Digital Commons Network^™

New Formulation Of Devitalize Paste Containing Pulp Out For Tooth Application, Maria Tanumihardja, Ermina Pakki, Fredryk Mandey, Lukman Muslimin

Journal of Dentomaxillofacial Science

Pulp Out, a combination of root extract of sidaguri (Sida rhombifolia), the sap of jatropha (Jatropha curcas), and melittin, have been proven by in vivo study as a tooth-pulp devitalizing agent which has similar properties to arsenic, but has limited side effects. Pulp Out needs to be formulated in a stable dosage form to optimize the application. The goal of the present study was to produce a stable paste-containing Pulp Out using sodium carboxymethylcellulose (Na CMC, 1.25 (F1), 2.5 (F2), 5.0 (F3)) and hydroxypropyl methylcellulose (HPMC, 1.25 (F4), 2.5 (F5), 5.0 (F6)). The effectiveness of the …

Gingival Recession Caused By Aberrant Frenum Traction: A Case Report, Muhammad Haritza, Alfrida Pasangalo, Mardiana A. Adam, Sri Oktawati

Journal of Dentomaxillofacial Science

Introduction: An aberrant frenum can cause a misplaced traction on the gingival margin resulting in a gingival recession. This recession can cause problems on Conservative and Aesthetic treatment due to periodontal trauma caused by such treatment. This case report seeks to outline such case and how it hampers a conservative treatment. Case: A 25 year old female patient was referred the Periodontology Department of Hasanuddin Dental Hospital from the Conservation Department. The patient was indicated for a Dental Crown, however due to an aberrant frenum causing a gingival recession the patient was referred for a frenectomy. Case Management …

Evaluation Of Calcium, Fluoride, And Phosphate Ion Release Of Three Bioactive Resins In Ph-Cycling Solution, Dewi Puspitasari, Agung S. Wardhana, Indri I. Tari, Romadhona Setiyoly, Ariska, Sherli Diana, Muhammad Yi. Nahzi, Diana Wibowo, Yosi K. Eriwati, Priyawan Rachmadi

Journal of Dentomaxillofacial Science

Bioactive resin containing calcium, fluoride, and phosphate in the formulation may promote remineralization in email and dentin. This study aimed to evaluate the amount of calcium, fluoride, and phosphate ions released from composite resin, alkasite, and giomer when stored in a pH-cycling solution. Ninety specimens (diameter 15 mm & thickness 1 mm, n=5/group) were fabricated with bioactive composite resin (Activa), alkasite (Cention N), and giomer (Beautifil II). Half of the specimens were immersed in demineralizing solution of pH 4.4 and remineralizing solution of pH 7 alternating constantly for pH-cycling. In contrast, the other half of the specimens were immersed in …

Medical School Ranking And Provider Outpatient Medicare Part D Claims For Antibiotics Among Older Patients In The Usa, Mayar Al Mohajer, David Slusky, David Nix, Catia Nicodemo

Faculty, Staff and Students Publications

BACKGROUND: Our study aimed to assess whether there was a relationship between graduating from higher-ranked medical schools and the rate of prescribing antibiotics among Medicare Part D providers in the USA.

METHODS: The study obtained data from the Medicare Part D Prescribers (FY2013-2021) and the Doctor and Clinicians National repositories. A regression model was fitted to assess the relationship between provider medical school ranking and the rate of antibiotic days supplied per 100 beneficiaries at the provider level.

RESULTS: A total of 197 540 providers were included. No association was found between the medical school ranking and the rate of …

Characteristics Of High-Risk Bipolar Bone Loss Lesions Using 3-Dimensional Imaging, Petar Golijanin, Justin Arner, Claire Ryan, Qais Zai, Liam Peebles, Annalise Peebles, Phob Ganokroj, Ryan Whalen, Stephanie Eble, Danielle Rider, Srdjan Ninković, Matthew Provencher

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: The concept of on-track versus off-track bone lesions in glenohumeral instability continues to evolve. Although much has been ascertained from an original biomechanical model, bony pathological changes, especially on 3-dimensional (3D) imaging, have not been fully evaluated.

PURPOSE: To compare the differences in on-track versus off-track lesions to characterize glenoid and humeral head bone defects using 3D modeling software.

STUDY DESIGN: Cross-sectional study; Level of evidence, 3.

METHODS:A consecutive cohort of 75 patients with recurrent anterior instability, with evidence of Hill-Sachs lesions (HSLs) and
glenoid bone loss (GBL) and a mean age of 27.1 years (range, 18-48 years), were …

October / November / December 2024, Randy Curry, Cindy Brooks

RURAL ROCKS

This is the October - November - December issue of Rural Rocks from the SWOSU College of Pharmacy.

Bst2 Facilitates Activation Of Hematopoietic Stem Cells Through Erk Signaling, Marcus A Florez, Apoorva Thatavarty, Duy T Le, Holly A Hill, Youngjae Jeong, Brian M Ho, Pawel Kus, Trisha K Wathan, Bailee N Kain, Shixia Huang, Dongsu Park, Katherine Y King

Faculty, Staff and Students Publications

The proinflammatory cytokine interferon-gamma (IFNγ) is upregulated in a variety of infections and contributes to bone marrow failure through hematopoietic stem cell (HSC) activation and subsequent exhaustion. The cell surface protein, bone marrow stromal antigen 2 (BST2), is a key mediator of this process, as it is induced upon interferon stimulation and required for interferon-dependent HSC activation. To identify the mechanism by which BST2 promotes interferon-dependent HSC activation, we evaluated its role in niche localization, immune cell function, lipid raft formation, and intracellular signaling. Our studies indicated that knock out (KO) of BST2 in a murine model does not disrupt …

A Census Of Dwarf Galaxy Satellites Around Lmc-Mass Galaxy Ngc 2403, Jeffrey L. Carlin, David J. Sand, Burçin Mutlu-Pakdil, Denija Crnojević, Amandine Doliva-Dolinsky, Christopher T. Garling, Annika H.G. Peter, Jean P. Brodie, Duncan A. Forbes, Jonathan R. Hargis, Aaron J. Romanowsky, Kristine Spekkens, Jay Strader, Beth Willman

Faculty Research, Scholarly, and Creative Activity

We present the first comprehensive census of the satellite population around a Large Magellanic Cloud stellar-mass galaxy, as part of the Magellanic Analog Dwarf Companions and Stellar Halos (MADCASH) survey. We have surveyed NGC 2403 (D = 3.0 Mpc) with the Subaru/Hyper Suprime-Cam imager out to a projected radius of 90 kpc (with partial coverage extending out to ∼110 kpc, or ∼80% of the virial radius of NGC 2403), resolving stars in the uppermost ∼2.5 mag of its red giant branch. By looking for stellar overdensities in the red giant branch spatial density map, we identify 149 satellite candidates, of …

Beyond Boundaries: Governance Considerations For Climate-Driven Habitat Shifts Of Highly Migratory Marine Species Across Jurisdictions, Bianca S. Santos, Elliott L. Hazen, Heather Welch, Nerea Lezama-Ochoa, Barbara A. Block, Daniel P. Costa, Scott A. Shaffer, Larry B. Crowder

Faculty Research, Scholarly, and Creative Activity

The mobile nature of migratory marine animals across jurisdictional boundaries can challenge the management of biodiversity, particularly under global environmental change. While projections of climate-driven habitat change can reveal whether marine species are predicted to gain or lose habitat in the future, geopolitical boundaries and differing governance regimes may influence animals’ abilities to thrive in new areas. Broad geographic movements and diverse governance approaches elicit the need for strong international collaboration to holistically manage and conserve these shared migratory species. In this study, we use data from the Tagging of Pacific Predators program to demonstrate the feasibility of using climate-driven …

Comparison Of 45-Min Nap Versus No-Nap During Simulated Night Shift Work On Endothelial Function: A Randomized Crossover Feasibility Trial, P. Daniel Patterson, Cassie J. Hilditch, Sarah E. Martin, David G.L. Roach, Matthew D. Weaver, Tiffany S. Okerman, David Hostler, Leonard S. Weiss, Steven E. Reis

Faculty Research, Scholarly, and Creative Activity

Background: Night shift workers face increased risk of cardiovascular disease (CVD) compared to non-shift workers. Evidence supports on-shift napping and regular non-invasive monitoring of endothelial function for risk mitigation, yet neither strategy is widely used. Methods: We evaluated the feasibility of non-invasive assessment of peripheral arterial tone (PAT) to assess the effect of napping during simulated night shift work on endothelial function. We used a single-site, randomized crossover trial of simulated night shift work with a 45-min nap condition versus a control, no-nap condition (ClinicalTrials.gov NCT05436951). Results: The primary outcome was the number of participants with ≥ 70% of endothelial …

Piloting A Novel Computational Framework For Identifying Prosthesis-Specific Contributions To Gait Deviations, Jacques Ezechiel N'Guessan, Muhammad Hassaan Ahmed, Matthew Leineweber, Sachin Goyal

Faculty Research, Scholarly, and Creative Activity

This paper introduces a novel computational framework for evaluating above-knee prostheses, addressing a major challenge in gait deviation studies: distinguishing between prosthesis-specific and patient-specific contributions to gait deviations. This innovative approach utilizes three separate computational models to quantify the changes in gait dynamics necessary to achieve a set of ideal gait kinematics across different prosthesis designs. The pilot study presented here employs a simple two-dimensional swing-phase model to conceptually demonstrate how the outcomes of this three-model framework can assess the extent to which prosthesis design impacts a user's ability to replicate the dynamics of able-bodied gait. Furthermore, this framework offers …

Late Gadolinium Enhancement And Anomalous Coronary Aortic Origin In A Large Paediatric Cohort, Shagun Sachdeva, Lauren Ferrino, Tam T Doan, Dana Reaves-O'Neal, Stephen Dolgner, Alberto Cipriani, Cristina Basso, Massimo A Padalino, Domenico Corrado, Prakash Masand, Silvana Molossi

Faculty, Staff and Students Publications

No abstract provided.

The Role Of Porphyromonas Gingivalis In Inducing Il-6 Macrophages Expression In Ovaries Of Periodontitis Models, Agustin Ws. Dharmayanti, Ernie M. Setiawatie, Hendy Hendarto

Journal of Dentomaxillofacial Science

Objective: This study aimed to determine whether P. gingivalis induction in the gingival sulcus increased IL-6 expression by macrophages in the ovaries.

Material and Methods: This research was a laboratory experiment using a post-test-only control group design, using female white rats strain Sprague Dawley, six weeks old and in the estrous phase. They were divided into the control and treatment groups. The animal models were induced with P. gingivalis in the mesial gingival sulcus of their first right and left lower jaw molars, with 0.05 ml every three days for 19 days. On 0, 7, 14 days after bacteria induction, …

Relationship Between Risk Factors Of Dysphagia, Occlusal Tooth Contact And Oral Health-Related Quality Of Life In The Elderly, Muslita Indrasari, Lindawati S. Kusdhany, Randi Dias

Journal of Dentomaxillofacial Science

Objective: Tooth loss and changes in the swallowing mechanism in the aging process can lead to dysphagia. Individuals who are at risk of experiencing dysphagia have an impact on the health and quality of life and contribute to the cost of health care. The aim of this study to analyze the relationship between risk factors of dysphagia, occlusal tooth contact and oral health-related quality of life (OHRQoL) and find out which factors contribute the most to OHRQoL among the elderly.

Material and Methods: This cross-sectional study using consecutive sampling method from 121 respondents aged 60 years and over. The General …

Chitosan Black Soldier Fly (Hermetia Illucens) Pupae Can Improve Macrophages And Fibroblast Post-Extraction Teeth, Renie K. Dewi, Sri Oktawati, Asdar Gani, Eko Suhartono, Zakiah H. Noor, Nurlindah Hamrun, Shahida M. Said, Beta W. Oktiani

Journal of Dentomaxillofacial Science

Objective. The objective of this study was to quantify the number of macrophages and fibroblasts involved in the post dental extraction socket healing.

Material and Methods. Chitosan BSF pupae was made into a gel preparation. Eighteen Male Cavia cobaya were divided into two groups (n = 9), control and treatment groups. BSF pupae chitosan gel was applied to the post-extraction tooth socket in the treatment group, while none was applied to the control group. The samples were decapitated on the 2^nd, 3^rd, and 5^th days by cutting the mandibular bone for histopathological examination, which was …

Dlsu Monthly Report Of The Philippine Economy (December 2024 Report), Neriza Chow, Jesus Felipe, Mariel Monica Sauler

Angelo King Institute for Economic and Business Studies (AKI)

No abstract provided.

December 2024: Region 10 Emerging Special Pathogen Treatment Center (Resptc) At Providence Sacred Heart Medical Center & Children’S Hospital, Providence - Special Pathogens Program

Special Pathogens Newsletters

REGION 10 SPECIAL PATHOGENS NEWSLETTER

'Buy Me Some Peanuts And Cracker Jacks': How Peanuts, Chewing Gum, Hot Dogs, And Beer Became Icons Of Americana Through Baseball, Miles Houman Cipriano

Graduate Masters Theses

BUY ME SOME PEANUTS AND CRACKER JACKS’: HOW PEANUTS, CHEWING GUM, HOT DOGS, AND BEER BECAME ICONS OF AMERICANA THROUGH BASEBALL December 2024 Miles Houman Cipriano B.A., Westfield State University M.A., University of Massachusetts Boston Directed by Professor Bonnie Miller Peanuts, chewing gum, hot dogs, and beer are often closely associated with the game of baseball. Beginning in the mid to late nineteenth century, baseball was a rising form of entertainment in the United States of America, and part of the spectator experience was the purchase of concessions. The business of concessions in America has grown into a multi-billion-dollar industry …

Evaluation Of 3d Beach Profiles: A New Method For Monitoring Changes In Beach Morphology And Grain Size, Kalinda Ellen Roberts

Graduate Masters Theses

Beach profiles are a simple and affordable approach to monitoring changes in beach morphology. However, traditional methods offer limited resolution and dimension. Recent advancements in technologies, particularly structure-from-motion (SfM) and grain size detection models (GSDMs), can be integrated into conventional beach profiling techniques, enabling more detailed spatial and temporal analysis of slope and grain sizes. This research introduces a new technique for coastal monitoring, termed “3D Beach Profiles,” which integrates SfM technology to create high-resolution three-dimensional digital surface models (DSMs) and orthomosaics of beach surfaces. These digital surfaces enable the extraction of beach slopes with orders of magnitude more data …

Frequency Distribution Of Graphemic-Phonemic Correspondences Of Vowels In English Children's Literature, Steven Michael Paquin

Graduate Masters Theses

Phonics instruction is widely regarded as the most efficacious method for teaching children to read English. In order to acquire reading, young-learners must connect orthography to phonology. An obstacle to English reading acquisition is the language’s opaque orthography. Its grapheme to phoneme correspondence is not 1:1. Instead, a range of multi-letter strings, or graphotactics, correspond to various phonemic sequences. This network of graphophonemic correspondences renders English reading acquisition an arduous undertaking for young-learners. Phonics curricula like Letters and Sounds (Department for Education and Skills, 2007) in the U.K. and UFLI Foundations (Lane et. al., 2022) in the U.S. aid young-learners …

The Provision Of Healthcare For Older Adults In A Massachusetts Jail/House Of Correction: Perspectives From Providers, Laura Driscoll

Graduate Doctoral Dissertations

THE PROVISION OF HEALTHCARE FOR OLDER ADULTS IN A MASSACHUSETTS JAIL/HOUSE OF CORRECTION: PERSPECTIVES FROM PROVIDERS November 2024 Laura C. Driscoll, B.S., Boston University M.S.P.T., Boston University DPT, MGH Institute of Health Professions M.S., University of Massachusetts Boston Ph.D., University of Massachusetts Boston Directed by Professor Jan Mutchler The aging population in U.S. jails is growing rapidly presenting significant challenges for healthcare provision within carceral settings. Older adults in these facilities often experience complex health conditions, including chronic diseases and age-related impairments, that require specialized care. Despite this, limited research has explored the experiences of healthcare providers tasked with caring …

Introducing A Practitioner's Framework For Mobilizing Collective Action, Matthew Paul Bond

Graduate Doctoral Dissertations

INTRODUCING A PRACTITIONER’S FRAMEWORK FOR MOBILIZING COLLECTIVE ACTION December, 2024 Matthew P. Bond, B.A. University of North Carolina Greensboro, M.S., University of Massachusetts Boston, M.P.A., Suffolk University, Ph.D., University of Massachusetts Boston Directed by Christian Weller Social dilemmas are situations in which individual and collective incentives are at odds, leading to suboptimal collective outcomes that make all individuals worse off. Modeling policy problems stuck in stasis as social dilemmas reveals new solution pathways that promise progressive change. The solution to a social dilemma is collective action, yet since the introduction of the collective action problem in the 1960’s, a solution …

Size Matters: The Characterization Of Telomere Function In Germ Cell Development In Danio Rerio, Jessica Macneil

Graduate Doctoral Dissertations

Infertility is a growing problem worldwide. According to the WHO, 48 million couples across the globe suffer from infertility and many couples turn to Assisted Reproductive Technology (ART) to become pregnant. One readout of gamete quality and successful ART is telomere integrity because telomeres are necessary for chromosome movements during meiosis so that the segregation of chromosomes happens correctly. Telomeres are well known for their role in aging; however, they play an important and understudied role during meiosis. In meiosis, telomeres attach to the nuclear envelope (NE) via a protein chain spanning the NE that interacts with cytoplasmic motor proteins, …

Democratizing The Early Identification Of Alzheimer's Disease And Access To Care: The Role Of Psychologists In Brief Assessment, Jacqueline S. Hogan

Graduate Doctoral Dissertations

As Alzheimer’s disease (AD) presents a growing public health challenge, accessible early detection tools are urgently needed. This study used data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (N = 1,536) to evaluate the ability of machine learning models to predict a conversion from normal cognition or mild cognitive impairment (MCI) to AD. A brief neuropsychological battery, including the Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS13), Mini-Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), and Functional Activities Questionnaire (FAQ), was employed. The Gradient Boosted Trees model demonstrated superior performance, achieving an F1 score of 0.88, recall of 0.93, precision …

The Application Of High-Resolution Mass Spectrometry For The Analysis Of Biopolymers, Metabolites, And Biologically Relevant Small Molecules, Christ Duc Tran

Graduate Doctoral Dissertations

High-resolution mass spectrometry (HRMS), as its name suggests, possesses high resolving power that enables the separation of ions with very close mass values. This is particularly beneficial for analyzing complex samples where numerous compounds may have similar masses, as it helps prevent signal overlaps and ensures an accurate spectral analysis. The current work explores the diverse applications of high-resolution mass spectrometry in oligonucleotide research, organic synthesis and medicinal chemistry. Oligonucleotide research: Chapters 2-5 present the research results from studies that employed ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS) to understand the pharmacokinetics of RNA interference (RNAi) therapeutics. The …

Removing Methane Via Soil Amendments: The Legal Framework, Korey Silverman-Roati, Romany M. Webb

Sabin Center for Climate Change Law

Rapid and sustained reductions in human-driven methane emissions are critical to limiting warming in line with the 2015 Paris Agreement. Reductions in certain methane emissions, particularly from the fossil fuel sector, can be implemented cheaply and efficiently. Other forms of methane emissions, like those from agricultural sources, are more difficult to control. This fact, coupled with concerns that climate change could unlock significant additional natural emissions from tropical wetlands and melting permafrost, has increased interest in atmospheric methane removal (“AMR”).

AMR refers to human interventions to accelerate the conversion of methane in the atmosphere to a form that causes less …

State Authority To Regulate Ocean Alkalinity Enhancement, Ashwin Murthy, Korey Silverman-Roati, Romany M. Webb

Sabin Center for Climate Change Law

This paper provides a detailed examination of the regulatory landscape surrounding Ocean Alkalinity Enhancement (“OAE”), a form of marine carbon dioxide removal (“CDR”) that seeks to mitigate climate change. The paper explores the domestic (U.S.) regulation of two of the most commonly discussed approaches to OAE: a mineral based approach and an electrolytic approach.

While no federal laws specifically mention OAE, the practice might be subject to various pollution control and other federal statutes and regulations. One key question is the extent to which federal law preempts state regulation of OAE. This paper aims to answer that question by reviewing …

Caed Shop Entrance Wall Redesign, Theodore Haoran Khuong, Joelle Schalesky, Ellen Elizabeth Untalan, Katherine Evalyn Timbes

Construction Management

This paper details the preconstruction process involving the replacement and redesign of the north wall at the CAED Support Shop at Cal Poly, San Luis Obispo. Accomplished by an interdisciplinary team of Architectural Engineering and Construction Management students, this project explores the requirements and procedures of generating a project proposal to submit to Cal Poly Facilities Management. The project, initiated in the fall of 2024, aimed to redesign the wall aligned with the adjacent Engineering West building and replace it with a CMU low lift grouted wall. The CAED Support Shop is offered as a resource to all CAED students …

Reducing Dna Extraction Costs Through Factorial Design For The Dnadvance Kit, Carson J. Neal, Zachery D. Zbinden, Michael E. Douglas, Marlis R. Douglas

Biological Sciences Faculty Publications and Presentations

Objective

Extracting DNA is essential in wildlife genetic studies, and numerous methods are available. However, the process is costly and time-consuming for non-model organisms, including most wildlife species. Therefore, we optimized a cost-efficient protocol to extract DNA from the muscle tissue of White-tailed Deer using the DNAdvance kit (Beckman Coulter), a magnetic-bead-based approach. We devised a 3 × 3 factorial design using combinations of tissue mass (10 mg, 50 mg, or 100 mg) and reaction volume (25%, 33%, and 50% of the manufacturer's recommended volumes). DNA was extracted for N = 81 tissue sub-samples (9 replicates/treatment).

Results

Our target yield …

Gc-Ms Analysis And Evaluation Of Antioxidant, Anticancer, Cytotoxicity, And Hypoglycemic Properties Of The Libyan Moringa Oleifera Leaf Extract On Alloxan-Induced Diabetes In Mice, Osama Abdel-Hafeez Mohammed Al-Bedak, Ahlam Rashed, Seham T.M. Oskandali, Nouri Kushlaf, Amal Eishebani, Samira A. Alacrouk, Fadia T.M. Oshkandale, Manal Eisheli, Zahur R. Almesai, Ameerah Shaeroun, Steven L. Stephenson, Fuad Ameen

Biological Sciences Faculty Publications and Presentations

Libyan Moringa oleifera leaves were extracted using methanol, and the bioactive components' antibacterial, antioxidant, anti-inflammatory, and anticancer characteristics were assessed using gas chromatography mass spectrometry analysis (GC-MS). Moringa oleifera exhibited antioxidant activity, with an IC50 of 11.53 µg/mL. Wi38 cell line's viability decreased with increasing M. oleifera extract concentration, while its cytotoxicity increased with an IC50 of 393.41±7.77 μg/mL. Alloxan-induced diabetes model in Swiss albino mice was implemented. Three different doses (100, 200, or 300 mg/kg of mice body weight) of M. oleifera’s extract were evaluated for their effects on blood sugar concentration and the histology of the pancreatic islets. …