Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 295681 - 295710 of 5159965

Full-Text Articles in Entire DC Network

Hispanic Heritage Month 2024 Nepantla Performance Flyer, St. Mary's University Communication Department Oct 2024

Hispanic Heritage Month 2024 Nepantla Performance Flyer, St. Mary's University Communication Department

Hispanic Heritage Collection - Current Year (2024)

This is a flyer advertising Ballet Nepantla performance and Q&A session at St. Mary's University as part of Hispanic Heritage Month 2024. Ballet Nepantla, led by Andrea Guajardo and Martín Rodriguez, fuses contemporary dance with Mexican folklorico to explore cultural and historical "in-between-ness," drawing inspiration from Gloria Anzaldúa's borderlands theory.


Hispanic Hertiage Month Schedule Flyer, St. Mary's University Communication Department Oct 2024

Hispanic Hertiage Month Schedule Flyer, St. Mary's University Communication Department

Hispanic Heritage Collection - Current Year (2024)

This poster is an announcement for the Hispanic Heritage Month 2024 events at St. Mary's University, celebrating Hispanic/Latinx culture and identity from September 15th to October 15th, 2024. It lists a variety of events on campus, providing locations, times, and dates for each event.


Assessment And Management Of Vitamin Status In Children With Ckd Stages 2-5, On Dialysis And Post-Transplantation: Clinical Practice Points From The Pediatric Renal Nutrition Taskforce., Caroline E. Anderson, Jetta Tuokkola, Leila Qizalbash, Matthew Harmer, Christina L. Nelms, Stella Stabouli, Barry Toole, Nonnie Polderman, An Desloovere, Jose Renken-Terhaerdt, Molly R Wong Vega, Evelien Snauwaert, Johan Vande Walle, Dieter Haffner, Fabio Paglialonga, Rukshana Shroff, Vanessa Shaw, Larry A. Greenbaum, Bradley A. Warady Oct 2024

Assessment And Management Of Vitamin Status In Children With Ckd Stages 2-5, On Dialysis And Post-Transplantation: Clinical Practice Points From The Pediatric Renal Nutrition Taskforce., Caroline E. Anderson, Jetta Tuokkola, Leila Qizalbash, Matthew Harmer, Christina L. Nelms, Stella Stabouli, Barry Toole, Nonnie Polderman, An Desloovere, Jose Renken-Terhaerdt, Molly R Wong Vega, Evelien Snauwaert, Johan Vande Walle, Dieter Haffner, Fabio Paglialonga, Rukshana Shroff, Vanessa Shaw, Larry A. Greenbaum, Bradley A. Warady

Manuscripts, Articles, Book Chapters and Other Papers

Children with chronic kidney disease (CKD) are at risk for vitamin deficiency or excess. Vitamin status can be affected by diet, supplements, kidney function, medications, and dialysis. Little is known about vitamin requirements in CKD, leading to practice variation.The Pediatric Renal Nutrition Taskforce (PRNT), an international team of pediatric kidney dietitians and pediatric nephrologists, was established to develop evidence-based clinical practice points (CPPs) to address challenges and to serve as a resource for nutritional care. Questions were formulated using PICO (Patient, Intervention, Comparator, Outcomes), and literature searches undertaken to explore clinical practice from assessment to management of vitamin status in …


Influenza C Virus In U.S. Children With Acute Respiratory Infection 2016-2019., Bethany K. Sederdahl, Geoffrey A. Weinberg, Angela P. Campbell, Rangaraj Selvarangan, Jennifer E. Schuster, Joana Y. Lively, Samantha M. Olson, Julie A. Boom, Pedro A. Piedra, Natasha B. Halasa, Laura Stewart, Peter G. Szilagyi, G K Balasubramani, Theresa Sax, Judith M. Martin, Robert W. Hickey, Marian G. Michaels, John V. Williams, New Vaccine Surveillance Network Oct 2024

Influenza C Virus In U.S. Children With Acute Respiratory Infection 2016-2019., Bethany K. Sederdahl, Geoffrey A. Weinberg, Angela P. Campbell, Rangaraj Selvarangan, Jennifer E. Schuster, Joana Y. Lively, Samantha M. Olson, Julie A. Boom, Pedro A. Piedra, Natasha B. Halasa, Laura Stewart, Peter G. Szilagyi, G K Balasubramani, Theresa Sax, Judith M. Martin, Robert W. Hickey, Marian G. Michaels, John V. Williams, New Vaccine Surveillance Network

Manuscripts, Articles, Book Chapters and Other Papers

Influenza C virus (ICV) is an orthomyxovirus related to influenza A and B, yet due to few commercial assays, epidemiologic studies may underestimate incidence of ICV infection and disease. We describe the epidemiology and characteristics of ICV within the New Vaccine Surveillance Network (NVSN), a Centers for Disease Control and Prevention (CDC)-led network that conducts population-based surveillance for pediatric acute respiratory illness (ARI). Nasal or/combined throat swabs were collected from emergency department (ED) or inpatient ARI cases, or healthy controls, between 12/05/2016-10/31/2019 and tested by molecular assays for ICV and other respiratory viruses. Parent surveys and chart review were used …


Participant Engagement And Preference Study For Clinical Outcomes Associated With Atrial Fibrillation: The Pearl-Af Study, Shelby D. Reed, Josephine L. Harrington, Daniel P. Morin, Samir F. Saba, Jay Alan Montgomery, Robert W. Harrison, Daniel R. Frisch, Thomas Viethen, Miriam Tamm, Jessica Xiao, Hardi Mundl, Rosa Coppolecchia, Jui-Chen Yang, Matthew J. Wallace, Juan Marcos Gonzalez, Manesh R. Patel Oct 2024

Participant Engagement And Preference Study For Clinical Outcomes Associated With Atrial Fibrillation: The Pearl-Af Study, Shelby D. Reed, Josephine L. Harrington, Daniel P. Morin, Samir F. Saba, Jay Alan Montgomery, Robert W. Harrison, Daniel R. Frisch, Thomas Viethen, Miriam Tamm, Jessica Xiao, Hardi Mundl, Rosa Coppolecchia, Jui-Chen Yang, Matthew J. Wallace, Juan Marcos Gonzalez, Manesh R. Patel

Division of Cardiology Faculty Papers

Background: Quantifying patients’ preferences for health outcomes associated with atrial fibrillation (AF) and its treatments offers a replicable approach to considering the patient perspective in regulatory decision-making. Objective: The authors conducted a preference survey to estimate the relative importance of AF-related events for use in clinical trial analyses to estimate net health benefits with anticoagulants. Methods: The survey included nontechnical descriptions of three severities of stroke, systemic embolism, myocardial infarction (MI) with or without subsequent heart failure (HF), major bleeding, clinically relevant nonmajor bleeding, and death. A best-worst scaling question format was used in which patients were shown 10 sets …


Hispanic Heritage Month Project-Stmu Oral Histories With Dr. Poyo, Barbara Ortiz Oct 2024

Hispanic Heritage Month Project-Stmu Oral Histories With Dr. Poyo, Barbara Ortiz

Hispanic Heritage Collection - Oral Histories

In this interview, Dr. Poyo discussed his personal and academic trajectory, shaped by his Cuban background and studies across multiple countries and in the United States. He focused on the hurdles encountered by Hispanic students, the significance of strong mentorship, and the evolution of Latino studies at St. Mary's. Dr. Poyo stressed the necessity of weaving Latino history and culture into institutional academics and community engagement. He also mentioned his forthcoming book about Latinos at St. Mary's and the anticipated impact of the Center for Mexican American Studies, underscoring the vital role of ethnic consciousness and cultural pride for young …


El Campanario (Volume 1, Issue 1), St. Mary's University Oct 2024

El Campanario (Volume 1, Issue 1), St. Mary's University

Honors Program Newsletters

No abstract provided.


Clinical Pharmacogenetics Implementation Consortium Guideline (Cpic) For Cyp2d6, Adrb1, Adrb2, Adra2c, Grk4, And Grk5 Genotypes And Beta-Blocker Therapy., Julio D. Duarte, Cameron D. Thomas, Craig R. Lee, Rachel Huddart, Jose A G Agundez, Jordan F. Baye, Andrea Gaedigk, Teri E. Klein, David E. Lanfear, Andrew A. Monte, Mohamed Nagy, Matthias Schwab, C Michael Stein, Chakradhara Rao S. Uppugunduri, Ron H N Van Schaik, Roseann S. Donnelly, Kelly E. Caudle, Jasmine A. Luzum Oct 2024

Clinical Pharmacogenetics Implementation Consortium Guideline (Cpic) For Cyp2d6, Adrb1, Adrb2, Adra2c, Grk4, And Grk5 Genotypes And Beta-Blocker Therapy., Julio D. Duarte, Cameron D. Thomas, Craig R. Lee, Rachel Huddart, Jose A G Agundez, Jordan F. Baye, Andrea Gaedigk, Teri E. Klein, David E. Lanfear, Andrew A. Monte, Mohamed Nagy, Matthias Schwab, C Michael Stein, Chakradhara Rao S. Uppugunduri, Ron H N Van Schaik, Roseann S. Donnelly, Kelly E. Caudle, Jasmine A. Luzum

Manuscripts, Articles, Book Chapters and Other Papers

Beta-blockers are widely used medications for a variety of indications, including heart failure, myocardial infarction, cardiac arrhythmias, and hypertension. Genetic variability in pharmacokinetic (e.g., CYP2D6) and pharmacodynamic (e.g., ADRB1, ADRB2, ADRA2C, GRK4, GRK5) genes have been studied in relation to beta-blocker exposure and response. We searched and summarized the strength of the evidence linking beta-blocker exposure and response with the six genes listed above. The level of evidence was high for associations between CYP2D6 genetic variation and both metoprolol exposure and heart rate response. Evidence indicates that CYP2D6 poor metabolizers experience clinically significant greater exposure and lower heart rate in …


Substance Use Emergency Department Visits Among Youths With Chronic Conditions During Covid-19., Faith Summersett Williams, Isabella Zaniletti, Abbey R. Masonbrink, Robert Garofalo, Maria Rahmandar, Niranjan S. Karnik, Geri Donenberg, Lisa Kuhns Oct 2024

Substance Use Emergency Department Visits Among Youths With Chronic Conditions During Covid-19., Faith Summersett Williams, Isabella Zaniletti, Abbey R. Masonbrink, Robert Garofalo, Maria Rahmandar, Niranjan S. Karnik, Geri Donenberg, Lisa Kuhns

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Pediatric emergency department (ED) visits for substance use (SU) increased during COVID-19. Better understanding of trends associated with SU ED visits among youths with a chronic medical condition (CMC) is needed to target SU screening, prevention, and intervention efforts in this population.

OBJECTIVE: To describe trends in pediatric SU ED visits before and during COVID-19 among youths in the US with and without CMCs and by race and ethnicity.

DESIGN, SETTING, AND PARTICIPANTS: In this cohort study, data were obtained from 47 US children's hospital EDs in the Pediatric Health Information System (PHIS) between March 1, 2018, and March …


The Independence And Empowerment Of International Criminal Tribunals, Peter Koelling Oct 2024

The Independence And Empowerment Of International Criminal Tribunals, Peter Koelling

St. Mary's Journal on Legal Malpractice & Ethics

No abstract provided.


St. Mary's University - Music Department - Adrian Ruiz, Qiuying Chen Oct 2024

St. Mary's University - Music Department - Adrian Ruiz, Qiuying Chen

Music Department

Dr. Ruiz recalls his experiences at the Feista Jazz Festival as performer, director, and other roles. He tells how he prepares for the festival, the challenge of directing it, and much more.


St. Mary's University - Music Department - John Rankin, Qiuying Chen Oct 2024

St. Mary's University - Music Department - John Rankin, Qiuying Chen

Music Department

Dr. John Rankin recollects his journey with the Fiesta Jazz Festival since he joined St. Mary's University Music Department in 1980.


New Opportunities Transfer: Transfer Student Finds Invaluable Resources, Shared Community At St Mary's University, Michelle Mondo Oct 2024

New Opportunities Transfer: Transfer Student Finds Invaluable Resources, Shared Community At St Mary's University, Michelle Mondo

Black History at St. Mary's University - 2025 Collection

Transferring to a new University can pose many questions, such as how someone will fit into their new community, or if it will help them in their overall goals, for A’marie Pollard, St. Mary’s University was able to answer those questions and then some. After transferring to St. Mary’s University as a junior, Pollard was able to take part in the Eugene Scassa Mock Organization of American States Summit, an opportunity not available at her previous university. In addition to that, Pollard commends the St. Mary’s Staff for their support during a time of hardship. St. Mary’s focus on community …


Blurring Boundaries: A Proposed Research Agenda For Ethical, Legal, Social, And Historical Studies At The Intersection Of Infectious And Genetic Disease, Seethal Jose, Juli Bollinger, Gail Geller, Jeremy Greene, Leslie Meltzer Henry, Brian Hutler, Eric Thomas Juengst, Jeffrey Kahn, Anna Mastroianni, Graham Mooney Oct 2024

Blurring Boundaries: A Proposed Research Agenda For Ethical, Legal, Social, And Historical Studies At The Intersection Of Infectious And Genetic Disease, Seethal Jose, Juli Bollinger, Gail Geller, Jeremy Greene, Leslie Meltzer Henry, Brian Hutler, Eric Thomas Juengst, Jeffrey Kahn, Anna Mastroianni, Graham Mooney

Articles

Contemporary understanding of the mechanisms of disease increasingly points to examples of “genetic diseases” with an infectious component and of “infectious diseases” with a genetic component. Such blurred boundaries generate ethical, legal, and social issues and highlight historical contexts that must be examined when incorporating host genomic information into the prevention, outbreak control, and treatment of infectious diseases.


The Anchor: October 2024, Issue One, Hope College Oct 2024

The Anchor: October 2024, Issue One, Hope College

The Anchor: 2024

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.


Strategies For Prevention And Management Of Non-Communicable Diseases Among Community Women In Nigeria: Insights For Family Social Welfare, Abiola Adiat Omokhabi Dr Oct 2024

Strategies For Prevention And Management Of Non-Communicable Diseases Among Community Women In Nigeria: Insights For Family Social Welfare, Abiola Adiat Omokhabi Dr

Journal of Human Services: Training, Research, and Practice

In this study, modifiable risk factors, prevention and management plans for non-communicable diseases (NCDs) among women were examined. This study examined published and grey literature that was gathered from a number of sources, such as open data portals on the five major illness categories that make up the NCDs such as cardiovascular diseases (CVDs), diabetes, malignancies, chronic respiratory diseases, and mental health. Literature shows that the primary behavioural risk factors for NCDs, including CVDs, diabetes, and cancer(malignancies), can be largely avoided. Inactivity, tobacco use, alcohol use, and unhealthy eating habits (often high in processed sugar, fats, and salt) are a …


Voices From The Classroom: A Qualitative Study Of Teachers' Perspectives On Student Depression, Naomi Brinton, Jacqlyn Zarabba, Linda Mcwhorter, Linda Knauss Oct 2024

Voices From The Classroom: A Qualitative Study Of Teachers' Perspectives On Student Depression, Naomi Brinton, Jacqlyn Zarabba, Linda Mcwhorter, Linda Knauss

Journal of Human Services: Training, Research, and Practice

Rising levels of depression among adolescents is an important issue to teachers and school administrators, as teenagers spend the majority of their time in the school environment. By analyzing individual interviews with 15 public high school teachers using a modified grounded theory approach, this qualitative study examines the role high school teachers might play in identifying and referring students who exhibit signs and symptoms of depression. Results provide guidance for high school teachers in connecting students with appropriate services and identifying common barriers and facilitating factors in this process. Specific recommendations are outlined to help aid schools in the identification …


Meeting The Challenge Of Covid-19: Innovation And Adaptation In Services For Expectant And Parenting Youth In Baltimore, Margo Candelaria, Corey Shdaimah, Jenny Afkinich, Yan (Stella) Zhu Oct 2024

Meeting The Challenge Of Covid-19: Innovation And Adaptation In Services For Expectant And Parenting Youth In Baltimore, Margo Candelaria, Corey Shdaimah, Jenny Afkinich, Yan (Stella) Zhu

Journal of Human Services: Training, Research, and Practice

To explore perspectives on COVID-19’s impact on access to services for expectant and parenting youth (EPY), qualitative interviews were conducted with seven service providers and two parents. Open coding resulted in three overarching themes. 1. Creativity and adaptation: pride regarding ability to devise necessary modifications. 2. New and ongoing networks: inter-agency collaboration, provider-parent relationships, and parent networks offered material and social support. 3. Communication: varied strategies helped maintain and initiate EPY engagement. In under-resourced environments where providers and EPY must be creative due to scarcity, COVID-19 required that respondents draw on existing networks and strategies to cope with new challenges.


The Role Of Effective Interprofessional Collaboration In Social Worker Burnout In A Northeastern Veterans Affairs Medical Center: Implications For Social Work Education, Michael L. Clarkson-Hendrix Oct 2024

The Role Of Effective Interprofessional Collaboration In Social Worker Burnout In A Northeastern Veterans Affairs Medical Center: Implications For Social Work Education, Michael L. Clarkson-Hendrix

Journal of Human Services: Training, Research, and Practice

This preliminary study explored effective interprofessional collaboration’s role on social worker burnout within a single Veterans Affairs medical center. Twenty-one social workers completed a survey to collect data on burnout, effective interprofessional collaboration components, and demographic characteristics. On average, social workers reported moderately low burnout levels. As collective ownership of goals increased, burnout decreased. Similarly, as reflection on interprofessional team processes increased, burnout decreased. Future research would benefit from a large, randomly-sampled group of social work participants across multiple sectors to develop implications for social work education. Including measures of person, client, and work characteristics that have been previously associated …


Training Counselors In Clinical Case Formulation: A Proof Of Concept Of The Thematic Mapping Method, Christina E. Jeffrey, Charles Ridley, Nina Quintana, Taylor Parks Oct 2024

Training Counselors In Clinical Case Formulation: A Proof Of Concept Of The Thematic Mapping Method, Christina E. Jeffrey, Charles Ridley, Nina Quintana, Taylor Parks

Journal of Human Services: Training, Research, and Practice

Case formulation, or the way in which clinicians synthesize client information and formulate appropriate treatment directions, is a crucial part of counseling and clinical training. Thematic mapping is a transtheoretical, transdiagnostic strategy of case conceptualization that provides a holistic, complex, multicultural formulation of clients. This proof of concept study evaluated the relationship of a training in the thematic mapping method and case conceptualization quality. Supervisors trained six second-year counselors in the method, along with application to clinical cases, during weekly group supervision. Case formulation complexity, evidence of a systematic approach, level of detail, and goodness-of-fit from client data to synthesized …


Law Library Blog (October 2024): Legal Beagle's Blog Archive, Roger Williams University School Of Law Oct 2024

Law Library Blog (October 2024): Legal Beagle's Blog Archive, Roger Williams University School Of Law

Law Library Newsletters/Blog

No abstract provided.


Sex Differences In Active Avoidance And Neural Circuit Mechanisms In Contextual Fear Generalization, Carly Vincent Oct 2024

Sex Differences In Active Avoidance And Neural Circuit Mechanisms In Contextual Fear Generalization, Carly Vincent

Theses and Dissertations

The current studies were aimed to investigate two behavioral hallmarks of anxiety and stress-related disorders, avoidance responses and the over-generalization of fear. In the first set of studies, active avoidance and extinction learning, that parallels exposure therapy in preclinical rodent models, were used. It is known that stress can influence aversive learning and extinction training, which can result in poor extinction retention. However, it is not well understood how the stress response is facilitating extinction resistance in active avoidance learning across sexes. Therefore, the first set of studies aimed to investigate the role of biological sex and glucocorticoid receptor (GR) …


Design And Application Of Redox-Mediated Flow Electrode Electrodialysis For Ion Removal And Recovery, Rongxuan Xie Oct 2024

Design And Application Of Redox-Mediated Flow Electrode Electrodialysis For Ion Removal And Recovery, Rongxuan Xie

Theses and Dissertations

To meet the growing demand for freshwater driven by population growth and rising living standards, the first desalination plants were established in the late 1950s. As energy costs have risen over time, research has increasingly focused on reducing the overall cost of water treatment. Electrodialysis (ED), which facilitates the migration of anions and cations across ion exchange membranes under the influence of an electric field, has gained significant attention as a treatment method for saline water and brine due to its simplicity, low cost, and scalability. However, its traditional batch operation mode and the potential for generating flammable gases have …


Autonomous Real-Time Model Updating Within Digital Twin Frameworks For Thermal Systems, Braden Robert Priddy Oct 2024

Autonomous Real-Time Model Updating Within Digital Twin Frameworks For Thermal Systems, Braden Robert Priddy

Theses and Dissertations

As engineering systems increase in scale and complexity in the era of the Fourth Industrial Revolution, data-driven solutions will become essential in enabling the next generation of these systems. One of the trending tools that can aid in this transition is digital twins. As physical systems degrade throughout their life cycles, their behavior also changes. Digital twins use data assimilation to continuously update virtual models to represent the current state of their physical counterparts. A reliable digital twin can be leveraged by a system operator to perform diagnostics, optimize, and tests without ever needing the physical system. However, implementing effective …


Advancement Of The Zinc Ion Battery: Polymer Electrolyte And Electrode Development For Aqueous Zinc-Ion Batteries, Roya Rajabi Oct 2024

Advancement Of The Zinc Ion Battery: Polymer Electrolyte And Electrode Development For Aqueous Zinc-Ion Batteries, Roya Rajabi

Theses and Dissertations

Rechargeable aqueous zinc-ion batteries (ZIBs) have garnered significant attention in recent years as a promising candidate for stationary large-scale energy storage due to their distinct safety features and cost-effectiveness compared to conventional lithium-ion batteries. Despite their great potential, ZIBs are currently facing critical challenges for commercialization, including poor cycle stability at low discharge rates, lower energy density (Wh/kg) and higher self-discharge rate. These issues must be addressed for them to become a viable energy storage solution. The above challenges are fundamentally rooted in the bulk properties of electrolytes and interactions with electrodes, such as; 1) formation of insulating layered double …


Augmented Reality (Ar) And Virtual Reality (Vr)-Based Data Visualization Frameworks For The Manufacturing Industry, Nitol Saha Oct 2024

Augmented Reality (Ar) And Virtual Reality (Vr)-Based Data Visualization Frameworks For The Manufacturing Industry, Nitol Saha

Theses and Dissertations

Industry 4.0 is transforming the manufacturing industry by integrating digital technologies throughout the production lifecycle, leading to the development of smart factories. The integration of Augmented Reality (AR) and Virtual Reality (VR) alongside smart manufacturing is transforming traditional industry practices by establishing a robust cyber-physical infrastructure, enhanced data visualization, and improved task execution. This thesis aims to develop AR and VR-based data visualization frameworks for the manufacturing industry, focusing on detailed implementation strategies, initial results, and key findings of these frameworks. One major focus of these frameworks is the generalization of the technological assets so that these frameworks can be …


Comparing Likert And Slider Response Formats In Clinical Assessment, Guyin Zhang Oct 2024

Comparing Likert And Slider Response Formats In Clinical Assessment, Guyin Zhang

Theses and Dissertations

This study used a within-subjects experimental design to compare various response formats in fitting confirmatory factor analysis (CFA) models. Participants responded to the 8-item Center for Epidemiologic Studies Depression Scale (CES-D) across four different response formats: the Likert-type scale, three types of slider response formats, and a number-entry response format. We conducted the comparison of different response formats based on item-level scores, factor structure and psychometric properties of the scale, mean comparisons across groups, and individuals’ sum scores. Similar results were observed across the different response formats with respect to factor structure, reliability, and validity of test scores. However, inconsistent …


Electroless Deposition And Galvanic Displacement For The Control Of Supported Nanoparticle Size And Composition, Haiying Zhou Oct 2024

Electroless Deposition And Galvanic Displacement For The Control Of Supported Nanoparticle Size And Composition, Haiying Zhou

Theses and Dissertations

Catalyst performances can be greatly affected by properties such as particle size, composition, geometry, and cleanliness of the active surface. To achieve optimal catalytic performance, appropriate synthesis methods are required to synthesize the desired structures. Supported metal particle catalysts are usually prepared by impregnation and precipitation methods in industry. Although these two methods are simple, they exhibit poor control over surface morphology, leading to a wide particle size distribution and uncontrolled distribution of different metal components. In this dissertation, three topics on controlling surface morphology are discussed.

For structure sensitive reactions, reactivity and selectivity can be strongly affected by particle …


Discovering Therapeutic Strategies In Colorectal Cancer Via Synthetic Lethal Genetic Screens On Patient-Derived Organoid Models, Sana Khalili Oct 2024

Discovering Therapeutic Strategies In Colorectal Cancer Via Synthetic Lethal Genetic Screens On Patient-Derived Organoid Models, Sana Khalili

Theses and Dissertations

Precision medicine is a revolutionary approach of targeting genetic alterations that are present only in tumor cells to find vulnerabilities that can be targeted with therapy. Identifying genetic dependencies in human colon cancer could help identify effective treatment strategies. Genome-wide CRISPR-Cas9 dropout screens can reveal all genetic dependencies, some of which could be exploited as therapeutic targets using existing drugs.

In this dissertation, I comprehensively characterized genetic dependencies present in a colon cancer organoid avatar, and validated tumor-specific selectivity of select pharmacologic agents. I identified all somatic mutations, all expressed genes, and conducted a genome-wide CRISPR dropout screen to elucidate …


Impacts Of Ing4-Deficiency On Hematopoietic Stem And Progenitor Cells & Characterizing The Concerns Of Novice Stem Graduate Teaching Assistant, Georgina Alice Anderson Oct 2024

Impacts Of Ing4-Deficiency On Hematopoietic Stem And Progenitor Cells & Characterizing The Concerns Of Novice Stem Graduate Teaching Assistant, Georgina Alice Anderson

Theses and Dissertations

The hematopoietic compartment is tasked with the establishment and maintenance of the entire blood program in steady-state and in response to stress. Key to this process are hematopoietic stem cells (HSCs), which possess the unique ability to self-renew and differentiate to replenish blood cells throughout an organism’s lifetime. Recent work has illustrated the vast mechanisms involved in regulating stress-induced hematopoiesis, including cytokine-mediated lineage bias, gene signature changes in aged HSCs associated with chronic inflammation, the impact of clonal hematopoiesis and stress tolerance. Inhibitor of Growth 4 (Ing4) has been identified as a critical regulator of HSC homeostasis. We show that …