Digital Commons Network^™

Systematic Review Of Immune Checkpoint Inhibitor-Related Gastrointestinal, Hepatobiliary, And Pancreatic Adverse Events, Malek Shatila, Hao Chi Zhang, Anusha Shirwaikar Thomas, Antonio Pizuorno Machado, Sidra Naz, Nitish Mittal, Christine Catinis, Krishnavathana Varatharajalu, Carolina Colli Cruz, Eric Lu, Deanna Wu, Julie R Brahmer, Franck Carbonnel, Stephen B Hanauer, Bret Lashner, Bryan Schneider, John A Thompson, Michel Obeid, David P Farris, Yinghong Wang

Faculty, Staff and Student Publications

Gastrointestinal immune-related adverse events (GI irAEs) are common manifestations of immune checkpoint inhibitor (ICI) toxicity. We present a comprehensive systematic review of the incidence, management, and clinical course of irAEs across the entire GI system, including the luminal GI tract, liver, and pancreas. MEDLINE, Embase, Web of Science Core Collection, and Cochrane Library were used to conduct this review. All studies pertaining to GI irAEs were included. Both abstracts and full manuscripts were eligible if they included human subjects and were written in the English language. Articles not available in English, animal studies, or research not specific to GI toxicity …

The Compositions Derived From By Changing Variable In Singular Distributions, Emi̇n Özçağ

Turkish Journal of Mathematics

In this paper we concern further results of \cite{kn:oz9,kn:oz8} by using the method mainly related to the finite part of divergent integral, in fact we consider the powers for positive integers of the composition of the Dirac delta function and an infinitely differentiable function having any number of distinct multiple roots which will be defined as the neutrix limit of the regular sequence $\delta^k_n(f(x))$. Moreover we show that the powers of the composition $\delta(f(x))$ for negative integers can be also defined via neutrix settings. Some compositions as examples to better understand will be given.

African American Women’S Lived Experiences With Obstetrics/Gynecology Services In Atlanta, Georgia, Audrey M. Blake

Walden Dissertations and Doctoral Studies

African American women in Georgia die during the perinatal period at almost three times the rate of other ethnic groups. Adverse maternal outcomes demonstrate a disparity among African American women. In this phenomenological qualitative study, the lived experiences of African American women receiving obstetrical and gynecological (OB/GYN) care in the Atlanta, Georgia, Metropolitan area were explored. The study included women who identified as African American, ages 18 – 45 years old, receiving OB/GYN care in Georgia. No income limits were applied, allowing women across income levels to be included. Feagin’s systemic racism theory, along with Greenwald and Krieger’s implicit bias …

Relationship Of Cyber Threat Intelligence And Critical Infrastructure Assets On Information Technology Critical Infrastructure Attacks, Albert Su

Walden Dissertations and Doctoral Studies

Ransomware cyberattacks on critical infrastructure can disrupt critical services with the capacity to impact human lives. Some security operations center (SOC) analysts feel overwhelmed by the influx of threat indicators of compromise (IoC), making it challenging to discern which alerts are significant for their organization. Grounded in John Boyd's OODA (Observe, Orient, Decide, Act) theoretical framework, the purpose of this quantitative correlational study was to examine the relationship between cyber threat intelligence (CTI) and critical infrastructure assets on information technology critical infrastructure attacks. Data were collected by ingesting information from a U.S. CTI vendor and alerting IoCs related to critical …

Exploring The Wealth Creation Struggles Of Black Millennials, Jasmine Allen

Walden Dissertations and Doctoral Studies

The equity gap for Black millennials continues to lag compared to other racial groups. The purpose of this qualitative study was to understand the experiences of Black millennials in navigating the landscape of quality internships, high-paying careers, and generational wealth through the lens of individual, interpersonal, organizational, and community system levels. Using a narrative approach, the qualitative analysis of narratives from eight participants who have experienced these obstacles is presented. A purposive sampling technique through social media platforms was used. This study was guided by Bronfenbrenner’s ecological systems theory. Thematic analysis was employed. The themes were (a) limited exposure, (b) …

Innovation Strategies To Develop A Sustainable Municipal Government Beyond A Financial Crisis, Vickie Michelle Riggins Medina

Walden Dissertations and Doctoral Studies

Some government leaders lack knowledge of innovation strategies to develop a sustainable municipal government through a financial crisis. The purpose of this qualitative multiple-case study was to explore innovation strategies municipal government leaders employed to help overcome a financial crisis. The research question explored what innovation strategies municipal government leaders employ to help overcome a financial crisis. Argyris and Schön’s organizational learning theory of action provided the conceptual framework for this study. A purposeful sample of 10 participants included municipal government leaders and elected officials. Data were collected through semistructured open-ended interview questions, which elicited responses of shared experiences in …

The Future Of Flying: An Exploration Of New Aircraft Design And Energy Required To Support Advanced Air Mobility – Part 1, Sarah Nilsson

Publications

Lecture exploring new aircraft design and energy required to support advanced air mobility.

Und Leads Implementation Team Meeting Agenda — November 14, 2024, University Of North Dakota

LEADS Implementation Documents

Agenda for the November 14, 2024 meeting of the UND LEADS Implementation Team. The agenda includes subgroup reports and discussion of campus outreach, messaging, and marketing related to UND LEADS implementation.

Conference Report: Review Of Clinical Implementation Of Advanced Quantitative Imaging Techniques For Personalized Radiotherapy, Yevgeniy Vinogradskiy, Houda Bahig, Nicholas Bucknell, Jeffrey Buchsbaum, Hui-Kuo George Shu

Department of Radiation Oncology Faculty Papers

The topic of quantitative imaging in radiation therapy was presented as a "Masterclass" at the 2023 annual meeting of the American Society of Radiation Oncology (ASTRO). Dual-energy computed tomography (CT) and single-positron computed tomography were reviewed in detail as the first portion of the meeting session, with data showing utility in many aspects of radiation oncology including treatment planning and dose response. Positron emission tomography/CT scans evaluating the functional volume of lung tissue so as to provide optimal avoidance of healthy lungs were presented second. Advanced brain imaging was then discussed in the context of different forms of magnetic resonance …

Steering Minutes 11/14/2024, Steering Committee

Steering Committee

No abstract provided.

How Secondary Disciplinary Teachers Integrate Literacy Strategies To Improve Outcomes On State Assessments, Miracle T. Brewington

Walden Dissertations and Doctoral Studies

According to recent research, secondary disciplinary teachers’(DTs) role in increasing disciplinary literacy skills is vital. The problem in this urban school district in the Southern United States was that middle school DTs acknowledge they struggle to integrate literacy strategies in their specific disciplines to improve reading outcomes on state assessments. Guided by Shanahan and Shanahan’s disciplinary framework and Knowles’s theory of andragogy, the purpose of this study was to investigate DTs’ perceptions on integrating literacy strategies to improve reading outcomes on state assessments. A basic qualitative design was used with 10 purposefully selected secondary DTs using one-to-one, semistructured interviews. Data …

African American Women’S Lived Experiences With Obstetrics/Gynecology Services In Atlanta, Georgia, Audrey M. Blake

Walden Dissertations and Doctoral Studies

African American women in Georgia die during the perinatal period at almost three times the rate of other ethnic groups. Adverse maternal outcomes demonstrate a disparity among African American women. In this phenomenological qualitative study, the lived experiences of African American women receiving obstetrical and gynecological (OB/GYN) care in the Atlanta, Georgia, Metropolitan area were explored. The study included women who identified as African American, ages 18 – 45 years old, receiving OB/GYN care in Georgia. No income limits were applied, allowing women across income levels to be included. Feagin’s systemic racism theory, along with Greenwald and Krieger’s implicit bias …

Oncolytic Virotherapies And Adjuvant Gut Microbiome Therapeutics To Enhance Efficacy Against Malignant Gliomas, Natalie M Meléndez-Vázquez, Candelaria Gomez-Manzano, Filipa Godoy-Vitorino

Faculty, Staff and Student Publications

Glioblastoma (GBM) is the most prevalent malignant brain tumor. Current standard-of-care treatments offer limited benefits for patient survival. Virotherapy is emerging as a novel strategy to use oncolytic viruses (OVs) for the treatment of GBM. These engineered and non-engineered viruses infect and lyse cancer cells, causing tumor destruction without harming healthy cells. Recent advances in genetic modifications to OVs have helped improve their targeting capabilities and introduce therapeutic genes, broadening the therapeutic window and minimizing potential side effects. The efficacy of oncolytic virotherapy can be enhanced by combining it with other treatments such as immunotherapy, chemotherapy, or radiation. Recent studies …

The Effects Of Full-Body Photo-Editing On Female Body Image, Claire E. Mcelhern

Master's Theses

Over the past decade, the use of photo-based social media sites has seen an exponential increase. Although these sites can be beneficial for connecting with others, the editing and modification of images posted to social media has also produced adverse effects on some who use them. The aim of the present study was to assess whether partaking in a full-body photo-editing task would have a significant effect on weight dissatisfaction, appearance dissatisfaction and body confidence, compared to a control condition. Female college participants were first asked about their general Instagram use, and then were given a baseline Visual Analog Scale …

Information About A Racial Demographic Shift May Influence Tolerance For Outgroup Contact, Yvonne N. Phan

Master's Theses

When exposed to information about a demographic shift towards a non-White majority in America, White individuals tend to prefer interactions and settings within their own ethnic group over minority ethnic groups. This behavior may suggest that future inter-racial dynamics in the U.S. could be characterized by resistance from White individuals. To understand how other racial groups respond to information about a racial demographic shift, I collected data on three measures of outgroup tolerance from a multiracial sample of students from San Jose State University’s participant database after exposing them to information about a racial demographic shift driven by a Hispanic …

No Change In Functional Ecology Or Body Size In Response To A Global Climate Event In The Late Maastrichtian Owl Creek Formation, William T. Rizza

Master's Theses

During the last 300 ka of the Maastrichtian, global temperatures increased and decreased by ~2℃, likely caused by a pulse of Deccan volcanism. The Owl Creek Type Section in Mississippi records some portion of the last 400 ka of the Late Maastrichtian. It is expected that marine invertebrates will demonstrate a taxonomic, ecological, or morphological response to rapid temperature change. I anticipate a decrease in taxonomic diversity and shell volume and an increased abundance of low activity-level species, similar to the ecological impacts observed in response to Large Igneous Province eruptions in the geologic record. Clumped isotope paleotemperature reconstruction recovers …

The Moderating Role Of Meaningful Work On The Relationship Between Loss Of Self-Identity And Psychological Well-Being In Retired Collegiate Athletes, Sarah M. Kurd

Master's Theses

Collegiate athletes are a focal point for many universities. These student-athletes work most of their lives to make it to the university level. Many collegiate athletes aspire to make it to the professional level after they graduate from college, but only a rare handful make it to the top. The rest of the athlete population retires and is placed into a world of “normalcy,” but the transition out of athletics can be very challenging, impacting a person’s psychological well-being. Most of these athletes will have to work a professional job after leaving sports. The present study aimed to examine the …

A Novel Reinforcement Learning Method For Efficient Cross-Training Between Real And Simulated Robots, Zhonglin Liang

Master's Theses

Training reinforcement learning policy in a simulated environment can be a go-to choice for many research topics, as a simulated environment provides flexibility and costs less than building a physical environment for training. However, policy trained in a simulated environment often fails to transfer to the real environment for problems that have a more complex dynamics. As the solution, Sim2Real was proposed and it categorizes techniques that improve the performance of the transfer from simulation to reality. Sim2Real is an area of study that focuses on utilizing simulation data to train models that can apply to real world environment. It …

Internet Of Medical Things: Integrating Machine Learning And Wearables For Healthcare, Jingwen Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

The Internet of Medical Things (IoMT), which integrates Internet of Things technologies into healthcare, has become a powerful tool for enhancing health monitoring and predicting clinical outcomes. By leveraging wearable devices, IoMT facilitates continuous, cost-effective, and convenient tracking of patients' health conditions over time. This dissertation applies data-driven methods to address critical clinical challenges involving wearable devices. Specifically, it focuses on three significant clinical problems: (1) indoor contact tracing for healthcare workers using Bluetooth Low Energy (BLE) beacons, (2) predicting surgical outcomes using wearable data, and (3) developing robust models for surgical outcome prediction that account for patient variability using …

Internet Of Medical Things: Integrating Machine Learning And Wearables For Healthcare, Jingwen Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

The Internet of Medical Things (IoMT), which integrates Internet of Things technologies into healthcare, has become a powerful tool for enhancing health monitoring and predicting clinical outcomes. By leveraging wearable devices, IoMT facilitates continuous, cost-effective, and convenient tracking of patients' health conditions over time. This dissertation applies data-driven methods to address critical clinical challenges involving wearable devices. Specifically, it focuses on three significant clinical problems: (1) indoor contact tracing for healthcare workers using Bluetooth Low Energy (BLE) beacons, (2) predicting surgical outcomes using wearable data, and (3) developing robust models for surgical outcome prediction that account for patient variability using …

The Grizzly, November 14, 2024, Kate Horan, Connor Mccarney, Sidney Belleroche, Caitlin Cunnane, Sophia Kumar, Stella Bower, Emily Veasey, Mary Lauren Franz, Kylie Ruggiero

Ursinus College Grizzly Newspaper, 1978 to Present

"Keep Moving Forward" • Hora De Café • Bears on Trial • A Dorm Cat's Story • The Yap: A Recession of "Meet-Cute" Stories? • Bears' Zelinske Defies the Odds • Gymnastics Coach DeLorme Does It All

Flute Studio Recital: November 14, 2024, Dr. Kimberly Risinger, Gina Russell

School of Music Programs

Kemp Recital Hall

November 14, 2024

Thursday Morning

11:00 a.m.

Oboe Studio Recital: November 14, 2024, Illinois State University School Of Music

School of Music Programs

Kemp Recital Hall

November 14, 2024

Thursday Evening

7:30 p.m.

November 14, 2024, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Re: Butte Mine Flooding Site Cd, Cv 02-35 Bu-Rfc, 2024 Third Quarter Report, Mark Thompson, Dave Griffis

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Kenyon Collegian - November 14, 2024

The Kenyon Collegian

No abstract provided.

Sleep Architecture Changes In Diabetes., Yuanjie Mao

Ambulatory and Primary Care Articles

Data on the relationship between sleep architecture and diabetes are limited. However, some evidence suggests that slow-wave sleep (SWS) plays a crucial role in maintaining normal glucose homeostasis and influences insulin secretion capacity. Diabetes is often associated with reduced SWS, even in the absence of sleep-disordered breathing. Notably, selective suppression of SWS-without reducing total sleep time-can lead to significant increases in insulin resistance, decreased glucose tolerance, and a higher risk of diabetes. Given the growing interest in non-pharmacological lifestyle interventions, such as modifying sleep architecture, it is important to understand how sleep patterns differ in individuals with diabetes and whether …

Letter From The Editorial Board, Joshua M. Avery, Lana Wilson, Denise Nelson, Addison Lucchi

The Christian Librarian

No abstract provided.

Knowledge, Attitudes, And Concerns About Psilocybin And Mdma As Novel Therapies Among Us Healthcare Professionals, Erin Wang, David S Mathai, Natalie Gukasyan, Sandeep Nayak, Albert Garcia-Romeu

Center for Medical Ethics and Health Policy Staff Publications

Psychedelic-assisted therapy (PAT) with substances like psilocybin and MDMA has shown promise for conditions including depression and post-traumatic stress disorder. Psilocybin and MDMA may become approved medicines in the coming decade. This study assessed knowledge and attitudes regarding PAT among 879 U.S. healthcare professionals via anonymous online survey. Multivariable linear regression was used to identify predictors of openness to clinical use. Most participants (71.2%) were female and White (85.8%), with a mean (SD) age of 45.5 (12.7) years. Registered nurses (25.4%) and physicians (17.7%) comprised the largest professional groups. Respondents endorsed strong belief in therapeutic promise, and moderate openness to …

Improving Hand Hygiene Compliance Through Electronic Monitoring, Ruth Navarro, Lupe Almaguer, Andrea Tilleman, Ayesha Pacheco, Sebastian Zuluaga, Bianca De La Barra, Hector Vega

All Publications

No abstract provided.