Digital Commons Network^™

Sall4 And Gata4 Induce Cardiac Fibroblast Transition Towards A Partially Multipotent State With Cardiogenic Potential, Hong Gao, Saliha Pathan, Beverly R E A Dixon, Aarthi Pugazenthi, Megumi Mathison, Tamer M A Mohamed, Todd K Rosengart, Jianchang Yang

Faculty, Staff and Students Publications

Cardiac cellular fate transition holds remarkable promise for the treatment of ischemic heart disease. We report that overexpressing two transcription factors, Sall4 and Gata4, which play distinct and overlapping roles in both pluripotent stem cell reprogramming and embryonic heart development, induces a fraction of stem-like cells in rodent cardiac fibroblasts that exhibit unlimited ex vivo expandability with clonogenicity. Transcriptomic and phenotypic analyses reveal that around 32 ± 6.4% of the expanding cells express Nkx2.5, while 13 ± 3.6% express Oct4. Activated signaling pathways like PI3K/Akt, Hippo, Wnt, and multiple epigenetic modification enzymes are also detected. Under suitable conditions, these cells …

Exploring The Impact Of Lighting Sources On Walking Behavior In Obstructed Walkways Among Older Adults, Yue Luo, Yuhao Chen, Gaojian Huang, Boyi Hu

Faculty Research, Scholarly, and Creative Activity

The pandemic has reinforced older adults' reliance on their homes and the concept of “aging in place”. Changes like reduced physical strength and cognitive deficit, however, have heightened the challenge of simple tasks like obstacle crossing among older adults, let alone when older adults cannot perceive the surroundings well during the nighttime. The study is, therefore, to evaluate the impact of lighting on older adults' obstacle-crossing behavior during the nighttime. Twenty-seven older adults (81 ± 6 yrs., 171 ± 12 cm, 75 ± 20 kg, 14 females) were recruited. Participants were asked to cross over the obstacle in a dark …

Reliability Of Mpmri In Diagnosing Cancer Prostate Following Intravesical Bcg For Bladder Cancer, Arjun Ponavudaiappan, Pushan Prabhakar, Andrew Renshaw, Ahmed Eldefrawy, Murugesan Manoharan

All Publications

Background: Detecting carcinoma prostate (CaP) after intravesical Bacillus Calmette Guerin (BCG) immunotherapy for non-muscle invasive bladder cancer (NMIBC) poses diagnostic challenges. Granulomatous prostatitis (GP) has an incidence of 0.8%-3.3% in post-intravesical BCG patients and 6% incidence in a PIRADS 5 lesion on multiparametric MRI (mpMRI). Patients with GP after intravesical BCG may have clinical, biochemical, and radiological features similar to CaP. In our study, we evaluate the reliability of mpMRI in diagnosing CaP after intravesical BCG therapy.

Materials and methods: We reviewed the NMIBC patients treated with intravesical BCG therapy between 2017 and 2023 and investigated those who underwent mpMRI …

Social Determinants Of Health Affect Psychological Distress Among People With Disabilities, Jessica Kersey, Amie Devlin, Sarah Shyres, Emily A Kringle, Ashley J Housten

2020-Current year OA Pubs

People with disabilities experience inequitable exposure to social determinants of health (SDOH) that contribute to disparate health outcomes, including psychological distress. There is little research examining which SDOH have the strongest effect on psychological distress among people with disabilities. This leaves healthcare providers and policy makers with insufficient information to make well-informed treatment decisions or allocate resources effectively. We explored the association between SDOH and disability and which factors may moderate the association between disability and psychological distress. Using data from the US Census Bureau's Household Pulse Survey (Phase 3.5), we examined SDOH among people with and without disability (

Adipocyte Lipin 1 Expression Associates With Human Metabolic Health And Regulates Systemic Metabolism In Mice, Andrew Lapoint, Jason M. Singer, Daniel Ferguson, Trevor M. Shew, M. Katie Renkemeyer, Hector H. Palacios, Rachael L. Field, Gordon I. Smith, Mai He, Gary J Patti, Samuel Klein, Jonathan R. Brestoff, Brian N. Finck, Et Al.

2020-Current year OA Pubs

Dysfunctional adipose tissue is believed to promote the development of hepatic steatosis and systemic insulin resistance, but many of the mechanisms involved are still unclear. Lipin 1 catalyzes the conversion of phosphatidic acid to diacylglycerol, the penultimate step of triglyceride synthesis, which is essential for lipid storage. Herein we found that adipose tissue LPIN1 expression is decreased in people with obesity compared with lean subjects, and low LPIN1 expression correlated with multi-tissue insulin resistance and increased rates of hepatic de novo lipogenesis. Comprehensive metabolic and multiomic phenotyping demonstrated that adipocyte-specific Lpin1-/- mice had a metabolically unhealthy phenotype, including liver and …

Lessons Learned From The Conduct Of Inpatient Clinical Trials In A Pandemic, Jane A. O'Halloran, Jeremy R. Beitler, Lucy K. Chung, Mamta K. Jain, Akram Khan, Lisa H. Merck, Ahmad Mourad, Minn A. Oh, Shweta Sharma, Tammy Yokum, Seema U. Nayak

2020-Current year OA Pubs

No abstract provided.

The Utility Of Indocyanine Green Angiography In Breast Reconstruction To Detect Mastectomy Skin Flap Necrosis And Free Flap Perfusion: An Umbrella Review, Nicholas Fadell, Flora Laurent, Sai Anusha Sanka, Esther Ochoa, Lauren Yaeger, Xiaowei Li, Matthew D Wood, Justin M Sacks, Saif Badran

2020-Current year OA Pubs

Two of the greatest challenges in breast reconstruction are mastectomy skin flap necrosis (MSFN) and autologous flap failure. This review summarizes current evidence regarding the usage of indocyanine green angiography (ICGA) in breast reconstruction, identifies knowledge gaps, and provides directions for future studies. An umbrella review was conducted to identify related syntheses in Embase, Ovid Medline, Scopus, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, and the Clinical Trials databases. Data were extracted from systematic reviews (SRs) and meta-analyses (MAs) that discussed the use of ICGA in breast reconstruction. Sixteen syntheses were included (10 SRs …

Molecular Detection And Genomic Characterization Of Samak Micromys Paramyxovirus-1 And -2 In Micromys Minutus, Republic Of Korea, Augustine Natasha, Sarah E Pye, Carolina B López, Qq Et Al.

2020-Current year OA Pubs

BACKGROUND: The discovery of viruses in small mammalian populations, particularly rodents, has expanded the family Paramyxoviridae. The overlap in habitats between rodents and humans increases the risk of zoonotic events, underscoring the importance of active surveillance. Rodent species, such as Apodemus agrarius, are natural hosts for Paramyxoviridae in the Republic of Korea (ROK). However, it is unknown whether Paramyxoviridae is present in Micromys minutus, another common rodent.

METHOD: Here, we screened M. minutus collected from the Gangwon Province in the ROK for paramyxoviruses using nested polymerase chain reaction and confirm positive samples by next-generation metagenomic sequencing. Complete paramyxovirus genomes were …

Molecular Detection And Genomic Characterization Of Samak Micromys Paramyxovirus-1 And -2 In Micromys Minutus, Republic Of Korea, Augustine Natasha, Sarah E Pye, Carolina B López, Et Al.

2020-Current year OA Pubs

BACKGROUND: The discovery of viruses in small mammalian populations, particularly rodents, has expanded the family Paramyxoviridae. The overlap in habitats between rodents and humans increases the risk of zoonotic events, underscoring the importance of active surveillance. Rodent species, such as Apodemus agrarius, are natural hosts for Paramyxoviridae in the Republic of Korea (ROK). However, it is unknown whether Paramyxoviridae is present in Micromys minutus, another common rodent.

METHOD: Here, we screened M. minutus collected from the Gangwon Province in the ROK for paramyxoviruses using nested polymerase chain reaction and confirm positive samples by next-generation metagenomic sequencing. Complete paramyxovirus genomes were …

Effect Of Sex And Age On Knee Strength In Young Athletes: A Systematic Review And Meta-Analysis, Hui Gao, Xiaoquan Luo

International Journal of Exercise Science

International Journal of Exercise Science 17(6): 1461-1477, 2024. The purpose was to summarize the studies examining knee strength in young athletes and provide valuable insights into the magnitude of changes in knee flexion and extension strength during the transition from pre-puberty to puberty among male and female athletes. The literature search was conducted through Cochrane Library, Embase, PubMed, Web of Science. Cohen’s effect size (ES) and 95% confidence intervals (CIs) were computed using a random effects model. While comparing males and females, as well as pre-puberty and puberty stages, we conducted subgroup analyses for pre-puberty versus puberty and for males …

Deacon C. Lester "Les" Parrish

African American Funeral Programs

Funeral Program for Deacon C. Lester "Les" Parrish in 1999 at Bethel Primitive Baptist Church

Anthropogenic Impacts On Aquatic Organisms, Alexis Khursigara

Sustainability Seminar Series

Aquatic environments are often dynamic, experiencing shifts in a multitude of anthropogenic stressors related to climate change and contaminant loads. Aquatic organisms, such as fish and invertebrates, must cope with these changes that can be rapid or gradual, acute or chronic, and often co-occurring. Understanding how well aquatic organisms tolerate these shifts is imperative for management practices. In this presentation, Dr. Khursigara will discuss how different anthropogenic stressors alter the physiology and behavior of multiple fish and aquatic invertebrate species.

The Lymphedema Treatment Act: Past, Present, And Future, Candace Alexander, Leigh Ann Foster, Susan Gordon, Runzun Shetye

Oncology Rehabilitation in Practice

No abstract provided.

Rewiring Our Psychologically Informed Physical Therapy Interventions: Triple Network Model, Immunology, Sex, And Pain Perception, Roberto Sandoval, Mary Lou A. Galantino

Oncology Rehabilitation in Practice

No abstract provided.

Vestibular Rehabilitation Considerations For Chemotherapy-Induced Vestibulotoxicity: A Clinical Perspective, Tabitha Galindo

Oncology Rehabilitation in Practice

No abstract provided.

The Role Of Cancer Rehabilitation In Chemotherapy-Induced Sarcopenia, Tracy L. Moore, Jessica Bertram

Oncology Rehabilitation in Practice

No abstract provided.

Perceptions And Outcomes Of Older Adults Following A Cancer Prevention Educational Seminar, Lori Boright, Sara Arena, Christopher M. Wilson, Andrew Boardman, Kevin Chen, Marcel Soleimani, Hannah Wickersham

Oncology Rehabilitation in Practice

Introduction: 19.9 million new cancer cases and 9.7 million cancer deaths occurred globally in 2023. 90-95% of cancers originate from environment and lifestyle choices. Age is a prominent non-modifiable risk factor for cancer development, so it is essential that older adults are informed on lifestyle factors affecting their cancer risk. Physical therapists (PTs) play a major role in educating and advocating for healthy cancer preventive behaviors. The purpose of this study was to describe outcomes of an educational intervention relating to cancer prevention in community-dwelling older adults.

Methods: Investigators developed and delivered a cancer prevention educational seminar relevant to exercise, …

Cover, Table Of Contents, President's Message, Editorial Board's Message, Academy Of Oncologic Physical Therapy

Oncology Rehabilitation in Practice

No abstract provided.

Effect Of Fertilizer Application On Soil Organisms Under Pasture, K W. Perrott, S U. Sarathchandra, A Lee

IGC Proceedings (1977-2023)

Effects of nutrients and phosphate fertiliser on soil microbial biomass and several groups of soil organisms were determined in a glasshouse and field experiment. Extreme depletion of soil phosphorus nitrogen or sulphur caused a decline in the soil microbial biomass. This appeared to result from lower plant growth rather than directly through nutrient depletion. No long-term effects of superphosphate (SSP) or North Carolina phosphate rock (NCPR) on numbers of earthworms or soil micro-organisms were found in a field experiment where treatment differences had been maintained for 3 years. However, soil samples taken from fertilised plots 14 days after topdressing had …

Cadmium Accumulation In New Zealand Pastoral Agriculture, A.H C. Roberts, R D. Longhurst, M W. Brown

IGC Proceedings (1977-2023)

The accumulation of cadmium (Cd) in New Zealand agriculture was investigated principally in a national survey of pastoral soils. A total of 398 sites were sampled covering most major provinces in both North and South Islands: 312 pastoral farms and 86 "native" sites. The native sites were native bush, reserves, parks or other non­agricultural areas which were representative of the soil groups sampled on farms, The overall average total Cd content (0-7.5 cm depth) for native soils was 0.20 µgig Cd (range 0.02-0,77 µgig Cd), while the corresponding average content for pastoral soils was 0.44 µgig Cd (0.04-1.53 µgig Cd). …

Use Of Forage Nitrate-Nitrogen To Improve Nitrogen-Use Efficiency In Coastal Bermudagrass, S R. Wilkinson, M H. Frere

IGC Proceedings (1977-2023)

Coastal bermudagrass (Cynodon dactylon L. Pers.) is an important warm-season perennial grass in the Southern Piedmont of the USA. It has a high production potential, a consequent high N fertiliser requirement and is often recommended as cover for waste management systems. Forage NO3-N was correlated with dry matter yield, and drainage water with NO3-N concentration. Log forage NO3-N was significantly correlated with yield (R2=0,83) and with log soil water NO3-N (R2 .. 0.76) (P<0.01). Yields of bermudagrass associated with accumulation of IO mg NO3-N/I in shallow ground water were less than 75% of maximum, Bermudagrass growth modelling studies suggest that about 50% of maximum yield is the point of greatest N­use efficiency. This may approximate the upper limit of N application for the long term if excessive NO3-N concentration in shallow ground water Is to be prevented. Forage tissue testing for NO3-N may be useful for indicating when N-use efficiency is declining and when excess NO3-N accumulation in the soil may be expected.

Continuous High Production In The Meadow By Introduction Of Seasonal Grazing, H Murakami, H Iwama, K Okamoto

IGC Proceedings (1977-2023)

Two meadows were equally fertilised and used for haymaking since their establishment in 1966. The dry matter (DM) yield decreased gradually after the establishment of the meadows and reached a stable low level around 1974, when the autumn-saved pasture (ASP) winter grazing system was introduced to one of them !ASP meadow). The productivity of the meadow for only haymaking (HM meadow) remained low (9 t/ha), whereas the productivity of the ASP meadow recovered rapidly to a high level (13 Uha). DM yield and nutrient absorption by grass in the ASP meadow (N:242, P2O5:97, K1O:412 kg/ha) were about 1.5 times as …

Correspondence Between Vegetation And Soil In An Open Grassland, K Torok

IGC Proceedings (1977-2023)

Within the framework of a project to assess the condition of the communities in a nature reserve, soil variables were compared to vascular species composition of 3 andesite grassland sites. Fifty-five plots were sampled for species cover and for 17 soil variables, Characteristic indicator values (CIV) of each relev6 was also calculated for temperature, moisture, reaction and nitrogen based on species ecological indicator values. In this way 3 data sets have been subjected to multivariate analyses in order to detect dissimilarity among sites. The results show that the measured soil variables have an impact upon species composition: the stands are …

Fate Of Urinary Nitrogen On Peat Soils Under Contrasting Conditions, T J. Clough, S F. Ledgard, K C. Cameron, R R. Sherlock

IGC Proceedings (1977-2023)

In the Waikato district of New Zealand, large areas of peat soils are used for pastoral agriculture. This study examined the urinary nitrogen (N) transformations after application of ISN•labelled urine to peat soils at 2 stages of development, with and without a water table present. The peat soil with the longest development history had greater plant recovery of urine N but also had greater denitrificalion losses. The presence of a water table reduced both immobilisation and plant uptake of urinary N and increased loss by denitrification.

Studies On Soil Microbial Biomass Carbon, Nitrogen And Phosphorus In Three Crop Rotation Systems, A Garcia, D A. Moron

IGC Proceedings (1977-2023)

Amount and dynamics of microbial biomass were studied in 3 different agricultural systems which has been cropped for 27 years on a mollisol. Plots were sampled 5 times between June 1989 and January 1990, Average microbial biomass was higher in the pasture-crop system than in the continuous crop system, Seasonal variations in biomass were related to periods of active plant growth and warmer temperatures. Quantities of nitrogen (N) and phosphorus (P) immobilised in soil biomass were also higher in the crop pasture system and were linearly related to biomass carbon. Mean annual fluxes through biomass (20 cm depth) were estimated …

Field Evaluation Of Partially Acidulated Phosphate Rocks As Fertilizers For Permanent Pastures, S.S S. Rajan, S F. Ledgard, B S. Thorrold

IGC Proceedings (1977-2023)

Seven field trials were conducted, in soils of volcanic origin, to evaluate the agronomic effectiveness of partially acidulated phosphate rocks (PAPRs), as influenced by type of acidulant, degree of acidulation, fineness of grinding and reactivity of phosphate rock, and hardness of the granules, Pasture dry matter production results indicated that sulphuric PAPRs of 30% and SO% acidulation prepared from unground North Carolina rock were less effective than superphosphate. When reactive rocks were finely ground, 20% phosphoric acidulated product was generally as effective as superphosphate, and there was no apparent difference between the products prepared from North Carolina and a less …

Improving The Efficiency Of Nitrogen Utilization In A Grassland Soil With Different Mixtures Of Pasture Species, B E. Ruz-Jerez, P Roger Ball, R E. White

IGC Proceedings (1977-2023)

Pasture composition, herbage yield and symbiotic nitrogen fixation were compared in traditional grasslands (either based on fertiliser N or legumes) and a grassland system (herbal Icy) based on a mixture of legumes, non-aggressive grasses and deep-rooting herbs. Herbal Icy was the most efficient system in terms of herbage production per unit of N input, offering the possibility of sustaining a high level of pasture production without fertiliser N and hence reducing the risk of N losses to the environment.

Pasture Sulphur Recovery And Transformations Of Sheep Urinary Sulphur In Irrigated Soils Of Canterbury, New Zealand, M L. Nguyen, K M. Goh

IGC Proceedings (1977-2023)

A field plot trial was conducted on irrigated pasture of a Templeton silt loam soil (Udic Ustochrept) by applying 3Ssulphur (358)-labelled urine (250 µCi/g S with 1300 µSimi urine) to field plots (600x600 mm) at a rate normally occurring in sheep urine patches (150 ml in 0.03 m1). Results showed that 27 days after urine application, approximately 55- 90% of 35S-labelled urine was incorporated into soil sulphate (SO4)-S, ester SO 4-S and carbon-bonded S fractions within the major rooting zone (0-300 mm), Labelled-S was found to a soil depth of 500 cm during a 271-day period, showing that these S …

Factors Affecting Plant Sulphur Requirements In New Zealand Pastoral And Arable Systems, M L. Nguyen, K M. Goh

IGC Proceedings (1977-2023)

This paper reviews major factors affecting sulphur (S) cycling in New Zealand pastoral and arable· systems and identifies areas of research required to improve the efficient use of S fertilisers and soil S reserves. In the grazed pastoral system, S removal in animal products constitutes a small fraction of total S output while S leaching losses and excreta! S transfer losses to stock camps are substantial. Although grazing animals may cause a considerable S loss from the system, they enhance the oxidation of elemental S. Accumulated soil organic S due to the return of animal excreta and long-term annual applications …

An Overview Of Pasture Response, Nutrient Turnover And Nutrient Accumulation On The Grazed, Long-Term Superphosphate Trial At Winchmore, New Zealand, R J. Haynes, P H. Williams

IGC Proceedings (1977-2023)

The results of a long-term grazed, border dyke-irrigated trial studying the effects of annual maintenance rates of superphosphate (0, 188 and 376 kg/ha) for 40 years are outlined and discussed. Superphosphate applications increased pasture dry matter yields and this was attributed to a response to both added P and S. There was a build-up of soil organic matter over the duration of the experiment which was greater for the superphosphate treatments than control. Grazing sheep caused a redistribution of nutrients across experimental plots due to their behaviour of camping on the raised level areas of the plots. A balance sheet …