Digital Commons Network^™

Regulated Drug Delivery Via Controlled Degradable Chondroitin Sulfate Particles, Nurettin Sahiner, Ramesh Ayyala

USF Patents

Disclosed herein are crosslinked chondroitin sulfate particles crosslinked chondroitin sulfate particle polyelectrolytes. The particles are useful in drug delivery applications. The particles may be used to treat various conditions, including bacterial and fungal infections.

Device For Targeted Feature-Specific Sensory Therapy, David Eddins, Joseph Walton

USF Patents

A device and method that supplements sensory input, thereby providing a supplemented sensory environment, to induce plasticity within the central nervous system that effectively overcomes sensory-neural processing deficits or strengthens specific sensory-neural abilities. In one implementation, ear-level hearing devices are used to deliver therapeutic sound with specific acoustic features that serve as archetypes of stimulus features for which sensory-neural processing is compromised by a sensory-neural deficit.

Door Opening System And Method, Kyle Brandon Reed

USF Patents

A door opener for a door includes a frame coupled to the door and a wheel rotatably supported by the frame. The wheel, including its position relative to the door and frame, as well as its shape, are configured to convert a downward force applied by a user's foot into a lateral force that opens the door by rotating the wheel in contact with the floor.

Gender Equity And Coffee Agroforestry: The Environmental And Social Impacts Of Commodity Production In Latin America, Suzanna Lloyd

Student Theses 2015-Present

This paper addresses the environmental and social implications of coffee growth and production in Latin America. Women contribute significantly to the ownership of coffee farms and labor of coffee production; however, there is a lack of resources and financial compensation for their work. Chapter One provides both quantitative and qualitative data on the environmental impacts of coffee plantations compared to agroforestry methods of coffee production in Latin America. This chapter defines basic terms, differentiates coffee species and mode of production, and explains the ecosystem services of biodiverse, tropical farms. Chapter Two highlights the patriarchal nature of Latin American agriculture systems …

Digital Twin And Cybersecurity In Additive Manufacturing, Lidong Wang

Journal of Cybersecurity Education, Research and Practice

Additive manufacturing (AM) has been applied to automotive, aerospace, medical sectors, etc., but there are still challenges such as parts’ porosity, cracks, surface roughness, intrinsic anisotropy, and residual stress because of the high level of thermal gradient. It is significant to conduct the modeling and simulation of the AM process and achieve quality products. Digital Twin (DT) can help AM with forecasting defects/errors through simulation and real-time process monitoring. DT is a concept of Industry 4.0, and its digital structure reflects the real-time behaviors of a cyber-physical or physical system. This paper introduces the progress of DT applications in AM, …

Order Confirming Disclosure Statement And Disclosure Statement

Catholic Dioceses in Bankruptcy

No abstract provided.

Improved Adherence To Lipid Screening In The Pediatric Cardiology Clinic: A Quality Improvement Project, Rachel Magnan, Thomas Murphy, Lauren Rosenthal, Aparna Prasad, Anjali Chelliah, Stuart Kaufman, Donna Timchak, Lindsey Mcphillips, Saira Siddiqui

Department of Pediatrics Faculty Papers

INTRODUCTION: Lipid screening identifies at-risk patients to facilitate cardiovascular risk reduction. National pediatric guidelines recommend universal lipid screening between 9-11 and 17-21 years of age. We aimed to improve adherence to lipid screening for all age-appropriate outpatient pediatric cardiology visits from a baseline of 35% to 90% between November 2021 and July 2023.

METHODS: All outpatient visits for patients 9-11 and 17-21 years were included. Chart review and an Epic electronic health record report identified patients screened, lipid test results, and need for further testing. A P-chart was generated. After establishing a baseline for 8 weeks, interventions, including an Epic …

Determination Of The Kinetic Parameters Of Cholesterol Oxidation Using Cholesterol Oxidase From Streptomyces Sp., Meka Saima Perdani, Heri Hermansyah, Muhamad Sahlan, Dwini Normayulisa Putri, Teguh Pambudi, Anggi Khairina Hanum Hasibuan

Makara Journal of Technology

Cholesterol oxidase (CO) was successfully produced from Streptomyces sp. via the submerged fermentation method, and 69 U/mL enzyme activity was obtained. This study aimed to determine cholesterol oxidation kinetics and the production of CO as a catalyst. The enzyme was diluted to 0.15, 0.075, and 0.00375 U/mL for the oxidation reaction. The substrate was also prepared in three concentrations: 3.23, 6.46, and 12.93 mM. The optimization of conditions for enzymatic cholesterol oxidation was investigated through measurement of the effect of initial cholesterol and enzyme concentrations. Cholesterol concentration was rapidly measured via high-performance liquid chromatography (HPLC). The kinetics of CO were …

From The Ocean To Our Kitchen Table: Anthropogenic Particles In The Edible Tissue Of U.S.. West Coast Seafood Species, Summer D. Traylor, Elise F. Granek, Marilyn Duncan, Susanne Brander

Environmental Science and Management Faculty Publications and Presentations

Microplastics (MPs) and other anthropogenic particles (APs) are pervasive environmental contaminants found throughout marine and aquatic environments. We quantified APs in the edible tissue of black rockfish, lingcod, Chinook salmon, Pacific herring, Pacific lamprey, and pink shrimp, comparing AP burdens across trophic levels and between vessel-retrieved and retail-purchased individuals. Edible tissue was digested and analyzed under a microscope, and a subset of suspected APs was identified using spectroscopy (μFTIR). Anthropogenic particles were found in 180 of 182 individuals. Finfish contained 0.02–1.08 AP/g of muscle tissue. In pink shrimp (Pandalus jordani), the average AP/g was 10.68 for vessel-retrieved and …

Tacrolimus- And Mycophenolate-Mediated Toxicity: Clinical Considerations And Options In Management Of Post-Transplant Patients, Alan D. Kaye, Shivam S. Shah, Coplen D. Johnson, Adalyn S. De Witt, Austin S. Thomassen, Charles P. Daniel, Shahab Ahmadzadeh, Sridhar Tirumala, Kristin N. Bembenick, Adam M. Kaye, Sahar Shekoohi

Pacific Faculty Work

Tacrolimus and mycophenolate are important immunosuppressive agents used to prevent organ rejection in post-transplant patients. While highly effective, their use is associated with significant toxicity, requiring careful management. Tacrolimus, a calcineurin inhibitor, is linked to nephrotoxicity, neurotoxicity, metabolic disturbances such as diabetes mellitus and dyslipidemia, and cardiovascular complications such as hypertension and arrhythmias. Mycophenolate, a reversible inhibitor of inosine monophosphate dehydrogenase, frequently causes gastrointestinal disturbances, including diarrhea and colitis, as well as hematologic side effects like anemia and leukopenia, which increase infection risk. Therapeutic drug monitoring (TDM) and pharmacogenomics have emerged as essential strategies for mitigating these toxicities. TDM ensures …

Geneseo Authors Celebration 2024, Milne Library

Geneseo Authors Celebration

Milne Library began a tradition of celebrating faculty authorship in 2009 with a series of workshops and a celebration in collaboration with the Teaching and Learning Center. Over the years it has evolved to more accurately reflect on the variety of academic and creative work done here at Geneseo. The annual Geneseo Authors Celebration is an opportunity for the Library and the campus to celebrate the faculty and truly acknowledge the time and effort that faculty have invested into creating exceptional works that contribute to the scholarly discussions taking place in their disciplines.

In late fall 2024, when the Geneseo …

Epithelial Barrier Hypothesis: A Systematic Review, Krishna Patel, Peter Lio

Student Publications

Background

The epithelial barriers, which include the skin, the gut, and the respiratory lining, play a crucial role in protecting the body from pathogens and environmental threats. Many harmful toxins are increasingly part of modern life. The increase in usage of these damaging agents in conjunction with the increase in allergic inflammatory conditions suggests that the “epithelial barrier hypothesis”—the concept that damage to the epithelia by external agents can result in dysbiosis, inflammation, and allergy—may explain the rise in these conditions seen in the developed world.

Objective

We sought to assess the evidence for the epithelial barrier hypothesis, with particular …

Generative Ai In Shariah Advisory In Islamic Finance: An Experimental Study, Muhammad Noman Jokhio, Muhammad Asif Jaffer

Business Review

Islamic banks adhere strictly to Shariah principles in all operations and offerings, creating a demand for experts proficient in Shariah-compliant banking and finance. This study investigates the potential of using generative AI, specifically Large Language Models (LLMs), to provide Shariah advisory in complex Islamic financing scenarios. The research evaluates general purpose public LLMs—such as ChatGPT, Gemini, and Meta AI—on their ability to identify Shariah compliance issues, cite relevant Shariah references, and propose actionable guidance for resolving compliance challenges in complex Islamic financing scenarios. A qualitative approach was used. The experimental study involved creation of complex, realistic financing scenarios requiring Shariah …

Population-Based Study Of The Epidemiology Of Stiff Person Syndrome In A Large Colorado-Based Health System, Paul Daniel Crane, Stefan Sillau, Renee Dreher, Rikki Fix, Phillip Winters, Russell Van Coevering, Eric Engebretson, Brooke Valdez, Elizabeth Matthews, Kavita V. Nair, Aaron M. Carlson, Amanda L. Piquet

Student Publications

Background and objectives: Stiff person syndrome spectrum disorder (SPSD) is a rare autoimmune disorder characterized by progressive muscle stiffness and painful spasms with an estimated prevalence of 1-2 cases per million people. Population-based epidemiologic studies are lacking because of both poor patient capture and the lack of standardized diagnostic criteria. Objectives of this study were to describe the incidence and prevalence of SPSD within the University of Colorado Health (UCH) system and apply previously proposed published criteria for SPSD within this population.

Methods: We queried Health Data Compass, an electronic health data repository for a large academic health care system, …

Glucose-Lowering Agents Developed In The Last Two Decades And Their Perioperative Implications, Basavana Goudra, Geno Merli, Michael Green

Department of Anesthesiology Faculty Papers

The last two decades have provided far more options f both patients and their physicians in the treatment of diabetes mellitus. While dipeptidyl peptidase-4 inhibitors (DPP-4is) and glucagon-like peptide 1 receptor agonists (GLP-1RAs) have been approved for nearly two decades, sodium-glucose cotransporter 2 inhibitors (SGLT-2is) are relatively new. Of interest to perioperative physicians, these drugs present specific perioperative concerns, prompting many societies to issue guidelines. Retained gastric contents due to slow gastric emptying is a significant drawback of GLP-1RAs, increasing the risk of aspiration. Recommendations include withholding GLP-1RAs for a predefined period of time, performing gastric ultrasound to evaluate gastric …

Digital Cognitive Behavioral Therapy Vs Education For Pain In Adults With Sickle Cell Disease, Charles R. Jonassaint, Christina M. Lalama, C. Patrick Carroll, Sherif M. Badawy, Megan E. Hamm, Jennifer N. Stinson, Chitra Lalloo, Santosh L. Saraf, Victor R. Gordeuk, Robert M. Cronin, Nirmish Shah, Sophie M. Lanzkron, Darla Liles, Julia A. O'Brien, Cassandra Trimnell, Lakiea Bailey, Raymona H. Lawrence, Leshana Saint Jean, Michael Debaun, Laura M. De Castro, Tonya M. Palermo, Kaleab Z. Abebe

Department of Medicine Faculty Papers

Despite the burden of chronic pain in sickle cell disease (SCD), nonpharmacological approaches remain limited. This multisite, randomized trial compared digital cognitive behavioral therapy (CBT) with a digital pain/SCD education program ("Education") for managing pain and related symptoms. Participants were recruited virtually from seven SCD centers and community organizations in the United States. Adults (aged ≥18 years) with SCD-related chronic pain and/or daily opioid use were assigned to receive either CBT or Education for 12 weeks. Both groups used an app with interactive chatbot lessons and received personalized health coach support. The primary outcome was the change in pain interference …

Loss Of Chop Prevents Joint Degeneration And Pain In A Mouse Model Of Pseudoachondroplasia

Faculty, Staff and Student Publications

Pseudoachondroplasia (PSACH), a severe dwarfing condition characterized by impaired skeletal growth and early joint degeneration, results from mutations in cartilage oligomeric matrix protein (COMP). These mutations disrupt normal protein folding, leading to the accumulation of misfolded COMP in chondrocytes. The MT-COMP mouse is a murine model of PSACH that expresses D469del human COMP in response to doxycycline and replicates the PSACH chondrocyte and clinical pathology. The basis for the mutant-COMP pathology involves endoplasmic reticulum (ER) stress signaling through the PERK/eIF2α/CHOP pathway. C/EBP homologous protein (CHOP), in conjunction with a TNFα inflammatory process, upregulates mTORC1, hindering autophagy clearance of mutant COMP …

Muqarnas In Damascus: A Forgotten Treasure’S History, Inception And Geometry, Nahed Jawad Chakouf

All Works

The architecture of the Islamic world encompasses both religious and secular buildings that are unified by the use of a common architectural language, which includes architectural elements such as minarets, domes and arches, ornamental details, and vaulting with the use of muqarnas. The study provides a broad overview of the development of Islamic architecture, focusing on Damascus, the early Islamic period, the mid-Islamic period and the late Islamic period. The late Islamic period includes Ottoman art, with architecture influenced by Byzantine, Persian, Armenian, and Mamluk artefacts, but differs from their predecessors. The researcher undertook a geometric analysis of the muqarnas …

State Of Utah V. Alberto Frank Hernandez : Reply Brief, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

An appeal from a judgment of conviction of aggravated assault, a third-degree felony; and obstructing justice, a class A misdemeanor; in the Third Judicial District Court, Salt Lake County, State of Utah, the Honorable Heather Brereton, presiding. Appellant is incarcerated.

CONNER NELSON (18064) Assistant Solicitor General SEAN D. REYES (7969) Utah Attorney General Attorney for Appellee

ERICK GRANGE (18000) Salt Lake Legal Defender Assoc. Attorney for Appellant

Staff Education To Expand Clinicians’ Knowledge Of Standardized Screening Tools In Addiction Treatment, Uwaezu Mercy Kalu

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project focuses on a staff education initiative to enhance clinicians' knowledge and application of standardized screening tools for co-occurring mental health disorders in addiction treatment settings. The project addresses inconsistencies in screening practices that contribute to undiagnosed mental health conditions, adversely affecting patient outcomes. Clinicians were trained to use three validated tools: PHQ-9 for depression, GAD-7 for anxiety, and MDQ for bipolar disorder. The intervention involved a structured educational program with pre- and post-intervention assessments. Results showed significant improvement in clinicians' knowledge, with pretest scores averaging 4.6 and posttest scores averaging 6.0 (p < 0.05). The findings highlight the effectiveness of standardized tools in improving diagnostic consistency and care quality. Key recommendations include integrating these tools into routine clinical assessments, standardizing documentation practices, fostering interdisciplinary collaboration, and establishing continuous quality improvement processes. Despite limitations such as small sample size and single-site implementation, this project underscores the critical role of staff education in promoting evidence-based practices to improve patient outcomes and supports positive social change in addiction treatment settings.

Special Education Co-Teachers’ Role In The Adoption Of Information And Communication Technology Tools In Inclusive Classrooms, Amy Hysick

Walden Dissertations and Doctoral Studies

Co-teaching is a common service delivery model where a general and special education teacher are paired in the same classroom, though little is known about the experiences of secondary special education co-teachers in the adoption and use of information and communication technology (ICT) tools in inclusive, co-taught classrooms. The purpose of this qualitative study was to investigate the experiences of special education co-teachers in the adoption and use of ICT tools. Venkatesh et al.’s unified theory of the acceptance and use of technology was the conceptual framework for the study. The research question focused on the experiences of special education …

Perceptions Of Early Childhood System Partners On Career Pathways, Melissa Larson Busby

Walden Dissertations and Doctoral Studies

Researchers have found high-quality early childhood teachers are crucial to high-quality programs for young children. Despite this, there is a significant need for more highly qualified teachers in a southwestern state. The purpose of the qualitative study was to explore the perceptions of early childhood education (ECE) systems partners in one southwestern state regarding the current systems, structures, and policies related to career pathways through the high school, community college, and university levels. The conceptual framework for this study was based on von Bertalanffy’s general systems theory and systems thinkers such as Senge, who detail the complex interactions between systems …

Perceptions Of Black Women’S Portraits Of Beauty In Essence Magazine, Dr. Rachel Mingo

Walden Dissertations and Doctoral Studies

Historically, beauty standards in the United States were rooted in White ideals, influencing media portrayals of Black women to align with White features like lighter skin and straightened hair. Although recent studies suggest a slow shift toward a more diverse representation of Black beauty, depictions in magazines still predominantly reflect mainstream Western beauty ideals, leading to potential negative impacts on Black women’s self-esteem and body image. The purpose of this generic qualitative study was to explore how young Black women, ages 18–25, perceive portrayals of Black beauty in Essence magazine. Black feminist thought constituted the theoretical basis for this study. …

Hiring, Training, And Retaining Mental Health Professionals At Rural Wisconsin Correctional Facilities, Jessica Kallenbach

Walden Dissertations and Doctoral Studies

Correctional facilities in rural Wisconsin have noted a shortage of trained mental health professionals to provide care. Common barriers to providing mental health services in rural areas are the availability and accessibility of mental health professionals. Due to limited access to financial and career benefits, mental health professionals tend to avoid working in these areas. The purpose of this qualitative phenomenological study was to explore the lived experience of mental health professionals, administrators, and supervisors in hiring, training, and retaining staff in rural Wisconsin correctional facilities. Bandura’s social learning theory was used to guide the study. Data was collected from …

New Graduate Nurses' Experiences Of Burnout As They Transition To Practice, Stacy Beth Elliott

Walden Dissertations and Doctoral Studies

Transitioning from nursing school to professional practice is a critical and challenging period for newly graduated nurses. Transition to professional nursing practice is particularly stressful in the first 3 years as new graduates adapt to the high acuity of patient care, which can result in burnout. The purpose of this qualitative study, guided by the conservation of resource theory, was to understand how new graduate nurses describe their experiences of burnout as novice nurses transition in the first 3 years of nursing practice. Fourteen nurses were interviewed using a semi-structured interviews, and Saldana’s two-cycle analysis was used for data interpretation, …

Corporate Social Responsibility, Economic, Ethical-Legal, And Philanthropic Performances In Ghanaian Banks Using Big Data Analytics, Mohammed Alhassan Adams

Walden Dissertations and Doctoral Studies

Corporate social responsibility (CSR) is becoming increasingly essential for Ghanaian banks to reconcile financial growth with ethical, legal, and civic obligations amid escalating societal expectations. The specific research problem was that the extent to which Ghanaian banks employed big data analytics (BDA) to boost multidimensional CSR performance encompassing economic, ethical-legal, and philanthropic dimensions was unknown. The purpose of this quantitative correlational study was to examine the potential impacts of BDA use and overall CSR performance on Ghanaian banks’ economic, ethical-legal, and philanthropic dimensions of CSR. Using stakeholder theory and a resource-based view, BDA was applied as a strategic tool for …

Effects Of Bilingual Language Exposure On Toddlers With Autism Spectrum Disorder, Sarah Phillips, Amelia Yanchik, Heather Jung, Peter Vietze, Leah Esther Lax

Department of Psychology Faculty Scholarship and Creative Works

Research analyzing the effects of bilingual language exposure on children with autism spectrum disorder (ASD) has increased in frequency. Utilizing the Bayley Scales of Infant and Toddler Development—Third Edition, the current study analyzed the effects of bilingual language exposure and age on language development, cognitive development, and social emotional development in toddlers with ASD. Older children demonstrated higher language scores than younger children. The interaction between ASD and bilingualism did not yield statistical significance for language, cognitive, or social emotional scores; however, the interaction between age and bilingualism was found to be significant. Age may have more of an influence …

Matter Of Syllman V. New York State Div. Of Hous. & Community Renewal

All Decisions

In this Article 78 proceeding, the tenant challenged a rent increase granted for a major capital improvement involving roof and facade repairs. The DHCR's determination was upheld as rational and not arbitrary or capricious. The court reaffirmed that administrative decisions must stand unless lacking sound reasoning or factual support. Judgment dismissed the tenant's petition, validating the rent increase for the landlord.

Clermont York Assoc. Llc V. Zgodny

All Decisions

In this nonpayment proceeding, the landlord moved to restore the case to the court calendar after a nine-year delay following an interlocutory appeal. The court denied the motion, finding that the landlord failed to demonstrate a reasonable excuse for the lengthy delay, a crucial factor for granting restoration motions. The court emphasized the importance of diligence in prosecuting legal claims and the potential prejudice to the tenant from such a significant delay.

Lower-Intensity Cpx-351 Plus Venetoclax Induction For Adults With Newly Diagnosed Aml Unfit For Intensive Chemotherapy, Geoffrey L Uy, Vinod Pullarkat, Praneeth Baratam, Robert K Stuart, Roland B Walter, Eric S Winer, Qi Wang, Stefan Faderl, Divya Chakravarthy, Diane Menno, Ronald S Cheung, Tara L Lin

2020-Current year OA Pubs

Preclinical data suggest a rationale for combining CPX-351, a dual-drug liposomal encapsulation of daunorubicin and cytarabine, with venetoclax, a B-cell lymphoma-2 inhibitor. This phase 1b study evaluated lower-intensity CPX-351 combined with venetoclax in adults with acute myeloid leukemia (AML) considered unfit/ineligible for intensive chemotherapy. In a dose-exploration phase using a 3+3 design, patients received stepwise dosing of CPX-351 IV on days 1 and 3 plus venetoclax 400 mg orally on days 2 to 21 per cycle to determine the recommended phase 2 dose (RP2D) for this combination. During the expansion phase, additional patients received CPX-351 plus venetoclax at the identified …