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Looking Beyond The Achievement Gap: An Inquiry Into Bridging The Divide Between Teacher Preparedness And English Learners’ Literacy Success, Sean Rhoads Jan 2025

Looking Beyond The Achievement Gap: An Inquiry Into Bridging The Divide Between Teacher Preparedness And English Learners’ Literacy Success, Sean Rhoads

Theses and Dissertations

English Learners (ELs) in early childhood and elementary settings continue to face a significant literacy achievement gap compared to their non-EL peers. A qualitative action research study was conducted in a suburban Midwest district to examine how teacher preparedness, instructional practices, and professional development influence EL literacy development. Through teacher interviews, surveys, and classroom observations, the study identified key challenges, including limited EL-specific training, minimal collaboration with EL specialists, and inadequate instructional resources. Aimsweb Plus data confirmed a widening literacy gap, reinforcing the need for culturally responsive teaching, improved collaboration, and targeted interventions. The findings emphasize the importance of sustained …


Uncertainty In Decision-Making Within The Dental Context Of Malaysia’S Multi-Ethnic Population – A Mixed-Methods Study, Prashanti Eachempati Jan 2025

Uncertainty In Decision-Making Within The Dental Context Of Malaysia’S Multi-Ethnic Population – A Mixed-Methods Study, Prashanti Eachempati

Peninsula Dental School Theses

Background:Uncertainty is an inherent part of healthcare, particularly in decision-making. Shared decision-making in many Asian contexts faces challenges due to language barriers, religious practices, hierarchical clinical norms, and collectivist approaches to decision-making. Under uncertain conditions, these challenges become even more complex and may be influenced by individuals’ tolerance of uncertainty. Understanding how both patients and dentists of multi-ethnolinguistic groups experience and respond to uncertainty is therefore essential to support context-sensitive, culturally responsive dental decision-making.Aim:To explore how multi-ethnic patients and dentists in Malaysia, with varying levels of uncertainty tolerance, perceive and respond to uncertainty in oral health decision-making, and how they …


A Multiethnic Approach Of Stakeholder Involvement To Set Priorities For Oral Health Research, Sumanth Kumbargere Nagraj Jan 2025

A Multiethnic Approach Of Stakeholder Involvement To Set Priorities For Oral Health Research, Sumanth Kumbargere Nagraj

Peninsula Dental School Theses

Setting research priorities is a key component of an effective research system. Stakeholder involvement, both formal and informal, is crucial in this process. Only few studies focus on the challenges of engaging diverse populations, particularly those from different ethnic and linguistic backgrounds, or how their values and priorities may align or differ.In Malaysia, a multiethnic and multilingual country, significant oral health disparities have been reported across ethnic groups. For example, the Malaysian National Oral Health Survey (2017) documented a higher prevalence of dental caries among Chinese children (30.7%), the highest oral cancer rates among Indians (46.2%), and the lowest prevalence …


Boys Build, Girls Glam: An Examination Of Adult Language Use In Informal Steam Education Settings, Alexandra Horton Jan 2025

Boys Build, Girls Glam: An Examination Of Adult Language Use In Informal Steam Education Settings, Alexandra Horton

Theses and Dissertations

Research on STEAM education has primarily focused on formal education settings such as schools, with more research needed in informal or non-traditional education settings. As children frequently engage with informal and non-traditional education settings, it is important to understand how we can transmit information in these settings to bolster and further the learning process and increase engagement. STEAM fields have been plagued by racial and gender inequities that have led to these groups being marginalized and excluded (Blair et al., 2017; Eaton et al., 2020; Martin, 2018; Martin & Phillips, 2019; Miller et al., 2018; Newall et al., 2018, Sheffield …


A Care-Focused Characterization Of Beginning Elementary Preservice Teachers’ Visions Of Mathematics Instruction, Alicia Marie Erwin Jan 2025

A Care-Focused Characterization Of Beginning Elementary Preservice Teachers’ Visions Of Mathematics Instruction, Alicia Marie Erwin

Theses and Dissertations

In this dissertation study, I sought to understand how elementary preservice teachers (EPTs) envisioned mathematics instruction at the beginning of their university program and what factors they identified as contributing to those visions. I conducted semi-structured interviews with 32 EPTs who had recently finished their first mathematics content course in their university program. I then connected theories of teacher care to characterize their visions of mathematical instruction.

Through my data analysis, I identified five themes that represented components of the EPTs’ beginning visions of mathematics instruction: Driver of the Math Task, Focus of the Math Task, Student Sharing, Classroom Environment, …


The Wellbeing Study: Exploring Healthcare Professionals (Hcps) Psychological Wellbeing At Work And Patients’ Experiences Of Care, Kathryn Bamforth Jan 2025

The Wellbeing Study: Exploring Healthcare Professionals (Hcps) Psychological Wellbeing At Work And Patients’ Experiences Of Care, Kathryn Bamforth

School of Nursing and Midwifery Theses

Kathryn Marie BamforthTitle: The WELLBEING Study: Exploring Healthcare Professionals (HCPs) Psychological Wellbeing at Work and Patients’ Experiences of CareBackground: HCPs’ psychological wellbeing affects patients’ experiences of care. The COVID-19 pandemic, cost of living and workforce crises have taken their toll on HCP wellbeing. There is scant evidence on HCPs’ perceptions of psychological wellbeing at work or how they could be better supported. There is less research that considers patients’ perspectives.Aim: To explore HCPs’ and patients’ perceptions of staff psychological wellbeing at work and use the first four stages of experience-based co-design (EBCD) to identify models of practice to support HCP …


Singapore’S Health Outcomes After Critical Illness In Kids: A Mixed-Methods Longitudinal Cohort Study To Explore Health Outcomes Of Children And Parents Six Months After Critical Illness, Pei Fen Poh Jan 2025

Singapore’S Health Outcomes After Critical Illness In Kids: A Mixed-Methods Longitudinal Cohort Study To Explore Health Outcomes Of Children And Parents Six Months After Critical Illness, Pei Fen Poh

School of Nursing and Midwifery Theses

Background: Post-Intensive Care Syndrome in paediatrics (PICS-p) encompasses physical, cognitive, social, and emotional health impairments in children, as well as psychological challenges in parents, following PICU discharge. While PICS is well-studied in adults, research on its long-term effects in the paediatric population is limited, and the influence of ethnicity remains unexplored.Aim: The aim of this study was to explore and understand the long-term health outcomes and experiences of children and their parents during the first six months following discharge from the paediatric intensive care unit (PICU), and to examine the influence of ethnicity. Methods: The SHACK study was informed by …


Neurally Adjusted Ventilatory Assist In Infants With Acute Viral Bronchiolitis (Navabronch Study) A Mixed Methods Feasibility Study To Establish The Evidence And To Evaluate The Effectiveness Of Neurally Adjusted Ventilatory Assist In Infants With Acute Viral Bronchiolitis, Julia Harris Jan 2025

Neurally Adjusted Ventilatory Assist In Infants With Acute Viral Bronchiolitis (Navabronch Study) A Mixed Methods Feasibility Study To Establish The Evidence And To Evaluate The Effectiveness Of Neurally Adjusted Ventilatory Assist In Infants With Acute Viral Bronchiolitis, Julia Harris

School of Nursing and Midwifery Theses

Julia HarrisNeurally Adjusted Ventilatory Assist in infants with acute viral bronchiolitis (NAVABronch study) - A mixed methods Feasibility study To establish the evidence and to evaluate the effectiveness of neurally adjusted ventilatory assist in infants with acute viral bronchiolitis. Abstract AimThe aim of this mixed-methods thesis is to evaluate the use of Neurally Adjusted Ventilatory Assist (NAVA) in infants with acute viral bronchiolitis. BackgroundThere are currently 6,662 infants less than one year of age with a primary respiratory diagnosis admitted to Paediatric Intensive Care Units (PICUs) in the UK each year. Respiratory illness is more common in winter, with the …


Language Ideologies In Coloniality Contexts: An Interpretive Phenomenological Analysis Of Efl Teachers’ Experiences And Perceptions On The Use Of Learners’ Language Repertoire As Assets For Teaching And Learning, Kountiala J. Some Jan 2025

Language Ideologies In Coloniality Contexts: An Interpretive Phenomenological Analysis Of Efl Teachers’ Experiences And Perceptions On The Use Of Learners’ Language Repertoire As Assets For Teaching And Learning, Kountiala J. Some

Theses and Dissertations

In this dissertation, I examined how dominant language ideologies in language politics and policy shape the professional identity development and pedagogical practices of five English as a Foreign Language (EFL) teachers in Burkina Faso. The study sought to understand how these ideologies influence teachers’ beliefs and perceptions of multilingual pedagogical approaches, as well as possible pathways for deconstructing them to promote student-centered practices. The participants’ accounts revealed that their academic and professional identities were largely shaped by the belief that home languages hinder proficiency in French and English. They recalled with remorse their elementary school experiences, where speaking native languages …


Machine Learning-Based Prediction Of Endometrial Cancer Prognosis, Sherif Shazly Jan 2025

Machine Learning-Based Prediction Of Endometrial Cancer Prognosis, Sherif Shazly

School of Nursing and Midwifery Theses

This thesis develops and uses machine learning tools to predict the prognosis of endometrial cancer. With endometrial cancer being the most common gynaecologic malignancy in low- and middle-income countries, accurate prognostic models are essential for improving patient outcomes. This research aims to develop and validate machine learning-based models to predict CSS (cancer-specific survival) and DFS (disease-free survival) at 3- and 5-year intervals, utilizing patient demographics, preoperative imaging, histopathological characteristics, and treatment data.The study employed multiple machine learning algorithms, including logistic regression, support vector machines, XGBoost, and random forest, to create three predictive models: a preoperative model, a management-based model, and …


Growing Through The Questions: Studying Sticking Points To Strengthen Commitments To Socially Just English Language Arts Teaching, Kaitlyn P. Blake Jan 2025

Growing Through The Questions: Studying Sticking Points To Strengthen Commitments To Socially Just English Language Arts Teaching, Kaitlyn P. Blake

Theses and Dissertations

This teacher-research study explores sticking points that emerge in my high school English language arts (ELA) classroom as a way of aligning my practice with my socially just ELA teaching framework, especially in my early career years. Using qualitative methods to focus on my classroom interactions with students, two specific sticking points emerged as significant to my learning. Although I initially interpreted these sticking points as being between the students and me, my analysis revealed that the sticking points were actually a result of my socially just framework being challenged by my own enactment of it. Learning to reframe these …


Genetic Relative-Finder Services: A Qualitative Study Of Consumer Experiences, Sarah A. Sciba Jan 2025

Genetic Relative-Finder Services: A Qualitative Study Of Consumer Experiences, Sarah A. Sciba

Theses and Dissertations

Background: Genetic genealogy is an emergent topic in sociology. To date, over 41 million individuals worldwide have tested with the top four direct-to-consumer genetic testing (DTCGT) companies: AncestryDNA, FamilyTreeDNA, 23andMe, and MyHeritageDNA (Glynn 2022). These tests provide consumers with ethnicity estimates, a list of DNA cousin matches, or both. Despite the popularity of DTCGT, there is a lack of data on consumer experiences with genetic relative-finder services (GRF) in the sociological literature. Methodology: I conducted exploratory, qualitative research in the form of in-depth interviews with eight adult women who have used GRF. I gathered data about their motivations for participation …


Theoretical Frameworks Used To Conceptualize The Intersection Of Deafness, Emotional/Behavioral Disabilities, And Language In The Literature: A Scoping Review, Jeremy M. Peterson Jan 2025

Theoretical Frameworks Used To Conceptualize The Intersection Of Deafness, Emotional/Behavioral Disabilities, And Language In The Literature: A Scoping Review, Jeremy M. Peterson

Theses and Dissertations

The prevalence rate for emotional/behavioral disabilities (EBD) among d/Deaf and hard of hearing (d/DHH) students has consistently been reported as statistically elevated in the literature, but the exact reason for this high prevalence has not been determined. Factors such as diagnostic shadowing, language proficiency, and difficulties in interfamilial communication have been identified; however, recent research suggests that language deprivation may also be a contributing factor. The intersection of language deprivation and EBD among d/DHH students has been studied by numerous researchers, but, to date, no one has explored how these topics are conceptualized together in the literature. As such, I …


A Qualitative Inquiry Into The (In)Visibility Of Black Women Leaders In Social Work, Jere Murry Jan 2025

A Qualitative Inquiry Into The (In)Visibility Of Black Women Leaders In Social Work, Jere Murry

Theses and Dissertations

Black women are vital contributors and innovators within the American workforce yet remain underrepresented in executive leadership roles in most employment settings. Despite the contributions Black women have made, our continued marginalization is a direct result of systemic oppression and institutionalized racism, which persistently deny Black women opportunities for leadership ascension (Beckwith et al., 2016; Collins, 2000; Crenshaw et al., 1995; Wilkerson, 2020). This qualitative narrative approach explores the stories of Black women leaders employed in the child welfare and foster care system, illuminating the challenges, including systemic barriers, limited mentorship, and inequitable career advancement practices. This study examines the …


Examining The Impact Of Conceptual Mathematics Instructional Practices On Middle School Achievement For Low-Income Public-School Students, Tracy L. Donath Jan 2025

Examining The Impact Of Conceptual Mathematics Instructional Practices On Middle School Achievement For Low-Income Public-School Students, Tracy L. Donath

Theses and Dissertations

This dissertation in practice investigates the persistent decline in mathematics proficiency between the fourth and fifth grades, particularly among low-income compared to high-income students in a large, urban public school district in central Illinois. Using Mintrop’s Cycle of Inquiry and the CPED framework in a 90-day intervention, seven fifth-grade teachers implemented small group lessons designed to build students’ conceptual understanding of grade level mathematics. This data-driven intervention encouraged the teachers to use a variety of manipulatives and visual representations to improve students’ mathematics proficiency on four grade level Common Core standards. Data collected through classroom pretests, posttests, and exit tickets, …


Navigating Intelligence: Exploring The Social Implications Of Smartness For Economically Disadvantaged Black Boys, Errika Tenise Baker Perkins Jan 2025

Navigating Intelligence: Exploring The Social Implications Of Smartness For Economically Disadvantaged Black Boys, Errika Tenise Baker Perkins

Theses and Dissertations

With a focus on how perceptions of race and socioeconomic class interact to influence friendships and peer acceptability, this study examined the social experiences of Black males with academic potential who come from low-income families. Using Critical Race Theory (CRT), Du Bois’ concept of double consciousness, and the framework of racial opportunity cost as guiding frameworks, the study examined how “smartness” functions as a cultural practice tethered to whiteness and how these dynamics affect identity and belonging.

This study was conducted using a qualitative research design, leveraging an interpretivist paradigm. To extract the stories of the research participants, semi-structured interviews …


The Impact Of Coaching On Teachers' Implementation Fidelity Of Goal Setting Strategy, Brandi M. Greene Jan 2025

The Impact Of Coaching On Teachers' Implementation Fidelity Of Goal Setting Strategy, Brandi M. Greene

Theses and Dissertations

Educational settings are filled with educators who have varying experiences in working with students who have disabilities and students who are considered at-risk. Typically, students who have disabilities or are considered at-risk struggle with self-regulation skills and require interventions to improve. However, literature has shown that there is very little training for teachers that will help them implement evidence-based strategies with fidelity. One of the strategies that can be used to improve self-regulation is goal setting, however, within the literature for the goal setting strategy, teachers are not well equipped to implement the strategy. Coaching has been deemed an effective …


The Comparison Of Human And Machine Performance In Object Recognition, Gokcek Kul Jan 2025

The Comparison Of Human And Machine Performance In Object Recognition, Gokcek Kul

School of Psychology Theses

Deep learning algorithms have advanced significantly due to better hardware and large training sets, with some claiming they now match or exceed human performance. Recent findings indicate improvements in robustness against Out-Of-Distribution benchmark sets and alignment with human categorisation behaviour. This thesis evaluates various machine learning models to ensure a fair comparison with human performance using principles from comparative psychology. Chapter 2 introduces a psychologically grounded framework for comparing human and machine object categorisation performance, focusing on different presentation times and task complexities. The results indicate that while recent machine learning models have reached or exceeded human performance under optimised …


Exploring The Mechanisms Of Functional Imagery Training For Sleep Problems: A Single Arm Pilot Study, Ross Allen, Jackie Andrade Jan 2025

Exploring The Mechanisms Of Functional Imagery Training For Sleep Problems: A Single Arm Pilot Study, Ross Allen, Jackie Andrade

School of Psychology Theses

Functional Imagery Training (FIT) is a brief motivational intervention grounded in the Elaborated Intrusion theory of desire. It helps individuals use personalised, emotionally vivid mental imagery to support goal pursuit by drawing on past successes to plan actions, overcome obstacles, and rehearse behavioural strategies. Delivered in the client-centred style of Motivational Interviewing (MI), FIT aims to strengthen motivation for sustained behaviour change. While FIT has shown promise in areas such as weight loss and anxiety, its application to sleep-related behaviour change remains unexplored. This single-arm pilot study examined whether FIT is associated with improvements in sleep quality and motivation to …


What Helps And Hinders Staff Supporting People With Intellectual Disabilities Regarding Sex And Relationships, Laurence Constable, Deanna Gallichan Jan 2025

What Helps And Hinders Staff Supporting People With Intellectual Disabilities Regarding Sex And Relationships, Laurence Constable, Deanna Gallichan

School of Psychology Theses

Background Studies have suggested that staff experience multiple obstacles to providing effective support around relationships and sexuality. The literature has suggested several potential solutions yet it is not clear what impedes the implementation of these. Understanding these barriers could improve care. Methods Two focus groups were carried out with a total of 13 participants recruited from the Southwest of England. Participants were recruited from client-facing roles across care providers, education provision, and social care provision. The focus groups were analysed using reflexive thematic analysis. Findings Four themes were drawn from the data. These were ‘Fear hinders care’, ‘Care is led …


Exploring Individuals’ Experiences Of Working With Probation Who Have Personality Disorder: A Community-Based Participatory Action Research Approach., Nikki Morfey Jan 2025

Exploring Individuals’ Experiences Of Working With Probation Who Have Personality Disorder: A Community-Based Participatory Action Research Approach., Nikki Morfey

School of Psychology Theses

Utilizing a Community-Based Participatory Action Research approach, semi-structured interviews were used to explore seven individuals’ experiences of working with Probation who self-identified as screening into the Offender Personality Disorder (OPD) Pathway. Interpretative Phenomenological Analysis (IPA) of the data resulted in the construction of six Group Experiential Themes. Findings reflect participant confusion with the Personality Disorder label in light of feeling it was imposed without discussion, speaking to their experiences of the power dynamic in the probation relationship. Participants described being reduced to a case to be managed, with no space to be seen as a person, and a gap between …


Masculinity, Muscles, And Minds. Investigating The Interplay Of Factors Affecting Gym-Attending Men For Psychological Formulation., Abigail Middlecote Jan 2025

Masculinity, Muscles, And Minds. Investigating The Interplay Of Factors Affecting Gym-Attending Men For Psychological Formulation., Abigail Middlecote

School of Psychology Theses

Background: This study explores pursuits of a muscular ideal among gym-attending men, to aid understanding and exploration of Drive for Muscularity, considering potential for a Compassion Focused Therapy formulation.Methods: Using a mixed-methods approach, the research examines psycho-social dynamics surrounding ideals and experiences of men, particularly the role of masculinity within a western society. Quantitative data from 80 men analysed relationships among Gender Role Conflict, Traditional Masculine Ideology, body image, Drive for Muscularity, social rank, Attachment, Self-Compassion, Body-Compassion, and Help-Seeking. Qualitative interviews with eight participants focused on relevance of the CFT-formulation in considering these dynamics.Results: Quantitative findings demonstrated most variables significantly …


The Experiences Of Systemic Invalidation In Chronic Pain Care Among Socioeconomically Disadvantaged Individuals: An Interpretative Phenomenological Study, Claira Moro Jan 2025

The Experiences Of Systemic Invalidation In Chronic Pain Care Among Socioeconomically Disadvantaged Individuals: An Interpretative Phenomenological Study, Claira Moro

School of Psychology Theses

This study explored the lived experiences of individuals from socioeconomically disadvantaged communities living with chronic pain and prescribed pain-relief medication. Using Interpretative Phenomenological Analysis, eight participants were recruited from a single primary care network in England. Two Group Experiential Themes were developed. This paper reports one: From dismissed to disengaged: the trauma of seeking help, with three sub-themes: (1) “Being fobbed off” – dismissal across healthcare and benefit systems; (2) “It just seemed horrible to me, to take it off me” – pain relief as withdrawn, stigmatised, or conditional; and (3) “Do I want to poke the bear?” – disengagement …


‘I Am Free, But I Am Not Free’: Nature-Based Interventions With Refugee And Asylum Seekers – An Ethnographic Action Informed Study, Louise Morgan Jan 2025

‘I Am Free, But I Am Not Free’: Nature-Based Interventions With Refugee And Asylum Seekers – An Ethnographic Action Informed Study, Louise Morgan

School of Psychology Theses

Refugees and asylum seekers (RAS) in the UK face significant barriers to well-being due to hostile immigration policies and limited mental health support. Nature-based interventions (NBIs) are emerging as culturally inclusive psychosocial support, yet RAS experiences remain underexplored. An Ethnographic Action Research (EAR) informed approach was used to examine a nature-based programme in Southwest England, developed with four lived experience co-researchers. Data was collected through five observation days, sixteen conversations, and one focus group, involving three staff facilitators and 30 RAS participants. Thematic Framework Analysis identified four themes: To Access, To Connect and Belong, To Survive, and To Be Me …


Bridging The Gap: A Mixed Methods Study Of Trainee Clinical Psychologists’ Experiences And Learning Needs For Working With Refugees, With Co-Produced Training Guidelines., Megan Stuart-Richards Jan 2025

Bridging The Gap: A Mixed Methods Study Of Trainee Clinical Psychologists’ Experiences And Learning Needs For Working With Refugees, With Co-Produced Training Guidelines., Megan Stuart-Richards

School of Psychology Theses

AbstractRefugees face unique and traumatising challenges to their mental health across multiple socio-political climates. Services are providing inequitable support for refugees, which lack appreciation of transcultural conceptualisations of mental distress, amongst a backdrop of social injustice. Refugees were employed as Co-researchers to co-produce every stage of this project. Reflexive Thematic Analysis was utilised in this study to examine experiences and learning needs of 79 Trainee Clinical Psychologists (TCP’s) in their survey responses. Novel training guidelines, to be accessed via ‘supplementary materials’, were co-produced alongside scoped learning needs, which contribute to health research and practice. Four interrelated overarching themes became evident. …


A Community-Based Participatory Action Research Project Exploring The Experiences Of Suicidal Distress For Autistic Adults: An Interpretive Phenomenological Study, Kyah Sisulu, Emily Hustwick, Philippa Wood, Bethany George, Lealah Hewitt-Johns Jan 2025

A Community-Based Participatory Action Research Project Exploring The Experiences Of Suicidal Distress For Autistic Adults: An Interpretive Phenomenological Study, Kyah Sisulu, Emily Hustwick, Philippa Wood, Bethany George, Lealah Hewitt-Johns

School of Psychology Theses

Background: Suicide is the leading cause of death for young people aged 15–29 (WHO, 2021). Autistic individuals experience elevated rates of mental health difficulties, often linked to stigma, discrimination, and a lack of appropriate support (Botha & Frost, 2020; Hedley et al., 2018). They are significantly more likely to experience suicidal thoughts and behaviours than the general population (Hirvikoski et al., 2016). Despite this, limited research has explored autistic adults’ lived experiences of suicidal distress. Calls from autistic advocates highlight the need for inclusive, co-produced research to avoid perpetuating harm (Pellicano et al., 2014; Kapp et al., 2013).Aims: This study …


Bcg-Induced Dna Methylation Changes Improve Coronavirus Disease 2019 Vaccine Immunity Without Decreasing The Risk For Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Marisa Lozano, Seth P Lerner, Rebecca Hannigan, Tomoki Nishiguchi, Abhimanyu, Daanish Sheikh, Malik Ladki, Alexandra Portillo, Amrit Koirala, Tajhal D Patel, Zoe Spieler, Aaron B Benjamin, Maxim Lebedev, Theresa U Ofili, Robert W Hutchison, George Udeani, Lynne A Opperman, Gabriel Neal, Anna M Mandalakas, Mihai G Netea, Moshe Arditi, Pablo Avalos, Sandra L Grimm, Cristian Coarfa, Jeffrey D Cirillo, Andrew R Dinardo Jan 2025

Bcg-Induced Dna Methylation Changes Improve Coronavirus Disease 2019 Vaccine Immunity Without Decreasing The Risk For Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Marisa Lozano, Seth P Lerner, Rebecca Hannigan, Tomoki Nishiguchi, Abhimanyu, Daanish Sheikh, Malik Ladki, Alexandra Portillo, Amrit Koirala, Tajhal D Patel, Zoe Spieler, Aaron B Benjamin, Maxim Lebedev, Theresa U Ofili, Robert W Hutchison, George Udeani, Lynne A Opperman, Gabriel Neal, Anna M Mandalakas, Mihai G Netea, Moshe Arditi, Pablo Avalos, Sandra L Grimm, Cristian Coarfa, Jeffrey D Cirillo, Andrew R Dinardo

Faculty, Staff and Students Publications

BACKGROUND: The BCG vaccine induces trained immunity, an epigenetic-mediated increase in innate immune responsiveness. Therefore, this clinical trial evaluated if BCG-induced trained immunity could decrease coronavirus disease 2019 (COVID-19)-related frequency or severity.

METHODS: A double-blind, placebo-controlled clinical trial of healthcare workers randomized participants to vaccination with BCG TICE or placebo (saline). Enrollment included 529 healthcare workers randomized to receive BCG or placebo. Primary analysis evaluated COVID-19 disease frequency, while secondary analysis evaluated coronavirus immunity in a subset of participants. Study enrollment ceased early in December 2020 following introduction of COVID-19-specific vaccines.

RESULTS: Study enrollment was halted early, prior to reaching …


Proteomic Characterization And Comparison Of The Infective And Adult Life Stage Secretomes From Necator Americanus And Ancylostoma Ceylanicum, Mali Camberis, Graham Legros, Bin Zhan, Maria Elena Bottazzi, Ricardo T Fujiwara, Edita Ritmejeryte, Thewarach Laha, Sujittra Chaiyadet, Piyanan Taweethavonsawat, Paul J Brindley, Bethany K Bracken, Paul R Giacomin, Makedonka Mitreva, Alex Loukas Jan 2025

Proteomic Characterization And Comparison Of The Infective And Adult Life Stage Secretomes From Necator Americanus And Ancylostoma Ceylanicum, Mali Camberis, Graham Legros, Bin Zhan, Maria Elena Bottazzi, Ricardo T Fujiwara, Edita Ritmejeryte, Thewarach Laha, Sujittra Chaiyadet, Piyanan Taweethavonsawat, Paul J Brindley, Bethany K Bracken, Paul R Giacomin, Makedonka Mitreva, Alex Loukas

Faculty, Staff and Students Publications

More than 470 million people globally are infected with the hookworms Ancylostoma ceylanicum and Necator americanus, resulting in an annual loss of 2.1 to 4 million disability-adjusted-life-years. Current infection management approaches are limited by modest drug efficacy, the costs associated with frequent mass drug administration campaigns, and the risk of reinfection and burgeoning drug resistance. Subunit vaccines based on proteins excreted and secreted (ES) by hookworms that reduce worm numbers and associated disease burden are a promising management strategy to overcome these limitations. However, studies on the ES proteomes of hookworms have mainly described proteins from the adult life stage …


From Myriad To Moderna: The Modern (Bio)Pharmaceutical Company, Ana Santos Rutschman Jan 2025

From Myriad To Moderna: The Modern (Bio)Pharmaceutical Company, Ana Santos Rutschman

Faculty Publications

This Article examines the emergence of two modern pharmaceutical companies: Myriad and Moderna. After providing a brief background on each company, this Article contrasts them across the following areas: the technologies they have brought to market; their location; their start-up stages and the role that venture capital played in catalyzing their evolution from start-ups to large corporate structures; their relationships with other entities in the private sector, in academia and in the public sector; and their intellectual property and licensing strategies.


The Military's Constitutional Role, Brenner M. Fissell Jan 2025

The Military's Constitutional Role, Brenner M. Fissell

Faculty Publications

A basic principle of the American constitutional order is that civilian authority must be supreme over that of the military. The violation of this principle by the British was one of the grievances enumerated in the Declaration of Independence, and the Framers responded with a Constitution that made military rule impossible. But why is so-called “civilian control” of the military so important? This deep normative question has yet to be thoroughly answered by scholars, most of who assume it away as a given. This Article takes up that task, using contemporary political theory to defend the principle of civilian control. …