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Articles 278761 - 278790 of 5207185
Full-Text Articles in Entire DC Network
Penerapan Tutor Sebaya Dan Model Snowball Throwing Untuk Meningkatkan Kemampuan Berpikir Kritis Siswa Smp, Didi Suhendra, Neni Wahyuningtyas, Budi Arti Andjajani
Penerapan Tutor Sebaya Dan Model Snowball Throwing Untuk Meningkatkan Kemampuan Berpikir Kritis Siswa Smp, Didi Suhendra, Neni Wahyuningtyas, Budi Arti Andjajani
Journal of Innovation and Teacher Professionalism
This study aims to analyze the effectiveness of the application of peer tutors and snowball throwing models in improving critical thinking skills of students in class IX-F SMP Negeri 7 Malang who have kinesthetic and visual intelligence in social studies learning. The research method used is Classroom Action Research (CAR) through the application of peer tutors and snowball throwing models with a qualitative descriptive approach. The results showed a significant increase in critical thinking skills, participation, and activeness of students from cycle I to cycle II. Thus, this approach proved effective in improving the quality of learning and teaching in …
Pelaksanaan Program Adiwiyata Untuk Mewujudkan Karakter Peduli Lingkungan Di Smp Negeri, Faula Anis Hatami, Nurul Ratnawati
Pelaksanaan Program Adiwiyata Untuk Mewujudkan Karakter Peduli Lingkungan Di Smp Negeri, Faula Anis Hatami, Nurul Ratnawati
Journal of Innovation and Teacher Professionalism
One initiative that attempts to raise knowledge and foster compassionate attitudes toward the environment is the Adiwiyata initiative. The aim of this research is to evaluate the impact of the Adiwiyata Program's implementation on SMP Negeri 2 Pakis environmental care character. The study employs a case study methodology and is qualitative in nature. Literature reviews, interviews, and observation are some methods of gathering data. The outcomes demonstrated how successful the SMP Negeri 2 Pakis Adiwiyata Program was in helping students develop environmentally conscious character traits. This is demonstrated by the way that student behavior, knowledge, and actions regarding the environment …
Pengaruh Model Pembelajaran Project Based Learning (Pjbl) Berbantuan Aplikasi Edmodo Terhadap Kemampuan Berpikir Kreatif Siswa Pada Mata Pelajaran Geografi Kelas Xi, Erwinda Ika, Alfyananda Kurnia Putra, Nailul Insani
Pengaruh Model Pembelajaran Project Based Learning (Pjbl) Berbantuan Aplikasi Edmodo Terhadap Kemampuan Berpikir Kreatif Siswa Pada Mata Pelajaran Geografi Kelas Xi, Erwinda Ika, Alfyananda Kurnia Putra, Nailul Insani
Journal of Innovation and Teacher Professionalism
The research aims to investigate the effect of the project based learning model with the aid of the Edmodo application on students' creative thinking skills in geography class XI. Improper experiments were used in this research, with the subjects of class XI IPS 1 as the experimental class and XI IPS 3 as the control class. The data collection technique was in the form of pretest and post written tests with ten questions. The Mann Whitney test was chosen for the data analysis technique. The results of the Mann Whitney test show a significance number of 0.009 less than 0.05, …
The Impact Of Competition Law On The Digital Markets Act – On The Interrelationship Between Regulations And Future Prospects, Iga Małobęcka-Szwast
The Impact Of Competition Law On The Digital Markets Act – On The Interrelationship Between Regulations And Future Prospects, Iga Małobęcka-Szwast
internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)
Competition law, or rather the experience of its application in digital markets by the European Commission, national competition authorities (NCAs) and courts (in particular the Court of Justice of the European Union), has had a key influence on shaping the content of the Digital Markets Act (DMA). The article shows the complex relationship between competition law and the DMA, and discusses examples of decisions of the Commission and national competition authorities that have had an impact on the shaping of the catalogue of obligations imposed on gatekeepers under the DMA. The role of national competition authorities in ensuring the effectiveness …
European Origins Of The Polish Leniency Programme, Marcin Kulesza
European Origins Of The Polish Leniency Programme, Marcin Kulesza
internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)
The article presents a review of the Anglo-European origins of the Polish leniency programme, introduced into national antitrust legislation in 2004 in close connection with Poland’s accession to the EU. It presents the history and general shape of the US programme as well as the history of the EU programme, as well as the implementation of leniency into the 2000 Competition and Consumer Protection Act in force on 01/05/2024, the date of Poland’s accession to the EU.
Time For Summaries, Time For New Challenges, Grzegorz Materna
Time For Summaries, Time For New Challenges, Grzegorz Materna
internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)
From the lead editor
Autonomiczna Wymiana Informacji Jako Ograniczenie Konkurencji Ze Względu Na Cel Glosa Do Wyroku Trybunału Sprawiedliwości W Sprawie Instytucji Kredytowych W Portugali (C-298/22), Kamil Dobosz
internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)
The commented case pertains to the exchange of information that took place over many years, by basically all significant credit institutions in Portugal. Unlike other instances of the exchange of information, the latter had a standalone character in this case, as it did not serve or facilitate another, main anticompetitive behavior, which would amount to a concerted practice or agreement. The key to this case was to establish whether a mere exchange of information may amount to unlawfulness. While for the sake of a restriction ‘by effect’, an in-depth effects- -oriented analysis thereof appears obvious, the Court of Justice had …
The Impact Of The Judgment In Case C-211/22 Super Bock On The Assessment Of Vertical Pricing Agreements, Krzysztof Kanton
The Impact Of The Judgment In Case C-211/22 Super Bock On The Assessment Of Vertical Pricing Agreements, Krzysztof Kanton
internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)
The article discusses the impact of the judgment of the Court of Justice of the European Union (CJEU) in the Super Bock case (C-211/22) on the assessment of vertical pricing agreements under EU competition law. The judgment underscores the need to apply an economic approach when assessing whether an agreement, which provides for the setting of fixed or minimum resale prices, constitutes a restriction of competition ‘by object’. In this judgment, the CJEU rejects the previous formalistic approach – present in the practice of the EC and NCAs – which automatically qualified RPMs as anti-competitive, without analyzing its economic and …
(R)Ewolucja Stosowania Prawa Konkurencji Ue Do Sportu W Najnowszym Orzecznictwie Trybunału Sprawiedliwości Unii Europejskiej, Wojciech Lewandowski
(R)Ewolucja Stosowania Prawa Konkurencji Ue Do Sportu W Najnowszym Orzecznictwie Trybunału Sprawiedliwości Unii Europejskiej, Wojciech Lewandowski
internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)
The Court of Justice of the European Union delivered three judgments on 21/12/2023 modifying the functioning of the European model of sport. In the judgments of: the European Super League ( C-333/21), the Royal Antwerp Football Club (C-680/21), and the International Skating Union (C-124/21 P), EU’s most important judicial institution undertook a comprehensive and orderly interpretation of Articles 101, 102 and 106 of the TFEU, applying these provisions to the activities of sports federations in relation to the organization of professional sports competitions in Europe. The purpose of this text is to analyze the most relevant elements concerning the modification …
Entire Issue Vol. 13 No. 4
internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)
Vol 13(4)
Cultural Adaptation And Environmental Challenges: A Case Study Of Nubian Communities In Egypt Through The Lens Of Cultural Ecology Theory, Imam Wicaksono, Sherif Sa’Ad Algayyar, Ahmed Hassan Mohammad Hassan
Cultural Adaptation And Environmental Challenges: A Case Study Of Nubian Communities In Egypt Through The Lens Of Cultural Ecology Theory, Imam Wicaksono, Sherif Sa’Ad Algayyar, Ahmed Hassan Mohammad Hassan
Journal of Middle East and Islamic Studies
The purpose of this study is to investigate how the ecological changes brought about by the building of the Aswan Dam have affected the Nubian community's social structure, cultural identity, and coping mechanisms. The study emphasizes how important it is to comprehend how people interact with their surroundings considering modernization, which frequently jeopardizes the viability of regional customs. In addition to a literature review approach, a thematic analysis grounded in Julian Steward's cultural ecology theory—which highlights how societies adjust to changes in their physical surroundings—was used. The results show that ecological changes have profoundly impacted the Nubian people's cultural rites, …
Counselors’ Mind-Skills And Self-Compassion During Counseling Service, Eni Rindi Antika, Mulawarman Mulawarman, Bobby Ardhian Nusantara, Tivanny Octasya, Vip Brilliant Stoic, Mirabai Bhana, Abi Fa’Izzarahman Prabawa
Counselors’ Mind-Skills And Self-Compassion During Counseling Service, Eni Rindi Antika, Mulawarman Mulawarman, Bobby Ardhian Nusantara, Tivanny Octasya, Vip Brilliant Stoic, Mirabai Bhana, Abi Fa’Izzarahman Prabawa
Jurnal Kajian Bimbingan dan Konseling
The purpose of this study was to determine the level of mind skills and self-compassion of school counselors in counseling services. The research method used quantitative with a cross-sectional survey research design. The instruments used in this study were mind-skills test instruments and self-compassion scales. The test on the validity and reliability of research instruments was performed using two ways. The validity of the mind-skills test instrument uses the point biserial technique because the data was dichotomous (true or false). The validity test of the self-compassion scale was carried out with the Pearson product-moment correlation point using an error level …
Self-Compassion And Peer Social Support: Do They Influence Self-Efficacy In Career Decision Making Of Generation Z Students?, Wildan Madani, Helli Ihsan, Farhan Zakariyya
Self-Compassion And Peer Social Support: Do They Influence Self-Efficacy In Career Decision Making Of Generation Z Students?, Wildan Madani, Helli Ihsan, Farhan Zakariyya
Jurnal Kajian Bimbingan dan Konseling
This study aims to determine the effect of self-compassion and peer social support on career decision-making self-efficacy (CDMSE) among Generation Z college students in Indonesia. This study uses quantitative methods with a regression analysis approach. Sampling was conducted using non-probability sampling techniques with an accidental sampling approach. This study involved 367 active college students from Generation Z, aged 18-24, residing or studying in the metropolitan area of Greater Bandung. Greater Bandung was chosen as the research location because it represents the characteristics of Generation Z in Indonesia. The city is a center of education and culture with diverse higher education …
Exploring The Impact Of Self-Control, Motivation, And Resilience On Students' Self-Compassion, Diani Akmalia Apsari, Adi Atmoko, Ika Andrini Farida, Nur Eva, Augusto Da Costa, Aidah Fuadiyah
Exploring The Impact Of Self-Control, Motivation, And Resilience On Students' Self-Compassion, Diani Akmalia Apsari, Adi Atmoko, Ika Andrini Farida, Nur Eva, Augusto Da Costa, Aidah Fuadiyah
Jurnal Kajian Bimbingan dan Konseling
The core purpose of Pendidikan Profesi Guru Prajabatan (PPG) is to educate prospective teachers to become professional teachers. To achieve this goal, students requires psychological abilities when facing challenges such as dense and demanding tasks based on the curriculum that must be completed in 2 semesters. This study aims to (1) test the theoretical model of regression of self-compassion, and (2) determine the contribution of self-control, motivation, and resilience to self-compassion in PPG students. This study used a causal relationship design. Data were collected with (1) Brief Self Control Scale, (2) The Academic Motivation Scale, (3) The Connor-Davidson Resilience Scale, …
The Voice Of The Voiceless: Countering The Festival And Elevating Reyog Obyokan As Cultural Capital, Albert Tallapessy, Ikwan Setiawan
The Voice Of The Voiceless: Countering The Festival And Elevating Reyog Obyokan As Cultural Capital, Albert Tallapessy, Ikwan Setiawan
Paradigma: Jurnal Kajian Budaya
This article examines two performance models of Reyog Ponorogo: the festival model and the obyokan model. These two competing models represent differing perspectives on one side, the interests of the artists and the community, and on the other, the interests of the state. By applying cultural studies theories, particularly those of representation and hegemony, this study analyzes data collected through observations of Reyog performances at both festival and obyokan events, as well as interviews with artists and community members. The findings reveal that the obyokan model emphasizes an egalitarian spirit, allowing artists greater aesthetic freedom and providing the community with …
Preface Vol. 14 No. 3 (Desember), Rahayu Surtiati
Preface Vol. 14 No. 3 (Desember), Rahayu Surtiati
Paradigma: Jurnal Kajian Budaya
In the December 2024 edition, Paradigma presents ten articles covering four regions: Surakarta, Southeast Sulawesi, Minangkabau, Ponorogo; and also areas: cinema, dance, language, fashion, and education. All research are about cultures in Indonesia and written by Indonesian researchers.
This open journal is read by the international public, so we hope that humanities researchers in various regions of the world will participate with their writing, not only reporting research in Indonesia, but also research in other regions of the world. Paradigma is preparing to become an international journal and in time its triannual publications will be in English so that more …
Pancasila As The Philosophical Foundation Of The Indonesian Curriculum, Nurbaya Pulhehe, Babang Robandi
Pancasila As The Philosophical Foundation Of The Indonesian Curriculum, Nurbaya Pulhehe, Babang Robandi
Paradigma: Jurnal Kajian Budaya
The philosophical foundation of Pancasila, comprised of five principles, plays a significant role in shaping Indonesia's education system. These principles guide curriculum design, implementation, and evaluation, reflecting the nation's educational goals and desired student outcomes. This paper examines the philosophical underpinnings of Pancasila, with a focus on content and graduate competence standards, examining their relationship with educational objectives and their implications for the national curriculum. Utilizing a literature review methodology, the research highlights the critical influence of Pancasila on curriculum development and educational planning in Indonesia. The findings indicate that Pancasila serves as a central philosophical framework guiding Indonesia's national …
Symbolic Cultural Value: Creativity And Counterproductivity In Citayam Fashion Week 2022 In Indonesia, Fuad Noorzeha, Agus Sutono, John Abraham Ziswan Suryosumunar
Symbolic Cultural Value: Creativity And Counterproductivity In Citayam Fashion Week 2022 In Indonesia, Fuad Noorzeha, Agus Sutono, John Abraham Ziswan Suryosumunar
Paradigma: Jurnal Kajian Budaya
The phenomenon of Citayam Fashion Week has symbolically influenced the way lower-class youth dress in central Jakarta. What was once an urban area in Sudirman has transformed into a fashion arena after videos of young people sporting distinctive clothing styles went viral. More than just a social gathering, this occurrence has attracted significant attention on social media, showcasing unique fashion expressions. However, this spontaneous and instantaneous trend has sparked a wide range of responses, with opinions varying from viewing it as a creative expression to considering it counterproductive. This study employs Jean Baudrillard’s theory as its formal framework in qualitative …
Metakaolin-Based Geopolymer Concrete; Synthesis, Development And Characterization, Heba Fouad
Metakaolin-Based Geopolymer Concrete; Synthesis, Development And Characterization, Heba Fouad
Theses and Dissertations
Geopolymers are rendered as an essential sustainable replacement to the widely used Ordinary Portland Cement (OPC) which causes immense carbon dioxide emissions, hence a detrimental impact on society’s health and the environment. Geopolymers are three-dimensional networks of polymerized tetrahedral silicate and aluminate in the form of Q4(4Al), Q4(3Al) and Q4(2Al) which act as the principal binding phase in concrete. Past research has reported the synthesis of geopolymers from different aluminosilicates precursors, their characterization, and their wide range properties. However, previous studies still have not properly investigated effective range of synthesis ratios for a particular source material, optimum curing regimes, short- …
Understanding Women, Infant And Children Feeding Decisions In Emergencies: The Case Of Covid-19 And The Formula Shortage, Davida Mensah, Edmund F. Agyemang, Constance Gewa
Understanding Women, Infant And Children Feeding Decisions In Emergencies: The Case Of Covid-19 And The Formula Shortage, Davida Mensah, Edmund F. Agyemang, Constance Gewa
School of Mathematical & Statistical Sciences Faculty Publications
Background: The advantages of breastfeeding and its role in emergencies are undeniable. Studies show that many women in developed countries choose formula over breastmilk, even in emergencies. Nevertheless, no one knows if postpartum women under the Women, Infants and Children (WIC) program turned out to breastfeed or re-lactate their infants during these crises. This study aims to better understand WIC participants' perceptions about breastfeeding their babies in emergencies.
Methods: A chi-square test of independence was used to assess the association between breastfeeding choice and demographic characteristics and potential covariates of respondents. A post hoc analysis using Dunn's multiple comparisons test …
Assessment Of Implementation And Enforcement Of Smoke-Free Laws And Policies Among Malaysian Smokers: A Mixed Method Approach, Gan Shiz Yee
Assessment Of Implementation And Enforcement Of Smoke-Free Laws And Policies Among Malaysian Smokers: A Mixed Method Approach, Gan Shiz Yee
Student Works (2020-2029)
Smokefree laws (SFL) and policies could deter smoking by strengthening anti-smoking norms, impacting cessation behaviour due to decreased social acceptability of smoking in public spaces. With socioeconomic status (SES) affecting smoking risk factors, disparities in health outcomes post-SFL implementation are likely. Furthermore, regional and international assessments show Malaysia’s poor performance due to ineffective smoking bans and enforcement. Local studies revealed inadequate SFL implementation and enforcement, leading to high secondhand smoke (SHS) exposure. Understanding these challenges and opportunities is crucial for improving policy implementation and enforcement to enhance public health outcomes. This study examined the association between SFL and quit intention …
The Impact Of The University Education (Research) Index On The Global Competitiveness Of The United Arab Emirates During The Period (2021-2022), Dr. Shawk Hasan Mahdi
The Impact Of The University Education (Research) Index On The Global Competitiveness Of The United Arab Emirates During The Period (2021-2022), Dr. Shawk Hasan Mahdi
Faculty Peer-Reviewed Papers | بحوث هيئة التدريس المحكمة
This study aimed to demonstrate the relationship of the university education index (research) to the global competitiveness of the United Arab Emirates. The study relied on the quantitative approach to data analysis. The study sample consisted of a group of (manager, executive director, head of department/division, employee) who work in the departments, departments and offices of quality management and academic accreditation in accredited higher education institutions, the sample size was (360) individuals. The sample size was calculated to find the number of its individuals based on the equation for determining the size of the statistical sample for an unknown statistical …
Hiding In Plain Sight: Eating Disorders In Diverse Populations - A Case For Comprehensive Medical Education, Tashalee R Brown, Madeline O Jansen, Drew Hirsch, Habiba Amir, Alexis E Duncan, Ginger E Nicol
Hiding In Plain Sight: Eating Disorders In Diverse Populations - A Case For Comprehensive Medical Education, Tashalee R Brown, Madeline O Jansen, Drew Hirsch, Habiba Amir, Alexis E Duncan, Ginger E Nicol
2020-Current year OA Pubs
BACKGROUND: Training gaps regarding the diagnosis and management of eating disorders in diverse populations, including racial, ethnic, sexual, and gender minoritized groups, have not been thoroughly examined.
OBJECTIVE: This study aimed to examine resident physicians' knowledge and attitudes regarding eating disorders in diverse populations, with a focus on areas for improved training and intervention.
METHODS: Ninety-two resident physicians in internal medicine, emergency medicine, obstetrics/gynecology, psychiatry, and surgery at an academic center completed an online survey from 12/1/2020-3/1/2021, which comprised multiple choice and vignette-style open-ended questions to assess knowledge and attitudes toward the management and clinical presentations of eating disorders. Overall, …
Approaches And Outcomes Of Adalimumab Discontinuation In Patients With Well-Controlled Inflammatory Arthritis: A Systematic Search And Review, Erin Balay-Dustrude, Jessica Fennell, Kevin Baszis, Y Ingrid Goh, Daniel B Horton, Tzielan Lee, Chloe Rotman, Anna Sutton, Marinka Twilt, Olha Halyabar, Carra Jia Inactive Disease Workgroup
Approaches And Outcomes Of Adalimumab Discontinuation In Patients With Well-Controlled Inflammatory Arthritis: A Systematic Search And Review, Erin Balay-Dustrude, Jessica Fennell, Kevin Baszis, Y Ingrid Goh, Daniel B Horton, Tzielan Lee, Chloe Rotman, Anna Sutton, Marinka Twilt, Olha Halyabar, Carra Jia Inactive Disease Workgroup
2020-Current year OA Pubs
OBJECTIVE: This systematic search and review aimed to evaluate the available literature on discontinuation of adalimumab and other tumor necrosis factor inhibitors (TNFi) for patients with well-controlled chronic inflammatory arthritides.
METHODS: We conducted a publication search on adalimumab discontinuation from 2000-2023 using PubMed, CINAHL, EMBASE, and Cochrane Library. Included studies evaluated adalimumab discontinuation approaches, tapering schemes, and outcomes including successful discontinuation and recapture after flare, in patients with well-controlled disease. Studies included evaluated rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and juvenile idiopathic arthritis (JIA).
RESULTS: Forty-nine studies were included. Studies evaluating adalimumab alone were limited, and many reported TNFi outcomes …
Designing And Manufacturing Low-Cost, Tendon-Driven Soft Robots, Ted Winter-Glasgow, Pablo Borja
Designing And Manufacturing Low-Cost, Tendon-Driven Soft Robots, Ted Winter-Glasgow, Pablo Borja
School of Engineering, Computing and Mathematics
Soft robots have the potential to solve many problems in areas like robotics surgery, human-robot interaction, unmanned exploration tasks, and food harvesting. However, several aspects of soft robotics are still in development, e.g., efficient designs, actuation methods, modeling, and control. This paper provides some designs of tendon-driven soft robots that can be used for educational and research purposes, boosting the understanding of these systems. The proposed designs focus on five features: low manufacturing costs, accessible fabrication methods, simple assembly processes, an open-source approach, and durability.
Biphasic Models Improved S-Metolachlor Dissipation Endpoint Predictions, K. Badou-Jeremie Kouame, Mary Savin, Cammy Willett, Thomas R. Butts, Erin Grantz, Matthew Bertucci, Samantha E. Robinson, Rodrigo Werle, Nilda Roma-Burgos
Biphasic Models Improved S-Metolachlor Dissipation Endpoint Predictions, K. Badou-Jeremie Kouame, Mary Savin, Cammy Willett, Thomas R. Butts, Erin Grantz, Matthew Bertucci, Samantha E. Robinson, Rodrigo Werle, Nilda Roma-Burgos
Crop, Soil and Environmental Sciences Faculty Publications and Presentations
Accurate predictions of herbicide dissipation endpoints are essential for making environmental management decisions, estimating the duration of weed control, and deciding crop replant and rotation options. The performance of the single first-order (SFO), first-order multiple-compartment (FOMC), bi-exponential (BEXP), first-order double-exponential decay (FODED), and first-order two-compartment (FOTC) was evaluated to describe S-metolachlor dissipation. Results showed that the BEXP and FOTC were not appropriate. The FODED was ranked as the top model with the lowest Akaike's information criterion (AICc) value among the other three candidate models and was followed by the FOMC model. The SFO displayed the largest root mean square …
Nos Inhibition Sensitizes Metaplastic Breast Cancer To Pi3k Inhibition And Taxane Therapy Via C-Jun Repression, Tejaswini Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas, Wei Qian, Hong Zhao, Adrian Oo, Young-Jae Cho, Baek Kim, Jose Thaiparambil, Roberto Rosato, Karina Ortega Martinez, Maria Florencia Chervo, Camila Ayerbe, Noah Giese, David Wink, Stephen Lockett, Stephen Wong, Jeffrey Chang, Savitri Krishnamurthy, Clinton Yam, Stacy Moulder, Helen Piwnica-Worms, Funda Meric-Bernstam, Jenny Chang
Nos Inhibition Sensitizes Metaplastic Breast Cancer To Pi3k Inhibition And Taxane Therapy Via C-Jun Repression, Tejaswini Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas, Wei Qian, Hong Zhao, Adrian Oo, Young-Jae Cho, Baek Kim, Jose Thaiparambil, Roberto Rosato, Karina Ortega Martinez, Maria Florencia Chervo, Camila Ayerbe, Noah Giese, David Wink, Stephen Lockett, Stephen Wong, Jeffrey Chang, Savitri Krishnamurthy, Clinton Yam, Stacy Moulder, Helen Piwnica-Worms, Funda Meric-Bernstam, Jenny Chang
Faculty, Staff and Student Publications
Metaplastic breast cancer (MpBC) is a highly chemoresistant subtype of breast cancer with no standardized therapy options. A clinical study in anthracycline-refractory MpBC patients suggested that nitric oxide synthase (NOS) inhibitor NG-monomethyl-l-arginine (L-NMMA) may augment anti-tumor efficacy of taxane. We report that NOS blockade potentiated response of human MpBC cell lines and tumors to phosphoinositide 3-kinase (PI3K) inhibitor alpelisib and taxane. Mechanistically, NOS blockade leads to a decrease in the S-nitrosylation of c-Jun NH
Double-Blind Randomised Trial Of Saline Solution For Gargling And Nasal Rinsing In Sars-Cov-2 Infection, Andres Espinoza
Double-Blind Randomised Trial Of Saline Solution For Gargling And Nasal Rinsing In Sars-Cov-2 Infection, Andres Espinoza
Faculty, Staff and Student Publications
Background: Previous studies have shown that hypertonic saline nasal irrigation and gargling reduced the duration of symptoms in upper respiratory infections caused by coronavirus. This study aims to investigate the effects of two saline regimens on symptoms associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Methods: Between 2020 and 2022, individuals aged 18-65 years who tested positive for SARS-CoV-2 infection via polymerase chain reaction (PCR) were randomly assigned to either low- or high-saline regimens for 14 days. The low-saline solutions contained 2.13 g of salt dissolved in eight ounces of warm water, while the high-saline solution contained six grams of …
Exploring Proteins Within The Coccolith Matrix, Craig J. Dedman, Nishant Chauhan, Alba González-Lanchas, Chloë Baldreki, Adam A. Dowle, Tony R. Larson, Renee B.Y. Lee, Rosalind E.M. Rickaby
Exploring Proteins Within The Coccolith Matrix, Craig J. Dedman, Nishant Chauhan, Alba González-Lanchas, Chloë Baldreki, Adam A. Dowle, Tony R. Larson, Renee B.Y. Lee, Rosalind E.M. Rickaby
School of Geography, Earth and Environmental Sciences
Coccolithophores comprise a major component of the oceanic carbon cycle. These unicellular algae produce ornate structures made of calcium carbonate, termed coccoliths, representing ~ 50% of calcite production in the open ocean. The exact molecular mechanisms which direct and control coccolith formation are unknown. In this study, we report on the presence and functional features of proteins within the coccoliths produced by a range of model coccolithophore species including: the globally abundant and well-studied Gephyrocapsa huxleyi (formerly Emiliania huxleyi) and related Gephyrocapsa oceanica, as well as the larger and more heavily calcified Coccolithus braarudii. Protein features were compared between species …
Dlk-Dependent Axonal Mitochondrial Fission Drives Degeneration After Axotomy, Francisco M Nadal-Nicolás, Preethi Somasundaram, Anastasia L Slavutsky, Wei Li, Michael E Ward, Trent A Watkins, Claire E Le Pichon
Dlk-Dependent Axonal Mitochondrial Fission Drives Degeneration After Axotomy, Francisco M Nadal-Nicolás, Preethi Somasundaram, Anastasia L Slavutsky, Wei Li, Michael E Ward, Trent A Watkins, Claire E Le Pichon
Faculty, Staff and Students Publications
Currently there are no effective treatments for an array of neurodegenerative disorders to a large part because cell-based models fail to recapitulate disease. Here we develop a reproducible human iPSC-based model where laser axotomy causes retrograde axon degeneration leading to neuronal cell death. Time-lapse confocal imaging revealed that damage triggers an apoptotic wave of mitochondrial fission proceeding from the site of injury to the soma. We demonstrate that this apoptotic wave is locally initiated in the axon by dual leucine zipper kinase (DLK). We find that mitochondrial fission and resultant cell death are entirely dependent on phosphorylation of dynamin related …