Digital Commons Network^™

Impact Of Rural Living On Long Term Health Outcomes, Adair Tilghman, Grace Myklebust, Kristen Seeley, Michele Shaw

NURS 404/406 Research & Info Management

Research Question:

How does living in rural settings impact the health outcomes of adults?

Forecasting The Effects Of Smoking Prevalence Scenarios On Years Of Life Lost And Life Expectancy From 2022 To 2050: A Systematic Analysis For The Global Burden Of Disease Study 2021, Gbd 2021 Tobacco Forecasting Collaborators

Ateneo School of Government Publications

Background

Smoking is the leading behavioural risk factor for mortality globally, accounting for more than 175 million deaths and nearly 4·30 billion years of life lost (YLLs) from 1990 to 2021. The pace of decline in smoking prevalence has slowed in recent years for many countries, and although strategies have recently been proposed to achieve tobacco-free generations, none have been implemented to date. Assessing what could happen if current trends in smoking prevalence persist, and what could happen if additional smoking prevalence reductions occur, is important for communicating the effect of potential smoking policies.

Methods

In this analysis, we use …

Performance Of Project Delivery Methods For Us Airport Projects: A Holistic Quantitative Risk-Based Assessment Through Perceptions Of Associated Industry Experts, Ramy Khalef, Islam H. El-Adaway

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

The aviation sector received an underperforming D+ score, indicating its deteriorating qualities in comparison with the overall US infrastructure. In response, US governmental bodies issued investment bills that target the improvement of the nation's airport system. Airport projects are still being implemented through design-bid-build (DBB), which is notorious for its ineffective risk shift, low contractor input, and poor cost and schedule performance. Studies show that design-build (DB) possesses prospective cost and schedule benefits. Despite this, there is still reluctance toward DB's usage in airport projects. Moreover, current studies lack in offering frameworks that assist airport practitioners in guiding stakeholders toward …

Behavioral And Neural Evidence For Perceptual Inference Of Position, Sharif Saleki

Dartmouth College Ph.D Dissertations

Extensive neuroscientific research has advanced our knowledge of the mechanisms involved in the detection and recognition of visual stimuli. However, to guide flexible behavior in a changing world, the brain must also construct stable and coherent perceptual representations from retinal images that are often ambiguous. To resolve ambiguities and uncertainties, the visual system combines its input with other sources of information such as context and prior knowledge to infer the most likely interpretation of a scene. Thus, perception is inherently an inferential process that goes beyond simple detection or recognition of stimuli. Although inference has been studied in many areas …

Regulation Of Fibrinogen Synthesis, Marguerite Neerman-Arbez

Faculty, Staff and Student Publications

The plasma protein fibrinogen is encoded by 3 structural genes (FGA, FGB, and FGG) that are transcribed to mRNA, spliced, and translated to 3 polypeptide chains (Aα, Bβ, and γ, respectively). These chains are targeted for secretion, decorated with post-translational modifications, and assembled into a hexameric “dimer of trimers” (AαBβγ)2. Fully assembled fibrinogen is secreted into the blood as a 340 kDa glycoprotein. Fibrinogen is one of the most prevalent coagulation proteins in blood, and its expression is induced by inflammatory cytokines, wherein circulating fibrinogen levels may increase up to 3-fold during acute inflammatory events. Abnormal …

Incarcerated Person Litigation | Notes, Arthur S. Leonard

Other Publications

No abstract provided.

Criminal Litigation | Notes, Arthur S. Leonard

Other Publications

No abstract provided.

Civil Litigation | Notes, Arthur S. Leonard

Other Publications

No abstract provided.

Shared Trauma: An Evolutionary Model Concept Analysis In Light Of Covid-19, April Hutto, Phyllis Raynor Phd, Aprn, Pmhnp-Bc, Beverly Baliko Phd, Rn, Pmhnp-Bc

Publications

Shared trauma (ST) is a term historically applied to social work experiences, but other healthcare professionals (HCP) also experience ST. With the occurrence of COVID-19, ST has impacted HCP globally and has led to new discoveries and more questions regarding its scope, impact and duration. This article aims to explore the concept of ST applied to nurses in light of COVID-19 using the Rogers and Knafl Evolutionary Model for Concept Analysis. Further examination and evolution of ‘shared trauma’, particularly during COVID-19, has led to the development of an adapted model to explore the implications of ST on health-related outcomes for …

Gaze Tracking Embedded Collaborative Robots For Automated Metrology And Reverse Engineering, Sachithra H. Karunathilake, Md Shahriar Forhad, Zhaohui Geng

Manufacturing & Industrial Engineering Faculty Publications

Conventional geometric metrology, or three-dimensional (3D) scanning, and reverse engineering heavily rely on the experience of the operators. With an increasing need for automation, robot arms have been adopted for this task. However, due to the large variety of parts and designs, automated path planning could provide a scanning solution that may overlook the critical area, which could potentially deteriorate the scan results. This article explores the integration of collaborative robotics (cobots) with eye-tracking technology to improve the autonomous 3D scanning process. The primary objective of this study is to enhance the accuracy and efficiency of cobots in 3D scanning, …

Prediction Of Tool Wear And Surface Finish Using Anfis Modelling During Turning Of Carbon Fiber Reinforced Plastic (Cfrp) Composites, Anil K. Srivastava, Md. Mofakkirul Islam

Manufacturing & Industrial Engineering Faculty Publications

Carbon fiber-reinforced plastics (CFRP) are widely used in various industries due to their high strength to weight ratio, corrosion resistance, durability, and excellent thermo-mechanical properties. The machining of CFRP composites has always been a challenge for the manufacturers. In this study, CNC turning operation with coated carbide tool is used to machine a specific CFRP and the relationship between the cutting parameters (Speed, Feed, Depth of Cut) and response parameters (Vibration, Surface Finish, Cutting Force and Tool Wear) are investigated. An adaptive-network-based fuzzy inference system (ANFIS) model with two multi-input–single-output (MISO) system has been developed to predict the tool wear …

Data-Driven Roughness Estimation Of Additively Manufactured Samples Using Build Angles, Jose Galarza, Jose Barron Jr., Farid Ahmed, Jianzhi Li

Manufacturing & Industrial Engineering Faculty Publications

Achieving control of Laser Powder Bed Fusion (L-PBF) over the quality of the print is the main motivation for finding an optimum set of parameters in the process. Surface roughness is one of the characteristics of the print that impacts the performance of the desired functionality. This research focus is to relate the build angle with the surface roughness on the L-PBF printed specimens and utilize machine learning methods for roughness estimation of geometric features with varying build angles. The EOS M290 L-PBF printer was used to print Inconel-718 coupons using standard process parameters while varying build angles from 20 …

Enhancing Resilience In Complex Energy Systems Through Real-Time Anomaly Detection: A Systematic Literature Review, Ali Aghazadeh Ardebili, Oussama Hasidi, Ahmed Bendaouia, Adem Khalil, Sabri Khalil, Dalila Luceri, El Hassan Abdelwahed, Sara Qassimi, Antonio Ficarella

Manufacturing & Industrial Engineering Faculty Publications

As real-time data sources expand, the need for detecting anomalies in streaming data becomes increasingly critical for cutting edge data-driven applications. Real-time anomaly detection faces various challenges, requiring automated systems that adapt continuously to evolving data patterns due to the impracticality of human intervention. This study focuses on energy systems (ES), critical infrastructures vulnerable to disruptions from natural disasters, cyber attacks, equipment failures, or human errors, leading to power outages, financial losses, and risks to other sectors. Early anomaly detection ensures energy supply continuity, minimizing disruption impacts, an enhancing system resilience against cyber threats. A systematic literature review (SLR) is …

Equipping Future Physicians With Artificial Intelligence Competencies Through Student Associations, Spencer Hopson, Carson Mildon, Kyle Hassard, Paul Urie, Dennis Della Corte

Faculty Publications

Advances in artificial intelligence (AI) in the medical sector necessitate the development of AI literacy among future physicians. This article explores the pioneering efforts of the AI in Medicine Association (AIM) at Brigham Young University, which offers a framework for undergraduate pre-medical students to gain hands-on experience, receive principled education, explore ethical considerations, and learn appraisal of AI models. By supplementing formal, university-organized pre-medical education with a student-led, faculty-supported introduction to AI through an extracurricular academic association, AIM alleviates apprehensions regarding AI in medicine early and empowers students preparing for medical school to navigate the evolving landscape of AI in …

Acute Changes In Liver Function Tests During Initiation Of Ketogenic Diet, Maureen Handoko, James John Riviello

Faculty, Staff and Students Publications

BACKGROUND: Ketogenic diet is an effective therapy for patients with medically refractory epilepsy. It is generally well tolerated, with the most common side effects being gastrointestinal. Hepatic toxicity has been described as an uncommon side effect of ketogenic diet, usually with long-term use. However, there are limited data to implicate ketogenic diet in acute liver toxicity.

METHODS AND RESULTS: We analyzed all patients who underwent elective inpatient ketogenic diet initiation at our institution from June 2019 to June 2022. Of the 25 patients reviewed, we found 6 patients who showed acute, asymptomatic changes in liver function tests during initiation, in …

Correspondence Re Essam El-Sayed Felaya Et Al, Minsu Seo, Taeheon Lee, Yonghoon Lee, Michael Y Lee

Faculty, Staff and Students Publications

No abstract provided.

Novel Genes Of The Male Reproductive System: Potential Roles In Male Reproduction And As Non-Hormonal Male Contraceptive Targets

Faculty, Staff and Students Publications

The development of novel non-hormonal male contraceptives represents a pivotal frontier in reproductive health, driven by the need for safe, effective, and reversible contraceptive methods. This comprehensive review explores the genetic underpinnings of male fertility, emphasizing the crucial roles of specific genes and structural variants (SVs) identified through advanced sequencing technologies such as long-read sequencing (LRS). LRS has revolutionized the detection of structural variants and complex genomic regions, offering unprecedented precision and resolution over traditional next-generation sequencing (NGS). Key genetic targets, including those implicated in spermatogenesis and sperm motility, are highlighted, showcasing their potential as non-hormonal contraceptive targets. The review …

Long Covid Among Undocumented Latino Immigrant Populations In The Emergency Department, Vijaya Arun Kumar, Michael Gottlieb, Kristin L Rising, Robert M Rodriguez

Faculty, Staff and Students Publications

This cross-sectional study assesses the understanding of and access to care for long COVID symptoms among undocumented Latino immigrants in US emergency departments (EDs).

Evaluating Progress And Accountability For Achieving Cop26 Health Programme International Ambitions For Sustainable, Low-Carbon, Resilient Health-Care Systems, Matthew J Eckelman, Meghnath Dhimal, Martin Hensher, Renzo R Guinto, Alice Mcgushin, Xuejuan Ning, Poornima Prabhakaran, Marina Romanello, Dana Van Alphen, Nick Watts, Jessica C Yu, Carol Zavaleta-Cortijo, Andrea J Macneill, Jodi D Sherman

Faculty, Staff and Students Publications

A global initiative to develop low-carbon, resilient health systems-the COP26 Health Programme-launched at the UN Framework Convention on Climate Change 26th Conference of the Parties (COP26) in 2021. As of May, 2024, 83 nations have committed to participate in this initiative. This analysis evaluates the effectiveness of existing and proposed indicators towards public monitoring and accountability to these commitments. Our findings reveal substantial gaps in data availability and indicator relevance, with many countries reporting process indicators that do not reflect actual progress towards achieving sustainable health-care systems. We found a dearth of suitable indicators and an urgent need to develop …

A Genome-Wide Association Study Of The Count Of Codeine Prescriptions, Aurélien Simona, Scott G Weiner, Richard D Urman, Kenneth J Mukamal, Adam Wright, David W Bates

Faculty, Staff and Students Publications

Opioid prescription records in existing electronic health record (EHR) databases are a potentially useful, high-fidelity data source for opioid use-related risk phenotyping in genetic analyses. Prescriptions for codeine derived from EHR records were used as targeting traits by screening 16 million patient-level medication records. Genome-wide association analyses were then conducted to identify genomic loci and candidate genes associated with different count patterns of codeine prescriptions. Both low- and high-prescription counts were captured by developing 8 types of phenotypes with selected ranges of prescription numbers to reflect potentially different levels of opioid risk severity. We identified one significant locus associated with …

Ficture: Scalable Segmentation-Free Analysis Of Submicron-Resolution Spatial Transcriptomics, Weiqiu Cheng, Asma Nusrat, Weizhou Zhang, Goo Jun, Sebastian Zöllner, Jun Hee Lee, Hyun Min Kang

Faculty, Staff and Student Publications

Spatial transcriptomics (ST) technologies have advanced to enable transcriptome-wide gene expression analysis at submicron resolution over large areas. However, analysis of high-resolution ST is often challenged by complex tissue structure, where existing cell segmentation methods struggle due to the irregular cell sizes and shapes, and by the absence of segmentation-free methods scalable to whole-transcriptome analysis. Here we present FICTURE (Factor Inference of Cartographic Transcriptome at Ultra-high REsolution), a segmentation-free spatial factorization method that can handle transcriptome-wide data labeled with billions of submicron-resolution spatial coordinates and is compatible with both sequencing-based and imaging-based ST data. FICTURE uses the multilayered Dirichlet model …

Integrated Safety And Efficacy Analyses Of Phase 3 Trials Of A Microbiome Therapeutic For Recurrent Cdi, Thomas J Louie, Paul Feuerstadt, Edward S Huang, Sahil Khanna, Charles S Berenson, Elaine E L Wang, Stuart H Cohen, Louis Korman, Christine Lee, Colleen R Kelly, Alberto Odio, Paul P Cook, Bret Lashner, Mayur Ramesh, Princy Kumar, Ananya De, Asli Memisoglu, David A Lombardi, Brooke R Hasson, Barbara H Mcgovern, Lisa Von Moltke, Darrell S Pardi, Ecospor Iii And Ecospor Iv Investigators

Faculty, Staff and Students Publications

INTRODUCTION: Recurrent Clostridioides difficile infection (rCDI) often occurs after standard-of-care antibiotics. VOWST oral spores (VOS, previously SER-109), an FDA-approved orally administered microbiome therapeutic, is indicated to prevent rCDI following antibiotics for rCDI.

OBJECTIVE, DESIGN, AND PATIENTS: To evaluate safety and efficacy of VOS from two phase 3 trials, (randomized, placebo-controlled [ECOSPOR III: NCT03183128] and open-label, single arm [ECOSPOR IV: NCT03183141]) of 349 adults with rCDI and prevalent comorbidities.

METHODS: VOS or placebo [ECOSPOR III only] (4 capsules once daily for 3 days). Integrated analysis of treatment-emergent adverse events (TEAEs) collected through week 8; serious TEAEs and TEAEs of special interest …

Galectin 3-Binding Protein (Lgals3bp) Depletion Attenuates Hepatic Fibrosis By Reducing Transforming Growth Factor-Β1 (Tgf-Β1) Availability And Inhibits Hepatocarcinogenesis, Eun-Gene Sun, Sumin Yoon, Kyung Hyun Yoo, Kamalakannan Radhakrishnan, Sung Yun Jung, Woo-Kyun Bae, Sang-Hee Cho, Ik-Joo Chung

Faculty, Staff and Students Publications

Background: Increased Galectin 3-binding protein (LGALS3BP) serum levels have been used to assess hepatic fibrosis stages and the severity of hepatocellular carcinoma (HCC). Considering the crucial role of transforming growth factor-β1 (TGF-β1) in the emergence of these diseases, the present study tested the hypothesis that LGALS3BP regulates the TGF-β1 signaling pathway.

Methods: The expression levels of LGALS3BP and TGFB1 were analyzed in patients with metabolic dysfunction-associated steatohepatitis (MASH) and HCC. Multiple omics techniques, such as RNA-sequencing, transposase-accessible chromatin-sequencing assay, and liquid chromatography-tandem mass spectrometry proteomics, were used to identify the regulatory mechanisms for the LGALS3BP-TGF-β1 axis. The effects of altered …

Stareg: Statistical Replicability Analysis Of High Throughput Experiments With Applications To Spatial Transcriptomic Studies, Xianyang Zhang, Hongyuan Cao

Faculty, Staff and Students Publications

Replicable signals from different yet conceptually related studies provide stronger scientific evidence and more powerful inference. We introduce STAREG, a statistical method for replicability analysis of high throughput experiments, and apply it to analyze spatial transcriptomic studies. STAREG uses summary statistics from multiple studies of high throughput experiments and models the the joint distribution of p-values accounting for the heterogeneity of different studies. It effectively controls the false discovery rate (FDR) and has higher power by information borrowing. Moreover, it provides different rankings of important genes. With the EM algorithm in combination with pool-adjacent-violator-algorithm (PAVA), STAREG is scalable to datasets …

The Association Between Vaso/Pressin And Adverse Kidney Outcomes In Children And Young Adults Requiring Vasopressors On Continuous Renal Replacement Therapy, Erin K Stenson, Aaron Kessel, Taiki Haga, Sara Lafever, Maria Jose Santiago, Matthew Barhight, David Selewski, Zaccaria Ricci, Nicholas J Ollberding, Natalja L Stanski, The Worldwide Exploration Of Renal Replacement Outcomes Collaborative In Kidney Disease (We-Rock) Collaborative

Faculty, Staff and Students Publications

OBJECTIVES: Continuous renal replacement therapy (CRRT) and shock are both associated with high morbidity and mortality in the ICU. Adult data suggest renoprotective effects of vasopressin vs. catecholamines (norepinephrine and epinephrine). We aimed to determine whether vasopressin use during CRRT was associated with improved kidney outcomes in children and young adults.

DESIGN: Secondary analysis of Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK), a multicenter, retrospective cohort study.

SETTING: Neonatal, cardiac, PICUs at 34 centers internationally from January 1, 2015, to December 31, 2021.

PATIENTS/SUBJECTS: Patients younger than 25 years receiving CRRT for acute kidney injury and/or …

Design And Cohort Characteristics Of Track, A Prospective Study Of Hyperkalaemia Management Decision-Making, Jordi Bover, Javed Butler, Pietro Manuel Ferraro, Linda Fried, Markus P Schneider, Navdeep Tangri, Wolfgang C Winkelmayer, Meredith Bishop, Hungta Chen, Anna-Karin Sundin, Marc P Bonaca

Faculty, Staff and Students Publications

BACKGROUND: Guideline-recommended hyperkalaemia management includes dietary potassium (K

METHODS: This study enrolled participants within 21 days of an episode of hyperkalaemia in four European countries (UK, Spain, Germany, Italy) and the USA. During the 12-month follow up, data collected will include participant and healthcare provider characteristics (specialty and practice setting), hyperkalaemia treatment objectives and strategies, rationale for management decisions and indicators of response and patient-reported perceptions of their hyperkalaemia treatment.

RESULTS: The enrolled cohort includes 1330 participants, mean age 68 years, of whom 31% were women. At baseline, 6% reported heart failure, 55% chronic kidney disease, 29% both and 9% …

The Nature Of Adverse Events In Dentistry, Bunmi Tokede, Alfa Yansane, Muhammad F. Walji, D. B. Rindal, Don Worley, Joel White, Elsbeth Kalenderian

School of Dentistry Faculty Research and Publications

Objectives

Learning from clinical data on the subject of safety with regards to patient care in dentistry is still largely in its infancy. Current evidence does not provide epidemiological estimates on adverse events (AEs) associated with dental care. The goal of the dental practice study was to quantify and describe the nature and severity of harm experienced in association with dental care, and to assess for disparities in the prevalence of AEs.

Methods

Through a multistaged sampling procedure, we conducted in-depth retrospective review of patients’ dental and medical records.

Results

We discovered an AE proportion of 1.4% (95% CI, 1.1% …

Leveraging The Federal Depository Library (Fdl) Conference To Provide Pathways For Exploring Government Resources And Expanding Professional Presentation Skills, Raquel Estrada, Shannon Pensa

University Library Publications and Presentations

When is a conference more than just a conference? Can the FDL Conference be a platform for more than connecting with colleagues and researching government documents? Librarians from The University of Texas Rio Grande Valley Acquisitions and Collection Development and Special Collections and Archives explore how the FDL conference might serve as a gateway to promoting government resources and building communication and presentation skills. Our goal is to think beyond the traditional approaches to conference participation as a space to connect, and showcase knowledge, and to consider how the conference might serve as a unique platform for library paraprofessional staff …

Valentine’S Day @ The Library, Raquel Estrada

University Library Publications and Presentations

The University Library celebrated its first Valentine’s Day @ the Library event in 2024 with the aim of promoting government resources. To capture patron attention this event highlighted free printable Valentine cards available from various government websites. To support this activity, digital posters were created promoting government resources, and an information table was set up featuring some of the printable Valentine cards and promotional material from the Federal Depository Library Program (FDLP). With positive response towards programming, we are expecting to continue this event in the future.

Evaluating The Efficacy Of And Preference For Interactive Computer Training With Student-Generated Examples, Sylvia C. Aquino, Stephanie Hood, Tara A. Fahmie, Richard Tanis

Psychology Faculty Research and Publications

Designing effective and preferred teaching practices for undergraduate students are common goals in behavior analytic training programs. A preliminary study by Nava et al. (2019) showed that undergraduate students generally rated peer-generated examples of the principles of behavior analysis as more preferred, relatable, and culturally responsive than traditional textbook examples. However, peer-generated examples did not result in any improvement in performance on concept knowledge assessments. The current study extended the study by Nava et al. by embedding peer-generated examples within interactive computer training (ICT) to provide opportunities for active responding, prompt fading, automated feedback, and practice with examples and nonexamples. …