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Articles 276361 - 276390 of 5210908
Full-Text Articles in Entire DC Network
The Good Guys, Veronica Ordaz
The Good Guys, Veronica Ordaz
Mighty Pen Project Anthology & Archive
A routine patrol around the Tallil air force base takes a sharp turn when our narrator is confronted by a grieving mother, screaming in a language she cannot understand.
Despair transcends language, and guilt sticks around like desert gnats on tape.
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and …
What's It Like, Jon Merrill
What's It Like, Jon Merrill
Mighty Pen Project Anthology & Archive
What’s it like
Not training to kill another human being at 18
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience so both writer and audience may benefit.
Sarge, Jon F. Merrill
Sarge, Jon F. Merrill
Mighty Pen Project Anthology & Archive
A short story on how a service dog can change a man's life.
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience so both writer and audience may benefit.
Tunnel Rat - Part 2, Gene Pearson
Tunnel Rat - Part 2, Gene Pearson
Mighty Pen Project Anthology & Archive
Our combat medic has a much needed conversation with the tunnel rat on whether intervention is needed; an understanding is reached.
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience so both writer and audience may benefit.
God Of Baghdad, Phillip Trezza
God Of Baghdad, Phillip Trezza
Mighty Pen Project Anthology & Archive
In a powerful one-act play, a young Army medic rushes to a crowded Baghdad street corner destroyed by an IED hidden in a truck. The human carnage is everywhere; he must choose who will live and who will die. In those moments, in that place, he must be the God of Baghdad.
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized …
Medals, Gene Pearson
Medals, Gene Pearson
Mighty Pen Project Anthology & Archive
A young field medic in Vietnam tries his hardest save his men among the chaos of war.
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience so both writer and audience may benefit.
Wian, Ralph Andersen
Wian, Ralph Andersen
Mighty Pen Project Anthology & Archive
“Am I named after someone? A relative? A friend of my father? A friend of yours? Or did you just pick it out of a hat?”
Names, like everything else, are made of stories. A boy, on the cusp of adulthood, asks his mother what his is.
Journal 2, Ryan Peschman
Journal 2, Ryan Peschman
Mighty Pen Project Anthology & Archive
A stunningly kaleidoscopic narrative that asks, over and over, what it means to be alive.
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience so both writer and audience may benefit. CONTENT WARNINGS: Animal death, Autopsy related gore, Child …
Wednesday In The Desert, Sabrina Fredrick
Wednesday In The Desert, Sabrina Fredrick
Mighty Pen Project Anthology & Archive
A young woman wakes up one beautiful morning, and realizes she has the power to change her own life.
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience so both writer and audience may benefit.
To Honor Their Courage And Commitment, Laura Bender
To Honor Their Courage And Commitment, Laura Bender
Mighty Pen Project Anthology & Archive
Two veterans from different eras keep memories alive through archival work.
"So many of the pictures were fading, curling, and cracking. Add a few years, and the history captured in light and shadow will be lost, like so many veterans and the stories they never told.
I commit mine to paper so they won’t be forgotten."
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their …
Damaged Goods, Jesse Huckins
Damaged Goods, Jesse Huckins
Mighty Pen Project Anthology & Archive
"I’m ready to go back now // to a place that’s far away-"
Short poem about home, and returning to it.
Twenty Years Later, John Price
Twenty Years Later, John Price
Mighty Pen Project Anthology & Archive
Twenty years after the death of his son, a grieving father has a chance to meet the soldiers his son had lead in combat. This story serves as a recollection of those few days, and what it means to be loved into the future.
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program …
Tim's Dedication, John Henry Price Iii
Tim's Dedication, John Henry Price Iii
Mighty Pen Project Anthology & Archive
My son Tim attended VA Tech as a member of the Corps of Cadets. He graduated and was commissioned as second lieutenant in 2002. Attended Military Police Officers Basic course at FT Leonard Wood, MO. Reported to permanent duty station in Giessen, GA. Served as a platoon leader with 527th MP Company in Baghdad, Iraq during OIF 1. Three months after redeploying to Germany, volunteered to return to Baghdad to replace poor leader with 127th MP Company during OIF 2. KIA, Baghdad, Iraq 7SEP04, shot by a sniper.
Articles, stories, and other compositions in this archive were written by participants …
You're In The Army Now, John Henry Price Iii
You're In The Army Now, John Henry Price Iii
Mighty Pen Project Anthology & Archive
An Army recruit plots to exact revenge on a bully Corporal everyone despises. How will he do it? Will he get away with it?
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience so both writer and audience may …
Extra Bucks, Joseph Stanley Maslanka
Extra Bucks, Joseph Stanley Maslanka
Mighty Pen Project Anthology & Archive
A young married man, fresh out of the Marine Corps, has to decide whether it's worth joining the Army Reserves just for a few extra bucks every month. For a Marine, that's a heavy lift.
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories …
A Medal For My Cat, Margaret Serig
A Medal For My Cat, Margaret Serig
Mighty Pen Project Anthology & Archive
“A Medal for My Cat” chronicles the support and sacrifice that family provide to service members, as seen through the eyes of a cat. CiCi graduates from a PetSmart adoption program only to find herself enlisted as a lifelong wingman. She takes on her new role with gusto, usually leading the way, but sometimes… needing to stop and lick her wounds.
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, …
Inshallah, Phillip Trezza
Inshallah, Phillip Trezza
Mighty Pen Project Anthology & Archive
Set during a deployment in Iraq, Inshallah follows a U.S. Army medic reflecting on the chaos, camaraderie, and moral ambiguity of war. As his platoon conducts a routine patrol, they encounter violence, uncertainty, and a wounded enemy combatant whose life hangs in the medic’s hands. Through moments of tension, dark humor, and introspection, the story explores the psychological toll of combat and the fragile line between duty and humanity. Ultimately, the medic chooses compassion over vengeance, leaving the outcome to fate—Inshallah, if God wills it.
Articles, stories, and other compositions in this archive were written by participants in …
Taken For A Ride, Reinetta Van
Taken For A Ride, Reinetta Van
Mighty Pen Project Anthology & Archive
The author recounts a moment of realization about her fiancé Frank’s drinking during a bike ride, which leads to a deeper conversation at home about alcohol’s impact on their relationship.
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience …
Con Thien - The Ambush, Richard Michael Everington
Con Thien - The Ambush, Richard Michael Everington
Mighty Pen Project Anthology & Archive
This true story takes place just below the DMZ of South Vietnam, during the undeclared war years of 1967- 1968, at Con Thien. The Marine forward combat base had sustained constant artillery bombardment and enemy attacks for a year. The Marine’s newly acquired night vision scopes discovered that North Vietnamese recon teams were coming in at night to spy on the base. An ambush was put together to eliminate the enemy reconnaissance team and to get revenge from loses from the week before. The plot revolves around Rick and Smitty, two of the lowest ranking Marines in the platoon.
Articles, …
Assessing The Potential For Bigleaf Maple Syrup Production In Humboldt County, Ca, David A. Reinhart, Juan A. Ramos-Cool, Liam H. Richardson
Assessing The Potential For Bigleaf Maple Syrup Production In Humboldt County, Ca, David A. Reinhart, Juan A. Ramos-Cool, Liam H. Richardson
Undergraduate Scholarship
The bigleaf maple (Acer macrophyllum, Pursh) is the largest maple of the Pacific Northwest. While it has generally been treated as a nuisance in timber harvesting operations, a small amount of research has been conducted on its sugaring ability in Oregon, Washington, and British Columbia. This research has yet to reach further south in the species' range. This study aims to help a California landowner understand which maple trees on his property produce the most maple sap, to gauge what environmental factors contribute to maple sap production, and to find greater implications for the production of maple sap …
The Horrors Of History: Gender, Folklore, And Puritanism In Robert Eggers’ The Witch, Trinity Stuckey
The Horrors Of History: Gender, Folklore, And Puritanism In Robert Eggers’ The Witch, Trinity Stuckey
Undergraduate Scholarship
This paper examines Robert Eggers' 2015 folk horror film The Witch as a legitimate form of historical interpretation that illuminates the intersection of gender, folklore, and religious belief in 1630s colonial New England. Through analysis of primary sources including Cotton Mather's Memorable Providences, Samuel Willard's possession accounts, and Salem witch trial records, this study demonstrates how Eggers' meticulous attention to historical detail creates a narrative that captures the psychological and sociocultural dimensions of Puritan experience. The paper argues that by taking seriously the theological worldview of its subjects rather than dismissing supernatural elements as superstition, The Witch achieves a …
Accelerated Aging System For Pinniped Tags, Sean Shermer, Nathan Vasquez, Deekshitha Garige
Accelerated Aging System For Pinniped Tags, Sean Shermer, Nathan Vasquez, Deekshitha Garige
Undergraduate Scholarship
This project focused on the design of an accelerated aging system intended to evaluate the durability of pinniped identification tags used in marine mammal research. The system was developed in collaboration with the Cal Poly Humboldt Marine Lab and NOAA, under the guidance of Dr. Dawn Goley, to address the limitations of field based durability testing, which is slow, inconsistent, and difficult to reproduce. The primary objective was to create a repeatable laboratory testing framework capable of simulating multiple environmental stressors experienced by pinniped tags. This includes the accelerated tests of UV radiation, mechanical abrasion, temperature cycling and biological fouling. …
Interaction Of Cardiac Leiomodin With The Native Cardiac Thin Filament, Madison Little, Cristina M. Risi, Tania M. Larrinaga, Mason D. Summers, Tyler Nguyen, Garry E. Smith Jr., Jennifer Atherton, Carol C. Gregorio, Alla S. Kostyukova, Vitold E. Galkin
Interaction Of Cardiac Leiomodin With The Native Cardiac Thin Filament, Madison Little, Cristina M. Risi, Tania M. Larrinaga, Mason D. Summers, Tyler Nguyen, Garry E. Smith Jr., Jennifer Atherton, Carol C. Gregorio, Alla S. Kostyukova, Vitold E. Galkin
Department of Biomedical and Translational Sciences Faculty Publications
Every heartbeat depends on cyclical contraction-relaxation produced by the interactions between myosin-containing thick and actin-based thin filaments (TFs) arranged into a crystalline-like lattice in the cardiac sarcomere. Therefore, the maintenance of thin filament length is crucial for myocardium function. The thin filament is comprised of an actin backbone, the regulatory troponin complex and tropomyosin that controls interactions between thick and thin filaments. Thin filament length is controlled by the tropomodulin family of proteins; tropomodulin caps pointed ends of thin filaments, and leiomodin (Lmod) promotes elongation of thin filaments by a “leaky-cap” mechanism. The broader distribution of Lmod on the thin …
Eeg Spectral Analysis Of Nighttime Sleep And Daytime Mslts And Neurocognitive Evaluations In Subjects With Co-Morbid Insomnia And Osa, Yuan Shi, Yuru Nie, Fengyi Hao, Xujun Feng, Ye Zhang, Larry D. Sanford, Rong Ren, Xiangdong Tang
Eeg Spectral Analysis Of Nighttime Sleep And Daytime Mslts And Neurocognitive Evaluations In Subjects With Co-Morbid Insomnia And Osa, Yuan Shi, Yuru Nie, Fengyi Hao, Xujun Feng, Ye Zhang, Larry D. Sanford, Rong Ren, Xiangdong Tang
Department of Biomedical and Translational Sciences Faculty Publications
Background
Chronic insomnia and obstructive sleep apnea commonly co-occur. Few studies have explored the neurophysiological and neurocognitive characteristics of COMISA, which could help guide improving treatment diagnostic tools and determining novel therapeutic targets. This study aims to explore the neurophysiological and neurocognitive characteristics of COMISA using electroencephalographic (EEG) spectral analysis and subjective and objective neurocognitive measurements.
Methods
Participants were from our community recruited OSA-insomnia-COMISA cohort with 206 included for our current analysis including 74 chronic insomniacs (CIs), 55 OSA patients and 77 COMISA patients. Standard polysomnography (PSG) and multiple sleep latency tests (MSLTs) were recorded and used to obtain relative …
Codon Composition In Human Oocyters Reveals Age-Associated Defects In Mrna Decay, Pavla Brachova, Lane K. Christenson, Nehemiah S. Alvarez
Codon Composition In Human Oocyters Reveals Age-Associated Defects In Mrna Decay, Pavla Brachova, Lane K. Christenson, Nehemiah S. Alvarez
Department of Biomedical and Translational Sciences Faculty Publications
Oocytes from women of advanced reproductive age exhibit diminished developmental potential, but the underlying mechanisms remain incompletely defined. Oocyte maturation depends on translational control of maternal mRNA synthesized during growth. We performed a computational analysis on human oocytes from women < 30 versus ≥40 years and observed that mRNA GC content correlates negatively with half-life in oocytes from young (< 30 yr) but positively with oocytes from aged (>40 yr) women. In young oocytes, longer mRNA half-life is associated with lower protein abundance, whereas in aged oocytes GC content correlates positively with protein abundance. During the GV-to-MII transition, codon composition stratifies stability: codons that support rapid translation (optimal) stabilize mRNA, while slow-translating codons (non-optimal) promote decay. With reproductive aging, GC-containing codons become more optimal and align with increased …
Antibiotic Resistance: The Growing Threats And Potential Solutions, Olisaemeka Zikora Akunne, Blessing Nkechi Emmanuel, Umar Faruk Saidu, Ayobami Sunday Akinnawo, Nasiru Ademola Adeyemi, Livia Chinaza Egoh, Malami Aishatu Muhammad, Olusegun Ayo Ade-Adekunle, Deborah Ahuoyiza Peter, Anne Amina Freitas
Antibiotic Resistance: The Growing Threats And Potential Solutions, Olisaemeka Zikora Akunne, Blessing Nkechi Emmanuel, Umar Faruk Saidu, Ayobami Sunday Akinnawo, Nasiru Ademola Adeyemi, Livia Chinaza Egoh, Malami Aishatu Muhammad, Olusegun Ayo Ade-Adekunle, Deborah Ahuoyiza Peter, Anne Amina Freitas
Department of Biomedical and Translational Sciences Faculty Publications
Antibiotic resistance (AR) has become a critical global health crisis, threatening the efficacy of antibiotics and increasing healthcare costs, morbidity, and mortality. The One Health approach, which emphasizes the interconnectedness of human, animal, and environmental health, is increasingly recognized as an essential framework for addressing the complex drivers of AR. This review explores the mechanisms of resistance, such as genetic mutations, horizontal gene transfer, and biofilm formation, along with contributing factors such as the overuse of antibiotics in healthcare and agriculture. We assess both traditional and emerging strategies to combat AR, including antimicrobial stewardship, the development of new antibiotics, and …
Reduced Slow Wave Sleep Is Associated With Increased Risk Of Short Stature In Children: A Cross-Sectional Study, Zhaohua Chen, Yuan Shi, Fei Lei, Xujun Feng, Lu Tan, Taomei Li, Junying Zhou, Yuanfeng Sun, Jiamin Liao, Yun Li, Zhoulong Yu, Jian Jiao, Yanyan Wang, Larry D. Sanford, Michael V. Vitiello, Ye Zhang, Rong Ren, Xiangdong Tang
Reduced Slow Wave Sleep Is Associated With Increased Risk Of Short Stature In Children: A Cross-Sectional Study, Zhaohua Chen, Yuan Shi, Fei Lei, Xujun Feng, Lu Tan, Taomei Li, Junying Zhou, Yuanfeng Sun, Jiamin Liao, Yun Li, Zhoulong Yu, Jian Jiao, Yanyan Wang, Larry D. Sanford, Michael V. Vitiello, Ye Zhang, Rong Ren, Xiangdong Tang
Department of Biomedical and Translational Sciences Faculty Publications
Objective: Although growth hormone was shown to be specifically released during slow wave sleep (SWS), no population-based evidence has demonstrated the association between sleep quality and childhood height. To address this gap, our study aims to investigate the relationship between SWS and height of children.
Methods: We analyzed polysomnography data and z-scores for height in 2527 suspected obstructive sleep apnea (OSA) children (537 non-OSA children and 1990 OSA children) collected over the past 16 years. Different grades of z-scores for height and SWS were classified by the quartile method, and the lowest z-scores for height quartile defined short stature as …
Swinging Lever Mechanism Of Myosin Directly Shown By Time-Resolved Cryo-Em, David P. Klebl, Sean N. Mcmillan, Cristina Risi, Eva Forgacs, Betty Virok, Jennifer L. Atherton, Sarah A. Harris, Michele Stofella, Donald A. Winkelmann, Frank Sobott, Vitold E. Galkin, Peter J. Knight, Stephen P. Muench, Charlotte A. Scarfi, Howard D. White
Swinging Lever Mechanism Of Myosin Directly Shown By Time-Resolved Cryo-Em, David P. Klebl, Sean N. Mcmillan, Cristina Risi, Eva Forgacs, Betty Virok, Jennifer L. Atherton, Sarah A. Harris, Michele Stofella, Donald A. Winkelmann, Frank Sobott, Vitold E. Galkin, Peter J. Knight, Stephen P. Muench, Charlotte A. Scarfi, Howard D. White
Department of Biomedical and Translational Sciences Faculty Publications
Myosins produce force and movement in cells through interactions with F-actin1. Generation of movement is thought to arise through actin-catalysed conversion of myosin from an ATP-generated primed (pre-powerstroke) state to a post-powerstroke state, accompanied by myosin lever swing2,3. However, the initial, primed actomyosin state has never been observed, and the mechanism by which actin catalyses myosin ATPase activity is unclear. Here, to address these issues, we performed time-resolved cryogenic electron microscopy (cryo-EM)4 of a myosin-5 mutant having slow hydrolysis product release5,6. Primed actomyosin was predominantly captured 10 ms after …
In Danger: Hiv Vaccine Research And Development In Europe, Roger Tatoud, Yves Lévy, Roger Le Grand, Jose Alcami, Giorgio Barbareschi, Christian Brander, Andrea Cara, Behazine Combadière, François Dabis, Sarah Fidler, Tomáš Hanke, Carolina Herrera, Gunilla B. Karlsson Hedestam, Hester Kuipers, Sheena Mccormack, Christiane Moog, Giuseppe Pantaleo, Laura Richert, Rogier W. Sanders, Robin Shattock, Hendrik Streeck, Rodolphe Thiebaut, Alexandra Trkola, Klaus Üeberla, Marit J. Van Gills, Ralf Wagner, Winfried Weissenhorn, Yazdan Yazdanpanah, Gabriella Scarlatti, Jean Daniel Lelièvre
In Danger: Hiv Vaccine Research And Development In Europe, Roger Tatoud, Yves Lévy, Roger Le Grand, Jose Alcami, Giorgio Barbareschi, Christian Brander, Andrea Cara, Behazine Combadière, François Dabis, Sarah Fidler, Tomáš Hanke, Carolina Herrera, Gunilla B. Karlsson Hedestam, Hester Kuipers, Sheena Mccormack, Christiane Moog, Giuseppe Pantaleo, Laura Richert, Rogier W. Sanders, Robin Shattock, Hendrik Streeck, Rodolphe Thiebaut, Alexandra Trkola, Klaus Üeberla, Marit J. Van Gills, Ralf Wagner, Winfried Weissenhorn, Yazdan Yazdanpanah, Gabriella Scarlatti, Jean Daniel Lelièvre
Department of Obstetrics & Gynecology Faculty Publications
Highly effective antiretroviral-based HIV prevention plays an important role in ending the global HIV/AIDS epidemic. However, the sustainable control of the epidemic is hampered by unequal access to prevention options, including HIV testing, alongside with drug resistance and ongoing barriers to accessing sustainable HIV treatment. Therefore, an HIV vaccine, combined with effective prevention and treatment, remains an absolute necessity to control the epidemic. Yet, the recent discontinuation of four major vaccine efficacy studies is raising concerns about the future of HIV vaccine research and development globally, and particularly in the European region where funding for vaccine research and development has …
Microbial Remodeling Of Gut Tryptophan Metabolism And Indole-3-Lactate Production Regulate Epithelial Barrier Repair And Viral Suppression In Human And Simian Immunodeficiency Virus Infections, Clarissa Santos Rocha, Katie L. Alexander, Carolina Herrera, Mariana G. Weber, Irina Grishina, Lauren A. Hirao, Dylan J. Kramer, Juan Arredondo, Abigail Mende, Katti R. Crakes, Anne N. Fenton, Maria L. Marco, David A. Mills, John C. Kappes, Lesley E. Smythies, Paul Ziprin, Sumathi Sankaran-Walters, Phillip D. Smith, Satya Dandekar
Microbial Remodeling Of Gut Tryptophan Metabolism And Indole-3-Lactate Production Regulate Epithelial Barrier Repair And Viral Suppression In Human And Simian Immunodeficiency Virus Infections, Clarissa Santos Rocha, Katie L. Alexander, Carolina Herrera, Mariana G. Weber, Irina Grishina, Lauren A. Hirao, Dylan J. Kramer, Juan Arredondo, Abigail Mende, Katti R. Crakes, Anne N. Fenton, Maria L. Marco, David A. Mills, John C. Kappes, Lesley E. Smythies, Paul Ziprin, Sumathi Sankaran-Walters, Phillip D. Smith, Satya Dandekar
Department of Obstetrics & Gynecology Faculty Publications
Gut inflammatory diseases cause microbial dysbiosis. Human immunodeficiency virus-1 (HIV) infection disrupts intestinal integrity, subverts repair/renewal pathways, impairs mucosal immunity and propels microbial dysbiosis. However, microbial metabolic mechanisms driving repair mechanisms in virally inflamed gut are not well understood. We investigated the capability and mechanisms of gut microbes to restore epithelial barriers and mucosal immunity in virally inflamed gut by using a multipronged approach: an in vivo simian immunodeficiency virus (SIV)-infected nonhuman primate model of HIV/AIDS, ex vivo HIV-exposed human colorectal explants and primary human intestinal epithelial cells. SIV infection reprogrammed tryptophan (TRP) metabolism, increasing kynurenine catabolite levels that are …