Digital Commons Network^™

Upregulation Of Fatty Acid Synthase Increases Activity Of Β-Catenin And Expression Of Notum To Enhance Stem-Like Properties Of Colorectal Cancer Cells, Courtney O. Kelson, Josiane Weber Tessmann, Mariah E. Geisen, Daheng He, Chi Wang, Tianyan Gao, B. Mark Evers, Yekaterina Y. Zaytseva

Markey Cancer Center Faculty Publications

Dysregulated fatty acid metabolism is an attractive therapeutic target for colorectal cancer (CRC). We previously reported that fatty acid synthase (FASN), a key enzyme of de novo synthesis, promotes the initiation and progression of CRC. However, the mechanisms of how upregulation of FASN promotes the initiation and progression of CRC are not completely understood. Here, using Apc/VillinCre and ApcMin mouse models, we show that upregulation of FASN is associated with an increase in activity of β-catenin and expression of multiple stem cell markers, including Notum. Genetic and pharmacological downregulation of FASN in mouse adenoma organoids decreases the activation of β-catenin …

The Absence Of Cxcl10 Activity Does Not Affect The Capability Of Cd8+ T Cells To Migrate And Eliminate The Tissue Cysts Of Toxoplasma Gondii From The Brains Of Chronically Infected Mice, Rajesh Mani, Yasuhiro Suzuki

Markey Cancer Center Faculty Publications

Toxoplasma gondii forms tissue cysts in neurons and astrocytes in the brain to establish chronic infection, and astrocytes express the CXCL10 chemokine in chronically infected mice. Since chemokines mediate the migration of T cells to attack their targets, and since CXCL10 plays key roles in T cell-mediated control of the proliferation of tachyzoites (the acute stage form) of T. gondii during the acute stage of infection, we examined whether CXCL10 is involved in recruiting anti-cyst CD8+ cytotoxic T cells to eliminate the cysts in their brains. We employed adoptive transfer of CD8+ immune T cells to infected, T cell-deficient SCID …

The Impact Of Pdcd4, A Translation Inhibitor, On Drug Resistance, Qing Wang, Hsin-Sheng Yang

Markey Cancer Center Faculty Publications

Programmed cell death 4 (Pdcd4) is a tumor suppressor, which has been demonstrated to efficiently suppress tumorigenesis. Biochemically, Pdcd4 binds with translation initiation factor 4A and represses protein translation. Beyond its role in tumor suppression, growing evidence suggests that Pdcd4 enhances the chemosensitivity of several anticancer drugs. To date, numerous translational targets of Pdcd4 have been identified. These targets govern important signal transduction pathways, and their attenuation may improve chemosensitivity or overcome drug resistance. This review will discuss the signal transduction pathways regulated by Pdcd4 and the potential mechanisms through which Pdcd4 enhances chemosensitivity or counteracts drug resistance.

Shsp Dean's Newsletter, Fall 2024, Robert W. Amler

SHSP Dean’s Newsletter

No abstract provided.

Gmm Estimation With Brownian Kernels Applied To Income Inequality Measurement, Jin Seo Cho, Peter C.B. Phillips

Cowles Foundation Discussion Papers

In GMM estimation, it is well known that if the moment dimension grows with the sample size, the asymptotics of GMM differ from the standard finite dimensional case. The present work examines the asymptotic properties of infinite dimensional GMM estimation when the weight matrix is formed by inverting Brownian motion or Brownian bridge covariance kernels. These kernels arise in econometric work such as minimum Cramer-von Mises distance estimation when testing distributional specification. The properties of GMM estimation are studied under different environments where the moment conditions converge to a smooth Gaussian or non-differentiable Gaussian process. Conditions are also developed for …

Welfare Accounting, Eduardo Dávila, Andreas Schaab

Cowles Foundation Discussion Papers

This paper develops a welfare accounting decomposition that identifies and quantifies the origins of welfare gains and losses in general economies with heterogeneous individuals and disaggregated production. The decomposition — exclusively based on preferences and technologies — first separates efficiency from redistribution considerations. Efficiency comprises i) exchange efficiency, which captures allocative efficiency gains due to reallocating consumption and factor supply across individuals, and ii) production efficiency, which captures allocative efficiency gains due to adjusting intermediate inputs and factors, as well as technical efficiency gains from primitive changes in technologies, good endowments, and factor endowments. Leveraging the decomposition, we provide a …

Effect Of Storage Time And Temperature On Aggregation Of Alzheimer's Disease Amyloid-Β Protein, Amy Veihdeffer

Theses and Dissertations

Amyloid-β protein (Aβ) is widely studied due to its key role in Alzheimer’s disease (AD) pathology. One characteristic of patients suffering from AD is the deposition of amyloid plaques comprised of Aβ aggregates, which are associated with synapse damage. Thus, studying Aβ aggregation and aggregation inhibition may provide pathological and therapeutic insights. Aggregation of Aβ is a nucleation dependent process that may be influenced by the presence of pre-formed Aβ aggregate seeds that can facilitate formation of protein aggregates. These seeds may appear during preparation or storage of monomer, posing impact on experiments that study the aggregation process and the …

Evaluation Of Settlement In Poorly Graded Sand With Gravel Under Strain-Controlled Cyclic Triaxial And Dynamic Centrifuge Model Testing Conditions, Elise Jones

Theses and Dissertations

This research evaluates the dynamic behavior and volume change of sand with gravel subjected to cyclic loading. Historically, research on the dynamic behavior of cohesionless soils has primarily focused on the study of liquefaction due to its known implications on soil shear strength loss. Gravelly soil is generally assumed to be less susceptible to liquefaction since its large particle size facilitates drainage during cyclic loading. Gravel’s particle size also makes it difficult to test using standard cyclic shearing laboratory equipment. Thus, there is a lack of widespread research and predictive methods for the dynamic behavior of gravelly soil. Determining the …

From Classical To Contemporary: Popular Music's Role In Shaping Opera And Vocal Training, Craig Allen

Theses and Dissertations

This dissertation advocates for the integration of contemporary popular music into classical voice education, addressing the evolving landscape of the performing arts. As the boundary between classical and popular music fades, incorporating popular elements into traditional opera training equips performers for modern industry demands.

The first chapter offers a historical analysis, tracing opera’s origins from the late 16th century and showing how popular music influenced its development. Composers incorporated folk melodies and dance rhythms into early opera, setting a precedent for blending styles. Contemporary operas, such as Nkeiru Okoye’s Harriet Tubman and Nmon Ford’s House of Orfeus, continue this tradition, …

Innovative Strategies For Healthcare Data Integration: Enhancing Etl Efficiency Through Containerization And Parallel Computing, Ehsan Soltanmohammadi

Theses and Dissertations

The healthcare industry is rapidly transforming due to technology adoption, resulting in an explosion of data. Extract, Transform, Load (ETL) processes are crucial for integrating and analyzing this data to support decision-making and enhance patient care. However, ETL processes face significant challenges, including data diversity, quality issues, security and compliance, and scalability. Opportunities exist to optimize ETL processes through advanced technologies like big data analytics, containerization, and parallel computing, improving data quality, and enhancing security. This literature review examines current ETL processes in healthcare, highlighting challenges and opportunities for future improvement, ultimately aiming to enhance healthcare outcomes and patient experiences. …

Interpretation Of Surface Roughness Of Stainless Steel 316l In Laser Powder Bed Fusion Additive Manufacturing, Tianyu Zhang

Theses and Dissertations

Laser Powder Bed Fusion (L-PBF), a widely used metal additive manufacturing (AM) method, is emerging as a key technology in the modern manufacturing industry. Its applications span across aerospace, transportation, energy, and biomedical industries, aiming to maximize product functionality, quality, and manufacturing efficiency.

Surface roughness, an important measure of product quality, impacts geometrical tolerances and plays a critical role in mechanical and functional properties. Although post-process techniques such as machining, shot peening, and chemical processing can be used to refine surfaces, internal surfaces in complex geometries remain difficult to treat, limiting part performance due to undesired surface features. The …

Leveraging The Usage Of Blockchain Towards Trust-Dominated Manufacturing Systems, Philip Joseph Samaha

Theses and Dissertations

Smart Manufacturing has elevated manufacturing processes, transitioning from automated systems to autonomous ones. This evolution has heightened the significance of data within manufacturing facilities. The role of data has evolved from solely monitoring processes to both monitoring and extracting insights from these processes, facilitating precise control. In this context, the data infrastructure plays a critical role, encompassing both internal data circulating within the facility—such as information exchanged between controllers and actuators—and external data transmitted to and from outside entities. When the factory's cyber infrastructure is connected to the internet, security concerns escalate significantly, amplifying associated risks. Therefore, the integration of …

Mechanics Based Characterization Of Elastic Metamaterials, Mamdudur Rahman

Theses and Dissertations

In bandgap engineering there is a shortage of systematic design approach which enables one to select design variables to achieve bandgap in desired frequency range. Tools that can address this can open new areas of interest, especially since phononic crystals with low frequency bandgaps have multitude of applications in attenuation of structural vibration. Furthermore, mechanics-based characterization of phononic crystals had not seen much progress in the recent years while a lot of applied research had been conducted on phononic materials with material phase periodicity and other factors taken into consideration. This work aims to propose a systematic characterization approach of …

Retrospective Of My Experience At The University Of South Carolina, Karl Dickey

Theses and Dissertations

Theatre is, by its very nature, a collaborative process. No show lives in true isolation. Even in its smallest version, it takes at least one to perform and one to listen. The theatre that is produced in the 21^st century is deeper and more complex a process than the finished and polished shows that are presented to the audience. Behind, underneath, and all around a single performer on a stage are hours of thoughtful contemplation and execution on the part of the director, designers, and fabricators. There is something to be learned and gained from every human interaction in …

Ashs To As: Evaluating The Effectiveness Of Mandatory Athletic Study Hall In Improving High School Athletes’ Academics, Angela Pilson

Theses and Dissertations

During the 2023-2024 academic year, this action research study was conducted at local, mid-sized high school in South Carolina using a mixed-methods approach to evaluate the efficacy and impact of a mandatory athletic study hall (ASH) program on high school athletes’ academic performance. Through this program, during each academic quarter, any in-season athletes with any grades below 69% to either attend after-school study hall sessions or complete tutoring. The study both reviewed the academic performance of athletes and nonathletes and collected qualitative data from stakeholder surveys completed by nonathletes, athletes, teachers, coaches, and parents. The findings revealed a significant difference …

An Examination Of Civil Asset Forfeiture In South Carolina, Jeffrey Trowbridge

Theses and Dissertations

Civil asset forfeiture allows the government to seize and forfeit property that is associated with criminal activity without arresting or charging the property owner. Although expansive in its potential application, little is understood about the characteristics of civil asset forfeiture cases, the property owners involved in forfeiture cases, or the characteristics of any criminal cases pursued parallel to the civil cases. Utilizing open-source, public court records, this dissertation provides an exploratory analysis of these gaps in the literature by examining the types of civil asset forfeiture used, the value of asset forfeiture cases, how money from asset forfeiture is divided …

Bridging Disciplinary Boundaries: A Study On The Integration Of Social Studies Within Elementary Ela Education, Jill Knight

Theses and Dissertations

This qualitative action research study investigates the integration of social studies within English Language Arts (ELA) education, highlighting the challenges educators face in balancing curriculum demands amid increasing literacy and math instruction pressures. With over 20 years of experience teaching high school history, the researcher identified a concerning decline in social studies education at the elementary level, a situation worsened by legislative measures such as No Child Left Behind (NCLB) and the Every Student Succeeds Act (ESSA), which prioritize tested subjects. The primary aim of this study was to collaborate with elementary teachers to explore their perceptions and experiences related …

Bayesian Nonparametric Models For Pooled Data, Yizeng Li

Theses and Dissertations

This work examines two applications of pooling: group testing and pooled biomonitoring. Group testing, introduced by Dorfman in the early 1940s, was initially developed to screen for syphilis among U.S. inductees during World War II. Since then, the approach has demonstrated cost-saving benefits in diverse fields, including drug discovery, genetics, and infectious disease testing. While various regression methods—parametric, nonparametric, and semiparametric—have been proposed to analyze group testing data, they fall short in addressing age-related disparities in disease presence if such variations exist. In Chapter 2, we address this gap by expanding varying coefficient regression within a Bayesian framework to accommodate …

Investigating Student Engagement Through The Implementation Of A Performance Task In Secondary Mathematics: A Mixed Methods Action Research Study, Sulema Wright

Theses and Dissertations

Through teaching experiences in the math classroom, students voiced that solving mathematical problems did not benefit them in the real-world. This study discussed the use of a performance task in a high school geometry class as a way to engage students, increase their confidence when solving math problems, and determine the impact they have on engagement compared to supportive assignments. Students' perspectives were used as one measure in determining engagement, alongside, my perspective of using a tally table. Through the use of a performance task that connected to the life experiences, students’ perspectives proved that implementation increased their engagement in …

Inspecting The Foundations Of Natural Law Ethics And Politics: Looking For Cracks, Detecting Gaps, And Considering The Edifice That Can Be Built Thereon, Adam D. Bailey

Theses and Dissertations

In this dissertation I inspect the foundations of natural law ethics and politics. The inspection involves looking for cracks, detecting gaps, and considering the edifice that can be built thereon. To do so, I critically examine several of the many concepts and principles that are constitutive of those foundations. Some of my examination is done by means of direct consideration of such concepts and principles. And some of it is done by addressing such concepts and principles indirectly as I address questions about practical ethical or political concerns including: how can public officials make decisions that are not biased, what …

Nurturing Multiracial Identity: A Community Of Practice Approach To Developing Culturally Responsive Pedagogy And Seeking Curriculum Justice For Multiracial Learners, Laura Althea Mosman Smith

Theses and Dissertations

This action research dissertation examines the impact of participation in a community of practice on teachers' beliefs and behaviors regarding the selection of representative curriculum and building culturally responsive pedagogy, especially when considering the growing population of multiracial learners in U.S. classrooms. The study involved 4 English Language Arts teachers in an Upper Elementary School engaging in a comprehensive text audit followed by the application of the critical redesign cycle to modify the curriculum, aiming to better address the needs of multiracial learners. Data was collected through surveys, interviews, and observations over six Community of Practice meetings to assess changes …

Panic At The Library: Origins And Manifestations Of Library And Technology Anxiety In High School Sophomores, Kelly A. Guistwhite

Theses and Dissertations

Constance Mellon formally identified library anxiety in the mid-1980s. Library anxiety can result in students avoiding the library, its resources, and its staff. Students with library anxiety perform worse on academic tasks than their more comfortable peers. Library anxiety causes procrastination on assignments and undermines academic success. Technology anxiety has evolved with library anxiety changing as new information technology becomes available. This exploratory research investigated to what extent library and technology anxiety manifests among sophomore students, the relationship between library anxiety and technology anxiety, and the perception of online services at Maple Bluff and Scarlett Woods High Schools. This study …

The State Math Assessment, I-Ready Diagnostic, And The State Accountability Plan: Is This An Assessment System To Support Learning For All Students?, Beverly Quinn

Theses and Dissertations

This study examined the relationship between a state high-stakes summative mathematics assessment and an interim third-party math diagnostic assessment and data literacy among teachers in a Southeastern school district. Despite ongoing federal and state accountability efforts, the gap between policy intentions and student achievement continues to grow. In this quantitative correlational study, the relationship between the Spring 2023 state summative and interim assessment data for fourth and eighth-grade students was examined. Additionally, the Teacher Data Usage Survey (TDUS) responses were analyzed to examine how teachers utilize assessment data in instructional practices. Data were reported as percentages of responses per category …

Why He Sings: An Action Research Study Using Counternarratives To Affect The Deficit Narratives Attributed To Students Of Color, Tiffany Jones Early

Theses and Dissertations

There is ample research that shows that students of color are less likely to graduate from college than their White peers. Meanwhile, the demographics of students who enroll in college continue to be more diverse than previous generations. As universities struggle to understand retention disparities, the voices of the students are often eliminated from the discussion. Many university staff members, instead, opt for a deficit narrative to blame what they believe students of color lack that inhibits them from persisting in college until graduation. The purpose of this study is to use narrative inquiry to better understand the educational experiences …

You're Not The Only One Who Can Teach Us: Teacher Facilitation In Three Secondary School Music Contexts, David Dwight Bowman

Theses and Dissertations

Over the last half-century, school music reforms have focused more on content than process, and the directive teaching that serves as the dominant method used by secondary school music teachers is not adequately meeting the needs of the students who currently occupy American high schools. To improve teaching practice in one such high school, an action research study was conducted to investigate the use of facilitative teaching strategies, how those teaching strategies impact students’ learning experience, and what the perceived impacts of those strategies are. A qualitative case study methodology was employed to determine how an intervention period of facilitative …

Fragmentation In Global Climate Governance: What Lessons From Covid-19?, Sivan Shlomo Agnon

Vanderbilt Journal of Transnational Law

No abstract provided.

Closing The Asylum Gender Gap: Why "Afghan Women" Is A Compelling Particular Social Group, Mackenzie Heinrichs

Vanderbilt Journal of Transnational Law

No abstract provided.

The Scientific Border: Dna Testing For Family Reunification, Alexa Greco

Vanderbilt Journal of Transnational Law

No abstract provided.

The International Copyright System And Development: The Role Of The World Intellectual Property Organization, Faith O. Majekolagbe

Vanderbilt Journal of Transnational Law

No abstract provided.

Ultra-Slow Responses To The Ultra-Fast Fashion Problem: Combatting Forced Labor In The Global Apparel Industry With Due Diligence And Customs Regulations, Cameron Watts

Vanderbilt Journal of Transnational Law

No abstract provided.