Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 299191 - 299220 of 5165602

Full-Text Articles in Entire DC Network

Publisher Correction: Detection Of Mosaic And Population-Level Structural Variants With Sniffles2, Moritz Smolka, Luis F Paulin, Christopher M Grochowski, Dominic W Horner, Medhat Mahmoud, Sairam Behera, Ester Kalef-Ezra, Mira Gandhi, Karl Hong, Davut Pehlivan, Sonja W Scholz, Claudia M B Carvalho, Christos Proukakis, Fritz J Sedlazeck Oct 2024

Publisher Correction: Detection Of Mosaic And Population-Level Structural Variants With Sniffles2, Moritz Smolka, Luis F Paulin, Christopher M Grochowski, Dominic W Horner, Medhat Mahmoud, Sairam Behera, Ester Kalef-Ezra, Mira Gandhi, Karl Hong, Davut Pehlivan, Sonja W Scholz, Claudia M B Carvalho, Christos Proukakis, Fritz J Sedlazeck

Faculty, Staff and Students Publications

This corrects the article "Detection of mosaic and population-level structural variants with Sniffles2" on page 1571.


Polycaprolactone-Based Shape Memory Foams As Self-Fitting Vaginal Stents, Ashley J Hicks, Courteney Roberts, Andrew Robinson, Kailey Wilson, Varsha Kotamreddy, Trace Larue, Arian Veyssi, Felipe Beltran, Julie Hakim, Manuel K Rausch, Melissa Grunlan, Elizabeth Cosgriff-Hernandez Oct 2024

Polycaprolactone-Based Shape Memory Foams As Self-Fitting Vaginal Stents, Ashley J Hicks, Courteney Roberts, Andrew Robinson, Kailey Wilson, Varsha Kotamreddy, Trace Larue, Arian Veyssi, Felipe Beltran, Julie Hakim, Manuel K Rausch, Melissa Grunlan, Elizabeth Cosgriff-Hernandez

Faculty, Staff and Students Publications

There is an urgent critical need for a patient-forward vaginal stent that can prevent debilitating vaginal stenosis that occurs after pelvic radiation treatments and vaginal reconstruction. To this end, we developed a self-fitting vaginal stent based on a shape-memory polymer (SMP) foam that can assume a secondary, compressed shape for ease of deployment. Upon insertion, the change in temperature and hydration initiates foam expansion to shape fit to the individual patient and restore the lumen of the stent to allow egress of vaginal secretions. To achieve rapid actuation at physiological temperature, we investigated the effect of architecture of two photocurable, …


Circulating Blood Plasma Profiling Reveals Proteomic Signature And A Causal Role For Svep1 In Sudden Cardiac Death, Thuyvy Duong, Thomas R Austin, Jennifer A Brody, Ali Shojaie, Alexis Battle, Joel S Bader, Yun Soo Hong, Christie M Ballantyne, Josef Coresh, Robert E Gerszten, Russell P Tracy, Bruce M Psaty, Nona Sotoodehnia, Dan E Arking Oct 2024

Circulating Blood Plasma Profiling Reveals Proteomic Signature And A Causal Role For Svep1 In Sudden Cardiac Death, Thuyvy Duong, Thomas R Austin, Jennifer A Brody, Ali Shojaie, Alexis Battle, Joel S Bader, Yun Soo Hong, Christie M Ballantyne, Josef Coresh, Robert E Gerszten, Russell P Tracy, Bruce M Psaty, Nona Sotoodehnia, Dan E Arking

Faculty, Staff and Students Publications

No abstract provided.


The Fallacy Of Electronic Cigarettes For Tobacco Dependence, Harold J Farber, Carlos Rábade Castedo, Carlos A Jimenez-Ruiz, Manuel Conrado Pacheco Oct 2024

The Fallacy Of Electronic Cigarettes For Tobacco Dependence, Harold J Farber, Carlos Rábade Castedo, Carlos A Jimenez-Ruiz, Manuel Conrado Pacheco

Faculty, Staff and Students Publications

No abstract provided.


Anger Outbursts In Youth With Asd And Anxiety: Phenomenology And Relationship With Family Accommodation, Allie N Townsend, Andrew G Guzick, Alyssa G Hertz, Connor M Kerns, Wayne K Goodman, Leandra N Berry, Philip C Kendall, Jeffrey J Wood, Eric A Storch Oct 2024

Anger Outbursts In Youth With Asd And Anxiety: Phenomenology And Relationship With Family Accommodation, Allie N Townsend, Andrew G Guzick, Alyssa G Hertz, Connor M Kerns, Wayne K Goodman, Leandra N Berry, Philip C Kendall, Jeffrey J Wood, Eric A Storch

Faculty, Staff and Students Publications

Anger outbursts (AO) are associated with severe symptoms, impairment and poorer treatment outcomes for anxious children, though limited research has examined AO in youth with co-occurring autism and anxiety disorders. This study examined AO in children with autism and anxiety by evaluating clinical characteristics, family accommodation, and changes in AO following anxiety-focused treatment. The sample comprised 167 youth with autism and anxiety enrolled in a multi-site randomized clinical trial comparing standard care CBT for anxiety, CBT adapted for youth with autism, and usual care. Most participants (60%) had AO, which contributed to impairment above and beyond anxiety and autism. AO …


Multifocal Retinocytoma Associated With Intronic Acceptor Splice Site Variants In The Rb1 Gene, Jennifer Li-Wang, Patricia Chévez-Barrios, Jessica S Thomas, Amy C Schefler Oct 2024

Multifocal Retinocytoma Associated With Intronic Acceptor Splice Site Variants In The Rb1 Gene, Jennifer Li-Wang, Patricia Chévez-Barrios, Jessica S Thomas, Amy C Schefler

Faculty, Staff and Students Publications

Retinocytomas are benign tumors that arise from mutations in the RB1 gene. Previous research describes the appearance of retinocytomas as that of treated retinoblastoma (Rb) lesions, with characteristics such as chorioretinal atrophy, calcification, and a lack of necrosis or mitotic activity on histopathology. We present the unusual case of an asymptomatic seven-year-old girl with two independent translucent masses in the peripheral retina of the right eye (OD) and extensive intraretinal tumor and vitreous seeds. Initial fundus examination and B-scan ultrasonography documented the two lesions with extensive placoid intraretinal tumor, uncalcified vitreous seeds, and an area of large subhyaloid seed on …


Novel Genes Of The Male Reproductive System: Potential Roles In Male Reproduction And As Non-Hormonal Male Contraceptive Targets, Thomas X Garcia, Martin M Matzuk Oct 2024

Novel Genes Of The Male Reproductive System: Potential Roles In Male Reproduction And As Non-Hormonal Male Contraceptive Targets, Thomas X Garcia, Martin M Matzuk

Faculty, Staff and Students Publications

The development of novel non-hormonal male contraceptives represents a pivotal frontier in reproductive health, driven by the need for safe, effective, and reversible contraceptive methods. This comprehensive review explores the genetic underpinnings of male fertility, emphasizing the crucial roles of specific genes and structural variants (SVs) identified through advanced sequencing technologies such as long-read sequencing (LRS). LRS has revolutionized the detection of structural variants and complex genomic regions, offering unprecedented precision and resolution over traditional next-generation sequencing (NGS). Key genetic targets, including those implicated in spermatogenesis and sperm motility, are highlighted, showcasing their potential as non-hormonal contraceptive targets. The review …


Dsm-5 Criterion-A-Based Trauma Types In Service Members And Veterans Seeking Treatment For Posttraumatic Stress Disorder, Natasha Benfer, Breanna Grunthal, Katherine A Dondanville, Stacey Young-Mccaughan, Abby Blankenship, Chadi G Abdallah, Sudie E Back, Julianne Flanagan, Edna B Foa, Peter T Fox, John H Krystal, Brian P Marx, Donald D Mcgeary, Carmen P Mclean, Kristi E Pruiksma, Patricia A Resick, John D Roache, Paulo Shiroma, Denise M Sloan, Daniel J Taylor, Jennifer Schuster Wachen, Argelio L López-Roca, Karin L Nicholson, Richard P Schobitz, Christian C Schrader, Allah-Fard M Sharrieff, Jeffrey S Yarvis, Jim Mintz, Terence M Keane, Alan L Peterson, Brett T Litz Oct 2024

Dsm-5 Criterion-A-Based Trauma Types In Service Members And Veterans Seeking Treatment For Posttraumatic Stress Disorder, Natasha Benfer, Breanna Grunthal, Katherine A Dondanville, Stacey Young-Mccaughan, Abby Blankenship, Chadi G Abdallah, Sudie E Back, Julianne Flanagan, Edna B Foa, Peter T Fox, John H Krystal, Brian P Marx, Donald D Mcgeary, Carmen P Mclean, Kristi E Pruiksma, Patricia A Resick, John D Roache, Paulo Shiroma, Denise M Sloan, Daniel J Taylor, Jennifer Schuster Wachen, Argelio L López-Roca, Karin L Nicholson, Richard P Schobitz, Christian C Schrader, Allah-Fard M Sharrieff, Jeffrey S Yarvis, Jim Mintz, Terence M Keane, Alan L Peterson, Brett T Litz

Faculty, Staff and Students Publications

Objective: In posttraumatic stress disorder (PTSD), the assumption of the equipotentiality of traumas ignores potentially unique contexts and consequences of different traumas. Accordingly, Stein et al. (2012) developed a reliable typing scheme in which assessors categorized descriptions of traumatic events into six "types": life threat to self (LTS), life threat to other, aftermath of violence (AV), traumatic loss, moral injury by self (MIS), and moral injury by other (MIO). We extended this research by validating the typing scheme using participant endorsements of type, rather than assesor-based types. We examined the concordance of participant and assesor types, frequency, and validity …


Dedication Of The Henry B. Peters Building, 1994, Uab Archives Oct 2024

Dedication Of The Henry B. Peters Building, 1994, Uab Archives

Images of the Month from UAB Archives

Image ID: PMC104, #0277

Henry B. Peters, OD, at the dedication of UAB's Peters Building, 1994


Association Of Aortic Valve Calcium With Dementia And Stroke: The Multi-Ethnic Study Of Atherosclerosis, Natalie Marrero, Kunal Jha, Timothy M Hughes, Alexander C Razavi, Jelani K Grant, Ellen Boakye, Khalil Anchouche, Omar Dzaye, Matthew J Budoff, Jerome I Rotter, Xiuqing Guo, Jie Yao, Alexis C Wood, Roger S Blumenthal, Erin D Michos, George Thanassoulis, Wendy S Post, Michael J Blaha, Chinwe Ibeh, Seamus P Whelton Oct 2024

Association Of Aortic Valve Calcium With Dementia And Stroke: The Multi-Ethnic Study Of Atherosclerosis, Natalie Marrero, Kunal Jha, Timothy M Hughes, Alexander C Razavi, Jelani K Grant, Ellen Boakye, Khalil Anchouche, Omar Dzaye, Matthew J Budoff, Jerome I Rotter, Xiuqing Guo, Jie Yao, Alexis C Wood, Roger S Blumenthal, Erin D Michos, George Thanassoulis, Wendy S Post, Michael J Blaha, Chinwe Ibeh, Seamus P Whelton

Faculty, Staff and Students Publications

Background and aims: Calcific aortic valve disease is associated with increased thrombin formation, platelet activation, decreased fibrinolysis, and subclinical brain infarcts. We examined the long-term association of aortic valve calcification (AVC) with newly diagnosed dementia and incident stroke in the Multi-Ethnic Study of Atherosclerosis (MESA).

Methods: AVC was measured using non-contrast cardiac CT at Visit 1. We examined AVC as a continuous (log-transformed) and categorical variable (0, 1-99, 100-299, ≥300). Newly diagnosed dementia was adjudicated using International Classification of Disease codes. Stroke was adjudicated from medical records. We calculated absolute event rates (per 1000 person-years) and multivariable adjusted Cox proportional …


The Cultural Role Of Rice Cultivation In Female Workforce Participation In India, Gautam Hazarika Oct 2024

The Cultural Role Of Rice Cultivation In Female Workforce Participation In India, Gautam Hazarika

School of Economics and Finance Faculty Publications

Rice and wheat are India's staple cereal crops and there is significant regional variation in the suitability to the cultivation of each. Both are so-called ‘plough-positive’ crops, whose cultivation is benefited by ploughing. It has previously been argued that the ancient adoption of the plough, a heavy implement better suited to handling by men, was a factor in the evolution of cultural norms prescribing a domestic role for women in society (Boserup, 1970). This study contends that rice is an anomalous plough-positive crop in that its cultivation, highly labor-intensive, has traditionally required much female labor. This, it is argued, may …


The Relationship Of Acculturation With The Health Numeracy And Associated Health Behaviors Of Filipino-Americans, Ashwini Wagle, J. Cuaresma, Giselle A.P. Pignotti Oct 2024

The Relationship Of Acculturation With The Health Numeracy And Associated Health Behaviors Of Filipino-Americans, Ashwini Wagle, J. Cuaresma, Giselle A.P. Pignotti

Faculty Research, Scholarly, and Creative Activity

Describe relationships between acculturation level and the following variables - dietary acculturation and intake, health numeracy, physical activity, and anthropometric measurements - among Filipino-American men and women.


Self-Management, Attitudes, And Barriers For Students With Common Food Allergies Utilizing Campus Dining At A Large Urban University, Samantha Dahlberg, Ashwini Wagle, Jacqueline Bergman Oct 2024

Self-Management, Attitudes, And Barriers For Students With Common Food Allergies Utilizing Campus Dining At A Large Urban University, Samantha Dahlberg, Ashwini Wagle, Jacqueline Bergman

Faculty Research, Scholarly, and Creative Activity

Food allergies are associated with stress and anxiety in college students. This research study aims to explore the findings of students with known food allergies and their perspectives on how one large urban university campus dining service accommodates their dietary needs. The study utilized a mixed-methods approach, and a non-probability, purposive sampling was used for a campus-wide online self-reported survey from August to October 2023. The survey included twenty close-ended and open-ended questions about the student’s food allergy attitudes, self-management, and barriers to on-campus dining services. Participants were students who self-identified with a medically diagnosed food allergy or intolerance and …


Meta-Analysis Comparing Oral Anticoagulant Monotherapy Versus Dual Antithrombotic Therapy In Patients With Atrial Fibrillation And Stable Coronary Artery Disease, Mushood Ahmed, Areeba Ahsan, Aimen Shafiq, Raheel Ahmed, Mahboob Alam, Pierre Sabouret, Jamal S Rana, Gregg C Fonarow Oct 2024

Meta-Analysis Comparing Oral Anticoagulant Monotherapy Versus Dual Antithrombotic Therapy In Patients With Atrial Fibrillation And Stable Coronary Artery Disease, Mushood Ahmed, Areeba Ahsan, Aimen Shafiq, Raheel Ahmed, Mahboob Alam, Pierre Sabouret, Jamal S Rana, Gregg C Fonarow

Faculty, Staff and Students Publications

BACKGROUND: Oral anticoagulants (OACs) are routinely used for the management of atrial fibrillation (AF) while antiplatelet agents are used in coronary artery disease (CAD). However, data regarding the comparative clinical outcomes of OAC monotherapy versus dual antithrombotic therapy (anticoagulant plus antiplatelet agent) in patients with AF and stable CAD are limited.

METHODS: A comprehensive search of major databases including PubMed/MEDLINE, Cochrane Library, and Embase was performed from inception to September 1, 2024 to identify randomized control trials (RCTs) that compared OAC monotherapy with dual antithrombotic therapy in patients with AF and stable CAD. The risk ratios (RRs) were estimated with …


Resistance To Acetyl Coenzyme A Carboxylase (Accase) Inhibitor In Lolium Multiflorum: Effect Of Multiple Target-Site Mutations, Gulab Rangani, Ana Claudia Langaro, Shilpi Agrawal, Reiofeli Algodon Salas-Perez, Juan Camilo Velasquez, Christopher E. Nelson, Nilda Roma-Burgos Oct 2024

Resistance To Acetyl Coenzyme A Carboxylase (Accase) Inhibitor In Lolium Multiflorum: Effect Of Multiple Target-Site Mutations, Gulab Rangani, Ana Claudia Langaro, Shilpi Agrawal, Reiofeli Algodon Salas-Perez, Juan Camilo Velasquez, Christopher E. Nelson, Nilda Roma-Burgos

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Italian ryegrass (Lolium multiflorum Lam.) is a persistent weed species that poses significant management challenges in key agricultural crops such as wheat, corn, cotton, and soybean. This study investigated the prevalence of resistance to ACCase inhibitor herbicides, specifically diclofop and pinoxaden, among field-collected Italian ryegrass populations. The survey revealed widespread resistance to diclofop and emerging cross-resistance to pinoxaden. To elucidate the physiological mechanism of ACCase herbicide resistance, we investigated mutations in the carboxyl-transferase (CT) domain of the ACCase enzyme, a critical region for herbicide sensitivity. Using dCAPS assays and CT domain sequencing, several known resistance-conferring mutations were detected in …


A Virtual Breakthrough Series Collaborative For Missed Test Results: A Stepped-Wedge Cluster-Randomized Clinical Trial, Lisa Zubkoff, Andrew J Zimolzak, Ashley N D Meyer, Jennifer Sloane, Umber Shahid, Traber Giardina, Sahar A Memon, Taylor M Scott, Daniel R Murphy, Hardeep Singh Oct 2024

A Virtual Breakthrough Series Collaborative For Missed Test Results: A Stepped-Wedge Cluster-Randomized Clinical Trial, Lisa Zubkoff, Andrew J Zimolzak, Ashley N D Meyer, Jennifer Sloane, Umber Shahid, Traber Giardina, Sahar A Memon, Taylor M Scott, Daniel R Murphy, Hardeep Singh

Faculty, Staff and Students Publications

IMPORTANCE: Missed test results, defined as test results not followed up within an appropriate time frame, are common and lead to delays in diagnosis and treatment.

OBJECTIVE: To evaluate the effect of a quality improvement collaborative, the Virtual Breakthrough Series (VBTS), on the follow-up rate of 2 types of test results prone to being missed: chest imaging suspicious for lung cancer and laboratory findings suggestive of colorectal cancer.

DESIGN, SETTING, AND PARTICIPANTS: This stepped-wedge cluster-randomized clinical trial was conducted between February 2020 and March 2022 at 12 Department of Veterans Affairs (VA) medical centers, with a predefined 3-cohort roll-out. Each …


Discordance Between Aptt And Anti-Xa In Monitoring Heparin Anticoagulation In Mechanical Circulatory Support, Song Li, Ang Li, Jennifer A Beckman, Christopher Kim, Marian A Granich, John Mondin, Daniel E Sabath, David A Garcia, Claudius Mahr Oct 2024

Discordance Between Aptt And Anti-Xa In Monitoring Heparin Anticoagulation In Mechanical Circulatory Support, Song Li, Ang Li, Jennifer A Beckman, Christopher Kim, Marian A Granich, John Mondin, Daniel E Sabath, David A Garcia, Claudius Mahr

Faculty, Staff and Students Publications

AIMS: It is unclear whether activated partial thromboplastin time (aPTT) or anti-Xa is more accurate for monitoring heparin anticoagulation in mechanical circulatory support (MCS) patients. This study investigates the relationship between aPTT and anti-Xa in MCS patients and identifies predictors of discordance.

METHODS AND RESULTS: aPTT and anti-Xa were simultaneously measured in a prospective cohort of MCS patients receiving unfractionated heparin at a tertiary academic medical centre. Therapeutic aPTT and anti-Xa levels were 60-100 s and 0.3-0.7 IU/mL, respectively, and concordance was defined as both levels being subtherapeutic, therapeutic, or supratherapeutic. To identify predictors of discordance, both a machine learning …


Breakdown Of Boltzmann-Type Models For The Alignment Of Self-Propelled Rods, Patrick Murphy, Misha Perepelitsa, Ilya Timofeyev, Matan Lieber-Kotz, Brandon Islas, Oleg A. Igoshin Oct 2024

Breakdown Of Boltzmann-Type Models For The Alignment Of Self-Propelled Rods, Patrick Murphy, Misha Perepelitsa, Ilya Timofeyev, Matan Lieber-Kotz, Brandon Islas, Oleg A. Igoshin

Faculty Research, Scholarly, and Creative Activity

Studies in the collective motility of organisms use a range of analytical approaches to formulate continuous kinetic models of collective dynamics from rules or equations describing agent interactions. However, the derivation of these kinetic models often relies on Boltzmann's “molecular chaos” hypothesis, which assumes that correlations between individuals are short-lived. While this assumption is often the simplest way to derive tractable models, it is often not valid in practice due to the high levels of cooperation and self-organization present in biological systems. In this work, we illustrated this point by considering a general Boltzmann-type kinetic model for the alignment of …


A Top Model Of Urban Residents’ Subjective Well-Being In China, Bing Pan, Deborah Kerstetter, Xiaoli Yi, Gaojun Zhang, Rui Li, Jie Gao, Xiangyou Sharon Shen, Guangming Li Oct 2024

A Top Model Of Urban Residents’ Subjective Well-Being In China, Bing Pan, Deborah Kerstetter, Xiaoli Yi, Gaojun Zhang, Rui Li, Jie Gao, Xiangyou Sharon Shen, Guangming Li

Faculty Research, Scholarly, and Creative Activity

Past research on subjective well-being (SWB) in Western society and China has revealed various contributing factors. This study conducted a series of interviews with Chinese urban residents to systematically analyze those factors based on Bronfenbrenner’s Ecological System Theory. The results revealed that 5 layers, 23 factors, and 55 elements, many of which had distinct Chinese characteristics, contributed to Chinese urban residents’ SWB. The Top Model of SWB, visualized as a spinning top or gyroscope, showcased the interdependent layers of factors impacting Chinese urban residents’ SWB. At its vertical axis is a time dimension as residents often reflect on factors by …


Dead Fuel Moisture Content Reanalysis Dataset For California (2000–2020), Angel Farguell, Jack Ryan Drucker, Jeffrey Mirocha, Philip Cameron-Smith, Adam Krzysztof Kochanski Oct 2024

Dead Fuel Moisture Content Reanalysis Dataset For California (2000–2020), Angel Farguell, Jack Ryan Drucker, Jeffrey Mirocha, Philip Cameron-Smith, Adam Krzysztof Kochanski

Faculty Research, Scholarly, and Creative Activity

This study presents a novel reanalysis dataset of dead fuel moisture content (DFMC) across California from 2000 to 2020 at a 2 km resolution. Utilizing a data assimilation system that integrates a simplified time-lag fuel moisture model with 10-h fuel moisture observations from remote automated weather stations (RAWS) allowed predictions of 10-h fuel moisture content by our method with a mean absolute error of 0.03 g/g compared to the widely used Nelson model, with a mean absolute error prediction of 0.05 g/g. For context, the values of DFMC in California are commonly between 0.05 g/g and 0.30 g/g. The presented …


Healthy From The Start: Co-Designing Sleep, Nutrition And Physical Activity Resources For Young Shiftworkers—Novel Implementation And Evaluation, Alexandra E. Shriane, Sally A. Ferguson, Gabrielle Rigney, Charlotte C. Gupta, Tracy Kolbe-Alexander, Madeline Sprajcer, Cassie Hilditch, Robert Stanton, Matthew J.W. Thomas, Jessica L. Paterson, Jamie Marino, Grace E. Vincent Oct 2024

Healthy From The Start: Co-Designing Sleep, Nutrition And Physical Activity Resources For Young Shiftworkers—Novel Implementation And Evaluation, Alexandra E. Shriane, Sally A. Ferguson, Gabrielle Rigney, Charlotte C. Gupta, Tracy Kolbe-Alexander, Madeline Sprajcer, Cassie Hilditch, Robert Stanton, Matthew J.W. Thomas, Jessica L. Paterson, Jamie Marino, Grace E. Vincent

Faculty Research, Scholarly, and Creative Activity

Introduction: The increasing prevalence of shiftwork among young adults poses significant health risks, primarily due to its disruptive effects on sleep, nutrition and physical activity. Addressing these risks necessitates the development of tailored, evidence-based resources to support these key health behaviours. Participatory research approaches, engaging those with relevant lived experience (i.e., co-design) are a novel and effective approach in developing these resources. As such, the aim of the present study was to explore whether sleep, nutrition and physical activity resources for young shiftworkers could be developed using participatory, co-design approaches and how co-designers would rate both the approaches used and …


Multivalent Protein-Nucleic Acid Interactions Probed By Composition-Gradient Multiangle Light Scattering, Josephine C Ferreon, Natee Kongchan, Phoebe S Tsoi, Kyoung-Jae Choi, Sophia Kenrick, Joel Neilson, Allan Chris M Ferreon Oct 2024

Multivalent Protein-Nucleic Acid Interactions Probed By Composition-Gradient Multiangle Light Scattering, Josephine C Ferreon, Natee Kongchan, Phoebe S Tsoi, Kyoung-Jae Choi, Sophia Kenrick, Joel Neilson, Allan Chris M Ferreon

Faculty, Staff and Students Publications

Many RNA-binding proteins, such as TDP-43 or CELF1, interact multivalently with nucleic acid repetitive elements. The molecular stoichiometry of protein to nucleic acid is often difficult to assess, particularly by standard electrophoretic mobility shift assays (EMSAs). Here, we investigate the use of composition-gradient multiangle light scattering (CG-MALS) for quantifying binding affinity and stoichiometry for two RNA-binding proteins with their nucleic acid partners of varied sequence and length: TDP43's N-terminal RNA recognition motifs with both TG/GU-repeat ssDNA and ssRNA, respectively, and CELF1's two N-terminal RNA recognition motifs with (TG/UGUU/GU) repeats and an experimentally defined cognate GU-rich element (GRE). Our CG-MALS data …


Mixed Methods Study Protocol: Language Identity, Discrimination, And Mental Health Among Multilingual 1.5 Generation Asian/Asian American Immigrant Young Adults, Chulwoo Park, Mark Edberg, Janet Yougi Bang, Avizia Yim Long Oct 2024

Mixed Methods Study Protocol: Language Identity, Discrimination, And Mental Health Among Multilingual 1.5 Generation Asian/Asian American Immigrant Young Adults, Chulwoo Park, Mark Edberg, Janet Yougi Bang, Avizia Yim Long

Faculty Research, Scholarly, and Creative Activity

Language identity, an understudied factor, can influence isolation and discrimination, leading to disparities in well-being and mental health among immigrants. This study aims to investigate the role of language identity on structural racism and discrimination among 1.5 generation Asian/Asian American immigrants in a diverse U.S. state. We developed a three-step sequential approach: Stage 1—qualitative analysis (1A, focus group discussion; 1B, in-depth interviews); Stage 2—quantitative analysis (2A, language identity measurement scale; 2B, cross-sectional online survey; 2C, multivariate multiple linear regression); Stage 3—another round of qualitative analysis (3A, follow-up in-depth chronological interviews). Therefore, this study will contribute to the field by introducing …


The Sanctuary In Historical Perspective: Exploring The Development Of A Core Adventist Belief, Denis Kaiser Oct 2024

The Sanctuary In Historical Perspective: Exploring The Development Of A Core Adventist Belief, Denis Kaiser

Faculty Publications

No abstract provided.


Associations Of County-Level Social Determinants Of Health With Covid-19 Related Hospitalization Among People With Hiv: A Retrospective Analysis Of The Us National Covid Cohort Collaborative (N3c), Jessica Y. Islam, Eric Hurwitz, Dongmei Li, Marlene Camacho-Rivera, Jing Sun, Sandra Safo, Jennifer M. Ross, Shukri Hassan, Elaine L. Hill, Cara Varley, Multiple Additional Authors Oct 2024

Associations Of County-Level Social Determinants Of Health With Covid-19 Related Hospitalization Among People With Hiv: A Retrospective Analysis Of The Us National Covid Cohort Collaborative (N3c), Jessica Y. Islam, Eric Hurwitz, Dongmei Li, Marlene Camacho-Rivera, Jing Sun, Sandra Safo, Jennifer M. Ross, Shukri Hassan, Elaine L. Hill, Cara Varley, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Individually, the COVID-19 and HIV pandemics have differentially impacted minoritized groups due to the role of social determinants of health (SDoH) in the U.S. Little is known how the collision of these two pandemics may have exacerbated adverse health outcomes. We evaluated county-level SDoH and associations with hospitalization after a COVID-19 diagnosis among people with (PWH) and without HIV (PWOH) by racial/ethnic groups. We used the U.S. National COVID Cohort Collaborative (January 2020-November 2023), a nationally-sampled electronic health record repository, to identify adults who were diagnosed with COVID-19 with HIV (n = 22,491) and without HIV (n = 2,220,660). We …


October 2024 Library & Learning Newsletter, Minnesota State University, Mankato. Library & Learning Dean’S Office Communications Team Oct 2024

October 2024 Library & Learning Newsletter, Minnesota State University, Mankato. Library & Learning Dean’S Office Communications Team

Library & Learning Newsletters

PDF version of the October 2024 (Volume 3, Issue 2) Library & Learning Newsletter.


Cellular Prion Protein Acts As Mediator Of Amyloid Beta Uptake By Caveolin-1 Causing Cellular Dysfunctions In Vitro And In Vivo, Angela Da Silva Correia, Matthias Schmitz, Anna-Lisa Fischer, Susana Da Silva Correia, Franco L Simonetti, Gesine Saher, Roberto Goya-Maldonado, Amandeep Singh Arora, Andre Fischer, Tiago F Outeiro, Inga Zerr Oct 2024

Cellular Prion Protein Acts As Mediator Of Amyloid Beta Uptake By Caveolin-1 Causing Cellular Dysfunctions In Vitro And In Vivo, Angela Da Silva Correia, Matthias Schmitz, Anna-Lisa Fischer, Susana Da Silva Correia, Franco L Simonetti, Gesine Saher, Roberto Goya-Maldonado, Amandeep Singh Arora, Andre Fischer, Tiago F Outeiro, Inga Zerr

Faculty, Staff and Student Publications

Introduction: Cellular prion protein (PrPC) was implicated in amyloid beta (Aβ)-induced toxicity in Alzheimer's disease (AD), but the precise molecular mechanisms involved in this process are unclear.

Methods: Double transgenic mice were generated by crossing Prnp knockout (KO) with 5xFAD mice, and light-sheet microscopy was used for whole brain tissue analyses. PrPC-overexpressing cells were developed for in vitro studies, and microscopy was used to assess co-localization of proteins of interest. Surface-plasmon resonance (SPR) was used to investigate protein-binding characteristics.

Results: In vivo, PrPC levels correlated with reduced lifespan and cognitive and motor function, and its ablation disconnected behavior deficits from …


Outcomes In Solid Organ Transplant Recipients Receiving Organs From A Donor With Fusarium Solani Species Complex Meningitis, Isabel S Griffin, Dallas J Smith, Pallavi Annambhotla, Jeremy A W Gold, Luis Ostrosky-Zeichner, Carol A Kauffman, Lalitha Gade, Anastasia Litvintseva, Daniel Zp Friedman, Angie G Nishio Lucar, Tarina C Parpia, Joshua Lieberman, Janet Bujan, Julie Corkrean, Mukul K Divatia, Kevin Grimes, Jiejian Lin, Constance Mobley, Mary R Schwartz, Bashar Hannawi, Anne Malilay, Anne O'Boye, Jeffrey Lysne, Mrinalini Venkata Subramani, Hayley Heckmann, Venice Servellita, Charles Chiu, Sridhar V Basavaraju Oct 2024

Outcomes In Solid Organ Transplant Recipients Receiving Organs From A Donor With Fusarium Solani Species Complex Meningitis, Isabel S Griffin, Dallas J Smith, Pallavi Annambhotla, Jeremy A W Gold, Luis Ostrosky-Zeichner, Carol A Kauffman, Lalitha Gade, Anastasia Litvintseva, Daniel Zp Friedman, Angie G Nishio Lucar, Tarina C Parpia, Joshua Lieberman, Janet Bujan, Julie Corkrean, Mukul K Divatia, Kevin Grimes, Jiejian Lin, Constance Mobley, Mary R Schwartz, Bashar Hannawi, Anne Malilay, Anne O'Boye, Jeffrey Lysne, Mrinalini Venkata Subramani, Hayley Heckmann, Venice Servellita, Charles Chiu, Sridhar V Basavaraju

Faculty, Staff and Student Publications

Background: Five organs (heart, right lung, liver, right, and left kidneys) from a deceased patient were transplanted into five recipients in four US states; the deceased patient was identified as part of a healthcare-associated fungal meningitis outbreak among patients who underwent epidural anesthesia in Matamoros, Mexico.

Methods: After transplant surgeries occurred, Fusarium solani species complex, a fungal pathogen with a high case-mortality rate, was identified in cerebrospinal fluid from the organ donor by metagenomic next-generation sequencing (mNGS) and fungal-specific polymerase chain reaction and in plasma by mNGS.

Results: Four of five transplant recipients received recommended voriconazole prophylaxis; four were monitored …


Hospital Transfers For Evaluation And Treatment Of Hand Infections: Are All Transfers Necessary?, Samuel G Ruiz, James A Mentz, Dean W Smith Oct 2024

Hospital Transfers For Evaluation And Treatment Of Hand Infections: Are All Transfers Necessary?, Samuel G Ruiz, James A Mentz, Dean W Smith

Faculty, Staff and Student Publications

Background: Hand infections represent a common hand condition in the emergency department and one that frequently requires a hand specialist. The purpose of our study is to analyze hospital transfers for hand infections with a primary outcome being potential clinically avoidable transfers and to identify areas for improvement in the care of hand infections.

Methods: Retrospective review of The Texas Healthcare Information Collection Database from 2015 to 2019. We analyzed all transfers for hand infections. Statistical analyses included: Transfer diagnosis, surgical interventions, length of stay (LOS), the day of the week that the transfer was initiated and whether or not …


Sinclair Lewis Society Newsletter, Vol 33, No. 1, The Sinclair Lewis Society Oct 2024

Sinclair Lewis Society Newsletter, Vol 33, No. 1, The Sinclair Lewis Society

Sinclair Lewis Society Newsletter

"Sinclair Lewis Conference to be Held in Sauk Centre in July 2025"

"Sinclair Lewis and the American Mind," by Greg Davis

"What Were They Reading Then?: Pioneer Realism: A Lantern in Her Hand by Bess Streeter Aldrich" by Ted G. Fleener

"All the Frequent Troubles of Our Days: An American Literature Scholar in Germany During World War II"

"Sinclair Lewis: Chess's Red Master," by Shaun F. Richards

"Breaking into Print"

"What Were They Reading Then?: How to Get to the Top of the Heap: What Makes Sammy Run? by Budd Schulberg" by Sally E. Parry

"Mantrap: The Move"