Digital Commons Network^™

Nigerian Software Engineer Or American Data Scientist? Github Profile Recruitment Bias In Large Language Models, Takashi Nakano, Kazumasa Shimari, Raula Gaikovina Kula, Christoph Treude, Marc Cheong, Kenichi Matsumoto

Research Collection School Of Computing and Information Systems

Large Language Models (LLMs) have taken the world by storm, demonstrating their ability not only to automate tedious tasks, but also to show some degree of proficiency in completing software engineering tasks. A key concern with LLMs is their “black-box” nature, which obscures their internal workings and could lead to societal biases in their outputs. In the software engineering context, in this early results paper, we empirically explore how well LLMs can automate recruitment tasks for a geographically diverse software team. We use OpenAI's ChatGPT to conduct an initial set of experiments using GitHub User Profiles from four regions to …

Registered Replication Report: A Large Multilab Cross-Cultural Conceptual Replication Of Turri Et Al. (2015), Braeden Hall, Kathleen Schmidt, Jordan Wagge, Savannah C. Lewis, Sophia C. Weissgerber, Felix Kiunke, ..., Andree Hartanto

Research Collection School of Social Sciences

According to the justified true belief (JTB) account of knowledge, people can truly know something only if they have a belief that is both justified and true (i.e., knowledge is JTB). This account was challenged by Gettier, who argued that JTB does not explain knowledge attributions in certain situations, later called “Gettier-type cases,” wherein protagonists are justified in believing something to be true, but their belief was correct only because of luck. Laypeople may not attribute knowledge to protagonists with justified but only luckily true beliefs. Although some research has found evidence for these so-called Gettier intuitions, Turri et al. …

Deliberately Making And Correcting Errors In Mathematical Problem-Solving Practice Improves Procedural Transfer To More Complex Problems, Janson Boon Khang Yap, Sarah Shi Hui Wong

Research Collection School of Social Sciences

How can students effectively learn and transfer mathematical procedures to solve new problems? Here, we tested the effects of deliberately committing and correcting errors during mathematical problem-solving practice on transfer of the learned procedures. In two experiments, university students were instructed on mathematical algorithms (synthetic division and matrix multiplication) and solved practice problems during open-book study. Learners were then tested on flexibly adapting the algorithms to solve novel problems that were structurally more complex or embedded in “real-life” scenarios (i.e., mathematical word problems). Deliberately committing and correcting procedural errors during problem-solving practice yielded better transfer than errorless repeated practice (Experiment …

"Asian" Principles For The Recognition And Enforcement Of Foreign Judgments? Singapore As A Case Study, Adeline Chong

Research Collection Yong Pung How School Of Law

This paper considers if there can be said to be an “Asian” body of principles for the recognition and enforcement of foreign judgments. Tapping on the results of a research project which was conducted from 2016 to 2020, it is submitted that the answer to this query is in the negative. However, it is suggested that what marks out the “Asian” approach to private international law is the willingness of Asian countries to look outwards for reform and development and to balance the adoption of international norms against important local norms and objectives. Singapore’s approach to the recognition and enforcement …

Can Federated Learning Solve Ai’S Data Privacy Problem?: A Legal Analysis, Warren B. Chik, Florian Gamper

Research Collection Yong Pung How School Of Law

Federated learning (FL) is a method of training AI systems on different datasets without sharing data. The promise of FL is to enable AI systems to be trained on data, including personal data, while preserving data privacy and confidentiality, and thus, inter alia, facilitate compliance with data protection legislation. FL has generated a considerable interest amongst the computer science community, yet there is a dearth of legal analysis of FL. This is a problem because the question of whether FL facilitates compliance with data protection legislation is a legal question. This article will fill this lacuna by providing a comprehensive …

Maxine Greene And Relational Imagination: Interrelationality As Discourse In Critical Imagination., Seungho Moon

Education: School of Education Faculty Publications and Other Works

Dearest Maxine

Metaphors are your life.

We are strangers as teachers—

we play the Blue Guitar; we

challenge our taken-for-grantedness

and resist “the things as they are”

enthusiastically. I am inspired by you,

my dearest Maxine,

to imagine what might be, what should be.

Don't Page Ortho: A Unified Approach To Post-Operative Pediatric Spinal Fusion Care, Jennifer Glusman, Anne Doran, Mark Kiley, Kevin Baker

Advocate GME

No abstract provided.

Nh 4-H Youth Enrollment Paper Form, Unh Cooperative Extension

UNH Cooperative Extension

No abstract provided.

Sample Lesson Of Maple Tales, Sarah Grosvenor

UNH Cooperative Extension

No abstract provided.

Association Of Aortic Valve Calcium With Dementia And Stroke: The Multi-Ethnic Study Of Atherosclerosis, Natalie Marrero, Kunal Jha, Timothy M Hughes, Alexander C Razavi, Jelani K Grant, Ellen Boakye, Khalil Anchouche, Omar Dzaye, Matthew J Budoff, Jerome I Rotter, Xiuqing Guo, Jie Yao, Alexis C Wood, Roger S Blumenthal, Erin D Michos, George Thanassoulis, Wendy S Post, Michael J Blaha, Chinwe Ibeh, Seamus P Whelton

Faculty, Staff and Students Publications

Background and aims: Calcific aortic valve disease is associated with increased thrombin formation, platelet activation, decreased fibrinolysis, and subclinical brain infarcts. We examined the long-term association of aortic valve calcification (AVC) with newly diagnosed dementia and incident stroke in the Multi-Ethnic Study of Atherosclerosis (MESA).

Methods: AVC was measured using non-contrast cardiac CT at Visit 1. We examined AVC as a continuous (log-transformed) and categorical variable (0, 1-99, 100-299, ≥300). Newly diagnosed dementia was adjudicated using International Classification of Disease codes. Stroke was adjudicated from medical records. We calculated absolute event rates (per 1000 person-years) and multivariable adjusted Cox proportional …

Perceptions Of Non-Using College Students’ Likelihood To Use Nonprescription Or Prescription Stimulants, Judith Frazier

Walden Dissertations and Doctoral Studies

The Substance Abuse and Mental Health Services Administration has highlighted the risk of non-users among college students using illegal prescription stimulants due to misinformation and incorrect assumptions. This qualitative study aimed to explore the perspectives of college students who do not use stimulants on perceived risks, social acceptability, opportunity experiences, and likelihood of using stimulants. The study addressed factors that either encourage or discourage students from using stimulants, as well as the internal and extrinsic incentives associated with this activity, using a phenomenological paradigm. Twelve southern Ohioan students who were not users were interviewed using a structured interviewing technique, which …

Changes In Conjunctival Mononuclear Phagocytes And Suppressive Activity Of Regulatory Macrophages In Desiccation Induced Dry Eye, Jehan Alam, Ebru Yaman, Cintia S De Paiva, De-Quan Li, Gerda Cristal Villalba Silva, Zhen Zuo, Stephen C Pflugfelder

Faculty, Staff and Students Publications

Purpose: To evaluate the effects of dry eye on conjunctival immune cell number and transcriptional profiles with attention to mononuclear phagocytes.

Methods: Expression profiling was performed by single-cell RNA sequencing on sorted conjunctival immune cells from non-stressed and C57BL/6 mice subjected to desiccating stress (DS). Monocle 3 modeled cell trajectory, scATAC-seq assessed chromatin accessibility and IPA identified canonical pathways. Inflammation and goblet cells were measured after depletion of MRC1+ MΦs with mannosylated clodronate liposomes.

Results: Mononuclear phagocytes (monocytes, MΦs, DCs) comprised 72 % of immune cells and showed the greatest changes with DS. Distinct DS induced gene expression patterns were …

Novel Genes Of The Male Reproductive System: Potential Roles In Male Reproduction And As Non-Hormonal Male Contraceptive Targets, Thomas X Garcia, Martin M Matzuk

Faculty, Staff and Students Publications

The development of novel non-hormonal male contraceptives represents a pivotal frontier in reproductive health, driven by the need for safe, effective, and reversible contraceptive methods. This comprehensive review explores the genetic underpinnings of male fertility, emphasizing the crucial roles of specific genes and structural variants (SVs) identified through advanced sequencing technologies such as long-read sequencing (LRS). LRS has revolutionized the detection of structural variants and complex genomic regions, offering unprecedented precision and resolution over traditional next-generation sequencing (NGS). Key genetic targets, including those implicated in spermatogenesis and sperm motility, are highlighted, showcasing their potential as non-hormonal contraceptive targets. The review …

Distinct Landscape And Clinical Implications Of Therapy-Related Clonal Hematopoiesis, Koichi Takahashi, Daisuke Nakada, Margaret Goodell

Faculty, Staff and Student Publications

Therapy-related clonal hematopoiesis (t-CH) is defined as clonal hematopoiesis detected in individuals previously treated with chemotherapy and/or radiation therapy. With the increased use of genetic analysis in oncological care, the detection of t-CH among cancer patients is becoming increasingly common. t-CH arises through the selective bottleneck imposed by chemotherapies and potentially through direct mutagenesis from chemotherapies, resulting in a distinct mutational landscape enriched with mutations in DNA damage-response pathway genes such as TP53, PPM1D, and CHEK2. Emerging evidence sheds light on the mechanisms of t-CH development and potential strategies to mitigate its emergence. Due to its unique characteristics that predominantly …

Racial Equity, Diversity And Inclusion In Bioethics: Recommendations From The Association Of Bioethics Program Directors Presidential Task Force, Sandra Soo-Jin Lee, Alexis Walker, Shawneequa L Callier, Faith E Fletcher, Charlene Galarneau, Nanibaa' Garrison, Jennifer E James, Renee Mcleod-Sordjan, Ubaka Ogbogu, Nneka Sederstrom, Patrick T Smith, Clarence H Braddock, Christine Mitchell

Center for Medical Ethics and Health Policy Staff Publications

Recent calls to address racism in bioethics reflect a sense of urgency to mitigate the lethal effects of a lack of action. While the field was catalyzed largely in response to pivotal events deeply rooted in racism and other structures of oppression embedded in research and health care, it has failed to center racial justice in its scholarship, pedagogy, advocacy, and practice, and neglected to integrate anti-racism as a central consideration. Academic bioethics programs play a key role in determining the field's norms and practices, including methodologies, funding priorities, and professional networks that bear on equity, inclusion, and epistemic justice. …

Update On Recommendations For Surveillance For Children With Predisposition To Hematopoietic Malignancy, Luke D Maese, Marcin W Wlodarski, Sun Young Kim, Alison A Bertuch, Gaelle Bougeard, Vivian Y Chang, Lucy A Godley, Payal P Khincha, Roland P Kuiper, Harry Lesmana, Rose B Mcgee, Lisa J Mcreynolds, Julia Meade, Sharon E Plon, Sharon A Savage, Sarah R Scollon, Hamish S Scott, Michael F Walsh, Kim E Nichols, Christopher C Porter

Center for Medical Ethics and Health Policy Staff Publications

Children harboring certain germline gene variants have an increased risk of developing myelodysplastic syndrome (MDS) and other hematopoietic malignancies (HM), such as leukemias and lymphomas. Recent studies have identified an expanding number of these predisposition genes, with variants most prevalent in children with MDS but also found in children with other HM. For some hematopoietic malignancy predispositions (HMP), specifically those with a high risk of MDS, early intervention through hematopoietic stem cell transplantation can favorably impact overall survival, providing a rationale for rigorous surveillance. A multidisciplinary panel of experts at the 2023 AACR Childhood Cancer Predisposition Workshop reviewed the latest …

“The Truth Should Not Be Hidden”: Experiences And Recommendations Of Individuals Making Npe Discoveries Through Genetic Genealogy Databases, Olivia Schuman, Caroline Beit, Jill Oliver Robinson, Whitney Bash Brooks, Amy L Mcguire, Christi Guerrini

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Fueled by direct-to-consumer (DTC) genetic testing and genetic-relative finder services, some participants in genetic genealogy databases are making "not parent expected" (NPE) discoveries. To better understand experiences of this phenomenon, we surveyed a large cohort of users of genetic relative finder (GRF) services concerning their experiences after an NPE discovery.

Methods: Using thematic analysis, we analyzed responses from a cohort of GRF users (n = 646) to open-ended survey items to understand these experiences and their recommendations for DTC genetic testing companies and other GRF users.

Results: We found that individuals had both positive and negative emotional experiences related …

Cerebellar Deep Brain Stimulation As A Dual-Function Therapeutic For Restoring Movement And Sleep In Dystonic Mice, Luis E Salazar Leon, Linda H Kim, Roy V Sillitoe

Duncan NRI Faculty and Staff Publications

Dystonia arises with cerebellar dysfunction, which plays a key role in the emergence of multiple pathophysiological deficits that range from abnormal movements and postures to disrupted sleep. Current therapeutic interventions typically do not simultaneously address both the motor and non-motor symptoms of dystonia, underscoring the necessity for a multi-functional therapeutic strategy. Deep brain stimulation (DBS) is effectively used to reduce motor symptoms in dystonia, with existing parallel evidence arguing for its potential to correct sleep disturbances. However, the simultaneous efficacy of DBS for improving sleep and motor dysfunction, specifically by targeting the cerebellum, remains underexplored. Here, we test the effect …

Piezo Ion Channels: Force Sensors Of The Interoceptive Nervous System, Yasmeen M F Hamed, Britya Ghosh, Kara L Marshall

Duncan NRI Faculty and Staff Publications

Many organs are designed to move: the heart pumps each second, the gastrointestinal tract squeezes and churns to digest food, and we contract and relax skeletal muscles to move our bodies. Sensory neurons of the peripheral nervous system detect signals from bodily tissues, including the forces generated by these movements, to control physiology. The processing of these internal signals is called interoception, but this is a broad term that includes a wide variety of both chemical and mechanical sensory processes. Mechanical senses are understudied, but rapid progress has been made in the last decade, thanks in part to the discovery …

Tau Is Required For Glial Lipid Droplet Formation And Resistance To Neuronal Oxidative Stress, Lindsey D Goodman, Isha Ralhan, Xin Li, Shenzhao Lu, Matthew J Moulton, Ye-Jin Park, Pinghan Zhao, Oguz Kanca, Ziyaneh S Ghaderpour Taleghani, Julie Jacquemyn, Joshua M Shulman, Kanae Ando, Kai Sun, Maria S Ioannou, Hugo J Bellen

Duncan NRI Faculty and Staff Publications

The accumulation of reactive oxygen species (ROS) is a common feature of tauopathies, defined by Tau accumulations in neurons and glia. High ROS in neurons causes lipid production and the export of toxic peroxidated lipids (LPOs). Glia uptake these LPOs and incorporate them into lipid droplets (LDs) for storage and catabolism. We found that overexpressing Tau in glia disrupts LDs in flies and rat neuron-astrocyte co-cultures, sensitizing the glia to toxic, neuronal LPOs. Using a new fly tau loss-of-function allele and RNA-mediated interference, we found that endogenous Tau is required for glial LD formation and protection against neuronal LPOs. Similarly, …

Human Embryonic Genetic Mosaicism And Its Effects On Development And Disease, Sarah M Waldvogel, Jennifer E Posey, Margaret A Goodell

Center on Aging Staff Publications

Nearly every mammalian cell division is accompanied by a mutational event that becomes fixed in a daughter cell. When carried forward to additional cell progeny, a clone of variant cells can emerge. As a result, mammals are complex mosaics of clones that are genetically distinct from one another. Recent high-throughput sequencing studies have revealed that mosaicism is common, clone sizes often increase with age and specific variants can affect tissue function and disease development. Variants that are acquired during early embryogenesis are shared by multiple cell types and can affect numerous tissues. Within tissues, variant clones compete, which can result …

Dna Vaccines Against Gprc5d Synergize With Pd-1 Blockade To Treat Multiple Myeloma, Praveen Neeli, Perry Ayn Mayson A Maza, Dafei Chai, Dan Zhao, Xen Ping Hoi, Keith Syson Chan, Ken H Young, Yong Li

Faculty, Staff and Students Publications

Multiple myeloma (MM), a hematological malignancy of the bone marrow, remains largely incurable. The orphan G protein-coupled receptor, GPRC5D, which is uniquely expressed in plasma cells and highly expressed in MM, is a compelling candidate for immunotherapy. In this study, we investigated the efficacy of a combination of DNA vaccine encoding mouse GPRC5D and PD-1 blockade in preventing and treating MM using the 5TGM1 murine model of MM. The mouse vaccine alone was effective in preventing myeloma growth but required PD-1 antibodies to inhibit established MM tumors. We next evaluated the prophylactic and therapeutic efficacy of a nanoplasmid vector encoding …

Illinois State Magazine, Fall 2024, University Marketing And Communications

Illinois State Magazine (1999-present)

Alumni magazine for Illinois State University

How Mda Advocacy Saves You Money – And More, Michelle C. Dziurgot Dds

The Journal of the Michigan Dental Association

The editorial emphasizes the value of the Michigan Dental Association’s (MDA) advocacy efforts in improving the dental practice environment and saving dentists money. Key initiatives include a bill ensuring dentists receive full payment without fees, laws regulating network leasing, and the elimination of a state tax on dental prosthetics. The MDA also helped expedite dental office reopenings during COVID-19 and ensured dental professionals were prioritized for vaccinations. Additional efforts include regulating mobile dental operations and updating regulations around sharps container replacement. The editorial encourages support for MDA advocacy through engagement and donations to the MDA Dental PAC.

Dentistry And The Law: Update On The Ftc’S Rule Banning Covenants Not To Compete, Daniel Schulte Jd

The Journal of the Michigan Dental Association

The Federal Trade Commission's (FTC) Final Rule to ban most employee non-compete agreements, originally set to take effect on September 4, 2024, has been delayed due to ongoing litigation. Court decisions in Pennsylvania and Texas have resulted in conflicting rulings regarding the FTC's authority to enforce such a ban. A Pennsylvania district court upheld the FTC's power to regulate non-compete agreements, while a Texas court ruled against it, declaring the ban arbitrary and capricious. No appeals have been filed yet, and the issue remains unresolved, with potential appellate court decisions and the results of the presidential election likely influencing the …

Staff Matters: Things For Practices To Consider During The Election Season, Jodi Schafer Sphr, Shrm-Scp

The Journal of the Michigan Dental Association

The column addresses how a practice owner can support staff who wish to vote in person during a busy workday while maintaining a respectful and productive work environment. Suggestions include offering flexible scheduling or paid time off to allow voting, along with proactive communication to understand staff needs. It also highlights the importance of setting clear boundaries for political discussions in the office to prevent disruptions and maintain a respectful atmosphere. Emphasizing civility, respect, and patient care, the column advises discussing these expectations with staff to avoid conflicts.

Mda Foundation: The Mda Foundation’S Access To Care Grants Are On The Rise, Anne Berquist

The Journal of the Michigan Dental Association

The MDA Foundation has increased its grant awards by 13.5% this year, providing $117,500 to 12 organizations focused on improving access to dental care. Notable recipients include the Gary Burnstein Clinic, awarded a second Diversity and Inclusion grant, and three new organizations: the Shelter Association of Washtenaw, Trinity Community Care, and the Grand Rapids Children’s Museum. Several returning grantees, including Malta Clinic and VINA Clinic, saw increased funding to continue offering free or reduced-cost dental services. Despite slight reductions for a few organizations, the overall grant program expanded, with the Foundation’s total awards increasing by 7.3%. The Foundation continues to …

Outcome Of Vital Pulp Therapy Using Mta And Biodentine In Permanent First Molars With Or Without Pulpitis In Pediatric Patients, Daniel Nho Dmd, Ms, Susan Paurazas Dds, Ms, Mhsa, Mazin Askar Bds, Ms, Salwa Atwan Dds, Ms

The Journal of the Michigan Dental Association

Purpose: This study evaluated the outcome of vital pulp therapy (VPT) in permanent first molar teeth using Biodentine (Septodont, Saint Maur des Fosses, France) or ProRoot MTA (Dentsply Tulsa Dental Specialties, Johnson City, Tenn.) in pediatric patients. Methods: Permanent first molar teeth with or without a history of pulpitis from patients aged 7 to 14 years old were treated at the Graduate Endodontic Clinic from September 2007 to August 2022. A retrospective cohort clinical trial was conducted. VPT was performed on a total of 22 teeth. There were 13 teeth in the Biodentine (BD) group and nine teeth in the …

Dna Methylation-Derived Immune Cell Proportions And Cancer Risk In Black Participants, Christopher S Semancik, Naisi Zhao, Devin C Koestler, Eric Boerwinkle, Jan Bressler, Rachel J Buchsbaum, Karl T Kelsey, Elizabeth A Platz, Dominique S Michaud

Faculty, Staff and Student Publications

Prior cohort studies assessing cancer risk based on immune cell subtype profiles have predominantly focused on White populations. This limitation obscures vital insights into how cancer risk varies across race. Immune cell subtype proportions were estimated using deconvolution based on leukocyte DNA methylation markers from blood samples collected at baseline on participants without cancer in the Atherosclerosis Risk in Communities Study. During a mean of 17.5 years of follow-up, 668 incident cancers were diagnosed in 2,467 Black participants. Cox proportional hazards regression was used to examine immune cell subtype proportions and overall cancer incidence and site-specific incidence (lung, breast, and …

Oligodendroglial Fatty Acid Metabolism As A Central Nervous System Energy Reserve, Ebrahim Asadollahi, Andrea Trevisiol, Aiman S Saab, Zoe J Looser, Payam Dibaj, Reyhane Ebrahimi, Kathrin Kusch, Torben Ruhwedel, Wiebke Möbius, Olaf Jahn, Jun Yup Lee, Anthony S Don, Michelle-Amirah Khalil, Karsten Hiller, Myriam Baes, Bruno Weber, E Dale Abel, Andrea Ballabio, Brian Popko, Celia M Kassmann, Hannelore Ehrenreich, Johannes Hirrlinger, Klaus-Armin Nave

Duncan NRI Faculty and Staff Publications

Brain function requires a constant supply of glucose. However, the brain has no known energy stores, except for glycogen granules in astrocytes. In the present study, we report that continuous oligodendroglial lipid metabolism provides an energy reserve in white matter tracts. In the isolated optic nerve from young adult mice of both sexes, oligodendrocytes survive glucose deprivation better than astrocytes. Under low glucose, both axonal ATP levels and action potentials become dependent on fatty acid β-oxidation. Importantly, ongoing oligodendroglial lipid degradation feeds rapidly into white matter energy metabolism. Although not supporting high-frequency spiking, fatty acid β-oxidation in mitochondria and oligodendroglial …