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Architecting Standards: Leveraging Ia To Drive Emerging Technology Standards​, Noreen Y. Whysel

Publications and Research

In this talk for the annual meeting of the W3C Information Architecture Community Group, I discuss how standards bodies can learn from the Information Architecture field to improve accessibility and usability. By adopting user-centered design principles and engaging in iterative feedback loops, standards organizations can create more relevant and practical standards that align with real-world applications. Emphasizing collaboration with industry experts and end-users will help ensure that standards evolve along with technological advancements.

In the meantime, key standards are examined, such as ISO 9241, which provides guidelines for usability and user-centered design, and the W3C's Web Content Accessibility Guidelines (WCAG), …

Immunomodulation Of Macrophages In Diabetic Wound Individuals By Structurally Diverse Bioactive Phytochemicals, Krishnendu Adhikary, Riya Sarkar, Sriparna Maity, Ishani Sadhukhan, Riya Sarkar, Krishnendu Ganguly, Saurav Barman, Rajkumar Maiti, Sanjoy Chakraborty, Tandra R. Chakraborty, Debasis Bagchi, Pradipta Banerjee

Publications and Research

Diabetes-related ulcers and slow-healing wounds pose a significant health risk to individuals due to their uncertain causes. Mortality rates for diabetes foot ulcers (DFUs) range from 10% after 16 months to 24% after five years. The use of bioactive phytochemicals can play a key role in healing wounds in a predictable time. Recent literature has demonstrated that various natural substances, including flavonoids, saponins, phenolic compounds, and polysaccharides, play key roles at different stages of the wound-healing process through diverse mechanisms. These studies have categorized the compounds according to their characteristics, bioactivities, and modes of action. In this study, we evaluated …

Urinary Tract Infection Caused By Gardnerella Vaginalis In A 6 Week Old Infant, Rhythm Sharma, Malika Goel, Ruba Barbar

Conference Presentation Abstracts

Introduction: Gardnerella vaginalis is a frequent cause of bacterial vaginosis (BV) in adults. However, G. vaginalis infection is infrequent in infants. Only a few cases of G. vaginalis UTI have been reported so far in infants and none in the United States.

Case Description: A 6-week-old female, ex full-term at 39 3/7 weeks via vaginal delivery with no significant postnatal medical history, presented with a 2-day history of fever, mild cough, and congestion.

In the emergency department, the patient was febrile to 38.1°C, pulse 139 beats/minute, respiratory rate 34 breaths/minute, and SpO2 98% on room air. She was active and …

In Vitro Profiling Of The Antiviral Peptide Tat-I24, Theodhora Ziu, Ezgi Sambur, Zsolt Ruzsics, Hartmut Hengel, Reingard Grabherr, Siegfried Hofinger, Hanna Harant

Michigan Tech Publications

The synthetic peptide TAT-I24 (GRKKRRQRRRPPQCLAFYACFC) exerts antiviral activity against several double-stranded (ds) DNA viruses, including herpes simplex viruses, cytomegalovirus, some adenoviruses, vaccinia virus and SV40 polyomavirus. In the present study, in vitro profiling of this peptide was performed with the aim of characterizing and improving its properties for further development. As TAT-I24 contains three free cysteine residues, a potential disadvantageous feature, peptide variants with replacements or deletions of specific residues were generated and tested in various cell systems and by biochemical analyses. Some cysteine replacements had no impact on the antiviral activity, such as the deletion of cysteine 14, which …

Mr. Calvin Muriel Johnson

African American Funeral Programs

No abstract provided.

Zhong-Qun Tian, Academician And Honorary Member Of Electrochemistry Committee Chinese Chemical Society, Achieved "Raman Lifetime Award", Editorial Office Of J.Electrochem.

Journal of Electrochemistry

No abstract provided.

Optimization Of Channel Structure Of Alkaline Water Electrolyzer By Using An Expanded Mesh As A Bipolar Plate, Hai-Yan Xiong, Zhen-Xiao Zhu, Xin Gao, Chen-Ming Fan, Hui-Bao Luan, Bing Li

Journal of Electrochemistry

Alkaline water electrolysis (AWE) is the most mature technology for hydrogen production by water electrolysis. Alkaline water electrolyzer consists of multiple electrolysis cells, and a single cell consists of a diaphragm, electrodes, bipolar plates and end plates, etc. The existing industrial bipolar plate channel is concave-convex structure, which is manufactured by complicated and high-cost mold punching. This structure still results in uneven electrolyte flow and low current density in the electrolytic cell, further increasing in energy consumption and cost of AWE. Thereby, in this article, the electrochemical and flow model is firstly constructed, based on the existing industrial concave and …

Chinese Chemical Society: First Young Scholars' Symposium On Electrosynthesis Held Successfully, Chinese Society Of Electrochemistry (Cse)

Journal of Electrochemistry

No abstract provided.

2024 Tianmulake Advanced Anode Materials Innovation Forum And Sixth National Conference Of Advanced Battery Failure Analysis And Testing Technology Concluded Successfully, Editorial Office Of J.Electrochem.

Journal of Electrochemistry

No abstract provided.

Electronic Communication Between Co And Ru Sites Decorated On Nitrogen-Doped Carbon Nanotubes Boost The Alkaline Hydrogen Evolution Reaction, Meng-Ting Gao, Ying Wei, Xue-Meng Hu, Wenj-Jie Zhu, Qing-Qing Liu, Jin-Yuan Qiang, Wan-Wan Liu, Ying Wang, Xu Li, Jian-Feng Huang, Yong-Qiang Feng

Journal of Electrochemistry

Designing highly efficient Pt-free electrocatalysts with low overpotential for an alkaline hydrogen evolution reaction (HER) remains a significant challenge. Here, a novel and efficient cobalt (Co), ruthenium (Ru) bimetallic electrocatalyst composed of CoRu nanoalloy decorated on the N-doped carbon nanotubes (CoRu@N-CNTs), was prepared by reacting fullerenol with melamine via hydrothermal treatment and followed by pyrolysis. Benefiting from the electronic communication between Co and Ru sites, the as-obtained CoRu@N-CNTs catalyst exhibited superior electrocatalytic HER activity. To deliver a current density of 10 mA·cm^–2, it required an overpotential of merely 19 mV along with a Tafel slope of 26.19 mV·dec …

Aging Characteristics Of Lithium-Ion Battery Under Fast Charging Based On Electrochemical-Thermal-Mechanical Coupling Model, Dong-Xu Zuo, Pei-Chao Li

Journal of Electrochemistry

The aging characteristics of lithium-ion battery (LIB) under fast charging is investigated based on an electrochemical-thermal-mechanical (ETM) coupling model. Firstly, the ETM coupling model is established by COMSOL Multiphysics. Subsequently, a long cycle test was conducted to explore the aging characteristics of LIB. Specifically, the effects of charging (C) rate and cycle number on battery aging are analyzed in terms of nonuniform distribution of solid electrolyte interface (SEI), SEI formation, thermal stability and stress characteristics. The results indicate that the increases in C rate and cycling led to an increase in the degree of nonuniform distribution of SEI, and thus …

Generating Assignments In Science Methods Using Research-Based Transparency: Challenging Preservice Teachers To Do Likewise, University Of Northern Iowa, Crystal Bruxvoort

University Faculty Publications and Creative Works

North Central-Association for Science Teacher Education (NC-ASTE) regional meeting

A Case Of Acquired Cystic Kidney Disease From Chronic Renal Failure Without Dialysis, Emily Quintero, Kebir Bedran

All Publications

The kidneys play a vital role in maintaining homeostasis by filtering the blood of waste products and toxins, maintaining a delicate balance of fluids and electrolytes, and closely regulating blood pressure via the juxtaglomerular apparatus. Cystic kidney disease is a pathology of the kidneys that can be either acquired or congenital. This case report introduces a seventy-eight-year-old male with a medical history of a myocardial infarction and heart valve replacements who presented to the emergency department due to a recent fall at home unrelated to syncope. As he rose from his chair, the patient fell forward but was able to …

Inorganic Polyphosphate Promotes Colorectal Cancer Growth Via Trpm8 Receptor Signaling Pathway, Valentina Arrè, Chen Shen, Et Al.

2020-Current year OA Pubs

BACKGROUND: Colorectal cancer (CRC) is characterized by a pro-inflammatory microenvironment and features high-energy-supply molecules that assure tumor growth. A still less studied macromolecule is inorganic polyphosphate (iPolyP), a high-energy linear polymer that is ubiquitous in all forms of life. Made up of hundreds of repeated orthophosphate units, iPolyP is essential for a wide variety of functions in mammalian cells, including the regulation of proliferative signaling pathways. Some evidence has suggested its involvement in carcinogenesis, although more studies need to be pursued. Moreover, iPolyP regulates several homeostatic processes in animals, spanning from energy metabolism to blood coagulation and tissue regeneration.

RESULTS: …

Nanopore Signal Deviations From Pseudouridine Modifications In Rna Are Sequence-Specific: Quantification Requires Dedicated Synthetic Controls, Amr Makhamreh, Sepideh Tavakoli, Ali Fallahi, Xinqi Kang, Howard Gamper, Mohammad Nabizadehmashhadtoroghi, Miten Jain, Ya-Ming Hou, Sara H Rouhanifard, Meni Wanunu

Department of Biochemistry and Molecular Biology Faculty Papers

Chemical modifications to mRNA respond dynamically to environmental cues and are important modulators of gene expression. Nanopore direct RNA sequencing has been applied for assessing the presence of pseudouridine (ψ) modifications through basecalling errors and signal analysis. These approaches strongly depend on the sequence context around the modification, and the occupancies derived from these measurements are not quantitative. In this work, we combine direct RNA sequencing of synthetic RNAs bearing site-specific modifications and supervised machine learning models (ModQuant) to achieve near-analytical, site-specific ψ quantification. Our models demonstrate that the ionic current signal features important for accurate ψ classification are sequence …

Broad Applicability Of The Goldspire™ Platform For The Treatment Of Solid Tumors, Jenny Zilberberg, Christopher Uhl, Charles B Scott, David W. Andrews, Mark A Exley

Department of Neurosurgery Faculty Papers

Goldspire™ is a personalized immunotherapy platform that combines whole tumor-derived cells with antisense oligonucleotide (IMV-001) against Insulin-Like Growth Factor-1 Receptor (IGF-1R) in biodiffusion chambers (BDCs; 0.1 μm pore). BDCs are exposed to 5-6 Gy and implanted at abdominal sites for ∼48 h to deliver an antigenic payload and immunostimulatory factors to train the immune system. Lead product IGV-001 was evaluated in newly diagnosed glioblastoma (ndGBM) patients in Phase 1a and 1b trials (NCT02507583). A Phase 2b study (NCT04485949) recently completed enrollment. Preventative treatment with tumor-specific products manufactured with Goldspire limited tumor progression and extended overall survival in mice challenged with …

A Multicenter, Randomized, Non-Comparative, Phase Ii Study Of Nivolumab ± Ipilimumab For Patients With Metastatic Sarcoma (Alliance A091401): Expansion Cohorts And Correlative Analyses, Nathan D Seligson, James L Chen, Austin C Goodrich, Brian A Van Tine, Jordan D Campbell, Allison L Richards, Cristina R Antonescu, David A Liebner, Mohammed M Milhem, Howard Streicher, William D Tap, Gary K Schwartz, Suzanne George, Sandra P D'Angelo

2020-Current year OA Pubs

BACKGROUND: In this open-label, randomized, non-comparative, multicenter phase II study (Alliance A091401) we report on three expansion cohorts treated with nivolumab (N) with and without ipilimumab (N+I) and provide a multi-omic correlative analysis of actionable biomarkers.

METHODS: Patients were randomized (non-comparative) to receive either N or N+I. The primary endpoint was a 6-month confirmed response rate (CRR) defined by Response Evaluation Criteria in Solid Tumors version 1.1. Secondary endpoints included treatment-related adverse events (TRAEs), progression-free survival, and overall survival. Multi-omic correlative analyses were conducted using samples from both the primary and expansion cohorts.

RESULTS: A total of 66 patients were …

Safety Of Dostarlimab In Combination With Chemotherapy In Patients With Primary Advanced Or Recurrent Endometrial Cancer In A Phase Iii, Randomized, Placebo-Controlled Trial (Engot-En6-Nsgo/Gog-3031/Ruby), Annika Auranen, Matthew A Powell, Et Al.

2020-Current year OA Pubs

BACKGROUND: In Part 1 of the phase III RUBY trial (NCT03981796) in patients with primary advanced or recurrent endometrial cancer (EC), dostarlimab plus carboplatin-paclitaxel (CP) significantly improved progression-free survival and overall survival compared with CP alone. Limited safety data have been reported for the combination of immunotherapies plus chemotherapy in this setting.

OBJECTIVES: The objective of this analysis was to identify the occurrence of treatment-related adverse events (TRAEs) and immune-related adverse events (irAEs) and to describe irAE management in Part 1 of the RUBY trial.

DESIGN: RUBY is a phase III, randomized, double-blind, multicenter study of dostarlimab plus CP compared …

How To Utilize Current Guidelines To Manage Patients With Cancer At High Risk For Heart Failure, Michelle Bloom, Jose A Alvarez-Cardona, Sarju Ganatra, Ana Barac, Iskra Pusic, Daniel Lenihan, Susan Dent

2020-Current year OA Pubs

Heart failure (HF) in patients with cancer is associated with high morbidity and mortality. The success of cancer therapy has resulted in an exponential rise in the population of cancer survivors, however cardiovascular disease (CVD) is now a major life limiting condition more than 5 years after cancer diagnosis [Sturgeon, Deng, Bluethmann, et al 40(48):3889-3897, 2019]. Prevention and early detection of CVD, including cardiomyopathy (CM) and HF is of paramount importance. The European Society of Cardiology (ESC) published guidelines on Cardio-Oncology (CO) [Lyon, López-Fernández, Couch, et al 43(41):4229-4361, 2022] detailing cardiovascular (CV) risk stratification, prevention, monitoring, diagnosis, and treatment throughout …

Cover And Forewords, Steven M. Schnell

The Geographical Bulletin

Cover and Forewords

Volume 55-1 Complete Issue, Steven M. Schnell

The Geographical Bulletin

Volume 55-1 Complete Issue

Short-Term Associations Between Accumulated Rainfall And Atmospheric Moisture During Landfall Of Three Atlantic Hurricanes, Peng Jia, Andrew Joyner, Yilun Sun

The Geographical Bulletin

Most hurricane-related deaths are caused by flooding and, as a result, accurate forecasting of rainfall can have a profound impact on reducing loss of life as well as property damages resulting from hurricanes. Quantitative relationships between atmospheric moisture and rainfall have been examined during the landfall of three Atlantic hurricanes in the study, with Geographic Information System and high temporal resolution remote sensing data used and time lags between atmospheric moisture and rainfall taken into account. Results show that 1) atmospheric moisture and rainfall-related variables can be accurately gauged by satellite at any given place and provide approximate estimations for …

Assessing Land Use Changes Due To Natural Gas Drilling Operations In The Marcellus Shale In Bradford County, Pa, Claire A. Jantz, Hannah K. Kubach, Jacob R. Ward, Shawn Wiley, Dana Heston

The Geographical Bulletin

Extraction of natural gas from the Marcellus Shale formation began in the mid-2000s, and well pads and their associated infrastructure are now prominent fixtures throughout the Appalachian region. However, there is currently little research available to provide insight into its implications for land use and land cover change. In this case study of Bradford County, Pennsylvania, we used high-resolution aerial photography, land cover data, and well point data to quantify current and potential land use change as a result of gas drilling, as well as the types of land cover to be converted. Based on the number of permits held …

Mapping Burn Severity Using The Composite Burn Index In An Oak Savannah In Central Massachusetts, Joseph Danko Iii, John Rogan, Dominik Kulakowski, Maureen Mcconnell

The Geographical Bulletin

The goal of this paper is to characterize the spatial variability in burn severity of a wildfire in an oak savannah within the wildland-urban interface in Worcester, Massachusetts using the Composite Burn Index (CBI). This work compares two interpolated surfaces of burn severity values collected in a March 2012 burn area and examines the statistical relationship between burn severity (CBI), fuel type and topography. The wildfire burned at low-to-medium severity (0.1 – 2.0 CBI). Burn severity was highest in mixed grass and shrub fuels beneath oak canopy cover (mean 1.11 CBI), followed by open-canopy shrub fuels (mean 1.09 CBI) and …

Local Regulatory Protection For Ecosystem Services: A Case Study From The Karst Region Of Southeast Minnesota, Usa, Mary A. Williams, Susy Svatek Ziegler

The Geographical Bulletin

Human communities depend upon a myriad of ecosystem goods and services, which are produced by and depend on natural environmental processes occurring at multiple temporal and spatial scales. Land-use policy seldom recognizes the importance of these services or the environmental processes generating these services. This study examined the degree to which ecosystem services and supporting environmental processes are regulated at two United States municipal levels: city and county. Several ecosystem services but few environmental processes are regulated to some extent. We identified policy needs for environmentally sensitive karst features, aquifer recharge, groundwater quality, plant and animal populations, and flood mitigation. …

Cover And Forewords, Steven M. Schnell

The Geographical Bulletin

Cover and Forewords

Volume 54-2 Complete Issue, Steven M. Schnell

The Geographical Bulletin

Volume 54-2 Complete Issue

Geography And The Emergence Of Sustainability Science: Missed Opportunities And Enduring Possibilities, Drew E. Bennett

The Geographical Bulletin

The dawn of the 21st century saw the emergence of the newly declared field of “sustainability science.” The new field’s research agenda focuses on meeting human needs while simultaneously sustaining the life support systems of the planet. The field works to merge the natural and social sciences with analyses conducted from global to local scales. Sustainability science resembles the long-standing human-environment tradition in geography, yet geography was not widely recognized as a fundamental discipline during the emergence of sustainability science. The failure of geography to exert itself in the birth of sustainability science is the latest failure by geography to …

Crime Modeling And Mapping Using Geospatial Technologies Crime Modeling And Mapping Using Geospatial Technologies, Edited By Michael Leitner Springer, Charlie Zhang

The Geographical Bulletin

Crime mapping and spatial analysis of crime remains one of the most active fields regarding the applications of geospatial technologies. Included in the book series of Geotechnologies and Environment by Springer, Crime modeling and Mapping Using Geospatial Technologies, edited by Michael Leitner, presents a rich collection of the latest research applying cutting edge geo-techniques to crime mapping and spatial analysis of crime. This book is made up of eighteen chapters which cover a broad range of topics such as spatial analysis of drug market areas, spatiotemporal clustering of crime hot spots, journey to crime, and campus crime. Whereas most chapters …

Facebook As A Way Oflife: Louis Wirth In Thesocial Network, Larissa Zip, Rebekah Parker, Elvin Wyly

The Geographical Bulletin

The rise of social networking practices has inspired widespread public debate and scholarly attention: a growing share of social relations began to take place online in the virtual worlds of social media sites at the same time that the ‘real’ world became majority-urban. What are the implications of these trends for how we understand the geography of urban society? In this paper, we re-engage one of the foundational contributions of twentieth-century Chicago School sociology, Louis Wirth’s article “Urbanism as a Way of Life,” (1938) to understand the socio-spatial implications of social media in an era of planetary urbanization. A growing …