sandy Williams, who have been active in various community-building initiatives over the years, are giving $250,000 for University of Mississippi student scholarships and faculty support.

S6k1 Controls Dna Damage Signaling Modulated By The Mrn Complex To Induce Radioresistance In Lung Cancer, Ali Calderon-Aparicio, Jun He, Nicole L. Simone

Department of Radiation Oncology Faculty Papers

Radiation is a mainstay of lung cancer treatment; however, resistance frequently develops. Identifying novel therapeutic targets to increase radiation sensitivity is crucial. S6K1 is a serine/threonine kinase known to regulate protein translation which is associated with radioresistance, but the mechanisms involved are unknown. We proposed to determine whether S6K1 promotes radioresistance by regulating DNA repair in lung cancer. Colony formation, protein expression and proliferation were assessed. S6K1 was modulated pharmacologically by either PF-4708671 or genetically by Crispr-Cas9. Higher radioresistance levels in lung cancer cells were associated with lower phosphoactivation of MRN complex members, a key activator of radiation-induced DNA repair …

Nanopore Signal Deviations From Pseudouridine Modifications In Rna Are Sequence-Specific: Quantification Requires Dedicated Synthetic Controls, Amr Makhamreh, Sepideh Tavakoli, Ali Fallahi, Xinqi Kang, Howard Gamper, Mohammad Nabizadehmashhadtoroghi, Miten Jain, Ya-Ming Hou, Sara H Rouhanifard, Meni Wanunu

Department of Biochemistry and Molecular Biology Faculty Papers

Chemical modifications to mRNA respond dynamically to environmental cues and are important modulators of gene expression. Nanopore direct RNA sequencing has been applied for assessing the presence of pseudouridine (ψ) modifications through basecalling errors and signal analysis. These approaches strongly depend on the sequence context around the modification, and the occupancies derived from these measurements are not quantitative. In this work, we combine direct RNA sequencing of synthetic RNAs bearing site-specific modifications and supervised machine learning models (ModQuant) to achieve near-analytical, site-specific ψ quantification. Our models demonstrate that the ionic current signal features important for accurate ψ classification are sequence …

Urinary Tract Infection Caused By Gardnerella Vaginalis In A 6 Week Old Infant, Rhythm Sharma, Malika Goel, Ruba Barbar

Conference Presentation Abstracts

Introduction: Gardnerella vaginalis is a frequent cause of bacterial vaginosis (BV) in adults. However, G. vaginalis infection is infrequent in infants. Only a few cases of G. vaginalis UTI have been reported so far in infants and none in the United States.

Case Description: A 6-week-old female, ex full-term at 39 3/7 weeks via vaginal delivery with no significant postnatal medical history, presented with a 2-day history of fever, mild cough, and congestion.

In the emergency department, the patient was febrile to 38.1°C, pulse 139 beats/minute, respiratory rate 34 breaths/minute, and SpO2 98% on room air. She was active and …

A Framework For Human Evaluation Of Large Language Models In Healthcare Derived From Literature Review, Katelyn Polanska, Karleigh R Mccarthy, Hunter Osterhoudt, Xizhi Wu, Shyam Visweswaran, Sunyang Fu, Piyush Mathur, Giovanni E Cacciamani, Cong Sun, Yifan Peng, Yanshan Wang

Faculty, Staff and Student Publications

With generative artificial intelligence (GenAI), particularly large language models (LLMs), continuing to make inroads in healthcare, assessing LLMs with human evaluations is essential to assuring safety and effectiveness. This study reviews existing literature on human evaluation methodologies for LLMs in healthcare across various medical specialties and addresses factors such as evaluation dimensions, sample types and sizes, selection, and recruitment of evaluators, frameworks and metrics, evaluation process, and statistical analysis type. Our literature review of 142 studies shows gaps in reliability, generalizability, and applicability of current human evaluation practices. To overcome such significant obstacles to healthcare LLM developments and deployments, we …

In Vitro Profiling Of The Antiviral Peptide Tat-I24, Theodhora Ziu, Ezgi Sambur, Zsolt Ruzsics, Hartmut Hengel, Reingard Grabherr, Siegfried Hofinger, Hanna Harant

Michigan Tech Publications

The synthetic peptide TAT-I24 (GRKKRRQRRRPPQCLAFYACFC) exerts antiviral activity against several double-stranded (ds) DNA viruses, including herpes simplex viruses, cytomegalovirus, some adenoviruses, vaccinia virus and SV40 polyomavirus. In the present study, in vitro profiling of this peptide was performed with the aim of characterizing and improving its properties for further development. As TAT-I24 contains three free cysteine residues, a potential disadvantageous feature, peptide variants with replacements or deletions of specific residues were generated and tested in various cell systems and by biochemical analyses. Some cysteine replacements had no impact on the antiviral activity, such as the deletion of cysteine 14, which …

Electronic Communication Between Co And Ru Sites Decorated On Nitrogen-Doped Carbon Nanotubes Boost The Alkaline Hydrogen Evolution Reaction, Meng-Ting Gao, Ying Wei, Xue-Meng Hu, Wenj-Jie Zhu, Qing-Qing Liu, Jin-Yuan Qiang, Wan-Wan Liu, Ying Wang, Xu Li, Jian-Feng Huang, Yong-Qiang Feng

Journal of Electrochemistry

Designing highly efficient Pt-free electrocatalysts with low overpotential for an alkaline hydrogen evolution reaction (HER) remains a significant challenge. Here, a novel and efficient cobalt (Co), ruthenium (Ru) bimetallic electrocatalyst composed of CoRu nanoalloy decorated on the N-doped carbon nanotubes (CoRu@N-CNTs), was prepared by reacting fullerenol with melamine via hydrothermal treatment and followed by pyrolysis. Benefiting from the electronic communication between Co and Ru sites, the as-obtained CoRu@N-CNTs catalyst exhibited superior electrocatalytic HER activity. To deliver a current density of 10 mA·cm^–2, it required an overpotential of merely 19 mV along with a Tafel slope of 26.19 mV·dec …

A Case Of Acquired Cystic Kidney Disease From Chronic Renal Failure Without Dialysis, Emily Quintero, Kebir Bedran

All Publications

The kidneys play a vital role in maintaining homeostasis by filtering the blood of waste products and toxins, maintaining a delicate balance of fluids and electrolytes, and closely regulating blood pressure via the juxtaglomerular apparatus. Cystic kidney disease is a pathology of the kidneys that can be either acquired or congenital. This case report introduces a seventy-eight-year-old male with a medical history of a myocardial infarction and heart valve replacements who presented to the emergency department due to a recent fall at home unrelated to syncope. As he rose from his chair, the patient fell forward but was able to …

Zhong-Qun Tian, Academician And Honorary Member Of Electrochemistry Committee Chinese Chemical Society, Achieved "Raman Lifetime Award", Editorial Office Of J.Electrochem.

Journal of Electrochemistry

No abstract provided.

Optimization Of Channel Structure Of Alkaline Water Electrolyzer By Using An Expanded Mesh As A Bipolar Plate, Hai-Yan Xiong, Zhen-Xiao Zhu, Xin Gao, Chen-Ming Fan, Hui-Bao Luan, Bing Li

Journal of Electrochemistry

Alkaline water electrolysis (AWE) is the most mature technology for hydrogen production by water electrolysis. Alkaline water electrolyzer consists of multiple electrolysis cells, and a single cell consists of a diaphragm, electrodes, bipolar plates and end plates, etc. The existing industrial bipolar plate channel is concave-convex structure, which is manufactured by complicated and high-cost mold punching. This structure still results in uneven electrolyte flow and low current density in the electrolytic cell, further increasing in energy consumption and cost of AWE. Thereby, in this article, the electrochemical and flow model is firstly constructed, based on the existing industrial concave and …