Digital Commons Network^™

Small Molecule Screening Identifies Hsp90 As A Modifier Of Rna Foci In Myotonic Dystrophy Type 1, Clifford Stephan, Fabio Stossi, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic dystrophy type 1 (DM1) is a multisystemic disorder caused by a CTG triplet repeat expansion within the 3' untranslated region of the DMPK gene. Expression of the expanded allele generates RNA containing long tracts of CUG repeats (CUGexp RNA) that form hairpin structures and accumulate in nuclear RNA foci; however, the factors that control DMPK expression and the formation of CUGexp RNA foci remain largely unknown. We performed an unbiased small molecule screen in an immortalized human DM1 skeletal muscle myoblast cell line and identified HSP90 as a modifier of endogenous RNA foci. Small molecule inhibition of HSP90 leads …

Zero-Inflated Models For The Evaluation Of Colorectal Polyps In Colon Cancer Screening Studies-A Value-Based Biostatistics Practice, Marc J Zuckerman

Faculty, Staff and Students Publications

Background: Colon cancer screening studies are needed for the early detection of colorectal polyps to reduce the risk of colorectal cancer. Unfortunately, the data generated on colon polyps are typically analyzed in their dichotomized form and sometimes with standard count models, which leads to potentially inaccurate findings in research studies. A more appropriate approach for evaluating colon polyps is zero-inflated models, considering undetected existing polyps at colonoscopy screening.

Method: We demonstrated the application of the zero-inflated and hurdle models including zero-inflated Poisson (ZIP), zero-inflated robust Poisson (ZIRP), zero-inflated negative binomial (ZINB), zero-inflated generalized Poisson (ZIGP), zero hurdle Poisson (ZHP), and …

Effects Of Dialysate Potassium Concentration Of 30 Mmol/Leffects Of Dialysate Potassium Concentration Of 30 Mmol/L With Sodium Zirconium Cyclosilicate On Dialysis-Free Days Versus Dialysate Potassium Concentration Of 20 Mmol/L Alone On Rates Of Cardiac With Sodium Zirconium Cyclosilicate On Dialysis-Free Days Versus Dialysate Potassium Concentration Of 20 Mmol/L Alone On Rates Of Cardiac Arrhythmias In Hemodialysis Patients With Hyperkalemia Arrhythmias In Hemodialysis Patients With Hyperkalemia, John P Middleton, Charles A Herzog, Glenn M Chertow, James M Eudicone, Jeremy D Whitson, James A Tumlin

Faculty, Staff and Students Publications

The optimal approach towards managing serum potassium (sK+) and hemodialysate potassium concentrations is uncertain. To study this, adults receiving hemodialysis for three months or more with hyperkalemia (pre-dialysis sK+ 5.1-6.5 mmol/l) had cardiac monitors implanted and were randomized to either eight weeks of 2.0 mmol/l potassium/1.25 mmol/l calcium dialysate without sodium zirconium cyclosilicate (SZC) (2.0 potassium/noSZC) or 3.0 mmol/l potassium/1.25 mmol/l calcium dialysate combined with SZC (3.0 potassium/SZC) on non-dialysis days to maintain pre-dialysis sK+ 4.0-5.5 mmol/l, followed by treatment crossover for another eight weeks. The primary outcome was the rate of adjudicated atrial fibrillation (AF) episodes of at least …

Percutaneous Stenting As Treatment For Chylothorax From Superior Vena Cava Syndrome: A Case Report, David Wynne, David Léon

Faculty, Staff and Students Publications

Superior vena cava syndrome is a condition that results from obstruction of the superior vena cava, the etiology of which can be benign or malignant. The impaired venous return can cause facial and upper extremity swelling, dyspnea, and neurologic symptoms. Chylothorax is a rare complication of superior vena cava syndrome. We report a case of a 69-year-old male with end-stage renal disease, who developed both a chylothorax and a contralateral simple pleural effusion secondary to superior vena cava syndrome. He was successfully treated with percutaneous endovascular stenting.

Increasing Surgical Healthcare Utilization For Infants With Congenital Anomalies In Texas, Kathleen Hosek, Dailen Alonso, Timothy C Lee, Sundeep G Keswani, Alice King

Faculty, Staff and Students Publications

Introduction: Congenital anomalies (CAs) impact 3% of live births and account for disproportionately high healthcare costs. While many CAs require multidisciplinary care and surgical intervention, the overall financial impact of infants diagnosed with CA with surgical needs is unknown. We aim to evaluate and characterize the charges of care in infants with CA and surgical needs in Texas.

Methods: A database study using the Texas Inpatient Public Use Data File was performed to query infants (< 365 days) statewide from 1/2021 to 12/2021 for admissions with CA and involved organ system by ICD-10 codes. Encounters transferred to an outside hospital were excluded to avoid systematic double-counting. Descriptive statistics were performed.

Results: Of 376,215 total admissions, 81,666 had surgical needs with OR charges. While non-CA represent the majority of surgical admissions (63,895/81,666; 78.24%), CA-surgical admissions …

The Caseload Chronicles: Investigating The Case Manager Role Through The Perspectives Of Current Special Education Teachers, Khalil Milad Abouhamad

University of the Pacific Theses and Dissertations

Teacher attrition and resulting shortages have become severely problematic across the United States. This is especially true within special education. This study employs role theory (Kahn et al., 1964) to isolate the case manager role carried by special education teachers, investigate it through the stories of current practitioners, and establish it within academia. Burnout theory (Maslach, 1993) provides a lens through which to evaluate the strain of working conditions surrounding the case manager role. Elements of narrative inquiry (Clandinin, 2006; Creswell & Guetterman, 2019) in the form of 1-1 interviews with current IEP case managers from across California provided the …

Understanding Institutional Factors That Hinder Black Students’ Ability To Persist At Community Colleges, Tadael Emiru

University of the Pacific Theses and Dissertations

Community colleges face a significant challenge with high attrition rates, which disproportionately impact Black students compared to other student groups. Hope Community Colleges reflect this trend, with a notable percentage of students dropping out before achieving their academic goals. The implications of this high dropout rate extend beyond individual students, affecting the local, state, and national economies.

Although existing research primarily focuses on students’ personal characteristics that influence their ability to stay in college, there is a noticeable gap in understanding the institutional factors that negatively affect student persistence, particularly for Black students in community colleges. This study sought to …

Heading For The Hills: An Evaluation Of The Conditions Impacting Teacher Attrition And Retention In Post-Pandemic California Title I Schools, Colin M. Mcinnis

University of the Pacific Theses and Dissertations

The low rates of preservice and early in-service teacher retention in California’s Title I schools have been a longstanding concern and contributing factor in the state’s teacher shortage. However, the impacts of the SARS-CoV-2 (Coronavirus) pandemic exacerbating teacher attrition creates a concern for how frameworks of new teacher support should be re-examined in post-pandemic classrooms. This study aimed to understand what factors are most important to preservice and early in-service teachers working in Title I schools when deciding to retain or resign from their positions. Additionally, this study examined whether reported factors associated with teacher attrition and retention differ from …

Professional School Alumni Donor Motivations For Making Charitable Bequest Gifts To Their Alma Mater, James A. Dugoni Edd

University of the Pacific Theses and Dissertations

Professional School Alumni Donor Motivations for Making Charitable Bequest Gifts to Their Alma Mater

Abstract

By James A. Dugoni

University of the Pacific 2025

This study explored the reasons University of the Pacific (UOP) professional school alumni in the fields of dentistry, law, and pharmacy have chosen to make charitable bequest gifts to their alma mater. The study looked at their student, alumni, and donor experiences to determine the factors that motivated them to leave a charitable bequest gift. The study further analyzed how social exchange theory can explain their planned giving behaviors. This study contributes to the body of …

Understanding Self-Efficacy And Motivation In Elementary Teachers: The Influence And Support Of School Administrators, Maria Vigil

University of the Pacific Theses and Dissertations

Teachers’ attrition is commonly seen within the first five years in the profession. Various reasons exist as the cause for this decision including: low pay rates, lack of support and stress. With the important role educators hold, a clear understanding of their specific needs can help strengthen their abilities while remaining in the field. The purpose of this mixed methods study was to understand teachers’ perspectives of what influences their self-efficacy and motivation in order to promote strong work performance, effectiveness, increase teacher satisfaction and retention rates while highlighting the impact of support provided by school administrators. The research questions …

Engaging The Plus-Size Community Through Social Media And Public Relations, Esperanza Chavez

University of the Pacific Theses and Dissertations

This thesis explores which platform, TikTok or Instagram, best supports engagement andcommunity building for the plus-size audience. Grounded in theories by Goffman, Berger & Luckmann, and David Meerman Scott’s 85-10-5 Rule, the study combines strategic PR methods with digital media tools to elevate plus-size voices. The campaign included 30 Instagram posts, 35 TikToks, street interviews, and a podcast series, all designed and executed for this project. Engagement was measured through likes, comments, shares, saves, follower growth, and qualitative audience feedback.

Effects Of Cross-Sex Hormone Therapy (Csht) On Aortic Reactivity And Metabolic Parameters In Gonadectomized Male And Female Rats, Rifat Ara Islam

University of the Pacific Theses and Dissertations

With the rising awareness, the number of individuals identifying themselves as transgender in the US is increasing over the years. Cross-sex hormone therapy (CSHT) may alter cardiometabolic parameters leading to the increased risk of cardiovascular diseases (CVD) in transgender population. However, the underlying mechanisms of impaired cardiovascular functions in transgender female (male to female, MtF) or transgender male (female to male, FtM) individuals are not well documented. This study was undertaken to examine the effects of 17β-estradiol (E2)- and testosterone propionate (Tes)-treatment on key cardiometabolic parameters and aortic reactivity in castrated (CAS) male and ovariectomized (OVX) female Sprague Dawley (SD) …

Knocking On Resistance’S Door: Investigating The Spread And Drivers Of Kdr Mutations In Northern California Culex Tarsalis, Esther Blankenship-Cutshall

University of the Pacific Theses and Dissertations

Vector-borne diseases are an increasingly relevant threat to public health as climate change alters the ecology of vector populations in relation to humans. One key to combating vector-borne disease is using pyrethroid insecticides against mosquito populations. However, wild mosquito populations have exhibited resistance to those key pyrethroids. One resistance mechanism under investigation is the altering of the voltage-gated sodium channel, which is associated with the genetic mutations known as kdr. The prevalence and history of kdr mutations has been investigated in some populations of Culex pipiens, however, it is unknown in northern California Culex tarsalis populations. This study aims to …

Student Perceptions Of Campus Facilities And Their Impact On Educational Experience, Steven W. Greenwood

University of the Pacific Theses and Dissertations

This dissertation investigates the perceptions of undergraduate students regarding campus facilities at a picturesque academic institution located in Northern California and explores how these perceptions impact their educational experiences and outcomes. Despite the significant role of physical and technological infrastructure in shaping educational environments, student voices are often underrepresented in the capital renewal process. This study aims to fill this gap by employing a qualitative research approach grounded in empowerment theory and using participatory methods, such as photovoice and semistructured interviews. It underscores the importance of student involvement in facility planning and renewal processes and introduces the research objectives, theoretical …

Narrative Inquiry Into The Socio Economic Integration And Resilience Of The Mien Community In The United States, Teresa M. Saefong

University of the Pacific Theses and Dissertations

This qualitative study examined the socioeconomic integration of the Mien community, a refugee minority sometimes overlooked in research and policy discussions, in the United States. Five participants shared their experiences through in-depth interviews and community observations. The study utilizes narrative inquiry and is informed by community cultural wealth and resilience theory. The analysis incorporated restorying, comparative, and performative approaches. The findings suggested that Mien integration depended on intergenerational storytelling, clan-based networks, multilingual skills, and the adaption of traditional practices within U.S. institutions. Community organizations were important for keeping culture alive and filling in the gaps in institutional services by giving …

A Look Into A Great Coach: Qualitative Study Of Post-Game Talks Of A Highly Successful Volleyball Collegiate Coach, Daniel Nobuo Llarenas

University of the Pacific Theses and Dissertations

The primary purpose of this study was to explore the post-game talks of a highly successful collegiate coach. A total of 19 post game talks were audio recorded during the 2012 championship season of the University of California Irvine (UCI) Men’s Volleyball team. Coach John Speraw; an American Caucasian Division I Men’s Collegiate Volleyball coach and was the Head coach during the 2012 season. Post game talks were recorded with intentions of assessing content and transcribed verbatim with the average length of each talk was 7 minutes and 23 seconds (4:36 – 23:04 mins). Analyses of the transcripts revealed 2 …

Examining Mental Health Providers’ Differential Sensitivity To Youth And Caregiver Treatment Engagement Problems By Studying Clinical Decision-Making Behaviors, Wendy Chu

Theses and Dissertations

Clinical decision-making is a systematic process of collecting and using information to guide action regarding client care. Across frameworks of clinical decision-making, there is an emphasis on the assessment of a problem – which involves considering, identifying, and selecting a problem – as it directly informs intervention. In youth mental health services, problems related to treatment engagement or the ability to meaningfully participate in services are important to assess given their association with premature termination and poor outcomes. However, research suggests that assessment of engagement problems may be challenging, and one potential reason pertains to providers’ ability to assess across …

Integrating School Mental Health Services: How Therapeutic Alliance May Improve Outcomes In A Mental Health Literacy Intervention, Alena Quinn

Theses and Dissertations

The youth mental health crisis continues to face persistent barriers of stigma, workforce shortages, and fragmented service delivery systems. Schools play a pivotal role in addressing these challenges, as youth are six times more likely to access mental health services in schools than in community settings. Frameworks such as the Comprehensive School Mental Health Systems (CSMHS) and the Interconnected Systems Framework (ISF) have improved access and quality of school-based mental health services through integration and partnership efforts. However, stigma remains a persistent barrier for seeking help and perpetuating untreated mental health difficulties. Research has found that mental health literacy (MHL) …

Invention Beyond The Author, Jonathan Brent Butler

Theses and Dissertations

The following dissertation examines how what Michel Foucault calls the “author function” affects contemporary students of writing and examines some historical alternatives to this way of conceptualizing the writing process and the writer’s role in it. Chapter 1: Author (Dys)function describes the author function and its discontents, the problems of the Romantic conception of “genius,” and summarizes the following chapters. Chapter 2: Early Writing Instruction focuses on classical approaches to rhetorical instruction that emphasize habit and aim at the cultivation of a particular subjectivity characterized by the capacity to respond to shifting rhetorical situations; this chapter draws on the work …

Emotions And Cognition, Krystal D. Becks

Theses and Dissertations

Background: Cognitive functioning is linked to emotional processes, with this relationship shaped by various biological (e.g., age, sex, diseases, and genetics), psychological (e.g., emotional well-being, coping strategies, mental health), and sociological (e.g., income and education) factors. Understanding these interactions is critical for advancing research on cognitive-emotional health across diverse populations. Purpose: To examine the relationship between positive and negative emotions and cognitive functioning among healthy adults. Methods: This was a cross-sectional analysis of data from the Aging Brain Cohort (ABC) study (n=434). The independent variables were subsets from the NIH toolbox emotional battery. The dependent variables were from the NIH …

Intimate Partner Violence Victims' Experiences With Civil Legal Interventions, Jessica Brooke Pomerantz

Theses and Dissertations

The court system has become a central part of the societal response to intimate partner violence (IPV) and is a frequently used as a source of help for victims (Cattaneo et al., 2013). Despite the importance of a justice system response to IPV, it is not always accessible or helpful to victims. Past research has demonstrated barriers to IPV victims seeking legal intervention including mistrust of the court system generally, extensive and confusing legal processes and procedures, and failure of the courts to assess more invisible forms of abuse (Calton et al., 2017; Cerulli et al., 2015; Cuomo & Dolci, …

Iq Trends In Preschoolers With Autism And Co-Occurring Developmental Delay Are Associated With Autism Severity Not Anxiety, Chandler Elizabeth Knott

Theses and Dissertations

Intellectual functioning constitutes a significant source of heterogeneity in individuals with autism spectrum disorder (ASD); however, little is known about how intellectual functioning manifests over development in preschool children with non-syndromic ASD (nsASD) and co-occurring global developmental delay (GDD) or how this relates to functionally impairing co-occurring conditions, such as anxiety. Study participants included 57 children with nsASD and co-occurring global developmental delay (ASD+GDD), 24 categorized with mild GDD, and 33 categorized with moderate GDD. Drawing on dynamic systems theory, the present study explored developmental trends within the context of multiple complex systems, including intelligence, social-emotional, and behavioral functioning. Moderated …

Social Support And Gratitude In Adolescents: An Exploratory Study, Mimi Webb Kurtz

Theses and Dissertations

Dispositional gratitude is a construct associated with numerous benefits in youth. However, existing research has primarily focused on the outcomes of gratitude, with limited exploration of the underlying factors that may contribute to individual differences in its development. Because gratitude is considered malleable, identifying key factors associated with its growth in youth is essential. The present study aims to address this gap by exploring perceived social support as a presumed antecedent of dispositional gratitude in older adolescents. Cross-sectional, self-report data and structural equation modeling were used to assess the relationship of perceived social support with gratitude levels among high school …

Self-Regulation In Children With Fragile X Syndrome: Biobehavioral Underpinnings, Familial Predictors, And Outcomes, Erin Evelyn Hunt

Theses and Dissertations

Self-regulation is a multifaceted construct that occurs on biological, cognitive, emotional, and behavioral levels. Self-regulatory abilities typically emerge in the first years of life and continuously develop through early adulthood. There is considerable interindividual variability in developmental trajectories of self-regulation which are associated with numerous adaptive and maladaptive outcomes. Factors influencing the development of self-regulation include interacting genetic and social environmental factors. Given the high heritability of self-regulation, within-family associations are common.

Individuals with Fragile X syndrome (FXS), an inherited, single-gene neurodevelopmental disorder, have heightened vulnerability for self-regulation deficits that are evident in early infancy; however, the developmental trajectories and …

Examining Effects Of A Cultural And Family Resilience Program On Improving Physical Activity And Eating Behaviors Among Overweight Black Adolescents, Mary Quattlebaum

Theses and Dissertations

Black adolescents have higher rates of physical inactivity, lower quality dietary intake, and fewer family meals compared to their White peers. These health inequities place Black adolescents at greater risk for overweight and obesity, as well as long-term health consequences, including chronic disease and early mortality. However, few health promotion programs have been successful in improving health behaviors among Black adolescents and families. Elevated rates of chronic stress, namely racial stress, among Black families may be a prominent obstacle for engagement in and effectiveness of health promotion initiatives. Limited family-based health promotion programs with Black families have incorporated cultural and …

Choice Overload In The Digital Age: A Cognitive Neuroscience Approach, Jacob Matthew Stanley

Theses and Dissertations

This dissertation examines the neural mechanisms of value-based multiattribute decision making through the lens of choice overload during consumer choice. Two behavioral experiments established that choice sets of a moderate size with nine options were perceived as most optimal compared to choice sets with three and 24 options, and options chosen from the largest set size were judged to be the least satisfying. A functional MRI study then examined how the brain responds to choice sets varying in size and complexity by manipulating the number of options presented as well as the presence of asymmetrically dominated decoy alternatives during a …

A Math Teacher’S Reflexive Journey Into The Opportunity Gap, Richard A. Ball Iii

Theses and Dissertations

This multiple case study sought to determine what educational factors, if any, impacted Black students in a public school located in the South-eastern United States, to enroll in a lower-level math course. The study also aimed to view the mathematical identities of these students and have myself reflect on my practice both locally and globally. This, however, is a result of the Problem of Practice, the opportunity gap. H. Richard Milner’s (2012) opportunity gap framework served as the theoretical framework for this study and for which all findings were situated. The data was analyzed using deductive coding, with the elements …

Examining The Distribution And Predictability Of Population Dynamics Across Geographic Space, Cleber Ten Caten

Theses and Dissertations

Populations occupy different regions of the geographic space and may experience distinct conditions over time that can cause fluctuations in their number of individuals. Environmental conditions, dispersal events, and resource availability are some of the factors that influence populations. A central goal in ecology has been to develop generalizations about how these factors that affect population dynamics are structured in geographic space. However, limited knowledge about where species occur and a lack of long-term surveys of populations has hindered the development, and validation, of such generalizations. In this dissertation, I use a combination of observational data, simulations, and experimental approaches …

Modeling Functional Connectivity With Learning And Memory In A Mouse Model Of Alzheimer’S Disease, Jonathan Romero, Caitlyn Ortiz, Eric Shin, Md Abul Hassan Samee, Robia G Pautler

Faculty, Staff and Students Publications

Introduction: Functional connectivity (FC) is a metric of how different brain regions interact with each other. Although there have been some studies correlating learning and memory with FC, there have not yet been, to date, studies that use machine learning (ML) to explain how FC changes can be used to explain behavior not only in healthy mice, but also in mouse models of Alzheimer's Disease (AD). Here, we investigated changes in FC and their relationship to learning and memory in a mouse model of AD across disease progression.

Methods: We assessed the APP/PS1 mouse model of AD and wild-type controls …

Self-Perceived Importance And Confidence Of Adolescents Transitioning To Adult Care., Lisa Lestishock, Carrie Cuomo, Teresa Hickam, Tisa Johnson-Hooper, Michele H. Maddux, Evan Muzzall, Margaret Mcmanus, Patience White

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: Motivational interviewing (MI) techniques are used by health care teams to engage adolescents and young adults (AYAs) in health care self-management and pediatric to adult health care transition (HCT) planning efforts. The aim of this study was to assess the initial level of motivation of AYAs prior to receipt of HCT anticipatory guidance and to determine associations with demographic and health coverage factors.

METHODS: This retrospective study included 5112 AYAs, aged 12-26 years, from four health systems. All AYAs completed the Got Transition readiness assessment that includes MI questions on importance and confidence related to the move to an …