Digital Commons Network^™

Spatial Insight Of Kidney Sex-Dimorphism And Tumor Evolution, Chia-Kuei Mo

McKelvey School of Engineering Graduate Student Theses & Dissertations

The landscape of spatial biology research has transformed drastically in recent years allowing a comprehensive understanding of cellular organization and molecular mechanisms in various biological context. This thesis presents three complementary studies that advance our understanding of spatial organization in normal tissue biology and tumor evolution, utilizing cutting-edge spatial multi-omics approaches. The first study presents a comprehensive investigation of kidney sexual dimorphism across the lifespan, integrating six distinct technological platforms: single-nucleus transcriptomics, epigenomics, Visium spatial transcriptomics, Xenium single-cell resolution spatial transcriptomics, conventional immunofluorescence imaging, and co-detection by indexing (CODEX) multiplexed protein imaging. This multi-modal approach reveals that proximal tubules exhibit …

Discrete Element Method For Mining Industrial Applications: Solving The Clumping Problem Caused By Bulk Cohesive Particles In An Iron Ore Beneficiation Process, Shuang Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

The discrete element method (DEM) is a widely used numerical approach for simulating and analyzing the behavior of granular materials in various applications. This research focuses on the iron ore beneficiation process, addressing the clumping issue in cohesive iron ores from existing crushing processes through a novel double-layered disperser design. The significance of this study lies in its potential to enhance the efficiency of the existing crushing phase and improve the linkage to subsequent purification stages that target smaller-sized iron ore pellets, thereby enhancing the overall efficiency of the ore beneficiation process and achieving significant energy savings. This research adopts …

Pan-Cancer Analysis Of Rna Dysregulation, Somatic Mutations, And Matrix Stiffness Using Bioinformatics Approaches, Gongyu Tang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cancer is a complex disease driven by genetic mutations, epigenetic modifications, and alterations in the tumor microenvironment. Understanding these intricate molecular mechanisms is crucial for advancing cancer diagnosis, prognosis, and treatment. RNA sequencing (RNA-seq) has emerged as a powerful tool to study cancer by providing comprehensive insights into gene expression, alternative splicing, and mutations at the transcriptome level. This dissertation leverages RNA-seq data to explore different dimensions of cancer biology through multi-omics integration and computational approaches. The research is divided into three main projects. First, I developed OncoDB, an interactive database to analyze gene expression, methylation patterns, and viral interactions …

Discrete Element Method For Mining Industrial Applications: Solving The Clumping Problem Caused By Bulk Cohesive Particles In An Iron Ore Beneficiation Process, Shuang Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

The discrete element method (DEM) is a widely used numerical approach for simulating and analyzing the behavior of granular materials in various applications. This research focuses on the iron ore beneficiation process, addressing the clumping issue in cohesive iron ores from existing crushing processes through a novel double-layered disperser design. The significance of this study lies in its potential to enhance the efficiency of the existing crushing phase and improve the linkage to subsequent purification stages that target smaller-sized iron ore pellets, thereby enhancing the overall efficiency of the ore beneficiation process and achieving significant energy savings. This research adopts …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Unreclaimed Sites And Insufficiently Reclaimed Areas – Racetrack Borrow Material Usage (Dated December 19, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

November 2024 Berkeley Pit Migratory Waterfowl Protection Monthly Report, Mark Thompson, Loren Burmeister

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Importance Of Social Support During Pregnancy For Girls With Limited Education, Mairo V. Bello

Walden Dissertations and Doctoral Studies

Social support signifies a system that provides for family, relatives, and friends or is derived from external sources such as social services or health promotion networks and can reduce depression and increase well-being. Absent from the literature was the understanding of the significance of social support for young women with limited education aged 18-25 on the journey from conception to the postpartum period in Nigeria. In this qualitative phenomenological study, the individual perception, attitude, and social support received by young women with limited education during pregnancy in Wudil LGA of Kano state in northern Nigeria were examined. The study addressed …

The Search For Unenumerated Fundamental Rights, Alina Sluzhyvenkova

Student Theses and Dissertations

There are certain rights that are explicitly enumerated in the Constitution, e.g., right to bear arms, right to free speech, right to a speedy and public trial. There are also rights that aren’t specifically written out but are nevertheless enjoyed by people nationwide. Rights that aren’t explicitly mentioned in the Constitution, but which are fundamental to are called the unenumerated rights. Unenumerated rights are just as important and can be derived from natural law, enumerated rights, the Ninth Amendment, precedents, judicial opinions, and substantive due process.

Substantive due process is a principle guaranteed by the Fifth and Fourteenth Amendments, which …

“Baking Inclusion Into Everything”: Internal Communication And Black And Latina Women’S Stories Of Intersectionality, Natalie Martell-Concepcion

Student Theses and Dissertations

Internal communications play a major role in creating diverse and inclusive workplace cultures. This study explores the lived experiences of Black and Latina women who work in internal communications, offering unique insights into how their identities intersect with workplace culture and strategic communication. Through a qualitative approach, six intersectional women, three Black and three Latina, were interviewed to examine how gender, racial and ethnic identities influence their work experiences and contributions. The results indicate that while Black and Latina women are treated differently at work compared to other groups, they use their differences to positively contribute to their companies’ internal …

Characterization Of Tfiie-Regulated Genes By Transcriptome Analysis, Serdar Baysal

Turkish Journal of Biology

RETRACTED: This article has been retracted. Please see the Retraction Notice for details. An Expression of Concern was previously published.

Previous studies on GTF2E showed that it has association with certain group of diseases such as colon cancer and trichothiodystrophy but what is the global effect of GTF2E on cellular processes is not widely characterized. In this regard, this study aimed to investigate and characterize the affect of GTF2E on transcription level of genes and identify the cellular processes and diseases associated with GTF2E. The HCT116 cell line was used in the study and transfected at 30 nM concentration with …

Develop New Quality Science-Communicative Forces To Support New Quality Productive Forces, Jiarui Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The importance of science communication has been elevated to an unprecedented height in China, as an important part of the national innovation system, and as important as scientific and technological innovation. Scientific and technological innovation is the core driving force for the development of new quality productive forces, and it is obvious that science communication plays an equally important role in promoting the development of new quality productive forces. This kind of role of science communication is named as new quality science-communication forces, which is mainly reflected in four aspects: creating an ecological environment conducive to innovation; advancing cutting-edge new …

On Relationship Between Experiment And Theory In Basic Scientific Research, Changpu Sun

Bulletin of Chinese Academy of Sciences (Chinese Version)

Understanding how experiments in basic scientific research “confirm” theories is crucial for upholding the spirit of science and fostering technological innovation. Mr. Zhou Guangzhao conducted an in-depth discussion on this topic in his early work. This study further analyzes the issue from the perspective of the philosophy of science. We derive falsificationism from a Bayesian perspective, providing a philosophical understanding of the proper handling of the relationship between scientific theory and experiment. By examining the relationship between theory and experiment in physics, this study proposes a philosophy of science concept of progressive falsifiability, emphasizing that through Bayesian methods, experiments can …

Action Logic And Agenda Game Of Global Methane Emission Control And China’S Countermeasures, Bo Zhang, Jinling Guo, Bing Zhong, Junlian Gao, Guosheng Zhang, He Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Originated from the global response to climate change, methane emission control has evolved into a focus of international climate negotiations in recent years. At present, the agenda for controlling methane emission in global climate governance is basically taking shape, but in the process of shifting from scientific consensus to political consensus, the content of the topic and the focus of the game continue to evolve. To carry out global action, it is necessary to address issues such as the allocation of responsibilities, international rules, climate investment and financing, and risk prevention, as well as the basic capacity guarantees behind them. …

Architecture And Key Technologies Of New Research Informatization Infrastructure Platform Under The Fifth Research Paradigm, Fangyu Liao, Yang Wang, Rongqiang Cao, Bo Zhang, Zhenyu Li, Huajin Wang, Xin Chen, Dong Li, Yangang Wang, Xin Wei

Bulletin of Chinese Academy of Sciences (Chinese Version)

The basic platform of research informatization is an indispensable pedestal for modern scientific research and an important manifestation of national scientific and technological innovation capability. As the research paradigm continues to evolve, the architecture and technologies of research informatization infrastructure platform are bound to evolve as well. The new research paradigm brings unique demands and challenges to the algorithmic computility, network transmission capacity, and data storage and management. Consequently, it is an urgent requirement for research informatization infrastructure platform to make technological breakthroughs in the areas of intelligent computility, large-scale data storage and high throughput read/write, cross-network software and hardware …

Overall Promotion Of Integrated Management And Utilization Of Saline-Alkali Land In Northwest China: Conditions, Challenges, And Recommendations, Qi Feng, Xinwei Yin, Meng Zhu, Jutao Zhang, Wei Liu, Haiyang Xi, Tengfei Yu, Linshan Yang, Wen Liu, Zhixiang Lu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Cultivated land is the lifeblood of grain production and the foundation for food security. Saline-alkali land in Northwest China is an important cultivated land reserve resource and a potential granary for guaranteeing national food security, so the high-quality promotion of comprehensive management and utilization of saline-alkali land in Northwest China is a strategic measure to achieve the goal of “storing grain in land and technology”. Based on a profound understanding of the great significance for promoting the integrated management and utilization of saline-alkali land in Northwest China, this study systematically summarizes the quantity, distribution pattern, and utilization potential of saline-alkali …

China’S Rare Earths Trade Flow Analysis: Trade Patterns And Strategic Insights, Linbin Tang, Peng Wang, Wei Chen, Yawen Han, Yuning Jin, Zilong Peng, Weiqiang Chen

Bulletin of Chinese Academy of Sciences (Chinese Version)

Rare earth elements are strategic critical metals that support low-carbon energy, aerospace, and defense technologies. Currently, China’s rare earth industry lacks competitiveness and faces the risk of “multidimensional pressures” in global competition. Therefore, it is crucial to systematically analyze the supply-demand and trade patterns of rare earths, accurately identify the bottlenecks and pain points in China’s entire rare earth industry chain, and provide strategies to transform China’s rare earth resource advantage into a strategic competitive edge. Based on customs trade data, this study traces the trade flows of various forms of rare earth products across the full industry chain in …

A Study On Common Characteristics And Mechanisms On Growth Of Strategic Scientists From Perspective Of Life Course Theory, Chenghua Lin, Weijia Zhang, Yanyi Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

This study was conducted on six renowned strategic scientists in China using the life cycle theory framework. The research explored the key competency characteristics, growth trajectories, and influencing factors in their growth process. The findings revealed that the capabilities of Chinese strategic scientists encompass four dimensions: scientific metacognition, strategic planning, team coordination, and spiritual leadership. These capabilities exhibit staged development characteristics, including phases of enlightenment, wisdom enhancement, and molding. They are influenced by a comprehensive range of factors, including the influence of others, resource conservation, and career construction. To further optimize the environment for cultivating and utilizing strategic scientists in …

How Should China Respond To “Pan-Data Sovereignty” Competition Among China, U.S., And Eu—An Analysis Based On The Digital Stack Model?, Yan Liu, Congjing Ran

Bulletin of Chinese Academy of Sciences (Chinese Version)

Data sovereignty has become deeply intertwined with various economic and social development factors such as technology, trade, economy, culture, society, and politics, leading to a “Pan-Data Sovereignty” competition pattern in the digital space. Through the digital stack model, which examines digital technologies in a layered framework, we can more clearly assess the competitive capacities in“Pan-Data Sovereignty” of China, United States, and European Union. The analysis identifies a three-tiered global “Pan-Data Sovereignty” competition structure among China, U.S., and EU, with each entity holding distinct advantages across various layers of the digital stack. Intense future competition is anticipated in fields such as …

Research And Reflection On Transformation Of Resource-Based Cities In China—A Case Study Of Datong City, Shanxi Province, Zhijian Xiong, Hong Zhao, Xiuli Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Currently, there are 262 resource-based cities in China, of which mature and declining cities account for 79.39%. These cities have made significant contributions to the country’s economic and social development, but now they are facing severe challenges and difficulties, and their transformation problems urgently need to be solved. This work studies the mechanism of resource-based transformation and proposes strategies for the transformation of resource-based cities: (1) Transformation should be comprehensive, balanced, and sustainable; (2) Transformation should fully leverage the leading role of the market while also taking into account the fundamental role of the government; (3) Transformation should fully leverage …

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Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

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Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

A Comprehensive Usability And Economic Analysis Of Heat-Related Wearable Technologies: Applications To Occupational Health, Ryan T. Cannady

Theses & Dissertations

The purpose of this research was to analyze the usability and economic considerations of real-time wearable technologies that are implemented in occupational settings to assess risk of heat stress and heat strain. The study population included current agriculture workers and Department of Energy (DOE), Environmental Management (EM) contractors. We employed a mixed-methods approach to comprehensively analyze the usability and economic considerations of heat-related technologies. Specifically, our approach assessed three distinct aspects the applications of these technologies in occupational settings to comprehensively address our research objective: (1) worker perceptions of heat-related wearable technologies, (2) field-based assessment of these heat-related wearable technologies, …

Enhancing Concrete Sustainability With Self-Healing Technologies, Al Shimaa Abdullatif

Theses and Dissertations

Thanks to its strength, durability and affordability, Portland cement concrete is the most commonly used building material worldwide. However, concrete cracking is inevitable due to numerous factors including shrinkage, exposure to external chemicals, internals reactions, excessive loads, to name but a few. Self-healing is a promising technique that can enable concrete to autogenously heal cracks and alleviate much of the damage. Such healing can without a doubt extend the service life with less need for external repair works therefore it contributes to sustainability. Over the years, several means of self-healing agents have been explored including bio-based procedures and the incorporation …

Beyond Bindis, Bhajis, Bangles And Bhangra: Promoting Multiculturalism In Primary Schools In Predominantly White British Places, Suparna Bagchi

School of Law, Humanities and Social Sciences

Twenty-first-century education as a powerful means of knowledge will possibly be shaped by the emphasis it places on having classrooms that are race-conscious and multicultural. The present article is based on a doctoral study that explores an under-researched area: experiences and understanding of multiculturalism in mainstream primary schools situated in the predominantly White places of Southwest England. The study was underpinned by a sociocultural theoretical framework; data were collected through semi-structured interviews with the adult participants, students’ classroom activities, and documentary analysis of school displays. The article focuses on the data generated from the students’ classroom activities. Findings show differences …

Womb, Gravity, And Space: Shifting Towards The Cerebellum-Basal Ganglia Paradigm In Dystonia, Diego Iacono

Department of Neurology Faculty Papers

No abstract provided.

Fail-Safe Logic Design Strategies Within Modern Fpga Architectures, Priya A. Bhakta

Electrical and Computer Engineering ETDs

Field Programmable Gate Arrays (FPGAs) are vulnerable to radiation-induced single event upsets (SEUs) and fault injection attacks, requiring the use of redundancy techniques such as fail-safe computing. Fail-safe computing refers to computing systems that revert to a non-operational safe state when a fault occurs. This work investigates circuit-level techniques and implements fail-safe computing processes as mitigation for SEUs and fault injection attacks on FPGAs. The analysis reveals vulnerabilities that exist in FPGAs over those in application-specific integrated circuits (ASIC); thus, requiring a more elaborate network of redundant circuits and checking logic. The reconfiguration capability of FPGAs adds complexity to fail-safe …

Ifrd1 Is Required For Maintenance Of Bladder Epithelial Homeostasis, Bisiayo E Fashemi, Amala K Rougeau, Arnold M Salazar, Steven J Bark, Rayvanth Chappidi, Jeffrey W Brown, Charles J Cho, Jason C Mills, Indira U Mysorekar

2020-Current year OA Pubs

The maintenance of homeostasis and rapid regeneration of the urothelium following stress are critical for bladder function. Here, we identify a key role for IFRD1 in maintaining urothelial homeostasis in a mouse model. We demonstrate that the murine bladder expresses IFRD1 at homeostasis, particularly in the urothelium, and its loss alters the global transcriptome with significant accumulation of endolysosomes and dysregulated uroplakin expression pattern. We show that IFRD1 interacts with mRNA-translation-regulating factors in human urothelial cells. Loss of

Bile Acids In Inflammatory Bowel Disease: From Pathophysiology To Treatment, Samantha H Bai, Arun Chandnani, Siyan Cao

2020-Current year OA Pubs

Inflammatory bowel disease (IBD) is a chronic condition that affects about 7 million people worldwide, and new therapies are needed. Understanding the complex roles that bile acids (BAs) play in IBD may lead to the development of novel IBD treatments independent of direct immunosuppression. This review discusses the latest discoveries in the roles BAs play in IBD pathogenesis and explores how these discoveries offer promising new therapeutic targets to treat IBD and improve patient outcomes. Several therapies discussed include specific BA receptor (BAR) agonists, dietary therapies, supplements, probiotics, and mesenchymal stem cell therapies that have all been shown to decrease …

Regional Differences In Three-Dimensional Fiber Organization, Smooth Muscle Cell Phenotype, And Contractility In The Pregnant Mouse Cervix, Christopher J Hansen, Christine M O'Brien, Et Al.

2020-Current year OA Pubs

The orientation and function of smooth muscle in the cervix may contribute to the important biomechanical properties that change during pregnancy. Thus, this study examined the three-dimensional structure, smooth muscle phenotype, and mechanical and contractile functions of the upper and lower cervix of nongravid (not pregnant) and gravid (pregnant) mice. In gravid cervix, we uncovered region-specific changes in the structure and organization of fiber tracts. We also detected a greater proportion of contractile smooth muscle cells (SMCs), but an equal proportion of synthetic SMCs, in the upper versus lower cervix. Furthermore, we revealed that the lower cervix had infrequent spontaneous …

Pancreaticoduodenectomy In Trauma Patients With Grade Iv-V Duodenal Or Pancreatic Injuries: A Post Hoc Analysis Of An East Multicenter Trial, Rachel Leah Choron, Rami Al-Aref, Jordan Michael Kirsch, Et Al.

2020-Current year OA Pubs

INTRODUCTION: The utility of pancreaticoduodenectomy (PD) for high-grade traumatic injuries remains unclear and data surrounding its use are limited. We hypothesized that PD does not result in improved outcomes when compared with non-PD surgical management of grade IV-V pancreaticoduodenal injuries.

METHODS: This is a retrospective, multicenter analysis from 35 level 1 trauma centers from January 2010 to December 2020. Included patients were ≥15 years of age with the American Association for the Surgery of Trauma grade IV-V duodenal and/or pancreatic injuries. The study compared operative repair strategy: PD versus non-PD.

RESULTS: The sample (n=95) was young (26 years), male (82%), …