Digital Commons Network^™

Music Perception And Speech Perception Have Different Sensitivities To Acoustic Variability, Kate Criner, Anya Shorey, Christian Stilp

The Cardinal Edge

Word recognition is faster and/or more accurate when listening to a single talker than to multiple talkers in random orders. Subsequent research revealed that perception is challenged more by different-sounding talkers (in terms of voice pitch) than similar-sounding talkers. This experiment tested the extension of these findings to musical instrument perception. Listeners completed six blocks: three blocks of word recognition (by one talker, four similar-sounding talkers [similar voice pitch], four different-sounding talkers [varying voice pitch]) and three blocks of pitch labeling (by one instrument, four similar-sounding musical instruments [wind instruments with similar attacks and spectra], four different-sounding musical instruments [differing …

The Psychological Effects Of Discriminations In Sexual And Gender Minority Individuals: A Qualitative Analysis, Kameryn S. Freeman, Konrad Bresin, Julia Nicholas

The Cardinal Edge

Sexual and gender minority (SGM) individuals experience minority stressors (e.g., rejection, discrimination, and victimization) that may negatively impact their mental health. This study used a mixed-methods approach to identify common themes across minority stress experiences and explore whether reflecting on these themes elicits changes in effect.

N = 25 undergraduate students with an SGM identity completed the study for course credit. Participants wrote about an instance of SGM discrimination that they experienced, witnessed, or heard about. Participants self-reported their positive and negative effects before and after writing. Participants’ stories were analyzed qualitatively to identify common themes. Correlations were calculated between …

The Impact Of Telepractice On Voice Production In Normal Hearing Children, Rachael Walsh, Yesenia Rodriguez Cruz, Maria Kondaurova

The Cardinal Edge

Telepractice is a growing service model that delivers aural rehabilitation services to deaf and hard of hearing children at a distance via telecommunications technology. Research suggests that when there is a physical barrier in communication there is an increase in vocal effort in children with and without hearing loss. The aim of the current study is to examine the effect of telepractice on voice production in normal-hearing (NH) children to enhance intervention effectiveness. Ten normal-hearing children (mean age = 10.4 years, age range 8-12 years) came to participate in four sessions, 2 in-person and 2 tele, order counterbalanced. Each session …

Investigating Pre-Health Students’ Science Identity And The Factors That Influence Them To Change Programs Or Tracks, Taylor Humphreys

The Cardinal Edge

Retention rates for undergraduate students in pre-health programs or tracks have had a continual decline as students progress through their bachelor’s degrees. While numerous articles publish statistics regarding students on a pre-med track with intentions to apply to medical school, information is not available for pre-health students applying to other health professional schools. It is important to know what measures can be taken or resources offered to improve the retention rates across these programs or tracks.

Peer-led focus groups were used to elicit uncensored responses from students. Focus groups allowed for a small number of participants with similar interests or …

How Medical Students Address Mental Health During Standardized Patient Interactions, Bhoomi S. Shah, Laura Weingartner, Emily J. Noonan

The Cardinal Edge

How Medical Students Address Mental Health during Standardized Patient Interactions

Bhoomi Shah B.S. Candidate; Emily J Noonan, PhD, MA; Laura A. Weingartner, PhD, MS

BACKGROUND:

As mental health needs are increasingly recognized around the world, it has become an increasingly important topic within medical education to ensure that medical professionals are well-prepared to address these concerns and provide adequate mental health care to patients. Our research examines the language that medical students used to assess and address mental health concerns during clinical skills training.

METHODS:

We observed standardized patient interactions with 85 medical students from the University of Louisville School …

Manipulation Of The Past, Andrew T. Heggie

The Cardinal Edge

In recent years this nation has been undergoing a public debate about its past. This debate ranges from academic projects such as the New York Times’s 1619 Project to the Florida Department of Education’s recent judgments regarding a new AP African American Studies Course. Through watching these debates, I was led to the following questions: What is the past? How or why can it be changed? And what is its relevance to politics and education? For This I turned to Augustine’s Confessions (1961) and post-war German Philosophy, specifically the works of Theodor Adorno and Hannah Arendt. For this project, Augustine’s …

The Effect Of Prenatal Vape Exposure On Liver Gene Expression In Weanling Mice, Mindy Yin, Selma Podbicanin, Bella Fieger, Nina Pauig, Katelyn Chism, Lucas Georges, Isaiah Burciaga, Cynthia Corbitt, Rachel Neal

The Cardinal Edge

The use of E-cigarettes is a fairly recent phenomenon. Vaping is thought of as the “healthier” alternative to smoking cigarettes, yet we know little about the developmental toxicity of commercially available vaping products. The Barker Hypothesis (or the Developmental Basis of Adult Disease Hypothesis) proposes that developmental nutrient restriction or toxicant exposure increases the risk of diseases later in life such as cardiovascular disease, fatty liver, and metabolic diseases. In this study, adult female C57Bl/6 mice were exposed to Vuse™ Alto Golden Tobacco pods (5% nicotine) 4 days before mating and throughout gestation (GD19) for 1 hour/day each day. Offspring …

Avaren-Fc, A Novel Immunotherapeutic, Recruits Nk Cells In B16f10 Melanoma Tumor Tissue, Sreevatsa Vemuri, Katarina L Mayer, Nobuyuki Matoba

The Cardinal Edge

Melanoma is the fifth most common cancer in the US, with limited effective immunotherapeutic options available for patients. Avaren-Fc (AvFc) is a novel experimental immunotherapeutic agent with a unique “lectibody” property. It is capable of targeting cancer cells through the selective recognition of high mannose glycans, which are aberrantly overrepresented on the surface of malignant cells. Upon binding to cancer cells, AvFc can interact with circulating effector immune cells equipped with Fc receptors, such as natural killer (NK) cells to induce antibody-dependent cell-mediated cytotoxicity (ADCC) and kill the cancer cells. Previous work has shown that AvFc effectively induces ADCC activity …

Cellular Senescence In Peripheral Tissues After Spinal Cord Injury, Tanisha A. Valdez, Benjamin R. Rood, Lukasz P. Slomnicki, Yonglin Gao, Mason Miller, Kariena Andres, Scott R. Whittemore, Michal Hetman

The Cardinal Edge

Cellular senescence is the phenomenon in which cells undergo permanent cell cycle arrest and is caused by natural aging or pathological mechanisms. Depending on the physiological context, pathological senescence can potentially be implicated in chronic inflammation but may also have a role in promoting tissue repair. Spinal cord injury (SCI) is a whole-body injury, in which patients with SCI often experience complications in organ systems outside of the CNS. Our recent data has shown that senescence can develop in the spinal cord after SCI but the extent that senescence contributes to dysfunctions of peripheral tissues remains unclear. This study sought …

Utilization Of An Alternative Responder Model To Address Behavioral Health Care Related Calls To 911 In Louisville, Kentucky, Jacelyn Grimes, Paige Roberson, Mads Priddy, Brian Schaefer

The Cardinal Edge

In March 2022, Louisville Metro launched the Crisis Call Diversion Program (CCDP) which is redefining how the city responds to 911 behavioral health emergencies. The CCDP is an alternative responder model that works to deflect 911 calls from law enforcement and provide the individual in crisis with “someone to talk to,” “someone to respond,” and “a place to go.” The UofL School of Public Health and Information Sciences was contracted to evaluate the intervention and in this poster, we will describe how the CCDP works, the evaluation design, and outcomes in the first year of operations.

The Role Of Adhd As A Risk Factor In Alzheimer's Disease, Evelyn Fulmer

The Cardinal Edge

In recent years, the prevalence of attention-deficit/hyperactivity disorder (ADHD) and Alzheimer’s disease (AD) has increased significantly. While these disorders initially seem unrelated, ADHD and AD pose similarities that indicate a more involved relationship between them. To understand this relationship, this review delves into the current research proposing ADHD as a potential risk factor in the development of Alzheimer's disease, examining genetic predispositions, shared risk factors, and affected mechanistic pathways that influence the aging process.

The Relationship Between Protein Synthesis And Aging, Christopher A. Jackel

The Cardinal Edge

Aging is a complex process influenced by various cellular mechanisms, with several distinctive features associated with its progression. Among the hallmarks of aging is the loss of proteostasis, or disruption in the balance of proteins within the cell. Recent research has made significant strides in unraveling the intricate relationship between proteostasis and aging. Notably, studies have demonstrated that decreased protein synthesis can extend the healthspan of organisms. Moreover, inhibition of mechanistic target of rapamycin (mTOR) complex 1 has been shown to selectively reduce the lifespan limiting proteins while promoting autophagy, thereby extending organismal lifespan. Thus, this paper aims to review …

The Impact Of Chronic Stress On The Aging Process, Toriana Alfieri

The Cardinal Edge

Chronic stress can be characterized as a prolonged stressor that negatively impacts one’s life and has been associated with a variety of adverse health outcomes, including cardiovascular disease and immune system suppression. Given that chronic stress undeniably impacts health as a whole, it is reasonable to assume that it may also affect the aging process. The purpose of this literature review is to investigate the impact of chronic stress on the aging process with a specific focus on the 12 hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, …

Anti-Aging Properties Of Cosmetics, Anna Lipinski

The Cardinal Edge

It is well established that external factors, specifically UV exposure, are among the highest contributors to the biological aging of the skin. Prolonged exposure may disrupt skin cell homeostasis through shifts in proteostasis, accumulation of reactive oxidative species, premature cellular senescence, and inflammatory pathways. Cosmetic companies have responded to this by producing products marketed as "youthful" and "anti-aging" by including specific compounds into formulas to combat skin aging. This review discusses the specific mechanisms of anti-aging formulas, including polyphenols as senotherapeutic agents and L-ascorbic acid as an anti-inflammatory compound, in resisting the biological aging of the skin.

A Hopeful Overview On Aging, Rafael Demarco

The Cardinal Edge

N/A

Good Grief!: The Challenging Of Middle-Class Life By Youth Culture In Mafalda And Peanuts, Eden E. Baize

The Cardinal Edge

The politically and socially tumultuous world of the mid-20th century in both Argentina and the United States inspired the creation of two incredibly influential comic strips: Joaquín Salvador Lavado’s, also known as Quino’s, Mafalda in Argentina, and Charles Schultz’s Peanuts in the United States. These comics changed the popular conception of childhood in their respective countries by reflecting the cultural shifts which challenged existing social conventions like family organization. Primarily, however, the central theme of these works rested in the commentary on the growing middle-class and the role of younger generations in championing countercultural and antiestablishment movements against this expansion. …

An Analysis Of The Environmental Account Of Obesity As A Form Of Financial Neo-Imperialism, Zahara Alzubaidi

The Cardinal Edge

Socioeconomic developments of the past half-century have created mass social concern over an “obesity epidemic.” This concern is given a sense of legitimacy by studies that warn of a totally obese America in only a few decades, and children being more likely than ever to be diagnosed with Type 2 Diabetes. The “environmentalist account” of obesity asserts that factors like genetics, food availability, and social or political climate are the major determinants of an “obesogenic environment” – that is, an environment of obese adults likely to raise obese children. Some feminist thinkers argue that the environmentalist account is necessary to …

Sdf-1Α Mediates Primary Tumor Escape In Glioblastoma Through Activation Of Mesenchymal Transitions, Charles T. Froman-Glover

The Cardinal Edge

Glioblastoma (GBM), a highly aggressive primary brain tumor originating in glial cells, poses a significant challenge due to its rapid growth and invasive nature within healthy brain tissue.

Current treatments involve surgical resection, chemotherapy, and radiation. These treatments alone are not enough to cure this disease, and a better understanding of the mechanics of the tumor's micro-environment is imperative to furthering the field of cancer research. This research focuses on understanding the tumor microenvironment's impact, specifically investigating the role of stromal cell-derived factor 1 (SDF-1) mechanics on GBM aggressiveness. SDF-1 is known to facilitate disease progression by facilitating chemotaxis toward …

Autoimmunity And The Epigenome, Jeffrey S. Miller Jr

The Cardinal Edge

No abstract provided.

Resilience And Evolution: The Transformative Impact Of The Black Death On Women’S Roles In Medieval England, Kaylee N. Vitato

The Cardinal Edge

"Resilience and Evolution: The Transformative Impact of the Black Death on Women’s Roles in Medieval England" delves into the nuanced effects of the Black Death on gender dynamics in medieval England. While there were positive shifts in attitudes toward women's roles, persistent challenges, such as unequal employment conditions, lower wages compared to men, and negative household stereotypes, endured. The research examines alterations in labor markets, inheritance norms, property laws, and domestic dynamics to uncover the multifaceted impact of the Black Death on the evolution of women's roles. Despite emerging opportunities for women in previously male-dominated spheres, the analysis also reveals …

Disease And Discrimination: The Persecution Of Jews In The Holy Roman Empire During The Black Death, Abigail M Stanger

The Cardinal Edge

The Black Death, the second major plague pandemic caused by the spread of the bacteria Yersinia pestis, emerged in the Holy Roman Empire in 1348. Throughout its spread until 1352, the plague devastated residents of the Holy Roman Empire regardless of demographic features. However, Christians at the time believed that members of Jewish communities died at significantly lower rates than themselves, and already existing sentiments of antisemitism grew into the assignment of blame onto Jews. This concurrent spread of plague and antisemitism resulted in pogroms and other forms of mass violence against Jewish communities across Europe, but specifically in the …

Cultural And Personal Inheritance: Generational Trauma In Madeline Miller's Circe, Emily Stucky

The Cardinal Edge

Madeline Miller’s Circe, Miller considers varying perspectives on a well-known character—one who has been vilified as a monster, recast as a feminist icon, and rewritten into a variety of spaces in between. As part of this continuous narrative, Miller draws on the inherently hybrid space of Circe’s character to construct her as a product of her multi-faceted lineage. A character with so many identities makes for a complicated subject, but Miller utilizes this plurality to her advantage, deliberately casting Circe as a product of multiple backgrounds—occupying both the space of oppressor and oppressed—to both compound her status as a …

Can Men Be Feminists?, Abigail M Stanger

The Cardinal Edge

At the emergence of the feminist movements of the mid-nineteenth century, women advocated for and eventually gained the right to make their voices heard in the political arena. As feminism has evolved to campaign for social, economic, and further political equality among genders, the question of who can be a feminist remains a topic of debate. This presentation will first attempt to define feminism historically and in the modern sense, then ponder the evolving definition of a man in relation to their potential role or lack thereof in the modern feminist movement.

Mechanical Circulatory Support For Pediatric Patients: An Interdisciplinary Approach, Amani Ikram

The Cardinal Edge

No abstract provided.

Louisville’S Roots In Pollution: A Battle Against Environmental Injustice, Harshith Gontla, Sireen Khader, Rianna Pais, Swetha S. Nathan

The Cardinal Edge

No abstract provided.

The Louisville Housing Crisis, Rebecca Klukowski

The Cardinal Edge

There is no question of whether the United States is facing a housing crisis. With approximately 653,104 Americans experiencing homelessness on a given night in 2023 and 22.4 million renter households cost-burdened in 2022, the facts speak for themselves (de Sousa et al., 2023; Joint Center for Housing Studies, 2024). However, understanding the complex contributing factors to a housing crisis can be difficult. What does it mean for housing to be affordable? How is our state of Kentucky affected by housing insecurity, and what can the general public do to help?

Cambodian American Parents Perspectives And Knowledge Of Special Education Supports For Their Children With Disabilities, Robai N. Werunga, Minjeong Kim, Rocio Rosales

Journal of Southeast Asian American Education and Advancement

Knowledge of the special education process has been found to enhance parental involvement with collateral effects of positive school outcomes for students with disabilities. Although research on immigrant families with children with disabilities has increased in recent years, there is limited research specific to Southeast Asian American (SEAA) families, and that of Cambodian American families, in particular. In this study authors examined the perspectives and knowledge of Cambodian American parents regarding disabilities, special education services and supports provided to their children with disabilities, and the extent to which these perspectives and their knowledge impacted their level of engagement in their …

International Student Discussion Panel, Ray Sanders, College Of Business

International Education Week

Join us for a compelling panel discussion hosted by Professor Ray Sanders, featuring current international students sharing their unique experiences of coming to the United States. Hear fascinating stories, gain insights into how American culture is perceived from different cultural perspectives, and broaden your understanding of the world. This is a wonderful opportunity to learn, connect, and expand your horizons. 🌐🎓

Vol. 9, No. 6, Glen Goodknight

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 9, No. 5, Glen Goodknight

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.