Digital Commons Network^™

Combinatorial Anti-Cancer Effect Of Polypurine Reverse Hoogsteen Hairpins Against Kras And Myc Targeting In Prostate And Pancreatic Cancer Cell Lines, Simonas Valiuska, Kayla K. Elder, Steven J. Mckay, Carlos J. Ciudad, Véronique Noé, Tracy A. Brooks

Pharmacy Faculty Scholarship

Introduction: KRAS and MYC are proto-oncogenes that are strictly regulated in healthy cells that have key roles in several processes such as cell growth, proliferation, differentiation, or apoptosis. These genes are tightly interconnected, and their dysregulation can lead to cancer progression. We previously individually targeted these oncogenes using Polypurine Reverse Hoogsteen (PPRH) hairpins, mostly targeting the complementary strand of G-quadruplex-forming sequences. We validated them in vitro in different cancer cell lines with deregulated KRAS and/or MYC. In this work we focused on our understanding of the cooperative dynamics between these oncogenes, by investigating the combined impact of PPRHs targeting KRAS …

Fs Social Justice Committee Agenda 2024-10-16, Northern Illinois University

Faculty Senate Archives

No abstract provided.

Genai Tools For Legal Research, Law Library Reference Team

Librarian Publications & Presentations

There are AI Research discovery tools that have a range of features support literature mapping, systematic literature reviews, or analyzing scholarly documents in detailed ways. Typically these research tools with search and retrieval features are connecting to academic databases, and depending on the tool, can extract key information, generate literature reviews, maps and summaries, or provide features common with citation tools.

October 16, 2024 Minutes, A-State Staff Senate

Staff Senate Minutes

No abstract provided.

Gardner-Webb, Ruby C. Hunt Ymca And Town Of Boiling Springs Host Octoberfest, Office Of University Communications

Gardner-Webb NewsCenter Archive

An annual fall tradition returns to the Gardner-Webb campus on Thursday, Oct. 24, from 6 to 8 p.m. Since 2005, Octoberfest has welcomed families, providing candy, games and fun for children. This year, the event will be held inside the Paul Porter Arena and outside, around the perimeter of Lutz-Yelton Convocation Center (LYCC).

The Moderate Use Of Wine And Alcohol Among Church Elders: An Analysis Of Νηφάλιον And Πάροινον In 1 Timothy 3:1-7 And Titus 1:5-9, Charles Douglas Tarver Miller

Doctoral Dissertations and Projects

The use of alcohol in the Bible is well established. The ancients were known to consume alcohol and fully understood the pain and pleasure associated with it. So, two things are true: the use of wine is permitted in the Scriptures, but only in moderation. Historically, the conversation about the use of wine has focused on answering the question, “Was the wine used by believers in the Scriptures alcoholic or non-alcoholic?” That debate has largely been settled and will not be the subject of this dissertation. What has not been addressed nearly as often is the question, “How was wine …

Comparison Of Redevelopment Policies, Gentrification, And Disparate Impact In Tallahassee, Dallas, And San Diego, William Dorsey

Doctoral Dissertations and Projects

Previous studies found that the economics of poverty are closely tied to property values, education, and employment. Racial disparity in income also exists today. Part of this is attributed to mass gentrification through Urban Renewal Administration programs that legally displaced entire Black neighborhoods under the purview of the Housing Act of 1954 prior to the Fair Housing Act of 1968. For example, Harlem Park was vacated and redeveloped using eminent domain. Critical Race theorists claim that these programs continue today using colorblind policies and secondary discrimination. This dissertation sought to develop a theoretical understanding of the impact ideology has on …

Educating Providers On The Utility Of Pharmacogenomic Testing, Angela L. Holloman

Doctoral Dissertations and Projects

Pharmacogenomic testing is the use of an individual’s genotype to help determine their response to certain medications metabolized by the cytochrome P450 enzyme family. This information can help to prevent adverse drug effects and guide medication selection and dosing. This testing is becoming more widely utilized and more commonly available. It is now available as a direct-to-consumer test. Many providers lack the necessary education in pharmacogenomics to utilize this technology or discuss it with their patients. Educational interventions for providers are effective at improving provider knowledge and confidence regarding pharmacogenomic testing. This practice project sought to educate providers at a …

Leadership Diversity In The Technology Industry, Renee' Y. L. Smith

Doctoral Dissertations and Projects

Diversity is a relevant topic in the modern workplace. This research is an exploration of diversity in the workplace from a leadership perspective. Specifically, this research includes the lack of leadership diversity in the technology industry and its impact on employee turnover and operational costs. The purpose of this research was to contribute to the extant body of knowledge by understanding the issue and determining factors to mitigate the issue. This study utilized a flexible design and qualitative research methodology, specifically a case study. A constructivist paradigm aligned with my Christian worldview. The study included interviews, surveys, and documents as …

The Shared Experiences Of The Effectiveness Of Christian Mindfulness Meditation For Adult Evangelical Christians In Florida Experiencing Ptsd Symptomatology, Loraine Yvonne Pennant

Doctoral Dissertations and Projects

Mindfulness meditation, though secular in origin, is a distinct Christian principle found in the Bible and are practices that Christians in general subconsciously subscribe to especially in times of traumatic stress. When adapted to reflect Christian principles, this practice should retain the basic concepts of mindfulness meditation while safeguarding the integrity of the biblical tenet. The purpose of this phenomenological study was to understand and describe the shared experiences of the effectiveness of Christian mindfulness meditation of adult evangelical Christians in Florida suffering from post-traumatic stress disorder symptomology. A gap in literature exploring the topics of Christian rumination (meditation) and …

Teachers’ Perceptions Of Preparedness For Instruction During And After Collaborative Planning, Alicia Daniels

Student Theses and Dissertations

Providing differentiated learning experiences for every student is one of the goals behind teacher collaboration (Reeves, 2003, Byrd, 2020). The problem examined in this study was that collaborative planning has been used as a solution to improve instructional quality in low-resourced schools, without assessing the effectiveness of that solution through the eyes of classroom teachers who taught solo. This problem affects teachers who must meet students’ needs during instruction and students who need access to quality instruction to experience success academically. The purpose of this study was to collect the perspectives of teachers who were currently teaching in an urban …

Poetry For The Lord Instead Of The World: A Study Of The Romantic Poets, The Imposters, And Our Response As Christians, Annabelle Camoirano

Masters Theses

When I was a little girl, I watched my grandfather read all the time. He had shelves full of books stacked on more books. My grandparents had an entire room dedicated to holding the books he’d read over the years. Almost 5 years ago now, we had to move my grandparents out of the home that they had lived in for over 40 years. Going through all those books, my dad found one he knew I had to have. I have always loved collecting old books, and one of my favorite older poets is Edgar Allen Poe. My dad found …

تكامل الاستدامة في التخطيط الاستراتيجي لتحسين جودة المعلومات المحاسبية: دراسة تحليلية لعينة من المصارف في سوق العراق للأوراق المالية, حليم اسماعيل شنتة

Muthanna Journal of Administrative and Economics Sciences

يهدف هذا البحث إلى تحليل تأثير تكامل الاستدامة في التخطيط الاستراتيجي على جودة المعلومات المحاسبية في القطاع المصرفي، حيث تم اختيار عينة من المصارف في سوق العراق للأوراق المالية، وذلك لأنها تعد تقارير الاستدامة بشكل دوري، حيث اعتمد البحث على المنهج الوصفي التحليلي، وجمعت البيانات باستخدام استبانة وزعت على 110 المحاسبين والمدققين والمديرين الماليين في تلك المصارف والمحللين الماليين ، حيث تم استرجاع 93 استبانة صالحة للتحليل، بنسبة استجابة بلغت 84.5%، وقد ركزت الاستبانة على قياس تأثير تطبيق استدامة التخطيط الاستراتيجي على تحسين جودة المعلومات المحاسبية، مثل الشفافية والدقة والموثوقية، وأظهرت النتائج أن دمج مبادئ الاستدامة في التخطيط الاستراتيجي يعزز …

Environmentalism And Antitrust, Albert H. Choi, Daniel A. Crane

Law & Economics Working Papers

In recent years, there has been a proliferation of interest concerning environmental issues and the application of the antitrust laws. Numerous commentators, for instance, have argued that the antitrust enforcement should adjust to reflect the environmental harm (or benefit) that is generated from a competitive condition. In this paper, we take a step back and argue that analysis of the intersection between antitrust and environmentalism should begin with more mundane questions of economics. More specifically, we argue that environmental regulations can inform antitrust analysis by considering (at least) three issues: (1) the impact of environmental regulation on the firms' production …

Tax Delegation Post-Loper Bright, Reuven S. Avi-Yonah

Law & Economics Working Papers

In its recent decision in Loper Bright, the Supreme Court has fundamentally shifted the contours of judicial deference to administrative interpretations by repealing the Chevron doctrine. However, while the Court has curtailed deference, it simultaneously underscored the legitimacy of statutory delegation to agencies. The Internal Revenue Code (Code) is the most intricate legislative text within the U.S. legal framework, necessitating significant technical expertise for its application. It is, therefore, unsurprising that Congress often delegates authority to the IRS for the execution of the statute. In light of the Court's decision in Loper Bright, it becomes imperative to clarify the parameters …

Coopetition In Heterogeneous Cross-Silo Federated Learning, Chao Huang, Justin Dachille, Xin Liu

School of Computing Faculty Scholarship and Creative Works

In cross-silo federated learning (FL), companies collaboratively train a shared global model without sharing heterogeneous data. Prior related work focused on algorithm development to tackle data heterogeneity. However, the dual problem of coopetition, i.e., FL collaboration and market competition, remains under-explored. This paper studies the FL coopetition using a dynamic two-period game model. In period 1, an incumbent company trains a local model and provides model-based services at a chosen price to users. In period 2, an entrant company enters, and both companies decide whether to engage in FL collaboration and then compete in selling model-based services at different prices …

Bar Review Vendor Pop Up, New York Law School

Academic and Bar Success Initiatives

October 16, 2024

October 16, 2024 Blazer Weekly, University Of Alabama At Birmingham

Blazer Weekly (student newsletter)

No abstract provided.

2024-10-16 Sga Meeting Minutes, Morehead State University. Student Government Association.

Student Government Association Records

Meeting minutes of the Student Government Association from October 16, 2024.

Oregon State Rank Assessment For Warner Basin Tui Chub (Siphateles Bicolor Ssp. 15), Eleanor P. Gaines, Jesse Laney

Institute for Natural Resources Publications

Oregon state conservation status assessment for Warner Basin tui chub (Siphateles bicolor ssp. 15) using NatureServe methodology, 2024.

Sheng-Wen Cheng V. Attorney General United States Of America

2024 Decisions

USDC for the District of New Jersey

Lan Trinh V. Kathleen Trinh

2024 Decisions

USDC for the Eastern District of Pennsylvania

Gardner-Webb Athletics Hosts Teams From Uncasheville And Montreat Displaced By Helene, Office Of University Communications

Gardner-Webb NewsCenter Archive

Over the next few weeks, the Gardner-Webb University community might notice a few blue and white Bulldogs showing up around campus or even some blue, white and gold Cavaliers. These are the school colors and mascots for the University of North Carolina at Asheville and Montreat College. Both colleges have teams staying at Gardner-Webb.

Top Tier 2.0: Student Achievement, University Of Nevada, Las Vegas

Focus on Top Tier 2.0

Student Achievement is about our students who come to UNLV with the expectation that their experiences here will help improve their lives. Students are valued and their success is our mission. The work we do is vital as we prepare individuals for success in their personal, civic, and professional lives.

October 16, 2024 (Vol. 109, No. 8), Daily Eastern News

Daily Eastern News: 2024-2025

No abstract provided.

Rootzone Soil Moisture Dynamics Using Terrestrial Water-Energy Coupling, Vinit Sehgal, Binayak P. Mohanty, Rolf H. Reichle

Faculty Publications

A lack of high-density rootzone soil moisture (θRZ) observations limits the estimation of continental-scale, space-time contiguous θRZ dynamics. We derive a proxy of daily θRZ dynamics — active rootzone degree of saturation (SRZ) — by recursive low-pass (LP) filtering of surface soil moisture (θS) within a terrestrial water-energy coupling (WEC) framework. We estimate the LP filter parameters and WEC thresholds for the piecewise-linear coupling between SRZ and evaporative fraction (EF) at remote sensing and field scale over the Contiguous U.S. We use θS from the Soil Moisture Active-Passive (SMAP) satellite and 218 in-situ stations, with EF from the Moderate Resolution …

Contributions Of Speaking, Listening, And Semantic Depth To Word Learning In Typical 3- And 4-Year-Olds, Peter Richtsmeier, Allison Gladfelter, Michelle Moore

CISLL Publications

Purpose: This study examined learning via perception, learning via production, and semantic depth as contributors to word learning in preschool-aged children. There is broad evidence that semantic depth is an important contributor to word learning, especially when semantic cues are repeated and spaced out over time. Perceptual learning and production learning each support word learning sometimes, but not in all cases. The purpose of this study was to examine all three learning mechanisms within a single experimental paradigm.

Method: Thirty-six typically developing preschool children completed the experiment. They were familiarized with 16 novel words that were contextualized as alien names. …

Learning Delivery Methods And Basic Psychological Needs Satisfaction And Frustration: A Causal-Comparative Study, Tiffany Adora Cotterman

Doctoral Dissertations and Projects

The purpose of this quantitative, causal-comparative study was to determine if there is a difference among Instructor-led Training, Virtual Instructor-led Training, and Instructor-led Training with Autonomous Learning participants’ scores in autonomy satisfaction, autonomy frustration, relatedness satisfaction, relatedness frustration, competence satisfaction, and competence frustration. This study expounded upon the current knowledge of adult learning, including its effect on the six dimensions of basic psychological need satisfaction and frustration, and provided recommendations for future studies. A convenience sample of 123 newly hired Eastern Caribbean Business Process Outsourcing agents participating in a five-day onboard training were surveyed. Instrumentation consisted of the 24-item Basic …

A Phenomenological Study Examining Lived Experiences Of Persistent Non-Traditional Students With Learning Disabilities At Community College, Mary Elizabeth Regis

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to understand the lived experiences of persistent non-traditional community college students with learning disabilities at community colleges in the Midwest United States. For this study, persistent, non-traditional community college students are defined as students who completed their first year of college, were currently enrolled in their second year of college or earned more than 30 credits, and were 25 or older, with commitments in addition to their academics, College students with learning disabilities were defined as students who had a documented learning disability rather than self-identified diagnoses. Ryan and Deci’s self-determination theory …

A Phenomenological Study Of Novice Special Education Teachers' Experience Applying Causal Attributions To Challenging Behavior, Mandy Marie Augst

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe novice special education teachers’ experiences attributing causes to challenging behaviors in U.S. public schools. This study was guided by Bernard Weiner’s attribution theory of motivation. This framework allowed for the examination of teachers’ causal attributions for challenging behavior as well as their personal motivation in responding to challenging behaviors. This study's central research question focused on novice special education teachers’ experiences attributing causes to challenging behavior. The researcher employed a transcendental phenomenological approach, engaging participants as co-researchers to understand their lived experiences. A sample of 11 participants was recruited from …