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Are Sleeves Necessary In Static Computer-Assisted Implant Surgery? A Comparative In Vitro Analysis, Jenna Hang, Arndt Guentsch Oct 2024

Are Sleeves Necessary In Static Computer-Assisted Implant Surgery? A Comparative In Vitro Analysis, Jenna Hang, Arndt Guentsch

School of Dentistry Faculty Research and Publications

Objectives

This study aims to examine differences in trueness and precision between surgical guides with (S) and without sleeves (SL). A secondary aim was to assess the impact of the sleeve-to-bone distance.

Materials and Methods

Mandible replicas (n = 120) were printed from an STL file obtained from a clinical CBCT. The mandibles were divided into sleeved (S, n = 60) and sleeveless (SL, n = 60) groups, each further divided into three categories (n = 20 each) with different heights from the guide to the implant platform: 2 mm (H2), 4 mm (H4), or 6 mm (H6). …


Overview Of The Advancing Military-Connected Entrepreneurship Summit, Rosalinda V. Maury, Adam Pritchard Oct 2024

Overview Of The Advancing Military-Connected Entrepreneurship Summit, Rosalinda V. Maury, Adam Pritchard

Institute for Veterans and Military Families

This infographic highlights key findings from The Military-Connected Entrepreneurship Ecosystem: Growth, Empowerment & Connectivity Summit, funded by Walmart. The summit addressed key challenges faced by military-connected entrepreneurs, including access to corporate procurement, ecosystem integration, capability development, and corporate engagement strategies. Held at the Veteran EDGE Conference in Dallas, TX, the summit brought together 13 corporate and business ecosystem partners and 51 military-connected business owners to discuss opportunities and challenges in the private sector.


Military-Connected Entrepreneurship Ecosystem: Advancing Military-Connected Entrepreneurship, Rosalinda V. Maury, Adam Pritchard Oct 2024

Military-Connected Entrepreneurship Ecosystem: Advancing Military-Connected Entrepreneurship, Rosalinda V. Maury, Adam Pritchard

Institute for Veterans and Military Families

This report provides detailed findings from the Military-Connected Entrepreneurship Ecosystem: Growth, Empowerment & Connectivity Summit, funded by Walmart, that brought together military-connected business owners and corporate partners to discuss ways to support military-connected businesses seeking corporate procurement opportunities. The goal of this summit and report is to foster collaboration and improve opportunities for military-connected entrepreneurs.


Tender Rejection Under Article 393 Of The Polish Public Procurement Law (Ppl) – Remarks De Lege Lata And De Lege Ferenda, Joanna Affre, Mateusz Restel Oct 2024

Tender Rejection Under Article 393 Of The Polish Public Procurement Law (Ppl) – Remarks De Lege Lata And De Lege Ferenda, Joanna Affre, Mateusz Restel

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The article examines how Poland has implemented Article 85 of Directive 2014/25/EU, and determines what consequences arise from the discrepancies between the wording of Polish and EU provision. The prerequisites that allow contracting authorities to exercise the right to reject a tender, due to the origin of the products covered by it, are identifi ed, and an interpretation of each of these prerequisites is provided. This discussion responds to problems related to the application of Article 393(1) point 4 of the Polish Public Procurement Law (PPL). The paper calls for the amendment of this provision, by introducing an obligation to …


Justification For The Introduction Of The Eu Short-Term Rentals (Str) Regulation In The Context Of The Housing Market In The Eu, Paweł Budny Oct 2024

Justification For The Introduction Of The Eu Short-Term Rentals (Str) Regulation In The Context Of The Housing Market In The Eu, Paweł Budny

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Given the priority status of ensuring universal access to decent and affordable housing at the EU level, the EU legislator has highlighted the need for harmonization in the collection of data on short-term rentals of residential units through sharing economy platforms. The dynamic growth of platform tourism, observed across the EU in recent years, justifies the need for the introduction of EU Regulation 2024/1028 on Short-Term Rentals (STR), which imposes on collaborative economy platforms that operate on the short-term property rental market, the obligation to provide relevant authorities with data on landlords and units associated with the services provided. The …


Selected Aspects Of The Organization Of Tourism And Recreation In Natural Areas With Different Status Of Legal Protection, Marcin Pasek, Dominik Borek Oct 2024

Selected Aspects Of The Organization Of Tourism And Recreation In Natural Areas With Different Status Of Legal Protection, Marcin Pasek, Dominik Borek

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

An important place in the strategy of promoting health of modern societies, especially in the post-pandemic world, is played by orienting recommendations on how to spend free time towards tourism and recreation in the natural environment. The utilitarian nature of this type of activity is associated with the need to respect legal provisions, relating to the use of statutory forms of nature conservation, as well as non-statutory protection areas. The aim of the study is to characterize the tourist-recreational use in both of the abovementioned types of ecological habitats, and to indicate the similarities and differences in the conditions of …


Report On The Series Of Seminars On The Mutual Infl Uence Of Competition Law And Labour Law In The Era Of ‘Platformization’, July 2022 – September 2023, Warsaw/Rzeszów – Porto, Agata Jurkowska-Gomułka, Sylwia K. Mazur Oct 2024

Report On The Series Of Seminars On The Mutual Infl Uence Of Competition Law And Labour Law In The Era Of ‘Platformization’, July 2022 – September 2023, Warsaw/Rzeszów – Porto, Agata Jurkowska-Gomułka, Sylwia K. Mazur

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Seminar report


Leads Data Insights: Equity — October 2024, University Of North Dakota Oct 2024

Leads Data Insights: Equity — October 2024, University Of North Dakota

LEADS Implementation Documents

October 2024 Data Insights presentation for the EQUITY core value of UND LEADS. The slides review Equity-related Activity Inventory coverage and summarize data on differential student retention and degree-completion outcomes, textbook and course-resource costs, and student subpopulation trends.


Innovation Challenges In The Air Force Sbir Program: From The Small Businesses' Perspective, Hart J. Holt, Amy M. Cox, Scott Drylie, David S. Long, Alfred E. Thal Jr., Robert D. Fass Oct 2024

Innovation Challenges In The Air Force Sbir Program: From The Small Businesses' Perspective, Hart J. Holt, Amy M. Cox, Scott Drylie, David S. Long, Alfred E. Thal Jr., Robert D. Fass

Faculty Publications

Every year the United States invests $3.2 billion in the Small Business Innovation Research (SBIR) program to promote innovation among the nation’s small businesses. Half of this investment is from the DoD. This research considers the challenges faced by small businesses innovating with the DoD, particularly those awarded SBIR contracts with the United States Air Force. The authors surveyed 286 unique small businesses that were previously awarded an Air Force SBIR contract. By asking the survey respondents open-ended questions and categorizing their responses, they pinpoint unaddressed challenges from the small business perspective. By categorizing survey responses through Qualitative Content Analysis, …


The Importance Of Probes In Assessing Periodontal Health, Khrystyna Vyprynyuk, Catherine Monchik Oct 2024

The Importance Of Probes In Assessing Periodontal Health, Khrystyna Vyprynyuk, Catherine Monchik

Publications and Research

No abstract provided.


On Application Of A Surrogate Model To Numerical Evaluation Of Effective Elastic Properties Of Composites With 3d Rotationally Symmetric Particles, Pascal Alexander Happ, Igor Tsukrov, Romana Piat Oct 2024

On Application Of A Surrogate Model To Numerical Evaluation Of Effective Elastic Properties Of Composites With 3d Rotationally Symmetric Particles, Pascal Alexander Happ, Igor Tsukrov, Romana Piat

Faculty Publications

Micromechanical modelling of particulate composites with non-ellipsoidal particle shapes presents significant challenges because analytical approaches based on the fundamental results of Eshelby cannot be used. On the other side, direct numerical evaluations by finite element analysis can involve high computational cost in the case when particle features have small radius of curvature, sharp edges and require extremely fine meshes. This paper proposes substituting the exact particle shape with a surrogate model producing approximately the same contribution to the effective elastic moduli. We illustrate our approach by considering rotationally symmetric 3D particle shapes with the external surface defined by the Laplace's …


A Coupled Spatial-Network Model: A Mathematical Framework For Applications In Epidemiology, Hannah Kravitz, Christina Duron, Moysey Brio Oct 2024

A Coupled Spatial-Network Model: A Mathematical Framework For Applications In Epidemiology, Hannah Kravitz, Christina Duron, Moysey Brio

Mathematics and Statistics Faculty Publications and Presentations

There is extensive evidence that network structure (e.g., air transport, rivers, or roads) may significantly enhance the spread of epidemics into the surrounding geographical area. A new compartmental modeling framework is proposed which couples well-mixed (ODE in time) population centers at the vertices, 1D travel routes on the graph’s edges, and a 2D continuum containing the rest of the population to simulate how an infection spreads through a population. The edge equations are coupled to the vertex ODEs through junction conditions, while the domain equations are coupled to the edges through boundary conditions. A numerical method based on spatial finite …


On Localization Of Eigenfunctions Of The Magnetic Laplacian, Jeffrey S. Ovall, Hadrian Quan, Robyn Reid, Stefan Steinerberger Oct 2024

On Localization Of Eigenfunctions Of The Magnetic Laplacian, Jeffrey S. Ovall, Hadrian Quan, Robyn Reid, Stefan Steinerberger

Mathematics and Statistics Faculty Publications and Presentations

Let Ω ⊂ ℝd and consider the magnetic Laplace operator given by H(A) = (–i∇ – A(x))2, where A : Ω → ℝd, subject to Dirichlet boundary conditions. For certain vector fields A, this operator can have eigenfunctions, H(A)ψ = λψ, that are highly localized in a small region of Ω. The main goal of this paper is to show that if |ψ| assumes its maximum at x0 ∈ Ω, then A behaves 'almost' like a conservative vector field in a -neighborhood of x0 in a precise sense. In particular, we expect localization in regions where |curl A| is small. …


Conducting Structure-From-Motion (Sfm) Modeling Of Freshwater Environments Using Unpiloted Aerial Systems (Uas): Challenges And Lessons Learned, Benjamin T. Fraser, Christine L. Bunyon, Russell G. Congalton Oct 2024

Conducting Structure-From-Motion (Sfm) Modeling Of Freshwater Environments Using Unpiloted Aerial Systems (Uas): Challenges And Lessons Learned, Benjamin T. Fraser, Christine L. Bunyon, Russell G. Congalton

Faculty Publications

The pairing of Unpiloted Aerial Systems (UAS) and Structure from Motion (SfM) has provided new capabilities for modeling freshwater environments. Applications of UAS-SfM range from water quality monitoring to the mapping of aquatic vegetation. The models produced provide users with the ability to analyze features at ultra-high-resolutions and across scales not easily achieved through in situ sampling. Despite the demonstrated benefits of UAS-SfM in freshwater and other natural resource disciplines, there remain fundamental technical challenges in the modeling of environments with homogenous surfaces (e.g., water). In this research, the effectiveness of several image collection and processing approaches for the modelling …


High-Latitude Observations Of Dissipation-Range Turbulence By The Ulysses Spacecraft During The Solar Minimum Of 1993–96: The Spectral Break And Anisotropy, Abigale S. Watson, Charles W. Smith, Anastasia V. Marchuk, Matthew R. Argall, Colin J. Joyce, Philip A. Isenberg, Bernard J. Vasquez, Nathan A. Schwadron, Neil Murphy Oct 2024

High-Latitude Observations Of Dissipation-Range Turbulence By The Ulysses Spacecraft During The Solar Minimum Of 1993–96: The Spectral Break And Anisotropy, Abigale S. Watson, Charles W. Smith, Anastasia V. Marchuk, Matthew R. Argall, Colin J. Joyce, Philip A. Isenberg, Bernard J. Vasquez, Nathan A. Schwadron, Neil Murphy

Faculty Publications

We examine Ulysses magnetic field observations from 1993 to 1996 as the spacecraft made its first fast-latitude scan from the southern to the northern hemisphere. Most of the observations we use are representative of high-latitude solar minimum conditions. We examine magnetic field power spectra characteristics of interplanetary turbulence at high frequencies, where the spectrum breaks from an inertial range into the ion dissipation range. The onset and spectral index of the dissipation spectrum are consistent with low-latitude observations at 1 au. Both ranges have a ratio of power in perpendicular magnetic field components to parallel components near 3. The power …


Minimal Wordlist Size For A Phonological Profile: New Evidence From Kra-Dai Languages, Kanyarin Boonkongchuen , '25 Oct 2024

Minimal Wordlist Size For A Phonological Profile: New Evidence From Kra-Dai Languages, Kanyarin Boonkongchuen , '25

Senior Theses, Projects, and Awards

This study replicates, and extends to Kra-Dai languages, earlier work on minimal wordlist size needed to make a phonological profile of a language. Previous work on Australian languages recommended approximately 400 randomly sampled words to comprise a minimally complete profile in terms of reliably capturing every phoneme, and with accurate distribution. We survey 55 Kra-Dai languages to show that a longer minimal list is necessary, which we attribute to typological differences like larger consonant/vowel inventories. Given the widespread use of short wordlists in fieldwork, these results hold significance for designing language documentation surveys as well as projects that use legacy …


A Step Into Khmer’S Double Negation Mystery: Clause-Final Marker ទេ[Te:] As Negative Polarity Focus, Panhavoan Reth , '25 Oct 2024

A Step Into Khmer’S Double Negation Mystery: Clause-Final Marker ទេ[Te:] As Negative Polarity Focus, Panhavoan Reth , '25

Senior Theses, Projects, and Awards

In Khmer, basic negation is formed using two negation elements: the preverbal marker មិន [mɨn] and the clause-final marker ទេ[te:]. However, there are cases where [te:] is optional with the utterance still retaining its negative meaning; when it is present, it is claimed that the utterance can have two readings: plain negation and emphatic negation (Saparova, 2020). Thus, there is speculation as to what function [te:] serves and what it contributes to the semantic meaning of a sentence. This thesis examines the optionality of [te:] through the lens of polarity focus, drawing on Wilder’s (2013) and Goodhue’s (2018, 2022) observations. …


Clomazone And Oxyfluorfen Combinations In A Flooded Rice System, Jason K. Norsworthy, Casey H. Arnold, Thomas R. Butts, Trenton L. Roberts, Chad W. Shelton Oct 2024

Clomazone And Oxyfluorfen Combinations In A Flooded Rice System, Jason K. Norsworthy, Casey H. Arnold, Thomas R. Butts, Trenton L. Roberts, Chad W. Shelton

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Rice producers battle herbicide-resistant weeds worldwide while producing rice for ≥50% of the world’s population. Oxyfluorfen can provide rice producers with an alternative site of action for barnyardgrass control, as there are no documented cases of grass weeds being resistant to the herbicide in the mid-southern United States. Oxyfluorfen is anticipated to be labeled in the Roxy Rice Production System and may be sold as a clomazone/oxyfluorfen premixture; hence, experiments were conducted in 2021 and 2022 to evaluate preemergence-applied clomazone/oxyfluorfen ratios compared to clomazone alone on silt loam and clay soils. All ratios of the herbicides caused less than 7% …


Associations Between Self-Reported Levels Of Aggression, Irritability, And Depression In Collegiate Athletes With A History Of Concussion, Amber Mae Bankston Oct 2024

Associations Between Self-Reported Levels Of Aggression, Irritability, And Depression In Collegiate Athletes With A History Of Concussion, Amber Mae Bankston

Theses and Dissertations

Objective: The aim of this study was to examine the relationship between history of concussion and symptoms of aggression, irritability, and depression. Furthermore, the relationship between these variables were examined in a small subgroup of participants before and after sustaining a head injury.

Methods: Archival data of NCAA Division II and club collegiate athletes from Florida Institute of Technology was included in the present study. Participants were included in this study if they completed baseline and/or post-trauma neuropsychological evaluations that included the Patient Health Questionnaire-9 (PHQ-9), Buss Perry Aggression Questionnaire (BPAQ), and Irritability Questionnaire (IRQ). Athletes’ demographic information along with …


Continuous Kidney Replacement Therapy And Survival In Children And Young Adults: Findings From The Multinational We-Rock Collaborative, Michelle C Starr, Katja M Gist, Huaiyu Zang, Nicholas J Ollberding, Shanthi Balani, Andrea Cappoli, Eileen Ciccia, Catherine Joseph, Aadil Kakajiwala, Aaron Kessel, Melissa Muff-Luett, María J Santiago Lozano, Matthew Pinto, Stephanie Reynaud, Sonia Solomon, Cara Slagle, Rachana Srivastava, Weiwen V Shih, Tennille Webb, Shina Menon Oct 2024

Continuous Kidney Replacement Therapy And Survival In Children And Young Adults: Findings From The Multinational We-Rock Collaborative, Michelle C Starr, Katja M Gist, Huaiyu Zang, Nicholas J Ollberding, Shanthi Balani, Andrea Cappoli, Eileen Ciccia, Catherine Joseph, Aadil Kakajiwala, Aaron Kessel, Melissa Muff-Luett, María J Santiago Lozano, Matthew Pinto, Stephanie Reynaud, Sonia Solomon, Cara Slagle, Rachana Srivastava, Weiwen V Shih, Tennille Webb, Shina Menon

Faculty, Staff and Students Publications

RATIONALE & OBJECTIVE: There are limited studies describing the epidemiology and outcomes in children and young adults receiving continuous kidney replacement therapy (CKRT). We aimed to describe associations between patient characteristics, CKRT prescription, and survival.

STUDY DESIGN: Retrospective multicenter cohort study.

SETTING & PARTICIPANTS: 980 patients aged from birth to 25 years who received CKRT between 2015 and 2021 at 1 of 32 centers in 7 countries participating in WE-ROCK (Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Diseases).

EXPOSURE: CKRT for acute kidney injury or volume overload.

OUTCOMES: Death before intensive care unit (ICU) discharge.

ANALYTICAL APPROACH: Descriptive …


The Fallacy Of Electronic Cigarettes For Tobacco Dependence, Harold J Farber, Carlos Rábade Castedo, Carlos A Jimenez-Ruiz, Manuel Conrado Pacheco Oct 2024

The Fallacy Of Electronic Cigarettes For Tobacco Dependence, Harold J Farber, Carlos Rábade Castedo, Carlos A Jimenez-Ruiz, Manuel Conrado Pacheco

Faculty, Staff and Students Publications

No abstract provided.


Psychometric Evaluation Of Clinician- And Caregiver-Reported Clinical Severity Assessments For Individuals With Cdkl5 Deficiency Disorder, Jacinta M Saldaris, Peter Jacoby, Jenny Downs, Eric D Marsh, Helen Leonard, Elia Pestana-Knight, Rajsekar Rajaraman, Judith Weisenberg, Bernhard Suter, Heather E Olson, Dana Price, William Hong, Erin Prange, Tim A Benke, Scott Demarest Oct 2024

Psychometric Evaluation Of Clinician- And Caregiver-Reported Clinical Severity Assessments For Individuals With Cdkl5 Deficiency Disorder, Jacinta M Saldaris, Peter Jacoby, Jenny Downs, Eric D Marsh, Helen Leonard, Elia Pestana-Knight, Rajsekar Rajaraman, Judith Weisenberg, Bernhard Suter, Heather E Olson, Dana Price, William Hong, Erin Prange, Tim A Benke, Scott Demarest

Faculty, Staff and Students Publications

Objective: The CDKL5 Clinical Severity Assessment (CCSA) is a comprehensive, content-validated measurement tool capturing the diverse challenges of cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD), a genetically caused developmental epileptic encephalopathy (DEE). The CCSA is divided into clinician-reported (CCSA-Clinician) and caregiver-reported (CCSA-Caregiver) assessments. The aim of this study was to evaluate the factor structure of these measures through confirmatory factor analysis (CFA) and evaluate their validity and reliability.

Methods: Participants were recruited from the International CDKL5 Clinical Research Network to take part in an in-clinic CCSA-Clinician evaluation (n = 148) and/or complete the CCSA-Caregiver questionnaire (n = 198). CFA was …


Law School Announcements 2024-2025, Law School Announcements Editors Oct 2024

Distinct Landscape And Clinical Implications Of Therapy-Related Clonal Hematopoiesis, Koichi Takahashi, Daisuke Nakada, Margaret Goodell Oct 2024

Distinct Landscape And Clinical Implications Of Therapy-Related Clonal Hematopoiesis, Koichi Takahashi, Daisuke Nakada, Margaret Goodell

Faculty, Staff and Student Publications

Therapy-related clonal hematopoiesis (t-CH) is defined as clonal hematopoiesis detected in individuals previously treated with chemotherapy and/or radiation therapy. With the increased use of genetic analysis in oncological care, the detection of t-CH among cancer patients is becoming increasingly common. t-CH arises through the selective bottleneck imposed by chemotherapies and potentially through direct mutagenesis from chemotherapies, resulting in a distinct mutational landscape enriched with mutations in DNA damage-response pathway genes such as TP53, PPM1D, and CHEK2. Emerging evidence sheds light on the mechanisms of t-CH development and potential strategies to mitigate its emergence. Due to its unique characteristics that predominantly …


Dna Methylation-Derived Immune Cell Proportions And Cancer Risk In Black Participants, Christopher S Semancik, Naisi Zhao, Devin C Koestler, Eric Boerwinkle, Jan Bressler, Rachel J Buchsbaum, Karl T Kelsey, Elizabeth A Platz, Dominique S Michaud Oct 2024

Dna Methylation-Derived Immune Cell Proportions And Cancer Risk In Black Participants, Christopher S Semancik, Naisi Zhao, Devin C Koestler, Eric Boerwinkle, Jan Bressler, Rachel J Buchsbaum, Karl T Kelsey, Elizabeth A Platz, Dominique S Michaud

Faculty, Staff and Student Publications

Prior cohort studies assessing cancer risk based on immune cell subtype profiles have predominantly focused on White populations. This limitation obscures vital insights into how cancer risk varies across race. Immune cell subtype proportions were estimated using deconvolution based on leukocyte DNA methylation markers from blood samples collected at baseline on participants without cancer in the Atherosclerosis Risk in Communities Study. During a mean of 17.5 years of follow-up, 668 incident cancers were diagnosed in 2,467 Black participants. Cox proportional hazards regression was used to examine immune cell subtype proportions and overall cancer incidence and site-specific incidence (lung, breast, and …


Tau Is Required For Glial Lipid Droplet Formation And Resistance To Neuronal Oxidative Stress, Lindsey D Goodman, Isha Ralhan, Xin Li, Shenzhao Lu, Matthew J Moulton, Ye-Jin Park, Pinghan Zhao, Oguz Kanca, Ziyaneh S Ghaderpour Taleghani, Julie Jacquemyn, Joshua M Shulman, Kanae Ando, Kai Sun, Maria S Ioannou, Hugo J Bellen Oct 2024

Tau Is Required For Glial Lipid Droplet Formation And Resistance To Neuronal Oxidative Stress, Lindsey D Goodman, Isha Ralhan, Xin Li, Shenzhao Lu, Matthew J Moulton, Ye-Jin Park, Pinghan Zhao, Oguz Kanca, Ziyaneh S Ghaderpour Taleghani, Julie Jacquemyn, Joshua M Shulman, Kanae Ando, Kai Sun, Maria S Ioannou, Hugo J Bellen

Duncan NRI Faculty and Staff Publications

The accumulation of reactive oxygen species (ROS) is a common feature of tauopathies, defined by Tau accumulations in neurons and glia. High ROS in neurons causes lipid production and the export of toxic peroxidated lipids (LPOs). Glia uptake these LPOs and incorporate them into lipid droplets (LDs) for storage and catabolism. We found that overexpressing Tau in glia disrupts LDs in flies and rat neuron-astrocyte co-cultures, sensitizing the glia to toxic, neuronal LPOs. Using a new fly tau loss-of-function allele and RNA-mediated interference, we found that endogenous Tau is required for glial LD formation and protection against neuronal LPOs. Similarly, …


Considerations For Reporting Variants In Novel Candidate Genes Identified During Clinical Genomic Testing, Jessica X Chong, Seth I Berger, Samantha Baxter, Erica Smith, Changrui Xiao, Daniel G Calame, Megan H Hawley, E Andres Rivera-Munoz, Stephanie Ditroia, Genomics Research To Elucidate The Genetics Of Rare Diseases (Gregor) Consortium, Michael J Bamshad, Heidi L Rehm Oct 2024

Considerations For Reporting Variants In Novel Candidate Genes Identified During Clinical Genomic Testing, Jessica X Chong, Seth I Berger, Samantha Baxter, Erica Smith, Changrui Xiao, Daniel G Calame, Megan H Hawley, E Andres Rivera-Munoz, Stephanie Ditroia, Genomics Research To Elucidate The Genetics Of Rare Diseases (Gregor) Consortium, Michael J Bamshad, Heidi L Rehm

Faculty, Staff and Students Publications

Since the first novel gene discovery for a Mendelian condition was made via exome sequencing, the rapid increase in the number of genes known to underlie Mendelian conditions coupled with the adoption of exome (and more recently, genome) sequencing by diagnostic testing labs has changed the landscape of genomic testing for rare diseases. Specifically, many individuals suspected to have a Mendelian condition are now routinely offered clinical ES. This commonly results in a precise genetic diagnosis but frequently overlooks the identification of novel candidate genes. Such candidates are also less likely to be identified in the absence of large-scale gene …


Novel Genes Of The Male Reproductive System: Potential Roles In Male Reproduction And As Non-Hormonal Male Contraceptive Targets, Thomas X Garcia, Martin M Matzuk Oct 2024

Novel Genes Of The Male Reproductive System: Potential Roles In Male Reproduction And As Non-Hormonal Male Contraceptive Targets, Thomas X Garcia, Martin M Matzuk

Faculty, Staff and Students Publications

The development of novel non-hormonal male contraceptives represents a pivotal frontier in reproductive health, driven by the need for safe, effective, and reversible contraceptive methods. This comprehensive review explores the genetic underpinnings of male fertility, emphasizing the crucial roles of specific genes and structural variants (SVs) identified through advanced sequencing technologies such as long-read sequencing (LRS). LRS has revolutionized the detection of structural variants and complex genomic regions, offering unprecedented precision and resolution over traditional next-generation sequencing (NGS). Key genetic targets, including those implicated in spermatogenesis and sperm motility, are highlighted, showcasing their potential as non-hormonal contraceptive targets. The review …


Antitrust After The Coming Wave, Daniel A. Crane Oct 2024

Antitrust After The Coming Wave, Daniel A. Crane

Articles

A coming wave of general-purpose technologies, including artificial intelligence ("AI"), robotics, quantum computing, synthetic biology, energy expansion, and nanotechnology, is likely to fundamentally reshape the economy and erode the assumptions on which the antitrust order is predicated. First, AI-driven systems will vastly improve firms' ability to detect (and even program) consumer preferences without the benefit of price signals, which will undermine the traditional information-producing benefit of competitive markets. Similarly, these systems will be able to determine comparative producer efficiency without relying on competitive signals. Second, AI systems will invert the salient characteristics of human managers, whose intentions are opaque but …


Chenery Ii Revisited, Daniel T. Deacon Oct 2024

Chenery Ii Revisited, Daniel T. Deacon

Articles

Ever since the Supreme Court’s 1947 decision in SEC v. Chenery Corporation, known as Chenery II, agencies have enjoyed wide latitude to develop policy through individual adjudications in addition to rulemaking. Chenery II has never been completely uncontroversial, and in recent years, calls to overturn or limit it have been expressed in increasingly fervent tones. Agency policymaking by adjudication has emerged as a new front in the struggle over the administrative state.

Against the backdrop of such calls, this Article revisits some of the fundamental questions concerning the Chenery II doctrine. I argue in favor of retaining Chenery II’s core …