Digital Commons Network^™

Diverse Disconnectedness: Homophily, Social Capital Inequality, And Student Experiences In Law School, Anthony Paik, Swethaa Ballakrishnen, Carole Silver, Steven Boutcher, Tanya Rouleau Whitworth

Faculty Publications

Law school students are encouraged frequently to “network.” However, depending on demographic categories, they may have access to differently resourced social networks in law school. In this article, we draw from our mixed-methods research to explore this diversity of experience, its limitations of access, and the possible network inequalities that may limit the value of legal education to diverse students across different institutional contexts. Using survey and network data (N = 744), collected during the fall of 2019 from three law schools, as well as supplementary interview data (N = 55), we examined students’ social networks, the structures of these …

Impact Of Age On Pharmacogenomics And Treatment Outcomes Of B-Cell Acute Lymphoblastic Leukemia, Satoshi Yoshimura, Zhenhua Li, Yoshihiro Gocho, Wenjian Yang, Kristine R Crews, Kathryn G Roberts, Mary V Relling, Jiyang Yu, Allen E J Yeoh, Mignon L Loh, Caner Saygin, Mark R Litzow, Sima Jeha, Seth E Karol, Hiroto Inaba, Ching-Hon Pui, Marina Konopleva, Nitin Jain, Wendy Stock, Elisabeth Paietta, Elias Jabbour, Steven M Kornblau, William E Evans, Jun J Yang

Faculty, Staff and Student Publications

Purpose: Acute lymphoblastic leukemia (ALL) can occur across all age groups, with a strikingly higher cure rate in children compared with adults. However, the pharmacological basis of age-related differences in ALL treatment response remains unclear.

Methods: Studying 767 children and 309 adults with newly diagnosed B-cell ALL enrolled on frontline trials at St Jude Children's Research Hospital, MD Anderson Cancer Center, the Alliance for Clinical Trials in Oncology, and the ECOG-ACRIN Cancer Research Group, we determined the ex vivo sensitivity of leukemia cells to 21 drugs. Twenty-three ALL molecular subtypes were identified using RNA sequencing. We systematically characterized the associations …

Assessing Water Clarity Status And Long-Term Trends In North America's Largest Lakes Using Esa's Ocean Colour Climate Change Initiative (Oc-Cci) Products, Caren Binding, Matt Morison, Michael Sayers, Karl Bosse, Xinhua Zhu, Chuiqing Zeng, Varunan Theenathayalan

Michigan Tech Publications

Water clarity, as measured by Secchi disk depth (ZSD) or diffuse attenuation (Kd), is an important indicator of a lake's ecosystem state and can be reliably retrieved using satellite remote sensing. By combining data from multiple satellite missions, the European Space Agency's Ocean Colour Climate Change Initiative (OC-CCI) aims to deliver stable, long-term, satellite data products suitable for trend assessments. Here we demonstrate the value of OC-CCI products for reporting on water clarity status and long-term trends in North America's largest lakes. Extensive matchups between the OC-CCI Kd at 490 nm (Kd490) and in situ ZSD observations spanning 25 years …

Aligning The World Health Organization's (Who) Package Of Interventions For Rehabilitation For Cancer With The Mission Of The International Psycho-Oncology Society's: Promoting Psychosocial Care For All People Affected By Cancer, Christina Signorelli, Nicolas H. Hart, Louise Mullen, Larissa Nekhlyudov, Luzia Travado, Wendy W.T. Lam, Melissa Henry, Csaba László Dégi, Darren Haywood, Michael Jefford

Research outputs 2022 to 2026

The number of people living with and beyond cancer continues to increase worldwide, bringing significant attention to their rehabilitation needs. Globally, psychosocial services are largely inadequate, with many cancer survivors experiencing unmet psychosocial needs. The World Health Organization (WHO) recognizes rehabilitation as an essential component of universal health coverage to prevent disease-related conditions, while also improving physical and mental functioning and overall well-being. The Package of Interventions for Rehabilitation (PIR) was developed by the WHO to address the global need for rehabilitation across 20 conditions with high prevalence and high levels of associated disability, including cancer. Many aspects of the …

Larp1 Haploinsufficiency Is Associated With An Autosomal Dominant Neurodevelopmental Disorder, Robert Best, Kevin Chen, Josephine Morris, Zinaida Dedeic, Anna Childers, R Curtis Rogers, Barbara R Dupont, Cindy Skinner, Sébastien Küry, Kevin Uguen, Marc Planes, Danielle Monteil, Megan Li, Aviva Eliyahu, Lior Greenbaum, Nofar Mor, Thomas Besnard, Bertrand Isidor, Benjamin Cogné, Alyssa Blesson, Anne Comi, Ingrid M Wentzensen, Blake Vuocolo, Seema R Lalani, Roberta Sierra, Lori Berry, Kent Carter, Stephan J Sanders, Sarah P Blagden

Faculty, Staff and Students Publications

Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects approximately 4% of males and 1% of females in the United States. While causes of ASD are multi-factorial, single rare genetic variants contribute to around 20% of cases. Here, we report a case series of seven unrelated probands (6 males, 1 female) with ASD or another variable NDD phenotype attributed to de novo heterozygous loss of function or missense variants in the gene LARP1 (La ribonucleoprotein 1). LARP1 encodes an RNA-binding protein that post-transcriptionally regulates the stability and translation of thousands of mRNAs, including those regulating cellular metabolism and …

Rapid Evolution Of Mitochondrion-Related Genes In Haplodiploid Arthropods, Robert M Waterhouse, Xin Zhou, Michael E Pfrender

Faculty, Staff and Students Publications

Background: Mitochondrial genes and nuclear genes cooperate closely to maintain the functions of mitochondria, especially in the oxidative phosphorylation (OXPHOS) pathway. However, mitochondrial genes among arthropod lineages have dramatic evolutionary rate differences. Haplodiploid arthropods often show fast-evolving mitochondrial genes. One hypothesis predicts that the small effective population size of haplodiploid species could enhance the effect of genetic drift leading to higher substitution rates in mitochondrial and nuclear genes. Alternatively, positive selection or compensatory changes in nuclear OXPHOS genes could lead to the fast-evolving mitochondrial genes. However, due to the limited number of arthropod genomes, the rates of evolution for nuclear …

Clinical And Functional Studies Of Mtor Variants In Smith-Kingsmore Syndrome Reveal Deficits Of Circadian Rhythm And Sleep-Wake Behavior, Andrew C Liu, Yang Shen, Carolyn R Serbinski, Hongzhi He, Destino Roman, Mehari Endale, Lindsey Aschbacher-Smith, Katherine A King, Jorge L Granadillo, Isabel López, Darcy A Krueger, Thomas J Dye, David F Smith, John B Hogenesch, Carlos E Prada

2020-Current year OA Pubs

Heterozygous de novo or inherited gain-of-function mutations in the MTOR gene cause Smith-Kingsmore syndrome (SKS). SKS is a rare autosomal dominant condition, and individuals with SKS display macrocephaly/megalencephaly, developmental delay, intellectual disability, and seizures. A few dozen individuals are reported in the literature. Here, we report a cohort of 28 individuals with SKS that represent nine MTOR pathogenic variants. We conducted a detailed natural history study and found pathophysiological deficits among individuals with SKS in addition to the common neurodevelopmental symptoms. These symptoms include sleep-wake disturbance, hyperphagia, and hyperactivity, indicative of homeostatic imbalance. To characterize these variants, we developed cell …

Recent Progress In Modeling And Treating Diabetes Using Stem Cell-Derived Islets, Marlie M Maestas, Maggie H Bui, Jeffrey R Millman

2020-Current year OA Pubs

Stem cell-derived islets (SC-islets) offer the potential to be an unlimited source of cells for disease modeling and the treatment of diabetes. SC-islets can be genetically modified, treated with chemical compounds, or differentiated from patient derived stem cells to model diabetes. These models provide insights into disease pathogenesis and vulnerabilities that may be targeted to provide treatment. SC-islets themselves are also being investigated as a cell therapy for diabetes. However, the transplantation process is imperfect; side effects from immunosuppressant use have reduced SC-islet therapeutic potential. Alternative methods to this include encapsulation, use of immunomodulating molecules, and genetic modification of SC-islets. …

Rethinking Our Future: Describing And Enhancing The Impacts Of Dissemination And Implementation Science For Cancer Prevention And Control, Vianca C. Soulette, Karen M. Emmons, Douglas A. Luke, Peg Allen, Bobbi J. Carothers, Ross C. Brownson

2020-Current year OA Pubs

No abstract provided.

Dubai Urban Planning 2040: Resource Requirements In The Urban District 5, Bakhit Alfalasi

Theses

The availability of water, food, energy and air quality resources is compromised by prevailing global issues like environmental stress, climate change, and population growth. This research study details the different requirements for Dubai urban District 5 based on the tenets laid out in the Urban Planning 2040 initiative. The literature review section looks into existing literature on the present state of affairs in the UAE as regards availability of water, food, and energy resources in the country and implications of their production processes on air quality. The Study will employ an exploratory research design, where a systematic review of literature …

Churning The Tides Of Care: When Nurse Turnover Makes Waves In Patient Access To Primary Care, Trang N D Pham, Laura A Petersen, Lechauncy Woodard, Richard Sorelle, Cheng Rebecca Jiang, Frederick L Oswald, Daniel R Murphy, Hilary N Touchett, Joshua Hamer, Sylvia J Hysong

Faculty, Staff and Students Publications

BACKGROUND: Team-based primary care (PC) enhances the quality of and access to health care. The Veterans Health Administration (VHA) implements team-based care through Patient Aligned Care Teams (PACTs), consisting of four core members: a primary care provider, registered nurse (RN) care manager, licensed vocational nurse, and scheduling clerk. RNs play a central role: they coordinate patient care, manage operational needs, and serve as a patient point of contact. Currently, it is not known how varying levels of RN staffing on primary care teams impact patient outcomes.

OBJECTIVE: This study aims to empirically assess how the stability of RN staffing within …

Long Term Impact Of Covid 19 On Psychiatric Health And Quality Of Life In Recovered Patients, Preetika Baghel, Pradeep Kumar P C, Kishor M

International Journal of Health and Allied Sciences

Background: Covid-19 has a devastating impact on different dimensions of life, including health. Recent studies have highlighted the effects of prolonged Covid-19 symptoms on mental health.

Aim: This study aims to 1) assess psychiatric illness among individuals previously diagnosed with COVID-19 infection and treated on an inpatient basis, and 2) evaluate the quality of life of individuals with and without psychiatric illness.

Method: This hospital-based cross-sectional study was conducted at a tertiary care general hospital in South India and involved 200 patients with COVID-19 infection who received treatment through an inpatient facility. The study utilized a sociodemographic …

Exploring High-Penetrance Genes In Breast Cancer Associated Genetic Syndromes: Insights Into Genetic Predisposition And Clinical Implications, Nadha Abdul Razack, Samudyata C. Prabhuswamimath

International Journal of Health and Allied Sciences

Breast cancer, the most common cancer in women globally, has a genetic predisposition in 5-10% of cases. This paper examines high-penetrant genes TP53, PTEN, CDH1, and STK11, which are associated with hereditary syndromes such as Peutz-Jeghers, Hereditary Diffuse Gastric Cancer, Cowden, and Li-Fraumeni. Mutations in these high penetrant genes significantly increases breast cancer risk, resulting in subtypes characterized by higher nuclear grading, increased invasiveness, and greater metastasis potential. Understanding the molecular mechanisms and interactions of these genes with various breast cancer subtypes is essential for improving risk assessment, early detection, and the development of personalized treatment strategies.

Sestrin 2 As A New Biomarker In Obesity And Diabetes Mellitus: A New Key Player In The Metabolic Regulation, Shashank M Patil, Jayanthi M K, Ramith Ramu

International Journal of Health and Allied Sciences

The global health crisis of diabetes linked to obesity necessitates innovative biomarkers for early diagnosis and targeted treatment. This study explores the pivotal role of sestrins, evolutionarily conserved proteins, in the intricate interplay between obesity and diabetes. Highlighting their significance as regulators of metabolic balance, stress response, and cellular homeostasis, particularly sestrin 2 (SESN2), the study delves into their impact on oxidative stress, insulin sensitivity, and inflammatory responses. Recent studies have highlighted the dysregulation of sestrins in obesity and diabetes mellitus, suggesting their potential as diagnostic markers and therapeutic targets. Examining the molecular processes involving AMP-activated protein kinase (AMPK) and …

Curating And Validating Universally Applicable Primers For Efficient Its2-Based Dna Barcoding Across Plant Taxa, Ajay R Bhat, Subrahmanya Hegde, Supriya S Kammar, Mb Muthamma, Gaurav Mudgal, Prashanth Babu H, Rajulu Charukesi, Thotegowdanapalya C Mohan

International Journal of Health and Allied Sciences

Abstract: Rapid and accurate identification of plant species increasingly seeks to employ molecular techniques. The ITS2 region is highly regarded in DNA barcoding due to its short length and ease of sequencing, making it an ideal candidate for species identification

Epitope Identification Of Rabies Virus Nucleoprotein Using Immunoinformatics Approach, Kavitha G. Manjunatha, Chandrahasa Chethana, Akhila D. Sannejal, Mohammad Shueb, Devananda Devegowda, Shashanka K. Prasad, Deepak S. Pinto, Shrikrishna Isloor

International Journal of Health and Allied Sciences

Abstract

Background

Rabies is a deadly and preventable disease. The nucleoprotein of rabies virus has been found to have group-specific antigenic determinants. The rabies virus nucleoprotein can shield dogs and mice from the lethal infection. Early diagnosis of rabies is crucial for the prevention of rabies.

Methods

In this study, B-cell epitopes of the nucleoprotein gene of the rabies virus were identified, and the characteristics of the epitopes were analyzed using various bioinformatics tools, such as the immune epitope database's Bepipred Major Histocompatibility Complex II (IEDB MHC II) prediction tool, NetCTL 1.2, Vaxijen v20, AllerTOP v2.0 server.

Results

Fourteen epitopes …

Harnessing Nature's Power Of Azolla Pinnata Superfood With Biofertilizers For A Sustainable Future, Khalander Bibi, Sushma Shree Krishnappa, Charan Kumar Kachintaya, Shankramma Kalikeri, Lingaraju Honnuru Gurusiddappa

International Journal of Health and Allied Sciences

Azolla pinnata, a rapidly growing floating aquatic fern, flourishes in freshwater bodies throughout India. It forms clusters in marshes, drains, and rice fields, doubling its biomass every 1.9 days. Azolla, known for its versatility, is used in food, medicinal, water purification, biofertilizers, and livestock feed. Its use in animal diets improves live weight, protein efficiency, and feed conversion rates. Azolla has pharmaceutical benefits in addition to agricultural, including antioxidant and immunological stimulation, as well as hepatoprotective properties. It also plays an important part in phytoremediation and bioremediation. Azolla's potential extends to biofuel production, making it a promising feedstock for sustainable …

Fabrication Of Implant Supported Hybrid Denture Using Multi-Unit Abutments In A Patient With Generalised Aggressive Periodontitis, Anupama Aradya, Raghavendra Swamy K N, Chandan S N, Prashanth M B

International Journal of Health and Allied Sciences

This case report describes the prosthodontic rehabilitation of a geriatric patient with generalized aggressive periodontitis. The patient was advised to for full extraction. An implant supported hybrid prosthesis with multi-unit abutments was fabricated for the patient who chose a fixed kind of prosthesis. Implants were placed in the maxillary & mandibular arch. Frameworks were waxed, plastic castable abutments were used for casting, denture teeth were waxed to the hybrid framework and a final wax try-in to check and adjust the maxilla-mandibular relationships before processing, the prosthesis was placed. The clinical and radiologic results met expectations.

Volume 50-2 Complete Issue, Steven M. Schnell

The Geographical Bulletin

Volume 50-2 Complete Issue

Cover And Forewords, Steven M. Schnell

The Geographical Bulletin

Cover and Forewords

Scales Of Whiteness And Racial Mixing: Challenging And Confirming Racial Categories, Serin D. Houston

The Geographical Bulletin

This paper examines personal and public portrayals of the self and family articulated by heterosexual mixed-race households living in the Pacific Northwest of the United States. It argues that an attention to scale sheds light on how mixed-race partnerships and households both reproduce a racial hierarchy and express shifting racial identities. A focus on the work of whiteness – defined here as an evaluative set of practices and processes that implicitly or explicitly legitimate a static racial hierarchy – in the confirmation of and challenges to racial categories further specifies my claims. I explore seemingly contradictory expressions of race in …

Comparison Of Recycling Rates Of Three Adjacent Communities In St. Clair County, Illinois, Pamela Lauf

The Geographical Bulletin

This research project consists of two types of surveys to assess recycling in the city limits of Belleville, Swansea, and O’Fallon, Illinois, each of which uses a different type of recycling program. One method of data collection consisted of conducting visual surveys to observe participation rates. The second was a questionnaire mailed to homes in these communities requesting information on the household’s recycling habits, attitudes toward curbside recycling, income, and highest education level achieved by head of household. This project determined that the most influential factor in determining whether people take part in a curbside recycling program is cost.

Street Trees And Urban Renewal: A Baltimore Case Study, Cynthia L. Merse, Geoffrey L. Buckley, Christopher G. Boone

The Geographical Bulletin

For centuries, street trees have persisted as enduring features of the urban landscape. Evidence shows that investing in “green infrastructure” not only contributes to a healthy ecosystem but offers economic and social benefits as well. Despite these advantages, the popularity of street trees has waxed and waned over the years in cities across the United States. The urban forest in Baltimore, Maryland has not been immune to these fluctuations, despite the city’s reputation for innovative tree care and the emphasis city officials placed on street tree planting as part of the urban renewal programs of the 1950s and 1960s. One …

A Revised Climatically Optimal Major League Baseball Season In North America, Brent R. Skeeter

The Geographical Bulletin

A study conducted in the late 1980s determined the climatically optimal placement of the Major League Baseball season based on temperature and several other climatic variables. Numerous changes have taken place in Major League Baseball since the late 1980s which could have potentially altered the placement of the climatically optimal season. This paper updates the previous work in order to determine the current climatically optimal season. The results indicate that the climatically optimal season has only changed slightly since the time of the previous study. As found in the previous study, based on climate alone, the season should begin and …

Vol. 32, No. 4-8 - Whole No. 173, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 32, No. 2/3 - Whole No. 172, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 32, No. 1 - Whole No. 171, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 31, No. 11/12 - Whole No. 170, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 31, No. 10 - Whole No. 169, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 31, No. 9 - Whole No. 168, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.